An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver and secreted into blood circulation. Angiotensinogen is the inactive precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 126.96.36.199.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Animals, Genetically Modified
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Receptor, Angiotensin, Type 1
Promoter Regions, Genetic
Gene Expression Regulation
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Genetic Predisposition to Disease
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Polymorphism, Single Nucleotide
"Interleukin-6 Mediates Angiotensinogen Gene Expression during Liver Regeneration". PLOS ONE. 8 (7): e67868. Bibcode:2013PLoSO ... Ashburner, M (2000). "Gene ontology: tool for the unification of biology. The Gene Ontology Consortium". Nat. Genet. 25 (1): 25 ... With DNA microarrays and genome-wide gene engineering, it is possible to screen global gene expression profiles to contribute a ... can be used to analyze the roles of genes in metabolic pathways and show the biological relationships between genes or gene- ...
Pathophysiology of hypertension
February 1999). "Angiotensinogen gene polymorphisms M235T/T174M: no excess transmission to hypertensive Chinese". Hypertension ... Single gene mutations can cause Mendelian forms of high blood pressure; ten genes have been identified which cause these ... Corvol P, Persu A, Gimenez-Roqueplo AP, Jeunemaitre X (June 1999). "Seven lessons from two candidate genes in human essential ... October 2000). "Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal ...
2005). "Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene". Int. J. Mol. Med. 13 ... "Entrez Gene: RREB1 ras responsive element binding protein 1". Bonomo, J. A.; Guan, M; Ng, M. C.; Palmer, N. D.; Hicks, P. J.; ... 2003). "p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription ... Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene. Mutations in RREB1 are ...
One of these genes is the angiotensinogen (AGT) gene, studied extensively by Kim et al. They showed that increasing the number ... It is also known that hypertension is highly heritable and polygenic (caused by more than one gene) and a few candidate genes ... More than 50 genes have been examined in association studies with hypertension, and the number is constantly growing. ... Another view is that hypertension can be caused by mutations in single genes, inherited on a Mendelian basis. Hypertension can ...
Sethi AA, Nordestgaard BG, Tybjaerg-Hansen A (July 2003). "Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk ... Gene knockouts, particularly in mice, are used experimentally to determine the normal functions of serpins by the effect of ... In animal models, gene targeting in induced pluripotent stem cells has been successfully used to correct an antitrypsin ... Predicted serpin genes are sporadically distributed in prokaryotes. In vitro studies on some of these molecules have revealed ...
"Effect of Renin-Angiotensin System Blockade on the Expression of the Angiotensinogen Gene and Induction of Hypertrophy in Rat ... "Effect of renin-angiotensin system blockade on the expression of the angiotensinogen gene and induction of hypertrophy in rat ... "RAS blockade decreases blood pressure and proteinuria in transgenic mice over-expressing rat angiotensinogen gene in the kidney ... "Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells". ...
ATP6AP2 human gene location in the UCSC Genome Browser. ATP6AP2 human gene details in the UCSC Genome Browser. v t e. ... Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I. This protein is associated with ... "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2". Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller ... 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. ...
... participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical ... The expression of various genes in the subfornical organ have been studied. For example, it was seen that water deprivation in ...
Renin stability regulatory element (REN-SRE)
Renin is secreted by renal juxtaglomerular cells and catalyses the conversion of angiotensinogen into angiotensin I which is ... gene. It acts to regulate the levels of renin protein produced in the cell. ...
Major basic protein
1990). "Cloning and sequence analysis of the human gene encoding eosinophil major basic protein". Gene. 86 (2): 285-289. doi: ... 1995). "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic ... is encoded in humans by the PRG2 gene. The protein encoded by this gene is the predominant constituent of the crystalline core ... "Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)". PDB: ...
The gene for renin, REN, spans 12 kb of DNA and contains 8 introns. It produces several mRNA that encode different REN isoforms ... The renin enzyme circulates in the bloodstream and hydrolyzes (breaks down) angiotensinogen secreted from the liver into the ... Mutations in the REN gene can be inherited, and are a cause of a rare inherited kidney disease, so far found to be present in ... Patients with a mutation in this gene can have a variable rate of loss of kidney function, with some individuals going on ...
... ogenEdit. Angiotensinogen (AGT) is an α-2-globulin produced constitutively and released into the circulation mainly ... Gene ontology. Molecular function. • type 1 angiotensin receptor binding. • hormone activity. • superoxide-generating NADPH ... Human angiotensinogen is 453 amino acids long, but other species have angiotensinogen of varying sizes. The first 12 amino ... negative regulation of gene expression. • regulation of renal output by angiotensin. • negative regulation of endopeptidase ...
DEHP has also been shown, in vitro using cardiac muscle cells, to cause activation of PPAR-alpha gene, which is a key regulator ... Also, DEHP caused down regulation of several growth factors, such as angiotensinogen, transforming growth factor-beta, vascular ... The decrease in expression and instability of connexin-43 may be due to the down regulation of tubulin and kinesin genes, and ... Posnack, Nikki Gillum; Lee, Norman H.; Brown, Ronald; Sarvazyan, Narine (2011). "Gene expression profiling of DEHP-treated ...
The OPN gene is composed of 7 exons, 6 of which containing coding sequence. The first two exons contain the 5' untranslated ... Ricardo SD, Franzoni DF, Roesener CD, Crisman JM, Diamond JR (May 2000). "Angiotensinogen and AT(1) antisense inhibition of ... PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) is one such enzyme, which extensively ... An OPN gene knock-out results in attachment instability at the maternal-fetal interface. GRCh38: Ensembl release 89: ...
... is an enzyme of the aminopeptidase group that in humans is encoded by the LNPEP gene. This gene encodes a zinc-dependent ... The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for ... Mutations in this gene have been associated to psoriasis risk.(doi:10.1038/jid.2013.317) Cystinyl aminopeptidase has been shown ... "Entrez Gene: LNPEP leucyl/cystinyl aminopeptidase". Sbodio, Juan I; Chi Nai-Wen (August 2002). "Identification of a tankyrase- ...
Renal tissue kallikrein
Elmoujahed A, Gutman N, Brillard M, Gauthier F (June 1990). "Substrate specificity of two kallikrein family gene products ... "Kinetic studies of rat renin and tonin on purified rat angiotensinogen". Canadian Journal of Biochemistry and Cell Biology. 62 ... Evans BA, Drinkwater CC, Richards RI (June 1987). "Mouse glandular kallikrein genes. Structure and partial sequence analysis of ... "Organization and expression of the rat kallikrein gene family". The Journal of Biological Chemistry. 264 (13): 7653-62. PMID ...
Role of angiotensinogen. Cell 71 : 169-180, 1992. Rousseau A., Michaud A., Chauvet M-T., Lenfant M. and Corvol P. The ... An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme ... Role of angiotensinogen". Cell. 71 (1): 169-80. doi:10.1016/0092-8674(92)90275-H. PMID 1394429. Dive, V.; Cotton, J.; Yiotakis ...
Pregnancy-associated plasma protein A
"Entrez Gene: PAPPA pregnancy-associated plasma protein A, pappalysin 1". Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen ... June 1995). "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major ... Pappalysin-1, also known as pregnancy-associated plasma protein A, is a protein encoded by the PAPPA gene in humans. PAPPA is a ... This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). PAPPA's ...
Tyrosine kinase 2
"Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277-82. PMID 2156206. "Entrez Gene ... a cytokine responsible for induction of angiotensinogen synthesis in liver through JAK/STAT3 pathway, which gets activated ... This gene encodes a member of the tyrosine kinase and, to be more specific, the Janus kinases (JAKs) protein families. This ... Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. Tyk2 was the first member of ...
List of MeSH codes (D12.644)
... interferon-stimulated gene factor 3 MeSH D12.644.360.024.301.500 - interferon-stimulated gene factor 3, alpha subunit MeSH ... angiotensinogen MeSH D12.644.456.120 - antipain MeSH D12.644.456.193 - bradykinin MeSH D12.644.456.193.400 - kallidin MeSH ... interferon-stimulated gene factor 3, gamma subunit MeSH D12.644.360.024.305 - pii nitrogen regulatory proteins MeSH D12.644. ... interferon-stimulated gene factor 3, gamma subunit MeSH D12.644.360.024.303 - interferon regulatory factors MeSH D12.644. ...
Angiotensin II receptor
Genes on human chromosome 3. *Genes on human chromosome X. *G protein-coupled receptors ... Propeptides: Angiotensinogen. *Angiotensin I. Combinations:. *Valsartan/hydrochlorothiazide. *Valsartan/hydrochlorothiazide/ ...
Majör bazik protein - Vikipedi
1990). "Cloning and sequence analysis of the human gene encoding eosinophil major basic protein". Gene. 86 (2). ss. 285-289. ... 1995). "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic ... "Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)". 2 Kasım ...
Sitokrom c bahasa Indonesia, ensiklopedia bebas
"Entrez Gene. Diakses tanggal 2010-11-14. *^ (Inggris) "Demonstration of Short-lived Complexes of Cytochrome c with Cytochrome ... Angiotensinogen " Caspase " F12 " Kimotiypsinogen " Pepsinogen " Proelastase " Prokarboksipolipeptidase " Prolipase " ...
Plasminogen activator inhibitor-2
Ye RD, Ahern SM, Le Beau MM, Lebo RV, Sadler JE (April 1989). "Structure of the gene for human plasminogen activator inhibitor- ... Ye RD, Ahern SM, Le Beau MM, Lebo RV, Sadler JE (April 1989). "Structure of the gene for human plasminogen activator inhibitor- ... gene are associated with basal and tumor necrosis factor-alpha-induced transcription in monocytes". European Journal of ... Isolation and characterization of the promoter region of the gene". Biochemical and Biophysical Research Communications. 156 (1 ...
Renin converts angiotensinogen (inactive form) to angiotensin I (active form). Angiotensin I flows in the bloodstream until it ... Braunwald, Eugene; Bonow, Robert O. (2012). Braunwald's heart disease : a textbook of cardiovascular medicine (9th ed.). ...
Pharmacodynamics of estradiol
Some prominent examples ERE-containing and hence estrogen-modulated genes in humans include the genes encoding the proteins ... and angiotensinogen). The greater hepatotropic potency of these estrogens relative to estradiol is related to susceptibility to ... angiotensinogen (AGT), pregnancy zone protein (PZP), coagulation factors, and numerous other hepatic proteins. Conversely, ... "Development of an androgen reporter gene assay (AR-LUX) utilizing a human cell line with an endogenously regulated androgen ...
Metaloproteinase matriks-2 bahasa Indonesia, ensiklopedia bebas
Angiotensinogen · Caspase · F12 · Kimotripsinogen · Pepsinogen · Proelastase · Prokarboksipolipeptidase · Prolipase · ... "Entrez Gene. Diakses tanggal 2010-12-06.. *^ (Inggris). "EC 188.8.131.52". Queen Mary University of London. Diakses tanggal 2010- ...
At the cellular level, receptors include nuclear receptors that bring about changes in gene expression through up-regulation or ... from a plasma α-2-globulin called angiotensinogen. This decapeptide is known as angiotensin I. It has no known biological ... homeostasis is carried out by several mechanisms including transcriptional regulation that can alter the activity of genes in ...
Over 400 genes are more specifically expressed in the liver, with some 150 genes highly specific for liver tissue. A large ... The liver synthesizes angiotensinogen, a hormone that is responsible for raising the blood pressure when activated by renin, an ... The remainder of the units (II to VIII) are numbered in a clockwise fashion: About 20,000 protein coding genes are expressed in ... with position along the portocentrovenular axis within a liver lobule dictating expression of metabolic genes involved in drug ...
Renin activates a circulating liver derived prohormone angiotensinogen by proteolytic cleavage of all but its first ten amino ... Inhibitor-Induced Cough and ACE Gene Polymorphism, Plasma Bradykinin, Substance P and ACE Inhibitor Concentration in Japanese ...
Gene regulation. Main article: Regulation of gene expression. At the cellular level, homeostasis is carried out by ... α-2-globulin called angiotensinogen. This decapeptide is known as angiotensin I. It has no known biological activity. ... At the cellular level, receptors include nuclear receptors that bring about changes in gene expression through up-regulation or ... several mechanisms including transcriptional regulation that can alter the activity of genes in response to changes. ...
Braunwald, Eugene, 1929-, Bonow, Robert O. (9th ed.). Philadelphia: Saunders. 2012. ISBN 9781437703986. . OCLC 671465395.. CS1 ... Renin converts angiotensinogen (inactive form) to angiotensin I (active form).. *Angiotensin I flows in the bloodstream until ...
Renin activates a circulating liver derived prohormone angiotensinogen by proteolytic cleavage of all but its first ten amino ... "No Relation between Angiotensin-Converting Enzyme (ACE) Inhibitor-Induced Cough and ACE Gene Polymorphism, Plasma Bradykinin, ...
Hati bahasa Indonesia, ensiklopedia bebas
"The Goldyne Savad Institute for Gene Therapy, Hadassah Hebrew University Hospital,; Galun E, Axelrod JH. Diakses tanggal 2010- ... angiotensinogen, sebuah hormon yang berperan untuk meningkatkan tekanan darah ketika diaktivasi oleh renin, sebuah enzim yang ... "Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma". Department of ... "Thyroid hormone-induced oxidative stress triggers nuclear factor-kappaB activation and cytokine gene expression in rat liver". ...
"The Goldyne Savad Institute for Gene Therapy, Hadassah Hebrew University Hospital,; Galun E, Axelrod JH. Dijupuk 2010-07-30.. ... angiotensinogen, sawijining hormon kang duwé peran kanggo ngundhakaké tekanan getih nalika diaktivasi déning renin, sawijining ... "Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.". Department of ... "Thyroid hormone-induced oxidative stress triggers nuclear factor-kappaB activation and cytokine gene expression in rat liver." ...
Faktor PTA bahasa Indonesia, ensiklopedia bebas
Angiotensinogen · Caspase · F12 · Kimotripsinogen · Pepsinogen · Proelastase · Prokarboksipolipeptidase · Prolipase · ... Kato A, Asakai R, Davie EW, Aoki N (1989). "Factor XI gene (F11) is located on the distal end of the long arm of human ... Asakai R, Davie EW, Chung DW (1987). "Organization of the gene for human factor XI". Biochemistry. 26 (23): 7221-8. doi:10.1021 ...
Enzim katalase bahasa Indonesia, ensiklopedia bebas
Angiotensinogen · Caspase · F12 · Kimotripsinogen · Pepsinogen · Proelastase · Prokarboksipolipeptidase · Prolipase · ... Gene ontology. Molecular function. • homodimerisasi protein. • aminoacylase activity. • peroxidase activity. • metal ion ...
Gene transcriptions/Elements/Angiotensinogen core promoters - Wikiversity
Main articles: Genes/Human and Human genes. "[T]he core promoter element 1 (AGCE1) of the human angiotensinogen gene (AGT) ... ... Gene transcriptions/Elements/Angiotensinogen core promoters. From Wikiversity. , Gene transcriptions/Elements(Redirected from ... is an example of a core promoter element that may occur in a DNA sequence for only one gene (the human angiotensinogen gene ... A1BG gene transcriptions[edit , edit source]. Main article: Gene transcriptions/A1BG. An AGCE1 occurs at 3-ATC-5, in the ...
Agt - Angiotensinogen precursor - Mus musculus (Mouse) - Agt gene & protein
... based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.,p>,a href=/help/gene_centric_isoform_ ... AngiotensinogenAdd BLAST. 453. ,p>This subsection of the PTM / Processing section describes the position and length of an ... "A redox switch in angiotensinogen modulates angiotensin release.". Zhou A., Carrell R.W., Murphy M.P., Wei Z., Yan Y., Stanley ... IPR000227 Angiotensinogen. IPR023796 Serpin_dom. IPR000215 Serpin_fam. IPR036186 Serpin_sf. PANTHERi. PTHR11461 PTHR11461, 1 ...
Agt - Angiotensinogen precursor - Rattus norvegicus (Rat) - Agt gene & protein
Gene expression databases. Bgee dataBase for Gene Expression Evolution. More...Bgeei. ENSRNOG00000018445 Expressed in 10 organ( ... AngiotensinogenAdd BLAST. 453. ,p>This subsection of the PTM / Processing section describes the position and length of an ... "A redox switch in angiotensinogen modulates angiotensin release.". Zhou A., Carrell R.W., Murphy M.P., Wei Z., Yan Y., Stanley ... IPR000227 Angiotensinogen. IPR023796 Serpin_dom. IPR000215 Serpin_fam. IPR036186 Serpin_sf. PANTHERi. PTHR11461 PTHR11461, 1 ...
Angiotensinogen Gene and Blood Pressure in the Japanese Population | Hypertension
Backward elimination procedures, in which sex, genotype of the ACE gene, genotype of the angiotensinogen gene, age, body mass ... and MM genotypes of the angiotensinogen gene.. As described in "Results," the effects of the genotype of the angiotensinogen ... the TT genotype of the angiotensinogen gene has been reported to be associated with a higher plasma level of angiotensinogen ... genotype of the ACE gene, genotype of the angiotensinogen gene, age, body mass index, cholesterol, SBP, and DBP were considered ...
Angiotensinogen Gene Knockout Delays and Attenuates Cold-Induced Hypertension | Hypertension
Angiotensinogen Gene Knockout Delays and Attenuates Cold-Induced Hypertension. Zhongjie Sun, Robert Cade, Zhonge Zhang, James ... Angiotensinogen Gene Knockout Delays and Attenuates Cold-Induced Hypertension. Zhongjie Sun, Robert Cade, Zhonge Zhang, James ... Angiotensinogen Gene Knockout Delays and Attenuates Cold-Induced Hypertension. Zhongjie Sun, Robert Cade, Zhonge Zhang, James ... Two groups of wild-type (WT) mice and 2 groups of angiotensinogen gene knockout (Agt-KO) mice (6 per group) were used. After ...
Renal Angiotensinogen Gene Expression and Tubular Atrophy in Diabetic Nephropathy | IntechOpen
Angiotensinogen Gene Promoter Region Variant Modifies Body Size-Ambulatory Blood Pressure Relations in Hypertension |...
Angiotensinogen Gene Promoter Region Variant Modifies Body Size-Ambulatory Blood Pressure Relations in Hypertension. Armindo D ... Angiotensinogen Gene Promoter Region Variant Modifies Body Size-Ambulatory Blood Pressure Relations in Hypertension ... Angiotensinogen Gene Promoter Region Variant Modifies Body Size-Ambulatory Blood Pressure Relations in Hypertension ... Angiotensinogen Gene Promoter Region Variant Modifies Body Size-Ambulatory Blood Pressure Relations in Hypertension ...
"Angiotensinogen Gene Silencing Reduces Lipid Accumulation and Inflamma" by Wenting Xin Carroll
Silencing of Agt gene also suppressed the production of pro-inflammatory adipokines, including interleukin-6 (IL-6), tumor ... As expected, results confirmed that Agt gene silencing significantly reduced the expression of Agt and its hormone product ... We hypothesized that adipocytes-derived angiotensinogen (Agt) played a critical role in adipogenesis and/or lipogenesis as well ... Microarray studies identified several genes involved in lipid metabolism and inflammatory pathways which were down-regulated by ...
Angiotensinogen and transforming growth factor β1: novel genes in the pathogenesis of Crohn's disease | Journal of Medical...
Angiotensinogen and transforming growth factor β1: novel genes in the pathogenesis of Crohns disease ... Angiotensinogen and transforming growth factor β1: novel genes in the pathogenesis of Crohns disease ... A variant in the angiotensinogen gene promoter results in increased peptide production, while transforming growth factor β1 ( ... Results: Angiotensinogen-6 AA genotype was significantly associated with Crohns disease (p = 0.007, OR = 2.38, CI = 1.32-4.32 ...
Angiotensinogen gene polymorphisms : relationship to blood pressure response to antihypertensive treatment. Results from the...
The genotypes of two individual SNPs in the angiotensinogen (AGT) gene and a SNP in the low density lipoprotein receptor (LDLR ... Angiotensinogen gene polymorphisms: relationship to blood pressure response to antihypertensive treatment. Results from the ... We found that SNPs in the angiotensinogen gene were associated with the BP lowering response to atenolol. This study is limited ... one in the APOB gene and one in the AGT gene were related to the reduction in left ventricular mass in the patients treated ...
Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene...
Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from...
A variant of the angiotensinogen gene, M235T, has been associated with essential hypertension in selected subjects from Paris, ... Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P, Clark AJL (1994) Linkage of the angiotensinogen gene to ... Bennett CL, Schrader AP, Moris BJ (1993) Cross-sectional analysis of Met235→Thr variant of angiotensinogen gene in severe ... Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from ...
Increased plasma Angiotensinogen levels and its association with the M235T gene polymorphism and hypertension in Calabar and...
The M235T allele of the angiotensinogen gene is thought to incr.. ... Hypertension results from an interaction of many risk genes and ... The M235T allele of the angiotensinogen gene is thought to increase plasma levels of the angiotensinogen which is associated ... Increased plasma Angiotensinogen levels and its association with the M235T gene polymorphism and hypertension in Calabar and ... The angiotensinogen is an important substrate for renin in the RAAS that is finally converted into angiotensin II that plays a ...
Molecular regulation of plasma and tissue angiotensinogen | SpringerLink
High Molecular Weight Form Angiotensinogen Gene Renin System Renin Substrate Angiotensinogen mRNA These keywords were added by ... hybridization of the angiotensinogen gene to chromosome band 1q4, the same region as the human renin gene. Hum Genet1990, 84: ... Gaillard I, Clauser E, Corvol P: Structure of human angiotensinogen gene. DNA1989, 8: 87 - 89.PubMedCrossRefGoogle Scholar ... Restriction fragment length polymorphisms of the angiotensinogen gene in inbred rat strains and mapping of the gene on ...
Hyperglycemia modulates angiotensinogen gene expression<...
title = "Hyperglycemia modulates angiotensinogen gene expression",. abstract = "Elevated plasma angiotensinogen (AGT) levels ... Hyperglycemia modulates angiotensinogen gene expression. Ilan Gabriely, Xiao Man Yang, Jane A. Cases, Xiao Hui Ma, Luciano ... Hyperglycemia modulates angiotensinogen gene expression. / Gabriely, Ilan; Yang, Xiao Man; Cases, Jane A.; Ma, Xiao Hui; ... Hyperglycemia modulates angiotensinogen gene expression. In: American Journal of Physiology - Regulatory Integrative and ...
WikiGenes - Agt - angiotensinogen (serpin peptidase...
The angiotensinogen gene of Swiss mice is closely linked to a retrovirus-like element. Clouston, W.M. DNA Cell Biol. (1990) [ ... Influence of the angiotensinogen gene on the ovulatory capacity of mice. Hefler, L.A., Gregg, A.R. Fertil. Steril. (2001) [ ... Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Kim, H.S ... These "gene titration" experiments establish that changes in Agt gene expression cause changes in the blood pressures of mice [ ...
AGT Gene - GeneCards | ANGT Protein | ANGT Antibody
Angiotensinogen, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Summaries for AGT Gene Entrez Gene Summary for AGT Gene. * The protein encoded by this gene, pre-angiotensinogen or ... No data available for DME Specific Peptides for AGT Gene Domains & Families for AGT Gene Gene Families for AGT Gene. HGNC:. * ... Aliases for AGT Gene Aliases for AGT Gene. * Angiotensinogen 2 3 3 5 ...
Association between the angiotensinogen gene T174M polymorphism and hypertension risk in the Chinese population: a meta...
No consensus has been reached on the association between the angiotensinogen gene polymorphism T174M and hypertension risk in ... Studies investigating gene-gene interactions, gene-environment interactions, as well as their mutual interactions will also be ... Association between the angiotensinogen gene T174M polymorphism and hypertension risk in the Chinese population: a meta- ... Association between the angiotensinogen gene T174M polymorphism and hypertension risk in the Chinese population: a meta- ...
Angiotensinogen Mutations and Risk for Ischemic Heart Disease, Myocardial Infarction, and Ischemic Cerebrovascular Disease: Six...
Mutations of the Angiotensinogen Gene and the Risk for Heart Disease and Stroke Annals of Internal Medicine; 134 (10): I-5 ... Mutations of the Angiotensinogen Gene and the Risk for Heart Disease and Stroke ... ACE Gene Polymorphism as a Risk Factor for Ischemic Cerebrovascular Disease Annals of Internal Medicine; 127 (5): 346-355 ... To determine whether angiotensinogen mutations are associated with ischemic heart disease, myocardial infarction, and ischemic ...
Angiotensinogen Variants among Resistant Hypertensive Patients
... angiotensinogen, and endothelial nitric oxide synthase genes," DNA and Cell Biology, vol. 30, no. 8, pp. 555-564, 2011. View at ... the main finding was the association of two genetic variants in the angiotensinogen (AGT) gene, the M allele of rs699 and the G ... Angiotensinogen Variants among Resistant Hypertensive Patients. Natalia Ruggeri Barbaro, Vanessa Fontana, and Heitor Moreno ... S. R. S. Freitas, P. H. Cabello, R. S. Moura-Neto et al., "Analysis of renin-angiotensin-aldosterone system gene polymorphisms ...
GMS | 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga | A splicing enhancer in exon 2 is essential for functional...
The gene coding for angiotensinogen is composed of 5 exons. Exon 2 (Ex2) is with 854 nucleotides (nt) the longest exon and ... Indeed, by studying the expression of the mouse angiotensinogen (mAOG) gene by RT-PCR and RNase protection assay (RPA) in ... of mAOG-mRNA which lacked Ex2 confirming alternative splicing of this gene. By expressing a full-length mAOG-gene with a viral ... Angiotensinogen is the natural substrate for renin required for the production of all active peptides of the renin-angiotensin ...
Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. - Immunology
Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. ... Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. ... Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. ... Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate ...
Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans - DRO
Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. Caulfield, Mark, Lavender, ... Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans ... Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans, Journal of clinical ... angiotensinogen. hypertension. genetics. African Caribbeans. Adult. Africa. African Continental Ancestry Group. Aged. Alcohol ...
The relationship among angiotensinogen genes polymorphisms and hs-CRP and coronary artery disease. - PubMed - NCBI
The relationship among angiotensinogen genes polymorphisms and hs-CRP and coronary artery disease.. Zhu M1,2, Lin J1,3, Wang C2 ... angiotensinogen; coronary artery disease; genes polymorphisms; high-sensitivity C-reactive protein; rennin-angiotensin- ... The relationship among angiotensinogen genes polymorphisms and hs‐CRP and coronary artery disease ... The relationship among angiotensinogen genes polymorphisms and hs‐CRP and coronary artery disease ...
High Intensity Interval Training Favourably Affects Angiotensinogen mRNA Expression and Markers of Cardiorenal Health in a Rat...
... a protein encoded by the gene Ren, that cleaves a peptide bond on angiotensinogen, a protein encoded by the gene Agt, resulting ... S. Kimura, J. J. Mullins, B. Bunnemann et al., "High blood pressure in transgenic mice carrying the rat angiotensinogen gene," ... Decreased levels of angiotensinogen using angiotensinogen-antibodies in rats  and Agt-knockout mice  exhibit lower ... A review on hepatic angiotensinogen  discusses the noteworthy influence that angiotensinogen has on blood pressure. ...
Angiotensinogen gene expression is induced by cyclical mechanical stretch in cultured rat cardiomyocytes<...
The angiotensinogen gene was activated 2 to 5 fold after stretch for 3 to 24 hr, as shown by quantitative reverse transcription ... The angiotensinogen gene was activated 2 to 5 fold after stretch for 3 to 24 hr, as shown by quantitative reverse transcription ... The angiotensinogen gene was activated 2 to 5 fold after stretch for 3 to 24 hr, as shown by quantitative reverse transcription ... The angiotensinogen gene was activated 2 to 5 fold after stretch for 3 to 24 hr, as shown by quantitative reverse transcription ...
Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene<...
Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene. In: Hypertension. ... Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene. / Wang, Fen; Demura, ... Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene. Hypertension. 2014 ... title = "Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene", ...
August 1998 - Volume 16 - Issue 8 : Journal of Hypertension
HypertensionM235TPolymorphismsPrecursorPromoterVariantsMutationsRenalLocusMRNA expressionGenotypeExpression of the angiotensinogen geneAlleleCandidate GenesReceptorGeneticRegulation of angiotensinogenMolecularTranscriptionGenotypesSusceptibilityAbstractSerpinT174MDifferentially expressed genesLinkage235T variantProteinsProtein encoded by this geneRatsSNPsRenin mRNAEssentialHumanCardiovascularBlood PressureMusculusAldosteroneSubstratePathwaysKidneyTissues
- Abstract A molecular variant of the angiotensinogen gene with threonine instead of methionine at position 235 (ie, with M235T polymorphism) has been shown to be associated with essential hypertension in Caucasian populations. (ahajournals.org)
- Recently, molecular variants of the human angiotensinogen gene have been reported to be associated with essential hypertension in Caucasian populations. (ahajournals.org)
- 2 Fifteen point mutations in the angiotensinogen gene have been identified, two of which were associated with essential hypertension by sibling-pair analysis: one with threonine instead of methionine at position 235 and one with methionine instead of threonine at position 174. (ahajournals.org)
- In the present study, we investigated whether a molecular variant of the angiotensinogen gene at position 235 was associated with hypertension in the Japanese population. (ahajournals.org)
- A variant of the angiotensinogen gene, M235T, has been associated with essential hypertension in selected subjects from Paris, France and Salt Lake City, Utah. (springer.com)
- We determined whether there was a relationship between the M235T polymorphism of the angiotensinogen gene and the occurrence of essential hypertension using two methods. (springer.com)
- These results suggest that the contribution of variation in the angiotensinogen gene to the occurrence of essential hypertension is less than initially suspected, or may not be constant across populations. (springer.com)
- Bennett CL, Schrader AP, Moris BJ (1993) Cross-sectional analysis of Met 235 →Thr variant of angiotensinogen gene in severe familial hypertension. (springer.com)
- Hypertension results from an interaction of many risk genes and environmental factors. (alliedacademies.org)
- The M235T allele of the angiotensinogen gene is thought to increase plasma levels of the angiotensinogen which is associated with hypertension. (alliedacademies.org)
- This study was designed to measure plasma angiotensinogen levels in an adult population in Calabar and Uyo (South-South), Nigeria in relation to the M235T allele and hypertension. (alliedacademies.org)
- Elevated plasma angiotensinogen (AGT) levels have been demonstrated in insulin-resistant states such as obesity and type 2 diabetes mellitus (DM2), conditions that are directly correlated to hypertension. (elsevier.com)
- We propose that increased AGT gene expression and possibly its production may provide another link between obesity/insulin resistance and hypertension. (elsevier.com)
- Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. (genecards.org)
- No consensus has been reached on the association between the angiotensinogen gene polymorphism T174M and hypertension risk in the Chinese population. (cdc.gov)
- Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. (ox.ac.uk)
- 1 ] evaluated the association between 78 candidate gene polymorphisms and treatment resistant hypertension (TRH). (hindawi.com)
- Analysis of renin-angiotensin-aldosterone system gene polymorphisms in resistant hypertension," Brazilian Journal of Medical and Biological Research , vol. 40, no. 3, pp. 309-316, 2007. (hindawi.com)
- Gene variation in resistant hypertension: multilocus analysis of the angiotensin 1-converting enzyme, angiotensinogen, and endothelial nitric oxide synthase genes," DNA and Cell Biology , vol. 30, no. 8, pp. 555-564, 2011. (hindawi.com)
- Whether the ETBR gene (EDNRB) is involved in genetic predisposition to human salt-sensitive hypertension has not been studied so far. (nih.gov)
- We also screened angiotensinogen gene AGT M235T and angiotensin-converting enzyme insertion/deletion polymorphism ACE I/D and found an association between TT genotype and hypertension. (nih.gov)
- 6. Mutating Genes to Study Hypertension. (routledge.com)
- 9. The Study of Candidate Genes in Hypertension Using Tools of Molecular Biology and Genetic Epidemiology. (routledge.com)
- 10. Angiotensinogen and Hypertension. (routledge.com)
- BP was measured using 24 h ambulatory monitoring, and polymorphisms of the AGT gene that had been previously associated with hypertension and/or plasma angiotensinogen levels were typed. (naver.com)
- ten genes have been identified which cause these monogenic forms of hypertension. (wikipedia.org)
- Overall, however, identifiable single-gene causes of hypertension are uncommon, consistent with a multifactorial cause of essential hypertension. (wikipedia.org)
- Haplotypes of angiotensinogen in essential hypertension. (nii.ac.jp)
- A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affeets basal transcription in vitro' J.Clin.Invest.99. (nii.ac.jp)
- These results suggest that activated generation of angiotensinogen in the brain may be involved in the generation of hypertension in SHR and also suggest that SHR may be regarded as an animal hypertension model due to hyperactivity of the brain renin-angiotensin system. (nii.ac.jp)
- Identification of variant genes that contribute to the development of hypertension is further complicated because the cardiac output and peripheral resistance, are controlled by other intermediary phenotypes. (japi.org)
- Considering the importance of genetics on hypertension and the diversity of the related genes, evaluation of these genes and the study of new genes are necessary. (japi.org)
- It is hoped that by deducting related genes for essential hypertension in individual, will help in prevention of potential patients. (japi.org)
- Through its modulation of salt and water homeostasis, the reninangiotensin system (RAS) is a major regulator of blood pressure.4 Since role of RAS is involved in BP regulation, the genes that encode the components of RAS have been suggested to be promising candidate for understanding the pathophysiology of hypertension. (japi.org)
- We analyzed the association between salt sensitivity in essential hypertension and 8 genetic polymorphisms in 6 genes of the renin-angiotensin aldosterone system. (semanticscholar.org)
- Atrial natriuretic peptide and aldosterone synthase gene in essential hypertension: a case-control study. (semanticscholar.org)
- Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension. (semanticscholar.org)
- Conclusions : Our data suggest that VDR gene Fok I polymorphism is associated with the risk of developing essential hypertension. (ebscohost.com)
- Association of apolipoprotein E gene polymorphism with essential hypertension and its complications. (biomedsearch.com)
- Altered regulation of RAS-related genes has been observed in an animal model of hypertension (spontaneously hypertensive rats - SHRs). (tripdatabase.com)
- Essential arterial hypertension and polymorphism of angiotensinogen M235T gene // J. Cell. (medline.ru)
- Threonines at position 174 and 235 of the angiotensinogen polypeptide chain are related to familial history of hypertension in a Spanish-Mediterranean population. (medline.ru)
- The absorbance values of plasma angiotensinogen were significantly higher in the patients (0.71) with M235T allele than in the controls (0.53). (alliedacademies.org)
- Frequencies of genotype and allele distribution in individual angiotensinogen loci (M235T, G217A, G152A, G-6A, A-20C) did not differ in two patient groups. (cdc.gov)
- In CAD patients, M235T among several AGT gene polymorphisms is associated with elevated hs-CRP levels with AGT C allele as the significant factor for patients with hs-CRP level of more than 1 mg/L. (cdc.gov)
- The M235T and T174M angiotensinogen mutations have been linked to increased risk for ischemic heart and cerebrovascular disease. (annals.org)
- To investigate whether the M235T polymorphism of the angiotensinogen (AGT) gene and the insertion/deletion (I/D) polymorphism of the angiotensin-1 converting enzyme (ACE) gene predict blood pressure response to different antihypertensive agents. (nih.gov)
- The M235T polymorphism of the AGT gene was detected by Tth111I digestion of PCR product. (nih.gov)
- Angiotensinogen M235T variant and salt sensitivity in young normotensive Caucasians. (semanticscholar.org)
- Genotyping for renin (REN G1051A), angiotensinogen (AGT) M235T, insertion/deletion of angiotensin-converting enzyme (ACE I/D), angiotensin II type 1 receptor (AGTR1) A1166C and aldosterone synthase (CYP11B2) C344T polymorphisms were performed using polymerase chain reaction, with further restriction analysis when required. (scielo.br)
- RESEARCH DESIGN AND METHODS In a case-control study, the ACE insertion/deletion (I/D) gene, the angiotensinogen (AGT) gene (M235T), and the angiotensin II (AII) type 1 receptor gene (AT1 A1166C) were examined in 110 Chinese type 2 diabetic patients. (diabetesjournals.org)
- Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease. (medline.ru)
- Angiotensinogen gene polymorphisms : relationship to blood pressure response to antihypertensive treatment. (diva-portal.org)
- Our aim was to determine whether specific single nucleotide polymorphisms (SNPs) in RAAS genes were related to the blood pressure (BP) lowering effect of antihypertensive treatment. (diva-portal.org)
- The relationship among angiotensinogen genes polymorphisms and hs-CRP and coronary artery disease. (cdc.gov)
- To assess the association of gene polymorphisms of angiotensinogen (AGT), the key factor in rennin-angiotensin-aldosterone system (RAAS), with high-sensitivity C-reactive protein (hs-CRP) and coronary artery disease (CAD). (cdc.gov)
- We hypothesized that SNPs (single nucleotide polymorphisms) affecting candidate genes in the RAAS and renal sodium handling pathway may influence initial diuretic responsiveness and affect clinical outcome in non-azotaemic cirrhotic patients with moderate ascites. (clinsci.org)
- We prospectively recruited 176 patients and 245 controls and determined their genetic polymorphisms for 24 SNPs of ten genes involved in the RAAS and renal sodium handling pathway. (clinsci.org)
- Polymorphisms in AGT1R and AGT genes are associated with renal dysfunction and CHD in type 2 diabetes and further support the important role of the RAS in these complications. (biomedcentral.com)
- Patients and methods: Polymorphisms of five RAAS components were determined in 26 gene carriers from a single family with HCM caused by a previously identified myosin binding protein C mutation. (bmj.com)
- Conclusion: Genetic polymorphisms of the RAAS influence penetrance and degree of LVH in 26 gene carriers from one family with HCM caused by a myosin binding protein C mutation. (bmj.com)
- Human genome-wide association studies have demonstrated that polymorphisms in the engulfment and cell motility protein 1 gene ( ELMO1 ) are strongly associated with susceptibility to diabetic nephropathy. (pnas.org)
- Therefore, polymorphisms of candidate genes encoding proteins influencing renal tubular sodium transport, either directly or indirectly through effects on intra-renal hemodynamics, have been associated with differences in blood pressure level. (japi.org)
- Particularly, polymorphisms in genes of the renin-angiotensin-aldosterone system namely angiotensinogen, a n g i o t e n s i n - c o n v e r t i n g e n z y m e (ACE), angiotensin II type I receptor and aldosterone synthase, have been prominent. (japi.org)
- Polymorphisms in two of these genes, namely angiotensinogen and ACE, have been associated with functional differences in the encoded gene products with measures of "sodium sensitivity", as measured by blood pressure response to changes in sodium intake. (japi.org)
- Evaluation of renin-angiotensin-aldosterone system gene polymorphisms. (semanticscholar.org)
- Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients. (ebscohost.com)
- Despite different gene polymorphisms with suggested associations with development or severity or outcome of AKI, definitive conclusions would require replication of associations in independent cohort studies and, preferably a hypothesis-free study design. (biomedcentral.com)
- The search criteria were: Genes OR genotype OR phenotype OR polymorphisms OR allelism OR heredity AND acute kidney failure OR acute kidney injury OR acute kidney insufficiency OR acute renal failure OR acute renal injury OR acute renal insufficiency OR acute nephropathy. (biomedcentral.com)
- This meta-analysis enabled us to obtain a precise estimation of the association between gene polymorphisms on chromosome 1 ( MTHFR , AGT , F5 , IL-10 , LEPR ) and the susceptibility to pre-eclampsia (PE) in order to reach a uniform conclusion. (pubmedcentralcanada.ca)
- However, we do not have sufficient evidence to conclude there is a significant association between other gene polymorphisms and PE. (pubmedcentralcanada.ca)
- As suggested by previous reports, genetic polymorphisms of interleukin (IL)-10, methylenetetrahydrofolate reductase (MTHFR), angiotensinogen (AGT), leptin receptor (LEPR), and factor V (FV) might explain the potential role of genetic factors that affect the development of PE [ 6 - 10 ]. (pubmedcentralcanada.ca)
- Association of seven renin angiotensin system gene polymorphisms with restenosis in patients following coronary stenting Percutaneous coronary intervention, despite being effective for coronary revascularization, causes in-stent restenosis due to neointimal hyperplasia in a large number of patients. (tripdatabase.com)
- Angiotensinogen polymorphisms and elevated blood pressure in the general population: the Copenhagen City Heart Study. (medline.ru)
- Angiotensinogen single nucleotide polymorphisms, elevated blood pressure, and risk of cardiovascular disease. (medline.ru)
- Polymorphisms of renin- angiotensin genes among Nigerians, Jamaicans, and African Americans. (medline.ru)
- Angiotensinogen polymorphisms and acquired atrial fibrillation in Chinese/ J Electrocardiol. (medline.ru)
- However, in both the circulation and in tissues, angiotensinogen is the sole precursor of these peptide hormones. (springer.com)
- The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. (genecards.org)
- Angiotensinogen, a precursor of the octapeptide angiotensin II and an effector of the renin-angiotensin system, is synthesized in numerous rat tissues. (utmb.edu)
- All key components of the RAS also have been localized to the endocrine pancreas, including the precursor angiotensinogen and the angiotensin II type 1 receptor ( 15 , 16 ). (diabetesjournals.org)
- Acetyl Angiotensinogen (1-14),porcine, The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. (adooq.com)
- Angiotensinogen core promoter element 1 (AGCE1) is an example of a core promoter element that may occur in a DNA sequence for only one gene (the human angiotensinogen gene angiotensin). (wikiversity.org)
- The core promoter is the minimal portion of the promoter required to properly initiate gene transcription. (wikiversity.org)
- A variant in the angiotensinogen gene promoter results in increased peptide production, while transforming growth factor β1 (TGFβ1) codon 25 variants demonstrate variable peptide production, predisposing to fibrosis in several organs. (bmj.com)
- The 5'-flanking region of the angiotensinogen promoter was activated after stretch for 24 hr. (elsevier.com)
- 2) cyclical stretch up-regulates expression of the angiotensinogen gene and (3) the increase in promoter activity may contribute to the induction of angiotensinogen mRNA by cyclical stretch. (elsevier.com)
- The AGT gene promoter of each patient was sequenced to identify variants. (elsevier.com)
- By expressing a full-length mAOG-gene with a viral promoter in COS7 cells followed by RPA analysis, we could detect the appearance of both mRNA isoforms in these cells (70% full-length, 30% truncated). (egms.de)
- Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region. (wikipathways.org)
- Each promoter element may be found in at least one gene or isoform. (wikiversity.org)
- The nucleotides between genes ZSCAN22 (GeneID: 342945) and the 5'-end of A1BG, should contain the A1BG promoter. (wikiversity.org)
- Second, we evaluated the role of brain angiotensinogen in the spontaneously hypertensive rat (SHR) by using the HVJ-liposome method to introduce decoy oligodeoxynucleotides of angiotensinogen gene-activating factor into the brain ventrilcle to suppress angiotensinogen gene-activating elements in the promoter region of angiotensinogen gene. (nii.ac.jp)
- The isolation, sequence and structural analysis of the human PEDF gene and its promoter along with its evolutionary conservation and expression in human tissues are now described. (molvis.org)
- Conduct an Australian-based analysis of the angiotensinogen-6 variant in two independent inflammatory bowel disease (IBD) cohorts, and examine the role of angiotensinogen-6 and TGFβ1 codon 25 variants in shaping Crohn's disease phenotype. (bmj.com)
- Deeb SS, Failor RA, Brown BG, Brunzell JD, Albers JJ, Motulsky AG, Wijsman E (1992) Association of apolipoprotein B gene variants with plasma apoB and low density lipoprotein (LDL) cholesterol levels. (springer.com)
- Interestingly, the main finding was the association of two genetic variants in the angiotensinogen ( AGT ) gene, the M allele of rs699 and the G allele of rs5051, and TRH in white but not in African-American subjects. (hindawi.com)
- Factor H gene variants in Japanese: its relation to atypical hemolytic uremic syndrome. (springermedizin.de)
- Thus, extensive studies are required to decipher pathogenicity and the physiological mechanisms of these variants, as well as the contribution of modifier genes and environmental factors to disease phenotypes. (frontiersin.org)
- The objective of this review is to report the history of cardiovascular disease and HCM in South Asians, present previously published pathogenic variants, and introduce current efforts to study HCM using induced pluripotent stem cell-derived cardiomyocytes, next-generation sequencing, and gene editing technologies. (frontiersin.org)
- Epidemiological studies have suggested that genetic variants, including those of the genes for angiotensinogen (AGT) 1 , renin (REN) 2 , angiotensin-converting enzyme (ACE) 3 , angiotensin II receptor type 1 (AGTR1) 4,5 , and aldosterone synthase (CYP11B2) 6 increase the risk for EH. (scielo.br)
- To determine whether angiotensinogen mutations are associated with ischemic heart disease, myocardial infarction, and ischemic cerebrovascular disease. (annals.org)
- Mutations in genes encoding sarcomeric proteins are the molecular basis of this disease. (bmj.com)
- 1- 3 Aetiological mutations in eight cardiac sarcomeric protein genes have been identified, including the cardiac myosin binding protein C (MyBP-C) gene (associated with late onset disease). (bmj.com)
- Novel spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis in ethnic Omani patients. (nih.gov)
- Although it has been known for more than a decade that Marfan syndrome - a dominantly inherited connective tissue disorder characterized by tall stature, arachnodactyly, lens subluxation, and a high risk of aortic aneurysm and dissection - results from mutations in the FBN1 gene, which encodes fibrillin-1, the precise mechanism by which the pleiotropic phenotype is produced has been unclear. (jci.org)
- Mutations in this gene have been associated to psoriasis risk. (wikipedia.org)
- Ellison KE, Ingelfinger JR, Pivor M, Dzau VJ Androgen regulation of rat renal angiotensinogen messenger RNA expression. (springer.com)
- The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. (ucsc.edu)
- Increased activation of the renin-angiotensin system (RAS) may be important in promoting coronary heart disease (CHD) and renal dysfunction, but limited data are available on associations between angiotensin type 1 receptor ( AGT1R ) and angiotensinogen ( AGT ) genotypes in type 2 diabetes. (biomedcentral.com)
- To test whether modest changes in its expression alter the severity of the renal phenotype in diabetic mice, we have generated mice that are type 1 diabetic because they have the Ins2 Akita gene, and also have genetically graded expression of Elmo1 in all tissues ranging in five steps from ∼30% to ∼200% normal. (pnas.org)
- Androgen regulation of rat renal angiotensinogen messenger RNA expression. (semanticscholar.org)
- Mutation of the ld gene leads to limb deformity with renal agenesis. (medscape.com)
- Comparative Analysis of Renin - Angiotensin System (RAS)-Related Gene Expression Between Hypertensive and Normotensive Rats BACKGROUND The renal renin - angiotensin system (RAS) is physiologically important for blood pressure regulation. (tripdatabase.com)
- although the renin gene locus was reported to be associated with high blood pressure in an F 2 population derived from spontaneously hypertensive and Lewis rats, 5 this locus was not associated with high blood pressure in an F 2 population derived from stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. (ahajournals.org)
- Conclusions These results suggest that genetic variation at the angiotensinogen locus may primarily affect arterial stiffness, and therefore pulse pressure. (naver.com)
- Although vertebrates usually have a single renin gene, some strains of mice contain a duplicated renin locus designated as Ren-2 , which is closely linked to the Ren-1 locus ( 1 , 2 ). (physiology.org)
- Human and rat angiotensinogen and renin mRNA expression were also determined. (mdc-berlin.de)
- Tissue-specific mRNA expression of RAAS-related genes and CKD-related clinical markers were examined. (hindawi.com)
- The mRNA expression of a subset of genes was validated by qRT-PCR. (nih.gov)
- DEHP exposure is associated with global changes in mRNA expression, with differentially expressed genes overrepresented in 47 Gene Ontology categories. (nih.gov)
- The clinical data included in the analyses were sex, age, body mass index, cholesterol level, genotype of the angiotensinogen gene, genotype of the angiotensin-converting enzyme gene, and systolic and diastolic blood pressure. (ahajournals.org)
- Multiple regression analysis revealed that only body mass index was a predictor of both diastolic and systolic blood pressure in these 347 subjects, but the genotype of the angiotensinogen gene was identified as a predictor of both diastolic and systolic blood pressure in a subpopulation less than 50 years of age. (ahajournals.org)
- Multiple regression analysis revealed that sex, body mass index, diastolic blood pressure, and genotype of the angiotensin-converting enzyme gene were predictors of left ventricular mass. (ahajournals.org)
- Although subjects with the TT angiotensinogen genotype had significantly greater left ventricular mass than those with either the TM or the MM genotype, the effects of the genotype of the angiotensinogen gene on left ventricular mass were mainly due to effects on blood pressure. (ahajournals.org)
- Moreover, the plasma angiotensinogen concentration was higher in subjects with the TT genotype at position 235 than in subjects with either the TM or the MM genotype. (ahajournals.org)
- Genotype-phenotype analyses were performed for both angiotensinogen-6 and TGFβ1 codon 25. (bmj.com)
- Angiotensinogen-6 AA genotype was significantly associated with Crohn's disease (p = 0.007, OR = 2.38, CI = 1.32-4.32) in cohort 1, but not in the smaller cohort 2 (p = 0.19). (bmj.com)
- A microarray-based minisequencing system was used to genotype 30 SNPs in seven genes in the RAAS. (diva-portal.org)
Expression of the angiotensinogen gene1
- We demonstrate that stimulatory signals can change the DNA methylation status at a CCAAT/enhancer binding protein (CEBP) binding site and a transcription start site and activate expression of the angiotensinogen gene (AGT). (elsevier.com)
- Presence of the angiotensinogen (AGT) -6A allele or the AGT 235T allele were both associated with the most pronounced systolic BP response to atenolol treatment (P =.001 when -6 AA+AG was compared with GG and P =.008 for presence of the 235T variant compared with 235 MM). CONCLUSIONS: We found that SNPs in the angiotensinogen gene were associated with the BP lowering response to atenolol. (diva-portal.org)
- BACKGROUND: The 825T allele of the G-protein beta(3)-subunit gene is associated with increased intracellular signalling and adipogenesis in experimental studies. (biomedsearch.com)
- 22. Yamakawa-Kobayashi K., Arinami T., Hamaguchi H. Absence of association of angiotensinogen gene T235 allele with increased risk of coronary heart disease in Japanese // Lancet. (medline.ru)
- Gene expression profiling technology provides an unbiased approach to identifying candidate genes for mental disorders. (biomedcentral.com)
- These differentially expressed, candidate genes are neural correlates of suicide, not necessarily causal. (biomedcentral.com)
- While suicide is a complex endpoint with many pathways, these candidate genes provide entry points for future studies of molecular mechanisms and genetic association studies to test causality. (biomedcentral.com)
- Additional analysis using mouse adipogenesis PCR arrays detected lower expression levels of adipogenic/lipogenic genes, such as peroxisome proliferator activated receptor gamma (Pparg), sterol regulatory element binding transcription factor 1 (Srebf1), adipogenin (Adig), and fatty acid binding protein 4 (Fabp4). (tennessee.edu)
- The association of the angiotensinogen-6 variant with Crohn's disease supports a potential role for angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in disease treatment. (bmj.com)
- This gene expression could be completely suppressed by losartan, a specific antagonist of angiotensin II receptor. (elsevier.com)
- Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. (wikipathways.org)
- Background : The vitamin D receptor (VDR) gene serves as a good candidate gene for susceptibility to several diseases. (ebscohost.com)
- Interactions between gender and the angiotensin type 1 receptor gene polymorphism. (biomedsearch.com)
- The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. (wikipedia.org)
- Genes encoding components of the renin-angiotensin system are attractive candidates for the genetic basis of cardiovascular diseases. (ahajournals.org)
- Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
- Until recently, the role of genetic susceptibility and gene-environment interactions in preterm birth has largely been unexplored. (nap.edu)
- After identifying responsible genes, we have to know the mechanism of an interplay between genetic and environmental factors, and then to know what kind of environmental factor (s) should be modified to prevent the onset of the diseases. (nii.ac.jp)
- 3 The most common genetic variation in RAAS is the insertion/deletion polymorphism of the ACE gene, 4 and its association with BP has been reported to be dependent on sex and race/ethnicity. (bmj.com)
- Genetic and transgenic analyses indicate these differences appear to be mediated by cis -acting sequences located close to the structural gene (reviewed in Ref. 26 ). (physiology.org)
Regulation of angiotensinogen1
- Glucocorticoid and thyroid hormone regulation of angiotensinogen gene expression in a pancreatic islet cell line. (utmb.edu)
- This molecular level analysis suggests that diagnostic specific genes predominate to shared genes in common among suicide vs. non-suicide groups. (biomedcentral.com)
- Microarray studies identified several genes involved in lipid metabolism and inflammatory pathways which were down-regulated by Agt gene inactivation, such as glycerol-3-phosphate dehydrogenase 1 (Gpd1), carboxylesterase 3 (Ces3), retinol saturase (Retsat), serum amyloid A 3 (Saa3), nucleotide-binding oligomerization domain containing 1 (Nod1), signal transducer and activator of transcription 1 (Stat1) and chemokine (C-X-C motif) ligand 12 (Cxcl12). (tennessee.edu)
- The angiotensinogen gene was activated 2 to 5 fold after stretch for 3 to 24 hr, as shown by quantitative reverse transcription polymerase chain reaction. (elsevier.com)
- Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. (abcam.com)
- NF-κB2 (p100/p52), a member of the NF-κB/Rel family of transcription factors, is involved in the regulation of a variety of genes important for immune function. (asm.org)
- NF-κB/Rel proteins comprise a family of inducible transcription factors which control the expression of numerous genes involved in the immune, inflammatory, and acute-phase responses (for reviews, see references 3 , 5 , and 18 ). (asm.org)
- Acetaldehyde, increased redox cellular state and ROS activate transcription factors, which in turn activate genes for lipid biosynthesis and offer protection of hepatocytes from alcohol toxicity. (mdpi.com)
- Resolution of increased reactive oxygen species requires increased expression of genes responsible for dismutation of increased ROS which is partially achieved by IL-6 mediated activation of signal transducers and activators of transcription 3 (STAT3). (mdpi.com)
- Transcription of eukaryotic genes is believed to be reasonably well understood. (wikiversity.org)
- During nephrogenesis, multiple genes, transcription factors, and growth factors control the essential interaction between the ureteric bud and the metanephric mesenchyme. (medscape.com)
- Hub genes with a high degree of connectivity in the PPI network are significantly enriched in positive regulation of transcription. (frontiersin.org)
- The change in systolic and diastolic blood pressure achieved by each agent was analysed for association with genotypes at the AGT and ACE gene loci. (nih.gov)
- Background Many previous studies have investigated whether there is an association between genotypes at the angiotensinogen (AGT) gene and hypertensive status, but few have incorporated quantitative data. (naver.com)
- In cirrhotic patients with moderate ascites, multivariate analysis showed that diuretic unresponsiveness was predicted by a high basal plasma aldosterone level, by a high aldosterone/renin ratio and by specific risk genotypes of ACE (gene encoding angiotensin-converting enzyme), CYP11B2 (gene encoding aldosterone synthase) and ADDA (gene encoding α-adducin). (clinsci.org)
- Results: There was a non-biased distribution of pro-LVH genotypes in the gene carriers. (bmj.com)
- Individual susceptibility to develop AKI and to influence disease progression have been studied using candidate gene association studies. (biomedcentral.com)
- The hypothesis of a shared causation for suicide suggests common pathways and genes may function as susceptibility factors in both disorders. (biomedcentral.com)
- abstract = "The effect of cyclical mechanical stretch on angiotensinogen gene expression was examined using a neonatal rat cardiocyte culture system. (elsevier.com)
-  GeneID: 183 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ] has the official symbol AGT. (wikiversity.org)
- angiotensinogen (serpin peptidase. (wikigenes.org)
- Subsequently, the factor was isolated and its cDNA cloned (8,9), demonstrating it to be a 50 kDa protein exhibiting sequence homology with members of the serpin gene family. (molvis.org)
Differentially expressed genes2
- This study poses the question: to what extent are differentially expressed genes for suicide a diagnostic specific set of genes (bipolar disorder vs. schizophrenia) vs. a shared common pathway? (biomedcentral.com)
- Analysis of larger data sets pooled from independent studies increase the statistical power to find differentially expressed genes with small effect sizes in microarray studies. (biomedcentral.com)
- Enhanced blood pressure response to mild sodium reduction in subjects with the 235T variant of the angiotensinogen gene. (semanticscholar.org)
- The cellular response in signal transduction cascades involves alteration of the expression of effector genes or activation/inhibition of targeted proteins. (wikipedia.org)
Protein encoded by this gene2
- Although insulin infusion suppressed AGT gene expression in fat and liver of lean rats, the obese rats demonstrated resistance to this effect of insulin. (elsevier.com)
- Resistance to the suppressive effect of insulin on AGT expression in obese rats may potentiate the effect of nutrients on AGT gene expression. (elsevier.com)
- Since nothing is known about the control of sodium and water excretion in these rats, this study was performed to compare pressure-natriuresis relationships in hypertensive dTGR and normotensive control rats harboring only the human renin gene (hREN), in order to determine how the pressure-natriuresis relationship is reset in hypertensive dTGR. (mdc-berlin.de)
- Activation of the brain angiotensin system by in vivo human angiotensin converting enzyme gene transfer in rats. (nii.ac.jp)
- We selected 95 case-control studies investigating 5 genes ( MTHFR , AGT , F5 , IL-10 , and LEPR ) with 8 SNPs. (pubmedcentralcanada.ca)
- Since Ex2 is essential for angiotensinogen function, interfering with this splicing process might be of therapeutic interest. (egms.de)
- Assignment by in situ hybridization of the angiotensinogen gene to chromosome band 1q4, the same region as the human renin gene . (springer.com)
- Together, these developments present an exciting opportunity to address unanswered questions related to the complex contributions of genes, the environment, and gene-gene and gene-environment interactions to complex human diseases, including preterm birth. (nap.edu)
- The hypertensive double transgenic rat harboring both the human renin and human angiotensinogen genes (dTGR) offers a unique opportunity to study the human renin-angiotensin system in an experimental animal model. (mdc-berlin.de)
- Both human and rat renin and angiotensinogen mRNA were expressed in the kidneys of dTGR. (mdc-berlin.de)
- The reduced excretory function in dTGR depends on hREN and human angiotensinogen gene expression and is intrinsic to the kidney as opposed to extrarenal regulators. (mdc-berlin.de)
- PEDF is also of interest since its gene is localized to human chromosome 17p (14), a region to which numerous hereditaty diseases have been mapped. (molvis.org)
- We thus felt it of importance to characterize the human PEDF gene and now report its structural organization. (molvis.org)
- Moreover, we have investigated the evolutionary conservation of PEDF in a number of phylogenetically-related species and determined the expression of the gene in human tissues including major regions of the brain. (molvis.org)
- Leucyl/cystinyl aminopeptidase, also known as cystinyl aminopeptidase (CAP), insulin-regulated aminopeptidase (IRAP), human placental leucine aminopeptidase (PLAP), oxytocinase, and vasopressinase, is an enzyme of the aminopeptidase group that in humans is encoded by the LNPEP gene. (wikipedia.org)
- Gene therapy for cardiovascular disease:is gene therapy a real medicine in next millennium? (nii.ac.jp)
- Background: Angiotensinogen (AGT) constitutes a central component of the renin-angiotensin system that controls the systemic blood pressure and several other cardiovascular functions and may play an important role in atherosclerosis pathways. (ebscohost.com)
- HYPOTHESIS/INTRODUCTION: A polymorphic marker within the angiotensin- converting enzyme (ACE) gene has been associated with circulating and tissue ACE activity and with a variety of forms of cardiovascular disease. (biomedsearch.com)
- Gardes J, Bouhnik J, Clauser E, Corvol P, Ménard J (1989) Role of angiotensinogen in blood pressure homeostasis. (springer.com)
- The angiotensinogen is an important substrate for renin in the RAAS that is finally converted into angiotensin II that plays a key role in the control of blood pressure. (alliedacademies.org)
- Blood pressure fell only in the SHR as brain angiotensinogen level decreased. (nii.ac.jp)
- Angiotensinogen gene-activating elements regulate blood pressure in the brain'Circulation Research. (nii.ac.jp)
- 2006, Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome, J Lab Clin Med 2006 147(2) 91-5. (ucsc.edu)
- In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). (bioon.com.cn)
- The gene has a critical role in regulating the renin-angiotensin system (RAS) influencing the regulation of blood pressure. (ebscohost.com)
- Drops in blood pressure or blood volume lead to secretion of renin, a protease, which hydrolyses angiotensinogen to angiotensin I (Ang I). Ang I is converted to Angiotensin II (Ang II), a strong vasoconstrictor, by angiotensin converting enzyme (ACE). (frontiersin.org)
- a-l-antitrypsin, a-1-antichymotrypsin), others have evolved alternate functions which include hormone transport (thyroxine-binding globulin, corticosteroid-binding globulin) and blood pressure regulation (angiotensinogen) (1-4). (molvis.org)
- It is unknown whether this difference is related to potential ethnic differences in the relative contribution of genes and environment to population variation in blood pressure and underlying hemodynamics. (biomedsearch.com)
- 21. Iwai N., Shimoike H., Ohmichi N., Kinoshita M. Angiotensinogen gene and blood pressure in the Japanese population. (medline.ru)
- angiotensinogen [Mus musculus]. (jax.org)
- Angiotensinogen is the natural substrate for renin required for the production of all active peptides of the renin-angiotensin system. (egms.de)
- This study aimed to elucidate potential candidate hub genes and key pathways related to BD in a pre-frontal cortex sample. (frontiersin.org)
- Taken together, the identification of these 30 hub genes and enrichment pathways might have important clinical implications for BD treatment and diagnosis. (frontiersin.org)
- An important gene associated with Aromatase Excess Syndrome is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Steroid hormone biosynthesis and Peptide hormone metabolism . (malacards.org)
- Mutation of the formin IV gene leads only to kidney abnormalities. (medscape.com)