Angiotensinogen
An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver and secreted into blood circulation. Angiotensinogen is the inactive precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.
Angiotensins
Renin-Angiotensin System
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Renin
Angiotensin II
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Peptidyl-Dipeptidase A
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
Hypertension
Angiotensin I
Receptor, Angiotensin, Type 1
Mestranol
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Receptors, Angiotensin
Kidney
Polymorphism, Genetic
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Methyltestosterone
Receptor, Angiotensin, Type 2
Animals, Genetically Modified
Genotype
Losartan
Rats, Inbred WKY
Rats, Inbred SHR
Rats, Transgenic
Kidney Tubules, Proximal
Rats, Sprague-Dawley
Eosinophil Major Basic Protein
Subfornical Organ
Alleles
Angiotensin II Type 1 Receptor Blockers
Captopril
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
Gene Expression Regulation
Glomerulonephritis, IGA
Gene Frequency
Water Pollutants, Chemical
Vitellogenins
Phospholipoglycoproteins produced in the fat body of egg-laying animals such as non-mammalian VERTEBRATES; ARTHROPODS; and others. Vitellogenins are secreted into the HEMOLYMPH, and taken into the OOCYTES by receptor-mediated ENDOCYTOSIS to form the major yolk proteins, VITELLINS. Vitellogenin production is under the regulation of steroid hormones, such as ESTRADIOL and JUVENILE HORMONES in insects.
Ethinyl Estradiol
Nidovirales Infections
Estrogens
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Angiotensinogen gene polymorphisms M235T/T174M: no excess transmission to hypertensive Chinese. (1/836)
The gene encoding angiotensinogen (AGT) has been widely studied as a candidate gene for hypertension. Most studies to date have relied on case-control analysis to test for an excess of AGT variants among hypertensive cases compared with normotensive controls. However, with this design, nothing guarantees that a positive finding is due to actual allelic association as opposed to an inappropriate control population. To avoid this difficulty in our study of essential hypertension in Anqing, China, we tested AGT variants using the transmission/disequilibrium test, a procedure that bypasses the need for a control sample by testing for excessive transmission of a genetic variant from parents heterozygous for that variant. We analyzed two AGT polymorphisms, M235T and T174M, which have been associated with essential hypertension in whites and Japanese, using data on 335 hypertensive subjects from 315 nuclear families and their parents. Except in the group of subjects younger than 25 years, M235 and T174 were the more frequently transmitted alleles. We found that 194 parents heterozygous for M235T transmitted M235 106 times (P=0.22) and that 102 parents heterozygous for T174M transmitted T174 60 times (P=0.09). Stratifying offspring by gender, M235 and T174 were transmitted 60 of 106 times (P=0.21) and 44 of 75 times (P=0.17), respectively, in men, and 46 of 88 times (P=0.75) and 16 of 27 times (P=0.44), respectively, in women. Our results were also negative in all age groups and for the affected offspring with blood pressure values >/=160/95 mm Hg. Thus, this study provides no evidence that either allele of M235T or T174M contributes to hypertension in this Chinese population. (+info)Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis. (2/836)
Insulin-like growth factor (IGF)-1 inhibits apoptosis, but its mechanism is unknown. Myocyte stretching activates p53 and p53-dependent genes, leading to the formation of angiotensin II (Ang II) and apoptosis. Therefore, this in vitro system was used to determine whether IGF-1 interfered with p53 function and the local renin-angiotensin system (RAS), decreasing stretch-induced cell death. A single dose of 200 ng/ml IGF-1 at the time of stretching decreased myocyte apoptosis 43% and 61% at 6 and 20 hours. Ang II concentration was reduced 52% at 20 hours. Additionally, p53 DNA binding to angiotensinogen (Aogen), AT1 receptor, and Bax was markedly down-regulated by IGF-1 via the induction of Mdm2 and the formation of Mdm2-p53 complexes. Concurrently, the quantity of p53, Aogen, renin, AT1 receptor, and Bax was reduced in stretched myocytes exposed to IGF-1. Conversely, Bcl-2 and the Bcl-2-to-Bax protein ratio increased. The effects of IGF-1 on cell death, Ang II synthesis, and Bax protein were the consequence of Mdm2-induced down-regulation of p53 function. In conclusion, the anti-apoptotic impact of IGF-1 on stretched myocytes was mediated by its capacity to depress p53 transcriptional activity, which limited Ang II formation and attenuated the susceptibility of myocytes to trigger their endogenous cell death pathway. (+info)Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen. (3/836)
Angiotensin produced systemically or locally in tissues such as the brain plays an important role in the regulation of blood pressure and in the development of hypertension. We have established transgenic rats [TGR(ASrAOGEN)] expressing an antisense RNA against angiotensinogen mRNA specifically in the brain. In these animals, the brain angiotensinogen level is reduced by more than 90% and the drinking response to intracerebroventricular renin infusions is decreased markedly compared with control rats. Blood pressure of transgenic rats is lowered by 8 mmHg (1 mmHg = 133 Pa) compared with control rats. Crossbreeding of TGR(ASrAOGEN) with a hypertensive transgenic rat strain exhibiting elevated angiotensin II levels in tissues results in a marked attenuation of the hypertensive phenotype. Moreover, TGR(ASrAOGEN) exhibit a diabetes insipidus-like syndrome producing an increased amount of urine with decreased osmolarity. The observed reduction in plasma vasopressin by 35% may mediate these phenotypes of TGR(ASrAOGEN). This new animal model presenting long-term and tissue-specific down-regulation of angiotensinogen corroborates the functional significance of local angiotensin production in the brain for the central regulation of blood pressure and for the pathogenesis of hypertension. (+info)Local renin-angiotensin system is involved in K+-induced aldosterone secretion from human adrenocortical NCI-H295 cells. (4/836)
NCI-H295, a human adrenocarcinoma cell line, has been proposed as a model system to define the role of the renin-angiotensin system in the regulation of aldosterone production in humans. Because the precise cellular localization of the components of the renin-angiotensin system in human adrenal cortical cells remains unclear, we investigated their localization in this defined cell system. NCI-H295 cells expressed both angiotensinogen and renin as shown by reverse transcriptase polymerase chain reaction and immunohistochemistry. Human angiotensin-converting enzyme (ACE) was not detectable by immunocytochemistry, ACE binding, or reverse transcriptase polymerase chain reaction. However, 3.5 mmol/L K+ stimulated the formation of both angiotensin I and angiotensin II 1. 9- and 2.5-fold, respectively, and increased aldosterone release 3. 0-fold. The K+-induced stimulation of aldosterone release was decreased by captopril and enalaprilat (24% and 26%, respectively) and by the angiotensin type 1 (AT1)-receptor antagonist losartan (28%). Angiotensin II-induced stimulation of aldosterone release was abolished by losartan treatment. Specific [125I]Sar1-angiotensin II binding was detected by receptor autoradiography. The binding of [125I]Sar1-angiotensin II was completely displaced by the AT1 antagonist losartan but not by the AT2 receptor ligand PD 123319, confirming the expression of angiotensin II AT1 receptors in NCI-H295 cells. Our results demonstrate that NCI-H295 cells express most of the components of the renin-angiotensin system. Our failure to detect ACE, however, suggests that the production of angiotensin II in NCI-H295 cells may be ACE independent. NCI-H295 cells are able to produce angiotensin II, and K+ increases aldosterone secretion in part through an angiotensin-mediated pathway. The production of angiotensin II in NCI-H295 cells demonstrates that this human cell line can be useful to characterize the role of locally produced angiotensin II in the regulation of aldosterone release. (+info)The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy. (5/836)
BACKGROUND: Inhibition of angiotensin action, pharmacologically or genetically, during the neonatal period leads to renal anomalies involving hypoplastic papilla and dilated calyx. Recently, we documented that angiotensinogen (Agt -/-) or angiotensin type 1 receptor nullizygotes (Agtr1 -/-) do not develop renal pelvis nor ureteral peristaltic movement, both of which are essential for isolating the kidney from the high downstream ureteral pressure. We therefore examined whether these renal anomalies could be characterized as "obstructive" nephropathy. METHODS: Agtr1 -/- neonatal mice were compared with wild-type neonates, the latter subjected to surgical complete unilateral ureteral ligation (UUO), by analyzing morphometrical, immunohistochemical, and molecular indices. Agtr1 -/- mice were also subjected to a complete UUO and were compared with wild-type UUO mice by quantitative analysis. To assess the function of the urinary tract, baseline pelvic and ureteral pressures were measured. RESULTS: The structural anomalies were qualitatively indistinguishable between the Agtr1 -/- without surgical obstruction versus the wild type with complete UUO. Thus, in both kidneys, the calyx was enlarged, whereas the papilla was atrophic; tubulointerstitial cells underwent proliferation and also apoptosis. Both were also characterized by interstitial macrophage infiltration and fibrosis, and within the local lesion, transforming growth factor-beta 1, platelet-derived growth factor-A and insulin-like growth factor-1 were up-regulated, whereas epidermal growth factor was down-regulated. Moreover, quantitative differences that exist between mutant kidneys without surgical obstruction and wild-type kidneys with surgical UUO were abolished when both underwent the same complete surgical UUO. The hydraulic baseline pressure was always lower in the pelvis than that in the ureter in the wild type, whereas this pressure gradient was reversed in the mutant. CONCLUSION: The abnormal kidney structure that develops in neonates during angiotensin inhibition is attributed largely to "functional obstruction" of the urinary tract caused by the defective development of peristaltic machinery. (+info)Molecular mechanism(s) of action of isoproterenol on the expression of the angiotensinogen gene in opossum kidney proximal tubular cells. (6/836)
BACKGROUND: beta-adrenoceptors are present in the renal proximal tubules. We have previously reported that isoproterenol stimulates the accumulation of intracellular cAMP and the expression of the angiotensinogen (ANG) gene in opossum kidney (OK) proximal tubular cells via the beta 1-adrenoceptor. We hypothesized that the molecular mechanism(s) of action of isoproterenol on the expression of the ANG gene is mediated via the interaction of the phosphorylated cAMP-responsive element binding protein (CREB) and the cAMP-responsive element (CRE; that is, ANG N-806/-779) in the 5'-flanking region of the rat ANG gene. METHODS: The fusion genes containing the putative ANG-CRE of the rat ANG gene inserted upstream of the rat ANG basal promoter (ANG N-53/+18) fused to a human growth hormone (hGH) gene as reporter were stably cotransfected, with or without the plasmid containing the cDNA for 43 kDa CREB, into the OK cells. The effect of various agonists and antagonists of adrenoceptors on the expression of the fusion genes was evaluated by the amount of immunoreactive hGH secreted into the culture medium. The interactions of OK cellular nuclear protein(s) with the ANG N-806/779 were determined by gel mobility shift assays and by Southwestern and Western blot analysis. RESULTS: The addition of isoproterenol, forskolin, or 8-Bromo-cAMP (8-Br-cAMP) stimulated the expression of pOGH (ANG N-806/-779/-53/+18) by 135, 150, and 160%, respectively, but not mutants of the ANG N-806/-779. The stimulatory effect of isoproterenol was blocked in the presence of propranolol, Rp-cAMP, and atenolol, but not by the presence of stauro-sporine, U73122, and ICI 118,551. Transient transfection of the plasmid containing the cDNA for the catalytic subunit of protein kinase A further enhanced the stimulatory effect of 43 kDa CREB on the expression of the fusion gene. The gel mobility shift assays revealed the the nuclear protein(s) of OK cells binds to the radioactive-labeled ANG N-806/-779. The binding of the labeled ANG N-806/-779 to the OK cell nuclear protein(s) was displaced by unlabeled ANG N-806/-779, but not by the CRE of the somatostatin gene, the CRE of the tyrosine amino-transferase gene, or the mutants of the ANG N-806/-779. Southwestern blot analysis revealed that the labeled ANG N-806/-779 binds to two nuclear species of 43 and 35 kDa proteins. Western blot analysis, however, revealed that rabbit polyclonal antibodies against the 43 kDa CREB interacted with only the 43 kDa molecular species but not with the 35 kDa species. CONCLUSION: These studies demonstrate that the stimulatory effect of isoproterenol on the expression of the ANG gene may be mediated, at least in part, via the interaction of the phosphorylated CREB and the CRE in the 5'-flanking region of the rat ANG gene. The novel 35 kDa nuclear protein that is immunologically different from the 43 kDa CREB may also play a role in the expression of the ANG gene. (+info)Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. (7/836)
Here we investigate the biochemical, molecular, and cellular changes directed toward blood pressure homeostasis that occur in the endocrine branch of the renin-angiotensin system of mice having one angiotensinogen gene inactivated. No compensatory up-regulation of the remaining normal allele occurs in the liver, the main tissue of angiotensinogen synthesis. No significant changes occur in expression of the genes coding for the angiotensin converting enzyme or the major pressor-mediating receptor for angiotensin, but plasma renin concentration in the mice having only one copy of the angiotensinogen gene is greater than twice wild-type. This increase is mediated primarily by a modest increase in the proportion of renal glomeruli producing renin in their juxtaglomerular apparatus and by four times wild-type numbers of renin-producing cells along afferent arterioles of the glomeruli rather than by up-regulating renin production in cells already committed to its synthesis. (+info)In vivo enzymatic assay reveals catalytic activity of the human renin precursor in tissues. (8/836)
The aspartyl protease renin is secreted into the circulation of mammals in 2 forms: the proteolytically processed active form of the enzyme and the precursor form, prorenin. Prorenin has no detectable enzymatic activity in the circulation, but it is the exclusive form of the enzyme produced by several tissues that also produce the other components of the renin enzymatic cascade (renin-angiotensin system). To test whether prorenin might be enzymatically active in these tissues, transgenic mice expressing the human renin substrate (angiotensinogen) exclusively in the pituitary gland were mated to mice expressing either active human renin or prorenin in the same tissue. Measurement of in vivo product formation in pituitary glands of double-transgenic mice revealed that human prorenin was enzymatically active, and Western blot analysis demonstrated that this prorenin was in the precursor form with its prosegment attached. This in vivo enzymatic assay demonstrates for the first time that human prorenin can be activated within tissues by nonproteolytic means, where it could contribute to the activity of a localized renin-angiotensin system. (+info)
Presence of angiotensinogen messenger RNA in various cultured cell lines. | Hypertension
Glucocorticoid and thyroid hormone regulation of angiotensinogen gene expression in a pancreatic islet cell line.<...
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Hyperglycemia modulates angiotensinogen gene expression<...
Vasoactive intestinal peptide down-regulates the intrahepatic renin-angiotensin system in the anaesthetized rat | Clinical...
Recombinant Human Angiotensinogen protein (ab191974)
Acetyl Angiotensinogen (1-14), porcine | Buy Acetyl Angiotensinogen (1-14), porcine from Supplier AdooQ®
Angiotensinogen gene polymorphisms : relationship to blood pressure response to antihypertensive treatment. Results from the...
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Pesquisa | Portal Regional da BVS
Association of Angiotensin Converting Enzyme Insertion/Deletion and Angiotensinogen T235 Polymorphisms with Risk of Essential...
HDAC9 is an epigenetic repressor of kidney angiotensinogen establishing a sex difference | Biology of Sex Differences | Full...
Serval - Blood pressure and renin-angiotensin system resetting in transgenic rats with elevated plasma Val5-angiotensinogen.
Angiotensinogen Detection
Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular...
AGT Gene - GeneCards | ANGT Protein | ANGT Antibody
Reactome | Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)
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Angiotensinogen Human ELISA | BioVendor
RBRC01120
Angiotensinogen secretion by single rat pituitary cells: detection by a reverse haemolytic plaque assay and cell identification...
Urinary Angiotensinogen and Risk of Severe AKI | American Society of Nephrology
Down-regulation of the intrarenal renin-angiotensin system in the aging rat. | American Society of Nephrology
PRIME PubMed | Augmented circadian rhythm of the intrarenal renin-angiotensin systems in anti-thymocyte serum nephritis rats
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BIOETYMOLOGY : ORIGIN IN BIOMEDICAL TERMS: angiotensinogen
Angiotensinogen Definition and Examples - Biology Online Dictionary
Renin FRET Substrate I
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Gentaur Molecular :Molecular Innovations \ RENIN PRORENIN Rat Renin Prorenin Double Depleted Plasma \ RPLA-SC-PREN
A novel role for vitamin D: modulation of expression and function of the local renin-angiotensin system in mouse pancreatic...
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Renal Denervation in Treatment Resistant Hypertension - Full Text View - ClinicalTrials.gov
ONLINE SUPPLEMENTAL MATERIAL. Allele-Specific Expression of Angiotensinogen in Human Subcutaneous Adipose Tissue - PDF
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Biochemical cascade
"Interleukin-6 Mediates Angiotensinogen Gene Expression during Liver Regeneration". PLOS ONE. 8 (7): e67868. Bibcode:2013PLoSO ... Dzau, VJ; Herrmann, HC (15-22 February 1982). "Hormonal control of angiotensinogen production". Life Sciences. 30 (7-8): 577-84 ... Angiotensinogen expression Regenerate itself by hepatocyte mitosis Via STAT and Gab1: RAS/MAPK, PLC/IP3 and PI3K/FAK Cell ...
Serpin
Sethi AA, Nordestgaard BG, Tybjaerg-Hansen A (July 2003). "Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk ... December 1994). "Angiotensinogen-deficient mice with hypotension". The Journal of Biological Chemistry. 269 (50): 31334-31337. ... Jeunemaitre X, Gimenez-Roqueplo AP, Célérier J, Corvol P (1999). "Angiotensinogen variants and human hypertension". Current ... Dickson ME, Sigmund CD (July 2006). "Genetic basis of hypertension: revisiting angiotensinogen". Hypertension. 48 (1): 14-20. ...
African Society of Hypertension (AfSoH) Initiative
Dickson ME, Sigmund CD (July 2006). "Genetic basis of hypertension: revisiting angiotensinogen". Hypertension. 48 (1): 14-20. ...
Essential hypertension
One of these genes is the angiotensinogen (AGT) gene, studied extensively by Kim et al. They showed that increasing the number ... Dickson ME, Sigmund CD (July 2006). "Genetic basis of hypertension: revisiting angiotensinogen". Hypertension. 48 (1): 14-20. ...
Angiotensin
Angiotensinogen is also known as renin substrate. It is cleaved at the N-terminus by renin to result in angiotensin I, which ... Angiotensinogen is an α-2-globulin synthesized in the liver and is a precursor for angiotensin, but has also been indicated as ... Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-... Plasma angiotensinogen levels are increased by plasma corticosteroid, ... In mice with a full body deficit of angiotensinogen, the effects observed were low newborn survival rate, stunted body weight ...
Randy Read
"A redox switch in angiotensinogen modulates angiotensin release". Nature. 468 (7320): 108-11. Bibcode:2010Natur.468..108Z. doi: ...
Renin inhibitor
... s bind to the active site of renin and inhibit the binding of renin to angiotensinogen, which is the rate- ... Renin is a circulating enzyme that acts on a circulating peptide, angiotensinogen. Renin cleaves the peptide at the Leu10-Val11 ... Renin is highly selective for its only naturally occurring substrate which is angiotensinogen, and the incidence of unwanted ... The first generation of renin inhibitors, such as H-142, were peptide analogues of angiotensinogen. However, these inhibitors ...
Pierre Corvol
Role of angiotensinogen. Cell 71 : 169-180, 1992. Rousseau A., Michaud A., Chauvet M-T., Lenfant M. and Corvol P. The ... Role of angiotensinogen". Cell. 71 (1): 169-80. doi:10.1016/0092-8674(92)90275-H. PMID 1394429. S2CID 12142319. Dive, V.; ...
Renin-angiotensin system
Outside the liver, angiotensinogen is picked up from the circulation or expressed locally in some tissues; with renin they form ... Plasma renin then carries out the conversion of angiotensinogen, released by the liver, to a decapeptide called angiotensin I. ... Renin cleaves a decapeptide from angiotensinogen, a globular protein. The decapeptide is known as angiotensin I. Angiotensin I ...
Losartan
Renin then acts by converting angiotensinogen to angiotensin I; angiotensin converting enzyme (ACE) converts angiotensin I to ...
Blood pressure
Renin converts angiotensinogen (inactive form) to angiotensin I (active form). Angiotensin I flows in the bloodstream until it ... Renin converts angiotensinogen to angiotensin I, which is converted by angiotensin converting enzyme to angiotensin II. ...
Renal tissue kallikrein
"Kinetic studies of rat renin and tonin on purified rat angiotensinogen". Canadian Journal of Biochemistry and Cell Biology. 62 ...
Pathophysiology of hypertension
February 1999). "Angiotensinogen gene polymorphisms M235T/T174M: no excess transmission to hypertensive Chinese". Hypertension ... It performs this function by breaking down (hydrolysing) angiotensinogen, secreted from the liver, into the peptide angiotensin ... angiotensinogen and epithelial sodium channel". Hypertension. 33 (6): 1324-31. doi:10.1161/01.hyp.33.6.1324. PMID 10373210. ...
Shaodong Guo
"Novel Mechanism of Blood Pressure Regulation By Foxo1-Mediated Transcriptional Control of Hepatic Angiotensinogen". ...
RREB1
2005). "Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene". Int. J. Mol. Med. 13 ...
Osteopontin
Ricardo SD, Franzoni DF, Roesener CD, Crisman JM, Diamond JR (May 2000). "Angiotensinogen and AT(1) antisense inhibition of ...
Aortic regurgitation
Renin, a proteolytic enzyme, cleaves angiotensinogen to angiotensin I, which is converted to angiotensin II. In the case of ...
Serge Carrière
"Effect of Renin-Angiotensin System Blockade on the Expression of the Angiotensinogen Gene and Induction of Hypertrophy in Rat ... "Effect of renin-angiotensin system blockade on the expression of the angiotensinogen gene and induction of hypertrophy in rat ... "RAS blockade decreases blood pressure and proteinuria in transgenic mice over-expressing rat angiotensinogen gene in the kidney ... "Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells". ...
Endothiapepsin
... endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142". Biochemical Society Transactions. 13 (6): ...
Aliskiren
It cleaves angiotensinogen to angiotensin I, which is in turn converted by angiotensin-converting enzyme (ACE) to angiotensin ... Binding to this pocket prevents the conversion of angiotensinogen to angiotensin I. Aliskiren is also available as combination ...
Penbutolol
Under normal physiological conditions, the enzyme renin converts angiotensinogen to angiotensin I, which will then be converted ...
Fosinopril
Renin converts the inactive angiotensinogen into angiotensin I, which is converted to angiotensin II (AII) by angiotensin ...
Forasartan
"Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNA expression by high-frequency preganglionic ...
Renal artery stenosis
Juxtaglomerular cells secrete renin, which converts angiotensinogen to angiotensin I, which is then converted to angiotensin II ...
Renin receptor
Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I. This protein is associated with ...
Homeostasis
... from a plasma α-2-globulin called angiotensinogen. This decapeptide is known as angiotensin I. It has no known biological ...
Major basic protein
1995). "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic ... angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helmintho- ...
Subfornical organ
... participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical ...
Nephron
It produces and secretes into the circulation the enzyme renin (angiotensinogenase), which cleaves angiotensinogen and results ...
Bis(2-ethylhexyl) phthalate
Also, DEHP caused down regulation of several growth factors, such as angiotensinogen, transforming growth factor-beta, vascular ...
Assessing the efficacy and safety of angiotensinogen inhibition using human genetics | medRxiv
Lu H, Wu C, Howatt DA, et al. Angiotensinogen Exerts Effects Independent of Angiotensin II. Arterioscler Thromb Vasc Biol 2016 ... Wu C-H, Wang Y, Ma M, et al. Antisense oligonucleotides targeting angiotensinogen: insights from animal studies. Biosci Rep ... Assessing the efficacy and safety of angiotensinogen inhibition using human genetics. View ORCID ProfileJonas Bovijn, View ... Targeting angiotensinogen with RNA-based therapeutics. Curr Opin Nephrol Hypertens 2020; 29: 180-9. ...
Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model
MedlinePlus: Genes
Effects of angiotensinogen and angiotensin II type I receptor genes on blood pressure and left ventricular mass trajectories in...
Wang X, Zhu H, Dong Y, Treiber FA, Snieder H. Effects of angiotensinogen and angiotensin II type I receptor genes on blood ... Wang, X., Zhu, H., Dong, Y., Treiber, F. A., & Snieder, H. (2006). Effects of angiotensinogen and angiotensin II type I ... Wang, X, Zhu, H, Dong, Y, Treiber, FA & Snieder, H 2006, Effects of angiotensinogen and angiotensin II type I receptor genes ... Effects of angiotensinogen and angiotensin II type I receptor genes on blood pressure and left ventricular mass trajectories in ...
Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population | BMC...
Angiotensinogen (AGT) constitutes a central component of the renin-angiotensin system that controls the systemic blood pressure ... Table 3 The relationship of the angiotensinogen variants with coronary artery disease adjusted for the presence of its risk ... From: Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population ... The table displays the significant relationship of the angiotensinogen gene variants with coronary artery disease in presence ...
Abstracts from the 1st Annual Conference on Genetics and Public Health | CDC
Angiotensin - wikidoc
Angiotensinogen. Angiotensinogen is an α-2-globulin produced constitutively and released into the circulation mainly by the ... Human angiotensinogen is 452 amino acids long, but other species have angiotensinogen of varying sizes. The first 12 amino ... Plasma angiotensinogen levels are increased by plasma corticosteroid, estrogen, thyroid hormone, and angiotensin II levels. ... Angiotensin I (CAS# 11128-99-7), also called proangiotensin, is formed by the action of renin on angiotensinogen. Renin cleaves ...
Circadian rhythm of the intrarenal renin-angiotensin system is caused by glomerular filtration of liver-derived angiotensinogen...
Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers in COVID-19 - The Centre for Evidence-Based...
Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention...
We assessed the association between MARCD and sequence alterations in the promoter region of the angiotensinogen (AGT) gene. ... Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention ... Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention ... We assessed the association between MARCD and sequence alterations in the promoter region of the angiotensinogen (AGT) gene. ...
Augmented Urinary Excretion of Angiotensinogen Precedes Albuminuria in Human Young Adults with Overweight and Mice with High...
Gonzalez, A. A., Rivera, P., Miranda, C., Reverte, V., & Prieto, M. C. (2022). Augmented Urinary Excretion of Angiotensinogen ... Gonzalez, AA, Rivera, P, Miranda, C, Reverte, V & Prieto, MC 2022, Augmented Urinary Excretion of Angiotensinogen Precedes ... Augmented Urinary Excretion of Angiotensinogen Precedes Albuminuria in Human Young Adults with Overweight and Mice with High ... Dive into the research topics of Augmented Urinary Excretion of Angiotensinogen Precedes Albuminuria in Human Young Adults ...
Cellular localization of angiotensin type 1 receptor and angiotensinogen mRNAs in the subfornical organ of the rat brain - MDC...
Hypertension Clinical Presentation: History, Physical Examination, Hypertension and Cerebrovascular Disease
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Gene expression responses in male fathead minnows exposed to binary mixtures of an estrogen and antiestrogen | BMC Genomics |...
For example, angiotensinogen (AGT) is highly prominent in the example shown (Figure 6A) and serves as a node for the " ... Wong MK, Ge W, Woo NY: Positive feedback of hepatic angiotensinogen expression in silver sea bream (Sparus sarba). Mol Cell ... Estrogen action on hepatic synthesis of angiotensinogen and IGF-I: direct and indirect estrogen effects. J Steroid Biochem Mol ...
PRG2 proteoglycan 2, pro eosinophil major basic protein [Homo sapiens (human)] - Gene - NCBI
During pregnancy, the proform of eosinophil major basic protein-angiotensinogen constitutes the major form in late pregnancy. ... Title: Formation of high-molecular-weight angiotensinogen during pregnancy is a result of competing redox reactions with the ... angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and ...
RCSB PDB - 2V16: Crystal Structure of Renin with Inhibitor 3
MMRRC:042031-MU
DailyMed - MEDROXYPROGESTERONE ACETATE tablet
JCI -
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ
SMART: SERPIN domain annotation
Crystal structure of mouse angiotensinogen in the reduced form. 2wxz. Crystal structure of rat angiotensinogen in C2 space ... Crystal structure of rat angiotensinogen in P321 space group. 2x0b. Crystal structure of human angiotensinogen complexed with ... Angiotensinogen (P01019) (SMART). OMIM:106150: {Hypertension, essential, susceptibility to} ; {Preeclampsia, susceptibility to} ... Crystal structure of mouse angiotensinogen in the oxidised form. 2wxy. ...
Advanced ChemTech - Pancreatic Polypeptide (rana temporaria)
Angiotensin I | Harvard Catalyst Profiles | Harvard Catalyst
High Blood Pressure - Heart and Blood Vessel Disorders - Merck Manuals Consumer Version
Complete Publications | Max Planck Institute for Human Cognitive and Brain Sciences
AngiotensinPrecursorRenin substrateSynthesisSubstrateGenesExcretionHypertensiveMRNALiverIntrarenalProteinClinicalBloodHumanResultsGenePrecursorMouse AngiotensinogenPolymorphismDexamethasone regulate angiotensinogenSubstrateHypertensionAGTR1Acts on angiotensinogenEnzymeRenin-angiotensinogenUrinary angiotensinogenProreninVasoconstrictionAngiotensin receptorRenalELISAKidneyExpressionDetectionOccursTypeLevels
Angiotensin9
- The objective of this study was to evaluate the impact of variations of the angiotensinogen (AGT) and angiotensin II type I receptor (AGTR1) genes on progression of blood pressure (BP) and left ventricular mass (LVM) in multiethnic youth. (elsevier.com)
- Circadian rhythm of the intrarenal renin-angiotensin system is caused by glomerular filtration of liver-derived angiotensinogen depending on glomerular capillary pressure in adriamycin nephropathy rats. (bvsalud.org)
- Plasma angiotensinogen levels are increased by plasma corticosteroid , estrogen , thyroid hormone , and angiotensin II levels. (wikidoc.org)
- Angiotensin I ( CAS # 11128-99-7), also called proangiotensin , is formed by the action of renin on angiotensinogen . (wikidoc.org)
- Angiotensinogen is converted to angiotensin I by renin. (cebm.net)
- Renin catalytically cleaves these circulating angiotensinogen and forms angiotensin I. Angiotensin-converting enzymes then convert angiotensin I to its physiologically active form, angiotensin II. (news-medical.net)
- It catalyses the first step in the conversion of angiotensinogen to the hormone angiotensin II. (rcsb.org)
- Angiotensinogen is made by the liver and forms angiotensin I in the blood. (infectiousdiseaseadvisor.com)
- Polymorphisms in the Delta-aminolevulinic acid dehydratase (ALAD), hemochromatosis (HFE), heme oxygenase-1 (HMOX1), vitamin D receptor (VDR), glutathione S-transferase (GST) supergene family (GSTP1, GSTT1, GSTM1), apolipoprotein E (APOE),angiotensin II receptor-1 (AGTR1) and angiotensinogen (AGT) genes, are believed to alter toxicokinetics and/ or toxicodynamics of lead. (cdc.gov)
Precursor4
- It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver . (wikidoc.org)
- A decapeptide that is cleaved from precursor angiotensinogen by RENIN. (harvard.edu)
- El angiotensinógeno es el precursor inactivo de las ANGIOTENSINAS, que se generan en el organismo mediante escisiones enzimáticas sucesivas. (bvsalud.org)
- Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. (bvsalud.org)
Renin substrate1
- Angiotensinogen is also known as renin substrate. (wikidoc.org)
Synthesis2
- For this study, we compared a novel Gen 2 antisense oligonucleotide (ASO) that inhibits angiotensinogen (Agt) synthesis to lisinopril in adult conditional Pkd1 systemic-knockout mice, a model of ADPKD. (uab.edu)
- ALN-AGT, an RNA interference therapeutic targeting hepatic angiotensinogen synthesis in hypertensive patients, is designed to be administered two times a year by sub-cutaneous injection - a more favourable treatment method for patients than daily tablets. (richmondpharmacology.com)
Substrate1
- Angiotensinogen, synthesized in the liver, is the main substrate for renin. (news-medical.net)
Genes1
- Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes. (mpg.de)
Excretion1
- In addition, activation of intrarenal and intratubular RAS has been associated with increased pressure (BP), CKD, and augmentation of urinary excretion of angiotensinogen (uAGT) during T2D. (pucv.cl)
Hypertensive1
- They are hypertensive, and expression of the angiotensinogen gene is increased in their subcutaneous adipose tissues. (jci.org)
MRNA1
- The phytosterol diet increased renal angiotensinogen mRNA levels of these rats. (biomedcentral.com)
Liver2
- In renal damage with an impaired glomerular filtration barrier , liver -derived angiotensinogen (AGT) filtered through damaged glomeruli regulates intrarenal RAS activity. (bvsalud.org)
- Angiotensinogen is an α-2-globulin produced constitutively and released into the circulation mainly by the liver. (wikidoc.org)
Intrarenal1
- The expression of intrarenal renin, angiotensinogen (AGT), Ang II, Ang IIreceptor was examined by immunohistochemistry staining (IHCS). (alliedacademies.org)
Protein1
- High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. (nih.gov)
Clinical1
- Background Novel angiotensinogen (AGT) inhibitors are in early clinical development for treatment of hypertension. (medrxiv.org)
Blood1
- The phase 1 trial conducted at Richmond Pharmacology demonstrated favourable results with reductions in circulating angiotensinogen and blood pressure after six months. (richmondpharmacology.com)
Human1
- Human angiotensinogen is 452 amino acids long, but other species have angiotensinogen of varying sizes. (wikidoc.org)
Results1
- Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention Study. (ox.ac.uk)
Gene15
- To investigate the relationship between angiotensinogen (AGT) gene M235T polymorphism and hypertrophic cardiomyopathy (HCM) to explore the potential role of the AGT polymorphism in HCM. (nih.gov)
- To demonstrate a causative role for the local tissue angiotensin (ANG) system in lung fibrosis, we hypothesize that overexpression of the angiotensinogen (AGT) gene or pharmacologic elevation of lung tissue ANG II levels might cause apoptosis of AECs and lung fibrosis. (nih.gov)
- Acetyl Angiotensinogen (1-14),porcine, The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. (adooq.com)
- 2. Computational analyses prioritize and reveal the deleterious nsSNPs in human angiotensinogen gene. (nih.gov)
- From NCBI Gene: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. (nih.gov)
- X. Jeunemaitre (INSERM U36, College de France, Paris, France) provided new evidence indicating that several polymorphisms located in the 5' region and in the first intron of the angiotensinogen gene may contribute to the variability of plasma angiotensinogen levels. (drsharma.ca)
- OBJECTIVE: To investigate whether the M235T polymorphism of the angiotensinogen (AGT) gene and the insertion/deletion (I/D) polymorphism of the angiotensin-1 converting enzyme (ACE) gene predict blood pressure response to different antihypertensive agents. (ox.ac.uk)
- Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes. (cdc.gov)
- Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population. (cdc.gov)
- Represses the angiotensinogen gene. (nih.gov)
- Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy. (cdc.gov)
- Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure. (springer.com)
- Research in mice strains with useful copies from the angiotensinogen gene recommend a link between plasma angiotensinogen amounts and BP. (gp120inhibitors.com)
- We determined the association of angiotensin-converting enzyme (I/D, G2350A), angiotensinogen (M235T, T174M and A-6G) and renin (Bg/I and Mbo/I) gene polymorphisms with essential hypertension and the relationship between genetic variant of interest and high blood pressure response to ACE inhibitor (enalapril, lisinopril) in patients with essential hypertension subjects from Seremban, Malaysia. (essaycreek.com)
- Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human renin gene develop the PE syndrome, whereas those of the opposite cross do not. (mdc-berlin.de)
Precursor8
- Angiotensinogen is the inactive precursor of natural angiotensins. (uchicago.edu)
- Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. (ibl-japan.co.jp)
- Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. (nih.gov)
- RESULTS: Human islets expressed mRNAs for both the angiotensin precursor, angiotensinogen, and for angiotensin-converting enzyme. (ox.ac.uk)
- Furthermore, an AngII signaling blockage reversed the tumor immunosuppressive microenvironment, and inhibition of angiotensinogen (AGT, a precursor of AngII) expression strongly triggered an immune-activating cytokine profile in hypoxic mouse cancer cells. (biomedcentral.com)
- The classical RAS consists of several components: hepatic-derived precursor angiotensinogen (AGT), renally synthesized renin, pulmonary-bound angiotensin-converting enzyme (ACE), and the physiologically active peptide angiotensin II (AngII). (biomedcentral.com)
- 1. ( MeSH ) A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. (leparisien.fr)
- Produced from the precursor molecule, angiotensinogen (AGT), via an enzyme cascade involving ACE enzyme, angiotensin II exerts numerous effects on the homeostatic regulation of blood pressure, the vast majority of which are mediated via the angiotensin II type 1 receptor (AT1R) [6]. (essaycreek.com)
Mouse Angiotensinogen3
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiotensinogen (AGT) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (elisastrip.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Angiotensinogen (AGT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (elisastrip.com)
- Description: Quantitativesandwich ELISA kit for measuring Mouse angiotensinogen (aGT) in samples from serum, plasma, cell culture supernates, tissue homogenates. (elisastrip.com)
Polymorphism1
- C angiotensinogen polymorphism. (cdc.gov)
Dexamethasone regulate angiotensinogen3
- Talk to your doctor become pregnant while angiotensin II and dexamethasone regulate angiotensinogen mRNA by different mechanisms. (lecafeshop.co.uk)
- Detrimental to the psyche sterol regulatory lK, Hauss-Wegrzyniak Centrino Labs Sustanon dexamethasone regulate angiotensinogen Hd Labs Super Cut Mix 300 mRNA by different mechanisms. (offbeatguides.com)
- Angiotensin II and dexamethasone regulate angiotensinogen mRNA by different mechanisms. (phldnc.com)
Substrate3
- DABCYL-GABA-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS (also called Renin Substrate I in some literature) contains a renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen. (mobitec.com)
- Cleavage of the substrate occurs specifically at the Leu-Val bond and corresponds to the renin cleavage site of angiotensinogen. (mobitec.com)
- Renin cleaves angiotensinogen(renin substrate) to form angiotensin I. ACE then cleaves angiotensin I to angiotensin II. (healthdrugpdf.com)
Hypertension7
- Background Novel angiotensinogen (AGT) inhibitors are in early clinical development for treatment of hypertension. (ox.ac.uk)
- Among the studies urinary excretion of angiotensinogen in a rat model of angiotensin II (AII)-dependent hypertension has been reported to be a marker of the activity of the local intrarenal renin-angiotensin system. (ibl-japan.co.jp)
- Intrarenal AII increases to an extent in AII-dependent hypertension that cannot be explained by the plasma AII equilibration alone, and two mechanisms, an increase in intracellular uptake of AII and an increase in intrarenal expression of angiotensinogen, have been proposed to explain it. (ibl-japan.co.jp)
- The crucial role of renin in controlling blood pressure via the angiotensinogen cleavage and consequently its role in hypertension and congestive heart failure urged a broad research concerning this enzyme. (taylorfrancis.com)
- Untreated transgenic rats overexpressing the human renin and angiotensinogen genes (dTGR) feature hypertension and severe left ventricular hypertrophy with focal areas of necrosis, and die at age 7 weeks. (unboundmedicine.com)
- Preliminary data demonstrates effects of co-planar and noncoplanar PCBs to increase the expression of adipocyte differentiation factors (PPAR gamma) and adipokines involved in obesity-related hypertension (angiotensinogen). (nih.gov)
- Estimation of risk and interaction of single nucleotide polymorphisms at angiotensinogen locus causing susceptibility to essential hypertension: a case control study. (cdc.gov)
AGTR12
- Polymorphisms in the Delta-aminolevulinic acid dehydratase (ALAD), hemochromatosis (HFE), heme oxygenase-1 (HMOX1), vitamin D receptor (VDR), glutathione S-transferase (GST) supergene family (GSTP1, GSTT1, GSTM1), apolipoprotein E (APOE),angiotensin II receptor-1 (AGTR1) and angiotensinogen (AGT) genes, are believed to alter toxicokinetics and/or toxicodynamics of lead. (cdc.gov)
- Five of the miRNA mimics (miR-181a-5p (predicted to target: renin (REN), angiotensin converting enzyme (ACE)), miR-378 (REN, ACE), miR-663 (REN), miR-483-3p (ACE, ACE2, angiotensinogen (AGT), angiotensin II type 1 receptor (AGTR1)) and miR-514 (AGT)) were associated with a dose-dependent reduction in cell proliferation. (edu.au)
Acts on angiotensinogen2
- Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I . Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II , an extremely powerful vasoconstrictor. (bvsalud.org)
- Renin acts on angiotensinogen, which is made in the liver and converts it to angiotensin I . Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II. (cuny.edu)
Enzyme5
- The cleavage of angiotensinogen yields angiotensin I which is further processed by angiotensin converting enzyme to angiotensin II. (taylorfrancis.com)
- The renin enzyme circulates in the blood stream and breaks down ( hydrolyzes ) angiotensinogen secreted from the liver into the peptide angiotensin I . (leparisien.fr)
- The drug inhibits angiotensin converting enzyme (ACE) while preventing the release of angiotensinogen (ANP). (ifex3000.is)
- Polymorphisms of angiotensinogen and angiotensin-converting enzyme associated with lower extremity arterial disease in the Health, Aging and Body Composition study. (springer.com)
- In the traditional look at, synthesis of Ang II starts with the transformation of angiotensinogen into Ang I from the enzyme renin. (schwitzbiotech.com)
Renin-angiotensinogen2
- Incubation of h(P)RR (but not control) cells with prorenin + angiotensinogen yielded more angiotensin than expected on the basis of the activity of soluble prorenin, whereas angiotensin generation during incubation of both cell types with renin + angiotensinogen was entirely due to soluble renin. (eur.nl)
- The renin + angiotensinogen-induced vasoconstriction of isolated iliac arteries from control and transgenic rats was also due to soluble renin only. (eur.nl)
Urinary angiotensinogen4
- The objective of this study was to evaluate the prognostic value of urinary angiotensinogen, a candidate prognostic AKI biomarker identified in post-cardiac surgery patients, in this heterogeneous population. (biomedcentral.com)
- Urinary angiotensinogen was measured by ELISA and corrected for urine creatinine in 45 patients who developed AKI in the ICU. (biomedcentral.com)
- Elevated urinary angiotensinogen is associated with adverse events in AKI patients in the ICU. (biomedcentral.com)
- Urinary angiotensinogen and risk of severe AKI. (uams.edu)
Prorenin1
- PRR-dependent activation of prorenin catalyzes the conversion of angiotensinogen (AGT) to angiotensin-I (Ang-I), which is a key process in the RAS cascade [ 5 ]. (biomedcentral.com)
Vasoconstriction1
- Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. (antibodies-online.com)
Angiotensin receptor1
- So we performed a series of experiments, in which we isolated preadipocytes from human adipose tissue and exposed them to angiotensinogen (AGT), Ang II, or angiotensin receptor antagonists in the differentiation medium. (drsharma.ca)
Renal3
- 0.05), klotho reduced renal angiotensin II levels (202 ± 8 vs 126 ± 4 fmol/g.kidney.wt) associated with reduced renal expression of angiotensinogen. (lww.com)
- In the urine, we also measured angiotensinogen along with other biomarkers of renal dysfunction. (biomedcentral.com)
- Angiotensinogen modulates renal vasculature growth. (hopefulsolutionsinc.org)
ELISA1
- Description: A sandwich quantitative ELISA assay kit for detection of Human Angiotensinogen (AGT) in samples from serum, plasma, urine, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (elisastrip.com)
Kidney1
- 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway. (uchicago.edu)
Expression1
- Baseline angiotensinogen expression was higher in SHR cells, and CT-1 induced a 1.7-fold and 3.2-fold increase of angiotensinogen mRNA in cardiomyocytes from Wistar rats and SHR respectively. (cun.es)
Detection1
- Moreover, the detection of angiotensinogen- and renin-mRNA in these cultures suggested an endogenous production of Ang II. (jneurosci.org)
Occurs1
- The peak in reduction of circulating angiotensinogen occurs after approximately 3 weeks. (medscape.com)
Type1
- Assuming that the angiotensinogen formed by mature adipocytes may perhaps directly affect preadipocyte differentiation, we performed co-culture experiments, where we were able to show that mature adipocytes were indeed able to inhibit preadipocyte differentiation, an effect that was almost entirely abolished by blockade of the Ang II type 1 receptor. (drsharma.ca)
Levels1
- Typically, the higher a person's angiotensinogen levels are, the. (testmaxprep.com)