Angiotensin Amide: The octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Amides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)Receptor, Angiotensin, Type 1: An angiotensin receptor subtype that is expressed at high levels in a variety of adult tissues including the CARDIOVASCULAR SYSTEM, the KIDNEY, the ENDOCRINE SYSTEM and the NERVOUS SYSTEM. Activation of the type 1 angiotensin receptor causes VASOCONSTRICTION and sodium retention.Receptors, Angiotensin: Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells.Receptor, Angiotensin, Type 2: An angiotensin receptor subtype that is expressed at high levels in fetal tissues. Many effects of the angiotensin type 2 receptor such as VASODILATION and sodium loss are the opposite of that of the ANGIOTENSIN TYPE 1 RECEPTOR.Angiotensin I: A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.Angiotensin Receptor Antagonists: Agents that antagonize ANGIOTENSIN RECEPTORS. Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR.Angiotensin II Type 1 Receptor Blockers: Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.Angiotensin III: A heptapeptide formed from ANGIOTENSIN II after the removal of an amino acid at the N-terminal by AMINOPEPTIDASE A. Angiotensin III has the same efficacy as ANGIOTENSIN II in promoting ALDOSTERONE secretion and modifying renal blood flow, but less vasopressor activity (about 40%).Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.Tetrazoles
Immunologic production of antiangiotensin. I. Preparation of angiotensin-protein complex antigen. (1/13)Angiotensin II was coupled with bovine gamma-globulin (BGG) through the following series of reactions. See PDF for Structure By determinations of the aromatic amine and tyrosine contents of p-aminobenzoylangiotensin II, the number of p-aminobenzoyl residues introduced per molecule of angiotensin II was calculated. Absorption spectra (between 250 and 500 mmicro) of BGG complexes of p-aminobenzoylangiotensin II and six different para substituted aromatic amines were compared. Specific activities (dog units/millimicromole) of the different intermediate products were determined. Presence of a terminal, free amino group does not appear to be an absolute requirement for the biological activity of angiotensin II, since substitution of a p-aminobenzoyl radical in this group yields a product with 40 to 50 per cent of the activity of the parent compound. Angiotensin I, on the other hand, is completely inactivated under identical circumstances. Possible implication of this finding has been discussed. (+info)
Immunologic production of antiangiotensin. II. Production and detection of antiangiotensin. (2/13)The parenteral administration of benzoylangiotensin II-azo-BGG to rabbits produced an antiserum with antiangiotensin activity. Antiangiotensin inhibited the biological action of p-aminobenzoylangiotensin II, valine(5)-angiotensin II (free acid form), isoleucine(5)-angiotensin II and valine(5)-angiotensin II (amide form), but it was totally inert towards angiotensin 1. Antiangiotensin activity was distinguished from that of serum angiotensinase by the following observations: (a) an angiotensinase-free gamma-globulin fraction contained antiangiotensin, (b) angiotensinase inactivated angiotensin II (both the amide and free acid forms) and angiotensin I in contrast to the remarkable specificity for angiotensin II exhibited by antiangiotensin. Serological demonstration of antiangiotensin included: (a) a comparison of its precipitin reaction with the angiotensin BGG complex with the reaction with BGG alone, (b) the partial inhibition of the precipitin reaction with the angiotensin BGG complex by angiotensin II, (c) a precipitin reaction with a different angiotensin II protein complex (cat serum). Angiotensin II administered parenterally as the free polypeptide was not antigenic. (+info)
Some pharmacological actions of synthetic analogues of angiotensinamide. (3/13)In order to evaluate the importance of some structural features of asparagyl(1)-Valyl(5)-angiotensin II (angiotensinamide) for its pharmacological actions, the relative potencies of angiotensinamide and five peptide analogues were studied on the blood pressure of the rat, the isolated rat uterus and the isolated guinea-pig ileum. All the modifications of the angiotensinamide structure that were studied led to a decrease of potency which, however, was not the same on all three preparations. The importance of the guanido group, the phenolic group and the length of the peptide chain for the pharmacological activities of these peptides is discussed. (+info)
Actions of some peptides on bronchial muscle. (4/13)The decapeptide kallidin-10, substance P and angiotensin increased the resistance of guinea-pig lungs to inflation; lysine- or arginine-vasopressin and oxytocin were inactive. Acetylsalicylate antagonized this action of kallidin-10, as it does that of bradykinin, but it failed to antagonize substance P or angiotensin. Bradykinin also increased resistance to inflation of rabbit lungs and, to a lesser extent, rat lungs. It caused a relatively slow contraction of guinea-pig tracheal and bronchial muscle in vitro, but it did not contract isolated rabbit, dog or human bronchus. The relative potencies of different substances on different bronchial test preparations, and also in different species, were not parallel. (+info)
Pharmacological actions of pepsitensin. (5/13)In confirmation of the results of Croxatto and his co-workers, plasma proteins incubated with pepsin yielded a substance (pepsitensin) with pressor activity. Euglobulin gave a much higher yield than the other plasma protein fractions. Incubation for 4 hr at pH 4 gave high yields of pressor activity (pepsitensin) but no antidiuretic activity; incubation of euglobulin for 4 hr at pH 2.5 yielded extracts with antidiuretic as well as pressor activity. Incubation for 8 to 11 hr at pH 2.5 produced the highest yield of both activities. Further incubation, at the same pH, up to 20 hr caused a rapid decline in the pressor activity of the extracts, but the antidiuretic activity was much more resistant to destruction by pepsin. Pepsitensin was found to be very soluble in water and poorly soluble in organic solvents. It is not inactivated by thioglycollate. In blood pressure assays some animals did not respond to pepsitensin, and nephrectomized (17 to 24 hr) rats were found to be more suitable preparations. Pepsitensin was shown to exert pressor effect by direct action on the blood vessels. Its pressor action could be differentiated from that of tyramine, dimethylphenylpiperazine, nicotine, noradrenaline and Pitressin but not from that of angiotensin. The isolated guinea-pig ileum and the rat uterus were equally sensitive to angiotensin and pepsitensin. In paper chromatograms, in the solvent system butanol-acetic acid-water, the R(F) of pepsitensin was very similar to that of angiotensin. (+info)
Stimulation of intestinal nervous elements by angiotensin. (6/13)The stimulation of nervous elements in the intestine by the polypeptide angiotensin has been examined. Comparisons between nicotine, a neurotropic agent, acetylcholine which exerts principally a musculotropic action and angiotensin have been made by examining their interactions with hexamethonium and the anticholinesterase 1,5-di-(p-N-allyl-N-methylaminophenyl)pentan-3-one dibromide in both the rabbit and guinea-pig ileum. The effect of atropine on the responses of the guinea-pig ileum and botulinum toxin on the responses of the rabbit ileum to angiotensin was also tested. The results show that angiotensin causes most of its contractile response in both the guinea-pig and rabbit ileum by an indirect action, through the stimulation of nervous tissue. (+info)
Home blood pressure monitoring in diabetes. (7/13)Forty three children with diabetes were recruited to evaluate home blood pressure monitoring using an electronic oscillometric sphygmomanometer (Philips HP5330). This device was found to be simple to use and reliable. It fulfilled the accuracy criteria of the American Association for the Advancement of Medical Instrumentation for both systolic and diastolic blood pressure and those of the British Hypertension Society for systolic blood pressure. Thirty eight children successfully measured their own blood pressure at home and taught other family members to do the same. The results indicate that home blood pressure monitoring is of value in the management of diabetic children. (+info)
Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation. (8/13)(+info)
... (INN; BAN and USAN angiotensin amide) is a potent vasoconstrictor used as a cardiac stimulant. It is a ...
List of MeSH codes (D23)
... angiotensin i MeSH D23.469.050.050.050 --- angiotensin ii MeSH D23.469.050.050.050.050 --- angiotensin amide MeSH D23.469. ... angiotensin iii MeSH D23.469.050.175 --- eicosanoids MeSH D23.469.050.175.450 --- leukotrienes MeSH D23.469.050.175.450.400 ... 050.050.050.700 --- saralasin MeSH D23.469.050.050.050.725 --- 1-sarcosine-8-isoleucine angiotensin ii MeSH D23.469.050.050.075 ...
Discovery and development of ACE inhibitors
1982), "Angiotensin-Converting Enzyme Inhibitors: Importance of the Amide Carbonyl of Mercaptoacyl Amino Acids for Hydrogen ... It showed inhibitory effect of angiotensin I and bradykinin without having any effects on angiotensin II. Then researchers ... "Roles of the Two Active Sites of Somatic Angiotensin-Converting Enzyme in the Cleavage of Angiotensin I and Bradykinin: ... Angiotensin I is mainly hydrolyzed by the C-domain in vivo but bradykinin is hydrolyzed by both active sites. Thus, by ...
... (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug ... "The Procognitive and Synaptogenic Effects of Angiotensin IV-Derived Peptides Are Dependent on Activation of the Hepatocyte ... "Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle1-Angiotensin IV Analogs". The Journal ... "Evaluation of metabolically stabilized angiotensin IV analogs as pro-cognitive/anti-dementia agents". The Journal of ...
List of MeSH codes (D12.644)
... angiotensin i MeSH D12.644.456.073.041 --- angiotensin ii MeSH D12.644.456.073.041.050 --- angiotensin amide MeSH D12.644. ... angiotensin i MeSH D12.644.400.070.078 --- angiotensin ii MeSH D12.644.400.070.080 --- angiotensin iii MeSH D12.644.400.085 ... angiotensin iii MeSH D12.644.456.073.070 --- angiotensinogen MeSH D12.644.456.120 --- antipain MeSH D12.644.456.193 --- ... 456.073.041.800 --- saralasin MeSH D12.644.456.073.041.815 --- 1-sarcosine-8-isoleucine angiotensin ii MeSH D12.644.456.073.055 ...
Index of biochemistry articles
... angiotensin - angiotensin II - angiotensin receptor - ankyrin - annexin II - antibiotic - antibody - apoenzyme - apolipoprotein ... amide - amine - amino - amino acid - amino acid receptor - amino acid sequence - amino acid sequence homology - aminobutyric ...
Length: A polypeptide is a single linear chain of many amino acids, held together by amide bonds. A protein consists of one or ... An octapeptide has eight amino acids (e.g., angiotensin II). A nonapeptide has nine amino acids (e.g., oxytocin). A decapeptide ... amide) bonds. The covalent chemical bonds are formed when the carboxyl group of one amino acid reacts with the amino group of ... as a water molecule is released during formation of each amide bond. All peptides except cyclic peptides have an N-terminal and ...
This leads to the product angiotensin I (Ang I) which is a decapeptide. Ang I is broken down by the angiotensin-converting ... The amide group forms a hydrogen bond with a secondary amine group of Ser76. The S1 and S1′ pockets are occupied by the two ... Ferrario, C. M.; Iyer, S. N. (1998). "Angiotensin-(1-7): A bioactive fragment of the renin-angiotensin system". Regulatory ... design Angiotensin Angiotensin II receptor antagonist Beta blocker Circulatory system Discovery and development of angiotensin ...
It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide ... CES1 is responsible for the activation of many prodrugs such as angiotensin-converting enzyme (ACE) inhibitors, oseltamivir, ... These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing xenobiotics and drugs such as cocaine and ... focus on angiotensin-converting enzyme inhibitors". Drug Metab Dispos. 42 (1): 126-33. doi:10.1124/dmd.113.053512. PMID ...
List of enzymes
In linear amides) Urease (EC 184.108.40.206) Category:EC 3.5.2 (In cyclic amides) Beta-lactamase (EC 220.127.116.11) Category:EC 3.5.3 (In ... EC 3.4.15 Angiotensin converting enzyme Category:EC 3.4.21 Serine protease Chymotrypsin (EC 18.104.22.168) Trypsin (EC 22.214.171.124) ...
Angiotensin II stimulates AVP secretion, in keeping with its general pressor and pro-volumic effects on the body. Atrial ... with the cysteine residues forming a disulfide bond and the C-terminus of the sequence converted to a primary amide. Lysine ... Matsukawa T, Miyamoto T (March 2011). "Angiotensin II-stimulated secretion of arginine vasopressin is inhibited by atrial ... natriuretic peptide inhibits AVP secretion, in part by inhibiting Angiotensin II-induced stimulation of AVP secretion. Cortisol ...
"Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid ... "Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough". ...
Alpha-7 nicotinic receptor
2006). "Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic ... is prevented through angiotensin II activation of a tyrosine phosphatase". J. Pharmacol. Exp. Ther. 309 (1): 16-27. doi:10.1124 ... neutralized by angiotensin II AT(2) receptor activation Bradanicline - partial agonist, in development for treatment of ...
Selective glucocorticoid receptor modulator
Mapracorat is one of a number of trifluoropropanolamines and -amides which are less obviously steroid-like in structure. Other ... Examples of glucocorticoid-responsive genes include those that encode annexin A1, TSC22D3 (also known as GILZ), angiotensin- ...
Also within this conserved family is a C-terminus that has an amide added to it. This family which kisspeptin includes ... Lastly, the kisspeptin-angiotensin II pathway of producing aldosterone is increased. Aldosterone that comes from the ...
Nonsteroidal anti-inflammatory drug
Kidney failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin ... "A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase". J Am Chem Soc. 135 (1): 22-25. doi: ... At these elevated levels, angiotensin II also constricts the afferent arteriole into the glomerulus in addition to the efferent ... enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid amide hydrolase (FAAH). Most ...
The amide form of nicotinic acid, named nicotinamide, acts as a vitamin although neither activates the GPR109A nor exhibits the ... GPER also regulates components of the renin-angiotensin system, which also controls blood pressure, and is required for ...
List of EC numbers (EC 3)
... fatty acid amide hydrolase EC 126.96.36.199: (R)-amidase EC 188.8.131.52: L-proline amide hydrolase EC 184.108.40.206: 2-amino-5- ... angiotensin-converting enzyme 2 EC 220.127.116.11: cathepsin X EC 18.104.22.168: acylaminoacyl-peptidase EC 22.214.171.124: peptidyl- ...
Define pepsitensin: a vasoconstrictor pressor polypeptide similar to angiotensin formed by the action of pepsin on angiotensinogen
The Staining of Nervous Elements by the Bodian Method I. the Influence of Factors Preceding Impregnation | Journal of Cell...
The stainability of neural elements is determined during the various stages of tissue preparation which precede impregnation.. The hypothesis (Romanes, 1950) that variations in the physiological state of the neurones at the time of fixation might influence the stain was examined. Feeding and anaesthesia did not influence the staining of gastric nerve fibres under the conditions of the experiments.. A study was made of fixing fluids for Bodian staining. A picric-acetic-alcohol mixture and alcoholic Bouin were convenient and effective, each being superior to formaldehyde-acetic-alcohol. For overnight fixation formaldehyde solution neutralized with calcium carbonate was satisfactory, but where prolonged fixation is permissible formaldehyde neutralized with excess of magnesium carbonate gave superior results.. Attention was drawn to the probability that the final stain could be improved by pretreatment of mounted sections before silvering. Dewaxed sections were treated individually with 27 ...
Calcium Carbide Calcium Carbide is a chemical compound containing calcium and carbide, with a chemical formula of CaC2. Pure Calcium Carbide is colorless,
Read Accentures report about how to navigate historic regulatory change and the implications for mortgage lenders resulting from the TILA-RESPA Integrated Mortgage Disclosure Regulation.
Croxatto, H.R., Huidobro, F., Croxatto, R. et Salvestrini, H., Action cholinestérasique du sang veineux pendant lexcitation musculaire directe et indirecte, Compt. Rend. Seanc. Soc. Biol. Paris, 130, p. 326 (1939); Croxatto, H.R. and Croxatto, R., Pepsitensin - A hypertensin-like substance produced by peptidic digestion of proteins, Science, 95, p. 101 (1942); Croxatto, H.R., Rojas, G. and Barnafi, L., The liberation of antidi- uretic factor by the hypertensinogen pepsin reaction, Acta Physiol. Latinoamer., 2, p. 178 (1951); Croxatto, H.R., Pereda, T. and Mellada, R., Peptides with oxytocin and pressor activity obtained from acidified rat serum, Nature, 184, p. 1496 (1959); Croxatto, H.R. and Barnafi, L., Hormone and hormone-like activity of active polypeptides, Rec. Prog. Horm. Res., 16, p. 236 (1961); Croxatto, H.R. and Belmar, J., Hypertensive effects of bradykinin in rats, Nature, 192 (4805), p. 879 (1961); Croxatto, H.R., Pereda, T., Belmar, J. and Labarca, E., Polypeptides ...
Dear Sarah, Caffeine has a wide variety of effects. It stimulates your central nervous system, it acts as a diuretic, and it can help people with asthma breathe more easily by relaxing their bronchial muscles. However, after searching a variety of medical databases, I found no evidence that consuming caffeine can stunt your growth. If you have any questions or comments, please send me an email ...
Greenmedinfo.com - Natural Health Resource - The worlds most widely referenced, open access, natural medicine database, with 30,000+ study abstracts and growing daily
Greenmedinfo.com - Natural Health Resource - The worlds most widely referenced, open access, natural medicine database, with 30,000+ study abstracts and growing daily
Medical marijauna shop regulations raise questions - News - The Taunton Daily Gazette, Taunton, MA - Taunton, MA
Medical marijuana shops in Weymouth would have to be located 500 feet away from a school, day care, playground, park or any area where children gather under a new zoning amendment proposed by the planning board.
The examination of synthetic valyl-5-angiotensin II-amide in the conscious dog revealed the following:. 1. Both the arterial and the central venous pressure responses exhibit tachyplylaxis when high doses of angiotensin II are administered, althoug not when medium or low doses are given. Cross-tachyphylaxis can be demonstrated between renin and angiotensin II but not between either of these and norepinephrine. These results suggest that tachyphylaxis to renin is due to tachyphylaxis to angiotensin.. 2. Angiotensin II and norepinephrine provoke a dose-dependent increase in central venous pressure. The threshold dose is about 10 times higher than that necessary for the effect on arterial pressure. In doses eliciting the same increase of arterial blood pressure, norepinephrine is about twice as active on the venous pressure as angiotensin II.. 3. Anesthesia and atropinization both reduce or abolish the effect of angiotensin II as well as that of norepinephrine on the venous pressure, indicating the ...
1. The threshold pain stimulus was elevated in cats after doses of 3.0-15.0 mgm. per kilogram of body weight of 2-amino-6-methylheptane hydrochloride intraperitoneally.. 2. Local anesthesia was produced by tropical application of solutions of the hydrochloride or free base of 2-amino-6-methylheptane to rabbits eyes.. 3. Intravenously in dogs anesthetized with pentobarbital sodium, 2-amino-6-methylheptane hydrochloride exhibited 1/500-1/1000 the pressor activity of epinephrine.. 4. As determined with a Cushny Myocardiograph, 2-amino-6-methylheptane hydrochloride was found to cause an increase in cardiac rate and amplitude of contraction.. 5. Intravenously in dogs, anesthetized with pentobarbital sodium, doses of 0.5 to 1.0 mgm. per kilogram of body weight of 2-amino-6-methylheptane hydrochloride had no detectable effect on the small intestine, detrusor of the urinary bladder, urine secretion or respiration.. 6. In general, concentrations of 1:10,000 to 1:200,000 of 2-amino-6-methylheptane ...
β-Methylphenethylamine (β-Me-PEA, BMPEA), or 1-amino-2-phenylpropane, is an organic compound of the phenethylamine class, and a positional isomer of the drug amphetamine, with which it shares some properties. In particular, both amphetamine and β-methylphenethylamine are human TAAR1 agonists. In appearance, it is a colorless or yellowish liquid. Relatively little information has been published about this substance. Hartung and Munch reported that it had good antihypotensive (pressor) activity in experimental animals, and that it was orally active. The MLD (minimum lethal dose) for the HCl salt was given as 500 mg/kg (rat, s.c.) and 50 mg/kg (rabbit, i.v.). A study by Graham and co-workers at the Upjohn Co., comparing a large number of β-methylphenethylamines substituted on the benzene ring showed that β-methylphenethylamine itself had 1/700 x the pressor activity of epinephrine, corresponding to ~ 1/3 the potency of amphetamine. The β-methyl compound also had ~ 2 x the broncho-dilating ...
Expression and functional characterization of breast cancer-associated cytochrome P450 4Z1 in Saccharomyces cerevisiae | Drug...
Thank you for sharing this Drug Metabolism & Disposition article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
Natural decapeptide or synthetic octapeptide angiotonin was ineffective in lowering arterial pressure or decreasing the carotid occlusion response when injected into the carotid sinus adventitia. Injection of synthetic octapeptide angiotonin into the lumen of the carotid sinus after tying its branches decreased the carotid occlusion response but the effect depended on dosage many times the pressor activity of 1 γ of norepinephrine which elicited a comparable effect.. ...
A comparison of some pharmacological actions of prostaglandin E1, 6-oxo-PGE1and PGI2 | [email protected]
Adaikan, G P., Tai, M.Y., Lau, L.C. (1984). A comparison of some pharmacological actions of prostaglandin E1, 6-oxo-PGE1and PGI2. Prostaglandins 27 (4) : 505-516. [email protected] Repository. https://doi.org/10.1016/0090-6980(84)90086- ...
... Theo-24 Cr causes dilation of the bronchial tubes by relaxing bronchial muscle. It is effective against chronic obstructive pulmonary diseases such as asthma, pulmonary emphysema, and bronchitis.
Let us now take a look at some of the studies that have convinced both scientists and doctors alike that Forskolin has therapeutic benefits and can treat asthma symptoms in patients:. According to a study published in 2003 conducted by Martin Hum DHD, Ph. D examining the causes of asthma and how dietary therapy can help, mentions Forskolin as one of the most effective herbal remedies for treating asthma. He stated based on numerous clinical trials that he had studied and observed. In this report, he states that a small double blind trial showed that when Forskolin powder was inhaled by patients with asthma, it helped lower lung spasms in comparison to placebo. (2). In a report published in Volume 11 of Alternative Medicine Review 2006 highlighted the study by Bauer K. and Sertl K,that showed the benefits of Forskolin for treating asthma. The report stated that aerosolized dry powder of Forskolin helped provide relax the bronchial muscles and also alleviated asthma symptoms. It further supported ...
British Library EThOS: Characterisation of the pharmacological actions of three novel de-orphanised receptors and the...
Characterisation of the pharmacological actions of three novel de-orphanised receptors and the natriuretic peptide receptor-A ...
London, Sep 14 (IANS) Researchers have extracted an active pharmaceutical substance from the leaves of a common ornamental plant - coralberry - which could provide hope for people with asthma. The findings, led by researchers at the University of Bonn in Germany and asthma specialists from the UK, showed that the leaves of the coralberry contain a substance with the cryptic name "FR900359".. The extracts when used in mice almost inhibited the characteristic contraction of the airways. Further, the study found that "FR900359" is very effective at preventing the bronchial muscles from contracting. Asthmatics regularly suffer from these pronounced contractions preventing adequate ventilation of the lungs. The resulting shortness of breath can be life-threatening.. The compound in the coralberry leaves relieves these spasms and is supposedly more effective and has a more prolonged action than the most common asthma drug salbutamol, the researchers noted in the paper published in the journal Science ...
1. The early work of Hunt and Taveau (1911) on the pharmacological action of acetyl-β-methyl choline has been confirmed with other preparations of this compound.. 2. The statements that the preparations used in our early work were impure have again been shown to be erroneous.. 3. Further experiments on the relation of atropine to the action of acetyl-β-methyl choline are described.. 4. The blood pressure lowering bodies which have been found in the adrenals are briefly considered.. ...
Glycine Agents: Substances used for their pharmacological actions on glycinergic systems. Glycinergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.
Calcitonin Gene-Related Peptide Is a Depressor in NG-Nitro-l-Arginine Methyl Ester-Induced Hypertension During Pregnancy |...
In a previous study, we demonstrated that administration of CGRP can reverse the hypertension induced by L-NAME during pregnancy but not during the postpartum period. The results of the present study provide evidence that endogenous CGRP is also playing a hemodynamic role in this model of experimental preeclampsia. The CGRP8-37-induced increase of the already elevated MAP in the L-NAME-treated rats on days 19 to 21 of pregnancy indicates that in this setting, CGRP is acting as a compensatory vasodilator in an attempt to buffer the elevated BP. Interestingly, the pressor effect of the CGRP antagonist was attenuated on postpartum day 1, which is consistent with what we observed in our earlier studies using exogenously administered CGRP.. In light of the rapid onset of the hypertensive effect of CGRP8-37 in the L-NAME-treated pregnant rats, and because the antagonist probably does not penetrate the central nervous system, it is likely that the pressor activity of CGRP8-37 seen in these experiments ...
Upper side: impressed with AX in an equilateral hexagon. Pharmacological action, proviron balances a deficiency of androgen formation which begins to fall gradually with increasing age. Proviron has had a Upper side: impressed with AX in an equilateral hexagon. Pharmacological action, proviron balances a deficiency of androgen formation which begins to fall gradually with increasing age. Proviron has had a lifetime of esterification experience. These effects result in a decrease in water buildup in the body, which gives the muscles a leaner, harder look. Nella oligospermia consigliabile una posologia di 50-75 mg di Proviron 50 mg 20 cpr (1-1 compressa) al d per la durata di un ciclo spermiogenetico (circa 90 giorni). Producing esters has become second nature. Indicaes de Proviron diminuio da capacidade fisica e mental em paciente de meia-idade ou idade avanada: distrbios resultantes de deficincia andrognica, tais como, reduo de eficincia, fatigabilidade maior, diminuio da capacidade de ...
1. Competitive or non-competitive inhibition of the myotropic and pressor response of angiotensin II is dependent on the nature of the substituent in position 8 of the antagonist peptide analogue. Substituents in other positions of the molecule, particularly position 1, contribute greatly to the potency of these antagonists.. 2. As is evidenced after adrenalectomy or after blockade with phentolamine and phenoxybenzamine, the initial pressor activity observed with all the antagonistic peptides is partially due to the release of catecholamines and partially to a direct myotropic effect.. 3. [Sar1, Thr8]angiotensin II has been found to possess the lowest agonist to antagonist ratio of all antagonists tested.. 4. [Des-Asp1, Ile8]angiotensin II selectively and specifically inhibits the release of aldosterone from adrenal cortex. Thus, unlike angiotensin II, this heptapeptide has pronounced organ specificity, suggesting that the heptapeptide (angiotensin III) is the aldosterone-releasing ...
Home Blood Pressure Monitoring (HBPM) and Pharmaceutical care have been proposed to improve therapeutic compliance and to guide treatment decisions, but their effects on BP control are still under debate.. This is a factorial randomized controlled trial including adult hypertensive patients under drug treatment but with office BP and 24h ABPM uncontrolled. Participants will be allocated to one of four groups: HBPM; HBPM and Pharmaceutical care; Pharmaceutical care; or control. All participants will receive usual care for high blood pressure. Participants will be followed for 60 days. ...
We endeavour to identify the structural determinants of peptide analogues and their cognate GPCRs involved in LiSS which will assist in the development of signal-selective ligands/drugs, directed at different clinical endpoints with improved therapeutic outcomes and reduced side-effects. When activated, GPCRs can also interact with different G proteins or other GPCR-interacting proteins (GIPs) at the intracellular side to mediate different pharmacological actions. We have shown that binding of different peptides to the same receptor can stabilise different receptor shapes that preferentially activate different pharmacological actions which we termed "ligand-induced selective signalling". G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface signalling proteins which are characterised by the architecture of 7-transmembrane domains. GPCRs play a pivotal role in mediating signal transduction of endogenous ligands, such as neurotransmitters and hormones, from the ...
Adults need ongoing blood pressure assessment through their lives because 1 in 4 Canadians is affected by hypertension (high blood pressure) and 50% of 50 year-old adults are hypertensive.
Some Contributions to the Pharmacology of Synthetic Angiotensin | Circulation
The examination of synthetic valyl-5-angiotensin II-amide in the conscious dog revealed the following:. 1. Both the arterial ... 2. Angiotensin II and norepinephrine provoke a dose-dependent increase in central venous pressure. The threshold dose is about ... 3. Anesthesia and atropinization both reduce or abolish the effect of angiotensin II as well as that of norepinephrine on the ... 5. During hemorrhagic hypotension, the response to angiotensin II may be retained or even enhanced and is less likely to have ...http://circ.ahajournals.org/content/25/1/193
Angiotensin III Depressor Action in the Conscious Rabbit Is Blocked by Losartan but not PD 123319 | Hypertension
The half-lives of angiotensin II, angiotensin II-amide, angiotensin III, Sar1-Ala8-angiotensin II and renin in the circulatory ... Effects of des-Asp-angiotensin I on the contractile action of angiotensin II and angiotensin III. Eur J Pharmacol. 1995;278:175 ... Angiotensin-(1-7) did not exert a depressor action, and the reduced potency of angiotensin IV (relative to angiotensin III) was ... Comparative effects of angiotensin II and its degradation products angiotensin III and angiotensin IV in rat aorta. Br J ...http://hyper.ahajournals.org/content/35/1/130
Angiotensin amide | Define Angiotensin amide at Dictionary.com
Angiotensin amide definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ... A peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory ...https://www.dictionary.com/browse/angiotensin-amide
Angiotensinamide - Wikipedia
Angiotensinamide (INN; BAN and USAN angiotensin amide) is a potent vasoconstrictor used as a cardiac stimulant. It is a ...https://en.wikipedia.org/wiki/Angiotensinamide
The effect of ACTH, renin, angiotensin II, and various precursors on biosynthesis of aldosterone by adrenal slices.<...
The effect of ACTH, renin, angiotensin II, and various precursors on biosynthesis of aldosterone by adrenal slices. The Journal ... Kaplan, N. M., & BARTER, F. C. (1962). The effect of ACTH, renin, angiotensin II, and various precursors on biosynthesis of ... Kaplan, Norman M ; BARTER, F. C. / The effect of ACTH, renin, angiotensin II, and various precursors on biosynthesis of ... The effect of ACTH, renin, angiotensin II, and various precursors on biosynthesis of aldosterone by adrenal slices. / Kaplan, ...https://utsouthwestern.pure.elsevier.com/en/publications/the-effect-of-acth-renin-angiotensin-ii-and-various-precursors-on
Search Articles | University of Toronto Libraries
Angiotensin Amide - metabolism , Animals , Biological Ontologies , Humans , Angiotensin Amide - genetics , Databases, Genetic ... angiotensin amide - genetics (1) 1 Filter by. Remove filter. angiotensin amide - metabolism (1) 1 ...https://query.library.utoronto.ca/index.php/search/q?kw=Author:Laulederkind,%20S.J.F
Angiostrophy | Define Angiostrophy at Dictionary.com
angiotensin. *angiotensin amide. *angiotensin i. *angiotensin ii. Browse the Dictionary. :*#. *A. *B ...https://www.dictionary.com/browse/angiostrophy
... angiotensin I,angiotensin II,angiotensin converting enzyme,angiotensinase,Amide,Angiotensin Amide,5-Valine-angiotensin II amide ... angiotensin II aspartic-beta-amide 5-valine,1-asparagine-5-valine-angiotensin II,val5-angiotensin II-asp1-beta-amide, ... 5-Valine-angiotensin II amide; angiotensin II aspartic-b-amide 5-valine; 1-asparagine-5-valine-angiotensin II; val5-angiotensin ... angiotensin II, by the splitting off of the C-terminal His-Leu residues by the angiotensin converting enzyme (ACE) or ...http://www.druglead.com/cds/angiotensin.html
Amino-acid sequence in a hypertensin. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.https://www.ncbi.nlm.nih.gov/pubmed/13321895?dopt=Abstract
NAVER Academic > Search...
Val5-angiotensin II-Asp1-amide... Selected option. 3 view options * Springer * MEDLINE®/PubMed® ... Inactivation of angiotensin II by rat kidney homogenates. 1971 J. Jelínek et al. Naunyn-Schmiedebergs Archives of Pharmacology ... The angiotensin-inactivating capacity of homogenates prepared from kidneys of rats subjected to various experimental procedures ...https://academic.naver.com/search.naver?field=3&query=Naunyn-Schmiedeberg%27s+Archives+of+Pharmacology+268%EA%B6%8C+4%ED%98%B8
Angiotensin-converting enzyme | definition of angiotensin-converting enzyme by Medical dictionary
What is angiotensin-converting enzyme? Meaning of angiotensin-converting enzyme medical term. What does angiotensin-converting ... Looking for online definition of angiotensin-converting enzyme in the Medical Dictionary? angiotensin-converting enzyme ... angiotensin. *angiotensin amide. *angiotensin II. *angiotensin-converting enzyme inhibitor. *angiotensin-converting enzyme ... angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme, which converts angiotensin I ...https://medical-dictionary.thefreedictionary.com/angiotensin-converting+enzyme
Angiotensin receptors | definition of angiotensin receptors by Medical dictionary
What is angiotensin receptors? Meaning of angiotensin receptors medical term. What does angiotensin receptors mean? ... Looking for online definition of angiotensin receptors in the Medical Dictionary? angiotensin receptors explanation free. ... angiotensin II receptor antagonist. *angiotensin II receptor blocker. *angiotensin III. *angiotensin III amide ... Angiotensin-converting enzyme inhibition Post REvascularization Study. *Angiotensin-converting enzyme inhibition Post ...https://medical-dictionary.thefreedictionary.com/angiotensin+receptors
JCI - Volume 55, Issue 4
Similarly, infusion of angiotensin II amide led to a significantly increased ipsilateral excretion rate of prostaglandin E2 and ... In man, i.v. infusion of angiotensin also led to an increased urinary eliminiation of prostaglandin E. These results show that ... These studies indicate that there is a close correlation of bradykinin levels with renin activity and angiotensin II, in both ... The possibility that bradykinin, a potent vasodilator, might be a physiological antagonist of the renin-angiotensin system was ...https://www.jci.org/55/4
MICRO-RNAS OF THE MIR-15 FAMILY MODULATE CARDIOMYOCYTE SURVIVAL AND CARDIAC REPAIR - Patent application
Non-limiting examples of a vasopressor, also known as an antihypotensive, include amezinium methyl sulfate, angiotensin amide, ... angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists, Non-limiting examples of angiotensin ... conversion of the relatively inactive angiotensin I to the active angiotensin II in the rennin-angiotensin system. In addition ... Non limiting examples of an angiotensin II receptor blocker, also known as an angiotensin II receptor antagonist, an ANG ...http://www.patentsencyclopedia.com/app/20140051745
Neuropeptide Y (18-36) is a competitive antagonist of neuropeptide Y in rat cardiac ventricular membranes. - Semantic Scholar
... a hexatriacontapeptide amide, is present in high concentrations in the mammalian heart. Specific receptors of NPY in rat ... Neuropeptide Y (NPY), a hexatriacontapeptide amide, is present in high concentrations in the mammalian heart. Specific ...https://www.semanticscholar.org/paper/Neuropeptide-Y-%2818-36%29-is-a-competitive-antagonist-Balasubramaniam-Sheriff/5a9f4f99d75db48ecc35e0d31db40f8bd6c2d76a
Arterial Angiotensin II and Venous Immunoreactive Material before and during Angiotensin Infusion in Man | Clinical Science |...
... with angiotensin II amide the A:V ratio was 1·72 ± 0·49 (n = 35), and with synthetic human angiotensin it was 1·63 ± 0·2 (n = 6 ... similar results being obtained with angiotensin II amide and synthetic human angiotensin II. ... Arterial Angiotensin II and Venous Immunoreactive Material before and during Angiotensin Infusion in Man W. Oelkers W. Oelkers ... Characterization of Immunoreactive Angiotensin in Canine Cerebrospinal Fluid as Des-Asp 1 -Angiotensin II Clin Sci Mol Med ( ...https://portlandpress.com/clinsci/article/43/2/209/69520/Arterial-Angiotensin-II-and-Venous-Immunoreactive
Anodic Oxidation | The Moeller Research Group
Anodic Amide Oxidations: A Total Synthesis of the Angiotensin-Converting Enzyme Inhibitor A58365A. Kevin D. Moeller and Poh Lee ... The methoxylated amides were cyclized to form tricyclic amides using titanium tetrachloride. ... An anodic amide oxidation based procedure for annulating lactam rings onto amino acid derivatives has been used to construct ... Anodic amide oxidations in the presence of electron-rich phenyl rings: evidence for an intramolecular electron-transfer ...https://pages.wustl.edu/moellergroup/research/publications-type/amino-acidpeptide?page=5
Another key challenge requires special attention in improvin
The world stands on the edge of an historic public health success with the imminent eradication of dracunculiasis (guinea-worm disease) and polio. Since the World Health Assembly called for the eradication of dracunculiasis in 1986 and poliomyelitis in 1988, astonishing progress has been made. In 2016, only 25 human cases of dracunculiasis were reported from three countries, transmission of wild poliovirus was found in only three countries, and 37 cases of polio were reported worldwide. In addition to these achievements, there has been progress in the elimination of the little-known disease podoconiosis (endemic non-filarial elephantiasis). Essential to Alu-equivalent family elimination effort is the need to understand the geography of the disease to identify potentially at-risk areas and set a benchmark for evaluating elimination efforts. The global burden of podoconiosis is not at present clearly defined, although available estimates suggest that globally there are 4 million people with ...http://angiotensin-1-2-1-8-amide.com/index.php?g=Wap&m=Article&a=detail&id=16
Direct inhibition of renin as a cardiovascular pharmacotherapy: focus on aliskiren.
The important role of renin-angiotensin-aldosterone system blockade in the treatment of systemic hypertension, heart failure, ... Amides / adverse effects, chemistry, pharmacokinetics, pharmacology, therapeutic use*. Angiotensin II / blood, physiology. ... 0/Amides; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Fumarates; 0/ ... Given the established beneficial effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the ...http://www.biomedsearch.com/nih/Direct-inhibition-renin-as-cardiovascular/17700383.html
Patent US7419504 - Poly(ester amide) block copolymers - Google Patents
... ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the ... Examples of such cytostatic substance include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. ... A. Poly(ester amide) Block (A). Poly(ester amide), as used herein, encompasses any polymer having both ester and amide groups ... Novel poly(ester-amide) hot-melt adhesives. US4656242. 7 Jun 1985. 7 Apr 1987. Henkel Corporation. Poly(ester-amide) ...http://www.google.com.au/patents/US7419504
Angiotensin-converting enzyme (ACE) | Article about angiotensin-converting enzyme (ACE) by The Free Dictionary
Also known as hypertensin Explanation of angiotensin-converting enzyme (ACE) ... Find out information about angiotensin-converting enzyme (ACE). A decapeptide hormone that influences blood vessel constriction ... angiotensin III. *angiotensin III amide. *angiotensin IV. *angiotensin precursor. *Angiotensin receptor. *Angiotensin Receptor ... angiotensin. (redirected from angiotensin-converting enzyme (ACE)). Also found in: Dictionary, Thesaurus, Medical. angiotensin ...https://encyclopedia2.thefreedictionary.com/angiotensin-converting+enzyme+
US5312828A - Substituted imidazoles having angiotensin II receptor blocking activity - Google Patents
... and methods of using these compounds to produce angiotensin II receptor antagonism in mammals. ... Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the ... N-aroylamino acid amides as endothelin inhibitors US6090828A (en) 2000-07-18. 5-aryleheteroarylalkyl-1,3,5-trisubstituted-1,2,4 ... Angiotensin II receptor blocking benzimidazoles US5399566A (en) 1995-03-21. Pyridine derivatives having angiotensin II ...https://patents.google.com/patent/US5312828A/en
Poly(ester amide) block copolymers - Patent # 7699889 - PatentGenius
Examples of such cytostatic substance include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. ... A. Poly(Ester Amide) Block (A). Poly(ester amide), as used herein, encompasses any polymer having both ester and amide groups ... Poly(Ester Amide) Block Copolymer. In one aspect of the present invention, provided herein is a copolymer that includes a soft ... Synthesis and Study of Regular Poly(ester amide)s Based on Bis(.alpha./amino acid).alpha.,.omega./Alkylene Diesters, and ...http://www.patentgenius.com/patent/7699889.html
The novel amide linked Angiotensin II cyclic analogues y,e- cyclo 3, 5 - Sar1-Glu3-Lys5 ANG II 1 and y, e - cyclo 3, 5 - Sar- ... The rational design and practical preparation of unsymmetrical polyamine carbamates and amides, based on steroid templates of ... the knowledge that the amide (-NHCO-) group in modified steroidal derivatives of Chlorambucil enhances the... ...https://www.centrallakesclinic.biz/chemical-shifts/
US20130129794A1 - Poly(Ester Amide)-Based Drug Delivery Systems - Google Patents
Implantable medical devices including a coating having a bioactive agent and a poly(ester amide) polymer. Methods of forming ... Examples of cytostatic substances include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. Capoten ... Unsaturated poly(ester-amide) biomaterials US20050271700A1 (en) 2004-06-03. 2005-12-08. Desnoyer Jessica R. Poly(ester amide) ... Poly(ester-amide) and poly(amide) coatings for implantable medical devices for controlled release of a protein or peptide and a ...https://patents.google.com/patent/US20130129794A1/en
- The effect of ACTH, renin, angiotensin II, and various precursors on biosynthesis of aldosterone by adrenal slices. (elsevier.com)
- Cross-tachyphylaxis can be demonstrated between renin and angiotensin II but not between either of these and norepinephrine. (ahajournals.org)
- These results suggest that tachyphylaxis to renin is due to tachyphylaxis to angiotensin. (ahajournals.org)
- The enzymatic action of renin acts on angiotensinogen to form the decapeptide angiotensin I, which is relatively inactive. (thefreedictionary.com)
- ACE inhibitors, such as captopril , are antagonists of the renin-angiotensin-aldosterone system and potentiators of the kinin system and are used for treatment of hypertension, usually in conjunction with a diuretic. (thefreedictionary.com)
- See Renin/angiotensin/aldosterone system. (thefreedictionary.com)
- The chapters provide insights gained by the genetic manipulation of angiotensin II, assessment of its transcriptional and translational regulation, work on the angiotensin receptors , the status of the specific molecular components of the renin-angiotensin-aldosterone system under differing conditions, and functional responses to the angiotensins. (thefreedictionary.com)
- Response of the kallikrein-kinin and renin-angiotensin systems to saline infusion and upright posture. (jci.org)
- The important role of renin-angiotensin-aldosterone system blockade in the treatment of systemic hypertension, heart failure, diabetic kidney disease, and atherogenesis has been clearly established. (biomedsearch.com)
- The theoretical therapeutic advantages for inhibiting the detrimental effects of the renin-angiotensin system at its most upstream point have served as the impetus for the development of renin inhibitors. (biomedsearch.com)
- The advent of aliskiren, the first in a novel class of orally active, nonpeptide, highly specific, human renin inhibitors, provides a new modality in the armamentarium of renin-angiotensin system antagonists. (biomedsearch.com)
- Studies in marmosets and rats demonstrated that aliskiren reduced blood pressure in a dose-dependent manner and is highly efficacious in blocking plasma renin activity with parallel reductions in the levels of the other downstream constituents of the renin-angiotensin system. (biomedsearch.com)
- It in turn is acted upon by peptidases (converting enzymes), chiefly in the lungs, to form the octapeptide angiotensin II, a powerful vasopressor and a stimulator of aldosterone secretion by the adrenal cortex. (thefreedictionary.com)
- Angiotensin II is hydrolyzed in various tissues to form heptapeptide angiotensin III, which has less vasopressor activity but more effect on the adrenal cortex. (thefreedictionary.com)
- The substance so formed is a decapeptide called angiotensin I which is converted to the active pressor agent, angiotensin II , by the splitting off of the C- terminal His-Leu residues by the angiotensin converting enzyme (ACE) or angiotensinase . (druglead.com)
- angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme , which converts angiotensin I to angiotensin II and inactivates bradykinin. (thefreedictionary.com)
- Peptidyl-dipeptidase A is the name recommended by the IUBMB for this enzyme (EC 126.96.36.199), though it is more popularly known as angiotensin I-converting enzyme (ACE). (thefreedictionary.com)
- The (ACE) enzyme that converts angiotensin I to the active form angiotensin II. (thefreedictionary.com)
- An anodic amide oxidation based procedure for annulating lactam rings onto amino acid derivatives has been used to construct the angiotensin-converting enzyme inhibitor A58365A. (wustl.edu)
- Given the established beneficial effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the treatment of cardiovascular and renovascular diseases, future studies may further elucidate a similar protective role for aliskiren both as a monotherapy and as part of a combination therapy. (biomedsearch.com)
- 1. Angiotensin II together with any immunoreactive fragments of angiotensin were measured in arterial and venous plasma before and during infusion of angiotensin II amide in five normotensive subjects, both in sodium-replete and sodium-depleted states. (portlandpress.com)
- 5. Results of an in vitro study suggest that the formation of new angiotensin in the vein is not sufficient to explain the lower A:V ratio of PAC before infusion. (portlandpress.com)
- 6. It is proposed that arterial PAC rather than venous IM should be measured when the relationship between blood levels and biological effects of the peptide are the object of the study, particularly during angiotensin infusion or when rapid changes in circulating angiotensin occur. (portlandpress.com)
- 1. Both the arterial and the central venous pressure responses exhibit tachyplylaxis when high doses of angiotensin II are administered, althoug not when medium or low doses are given. (ahajournals.org)
- In doses eliciting the same increase of arterial blood pressure, norepinephrine is about twice as active on the venous pressure as angiotensin II. (ahajournals.org)
- 2. Angiotensin II and norepinephrine provoke a dose-dependent increase in central venous pressure. (ahajournals.org)
- 3. Anesthesia and atropinization both reduce or abolish the effect of angiotensin II as well as that of norepinephrine on the venous pressure, indicating the reflex nature of the underlying mechanism. (ahajournals.org)
- Because the antibody used in the radioimmunoassay cross-reacted with larger angiotensin breakdown products and because these fragments are present in higher concentrations in venous than arterial plasma, samples of both were assayed. (portlandpress.com)