Angiotensin Amide
Angiotensin II
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Amides
Receptor, Angiotensin, Type 1
Receptors, Angiotensin
Receptor, Angiotensin, Type 2
Angiotensin I
Angiotensin Receptor Antagonists
Angiotensin II Type 1 Receptor Blockers
Angiotensin III
Losartan
Immunologic production of antiangiotensin. I. Preparation of angiotensin-protein complex antigen. (1/13)
Angiotensin II was coupled with bovine gamma-globulin (BGG) through the following series of reactions. See PDF for Structure By determinations of the aromatic amine and tyrosine contents of p-aminobenzoylangiotensin II, the number of p-aminobenzoyl residues introduced per molecule of angiotensin II was calculated. Absorption spectra (between 250 and 500 mmicro) of BGG complexes of p-aminobenzoylangiotensin II and six different para substituted aromatic amines were compared. Specific activities (dog units/millimicromole) of the different intermediate products were determined. Presence of a terminal, free amino group does not appear to be an absolute requirement for the biological activity of angiotensin II, since substitution of a p-aminobenzoyl radical in this group yields a product with 40 to 50 per cent of the activity of the parent compound. Angiotensin I, on the other hand, is completely inactivated under identical circumstances. Possible implication of this finding has been discussed. (+info)Immunologic production of antiangiotensin. II. Production and detection of antiangiotensin. (2/13)
The parenteral administration of benzoylangiotensin II-azo-BGG to rabbits produced an antiserum with antiangiotensin activity. Antiangiotensin inhibited the biological action of p-aminobenzoylangiotensin II, valine(5)-angiotensin II (free acid form), isoleucine(5)-angiotensin II and valine(5)-angiotensin II (amide form), but it was totally inert towards angiotensin 1. Antiangiotensin activity was distinguished from that of serum angiotensinase by the following observations: (a) an angiotensinase-free gamma-globulin fraction contained antiangiotensin, (b) angiotensinase inactivated angiotensin II (both the amide and free acid forms) and angiotensin I in contrast to the remarkable specificity for angiotensin II exhibited by antiangiotensin. Serological demonstration of antiangiotensin included: (a) a comparison of its precipitin reaction with the angiotensin BGG complex with the reaction with BGG alone, (b) the partial inhibition of the precipitin reaction with the angiotensin BGG complex by angiotensin II, (c) a precipitin reaction with a different angiotensin II protein complex (cat serum). Angiotensin II administered parenterally as the free polypeptide was not antigenic. (+info)Some pharmacological actions of synthetic analogues of angiotensinamide. (3/13)
In order to evaluate the importance of some structural features of asparagyl(1)-Valyl(5)-angiotensin II (angiotensinamide) for its pharmacological actions, the relative potencies of angiotensinamide and five peptide analogues were studied on the blood pressure of the rat, the isolated rat uterus and the isolated guinea-pig ileum. All the modifications of the angiotensinamide structure that were studied led to a decrease of potency which, however, was not the same on all three preparations. The importance of the guanido group, the phenolic group and the length of the peptide chain for the pharmacological activities of these peptides is discussed. (+info)Actions of some peptides on bronchial muscle. (4/13)
The decapeptide kallidin-10, substance P and angiotensin increased the resistance of guinea-pig lungs to inflation; lysine- or arginine-vasopressin and oxytocin were inactive. Acetylsalicylate antagonized this action of kallidin-10, as it does that of bradykinin, but it failed to antagonize substance P or angiotensin. Bradykinin also increased resistance to inflation of rabbit lungs and, to a lesser extent, rat lungs. It caused a relatively slow contraction of guinea-pig tracheal and bronchial muscle in vitro, but it did not contract isolated rabbit, dog or human bronchus. The relative potencies of different substances on different bronchial test preparations, and also in different species, were not parallel. (+info)Pharmacological actions of pepsitensin. (5/13)
In confirmation of the results of Croxatto and his co-workers, plasma proteins incubated with pepsin yielded a substance (pepsitensin) with pressor activity. Euglobulin gave a much higher yield than the other plasma protein fractions. Incubation for 4 hr at pH 4 gave high yields of pressor activity (pepsitensin) but no antidiuretic activity; incubation of euglobulin for 4 hr at pH 2.5 yielded extracts with antidiuretic as well as pressor activity. Incubation for 8 to 11 hr at pH 2.5 produced the highest yield of both activities. Further incubation, at the same pH, up to 20 hr caused a rapid decline in the pressor activity of the extracts, but the antidiuretic activity was much more resistant to destruction by pepsin. Pepsitensin was found to be very soluble in water and poorly soluble in organic solvents. It is not inactivated by thioglycollate. In blood pressure assays some animals did not respond to pepsitensin, and nephrectomized (17 to 24 hr) rats were found to be more suitable preparations. Pepsitensin was shown to exert pressor effect by direct action on the blood vessels. Its pressor action could be differentiated from that of tyramine, dimethylphenylpiperazine, nicotine, noradrenaline and Pitressin but not from that of angiotensin. The isolated guinea-pig ileum and the rat uterus were equally sensitive to angiotensin and pepsitensin. In paper chromatograms, in the solvent system butanol-acetic acid-water, the R(F) of pepsitensin was very similar to that of angiotensin. (+info)Stimulation of intestinal nervous elements by angiotensin. (6/13)
The stimulation of nervous elements in the intestine by the polypeptide angiotensin has been examined. Comparisons between nicotine, a neurotropic agent, acetylcholine which exerts principally a musculotropic action and angiotensin have been made by examining their interactions with hexamethonium and the anticholinesterase 1,5-di-(p-N-allyl-N-methylaminophenyl)pentan-3-one dibromide in both the rabbit and guinea-pig ileum. The effect of atropine on the responses of the guinea-pig ileum and botulinum toxin on the responses of the rabbit ileum to angiotensin was also tested. The results show that angiotensin causes most of its contractile response in both the guinea-pig and rabbit ileum by an indirect action, through the stimulation of nervous tissue. (+info)Home blood pressure monitoring in diabetes. (7/13)
Forty three children with diabetes were recruited to evaluate home blood pressure monitoring using an electronic oscillometric sphygmomanometer (Philips HP5330). This device was found to be simple to use and reliable. It fulfilled the accuracy criteria of the American Association for the Advancement of Medical Instrumentation for both systolic and diastolic blood pressure and those of the British Hypertension Society for systolic blood pressure. Thirty eight children successfully measured their own blood pressure at home and taught other family members to do the same. The results indicate that home blood pressure monitoring is of value in the management of diabetic children. (+info)Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation. (8/13)
(+info)
Angiotensinamide
... (INN; BAN and USAN angiotensin amide) is a potent vasoconstrictor used as a cardiac stimulant. It is a ... Angiotensin "Angiotensinamide". Index nominum, international drug directory = internationales Arzneistoff-und ...
List of MeSH codes (D23)
... angiotensin i MeSH D23.469.050.050.050 - angiotensin ii MeSH D23.469.050.050.050.050 - angiotensin amide MeSH D23.469.050.050. ... angiotensin iii MeSH D23.469.050.175 - eicosanoids MeSH D23.469.050.175.450 - leukotrienes MeSH D23.469.050.175.450.400 - ... 050.700 - saralasin MeSH D23.469.050.050.050.725 - 1-sarcosine-8-isoleucine angiotensin ii MeSH D23.469.050.050.075 - ...
Discovery and development of ACE inhibitors
1982), "Angiotensin-Converting Enzyme Inhibitors: Importance of the Amide Carbonyl of Mercaptoacyl Amino Acids for Hydrogen ... It showed inhibitory effect of angiotensin I and bradykinin without having any effects on angiotensin II. Then researchers ... "Roles of the Two Active Sites of Somatic Angiotensin-Converting Enzyme in the Cleavage of Angiotensin I and Bradykinin: ... Angiotensin I is mainly hydrolyzed by the C-domain in vivo but bradykinin is hydrolyzed by both active sites. Thus, by ...
Dihexa
... (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug ... "The Procognitive and Synaptogenic Effects of Angiotensin IV-Derived Peptides Are Dependent on Activation of the Hepatocyte ... "Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle1-Angiotensin IV Analogs". The Journal ... "Evaluation of metabolically stabilized angiotensin IV analogs as pro-cognitive/anti-dementia agents". The Journal of ...
List of MeSH codes (D12.644)
... angiotensin i MeSH D12.644.456.073.041 - angiotensin ii MeSH D12.644.456.073.041.050 - angiotensin amide MeSH D12.644.456.073. ... angiotensin i MeSH D12.644.400.070.078 - angiotensin ii MeSH D12.644.400.070.080 - angiotensin iii MeSH D12.644.400.085 - ... angiotensin iii MeSH D12.644.456.073.070 - angiotensinogen MeSH D12.644.456.120 - antipain MeSH D12.644.456.193 - bradykinin ... 041.800 - saralasin MeSH D12.644.456.073.041.815 - 1-sarcosine-8-isoleucine angiotensin ii MeSH D12.644.456.073.055 - ...
Index of biochemistry articles
... angiotensin - angiotensin II - angiotensin receptor - ankyrin - annexin II - antibiotic - antibody - apoenzyme - apolipoprotein ... amide - amine - amino - amino acid - amino acid receptor - amino acid sequence - amino acid sequence homology - aminobutyric ...
Pimobendan
... cyclization of the resulting ortho amino amide by means of a strong acid leads to the formation of the corresponding ... These drugs inhibit the action of angiotensin-converting enzyme, producing a balanced vasodilation, along with other ...
Carboxylesterase 1
It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide ... CES1 is responsible for the activation of many prodrugs such as angiotensin-converting enzyme (ACE) inhibitors, oseltamivir, ... These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing xenobiotics and drugs such as cocaine and ... focus on angiotensin-converting enzyme inhibitors". Drug Metab Dispos. 42 (1): 126-33. doi:10.1124/dmd.113.053512. PMID ...
Peptide
e.g., angiotensin IV). A heptapeptide has seven amino acids. (e.g., spinorphin). An octapeptide has eight amino acids (e.g., ... A water molecule is released during formation of each amide bond. All peptides except cyclic peptides have an N-terminal (amine ... held together by amide bonds. A protein consists of one or more polypeptides (more than about 50 amino acids long). An ... angiotensin II). A nonapeptide has nine amino acids (e.g., oxytocin). A decapeptide has ten amino acids (e.g., gonadotropin- ...
Renin inhibitor
This leads to the product angiotensin I (Ang I) which is a decapeptide. Ang I is broken down by the angiotensin-converting ... The amide group forms a hydrogen bond with a secondary amine group of Ser76. The S1 and S1′ pockets are occupied by the two ... Ferrario, C. M.; Iyer, S. N. (1998). "angiotensin-(1-7): A bioactive fragment of the renin-angiotensin system". Regulatory ... design Angiotensin Angiotensin II receptor antagonist Beta blocker Circulatory system Discovery and development of angiotensin ...
List of enzymes
In linear amides) Urease (EC 3.5.1.5) Category:EC 3.5.2 (In cyclic amides) Beta-lactamase (EC 3.5.2.6) Category:EC 3.5.3 (In ... EC 3.4.15 Angiotensin converting enzyme Category:EC 3.4.21 Serine protease Chymotrypsin (EC 3.4.21.1) Trypsin (EC 3.4.21.4) ...
Vasopressin
Angiotensin II stimulates AVP secretion, in keeping with its general pressor and pro-volumic effects on the body. Atrial ... with the cysteine residues forming a disulfide bond and the C-terminus of the sequence converted to a primary amide. Lysine ... Matsukawa T, Miyamoto T (March 2011). "Angiotensin II-stimulated secretion of arginine vasopressin is inhibited by atrial ... natriuretic peptide inhibits AVP secretion, in part by inhibiting Angiotensin II-induced stimulation of AVP secretion. Cortisol ...
Carboxypeptidase A
... and the target enzyme of Captopril, angiotensin-converting enzyme, have very similar structures, as they ... Salt linkage with positively charged Arg-145 Hydrogen bond from Tyr-248 Hydrogen bond from the nitrogen of the Asn-144 amide ... Recent biomedical research on collagenase, enkephlinase, and angiotensin-converting enzyme used carboxypeptidase A for ... lower blood pressure through the renin-angiotensin-aldosterone system. Carboxypeptidase A (CPA) contains a zinc (Zn2+) metal ...
TRPV1
2014-08-01). "Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute ... January 2011). "Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors- ... Leishman E, Bradshaw HB (2015-01-01). "Chapter 3 - N-Acyl Amides: Ubiquitous Endogenous Cannabimimetic Lipids That Are in the ... September 2005). "Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent ...
Alpha-7 nicotinic receptor
December 2006). "Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 ... is prevented through angiotensin II activation of a tyrosine phosphatase". The Journal of Pharmacology and Experimental ... neutralized by angiotensin II AT(2) receptor activation Bradanicline - partial agonist, in development for treatment of ...
Ritonavir
The diamine is then treated sequentially with two thiazole derivatives, each linked by an amide bond, to provide ritonavir. ... protein to the human angiotensin-converting enzyme-2 (hACE2) receptor, which is critical for the virus entry into human cells ...
Selective glucocorticoid receptor modulator
Mapracorat is one of a number of trifluoropropanolamines and -amides which are less obviously steroid-like in structure. Other ... Examples of glucocorticoid-responsive genes include those that encode annexin A1, TSC22D3 (also known as GILZ), angiotensin- ...
SRT-3025
SRT-1460 SRT-1720 SRT-2104 SRT-2183 STAC-9 Li Y, Shen G, Yu C, Li G, Shen J, Gong J, Xu Y (December 2014). "Angiotensin II ... Amides). ...
Kisspeptin
Also within this conserved family is a C-terminus that has an amide added to it. This family which kisspeptin includes ... Lastly, the kisspeptin-angiotensin II pathway of producing aldosterone is increased. Aldosterone that comes from the ...
Cinnamycin
Beside this ammonium-binding site, the backbone amide hydrogens of residues 10−13 are also critical in binding the lipid ... In addition to the antimicrobial properties, cinnamycin-like peptides exhibit inhibitory actions against the angiotensin- ...
Nonsteroidal anti-inflammatory drug
Kidney failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin ... January 2013). "A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase". Journal of the American ... At these elevated levels, angiotensin II also constricts the afferent arteriole into the glomerulus in addition to the efferent ... enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid amide hydrolase (FAAH). ...
GPER
The amide form of nicotinic acid, named nicotinamide, acts as a vitamin although neither activates the GPR109A nor exhibits the ... GPER also regulates components of the renin-angiotensin system, which also controls blood pressure, and is required for ...
List of EC numbers (EC 3)
... fatty acid amide hydrolase EC 3.5.1.100: (R)-amidase EC 3.5.1.101: L-proline amide hydrolase EC 3.5.1.102: 2-amino-5- ... angiotensin-converting enzyme 2 EC 3.4.17.24: tubulin-glutamate carboxypeptidase * *No Wikipedia article EC 3.4.18.1: cathepsin ... fatty acid amide hydrolase EC 3.5.1.100: (R)-amidase EC 3.5.1.101: L-proline amide hydrolase EC 3.5.1.102: 2-amino-5- ... angiotensin-converting enzyme 2 EC 3.4.17.24: tubulin-glutamate carboxypeptidase * *No Wikipedia article EC 3.4.18.1: cathepsin ...
Serotonin
Zeiss DR, Piater LA, Dubery IA (2021). "Hydroxycinnamate Amides: Intriguing Conjugates of Plant Protective Metabolites". Trends ... angiotensin II, norepinephrine). The vasoconstrictive property is mostly seen in pathologic states affecting the endothelium - ...
Sex differences in brain aging and predictors of neurodegeneration in cognitively healthy older adults - PubMed
Refining genome-wide associated loci for serum uric acid in individuals with African ancestry - PubMed
MeSH Browser
Angiotensins [D12.644.456.073] * Angiotensin II [D12.644.456.073.041] * Angiotensin Amide [D12.644.456.073.041.050] ... Angiotensins [D23.469.050.050] * Angiotensin II [D23.469.050.050.050] * Angiotensin Amide [D23.469.050.050.050.050] ... The octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction.. Terms. Angiotensin Amide ... 1-Asparagine-5-valine Angiotensin II 5-Valine-Angiotensin II Amide Angiotensinamide Hypertensin Pharm Action. Vasoconstrictor ...
MeSH Browser
Angiotensins [D12.644.456.073] * Angiotensin II [D12.644.456.073.041] * Angiotensin Amide [D12.644.456.073.041.050] ... Angiotensins [D23.469.050.050] * Angiotensin II [D23.469.050.050.050] * Angiotensin Amide [D23.469.050.050.050.050] ... The octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction.. Terms. Angiotensin Amide ... 1-Asparagine-5-valine Angiotensin II 5-Valine-Angiotensin II Amide Angiotensinamide Hypertensin Pharm Action. Vasoconstrictor ...
DeCS
5 Valine Angiotensin II Amide 5-Valine-Angiotensin II Amide Amide, 5-Valine-Angiotensin II Amide, Angiotensin Angiotensin II, 1 ... 5 Valine Angiotensin II Amide. 5-Valine-Angiotensin II Amide. Amide, 5-Valine-Angiotensin II. Amide, Angiotensin. Angiotensin ... Angiotensin Amide - Preferred Concept UI. M0001200. Scope note. The octapeptide amide of bovine angiotensin II used to increase ... Angiotensin Amide Entry term(s). 1 Asparagine 5 valine Angiotensin II 1-Asparagine-5-valine Angiotensin II ...
E0000163|Adriamycin|doxorubicin
Angiotensin converting enzyme inhibitors. Medical search. Definitions
angiotensin converting enzyme inhibitors. Definitions. Medical Information Search ... Angiotensin Amide. The octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction.. ... Angiotensin, Type 1Receptors, AngiotensinReceptor, Angiotensin, Type 2Angiotensin IAngiotensin Receptor AntagonistsAngiotensin ... Angiotensin, Type 1Receptors, AngiotensinReceptor, Angiotensin, Type 2Angiotensin IAngiotensin Receptor AntagonistsAngiotensin ...
FDA UNII Code (use for SPL) FDA Preferred Term NCI Concept Code
ACUTILOBA ROOT C80317 B25G881UOX ANGELICA ROOT OIL C107262 67IO7RRV7A ANGELICA SEED OIL C107263 7WAL1X78KV ANGIOTENSIN AMIDE ... RELEASING HORMONE D-ARG6 ANALOG ETHYL AMIDE C97490 66KW0E903I SALMON GONADOTROPIN RELEASING HORMONE D-ARG6 ANALOG ETHYL AMIDE ... D-GLUCOSAMINE C77375 4N69717RKW N-ACETYLCYSTEINE AMIDE C87651 V956696549 N-ACETYLGLUCOSAMINE C83975 DA8G610ZO5 N-ACETYL- ...
DeCS 2017 - December 21, 2017 version
1 Asparagine 5 valine Angiotensin II use Angiotensin Amide 1 beta D Arabinofuranosyl Uracil use Arabinofuranosyluracil ... 1 Sarcosine 8 Alanine Angiotensin II use Saralasin 1 Sarcosine 8 Isoleucine Angiotensin II use 1-Sarcosine-8-Isoleucine ... 1-(N-Methylglycine)-8-L-Isoleucine-Angiotensin II use 1-Sarcosine-8-Isoleucine Angiotensin II ... 1 Sar 8 Ile Angiotensin II use 1-Sarcosine-8-Isoleucine Angiotensin II ...
T000001A 23187
1-Asparagine-5-valine T0023795 Valine Angiotensin II Amide T0023795-Valine-Angiotensin II Amide T002379Amide, 5-Valine- ... Angiotensin T002380Angiotensin Amide T002381Hypertensin T002382Angiotensinamide T002383Angiotensin I T002383I, Angiotensin ... Angiotensin II T002389Valyl(5)-Angiotensin II T002390Angiotensin III T002391Des Aspartyl Angiotensin II T002391Des-Aspartyl- ... Angiotensin II T002392Angiotensin II, Des-Asp T002392Des Asp Angiotensin II T002392Des-Asp Angiotensin II T002393Angiotensin ...
Pesquisa | Portal Regional da BVS
Towards this end, four [Y]6 -Angiotensin II analogues are synthesized where amide bonds have been replaced by 1,4-disubstituted ... The peptide hormone angiotensin II regulates blood pressure mainly through the type 1 angiotensin II receptor AT1 R and its ... Angiotensin II (Ang II) is the most dominant effector component of the renin-angiotensin system (RAS) that generally acts ... BACKGROUND: Information about angiotensin II (Ang II), angiotensin-converting enzyme 2 (ACE2), and Ang-(1-7) levels in patients ...
Enalapril/química
Angiotensin converting enzyme (ACE) presents an important role in blood pressure regulation, since that converts angiotensin I ... The NMR and FT-IR studies reveal that in GF4 there is prominent presence of amide and the hydroxyl groups indicating that ... Potential Angiotensin Converting Enzyme Inhibitors from Moringa oleifera. Khan, Huma; Jaiswal, Varun; Kulshreshtha, Saurabh; ... An optimization effort guided by in situ IR analysis resulted in a general amide coupling approach facilitated by N- ...
Project Publications: University of California-Davis: Development and Application of Integrated In Vitro and Cell-Based...
Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm(Manduca sexta: Sphingidae). ... Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension 45(4):759-765. doi:10.1161/01 ... Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem 48(10):3621-3629 ... Inhibition of microsomal epoxide hydrolases by ureas, amides, and amines. Chem Res Toxicol 14(4):409-415. PMID:11304129 ...
TERM
Angiotensin Amide Angiotensin I Angiotensin II Angiotensin II Type 1 Receptor Blockers Angiotensin II Type 2 Receptor Blockers ... Angiotensin III Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Angiotensinogen Angiotensins Angola ... Amide Synthases Amides Amidine-Lyases Amidines Amidinotransferases Amido Black Amidohydrolases Amidophosphoribosyltransferase ... Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor Carbon-Nitrogen Lyases Carbon-Oxygen Ligases Carbon-Oxygen Lyases ...
Lexical Tools
Angiotensin 2 Angiotensin 3,Angiotensin 3 Angiotensin Amide,Angiotensin Amide Angiotensin Converting Enzyme,Angiotensin ... angiotensin ,angiotensin angiotensin II,angiotensin II angiotensin converting enzyme,angiotensin converting enzyme antithrombin ... 5 Valine Angiotensin II Amide 5-Valine-Angiotensin II Amide,5-Valine-Angiotensin II Amide 6 Ketoprostaglandin F1 alpha,6 ... Angiotensin I-Converting Enzyme Inhibitors Angiotensin II,Angiotensin II Angiotensin II ,Angiotensin II Angiotensin II Receptor ...
Biomarkers Search
5. CoMFA and CoMSIA studies of angiotensin (AT1) receptor antagonists.. Datar P; Desai P; Coutinho E; Iyer K. J Mol Model; 2002 ... CoMFA and CoMSIA studies on aryl carboxylic acid amide derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors.. Vyas VK ... 7. QSAR studies on 3-(4-biphenylmethyl) 4, 5-dihydro-4-oxo-3H-imidazo [4, 5-c] Pyridine derivatives as angiotensin II (AT1) ... Nonpeptidic angiotensin II AT₁ receptor antagonists derived from 6-substituted aminocarbonyl and acylamino benzimidazoles. ...
Biomarkers Search
Patents 5612123 - 5612379
Acting on a linear amide linkage in linear amide : Derived from animal tissue (e.g., rennin, etc.)). Patent 5612211: ... Patent 5612365: Angiotensin II receptor antagonists for the treatment and prophylaxis of coronary heart disease. (DRUG, BIO- ... Patent 5612360: Angiotensin II antagonists. (DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS : DESIGNATED ORGANIC ACTIVE ... Patent 5612336: Heterocyclic amide derivatives as tachykinin antagonists. (DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS ...
Lexical Tools
Angiotensin 2 Angiotensin 3,Angiotensin 3 Angiotensin Amide,Angiotensin Amide Angiotensin Converting Enzyme,Angiotensin ... angiotensin ,angiotensin angiotensin II,angiotensin II angiotensin converting enzyme,angiotensin converting enzyme antithrombin ... 5 Valine Angiotensin II Amide 5-Valine-Angiotensin II Amide,5-Valine-Angiotensin II Amide 6 Ketoprostaglandin F1 alpha,6 ... Angiotensin I-Converting Enzyme Inhibitors Angiotensin II,Angiotensin II Angiotensin II ,Angiotensin II Angiotensin II Receptor ...
Suppliers of Biochemicals Worldwide
Pharos : Ligand List
Fatty-acid amide hydrolase 2 (Q6GMR7). 1 Select filter option. G-protein coupled bile acid receptor 1 (Q8TDU6). 1 Select filter ... Metabolism of Angiotensinogen to Angiotensins. 218 Select filter option. Metabolism of proteins. 218 Select filter option. ... Fatty-acid amide hydrolase 1 (O00519). 42 Select filter option. Sn1-specific diacylglycerol lipase alpha (Q9Y4D2). 7 Select ... Fatty-acid amide hydrolase 2. 1 Select filter option. G-protein coupled bile acid receptor 1. 1 ...
PHOENIX BIOTECH RIA
Angiotensin I (Human, Rat, Mouse, Canine) - RIA Kit 1 kit $545.00 MRK-002-12 Angiotensin II (Human, Rat, Mouse, Canine) - ... Coupling Factor 6 (CF6) Amide (Human) - RIA Kit 1 kit $625.00 RK-007-54 Coupling Factor 6 (CF6) Precursor (55-108) Amide (Human ... Angiotensin II (Human, Rat, Mouse, Canine) - RIA Kit 1 kit $575.00 RK-005-21 ANP (104-116), Prepro (Human) - RIA Kit 1 kit $ ... AGRP (83-132)-Amide (Human) - RIA Kit 1 kit $625.00 RK-033-72 AMP-IBP5 / prepro IGFBP-5 (193-214) peptide 4 (Human, Rat, Mouse ...
Laminin Pentapeptide YIGSR-NH|sub|2|/sub| › PeptaNova
YIGSR Amide 4194-v 0.5 mg , 50.00 EUR Tyr-Ile-Gly-Ser-Arg-NH2 (M.W. ... Val5]-Angiotensin I (Bovine). 35,00 €. excl. 19% VAT [Val5]-Angiotensin I (Bovine). ... Val5]-Angiotensin II. 25,00 €. excl. 19% VAT [Val5]-Angiotensin II. ... Our product Laminin Peptapeptide Amide (YIGSR-amide) will be shipped at room temperature. Information about product specific ...
Oral history interview with Miguel A. Ondetti - Science History Institute Digital Collections
... because it has blocked the conversion of angiotensin one into angiotensin two that is the agent that increases blood pressure. ... Once that is said, you have to realize that due to the variety of amino acid involved in these amide bonds, the variety of ... Keywords Lancet (journal) • Publications • Research • Science (journal) • Angiotensin converting enzyme--Inhibitors • Captopril ... From all we knew and what they said, we believed that it should be possible to make a new type of inhibitor of angiotensin ...
Mugesh research group at the Indian Institute of Science
Bhuyan, B. J.; Mugesh, G. LPO-catalyzed iodination of angiotensins and inhibition by anti-thyroid drugs. Presented a Poster ... A Biomimetic Study on the Unexpected Formation of a Sulfenyl Amide Intermediate. Presented a Poster in the In-house Symposium ... Bhuyan, B. J.; Mugesh, G. Angiotensin Converting Enzyme Inhibitors with Antioxidant Properties. Presented a Poster in the ... Bhuyan, B. J.; Mugesh, G. Design and Synthesis of Angiotensin Converting Enzyme Inhibitors Having Antioxidant Activity. ...
HeteroCycles
Buy Chemicals for Pharmaceutical Research Online - Page 3 of 244 - Advanced ChemTech
Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax plancyi fukienensis: A Prototype of...
"Comparison of blood pressure responses to intra-arterial and intra-venous injections of angiotensin I, angiotensin II and ... L. Wang, Y. Chen, M. Yang et al., "Peptide DV-28 amide: an inhibitor of bradykinin-induced arterial smooth muscle relaxation ... comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating ... A. Benetos, B. I. Levy, P. Lacolley, F. Taillard, M. Duriez, and M. E. Safar, "Role of angiotensin II and bradykinin on aortic ...
PIROXICAM
NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor ... and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N- ... Patients taking angiotensin converting enzyme (ACE) inhibitors, thiazide diuretics, or loop diuretics may have impaired ... ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: ...
Isolating angiotensin converting1
- Ondetti describes acquiring venom for isolation of enzyme inhibitors, isolating angiotensin converting enzyme inhibitors, and learning to isolate and sequence peptides in competition with researchers at Brookhaven National Laboratories. (sciencehistory.org)
RENIN-ANGIOT3
- They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system . (lookformedical.com)
- Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. (lookformedical.com)
- A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN , leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM . (lookformedical.com)
Enzyme10
- Angiotensin converting enzyme inhibitors. (lookformedical.com)
- It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. (lookformedical.com)
- It is converted to angiotensin II , a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. (lookformedical.com)
- An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE . (lookformedical.com)
- Renin , an enzyme produced in the kidney , acts on angiotensinogen , an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I . Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II , an extremely powerful vasoconstrictor. (lookformedical.com)
- Angiotensin-converting enzyme also breaks down BRADYKININ , a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM. (lookformedical.com)
- BACKGROUND: Information about angiotensin II (Ang II), angiotensin-converting enzyme 2 (ACE2), and Ang-(1-7) levels in patients with COVID-19 is scarce. (bvsalud.org)
- In 1973, for practical reasons, Squibb's angiotensin converting enzyme [ACE] inhibitor work officially ended, but Ondetti's interest in the subject continued. (sciencehistory.org)
- This vasoregulatory role has been exploited clinically through the introduction of inhibitors to the angiotensin-II generating/bradykinin-degrading protease, angiotensin-converting enzyme (ACE), that still represent the front-line therapeutics for the treatment of hypertension [ 6 , 7 ]. (hindawi.com)
- Although a number of drugs, including angiotensin-converting enzyme inhibitors, calcium channel blockers and angiotensin II receptor antagonists, has been widely used to treat myocardial ischemia in western medicine, the usefulness of these drugs has been limited due to their serious adverse effects, such as cardiac depression or even, proarrhythmic effects ( 1 ). (spandidos-publications.com)
Peptide3
- The peptide hormone angiotensin II regulates blood pressure mainly through the type 1 angiotensin II receptor AT1 R and its downstream signaling proteins Gq and ß-arrestin. (bvsalud.org)
- Ondetti was part of a group effort to synthesize gastrointestinal hormones, particularly secretin, a peptide amide that stimulates the pancreas to secrete bicarbonate and water. (sciencehistory.org)
- A major physiological role for the peptide in mammals, including humans, is in the maintenance of systemic blood pressure through its role in dilation of arterial smooth muscle that effectively counteracts the constrictor effects of angiotensin-II [ 3 - 5 ]. (hindawi.com)
Octapeptide1
- The octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction. (bvsalud.org)
RECEPTOR10
- To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II , patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS . (lookformedical.com)
- An angiotensin receptor subtype that is expressed at high levels in a variety of adult tissues including the CARDIOVASCULAR SYSTEM, the KIDNEY , the ENDOCRINE SYSTEM and the NERVOUS SYSTEM. (lookformedical.com)
- Activation of the type 1 angiotensin receptor causes VASOCONSTRICTION and sodium retention. (lookformedical.com)
- An angiotensin receptor subtype that is expressed at high levels in fetal tissues. (lookformedical.com)
- Many effects of the angiotensin type 2 receptor such as VASODILATION and sodium loss are the opposite of that of the ANGIOTENSIN TYPE 1 RECEPTOR. (lookformedical.com)
- Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR. (lookformedical.com)
- Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. (lookformedical.com)
- An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II . (lookformedical.com)
- Angiotensin II type I receptor (AT1R) is an ideal model system to study the molecular basis of bias since it has multiple ß-arr2 and Gq protein biased agonists as well as experimentally solved three dimensional structures. (bvsalud.org)
- Using Molecular Dynamics (MD) simulations for the Angiotensin II type I receptor (AT1R) bound to ten different agonists, we infer that the agonist bound receptor samples conformations with different relative weights, from both the inactive and active state ensembles of the receptor. (bvsalud.org)
Analogs1
- Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN . (lookformedical.com)
Proteins1
- Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells. (lookformedical.com)
Stimulates1
- In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney . (lookformedical.com)
Blood2
- Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure . (lookformedical.com)
- A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A . It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II , a vasoconstrictor and important regulator of arterial blood pressure . (lookformedical.com)
Renin angiot2
- 12. The role of renin angiotensin system antagonists in the prevention of doxorubicin and trastuzumab induced cardiotoxicity. (nih.gov)
- 81 Measurement of medullary blood flow 81 Electrolyte and water transport 82 Electrolyte fluxes in renal tubules of rabbit- 82 Red cell ghosts 83 Action of vasopressin and other hormones 84 Vasopressin 84 Aldosterone and renin-angiotensin system. (nih.gov)
Receptor1
- Stimulation of the angiotensin II type 2 receptor (AT2R) evokes protective effects in various cardiovascular diseases. (bvsalud.org)
Vasopressin1
- 6] Release of endothelin-1 is triggered by vasoactive stimuli, including angiotensin, vasopressin, and transforming growth factor-beta (TGF-beta)[7] Conflicting results regarding the levels of endothelin-1 in patients with primary Raynaud phenomenon are noted. (medscape.com)
Role2
- Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20-HETE (20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the pathophysiology of AngII (angiotensin II)-dependent forms of hypertension and the associated target organ damage. (nih.gov)
- 13. The Cardioprotective Role of N-Acetyl Cysteine Amide in the Prevention of Doxorubicin and Trastuzumab-Mediated Cardiac Dysfunction. (nih.gov)
