The octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
An angiotensin receptor subtype that is expressed at high levels in a variety of adult tissues including the CARDIOVASCULAR SYSTEM, the KIDNEY, the ENDOCRINE SYSTEM and the NERVOUS SYSTEM. Activation of the type 1 angiotensin receptor causes VASOCONSTRICTION and sodium retention.
Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells.
An angiotensin receptor subtype that is expressed at high levels in fetal tissues. Many effects of the angiotensin type 2 receptor such as VASODILATION and sodium loss are the opposite of that of the ANGIOTENSIN TYPE 1 RECEPTOR.
A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.
Agents that antagonize ANGIOTENSIN RECEPTORS. Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR.
Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.
A heptapeptide formed from ANGIOTENSIN II after the removal of an amino acid at the N-terminal by AMINOPEPTIDASE A. Angiotensin III has the same efficacy as ANGIOTENSIN II in promoting ALDOSTERONE secretion and modifying renal blood flow, but less vasopressor activity (about 40%).
An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. In immunology, it is the rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. (Dorland, 28th ed)
The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Information or data used to ensure the safe handling and disposal of substances in the workplace. Such information includes physical properties (i.e. melting, boiling, flashing points), as well as data on toxicity, health effects, reactivity, storage, disposal, first-aid, protective equipment, and spill-handling procedures.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Compounds based on fumaric acid.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
A generic term for all substances having the properties of stretching under tension, high tensile strength, retracting rapidly, and recovering their original dimensions fully. They are generally POLYMERS.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Use of electric potential or currents to elicit biological responses.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Immunologic production of antiangiotensin. I. Preparation of angiotensin-protein complex antigen. (1/13)

Angiotensin II was coupled with bovine gamma-globulin (BGG) through the following series of reactions. See PDF for Structure By determinations of the aromatic amine and tyrosine contents of p-aminobenzoylangiotensin II, the number of p-aminobenzoyl residues introduced per molecule of angiotensin II was calculated. Absorption spectra (between 250 and 500 mmicro) of BGG complexes of p-aminobenzoylangiotensin II and six different para substituted aromatic amines were compared. Specific activities (dog units/millimicromole) of the different intermediate products were determined. Presence of a terminal, free amino group does not appear to be an absolute requirement for the biological activity of angiotensin II, since substitution of a p-aminobenzoyl radical in this group yields a product with 40 to 50 per cent of the activity of the parent compound. Angiotensin I, on the other hand, is completely inactivated under identical circumstances. Possible implication of this finding has been discussed.  (+info)

Immunologic production of antiangiotensin. II. Production and detection of antiangiotensin. (2/13)

The parenteral administration of benzoylangiotensin II-azo-BGG to rabbits produced an antiserum with antiangiotensin activity. Antiangiotensin inhibited the biological action of p-aminobenzoylangiotensin II, valine(5)-angiotensin II (free acid form), isoleucine(5)-angiotensin II and valine(5)-angiotensin II (amide form), but it was totally inert towards angiotensin 1. Antiangiotensin activity was distinguished from that of serum angiotensinase by the following observations: (a) an angiotensinase-free gamma-globulin fraction contained antiangiotensin, (b) angiotensinase inactivated angiotensin II (both the amide and free acid forms) and angiotensin I in contrast to the remarkable specificity for angiotensin II exhibited by antiangiotensin. Serological demonstration of antiangiotensin included: (a) a comparison of its precipitin reaction with the angiotensin BGG complex with the reaction with BGG alone, (b) the partial inhibition of the precipitin reaction with the angiotensin BGG complex by angiotensin II, (c) a precipitin reaction with a different angiotensin II protein complex (cat serum). Angiotensin II administered parenterally as the free polypeptide was not antigenic.  (+info)

Some pharmacological actions of synthetic analogues of angiotensinamide. (3/13)

In order to evaluate the importance of some structural features of asparagyl(1)-Valyl(5)-angiotensin II (angiotensinamide) for its pharmacological actions, the relative potencies of angiotensinamide and five peptide analogues were studied on the blood pressure of the rat, the isolated rat uterus and the isolated guinea-pig ileum. All the modifications of the angiotensinamide structure that were studied led to a decrease of potency which, however, was not the same on all three preparations. The importance of the guanido group, the phenolic group and the length of the peptide chain for the pharmacological activities of these peptides is discussed.  (+info)

Actions of some peptides on bronchial muscle. (4/13)

The decapeptide kallidin-10, substance P and angiotensin increased the resistance of guinea-pig lungs to inflation; lysine- or arginine-vasopressin and oxytocin were inactive. Acetylsalicylate antagonized this action of kallidin-10, as it does that of bradykinin, but it failed to antagonize substance P or angiotensin. Bradykinin also increased resistance to inflation of rabbit lungs and, to a lesser extent, rat lungs. It caused a relatively slow contraction of guinea-pig tracheal and bronchial muscle in vitro, but it did not contract isolated rabbit, dog or human bronchus. The relative potencies of different substances on different bronchial test preparations, and also in different species, were not parallel.  (+info)

Pharmacological actions of pepsitensin. (5/13)

In confirmation of the results of Croxatto and his co-workers, plasma proteins incubated with pepsin yielded a substance (pepsitensin) with pressor activity. Euglobulin gave a much higher yield than the other plasma protein fractions. Incubation for 4 hr at pH 4 gave high yields of pressor activity (pepsitensin) but no antidiuretic activity; incubation of euglobulin for 4 hr at pH 2.5 yielded extracts with antidiuretic as well as pressor activity. Incubation for 8 to 11 hr at pH 2.5 produced the highest yield of both activities. Further incubation, at the same pH, up to 20 hr caused a rapid decline in the pressor activity of the extracts, but the antidiuretic activity was much more resistant to destruction by pepsin. Pepsitensin was found to be very soluble in water and poorly soluble in organic solvents. It is not inactivated by thioglycollate. In blood pressure assays some animals did not respond to pepsitensin, and nephrectomized (17 to 24 hr) rats were found to be more suitable preparations. Pepsitensin was shown to exert pressor effect by direct action on the blood vessels. Its pressor action could be differentiated from that of tyramine, dimethylphenylpiperazine, nicotine, noradrenaline and Pitressin but not from that of angiotensin. The isolated guinea-pig ileum and the rat uterus were equally sensitive to angiotensin and pepsitensin. In paper chromatograms, in the solvent system butanol-acetic acid-water, the R(F) of pepsitensin was very similar to that of angiotensin.  (+info)

Stimulation of intestinal nervous elements by angiotensin. (6/13)

The stimulation of nervous elements in the intestine by the polypeptide angiotensin has been examined. Comparisons between nicotine, a neurotropic agent, acetylcholine which exerts principally a musculotropic action and angiotensin have been made by examining their interactions with hexamethonium and the anticholinesterase 1,5-di-(p-N-allyl-N-methylaminophenyl)pentan-3-one dibromide in both the rabbit and guinea-pig ileum. The effect of atropine on the responses of the guinea-pig ileum and botulinum toxin on the responses of the rabbit ileum to angiotensin was also tested. The results show that angiotensin causes most of its contractile response in both the guinea-pig and rabbit ileum by an indirect action, through the stimulation of nervous tissue.  (+info)

Home blood pressure monitoring in diabetes. (7/13)

Forty three children with diabetes were recruited to evaluate home blood pressure monitoring using an electronic oscillometric sphygmomanometer (Philips HP5330). This device was found to be simple to use and reliable. It fulfilled the accuracy criteria of the American Association for the Advancement of Medical Instrumentation for both systolic and diastolic blood pressure and those of the British Hypertension Society for systolic blood pressure. Thirty eight children successfully measured their own blood pressure at home and taught other family members to do the same. The results indicate that home blood pressure monitoring is of value in the management of diabetic children.  (+info)

Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation. (8/13)

 (+info)

Define angiotensin amide. angiotensin amide synonyms, angiotensin amide pronunciation, angiotensin amide translation, English dictionary definition of angiotensin amide. n. Any of several polypeptide hormones, designated by Roman numerals, that are involved in the regulation of blood pressure, especially one of them,...
The stainability of neural elements is determined during the various stages of tissue preparation which precede impregnation.. The hypothesis (Romanes, 1950) that variations in the physiological state of the neurones at the time of fixation might influence the stain was examined. Feeding and anaesthesia did not influence the staining of gastric nerve fibres under the conditions of the experiments.. A study was made of fixing fluids for Bodian staining. A picric-acetic-alcohol mixture and alcoholic Bouin were convenient and effective, each being superior to formaldehyde-acetic-alcohol. For overnight fixation formaldehyde solution neutralized with calcium carbonate was satisfactory, but where prolonged fixation is permissible formaldehyde neutralized with excess of magnesium carbonate gave superior results.. Attention was drawn to the probability that the final stain could be improved by pretreatment of mounted sections before silvering. Dewaxed sections were treated individually with 27 ...
Calcium Carbide Calcium Carbide is a chemical compound containing calcium and carbide, with a chemical formula of CaC2. Pure Calcium Carbide is colorless,
Read Accentures report about how to navigate historic regulatory change and the implications for mortgage lenders resulting from the TILA-RESPA Integrated Mortgage Disclosure Regulation.
Croxatto, H.R., Huidobro, F., Croxatto, R. et Salvestrini, H., Action cholinestérasique du sang veineux pendant lexcitation musculaire directe et indirecte, Compt. Rend. Seanc. Soc. Biol. Paris, 130, p. 326 (1939); Croxatto, H.R. and Croxatto, R., Pepsitensin - A hypertensin-like substance produced by peptidic digestion of proteins, Science, 95, p. 101 (1942); Croxatto, H.R., Rojas, G. and Barnafi, L., The liberation of antidi- uretic factor by the hypertensinogen pepsin reaction, Acta Physiol. Latinoamer., 2, p. 178 (1951); Croxatto, H.R., Pereda, T. and Mellada, R., Peptides with oxytocin and pressor activity obtained from acidified rat serum, Nature, 184, p. 1496 (1959); Croxatto, H.R. and Barnafi, L., Hormone and hormone-like activity of active polypeptides, Rec. Prog. Horm. Res., 16, p. 236 (1961); Croxatto, H.R. and Belmar, J., Hypertensive effects of bradykinin in rats, Nature, 192 (4805), p. 879 (1961); Croxatto, H.R., Pereda, T., Belmar, J. and Labarca, E., Polypeptides ...
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By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
Medical marijuana shops in Weymouth would have to be located 500 feet away from a school, day care, playground, park or any area where children gather under a new zoning amendment proposed by the planning board.
The examination of synthetic valyl-5-angiotensin II-amide in the conscious dog revealed the following:. 1. Both the arterial and the central venous pressure responses exhibit tachyplylaxis when high doses of angiotensin II are administered, althoug not when medium or low doses are given. Cross-tachyphylaxis can be demonstrated between renin and angiotensin II but not between either of these and norepinephrine. These results suggest that tachyphylaxis to renin is due to tachyphylaxis to angiotensin.. 2. Angiotensin II and norepinephrine provoke a dose-dependent increase in central venous pressure. The threshold dose is about 10 times higher than that necessary for the effect on arterial pressure. In doses eliciting the same increase of arterial blood pressure, norepinephrine is about twice as active on the venous pressure as angiotensin II.. 3. Anesthesia and atropinization both reduce or abolish the effect of angiotensin II as well as that of norepinephrine on the venous pressure, indicating the ...
1. The threshold pain stimulus was elevated in cats after doses of 3.0-15.0 mgm. per kilogram of body weight of 2-amino-6-methylheptane hydrochloride intraperitoneally.. 2. Local anesthesia was produced by tropical application of solutions of the hydrochloride or free base of 2-amino-6-methylheptane to rabbits eyes.. 3. Intravenously in dogs anesthetized with pentobarbital sodium, 2-amino-6-methylheptane hydrochloride exhibited 1/500-1/1000 the pressor activity of epinephrine.. 4. As determined with a Cushny Myocardiograph, 2-amino-6-methylheptane hydrochloride was found to cause an increase in cardiac rate and amplitude of contraction.. 5. Intravenously in dogs, anesthetized with pentobarbital sodium, doses of 0.5 to 1.0 mgm. per kilogram of body weight of 2-amino-6-methylheptane hydrochloride had no detectable effect on the small intestine, detrusor of the urinary bladder, urine secretion or respiration.. 6. In general, concentrations of 1:10,000 to 1:200,000 of 2-amino-6-methylheptane ...
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
DEPARTMENT OF PHARMACOLOGY BPT QUESTION BANK GENERAL PHARMACOLOGY AND ANS Long Essay: 1. 2. 3. #. $. Classify β blockers. Write the pharmacological actions and…
PERINEURIUM AND NEUROGLIA. 279. bellum and cerebrum, between the granules which I have already (p. 269) described to you as connected with large ganglion-cells, and the nuclei of the connective tissue. Whenever the parts are seen severed from their connections, it is not easy to make the distinction, and a positive decision is only possible as long as the parts are viewed in their natural position.. Now it is ccrtainlyof considerable importance to know that in all nervous parts, in addition to the real nervous elements, a second tissue exists, which is allied to the large group of formations, which pervade the whole body, and with which we have in the previous lectures become acquainted under the name of connective tissues. In considering the pathological or physiological conditions of the brain or spinal marrow, the first point is always to determine how far the tissue which is affected, attacked or irritated, is nervous in its nature, or merely an interstitial substance. We thus obtain at the ...
β-Methylphenethylamine (β-Me-PEA, BMPEA), or 1-amino-2-phenylpropane, is an organic compound of the phenethylamine class, and a positional isomer of the drug amphetamine, with which it shares some properties. In particular, both amphetamine and β-methylphenethylamine are human TAAR1 agonists. In appearance, it is a colorless or yellowish liquid. Relatively little information has been published about this substance. Hartung and Munch reported that it had good antihypotensive (pressor) activity in experimental animals, and that it was orally active. The MLD (minimum lethal dose) for the HCl salt was given as 500 mg/kg (rat, s.c.) and 50 mg/kg (rabbit, i.v.). A study by Graham and co-workers at the Upjohn Co., comparing a large number of β-methylphenethylamines substituted on the benzene ring showed that β-methylphenethylamine itself had 1/700 x the pressor activity of epinephrine, corresponding to ~ 1/3 the potency of amphetamine. The β-methyl compound also had ~ 2 x the broncho-dilating ...
Azulfidine - When a patient has become sensitized to a foreign substance, he may reveal this sensitivity: by swelling of the nose and eyes, as in hay fever; by swelling of the skin, as in urticaria; by spasm and swelling of other portions of the body, such as the colon; but the most characteristic manifestation, and perhaps the most serious, is that of spasm of the bronchial muscles.
Latin name: Chlordiazepoxydum. ATX code: N05BA02, N05BA52. Chemical formula: C16H14ClN3O. CAS code: 58-25-3. Chemical name. CAS: 58-25-3. Chemical properties. Pharmacological action. Pharmacodynamics and pharmacokinetics. Indications for use. Contraindications. Side effects. Chlordiasepoxide, the instructions for use (Method and dosage) overdose. Interaction. Terms of sale. Special instructions. With alcohol. Analogues. Reviews. The price where to buy Chlordiasepoxide.
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1910 (1909), The migration of nervous elements into the dorsal and ventral nerve roots of embryos of the pig. Proceedings of the Iowa Academy of Science for 1909, 16: 217-220 and plate. 1913, The embryology and larval development of Bairdiella chrysura and Anchovia mitchilli. Bull. Bureau of Fisheries, 33, 3-19. 1913, Notes on the habits, morphology of the reproductive organs, and embryology jot the viviparous fish Gambusia affinis. Bull. Bureau of Fisheries, 33, 181- . 1914, Notes on the embryology and larval development of five species of teleostean fishes. Bull. Bureau of Fisheries, 34, 409-429. 1915 (with Lewis Radcliffe), Notes on the embryology and larval development of twelve teleostean fishes. Bull. Bureau of Fisheries, 35, 89-134. 1916, The histological basis of adaptive shades and colors in the flounder, Peralichthys albiguttus. Bull. Bureau of Fisheries, 35, 5-28. 1916, A note on superfetation. Interstate Med. Journal, 23, 1-11. 1920, Retention of dead foetuses in utero and its ...
Adaikan, G P., Tai, M.Y., Lau, L.C. (1984). A comparison of some pharmacological actions of prostaglandin E1, 6-oxo-PGE1and PGI2. Prostaglandins 27 (4) : 505-516. [email protected] Repository. https://doi.org/10.1016/0090-6980(84)90086- ...
BUY Theo-24 Cr ONLINE (Theophylline) PRICE DISCOUNT FOR SALE ORDER CHEAP GET NO PRESCRIPTION Theo-24 Cr causes dilation of the bronchial tubes by relaxing bronchial muscle. It is effective against chronic obstructive pulmonary diseases such as asthma, pulmonary emphysema, and bronchitis.
Let us now take a look at some of the studies that have convinced both scientists and doctors alike that Forskolin has therapeutic benefits and can treat asthma symptoms in patients:. According to a study published in 2003 conducted by Martin Hum DHD, Ph. D examining the causes of asthma and how dietary therapy can help, mentions Forskolin as one of the most effective herbal remedies for treating asthma. He stated based on numerous clinical trials that he had studied and observed. In this report, he states that a small double blind trial showed that when Forskolin powder was inhaled by patients with asthma, it helped lower lung spasms in comparison to placebo. (2). In a report published in Volume 11 of Alternative Medicine Review 2006 highlighted the study by Bauer K. and Sertl K,that showed the benefits of Forskolin for treating asthma. The report stated that aerosolized dry powder of Forskolin helped provide relax the bronchial muscles and also alleviated asthma symptoms. It further supported ...
London, Sep 14 (IANS) Researchers have extracted an active pharmaceutical substance from the leaves of a common ornamental plant - coralberry - which could provide hope for people with asthma. The findings, led by researchers at the University of Bonn in Germany and asthma specialists from the UK, showed that the leaves of the coralberry contain a substance with the cryptic name FR900359.. The extracts when used in mice almost inhibited the characteristic contraction of the airways. Further, the study found that FR900359 is very effective at preventing the bronchial muscles from contracting. Asthmatics regularly suffer from these pronounced contractions preventing adequate ventilation of the lungs. The resulting shortness of breath can be life-threatening.. The compound in the coralberry leaves relieves these spasms and is supposedly more effective and has a more prolonged action than the most common asthma drug salbutamol, the researchers noted in the paper published in the journal Science ...
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Glycine Agents: Substances used for their pharmacological actions on glycinergic systems. Glycinergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.
Upper side: impressed with AX in an equilateral hexagon. Pharmacological action, proviron balances a deficiency of androgen formation which begins to fall gradually with increasing age. Proviron has had a Upper side: impressed with AX in an equilateral hexagon. Pharmacological action, proviron balances a deficiency of androgen formation which begins to fall gradually with increasing age. Proviron has had a lifetime of esterification experience. These effects result in a decrease in water buildup in the body, which gives the muscles a leaner, harder look. Nella oligospermia consigliabile una posologia di 50-75 mg di Proviron 50 mg 20 cpr (1-1 compressa) al d per la durata di un ciclo spermiogenetico (circa 90 giorni). Producing esters has become second nature. Indicaes de Proviron diminuio da capacidade fisica e mental em paciente de meia-idade ou idade avanada: distrbios resultantes de deficincia andrognica, tais como, reduo de eficincia, fatigabilidade maior, diminuio da capacidade de ...
1. Competitive or non-competitive inhibition of the myotropic and pressor response of angiotensin II is dependent on the nature of the substituent in position 8 of the antagonist peptide analogue. Substituents in other positions of the molecule, particularly position 1, contribute greatly to the potency of these antagonists.. 2. As is evidenced after adrenalectomy or after blockade with phentolamine and phenoxybenzamine, the initial pressor activity observed with all the antagonistic peptides is partially due to the release of catecholamines and partially to a direct myotropic effect.. 3. [Sar1, Thr8]angiotensin II has been found to possess the lowest agonist to antagonist ratio of all antagonists tested.. 4. [Des-Asp1, Ile8]angiotensin II selectively and specifically inhibits the release of aldosterone from adrenal cortex. Thus, unlike angiotensin II, this heptapeptide has pronounced organ specificity, suggesting that the heptapeptide (angiotensin III) is the aldosterone-releasing ...
Home Blood Pressure Monitoring (HBPM) and Pharmaceutical care have been proposed to improve therapeutic compliance and to guide treatment decisions, but their effects on BP control are still under debate.. This is a factorial randomized controlled trial including adult hypertensive patients under drug treatment but with office BP and 24h ABPM uncontrolled. Participants will be allocated to one of four groups: HBPM; HBPM and Pharmaceutical care; Pharmaceutical care; or control. All participants will receive usual care for high blood pressure. Participants will be followed for 60 days. ...
Adults need ongoing blood pressure assessment through their lives because 1 in 4 Canadians is affected by hypertension (high blood pressure) and 50% of 50 year-old adults are hypertensive.
... angiotensin i MeSH D23.469.050.050.050 - angiotensin ii MeSH D23.469.050.050.050.050 - angiotensin amide MeSH D23.469.050.050. ... angiotensin iii MeSH D23.469.050.175 - eicosanoids MeSH D23.469.050.175.450 - leukotrienes MeSH D23.469.050.175.450.400 - ... 050.700 - saralasin MeSH D23.469.050.050.050.725 - 1-sarcosine-8-isoleucine angiotensin ii MeSH D23.469.050.050.075 - ...
... (INN; BAN and USAN angiotensin amide) is a potent vasoconstrictor used as a cardiac stimulant. It is a ...
1982), "Angiotensin-Converting Enzyme Inhibitors: Importance of the Amide Carbonyl of Mercaptoacyl Amino Acids for Hydrogen ... It showed inhibitory effect of angiotensin I and bradykinin without having any effects on angiotensin II. Then researchers ... "Roles of the Two Active Sites of Somatic Angiotensin-Converting Enzyme in the Cleavage of Angiotensin I and Bradykinin: ... Angiotensin I is mainly hydrolyzed by the C-domain in vivo but bradykinin is hydrolyzed by both active sites. Thus, by ...
... (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug ... "The Procognitive and Synaptogenic Effects of Angiotensin IV-Derived Peptides Are Dependent on Activation of the Hepatocyte ... "Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle1-Angiotensin IV Analogs". The Journal ... "Evaluation of metabolically stabilized angiotensin IV analogs as pro-cognitive/anti-dementia agents". The Journal of ...
... angiotensin i MeSH D12.644.456.073.041 - angiotensin ii MeSH D12.644.456.073.041.050 - angiotensin amide MeSH D12.644.456.073. ... angiotensin i MeSH D12.644.400.070.078 - angiotensin ii MeSH D12.644.400.070.080 - angiotensin iii MeSH D12.644.400.085 - ... angiotensin iii MeSH D12.644.456.073.070 - angiotensinogen MeSH D12.644.456.120 - antipain MeSH D12.644.456.193 - bradykinin ... 041.800 - saralasin MeSH D12.644.456.073.041.815 - 1-sarcosine-8-isoleucine angiotensin ii MeSH D12.644.456.073.055 - ...
... angiotensin - angiotensin II - angiotensin receptor - ankyrin - annexin II - antibiotic - antibody - apoenzyme - apolipoprotein ... amide - amine - amino - amino acid - amino acid receptor - amino acid sequence - amino acid sequence homology - aminobutyric ...
A polypeptide is a single linear chain of many amino acids (any length), held together by amide bonds. A protein consists of ... An octapeptide has eight amino acids (e.g., angiotensin II). A nonapeptide has nine amino acids (e.g., oxytocin). A decapeptide ... A water molecule is released during formation of each amide bond. All peptides except cyclic peptides have an N-terminal (amine ... has ten amino acids (e.g., gonadotropin-releasing hormone and angiotensin I). A neuropeptide is a peptide that is active in ...
It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide ... CES1 is responsible for the activation of many prodrugs such as angiotensin-converting enzyme (ACE) inhibitors, oseltamivir, ... These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing xenobiotics and drugs such as cocaine and ... focus on angiotensin-converting enzyme inhibitors". Drug Metab Dispos. 42 (1): 126-33. doi:10.1124/dmd.113.053512. PMID ...
This leads to the product angiotensin I (Ang I) which is a decapeptide. Ang I is broken down by the angiotensin-converting ... The amide group forms a hydrogen bond with a secondary amine group of Ser76. The S1 and S1′ pockets are occupied by the two ... Ferrario, C. M.; Iyer, S. N. (1998). "angiotensin-(1-7): A bioactive fragment of the renin-angiotensin system". Regulatory ... design Angiotensin Angiotensin II receptor antagonist Beta blocker Circulatory system Discovery and development of angiotensin ...
In linear amides) Urease (EC 3.5.1.5) Category:EC 3.5.2 (In cyclic amides) Beta-lactamase (EC 3.5.2.6) Category:EC 3.5.3 (In ... EC 3.4.15 Angiotensin converting enzyme Category:EC 3.4.21 Serine protease Chymotrypsin (EC 3.4.21.1) Trypsin (EC 3.4.21.4) ...
Angiotensin II stimulates AVP secretion, in keeping with its general pressor and pro-volumic effects on the body. Atrial ... with the cysteine residues forming a disulfide bond and the C-terminus of the sequence converted to a primary amide. Lysine ... Matsukawa T, Miyamoto T (March 2011). "Angiotensin II-stimulated secretion of arginine vasopressin is inhibited by atrial ... natriuretic peptide inhibits AVP secretion, in part by inhibiting Angiotensin II-induced stimulation of AVP secretion. Cortisol ...
... and the target enzyme of Captopril, angiotensin-converting enzyme, have very similar structures, as they ... Salt linkage with positively charged Arg-145 Hydrogen bond from Tyr-248 Hydrogen bond from the nitrogen of the Asn-144 amide ... Recent biomedical research on collagenase, enkephlinase, and angiotensin-converting enzyme used carboxypeptidase A for ... lower blood pressure through the renin-angiotensin-aldosterone system. Carboxypeptidase A (CPA) contains a zinc (Zn2+) metal ...
September 2005). "Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent ... January 2011). "Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors- ...
December 2006). "Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 ... is prevented through angiotensin II activation of a tyrosine phosphatase". The Journal of Pharmacology and Experimental ... neutralized by angiotensin II AT(2) receptor activation Bradanicline - partial agonist, in development for treatment of ...
Mapracorat is one of a number of trifluoropropanolamines and -amides which are less obviously steroid-like in structure. Other ... Examples of glucocorticoid-responsive genes include those that encode annexin A1, TSC22D3 (also known as GILZ), angiotensin- ...
Also within this conserved family is a C-terminus that has an amide added to it. This family which kisspeptin includes ... Lastly, the kisspeptin-angiotensin II pathway of producing aldosterone is increased. Aldosterone that comes from the ...
Kidney failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin ... January 2013). "A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase". Journal of the American ... At these elevated levels, angiotensin II also constricts the afferent arteriole into the glomerulus in addition to the efferent ... enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid amide hydrolase (FAAH). ...
The amide form of nicotinic acid, named nicotinamide, acts as a vitamin although neither activates the GPR109A nor exhibits the ... GPER also regulates components of the renin-angiotensin system, which also controls blood pressure, and is required for ...
Rearrangement of this intermediate leads to protonation of the scissile amide which results in the splitting of the substrate ... Angiotensin-converting enzyme. 3.4.16. *Serine type carboxypeptidases: Cathepsin A. *DD-transpeptidase ...
... fatty acid amide hydrolase EC 3.5.1.100: (R)-amidase EC 3.5.1.101: L-proline amide hydrolase EC 3.5.1.102: 2-amino-5- ... angiotensin-converting enzyme 2 EC 3.4.18.1: cathepsin X EC 3.4.19.1: acylaminoacyl-peptidase EC 3.4.19.2: peptidyl- ...
2bub: CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A REVERSED AMIDE INHIBITOR ... Angiotensin-converting enzyme. 3.4.16. *Serine type carboxypeptidases: Cathepsin A. *DD-transpeptidase ...
In humans, the IGF2 gene is located on chromosome 11p15.5, a region which contains numerous imprinted genes. In mice this homologous region is found at distal chromosome 7. In both organisms, Igf2 is imprinted, with expression resulting favourably from the paternally inherited allele. However, in some human brain regions a loss of imprinting occurs resulting in both IGF2 and H19 being transcribed from both parental alleles.[6] The protein CTCF is involved in repressing expression of the gene, by binding to the H19 imprinting control region (ICR) along with Differentially-methylated Region-1 (DMR1) and Matrix Attachment Region −3 (MAR3). These three DNA sequences bind to CTCF in a way that limits downstream enhancer access to the Igf2 region. The mechanism in which CTCF binds to these regions is currently unknown, but could include either a direct DNA-CTCF interaction or it could possibly be mediated by other proteins. In mammals (mice, humans, pigs), only the allele for insulin-like growth ...
... and does not result in cross-allergy to amides.[13][14] Therefore, amides can be used as alternatives in those patients. ... renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor antagonists. *Renin inhibitors. *Antihyperlipidemics * ... Esters are prone to producing allergic reactions, which may necessitate the use of an amide. The names of each locally clinical ... Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom) ...
Category:EC 3.5.2 (In cyclic amides) *Beta-lactamase (EC 3.5.2.6) ... Angiotensin converting enzyme. *Category:EC 3.4.21 *Serine ...
du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG, Gordon S (1953). "The synthesis of an octapeptide amide with the ... its C-terminus has been converted to a primary amide and a disulfide bridge joins the cysteine moieties.[116] Oxytocin has a ... in the sequence cysteine-tyrosine-isoleucine-glutamine-asparagine-cysteine-proline-leucine-glycine-amide (Cys - Tyr - Ile - Gln ... Angiotensin. *Bombesin. *Calcitonin gene-related peptide. *Carnosine. *Cocaine- and amphetamine-regulated transcript ...
Kidney failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin ... enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid amide hydrolase (FAAH).[78] ... At these elevated levels, angiotensin II also constricts the afferent arteriole into the glomerulus in addition to the efferent ... "A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase". J Am Chem Soc. 135 (1): 22-25. doi ...
... position contains an amide linkage instead of the normal ester linkage of tRNA. That makes the molecule much more resistant to ...
"Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in ...
A polypeptide is a single linear chain of many amino acids (any length), held together by amide bonds. ... A decapeptide has ten amino acids (e.g., gonadotropin-releasing hormone & angiotensin I). ... Solid-phase peptide synthesis on a rink amide resin using Fmoc-α-amine-protected amino acid ... as a water molecule is released during formation of each amide bond.[4] All peptides except cyclic peptides have an N-terminal ...
"The synthesis of an octapeptide amide with the hormonal activity of oxytocin". J. Am. Chem. Soc. 75 (19): 4879-80. doi:10.1021 ... Angiotensin. *Bombesin. *Calcitonin gene-related peptide. *Carnosine. *Cocaine and amphetamine regulated transcript ...
renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor antagonists. *Renin inhibitors. *Antihyperlipidemics * ... amides. *1P-ETH-LAD. *1P-LSD. *2-Butyllysergamide. *3-Pentyllysergamide. *AL-LAD ...
regulation of blood volume by renin-angiotensin. • regulation of locomotion involved in locomotory behavior. • cellular calcium ... Peglion JL, Poitevin C, Mannoury La Cour C, Dupuis D, Millan MJ (April 2009). "Modulations of the amide function of the ... and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse". The Journal of Pharmacology and Experimental ...
... of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of ...
Blue represents a common phenolic moiety, yellow a basic nitrogen, and red a diethyl amide moiety which isn't set in stone, but ...
Angiotensin II receptor antagonist. *Endothelin receptor antagonist. *NK1 receptor antagonist. *Vasopressin receptor antagonist ...
The most important hydrogen bonds are the lactone carbonyl oxygen at C-21 to the backbone NH of Ile56, amide carbonyl at C-15 ... renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor antagonists. *Renin inhibitors. *Antihyperlipidemics * ...
Angiotensin amide definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ... A peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory ...
angiotensin amide synonyms, angiotensin amide pronunciation, angiotensin amide translation, English dictionary definition of ... angiotensin amide. n. Any of several polypeptide hormones, designated by Roman numerals, that are involved in the regulation of ... Angiotensin amide - definition of angiotensin amide by The Free Dictionary https://www.thefreedictionary.com/angiotensin+amide ... angiotensin. (redirected from angiotensin amide). Also found in: Thesaurus, Medical, Encyclopedia. an·gi·o·ten·sin. (ăn′jē-ō- ...
Angiotensinamide (INN; BAN and USAN angiotensin amide) is a potent vasoconstrictor used as a cardiac stimulant. It is a ...
... angiotensin converting enzyme), by removing a dipeptide.,/p, ,p,Angiotensin 1/2 (1-8) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro- ... angiotensin 1- 8) is yielded from angiotensin-1, a substrate of ACE ( ... Angiotensin 1/2 (1-8) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-amide) is a peptide analogue to angiotensin II that is used as ... The physiologically active peptide angiotensin-2 (angiotensin 1- 8) is yielded from angiotensin-1, a substrate of ACE ( ...
Description: Angiotensin I/II (1-7) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide) is a peptide analog to angiotensin II that is ... Description: The physiologically active peptide angiotensin-2 (angiotensin 1- 8) is yielded from angiotensin-1, a substrate of ...
The examination of synthetic valyl-5-angiotensin II-amide in the conscious dog revealed the following:. 1. Both the arterial ... 2. Angiotensin II and norepinephrine provoke a dose-dependent increase in central venous pressure. The threshold dose is about ... 3. Anesthesia and atropinization both reduce or abolish the effect of angiotensin II as well as that of norepinephrine on the ... 5. During hemorrhagic hypotension, the response to angiotensin II may be retained or even enhanced and is less likely to have ...
The important role of renin-angiotensin-aldosterone system blockade in the treatment of systemic hypertension, heart failure, ... Amides / adverse effects, chemistry, pharmacokinetics, pharmacology, therapeutic use*. Angiotensin II / blood, physiology. ... 0/Amides; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Fumarates; 0/ ... Given the established beneficial effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the ...
Calbiochem Shown to inhibit renin release in a mean arterial pressure assay with similar potency to angiotensin II amide. - ... More,, Shown to inhibit renin release in a mean arterial pressure assay with similar potency to angiotensin II amide. Less,, ... Shown to inhibit renin release in a mean arterial pressure assay with similar potency to angiotensin II amide. However, it has ... Shown to inhibit renin release in a mean arterial pressure assay with similar potency to angiotensin II amide; however, it has ...
Towards this end, four [Y]6 -Angiotensin II analogues are synthesized where amide bonds have been replaced by 1,4-disubstituted ... Renziehausen A, Eschbacher J, ONeill K, Tzakos A, Crook T, Syed Net al., 2016, ANGIOTENSIN SIGNALLING IN GBM: AT2R AS A NOVEL ... The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic ... Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity., Chemistry ...
Angiotensin amide. Anileridine; its salts. Anistreplase. Antihistamines, including substances being tetra-N-substituted ... tri-enoic acid amide, attached by the nitrogen atom and by the oxygen atom in the 15 position respectively to the 7 and 2- ...
... with angiotensin II amide the A:V ratio was 1·72 ± 0·49 (n = 35), and with synthetic human angiotensin it was 1·63 ± 0·2 (n = 6 ... similar results being obtained with angiotensin II amide and synthetic human angiotensin II. ... Arterial Angiotensin II and Venous Immunoreactive Material before and during Angiotensin Infusion in Man W. Oelkers W. Oelkers ... Characterization of Immunoreactive Angiotensin in Canine Cerebrospinal Fluid as Des-Asp 1 -Angiotensin II Clin Sci Mol Med ( ...
... ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the ... Examples of such cytostatic substance include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. ... A. Poly(ester amide) Block (A). Poly(ester amide), as used herein, encompasses any polymer having both ester and amide groups ... Novel poly(ester-amide) hot-melt adhesives. US4656242. 7 Jun 1985. 7 Apr 1987. Henkel Corporation. Poly(ester-amide) ...
Mean arterial blood pressure was elevated approximately 30 mmHg by intravenous infusion of angiotensin amide II and lowered ...
An i.a. infusion of angiotensin II amide resulted in potentiation of the response to sympathetic stimulation at a low frequency ... PATTERN OF RENAL VASOCONSTRICTION AND TRANSMITTER RELEASE DURING SYMPATHETIC STIMULATION IN PRESENCE OF ANGIOTENSIN AND COCAINE ... PATTERN OF RENAL VASOCONSTRICTION AND TRANSMITTER RELEASE DURING SYMPATHETIC STIMULATION IN PRESENCE OF ANGIOTENSIN AND COCAINE ... PATTERN OF RENAL VASOCONSTRICTION AND TRANSMITTER RELEASE DURING SYMPATHETIC STIMULATION IN PRESENCE OF ANGIOTENSIN AND COCAINE ...
Anodic Amide Oxidations: A Total Synthesis of the Angiotensin-Converting Enzyme Inhibitor A58365A. Kevin D. Moeller and Poh Lee ... The methoxylated amides were cyclized to form tricyclic amides using titanium tetrachloride. ... An anodic amide oxidation based procedure for annulating lactam rings onto amino acid derivatives has been used to construct ... Anodic amide oxidations in the presence of electron-rich phenyl rings: evidence for an intramolecular electron-transfer ...
CONCLUSIONS:Angiotensin-II production appears to be associated with elevated levels of reactive oxygen species, but Ang-II ... The aim of this study was to investigate the effects of pharmacological inhibition of angiotensin-II (Ang-II) production on ... Keywords: Angiotensin-Converting Enzyme Inhibitors - pharmacology, Angiotensin II - metabolism, Amides - pharmacology, Animals ... CONCLUSIONS: Angiotensin-II production appears to be associated with elevated levels of reactive oxygen species, but Ang-II ...
... and methods of using these compounds to produce angiotensin II receptor antagonism in mammals. ... Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the ... N-aroylamino acid amides as endothelin inhibitors US6090828A (en) 2000-07-18. 5-aryleheteroarylalkyl-1,3,5-trisubstituted-1,2,4 ... Angiotensin II receptor blocking benzimidazoles US5399566A (en) 1995-03-21. Pyridine derivatives having angiotensin II ...
Examples of such cytostatic substance include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. ... A. Poly(Ester Amide) Block (A). Poly(ester amide), as used herein, encompasses any polymer having both ester and amide groups ... Poly(Ester Amide) Block Copolymer. In one aspect of the present invention, provided herein is a copolymer that includes a soft ... Synthesis and Study of Regular Poly(ester amide)s Based on Bis(.alpha./amino acid).alpha.,.omega./Alkylene Diesters, and ...
Angiotensin 1/2 (1-8) amide. A1055-1 ApexBio 1 mg. EUR 96 ... is yielded from angiotensin-1, a substrate of ACE (angiotensin ... Description: The physiologically active peptide angiotensin-2 (angiotensin 1- 8) ... and selective angiotensin II type 1 receptor (AT1) antagonist. ...
Description: Angiotensin I/II (1-7) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide) is a peptide analog to angiotensin II that is ... Description: The physiologically active peptide angiotensin-2 (angiotensin 1- 8) is yielded from angiotensin-1, a substrate of ... and selective angiotensin II type 1 receptor (AT1) antagonist. ...
Description: Angiotensin I/II (1-7) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide) is a peptide analog to angiotensin II that is ... Description: The physiologically active peptide angiotensin-2 (angiotensin 1- 8) is yielded from angiotensin-1, a substrate of ... and selective angiotensin II type 1 receptor (AT1) antagonist. ...
Amides / therapeutic use* * Angiotensin-Converting Enzyme Inhibitors / adverse effects * Angiotensin-Converting Enzyme ...
Similarly, infusion of angiotensin II amide led to a significantly increased ipsilateral excretion rate of prostaglandin E2 and ... In man, i.v. infusion of angiotensin also led to an increased urinary eliminiation of prostaglandin E. These results show that ... These studies indicate that there is a close correlation of bradykinin levels with renin activity and angiotensin II, in both ... The possibility that bradykinin, a potent vasodilator, might be a physiological antagonist of the renin-angiotensin system was ...
Implantable medical devices including a coating having a bioactive agent and a poly(ester amide) polymer. Methods of forming ... Examples of cytostatic substances include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. Capoten ... Unsaturated poly(ester-amide) biomaterials US20050271700A1 (en) 2004-06-03. 2005-12-08. Desnoyer Jessica R. Poly(ester amide) ... Poly(ester-amide) and poly(amide) coatings for implantable medical devices for controlled release of a protein or peptide and a ...
Al-Merani SA, Brooks DP, Chapman BJ, Munday KA: The half-lives of angiotensin II, angiotensin II-amide, angiotensin III, Sar1- ... p53 enhances the myocyte renin-angiotensin system (RAS) and the formation of angiotensin II (Ang II). Moreover, p53 reduces the ... Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor ... Yamada T, Horiuchi M, Dzau VJ: Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci U S A 93:156- ...
angiotensin. *angiotensin amide. *angiotensin i. *angiotensin ii. Browse the Dictionary. :*#. *A. *B ...
Angiotensin Amide - metabolism , Animals , Biological Ontologies , Humans , Angiotensin Amide - genetics , Databases, Genetic ... angiotensin amide - genetics (1) 1 Filter by. Remove filter. angiotensin amide - metabolism (1) 1 ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Amides (pharmacology, therapeutic use) *Angiotensin II (pharmacology) *Animals. *Antihypertensive Agents (pharmacology, ... angiotensin II)-dependent forms of hypertension and the associated target organ damage. The present studies were performed in ...
  • A peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse. (dictionary.com)
  • The physiologically active peptide angiotensin-2 (angiotensin 1- 8) is yielded from angiotensin-1, a substrate of ACE (angiotensin converting enzyme), by removing a dipeptide. (apexbt.com)
  • Angiotensin 1/2 (1-8) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-amide) is a peptide analogue to angiotensin II that is used as a vasopressor agent in the treatment of certain types of shock and circulatory collapse. (apexbt.com)
  • 6. It is proposed that arterial PAC rather than venous IM should be measured when the relationship between blood levels and biological effects of the peptide are the object of the study, particularly during angiotensin infusion or when rapid changes in circulating angiotensin occur. (portlandpress.com)
  • 2. An absorbable stent formed of a material comprising a copolymer, wherein the copolymer comprises a poly(ester amide) block and a tyrosine di-peptide block. (google.com.au)
  • In vivo both domains clear the vasodilator peptide bradykinin with approximately equal efficiencies [ 7 - 9 ], the C-domain appears to be the prominent site for the production of vasoactive peptide angiotensin II, whereas the N-domain is the primary site for the clearance of tetrapeptide Ac-SDKP ( N -acetyl-Ser-Asp-Lys-Pro) [ 8 - 10 ]. (clinsci.org)
  • Angiotensin , a peptide , one form of which, angiotensin II, causes constriction of blood vessels . (britannica.com)
  • Peptide molecules are composed of two or more amino acids joined through amide formation involving the carboxyl group of each amino acid and the amino group of the next. (britannica.com)
  • The chemical bond between the carbon and nitrogen atoms of each amide group is called a peptide bond . (britannica.com)
  • BAN and USAN angiotensin amide) is a potent vasoconstrictor used as a cardiac stimulant. (wikipedia.org)
  • Amide as vasoconstrictor. (druglead.com)
  • Procaine amide reduced the reflex vasoconstrictor response to carotid hypotension, but this reduction was comparable to the inhibition of sympathetic ganglionic transmission. (ahajournals.org)
  • Angiotensin II is well known as a potent vasoconstrictor, but many reports indicate that angiotensins exert vasodilator properties. (ahajournals.org)
  • Cross-tachyphylaxis can be demonstrated between renin and angiotensin II but not between either of these and norepinephrine. (ahajournals.org)
  • These results suggest that tachyphylaxis to renin is due to tachyphylaxis to angiotensin. (ahajournals.org)
  • Shown to inhibit renin release in a mean arterial pressure assay with similar potency to angiotensin II amide. (emdmillipore.com)
  • The important role of renin-angiotensin-aldosterone system blockade in the treatment of systemic hypertension, heart failure, diabetic kidney disease, and atherogenesis has been clearly established. (biomedsearch.com)
  • The theoretical therapeutic advantages for inhibiting the detrimental effects of the renin-angiotensin system at its most upstream point have served as the impetus for the development of renin inhibitors. (biomedsearch.com)
  • The advent of aliskiren, the first in a novel class of orally active, nonpeptide, highly specific, human renin inhibitors, provides a new modality in the armamentarium of renin-angiotensin system antagonists. (biomedsearch.com)
  • Studies in marmosets and rats demonstrated that aliskiren reduced blood pressure in a dose-dependent manner and is highly efficacious in blocking plasma renin activity with parallel reductions in the levels of the other downstream constituents of the renin-angiotensin system. (biomedsearch.com)
  • Response of the kallikrein-kinin and renin-angiotensin systems to saline infusion and upright posture. (jci.org)
  • To determine whether enzymatic p53 glycosylation leads to angiotensin II formation followed by p53 phosphorylation, prolonged activation of the renin-angiotensin system, and apoptosis, ventricular myocytes were exposed to levels of glucose mimicking diabetic hyperglycemia. (diabetesjournals.org)
  • In conclusion, these in vitro results support the notion that hyperglycemia with diabetes promotes myocyte apoptosis mediated by activation of p53 and effector responses involving the local renin-angiotensin system. (diabetesjournals.org)
  • Because p53 binding sites are present in the promoter of angiotensinogen (Aogen) and AT 1 receptor genes ( 11 , 12 ), p53 enhances the myocyte renin-angiotensin system (RAS) and the formation of angiotensin II (Ang II). (diabetesjournals.org)
  • The enzymatic action of renin acts on angiotensinogen to form the decapeptide angiotensin I, which is relatively inactive. (thefreedictionary.com)
  • ACE inhibitors, such as captopril , are antagonists of the renin-angiotensin-aldosterone system and potentiators of the kinin system and are used for treatment of hypertension, usually in conjunction with a diuretic. (thefreedictionary.com)
  • See Renin/angiotensin/aldosterone system. (thefreedictionary.com)
  • The chapters provide insights gained by the genetic manipulation of angiotensin II, assessment of its transcriptional and translational regulation, work on the angiotensin receptors , the status of the specific molecular components of the renin-angiotensin-aldosterone system under differing conditions, and functional responses to the angiotensins. (thefreedictionary.com)
  • Due to its critical role in the Renin-Angiotensin-Aldosterone System (RAAS), ACE has been targeted by a number of pharmaceutical compounds to treat hypertension, diabetic nephropathy, and renal failure. (proteopedia.org)
  • [3] The Renin-Angiotensin System (RAS) is a major regulator of blood pressure in the human body. (proteopedia.org)
  • Renin is an enzyme produced by the liver which cleaves Angiotensinogen into Angiotensin I Angiotensin Ihas the sequence, DRVTIHPFHL, and does not appear to have any biological activity. (proteopedia.org)
  • See the schematic image of the Renin-Angiotensin-Aldosterone System at the left for a visual description and the table below for selected Angiotensin receptor-mediated effects of binding Angiotensin II. (proteopedia.org)
  • The authors investigated the long-term effectiveness and safety of aliskiren (ALIS) with particular attention on its association with dual blockade of the renin-angiotensin system (RAS). (mdc-berlin.de)
  • Angiotensin I is produced by the action of renin (an enzyme produced by the kidneys ) on a protein called angiotensinogen, which is formed by the liver . (britannica.com)
  • Obesity-associated arterial hypertension is characterised by activation of the sympathetic system, activation of the renin-angiotensin system, and sodium retention, among different abnormalities. (conferenceseries.com)
  • Recent evidence of interactions between the renin-angiotensin system and the endocannabinoid system suggests that anandamide and 2-arachidonoylglycerol may modulate Ang II contraction. (mdc-berlin.de)
  • These renin-angiotensin system-endocannabinoid system interactions may contribute to the enhanced vascular reactivity in early stages of hypertensive pregnancy. (mdc-berlin.de)
  • ACE has long been known to be a key part of the renin angiotensin system that regulates blood pressure, and ACE inhibitors are important for the treatment of hypertension. (biomedcentral.com)
  • 2. In the present study, we compared the effects of aliskiren (10 mg/kg per day), the angiotensin-converting enzyme inhibitor perindopril (0.2 mg/kg per day) and their combination on angiotensin and bradykinin peptides in female heterozygous (mRen-2)27 rats, transgenic for the mouse renin gene. (edu.au)
  • A hydrolase responsible for the conversion of angiotensin I to the vasoactive angiotensin II by removal of a dipeptide (histidylleucine) from angiotensin I. Drugs that inhibit ACE are used to treat hypertension and congestive heart failure. (thefreedictionary.com)
  • Angiotensin infusion test in the diagnosis of renal hypertension. (bvsalud.org)
  • Drugs that inhibit ACE, and thus block the conversion of angiotensin I to angiotensin II, are used to lower blood pressure in patients with hypertension . (britannica.com)
  • Given the established beneficial effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the treatment of cardiovascular and renovascular diseases, future studies may further elucidate a similar protective role for aliskiren both as a monotherapy and as part of a combination therapy. (biomedsearch.com)
  • angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme , which converts angiotensin I to angiotensin II and inactivates bradykinin. (thefreedictionary.com)
  • The open, prospective 3A Registry (N=8723) in Germany assigned patients in a 4:1:1 ratio to ALIS, angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs), or non-RAS drugs. (mdc-berlin.de)
  • Cell-surface G-protein-coupled receptors that mediate the effects of angiotensin II. (thefreedictionary.com)
  • Drugs that block the angiotensin receptors , (AT1R blockers) are prescribed to millions of people to lower high blood pressure. (thefreedictionary.com)
  • Further, Angiotensin II binds to kidney AT1 receptors resulting in sodium ion reabsorption, leading to increased water retention in the blood and subsequent increased blood pressure. (proteopedia.org)
  • Other studies indicate that angiotensin AT 2 receptors might mediate a depressor action, and the present study was designed to delineate and explore this possibility in a conscious rabbit model. (ahajournals.org)
  • It is clear that specific angiotensin IV or angiotensin-(1-7) receptors do not mediate depressor effects in this model. (ahajournals.org)
  • The data obtained with the angiotensin receptor subtype-selective compounds, losartan and PD 123319, suggest that the depressor action is an AT 1 -mediated effect and give no indication that AT 2 receptors could be involved. (ahajournals.org)
  • Paradoxically, the greater potency of angiotensin III as a vasodepressor belies the conclusion that the response is AT 1 -mediated, because AT 1 receptors have a greater affinity for angiotensin II versus angiotensin III. (ahajournals.org)
  • Angiotensin III was a more potent depressor than was angiotensin II, and this is consistent with an AT 2 -mediated response because angiotensin III binds less effectively than angiotensin II at AT 1 receptors but has a comparable affinity at AT 2 receptors. (ahajournals.org)
  • des-Asp angiotensin I attenuated the contractile responses to angiotensin III but potentiated the response to angiotensin II, and the authors state that the 2 peptides exert their effects at 2 different receptors. (ahajournals.org)
  • 5 Our experiments were designed to test the hypothesis that the depressor response is mediated by AT 2 receptors and that depressor responses to angiotensin III will be more prominent than those produced by angiotensin II. (ahajournals.org)
  • Our experiments also address the hypothesis that angiotensinogenic depressor responses could be mediated by non-AT 1 /AT 2 receptors, because of the experiments by Haberl 6 described above and the observation that angiotensin IV and angiotensin-(1-7) have dilator or depressor activity. (ahajournals.org)
  • Blood pressure also can be lowered using drugs that are designed to block the receptors to which angiotensin II must bind to exert its actions. (britannica.com)
  • In a handful of young blacks identified as sodium retainers through a complex research protocol, Harshfield has shown that the dangerous sodium load can be lifted with angiotensin receptor blockers , a common blood pressure treatment. (thefreedictionary.com)
  • We determined the role of the cannabinoid receptor 1 by blockade with SR171416A, and the contribution of anandamide and 2-arachidonoylglycerol degradation to Ang II contraction by inhibiting their hydrolyzing enzyme fatty acid amide hydrolase (with URB597) or monoacylglycerol lipase (with JZL184), respectively. (mdc-berlin.de)
  • Fatty acid amide hydrolase blockade decreased Ang IIMAX in Sprague-Dawley UA, and decreased both Ang IIMAX and sensitivity in TgA UA. (mdc-berlin.de)
  • fatty acid amide hydrolase predominantly localized in endothelium and monoacylglycerol lipase in smooth muscle cells. (mdc-berlin.de)
  • The aim of this study was to investigate the effects of pharmacological inhibition of angiotensin-II (Ang-II) production on heart tissue with ischemia-reperfusion damage, arrhythmia, and oxidative stress. (medscimonit.com)
  • Inhibition of O-glycosylation prevented the initial synthesis of angiotensin II, p53, and p38-MAP kinase (MAPK) phosphorylation and apoptosis. (diabetesjournals.org)
  • Inhibition of sympathetic ganglionic transmission contributed predominantly to the vasodilatation in muscle that accompanied intravenous administration of procaine amide (20 mg/kg). (ahajournals.org)
  • in both muscle and paw, no decreases in base-line perfusion pressures and no inhibition of constrictor responses to phenylephrine, angiotensin, and 5-hydroxytryptamine occurred. (ahajournals.org)
  • We conclude that the vasodilator effect of procaine amide results from inhibition of ganglionic transmission. (ahajournals.org)
  • 4. In endotoxin hypotension, the pressor response to angiotensin II and to norepinephrine is diminished, and the venous pressure response becomes gradually depressed until it is completely abolished. (ahajournals.org)
  • Early in vitro work showed vasorelaxation by angiotensins in some vascular beds, 1 2 3 and Campbell et al 4 reported a vasodepressor phase after the characteristic pressor response to angiotensin II in conscious rabbits. (ahajournals.org)
  • [1] ACE is a zinc- and chloride-dependent metallopeptidase that is responsible for the metabolism of key biologically active peptides, namely Angiotensin I and Bradykinin. (proteopedia.org)
  • Based on potential proteolytic cleavage sites, three C-terminal hypothetical peptides are predicted: Phoenixin-20 amide, Phoenixin15 (Phoenixin-14-Gly), and Phoenixin-14 amide. (phoenixpeptide.com)
  • Vasodilatation by angiotensins in the cerebral circulation might occur by different mechanisms, in view of the fact that it appears to be blocked by both AT 1 and AT 2 antagonists and seems to be similar to arginine-induced vasodilatation. (ahajournals.org)
  • 4-Diazinyl- and 4-Pyridinylimidazoles: Potent Angiotensin II Antagonists. (patentgenius.com)
  • It in turn is acted upon by peptidases (converting enzymes), chiefly in the lungs, to form the octapeptide angiotensin II, a powerful vasopressor and a stimulator of aldosterone secretion by the adrenal cortex. (thefreedictionary.com)
  • [5] Binding of Angiotensin II to ATI leads to vasoconstriction by vascular smooth muscle cells, resulting in increased blood pressure, as well as the release of fluid and electrolyte homeostasis regulator, aldosterone, by the adrenal glands. (proteopedia.org)
  • 3. All three treatments produced similar reductions in systolic blood pressure, heart weight and plasma aldosterone levels and reduced angiotensin II levels in lung, but only perindopril and the combination reduced angiotensin II levels in kidney of (mRen-2)27 rats. (edu.au)
  • Conclusions: PAR2-mediated vasodilatation of resistance type arteries is protected against the negative effects of angiotensin II-induced vascular dysfunction in mice. (mun.ca)
  • Abstract -Vasodilator and vasodepressor properties of angiotensins have been reported, and mediation by prostaglandins or nitric oxide has been proposed. (ahajournals.org)
  • abstract = "The interactions of angiotensin II and a synthetic analogue, [Asn1, Val5] angiotensin II, with Ca2+ and Tb3+ have been monitored using the intrinsic fluorescence of the tyrosine residue at position 4 in both molecules. (elsevier.com)
  • Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. (google.com.au)
  • This invention generally relates to poly(ester amide) block copolymers useful for forming a bioabsorbable device such as a stent or for coating an implantable device such as a drug-delivery stent. (google.com.au)
  • ACE catalyzes the conversion of the decapeptide Angiotensin I to the octapeptide Angiotensin II. (proteopedia.org)
  • Angiotensin-I-converting enzyme (ACE) is a monomeric, membrane-bound, zinc- and chloride-dependent peptidyl dipeptidase that catalyzes the conversion of the decapeptide angiotensin I to the octapeptide angiotensin II, by removing a carboxy-terminal dipeptide. (biomedcentral.com)
  • Angiotensin-I-converting enzyme (ACE, also known as peptidyl-dipeptidase A or kininase II) was first isolated in 1956 and shown to be a chloride-dependent metalloenzyme that cleaves a dipeptide from the carboxyl terminus of the decapeptide angiotensin I to form the potent vasopressor (blood vessel constrictor) angiotensin II [ 1 ]. (biomedcentral.com)
  • The octapeptide angiotensin II differs among species only in the amino acid residue in position 5 being either Val or Ile. (druglead.com)
  • Synthesis and Study of Regular Poly(ester amide)s Based on Bis(.alpha. (patentgenius.com)
  • Angiotensin II synthesis increased at 45 min and 1 h, resulting in p38 mitogen-activated protein (MAP) kinase-driven p53 phosphorylation at Ser 390. (diabetesjournals.org)
  • Soulakis2, D. Mourelatos1, E. Mioglou1, 1 Laboratory of General Biology and Genetics, Aristotle University of Thessaloniki 2 Laboratory of Pharmaceutical Chemistry, University of Patras The reasons for the synthesis of the compounds studied in the present work are a) The already known antineoplastic activity of Hecogenin in HeLa cells and b) the knowledge that the amide (-NHCO-) group in modified steroidal derivatives of Chlorambucil enhances the. (centrallakesclinic.biz)
  • 1. Angiotensin II together with any immunoreactive fragments of angiotensin were measured in arterial and venous plasma before and during infusion of angiotensin II amide in five normotensive subjects, both in sodium-replete and sodium-depleted states. (portlandpress.com)
  • 2. Arterial plasma angiotensin II concentration (PAC) and venous IM were compared in two additional subjects during infusion of angiotensin II amide and of synthetic human angiotensin II. (portlandpress.com)
  • 5. Results of an in vitro study suggest that the formation of new angiotensin in the vein is not sufficient to explain the lower A:V ratio of PAC before infusion. (portlandpress.com)
  • Mean arterial blood pressure was elevated approximately 30 mmHg by intravenous infusion of angiotensin amide II and lowered about 10 mmHg by intravenous infusion of trimethaphan camsylate. (nih.gov)
  • An i.a. infusion of angiotensin II amide resulted in potentiation of the response to sympathetic stimulation at a low frequency (2 cps) and an increased release of catecholamine elicited during stimulation at a higher frequency (5 cps). (aspetjournals.org)
  • A zinc-containing hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine (an important step in the metabolism of certain vasopressor agents). (thefreedictionary.com)
  • Angiotensin-converting enzyme (ACE) catalyses the conversion of Ang I to Ang II and degrades bradykinin 1-9 (BK2 receptor agonist). (diabetesaid.com)
  • Moreover, 3 mg/kg per day aliskiren increased cardiac bradykinin levels, but did not reduce renal angiotensin levels. (edu.au)
  • Upregulation of p53 was associated with an accumulation of angiotensinogen and AT 1 and enhanced production of angiotensin II. (diabetesjournals.org)
  • These compounds inhibit the action of angiotensin II and therefore useful, for example, as protivogipertonicheskoe funds. (russianpatents.com)
  • Described new compounds that inhibit the action of the hormone angiotensin II. (russianpatents.com)
  • 2. Angiotensin II and norepinephrine provoke a dose-dependent increase in central venous pressure. (ahajournals.org)
  • In doses eliciting the same increase of arterial blood pressure, norepinephrine is about twice as active on the venous pressure as angiotensin II. (ahajournals.org)
  • 3. Anesthesia and atropinization both reduce or abolish the effect of angiotensin II as well as that of norepinephrine on the venous pressure, indicating the reflex nature of the underlying mechanism. (ahajournals.org)
  • 5. During hemorrhagic hypotension, the response to angiotensin II may be retained or even enhanced and is less likely to have an adverse effect on the myocardium than norepinephrine. (ahajournals.org)
  • 1. Both the arterial and the central venous pressure responses exhibit tachyplylaxis when high doses of angiotensin II are administered, althoug not when medium or low doses are given. (ahajournals.org)
  • Also, procaine amide had no detectable effects on constrictor responses to stimulation of sympathetic postganglionic nerves. (ahajournals.org)
  • The absence of direct inhibitory effects on baroreceptors and central reflex pathways was supported by the failure of intracarotid administration of procaine amide to alter detectably in gracilis muscle base-line perfusion pressures and reflex constrictor responses to carotid hypotension. (ahajournals.org)
  • Procaine amide reduced reflex responses to carotid chemoreceptor stimulation with nicotine but not those to stimulation with cyanide, suggesting a direct selective inhibitory action on the carotid body but not on the central pathways of the reflex. (ahajournals.org)
  • Large intravenous boluses of angiotensin III (15 nmol/kg) produced a predictable pressor peak (82±4 mm Hg) followed by a depressor phase (20±3 mm Hg), whereas equipressor doses of angiotensin II were less effective at producing depressor responses. (ahajournals.org)
  • 5 Depressor or dilator responses to angiotensins are not duplicated by other vasopressors, tend to be manifested at high angiotensin concentrations, and might be prominent in specific vascular beds. (ahajournals.org)
  • 11 An AT 2 -mediated dilator action is further supported by a study of Li et al, 12 who reported that angiotensin III contractile responses in rat aorta were accentuated by PD 123177 but that angiotensin II and IV responses were unaffected. (ahajournals.org)
  • We compared the vasodilatation of resistance-type arteries (mesenteric) from angiotensin II-treated PAR2 wild-type mice (WT) induced by PAR2 agonist 2-furoyl-LIGRLO-amide (2fly) to the responses obtained in controls (saline treatment). (mun.ca)
  • The data indicate that angiotensin II binds both metals with a dissociation constant of ∼1 × 10 -4 M -1 , while no significant binding was observed with the amide analogue. (elsevier.com)
  • An anodic amide oxidation based procedure for annulating lactam rings onto amino acid derivatives has been used to construct the angiotensin-converting enzyme inhibitor A58365A. (wustl.edu)
  • The angiotensin-inactivating capacity of homogenates prepared from kidneys of rats subjected to various experimental procedures was studied. (naver.com)
  • Angiotensin II is hydrolyzed in various tissues to form heptapeptide angiotensin III, which has less vasopressor activity but more effect on the adrenal cortex. (thefreedictionary.com)
  • Increased vascular sensitivity to angiotensin II (Ang II) is a marker of a hypertensive human pregnancy. (mdc-berlin.de)
  • losartan also prevented phosphorylation of p38-MAPK by angiotensin II. (diabetesjournals.org)
  • The AT 1 antagonist losartan (1 mg/kg) blocked both the pressor and depressor components of the angiotensin III response, whereas the AT 2 antagonist PD 123319 (35 mg/kg) had no effect on either element of the response. (ahajournals.org)
  • The VA NEPHRON-D (Veterans Affairs Nephropathy in Diabetes) study involved 1,448 patients with type 2 diabetes and moderate diabetic nephropathy who were treated for at least 30 days with 100 mg daily of the angiotensin receptor blocker (ARB) losartan, as is standard practice in patients with diabetes. (thefreedictionary.com)
  • 15. The medical device of claim 1, wherein the polymer comprises a poly(ester amide) polymer. (patentsencyclopedia.com)
  • Angiotensin-(1-7) did not exert a depressor action, and the reduced potency of angiotensin IV (relative to angiotensin III) was similar for both the pressor and depressor phases (≈100-fold). (ahajournals.org)
  • Because the antibody used in the radioimmunoassay cross-reacted with larger angiotensin breakdown products and because these fragments are present in higher concentrations in venous than arterial plasma, samples of both were assayed. (portlandpress.com)
  • 3. Arterial PAC and venous IM increased in linear relation to the dose of angiotensin infused, similar results being obtained with angiotensin II amide and synthetic human angiotensin II. (portlandpress.com)
  • The mechanism of the vasodilator effect of procaine amide in dogs was investigated in isolated gracilis muscle and hindpaw perfused at constant flows with arterial blood. (ahajournals.org)
  • We also investigated arterial vasodilatation in angiotensin IItreated PAR2 deficient (PAR2-/-) mice. (mun.ca)
  • Alternatively, the seven-membered ring lactams were obtained without rearrangement when electron withdrawing groups were present beta to the amide carbonyl. (wustl.edu)
  • The fact that energy transfer was observed between Tb 3+ and the tyrosine of angiotensin places the hydroxl or carbonyl group of the tyrosine close to the metal binding site. (elsevier.com)
  • with angiotensin II amide the A:V ratio was 1·72 ± 0·49 ( n = 35), and with synthetic human angiotensin it was 1·63 ± 0·2 ( n = 6). (portlandpress.com)
  • The synthetic route described utilizes an electrochemical amide oxidation to functionalize a proline derivative, and then a sequential cyclization-rearrangement strategy to construct a substituted six-membered ring lactam. (wustl.edu)
  • The interactions of angiotensin II and a synthetic analogue, [Asn 1 , Val 5 ] angiotensin II, with Ca 2+ and Tb 3+ have been monitored using the intrinsic fluorescence of the tyrosine residue at position 4 in both molecules. (elsevier.com)
  • Angiotensin II acts directly on blood vessels, causing their constriction and thereby raising blood pressure . (britannica.com)
  • The difference in the relative degree of potentiation of the response to endogenously released vs. exogenously administered catecholamine, and the characteristics of the potentiated response at the lower frequency after angiotensin, suggest that this potentiation is accounted for by a mechanism different from blockade of reuptake of the transmitter. (aspetjournals.org)
  • a glycoprotein (dipeptidyl carboxypeptidase) that catalyzes the conversion of angiotensin I to angiotensin II by splitting two terminal amino acids. (thefreedictionary.com)
  • The substance so formed is a decapeptide called angiotensin I which is converted to the active pressor agent, angiotensin II , by the splitting off of the C- terminal His-Leu residues by the angiotensin converting enzyme (ACE) or angiotensinase . (druglead.com)