Angiostatins: Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. 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Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Rectal Neoplasms: Tumors or cancer of the RECTUM.Lung Neoplasms: Tumors or cancer of the LUNG.Peer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. 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(From ALA Glossary of Library and Information Science, 1983, p181)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.PubMed: A bibliographic database that includes MEDLINE as its primary subset. 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When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Palatal Expansion Technique: An orthodontic method used for correcting narrow or collapsed maxillary arches and functional cross-bite. (From Jablonski's Dictionary of Dentistry),Friction: Surface resistance to the relative motion of one body against the rubbing, sliding, rolling, or flowing of another with which it is in contact.Blood Vessels: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).Posture: The position or attitude of the body.Endovascular Procedures: Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Vascular Patency: The degree to which BLOOD VESSELS are not blocked or obstructed.Lung Diseases, Obstructive: Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Forced Expiratory Volume: Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.Urogenital Neoplasms: Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.Access to Information: Individual's rights to obtain and use information collected or generated by others.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Fagopyrum: A plant genus of the family POLYGONACEAE that is used as an EDIBLE GRAIN. Although the seeds are used as cereal, the plant is not one of the cereal grasses (POACEAE).Bunion, Tailor's: Abnormal swelling of the outer aspect of the fifth metatarsal head affecting the fifth METATARSOPHALANGEAL JOINT.Medical Staff: Professional medical personnel who provide care to patients in an organized facility, institution or agency.Research Support as Topic: Financial support of research activities.
Angiostatin binds ATP synthase on the surface of human endothelial cells. (1/210)
Angiostatin, a proteolytic fragment of plasminogen, is a potent antagonist of angiogenesis and an inhibitor of endothelial cell migration and proliferation. To determine whether the mechanism by which angiostatin inhibits endothelial cell migration and/or proliferation involves binding to cell surface plasminogen receptors, we isolated the binding proteins for plasminogen and angiostatin from human umbilical vein endothelial cells. Binding studies demonstrated that plasminogen and angiostatin bound in a concentration-dependent, saturable manner. Plasminogen binding was unaffected by a 100-fold molar excess of angiostatin, indicating the presence of a distinct angiostatin binding site. This finding was confirmed by ligand blot analysis of isolated human umbilical vein endothelial cell plasma membrane fractions, which demonstrated that plasminogen bound to a 44-kDa protein, whereas angiostatin bound to a 55-kDa species. Amino-terminal sequencing coupled with peptide mass fingerprinting and immunologic analyses identified the plasminogen binding protein as annexin II and the angiostatin binding protein as the alpha/beta-subunits of ATP synthase. The presence of this protein on the cell surface was confirmed by flow cytometry and immunofluorescence analysis. Angiostatin also bound to the recombinant alpha-subunit of human ATP synthase, and this binding was not inhibited by a 2,500-fold molar excess of plasminogen. Angiostatin's antiproliferative effect on endothelial cells was inhibited by as much as 90% in the presence of anti-alpha-subunit ATP synthase antibody. Binding of angiostatin to the alpha/beta-subunits of ATP synthase on the cell surface may mediate its antiangiogenic effects and the down-regulation of endothelial cell proliferation and migration. (+info)Angiostatin formation involves disulfide bond reduction and proteolysis in kringle 5 of plasmin. (2/210)
Plasmin is processed in the conditioned medium of HT1080 fibrosarcoma cells producing fragments with the domain structures of the angiogenesis inhibitor, angiostatin, and microplasmin. Angiostatin consists of kringle domains 1-4 and part of kringle 5, while microplasmin consists of the remainder of kringle 5 and the serine proteinase domain. Our findings indicate that formation of angiostatin/microplasmin involves reduction of plasmin by a plasmin reductase followed by proteolysis of the reduced enzyme. We present evidence that the Cys461-Cys540 and Cys511-Cys535 disulfide bonds in kringle 5 of plasmin were reduced by plasmin reductase. Plasmin reductase activity was secreted by HT1080 and Chinese hamster ovary cells and the human mammary carcinoma cell lines MCF-7, MDA231, and BT20 but not by the monocyte/macrophage cell line THP-1. Neither primary foreskin fibroblasts, blood monocyte/macrophages, nor macrovascular or microvascular endothelial cells secreted detectable plasmin reductase. In contrast, cultured bovine and rat vascular smooth muscle cells secreted small but reproducible levels of plasmin reductase. Reduction of the kringle 5 disulfide bonds triggered cleavage at either Arg529-Lys530 or two other positions C-terminal of Cys461 in kringle 5 by a serine proteinase. Plasmin autoproteolysis could account for the cleavage, although another proteinase was mostly responsible in HT1080 conditioned medium. Three serine proteinases with apparent Mr of 70, 50, and 39 were purified from HT1080 conditioned medium, one or more of which could contribute to proteolysis of reduced plasmin. (+info)Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. (3/210)
Solid tumors depend on angiogenesis for their growth. In a transgenic mouse model of pancreatic islet cell carcinogenesis (RIP1-Tag2), an angiogenic switch occurs in premalignant lesions, and angiogenesis persists during progression to expansive solid tumors and invasive carcinomas. RIP1-Tag2 mice were treated so as to compare the effects of four angiogenesis inhibitors at three distinct stages of disease progression. AGM-1470, angiostatin, BB-94, and endostatin each produced distinct efficacy profiles in trials aimed at preventing the angiogenic switch in premalignant lesions, intervening in the rapid expansion of small tumors, or inducing the regression of large end-stage cancers. Thus, anti-angiogenic drugs may prove most efficacious when they are targeted to specific stages of cancer. (+info)Systemic gene delivery expands the repertoire of effective antiangiogenic agents. (4/210)
Cationic liposome-DNA complex (CLDC)-based intravenous gene delivery targets gene expression to vascular endothelial cells, macrophages and tumor cells. We used systemic gene delivery to identify anti-angiogenic gene products effective against metastatic spread in tumor-bearing mice. Specifically, CLDC-based intravenous delivery of the p53 and GM-CSF genes were each as effective as the potent antiangiogenic gene, angiostatin, in reducing both tumor metastasis and tumor angiogenesis. Combined delivery of these genes did not increase anti-tumor activity, further suggesting that each gene appeared to produce its antimetastatic activity through a common antiangiogenic pathway. CLDC-based intravenous delivery of the human wild type p53 gene transfected up to 80% of tumor cells metastatic to lung. Furthermore, it specifically induced the expression of the potent antiangiogenic gene, thrombospondin-1, indicating that p53 gene delivery in vivo may inhibit angiogenesis by inducing endogenous thrombospondin-1 expression. CLDC-based delivery also identified a novel anti-tumor activity for the metastasis suppressor gene CC3. Thus, CLDC-based intravenous gene delivery can produce systemic antiangiogenic gene therapy using a variety of different genes and may be used to assess potential synergy of combined anti-tumor gene delivery and to identify novel activities for existing anti-tumor genes. (+info)Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation. (5/210)
Angiostatin, a kringle-containing fragment of plasminogen, is a potent inhibitor of angiogenesis. The mechanism(s) responsible for the anti-angiogenic properties of angiostatin are unknown. We now report that human angiostatin blocks plasmin(ogen)-enhanced in vitro invasion of tissue plasminogen activator (t-PA)-producing endothelial and melanoma cells. Kinetic analyses demonstrated that angiostatin functions as a non-competitive inhibitor of extracellular-matrix (ECM)-enhanced, t-PA-catalysed plasminogen activation, with a Ki of 0.9+/-0.03 microM. This mechanism suggests that t-PA has a binding site for the inhibitor angiostatin, as well as for its substrate plasminogen that, when occupied, prevents ternary complex formation between t-PA, plasminogen and matrix protein. Direct binding experiments confirmed that angiostatin bound to t-PA with an apparent Kd [Kd(app)] of 6.7+/-0.7 nM, but did not bind with high affinity to ECM proteins. Together, these data suggest that angiostatin in the cellular micro-environment can inhibit matrix-enhanced plasminogen activation, resulting in reduced invasive activity, and suggest a biochemical mechanism whereby angiostatin-mediated regulation of plasmin formation could influence cellular migration and invasion. (+info)Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. (6/210)
Proteolytic enzymes are involved in generation of a number of endogenous angiogenesis inhibitors. Previously, we reported that angiostatin, a potent angiogenesis inhibitor, is a proteolytic fragment containing the first four kringle modules of plasminogen. In this report, we demonstrate that urokinase-activated plasmin can process plasminogen to release an angiogenesis inhibitor, K1-5 (protease-activated kringles 1-5). K1-5 inhibits endothelial-cell proliferation with a half-maximal concentration of approximately 50 pM. This inhibitory effect is endothelial-cell-specific and appears to be at least approximately 50-fold greater than that of angiostatin. A synergistic efficacy of endothelial inhibition was observed when angiostatin and kringle 5 (K5) were coincubated with capillary endothelial cells. The synergistic effect is comparable to that produced by K1-5 alone. Systemic treatment of mice with K1-5 at a low dose significantly blocked the fibroblast growth factor-induced corneal neovascularization, whereas angiostatin had no effect at the same dose. K1-5 also suppressed angiogenesis in chicken embryos. Systemic administration of K1-5 at a low dose at which angiostatin was ineffective significantly suppressed the growth of a murine T241 fibrosarcoma in mice. The antitumor effect correlates with the reduced neovascularization. These findings suggest that the plasmin-mediated proteolysis may be involved in the negative switch of angiogenesis. (+info)Therapeutic potentials of angiostatin in the treatment of cancer. (7/210)
The discovery of specific endothelial inhibitors such as angiostatin and endostatin not only increases our understanding of the functions of these molecules in the regulation of physiological and pathological angiogenesis, but also provides an important therapeutic strategy for cancer treatment. Recent studies have demonstrated that the angiostatin protein significantly suppresses the growth of a variety of tumors in mice. However, the dosages of angiostatin protein used in these animal studies seem to be too high for clinical trials. In addition, repeated injections and long-term treatment with angiostatin are required to reach its maximal antitumor effect. In this article, I will discuss several alternative approaches that may become feasible to move angiostatin therapy from animal experiments into the clinic. In particular, I will emphasize the therapeutic potentials of angiostatin gene therapy and more potent angiogenesis inhibitors that are related to angiostatin. (+info)Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. (8/210)
Gene therapy transfer of angiostatin and endostatin represents an alternative method of delivering angiogenic polypeptide inhibitors. We examined whether liposomes complexed to plasmids encoding angiostatin or endostatin inhibited angiogenesis and the growth of MDA-MB-435 tumors implanted in the mammary fat pads of nude mice. We determined that plasmids expressing angiostatin (PCI-Angio) or endostatin (PCI-Endo) effectively reduced angiogenesis using an in vivo Matrigel assay. We then investigated the efficacy of these plasmids in reducing the size of tumors implanted in the mammary fat pad of nude mice. Both PCI-Angio and PCI-Endo significantly reduced tumor size when injected intratumorally (P < 0.05). Compared to the untreated control group, the mice treated with PCI-Angio and PCI-Endo exhibited a reduction in tumor size of 36% and 49%, respectively. In addition, we found that i.v. injections of liposomes complexed to PCI-Endo reduced tumor growth in the nude mice by nearly 40% when compared to either empty vector (PCI) or untreated controls (P < 0.05). These findings provide a basis for the further development of nonviral delivery of antiangiogenic genes. (+info)Angiostatins at the US National Library of Medicine Medical Subject Headings (MeSH). ...
Moreover, NK4 is structurally similar to angiostatins, which is why it possesses anti-angiogenic activity. Neutralizing anti- ...
Examples of beta globulins include: beta-2 microglobulin plasminogen angiostatins properdin sex hormone-binding globulin ...
... angiostatins MeSH D12.776.377.715.182.624 - properdin MeSH D12.776.377.715.182.800 - sex hormone-binding globulin MeSH D12.776. ... angiostatins MeSH D12.776.467.100.450.750 - endostatins MeSH D12.776.467.100.800.200 - vascular endothelial growth factor a ...
... angiostatins MeSH D12.776.124.790.223.624 -- properdin MeSH D12.776.124.790.223.800 -- sex hormone-binding globulin MeSH ...
... angiostatins MeSH D08.811.074.124 --- deoxyribodipyrimidine photo-lyase MeSH D08.811.074.249 --- dna glycosylases MeSH D08.811. ...
... angiostatins MeSH D23.348.479.311.200.750 --- endostatins MeSH D23.348.479.311.300 --- fibroblast growth factor 1 MeSH D23.348. ...
... angiostatins MeSH D12.644.276.100.450.750 --- endostatins MeSH D12.644.276.100.800 --- vascular endothelial growth factors MeSH ...
Angiostatins, which are kringle-containing fragments of plasminogen/plasmin, are known to be powerful physiological inhibitors ... Also, role of angiostatins in the pathogenesis of typical diabetic complications, including retinopathies, nephropathies and ... Reference: Tykhomyrov A.A., Shram S.I., Grinenko T.V., Role of angiostatins in diabetic complications, Biomeditsinskaya khimiya ... In the present review, current literature data on peculiarities of production of angiostatins and their functioning at diabetes ...
angiostatins (1) * bevacizumab (1) * central serous chorioretinopathy (1) * choroidal neovascularization (1) * collagen (1) ...
01/01/2005 - "Because corneal cells generate angiostatins, use of human angiostatins may be a means of treating abnormal ... AngiostatinsIBA 05/15/2007 - "MAb3D5AB1 disrupts tube formation and decreases intracellular pH in endothelial cells exposed to ...
Angiostatins at the US National Library of Medicine Medical Subject Headings (MeSH). ...
Moreover, NK4 is structurally similar to angiostatins, which is why it possesses anti-angiogenic activity. Neutralizing anti- ...
Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity. ...
... angiostatins?), cancers that should remain untreated and monitored instead get invasive surgery (prostate cancer)... yes, ...
The molecular mechanisms governing angiostatins antiangiogenic and antitumor effects are not well understood. Here, we report ...
102000012936 Angiostatins Human genes 0 description 1 * 108020004491 Antisense DNA Proteins 0 description 1 ...
Inhibitory effect of angiostatins on activity of the plasminogen/plasminogen activator system. Biochemistry 74:1104-1113PubMed ...
Angiostatins Expression of alternatively spliced isoforms of platelet endothelial cell adhesion molecule-1 of embryonic stem ...
Yeast two-hybrid screening for angiostatin-binding proteins in a human placenta cDNA library. (A) Yeast transfected with the angiostatin-Gal4 binding domain and
102000012936 Angiostatins Human genes 0 description 1 * 108010079709 Angiostatins Proteins 0 description 1 ...
Effect of external ocular surgery and mode of post-operative care on plasminogen, plasmin, angiostatins and alpha(2)- ...
... endostatins or angiostatins), tissue irritants (e.g., a compound comprising talc), poisons (e.g., arsenic), cytotoxic agents (e ...
... angiostatins, endostatins, etc.) [2]. Angiogenesis is necessary for tumors to grow beyond a few millimeters and is triggered by ...
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V. We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
Angiostatins. Phase 1. 16. Leukotriene Antagonists. Phase 1. 17. Hormones. Phase 1. ...
... and further process the protein enzymatically to generate different forms of anti-angiogenic angiostatins. I guess ever since ...
... not only regulate the production of angiogenic factors such as IL-8 and VEGF but also that of as-yet-unidentified angiostatins ...
4, 5, 6 ). Endogenous antiangiogenic factors such as angiostatins are overwhelmed by proangiogenic secretions such as VEGF, ...
Angiostatins; EC 1.13.12.- / Luciferases; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; EC 2.7.7.- / ...
TY - JOUR. T1 - Macrophage elastase suppresses white adipose tissue expansion with cigarette smoking. AU - Tsuji, Takao. AU - Kelly, Neil J.. AU - Takahashi, Saeko. AU - Leme, Adriana S.. AU - Houghton, A. Mc Garry. AU - Shapiro, Steven D.. PY - 2014/12/1. Y1 - 2014/12/1. N2 - Macrophage elastase (MMP12) is a key mediator of cigarette smoke (CS)-induced emphysema, yet its role in other smoking related pathologies remains unclear. The weight suppressing effects of smoking are a major hindrance to cessation efforts, and MMP12 is known to suppress the vascularization on which adipose tissue growth depends by catalyzing the formation of antiangiogenic peptides endostatin and angiostatin. The goal of this study was to determine the role of MMP12 in adipose tissue growth and smoking-related suppression of weight gain. Whole body weights and white adipose depots from wild-type and Mmp12-deficient mice were collected during early postnatal development and after chronic CS exposure. Adipose tissue ...
Aleman, T. S., Sandhu, H. S., Serrano, L. W., Traband, A., Lau, M. K., Adamus, G. & Avery, R. A., May 1 2017, In : JAMA Ophthalmology. 135, 5, p. 487-490 4 p.. Research output: Contribution to journal › Article ...
Iles, M. M., Law, M. H., Stacey, S. N., Han, J., Fang, S., Pfeiffer, R., Harland, M., MacGregor, S., Taylor, J. C., Aben, K. K., Akslen, L. A., Avril, M. F., Azizi, E., Bakker, B., Benediktsdottir, K. R., Bergman, W., Scarrà, G. B., Brown, K. M., Calista, D., Chaudru, V. & 70 others, Fargnoli, M. C., Cust, A. E., Demenais, F., De Waal, A. C., Dȩbniak, T., Elder, D. E., Friedman, E., Galan, P., Ghiorzo, P., Gillanders, E. M., Goldstein, A. M., Gruis, N. A., Hansson, J., Helsing, P., Hočevar, M., Höiom, V., Hopper, J. L., Ingvar, C., Janssen, M., Jenkins, M. A., Kanetsky, P. A., Kiemeney, L. A., Lang, J., Lathrop, G. M., Leachman, S., Lee, J. E., Lubiński, J., MacKie, R. M., Mann, G. J., Martin, N. G., Mayordomo, J. I., Molven, A., Mulder, S., Nagore, E., Novaković, S., Okamoto, I., Olafsson, J. H., Olsson, H., Pehamberger, H., Peris, K., Grasa, M. P., Planelles, D., Puig, S., Puig-Butille, J. A., Randerson-Moor, J., Requena, C., Rivoltini, L., Rodolfo, M., Santinami, M., Sigurgeirsson, B., ...
- Angiostatins, which are kringle-containing fragments of plasminogen/plasmin, are known to be powerful physiological inhibitors of neovascularization. (msk.ru)
- Aisina RB, Mukhametova LI, Gulin DA, Levashov MY, Prisyazhnaya NV, Gershkovich KB, Varfolomeyev SD (2009) Inhibitory effect of angiostatins on activity of the plasminogen/plasminogen activator system. (springer.com)
- Afternoon sessions will consist of hands-on laboratory exercises and demonstrations covering basic quantitative molecular biology protocols and tools, e.g QRTPCR quantitation of p21/p53 expression in fibroblast cultures after UV exposure, tissue culture systems (including growth factor dependent and 3D systems) and surrogate in vivo tumor model systems, e.g. perturbations of chick growth and angiogenesis by angiostatins/VEGF. (uci.edu)