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These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.Diagnostic Techniques and Procedures: Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.Electrophoresis, Cellulose Acetate: Electrophoresis in which cellulose acetate is the diffusion medium.Paraproteins: Abnormal immunoglobulins synthesized by atypical cells of the MONONUCLEAR PHAGOCYTE SYSTEM. Paraproteins containing only light chains lead to Bence Jones paraproteinemia, while the presence of only atypical heavy chains leads to heavy chain disease. Most of the paraproteins show themselves as an M-component (monoclonal gammopathy) in electrophoresis. Diclonal and polyclonal paraproteins are much less frequently encountered.Angiostatins: Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Intercellular Signaling Peptides and Proteins: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Figural Aftereffect: A perceptual phenomenon used by Gestalt psychologists to demonstrate that events in one part of the perceptual field may affect perception in another part.Diffusion Chambers, Culture: Devices used in a technique by which cells or tissues are grown in vitro or, by implantation, in vivo within chambers permeable to diffusion of solutes across the chamber walls. The chambers are used for studies of drug effects, osmotic responses, cytogenic and immunologic phenomena, metabolism, etc., and include tissue cages.Chemotaxis: The movement of cells or organisms toward or away from a substance in response to its concentration gradient.Afterimage: Continuation of visual impression after cessation of stimuli causing the original image.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Vascular Patency: The degree to which BLOOD VESSELS are not blocked or obstructed.Lung Diseases, Obstructive: Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Forced Expiratory Volume: Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Spirometry: Measurement of volume of air inhaled or exhaled by the lung.Urogenital Neoplasms: Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.Access to Information: Individual's rights to obtain and use information collected or generated by others.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Angiogenesis Inhibitors: Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Phonetics: The science or study of speech sounds and their production, transmission, and reception, and their analysis, classification, and transcription. (Random House Unabridged Dictionary, 2d ed)DictionaryDictionaries, PharmaceuticLanguage: A verbal or nonverbal means of communicating ideas or feelings.Dictionaries, DentalSpeech: Communication through a system of conventional vocal symbols.

Angiostatin binds ATP synthase on the surface of human endothelial cells. (1/210)

Angiostatin, a proteolytic fragment of plasminogen, is a potent antagonist of angiogenesis and an inhibitor of endothelial cell migration and proliferation. To determine whether the mechanism by which angiostatin inhibits endothelial cell migration and/or proliferation involves binding to cell surface plasminogen receptors, we isolated the binding proteins for plasminogen and angiostatin from human umbilical vein endothelial cells. Binding studies demonstrated that plasminogen and angiostatin bound in a concentration-dependent, saturable manner. Plasminogen binding was unaffected by a 100-fold molar excess of angiostatin, indicating the presence of a distinct angiostatin binding site. This finding was confirmed by ligand blot analysis of isolated human umbilical vein endothelial cell plasma membrane fractions, which demonstrated that plasminogen bound to a 44-kDa protein, whereas angiostatin bound to a 55-kDa species. Amino-terminal sequencing coupled with peptide mass fingerprinting and immunologic analyses identified the plasminogen binding protein as annexin II and the angiostatin binding protein as the alpha/beta-subunits of ATP synthase. The presence of this protein on the cell surface was confirmed by flow cytometry and immunofluorescence analysis. Angiostatin also bound to the recombinant alpha-subunit of human ATP synthase, and this binding was not inhibited by a 2,500-fold molar excess of plasminogen. Angiostatin's antiproliferative effect on endothelial cells was inhibited by as much as 90% in the presence of anti-alpha-subunit ATP synthase antibody. Binding of angiostatin to the alpha/beta-subunits of ATP synthase on the cell surface may mediate its antiangiogenic effects and the down-regulation of endothelial cell proliferation and migration.  (+info)

Angiostatin formation involves disulfide bond reduction and proteolysis in kringle 5 of plasmin. (2/210)

Plasmin is processed in the conditioned medium of HT1080 fibrosarcoma cells producing fragments with the domain structures of the angiogenesis inhibitor, angiostatin, and microplasmin. Angiostatin consists of kringle domains 1-4 and part of kringle 5, while microplasmin consists of the remainder of kringle 5 and the serine proteinase domain. Our findings indicate that formation of angiostatin/microplasmin involves reduction of plasmin by a plasmin reductase followed by proteolysis of the reduced enzyme. We present evidence that the Cys461-Cys540 and Cys511-Cys535 disulfide bonds in kringle 5 of plasmin were reduced by plasmin reductase. Plasmin reductase activity was secreted by HT1080 and Chinese hamster ovary cells and the human mammary carcinoma cell lines MCF-7, MDA231, and BT20 but not by the monocyte/macrophage cell line THP-1. Neither primary foreskin fibroblasts, blood monocyte/macrophages, nor macrovascular or microvascular endothelial cells secreted detectable plasmin reductase. In contrast, cultured bovine and rat vascular smooth muscle cells secreted small but reproducible levels of plasmin reductase. Reduction of the kringle 5 disulfide bonds triggered cleavage at either Arg529-Lys530 or two other positions C-terminal of Cys461 in kringle 5 by a serine proteinase. Plasmin autoproteolysis could account for the cleavage, although another proteinase was mostly responsible in HT1080 conditioned medium. Three serine proteinases with apparent Mr of 70, 50, and 39 were purified from HT1080 conditioned medium, one or more of which could contribute to proteolysis of reduced plasmin.  (+info)

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. (3/210)

Solid tumors depend on angiogenesis for their growth. In a transgenic mouse model of pancreatic islet cell carcinogenesis (RIP1-Tag2), an angiogenic switch occurs in premalignant lesions, and angiogenesis persists during progression to expansive solid tumors and invasive carcinomas. RIP1-Tag2 mice were treated so as to compare the effects of four angiogenesis inhibitors at three distinct stages of disease progression. AGM-1470, angiostatin, BB-94, and endostatin each produced distinct efficacy profiles in trials aimed at preventing the angiogenic switch in premalignant lesions, intervening in the rapid expansion of small tumors, or inducing the regression of large end-stage cancers. Thus, anti-angiogenic drugs may prove most efficacious when they are targeted to specific stages of cancer.  (+info)

Systemic gene delivery expands the repertoire of effective antiangiogenic agents. (4/210)

Cationic liposome-DNA complex (CLDC)-based intravenous gene delivery targets gene expression to vascular endothelial cells, macrophages and tumor cells. We used systemic gene delivery to identify anti-angiogenic gene products effective against metastatic spread in tumor-bearing mice. Specifically, CLDC-based intravenous delivery of the p53 and GM-CSF genes were each as effective as the potent antiangiogenic gene, angiostatin, in reducing both tumor metastasis and tumor angiogenesis. Combined delivery of these genes did not increase anti-tumor activity, further suggesting that each gene appeared to produce its antimetastatic activity through a common antiangiogenic pathway. CLDC-based intravenous delivery of the human wild type p53 gene transfected up to 80% of tumor cells metastatic to lung. Furthermore, it specifically induced the expression of the potent antiangiogenic gene, thrombospondin-1, indicating that p53 gene delivery in vivo may inhibit angiogenesis by inducing endogenous thrombospondin-1 expression. CLDC-based delivery also identified a novel anti-tumor activity for the metastasis suppressor gene CC3. Thus, CLDC-based intravenous gene delivery can produce systemic antiangiogenic gene therapy using a variety of different genes and may be used to assess potential synergy of combined anti-tumor gene delivery and to identify novel activities for existing anti-tumor genes.  (+info)

Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation. (5/210)

Angiostatin, a kringle-containing fragment of plasminogen, is a potent inhibitor of angiogenesis. The mechanism(s) responsible for the anti-angiogenic properties of angiostatin are unknown. We now report that human angiostatin blocks plasmin(ogen)-enhanced in vitro invasion of tissue plasminogen activator (t-PA)-producing endothelial and melanoma cells. Kinetic analyses demonstrated that angiostatin functions as a non-competitive inhibitor of extracellular-matrix (ECM)-enhanced, t-PA-catalysed plasminogen activation, with a Ki of 0.9+/-0.03 microM. This mechanism suggests that t-PA has a binding site for the inhibitor angiostatin, as well as for its substrate plasminogen that, when occupied, prevents ternary complex formation between t-PA, plasminogen and matrix protein. Direct binding experiments confirmed that angiostatin bound to t-PA with an apparent Kd [Kd(app)] of 6.7+/-0.7 nM, but did not bind with high affinity to ECM proteins. Together, these data suggest that angiostatin in the cellular micro-environment can inhibit matrix-enhanced plasminogen activation, resulting in reduced invasive activity, and suggest a biochemical mechanism whereby angiostatin-mediated regulation of plasmin formation could influence cellular migration and invasion.  (+info)

Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. (6/210)

Proteolytic enzymes are involved in generation of a number of endogenous angiogenesis inhibitors. Previously, we reported that angiostatin, a potent angiogenesis inhibitor, is a proteolytic fragment containing the first four kringle modules of plasminogen. In this report, we demonstrate that urokinase-activated plasmin can process plasminogen to release an angiogenesis inhibitor, K1-5 (protease-activated kringles 1-5). K1-5 inhibits endothelial-cell proliferation with a half-maximal concentration of approximately 50 pM. This inhibitory effect is endothelial-cell-specific and appears to be at least approximately 50-fold greater than that of angiostatin. A synergistic efficacy of endothelial inhibition was observed when angiostatin and kringle 5 (K5) were coincubated with capillary endothelial cells. The synergistic effect is comparable to that produced by K1-5 alone. Systemic treatment of mice with K1-5 at a low dose significantly blocked the fibroblast growth factor-induced corneal neovascularization, whereas angiostatin had no effect at the same dose. K1-5 also suppressed angiogenesis in chicken embryos. Systemic administration of K1-5 at a low dose at which angiostatin was ineffective significantly suppressed the growth of a murine T241 fibrosarcoma in mice. The antitumor effect correlates with the reduced neovascularization. These findings suggest that the plasmin-mediated proteolysis may be involved in the negative switch of angiogenesis.  (+info)

Therapeutic potentials of angiostatin in the treatment of cancer. (7/210)

The discovery of specific endothelial inhibitors such as angiostatin and endostatin not only increases our understanding of the functions of these molecules in the regulation of physiological and pathological angiogenesis, but also provides an important therapeutic strategy for cancer treatment. Recent studies have demonstrated that the angiostatin protein significantly suppresses the growth of a variety of tumors in mice. However, the dosages of angiostatin protein used in these animal studies seem to be too high for clinical trials. In addition, repeated injections and long-term treatment with angiostatin are required to reach its maximal antitumor effect. In this article, I will discuss several alternative approaches that may become feasible to move angiostatin therapy from animal experiments into the clinic. In particular, I will emphasize the therapeutic potentials of angiostatin gene therapy and more potent angiogenesis inhibitors that are related to angiostatin.  (+info)

Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. (8/210)

Gene therapy transfer of angiostatin and endostatin represents an alternative method of delivering angiogenic polypeptide inhibitors. We examined whether liposomes complexed to plasmids encoding angiostatin or endostatin inhibited angiogenesis and the growth of MDA-MB-435 tumors implanted in the mammary fat pads of nude mice. We determined that plasmids expressing angiostatin (PCI-Angio) or endostatin (PCI-Endo) effectively reduced angiogenesis using an in vivo Matrigel assay. We then investigated the efficacy of these plasmids in reducing the size of tumors implanted in the mammary fat pad of nude mice. Both PCI-Angio and PCI-Endo significantly reduced tumor size when injected intratumorally (P < 0.05). Compared to the untreated control group, the mice treated with PCI-Angio and PCI-Endo exhibited a reduction in tumor size of 36% and 49%, respectively. In addition, we found that i.v. injections of liposomes complexed to PCI-Endo reduced tumor growth in the nude mice by nearly 40% when compared to either empty vector (PCI) or untreated controls (P < 0.05). These findings provide a basis for the further development of nonviral delivery of antiangiogenic genes.  (+info)

*Angiostatin

Angiostatins at the US National Library of Medicine Medical Subject Headings (MeSH). ...

*C-Met

Moreover, NK4 is structurally similar to angiostatins, which is why it possesses anti-angiogenic activity. Neutralizing anti- ...

*Beta globulins

Examples of beta globulins include: beta-2 microglobulin plasminogen angiostatins properdin sex hormone-binding globulin ...

*List of MeSH codes (D12.776)

... angiostatins MeSH D12.776.377.715.182.624 - properdin MeSH D12.776.377.715.182.800 - sex hormone-binding globulin MeSH D12.776. ... angiostatins MeSH D12.776.467.100.450.750 - endostatins MeSH D12.776.467.100.800.200 - vascular endothelial growth factor a ...

*List of MeSH codes (D12.776.124)

... angiostatins MeSH D12.776.124.790.223.624 -- properdin MeSH D12.776.124.790.223.800 -- sex hormone-binding globulin MeSH ...

*List of MeSH codes (D08)

... angiostatins MeSH D08.811.074.124 --- deoxyribodipyrimidine photo-lyase MeSH D08.811.074.249 --- dna glycosylases MeSH D08.811. ...

*List of MeSH codes (D23)

... angiostatins MeSH D23.348.479.311.200.750 --- endostatins MeSH D23.348.479.311.300 --- fibroblast growth factor 1 MeSH D23.348. ...

*List of MeSH codes (D12.644)

... angiostatins MeSH D12.644.276.100.450.750 --- endostatins MeSH D12.644.276.100.800 --- vascular endothelial growth factors MeSH ...
Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity ...
The discovery of specific endothelial inhibitors such as angiostatin and endostatin not only increases our understanding of the functions of these molecules in the regulation of physiological and pathological angiogenesis, but also provides an important therapeutic strategy for cancer treatment. Recent studies have demonstrated that the angiostatin protein significantly suppresses the growth of a variety of tumors in mice. However, the dosages of angiostatin protein used in these animal studies seem to be too high for clinical trials. In addition, repeated injections and long-term treatment with angiostatin are required to reach its maximal antitumor effect. In this article, I will discuss several alternative approaches that may become feasible to move angiostatin therapy from animal experiments into the clinic. In particular, I will emphasize the therapeutic potentials of angiostatin gene therapy and more potent angiogenesis inhibitors that are related to angiostatin.. ...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
|p|Angiostatin is proteolytically processed from plasminogen, a secreted blood zymogen. Angiostatin reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.|/p| |p|Recombinant Human Angiostatin, Kringle doma
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.; Includes bibliographical references (leaves 44-46 ...
Principal Investigator:OKADA Yasuo, Project Period (FY):1998 - 2000, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Surgical dentistry
Migration of MAE cells transfected with angiomotin or with the vector alone was studied in the modified Boyden chamber assay. (A) Analysis of spontaneous migrat
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In this study, we demonstrated that both the angiogenic factor VEGF and antiangiogenic factors endostatin and angiostatin were significantly increased in the rat colon with experimental UC. The increased levels of endostatin and angiostatin were reversed significantly (75-95%) by 5-ASA treatment, whereas 5-ASA treatment did not change VEGF expression. Because 5-ASA could inhibit angiogenesis through up-regulating expression of PPAR-γ, which is a downstream inhibitor of VEGF-induced angiogenesis (Murata et al., 2000), it was not surprising that the levels of VEGF did not change. It is possible that increased VEGF and simultaneously up-regulated endostatin and angiostatin contribute to pathologic angiogenesis. This study indicates that the effectiveness of 5-ASA on UC healing may be directly related to down-regulation of the antiangiogenic factors endostatin and angiostatin in UC.. Because angiostatin and endostatin could be generated by MMP2 and MMP9 through cleavage of collagen XVIII and ...
The Human Angiostatin ELISA research-use-only kit is an enzyme-linked immunosorbent assay designed for the quantitation and detection of Angiostatin in samples (see sample types indicated) using a microplate reader. The assay will recognize both natural and recombinant forms of this target.This comp
Nucleic acid sequences encoding kringle region fragments of plasminogen. Ribonucleic and deoxyribonucleic acid sequences that encode for kringle region fragments are useful for gene therapy or recombinant expression for the treatment of angiogenesis-related diseases, specifically angiogenesis-dependent cancer.
Approach and Results-Rats underwent transient, repetitive left anterior descending occlusion (resultant myocardial ischemia [RI]) for 0 to 10 days. CCG was measured in the collateral-dependent and normal zones using microspheres, MMP activation by Western blot, and endostatin and angiostatin by ELISA on days 0, 3, 6, 9, or 10 of RI. Endostatin and angiostatin were increased in JCR but not in Sprague Dawley rats on days 6 and 9 of RI. Increased endostatin and angiostatin correlated with increased MMP12 (≈4-fold) activation in JCR but not in Sprague Dawley rats on days 6 and 9 of RI. Inhibition of MMP12 in JCR rats nearly completely blocked endostatin (≈85%) and angiostatin (≈90%) generation and significantly improved CCG (collateral-dependent zone flow was ≈66% of normal zone flow versus ≈12% for JCR RI).. ...
TY - JOUR. T1 - Increased angiostatin levels in bronchoalveolar lavage fluids from ARDS patients and from human volunteers after lung instillation of endotoxin. AU - Lucas, Rudolf. AU - Lijnen, H. Roger. AU - Suffredini, Anthony F.. AU - Pepper, Michael S.. AU - Steinberg, Kenneth P.. AU - Martin, Thomas R.. AU - Pugin, Jérôme. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Acute respiratory distress syndrome (ARDS) is characterized by a disruption of the alveolar-capillary barrier, due to both an epithelial and an endothelial dysfunction. Whereas epithelial apoptosis seems to be mainly mediated by Fas ligand, the mediators of endothelial damage remain to be identified. Angiostatin, a powerful inhibitor of angiogenesis in vivo, also specifically induces apoptosis in endothelial cells. The concentration of various enzymes that cleave angiostatin from plasminogen was reported to be significantly increased in bronchalveolar lavage (BAL) fluids from patients with ARDS. Therefore, in this study, we ...
Looking for online definition of angiomotin p130 isoform in the Medical Dictionary? angiomotin p130 isoform explanation free. What is angiomotin p130 isoform? Meaning of angiomotin p130 isoform medical term. What does angiomotin p130 isoform mean?
Calories in Shop N Save Milk Skim (Fat Free Skim Milk. Find nutrition facts for Shop N Save Milk Skim (Fat Free Skim Milk and over 2,000,000 other foods in MyFitnessPal.coms food database.
Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions than gamma globulins, but less mobile than alpha globulins. Examples of beta globulins include: beta-2 microglobulin plasminogen angiostatins properdin sex hormone-binding globulin transferrin Ren Zhang; Yan Lin & Chun-Ting Zhang (2008). "Greglist: a database listing potential G-quadruplex regulated genes". Nucleic Acids Res. 36 (suppl 1): D372-D376. doi:10.1093/nar/gkm787. Phillip A. Rachwal; I. Stuart Findlow; Joern M. Werner; Tom Brown & Keith R. Fox (2007). "Intramolecular DNA quadruplexes with different arrangements of short and long loops". Nucleic Acids Res. 35 (12): 4214-4222. doi:10.1093/nar/gkm316. Antonio Randazzo; Veronica Esposito; Oliver Ohlenschläger; Ramadurai Ramachandran; Antonella Virgilio & Luciano Mayol (2005). "Structural studies on LNA quadruplexes". Nucleosides, Nucleotides and Nucleic Acids. 24 (5-7): 795-800. doi:10.1081/NCN-200060279. "Examples ...
The angiogenic switch, a rate-limiting step in tumor progression, has already occurred by the time most human tumors are detectable. The angiogenic switch is not limited at earliest stages, but occurs also at different stages of tumor progression (2). Antiangiogenic therapy is a promising alternative for treatment of cancer, and may also be used as a maintenance therapy to prevent the metastasis or recurrence (4). Therapy with endogenous angiogenic inhibitors such as endostatin and angiostatin may reverse the angiogenic switch by preventing growth of tumor vasculature. Angiostatin can maintain metastases in a dormant state in laboratory animals when administered exogenously (34). In transgenic mice overexpressing endostatin, a small increase of circulating endostatin (approximately 1.6-fold) is sufficient to confer dramatic protection against tumor growth (11). In individuals with Down syndrome, a similar small increase of circulating endostatin is associated with a remarkably low incidence of ...
Health, ...The beneficial effects of anti-angiogenesis drugs in the treatment of ... Our findings suggest that antiangiogenesis therapy can increase patie...Cediranib inhibits the potent angiogenesis factor VEGF which is known... We frequently see beneficial effects from drugs in patients without f...,Angiogenesis,inhibitor,improves,brain,tumor,survival,by,reducing,edema,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
The present study demonstrated the validity and superiority of CD105 as a marker of angiogenesis in NSCLC; the CD105-IMVD was more closely correlated with the expression of VEGF than the CD34-IMVD. Kumar et al. (11 , 13 , 15, 16, 17, 18) and others have demonstrated that anti-CD105 antibodies preferentially react with activated ECs in tissues participating in angiogenesis, such as tumor tissues, and that antibodies against pan-ECs, such as anti-CD34 antibodies, react with normal vessels, as well as activated vessels. According to the hypothesis, we tried to define the CD34-IMVD-CD105-IMVD as the baseline IMVD. As a result, the baseline IMVD proved not at all to be correlated with VEGF expression, suggesting the baseline IMVD was not a measurement of angiogenesis but a measurement of vessels just trapped within tumor tissues. Of course, it should be noted that angiogenesis is not influenced only by VEGF but also other angiogenic factors and antiangiogenic factors, such as angiostatin. Comparative ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
0053] Numerous anti-angiogenesis factors are well known and thoroughly documented in the art (see, for example, PCT/US99/08335). Examples of anti-angiogenesis factors useful in the practice of the invention, include, for example, protein/peptide inhibitors of angiogenesis such as: angiostatin, a proteolytic fragment of plasminogen (OReilly et al. (1994) CELL 79: 315-328, and U.S. Pat. Nos. 5,733,876; 5,837,682; and 5,885,795) including full length amino acid sequences of angiostatin, bioactive fragments thereof, and analogs thereof; endostatin, a proteolytic fragment of collagen XVIII (OReilly et al. (1997) CELL 88: 277-285, Cirri et al. (1999) INT. BIOL. MARKER 14: 263-267, and U.S. Pat. No. 5,854,205) including full length amino acid sequences of endostatin, bioactive fragments thereof, and analogs thereof; peptides containing the RGD tripeptide sequence and capable of binding the αvβ3 integrin (Brooks et al. (1994) CELL 79: 1157-1164, Brooks et al. (1994) SCIENCE 264: 569-571); certain ...
Gentaur molecular products has all kinds of products like :search , Reliatech \ Anti_Mouse, mab Endostatin Source Rat \ 103-M200 for more molecular products just contact us
talk about being a jerk. with that comment you seem to fit the description pretty well. and besides being a jerk people who list things off come across as really bossy and annoying. i dont know what planet your from but here on earth if you are kissing, sucking, and fucking men and you are a man yourself i think being labeled as straight is a bit of a stretch. dont believe me, ask any real straight guy. if anything maybe hes bi. and how the hell would you know that this is "literally" his first male fuck? i mean who really knows what he does in private. i used to think he was hot when he just did xtube videos with his sunglasses on but now he has turned into just another dime a dozen boring gay for payer. by the way, do work for cockyboys or are you his manager? maybe his "girlfriend?" because you seem to consider yourself an expert when it comes to all things bravo delta.. ...
Castration experiments in rodents show that the stromal vasculature is critical to the androgen-mediated prostate growth regulation. However, the role of angiogenesis inhibitors, such as thrombospondin-1 (TSP-1), in this process is unclear. TSP-1 is a multifunctional glycoprotein that can function as a potent angiogenesis inhibitor and an in vivo activator of latent transforming growth factor-beta (TGF-beta) in some tissues. On the basis of these observations, we hypothesized that TSP-1 regulated androgen withdrawal-induced prostate regression and that this process was mediated not only through antiangiogenic activity but also through TGF-beta activation. To test this, we evaluated angiogenic activity in human prostate epithelial and stromal cells treated with androgens and hypoxia in vitro. TSP-1 knockout mice were characterized to investigate the in vivo functions of TSP-1. In vitro, we found that androgens and hypoxia differentially regulated TSP-1 and angiogenic activity. Androgens ...
These studies demonstrate for the first time that MMPs cleave PRL to generate antiangiogenic 16K-PRL. 16K-PRL blocks a variety of endothelial cell functions (Corbacho et al., 2002; Gonzalez et al., 2004; Lee et al., 2005) and inhibits angiogenesis in ocular tissues (Dueñas et al., 1999; Pan et al., 2004; Aranda et al., 2005) and in tumors (Bentzien et al., 2001; Kim et al., 2003). The specific enzymes responsible for generating 16K-PRL are largely unknown. MMPs cleave various proteins to release their bioactive forms, including the antiangiogenic fragments angiostatin (Patterson and Sang, 1997; Lijnen et al., 1998; OReilly et al., 1999) and endostatin (Lin et al., 2001). Considering that the release of antiangiogenic fragments occurs in avascular tissues such as cartilage (Pufe et al., 2004), we focused on whether chondrocyte MMPs could process PRL to 16K-PRL.. We demonstrate that MMPs produced and secreted by chondrocytes cleave PRL to generate biologically active 16K-PRL. Cleavage occurs at ...
This KSA Kringles burgundy and brown Santa with list from Kurt Adler is a fun and festive addition to any holiday décor. Part of the KSA Kringles collection, this Santa Claus is wearing a deep burgundy robe and hat, both trimmed in faux brown fur. He is holding a list of names trimmed in gold, a feather quill, and is wearing a pocket watch ...
Racine Danish Kringles is a hand-crafted pastry and makes an ideal gift for todays gourmet shopper. Enjoy a cup of gourmet coffee with your delicious Kringle.
Ive made gingerbread for the past 10 years, every single Christmas. Its delicious, but definitely a lot of work. This year I decided to branch out a little bit and instead of doing the "roll and decorate" gingerbread, I wanted to try a chewy molasses cookie. After searching foodgawker for what seemed like hours, I decided to go with a recipe from What Megans Making for molasses kringles. They certainly did not disappoint. They are soft, chewy, spicy and just a bit sweet. I when I make them again Ill ditch the glaze though. I think it made them just a bit too sweet. If you want the recipe for the glaze, check out Megans original recipe ...
In left ventricular (LV) pressure-overload hypertrophy, lack of adaptive capillary growth contributes to progression to failure. Remodeling of the hypertrophied myocardium requires proteolysis of the extracellular matrix (ECM) carried out by matrix m
Until now, in trials it is common to stop therapy when progressive disease occurs; RECIST criteria are used, in which progressive disease is defined as ,20% increase of the sum of the longest diameter of the lesions, or occurence of new lesions. However, angiogenesis inhibitors have a rather cytostatic than cytotoxic effect compared to chemotherapeutics, as a result of which less frequently reduction of tumor volume is being seen.. Often in the centre of the lesion necrosis is shown. Sometimes accompanied with edema; so even tumor volume increase can be the result without real progression being the case. Recently, in our clinic, we found a number of patients, treated with oral angiogenesis inhibitors, a remarkable quickening of progressive disease and complaints after stopping this treatment. Reintroduction of the same or another type of angiogenesis inhibitor subsequently lead to a new stabilization. The causality of this phenomenon is unknown. Perhaps that the inhibitory effect of the ...
Although siDrp1 cells that entered mitosis were able to sustain the mitotic arrest longer than siLuc cells, we noticed that many siDrp1 cells failed to enter mitosis and appeared unhealthy. Indeed, Drp1 depletion has been reported to cause cell cycle defects and a G2 delay (Qian et al, 2012; Westrate et al, 2014). To avoid complications from these interphase phenotypes caused by siDrp1, we inhibited Drp1 in U2OS cells at the time of mitotic entry with the chemical inhibitor of Drp1 Mdivi‐1 (Cassidy‐Stone et al, 2008) and analyzed the kinetics of mitotic adaptation with FACS. An increasing percentage of cells underwent mitotic adaptation with increasing time in taxol, as evidenced by the appearance of MPM2‐negative population (Fig 7C; indicated by red arrows). Chemical inhibition of Drp1 with Mdivi‐1 largely blocked mitotic adaptation in these cells (Fig 7C and D). Addition of cycloheximide to mitotic cells treated with Mdivi‐1 accelerated mitotic adaptation (Fig 7C and D). The fact ...
Christmas Day I went on Saltwaterfish.com and they had an octopus available. He is in transit. Im keeping my fingers crossed. I have no idea what kind...
The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance - many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. This volume brings together 5 reviews on these topics: ...
New research indicates that a new way of analyzing data acquired in MR imaging appears to be able to identify whether or not tumors are responding to anti-angiogenesis therapy.
Sometimes called antiangiogenic therapy, this treatment may prevent the growth of cancer by blocking the formation of new blood vessels.
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
T103N: alteplase variant; contains additional glycosylation site in the first kringle domain; causes substantial reduction in clearance rate
Browse Chile, Mining, Seawater, Reverse Osmosis, Water Quality, Malta items by tag, keyword or phrase on Water. desalination + reuse. Click on a keyword to refine the search further

Role of angiostatins in diabetic complicationsRole of angiostatins in diabetic complications

Angiostatins, which are kringle-containing fragments of plasminogen/plasmin, are known to be powerful physiological inhibitors ... Also, role of angiostatins in the pathogenesis of typical diabetic complications, including retinopathies, nephropathies and ... Reference: Tykhomyrov A.A., Shram S.I., Grinenko T.V., Role of angiostatins in diabetic complications, Biomeditsinskaya khimiya ... In the present review, current literature data on peculiarities of production of angiostatins and their functioning at diabetes ...
more infohttp://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-2015-61-1-41-en

Corneal Neovascularization
     Summary Report | CureHunterCorneal Neovascularization Summary Report | CureHunter

01/01/2005 - "Because corneal cells generate angiostatins, use of human angiostatins may be a means of treating abnormal ... AngiostatinsIBA 05/15/2007 - "MAb3D5AB1 disrupts tube formation and decreases intracellular pH in endothelial cells exposed to ...
more infohttp://www.curehunter.com/public/keywordSummaryD016510-Corneal-Neovascularization.do

Yeast two-hybrid screening for angiostatin-binding prot | Open-iYeast two-hybrid screening for angiostatin-binding prot | Open-i

Yeast two-hybrid screening for angiostatin-binding proteins in a human placenta cDNA library. (A) Yeast transfected with the angiostatin-Gal4 binding domain and
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2199208_JCB0010121.f1&req=4

US20050149161A1 - Edge protection and bifurcated stent delivery system 
        - Google PatentsUS20050149161A1 - Edge protection and bifurcated stent delivery system - Google Patents

102000012936 Angiostatins Human genes 0 description 1 * 108020004491 Antisense DNA Proteins 0 description 1 ...
more infohttps://patents.google.com/patent/US20050149161A1/en

Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug InformationDrug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information

Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity. ...
more infohttps://druginfo.nlm.nih.gov/drugportal/rn/86090-08-6

US10285831B2 - Endovascular implant 
        - Google PatentsUS10285831B2 - Endovascular implant - Google Patents

102000012936 Angiostatins Human genes 0 description 1 * 108010079709 Angiostatins Proteins 0 description 1 ...
more infohttps://patents.google.com/patent/US10285831B2/en

JoVE | Peer Reviewed Scientific Video Journal - Methods and ProtocolsJoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

The molecular mechanisms governing angiostatins antiangiogenic and antitumor effects are not well understood. Here, we report ...
more infohttps://www.jove.com/visualize?author=Amir%20Abdollahi%20

Why a Cure For Cancer Is So Elusive - SlashdotWhy a Cure For Cancer Is So Elusive - Slashdot

... angiostatins?), cancers that should remain untreated and monitored instead get invasive surgery (prostate cancer)... yes, ...
more infohttps://science.slashdot.org/story/14/01/05/1910236/why-a-cure-for-cancer-is-so-elusive

Angiostatin - WikipediaAngiostatin - Wikipedia

Angiostatins at the US National Library of Medicine Medical Subject Headings (MeSH). ...
more infohttps://en.wikipedia.org/wiki/Angiostatin

Adamus, G.<...Adamus, G.<...

Aleman, T. S., Sandhu, H. S., Serrano, L. W., Traband, A., Lau, M. K., Adamus, G. & Avery, R. A., May 1 2017, In : JAMA Ophthalmology. 135, 5, p. 487-490 4 p.. Research output: Contribution to journal › Article ...
more infohttps://ohsu.pure.elsevier.com/en/persons/grazyna-adamus

C-Met - WikipediaC-Met - Wikipedia

Moreover, NK4 is structurally similar to angiostatins, which is why it possesses anti-angiogenic activity. Neutralizing anti- ...
more infohttps://en.wikipedia.org/wiki/C-Met

Beta-globulin test serum proteins electrophoresis alpha1 alpha2-globulins serum Amino acids enzymes hormones osmotic pressure...Beta-globulin test serum proteins electrophoresis alpha1 alpha2-globulins serum Amino acids enzymes hormones osmotic pressure...

angiostatins ·. properdin ·. sex hormone binding globulin ·. transferrin Proteins are the most abundant compounds in your serum ...
more infohttp://smrtx.com/1_3_51_5_beta_globulin.htm

Migration of MAE cells transfected with angiomotin or w | Open-iMigration of MAE cells transfected with angiomotin or w | Open-i

Migration of MAE cells transfected with angiomotin or with the vector alone was studied in the modified Boyden chamber assay. (A) Analysis of spontaneous migrat
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2199208_JCB0010121.f7&req=4

Increased angiostatin levels in bronchoalveolar lavage fluids from ARDS patients and from human volunteers after lung...Increased angiostatin levels in bronchoalveolar lavage fluids from ARDS patients and from human volunteers after lung...

TY - JOUR. T1 - Increased angiostatin levels in bronchoalveolar lavage fluids from ARDS patients and from human volunteers after lung instillation of endotoxin. AU - Lucas, Rudolf. AU - Lijnen, H. Roger. AU - Suffredini, Anthony F.. AU - Pepper, Michael S.. AU - Steinberg, Kenneth P.. AU - Martin, Thomas R.. AU - Pugin, Jérôme. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Acute respiratory distress syndrome (ARDS) is characterized by a disruption of the alveolar-capillary barrier, due to both an epithelial and an endothelial dysfunction. Whereas epithelial apoptosis seems to be mainly mediated by Fas ligand, the mediators of endothelial damage remain to be identified. Angiostatin, a powerful inhibitor of angiogenesis in vivo, also specifically induces apoptosis in endothelial cells. The concentration of various enzymes that cleave angiostatin from plasminogen was reported to be significantly increased in bronchalveolar lavage (BAL) fluids from patients with ARDS. Therefore, in this study, we ...
more infohttps://augusta.pure.elsevier.com/en/publications/increased-angiostatin-levels-in-bronchoalveolar-lavage-fluids-fro

DeCS Ingl s+escopoDeCS Ingl s+escopo

Angiostatins .. Angiostatin .. Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives ... Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity. .. 0.67. ... D08.622.610.500 Angiostatins .. D12 Amino Acids, Peptides, and Proteins .. D12.644 Peptides .. D12.644.276 Intercellular ... D12.644.276.100.450.500 Angiostatins .. D12.776 Proteins .. D12.776.124 Blood Proteins .. D12.776.124.790 Serum Globulins .. ...
more infohttp://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Angiosperma

Extracts from Fly Maggots and Fly Pupae as a Wound Healer | SpringerLinkExtracts from Fly Maggots and Fly Pupae as a "Wound Healer" | SpringerLink

Inhibitory effect of angiostatins on activity of the plasminogen/plasminogen activator system. Biochemistry 74:1104-1113PubMed ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-642-19382-8_14

April | 2016 | Sackler InsightApril | 2016 | Sackler Insight

... and further process the protein enzymatically to generate different forms of anti-angiogenic angiostatins. I guess ever since ...
more infohttps://sites.tufts.edu/insight/2016/04/

Patent US20050137715 - Methods and devices for maintaining patency of surgically created channels ... - Google PatentsPatent US20050137715 - Methods and devices for maintaining patency of surgically created channels ... - Google Patents

... endostatins or angiostatins), tissue irritants (e.g., a compound comprising talc), poisons (e.g., arsenic), cytotoxic agents (e ...
more infohttp://www.google.ca/patents/US20050137715

Antivascular Therapy for Epithelial Ovarian CancerAntivascular Therapy for Epithelial Ovarian Cancer

... angiostatins, endostatins, etc.) [2]. Angiogenesis is necessary for tumors to grow beyond a few millimeters and is triggered by ...
more infohttps://www.hindawi.com/journals/jo/2010/372547/

Plus itPlus it

... not only regulate the production of angiogenic factors such as IL-8 and VEGF but also that of as-yet-unidentified angiostatins ...
more infohttp://diabetes.diabetesjournals.org/content/57/8/2128

Make it Viral? - Reading WhitneyReading WhitneyMake it Viral? - Reading WhitneyReading Whitney

... or the angiostatins, which cut off the blood supply to a tumor. How could we do the same thing to bad ideas or lies that become ...
more infohttp://www.whitneyhoffman.com/2013/04/30/make-it-viral/

Plus itPlus it

4, 5, 6 ). Endogenous antiangiogenic factors such as angiostatins are overwhelmed by proangiogenic secretions such as VEGF, ...
more infohttp://cancerres.aacrjournals.org/content/63/14/3969

WikiGenes - PLG - plasminogenWikiGenes - PLG - plasminogen

We isolated a novel protease that converts plasminogen to angiostatin-like fragments (BL-angiostatins) from a culture of ...
more infohttps://www.wikigenes.org/e/gene/e/5340.html
  • Angiostatins, which are kringle-containing fragments of plasminogen/plasmin, are known to be powerful physiological inhibitors of neovascularization. (msk.ru)
  • Aisina RB, Mukhametova LI, Gulin DA, Levashov MY, Prisyazhnaya NV, Gershkovich KB, Varfolomeyev SD (2009) Inhibitory effect of angiostatins on activity of the plasminogen/plasminogen activator system. (springer.com)
  • Afternoon sessions will consist of hands-on laboratory exercises and demonstrations covering basic quantitative molecular biology protocols and tools, e.g QRTPCR quantitation of p21/p53 expression in fibroblast cultures after UV exposure, tissue culture systems (including growth factor dependent and 3D systems) and surrogate in vivo tumor model systems, e.g. perturbations of chick growth and angiogenesis by angiostatins/VEGF. (uci.edu)