Proteins that specifically inhibit the growth of new blood vessels (ANGIOGENESIS, PHYSIOLOGIC).
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A CXC chemokine that is induced by GAMMA-INTERFERON and is chemotactic for MONOCYTES and T-LYMPHOCYTES. It has specificity for the CXCR3 RECEPTOR.
Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity.
Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
CXCR receptors that are expressed on the surface of a number of cell types, including T-LYMPHOCYTES; NK CELLS; DENDRITIC CELLS; and a subset of B-LYMPHOCYTES. The receptors are activated by CHEMOKINE CXCL9; CHEMOKINE CXCL10; and CHEMOKINE CXCL11.
Doubly unsaturated pregnane derivatives with two hydroxy groups substituted anywhere on the rings or side chains.
A CXC chemokine that is induced by GAMMA-INTERFERON. It is a chemotactic factor for activated T-LYMPHOCYTES and has specificity for the CXCR3 RECEPTOR.
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.

Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. (1/25)

Platelet factor-4 (PF-4)/CXCL4 was the first chemokine described to inhibit neovascularization. Here, the product of the nonallelic variant gene of CXCL4, PF-4var1/PF-4alt, designated CXCL4L1, was isolated for the first time from thrombin-stimulated human platelets and purified to homogeneity. Although secreted CXCL4 and CXCL4L1 differ in only three amino acids, CXCL4L1 was more potent in inhibiting chemotaxis of human microvascular endothelial cells toward interleukin-8 (IL-8)/CXCL8 or basic fibroblast growth factor (bFGF). In vivo, CXCL4L1 was also more effective than CXCL4 in inhibiting bFGF-induced angiogenesis in rat corneas. Thus, activated platelets release CXCL4L1, a potent regulator of endothelial cell biology, which affects angiogenesis and vascular diseases.  (+info)

BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. (2/25)

Endorepellin, the C-terminal domain of the heparan sulfate proteoglycan perlecan, possesses angiostatic activity. The terminal laminin-like globular (LG3) domain of endorepellin appears to possess most of the biological activity on endothelial cells. LG3 protein has been detected in the urine of patients with end-stage renal disease and in the amniotic fluid of pregnant women with premature rupture of fetal membranes. These findings suggest that proteolytic processing of endorepellin and the generation of LG3 might have biological significance. In this study, we have identified specific enzymes of the bone morphogenetic protein-1 (BMP-1)/Tolloid family of metalloproteases that cleave LG3 from recombinant endorepellin at the physiologically relevant site and that cleave LG3 from endogenous perlecan in cultured mouse and human cells. The BMP-1/Tolloid family of metalloproteases is thereby implicated in the processing of a major basement membrane proteoglycan and in the liberation of an anti-angiogenic factor. Using molecular modeling, site-directed mutagenesis and angiogenic assays, we further demonstrate that LG3 activity requires specific amino acids involved in Ca(2+) coordination.  (+info)

Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. (3/25)

A group of angiogenesis inhibitors are derived from fragments of extracellular matrix or blood proteins. Endostatin, antithrombin, and anastellin are members of this group of substances. The plasma adhesion proteins fibronectin and vitronectin serve as cofactors for these three antiangiogenic proteins. Anginex is a synthetic 33-amino acid peptide that was originally modeled to reproduce the beta-sheet structure of antiangiogenic proteins. Here, we show that anginex initiates fibronectin polymerization and is inactive in mice that lack plasma fibronectin. Anginex shares these characteristics with anastellin. Fluorescein-labeled anginex and anastellin specifically localized in angiogenic vessels in vivo. This localization was dependent on plasma fibronectin and inhibited by an Arg-Gly-Asp peptide. Thus, anginex shares with several physiological angiogenesis inhibitors a dependence on plasma adhesion proteins. The role of the adhesion protein interaction apparently is to form integrin-binding complexes that deliver the antiangiogenic proteins to sites of angiogenesis. This functional convergence of several antiangiogenic factors has important implications for antiangiogenic therapies.  (+info)

Identification of CD36 molecular features required for its in vitro angiostatic activity. (4/25)

Thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, acts directly on endothelial cells (EC) via CD36 to inhibit their migration and morphogenesis induced by basic fibroblast growth factor. Here we show that CD36 triggered by TSP-1 inhibits in vitro angiogenesis stimulated by vascular endothelial growth factor-A (VEGF-A). To demonstrate that the TSP-1 inhibitory signal was mediated by CD36, we transduced CD36 in CD36-deficient endothelial cells. Both TSP-1 and the agonist anti-CD36 mAb SMO, which mimics TSP-1 activity, reduced the VEGF-A165-induced migration and sprouting of CD36-ECs. To address the mechanisms by which CD36 may exert its angiostatic function, we investigated the functional components of the C-terminal cytoplasmic tail by site-directed mutagenesis. Our results indicate that C464, R467, and K469 of CD36 are required for the inhibitory activity of TSP-1. In contrast, point mutation of C466 did not alter TSP-1 ability to inhibit EC migration and sprouting. Moreover, we show that activation of CD36 by TSP-1 down-modulates the VEGF receptor-2 (VEGFR-2) and p38 mitogen-associated protein kinase phosphorylation induced by VEGF-A165, and this effect was specifically abolished by point mutation at C464. These results identify specific amino acids of the C-terminal cytoplasmic tail of CD36 crucial for the in vitro angiostatic activity of TSP-1 and extend our knowledge of regulation of VEGFR-2-mediated biological activities on ECs.  (+info)

T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. (5/25)

PURPOSE: A carboxyl-terminal fragment of tryptophan tRNA synthetase (T2-TrpRS) has demonstrated potent angiostatic activity during retinal developmental neovascularization in vivo. The effects of T2-TrpRS on pathologic neovascularization were tested and compared with a potent VEGF antagonist using the mouse model of oxygen-induced retinopathy (OIR). METHODS: C57BL/6J mice were transiently exposed to hyperoxic conditions (75% O2) between postnatal day 7 (P7) and P12 and then returned to room air. Retinas were isolated, blood vessels stained with isolectin Griffonia simplicifolia, images of retinal whole-mounts acquired, and the area of vascular obliteration and extent of preretinal neovascularization quantified. This method was compared to the commonly used method of OIR quantification in which the number of pre-inner limiting membrane (ILM) nuclei is counted in serial sections of whole eyes. To assess the angiostatic activity of T2-TrpRS, mice were injected intravitreally at P12 with either T2-TrpRS, a VEGF aptamer, or vehicle (PBS) alone, and the effects on area of obliteration and on preretinal neovascular tuft formation were assessed. RESULTS: Using a modified method of quantification in the mouse OIR model based on images of isolectin-stained retinal wholemounts, we were able to assess reliably and consistently both vascular obliteration and preretinal neovascular tuft formation in the same specimen. T2-TrpRS demonstrated potent angiostatic activity, reducing the appearance of pathologic neovascular tufts by up to 90%. Surprisingly, T2-TrpRS also enhanced physiological revascularization of the obliterated retinal vasculature, reducing these areas by up to 60% compared with PBS-injected eyes. In contrast, the VEGF antagonist, while similarly reducing preretinal neovascular tuft formation, did not enhance revascularization of the obliterated areas. CONCLUSIONS: Use of a rapid, quantifiable method to assess the effect of T2-TrpRS on retinal angiogenesis in the OIR model demonstrates the importance of a quantification system that permits simultaneous analysis of a drug's effect on vascular obliteration as well as on preretinal neovascularization. The results obtained using this method suggest enhanced clinical value for compounds such as T2-TrpRS that not only inhibit pathologic neovascularization, but also facilitate physiological revascularization of ischemic tissue.  (+info)

Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor. (6/25)

Endorepellin, a C-terminal fragment of the vascular basement membrane proteoglycan perlecan, inhibits angiogenesis via the alpha2beta1-integrin receptor. Because this integrin is also implicated in platelet-collagen responses and because endorepellin or its fragments are generated in response to injury and inflammation, we hypothesized that endorepellin could also affect platelet biology. We discovered that endorepellin supported alpha2beta1-dependent platelet adhesion, without appreciably activating or aggregating platelets. Notably, endorepellin enhanced collagen-evoked responses in platelets, in a src kinase-dependent fashion, and enhanced the collagen-inhibitory effect of an alpha2beta1-integrin function-blocking antibody. Collectively, these results suggest that endorepellin/alpha2beta1-integrin interaction and effects are specific and dependent on cell type, differ from those emanated by exposure to collagen, and may be due to cellular differences in alpha2beta1-integrin activation/ligand affinity state. These studies also suggest a heretofore unrecognized role for angiostatic basement membrane fragments in platelet biology.  (+info)

Clinical implications of angiogenesis in cancers. (7/25)

Angiogenesis plays an important role in the growth and progression of cancer. The regulation of tumor angiogenesis depends on a net balance of angiogenic factors and antiangiogenic factors, which are secreted by both tumor cells and host-infiltrating cells. Numerous studies have indicated that assessment of angiogenic activity by either microvessel density or expression of angiogenic factors in cancer can provide prognostic information independent of conventional clinicopathological factors such as tumor staging. Some studies also suggested that assessment of tumor angiogenesis may predict cancer response to chemotherapy or radiotherapy. However, the most important clinical implication of tumor angiogenesis is the development of a novel strategy of anticancer therapy targeting tumor vessels instead of cancer cells. Antiangiogenic therapy aims to inhibit the growth of tumor, and current evidence suggests that it works best in combination with conventional cytotoxic chemotherapy. Recently, a monoclonal antibody against vascular endothelial growth factor, which is one of the most potent angiogenic factors, has been approved for clinical use in colorectal cancer patients after a clinical trial confirmed that combining the antibody with standard chemotherapy regimen could prolong patient survival. The clinical implications of angiogenesis in cancer are reviewed in this article.  (+info)

Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells. (8/25)

Chemokines affect inflammation and cancer through leukocyte attraction and angiogenesis. Here, we demonstrate that CXCL4L1/platelet factor-4 variant (PF-4var), a highly angiostatic chemokine, is poorly chemotactic for phagocytes and is inducible in monocytes by inflammatory mediators but remained undetectable in macrophages and neutrophils. In addition, CXCL4L1/PF-4var production by mesenchymal tumor cells was evidenced in vitro and in vivo by specific ELISA and immunohistochemistry. CXCL4L1/PF-4var, but not CXCL4/PF-4, was coinduced with the angiogenic chemokine CXCL6/granulocyte chemotactic protein-2 (GCP-2) by cytokines, e.g., IL-1beta and IL-17, in sarcoma cells, but not in diploid fibroblasts. Furthermore, the induction of CXCL6/GCP-2 in endothelial cells by IL-1beta was enhanced synergistically by TNF-alpha but inhibited by IFN-gamma, which synergized with IL-1beta to produce the angiostatic CXCL10/IFN-gamma-induced protein-10. These findings indicate that the equilibrium between angiostatic and angiogenic factors during inflammation and tumor progression is rather complex and differs depending on the chemokine, cell type, and stimulus. Selective intervention in the chemokine network may drastically disturb this delicate balance of angiogenesis and tissue repair. Application of angiostatic CXCL4L1/PF-4var without attraction of protumoral phagocytes may be beneficial in cancer therapy.  (+info)

Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
La Jolla, CA-Pfizer Inc. has acquired Angiosyn Inc., a privately held biopharmaceutical company developing an angiostatic agent for ophthalmic diseases, including age-related macular degeneration (AMD).
Abstract Introduction: The role of platelet activation in allergic inflammation is receiving increasing attention. Sublingual immunotherapy for allergic rhinitis can modify the immunological process to an allergen, rather than simply treating symptoms. Objective: The aim of this study was to explore the role of platelet activation during sublingual immunotherapy in children with allergic rhinitis. Methods: Forty-two House Dust Mite - sensitized children with allergic rhinitis were enrolled and received House Dust Mite allergen extract for sublingual immunotherapy or placebo. Serum of different time points during treatment was collected and used for detection of Platelet Factor-4 and Beta-Thromboglobulin concentration by Enzyme-Linked Immuno Sorbent Assay. Results: Our data showed decreased expression of Platelet Factor-4 and Beta-Thromboglobulin protein after one years sublingual immunotherapy. In addition, the decrease of symptom scores and serum Platelet Factor-4 and Beta-Thromboglobulin protein
Berlin Germany: Chemicals that inhibit the development of new blood v...However the researchers warned that the work is still at an early sta...Endometriosis is a disease of the lining tissue of the womb. It can b...Annemiek Nap a doctor at the University Hospital Maastricht The Neth...They used four angiostatic compounds: anti-human vascular endothelial ...,Endometriosis:,Could,angiostatic,therapy,be,the,new,treatment,of,the,future?,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
TY - JOUR. T1 - Fibroblast Growth Factor-2 Antagonist Activity and Angiostatic Capacity of Sulfated Escherichia coli K5 Polysaccharide Derivatives. AU - Leali, Daria. AU - Belleri, Mirella. AU - Urbinati, Chiara. AU - Coltrini, Daniela. AU - Oreste, Pasqua. AU - Zoppetti, Giorgio. AU - Ribatti, Domenico. AU - Rusnati, Marco. AU - Presta, Marco. PY - 2001/10/12. Y1 - 2001/10/12. N2 - The angiogenic basic fibroblast growth factor (FGF2) interacts with tyrosine kinase receptors (FGFRs) and heparan sulfate proteoglycans (HSPGs) in endothelial cells. Here, we report the FGF2 antagonist and antiangiogenic activity of novel sulfated derivatives of the Escherichia coli K5 polysaccharide. K5 polysaccharide was chemically sulfated in N- and/or O-position after N-deacetylation. O-Sulfated and N,O-sulfated K5 derivatives with a low degree and a high degree of sulfation compete with heparin for binding to 125I-FGF2 with different potency. Accordingly, they abrogate the formation of the HSPG-FGF2-FGFR ternary ...
Chemokines belong to a class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. Their name is derived from chemotactic cytokines based on their ability to induce and mediate chemotaxis in nearby responsive cells. Formerly, they were called SIS family of cytokines, SIG family of cytokines, SCY family of cytokines, Platelet factor-4 superfamily or intercrines. Chemokines can be divided into at least four structural branches: c (chemokines, c), cc (chemokines, cc), cx3c (chemokines, cx3c), and cxc (chemokines, cxc). The classification is according to the variations in a shared cysteine motif. Chemokines may also be classified based on their functions. Homeostatic chemokines are chemokines that are responsible for basal leukocyte migration. Examples of homeostatic chemokines are CCL14, CCL19, CCL20, CCL21, CXCL12 and CXCL13. Nevertheless, some of them are not exclusive to this function. For instance, CCL20 is also associated with inflammation since it can act as ...
Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines. Cytokine proteins are classified as chemokines according to behavior and structural characteristics. In addition to being known for mediating chemotaxis, chemokines are all approximately 8-10 kilodaltons in mass and have four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. These proteins have historically been known under several other names including the SIS family of cytokines, SIG family of cytokines, SCY family of cytokines, Platelet factor-4 superfamily or intercrines. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of ...
In the present study, it was demonstrated that IL-17A could stimulate the secretion of angiogenic CXC chemokines from liver cancer cells, which may recruit endothelial cells to the tumor cells in a CXCR2-dependent manner. Tumor angiogenesis was also promoted by IL-17A expression in vivo. The CXC chemokines can be classified as angiogenic or angiostatic predominantly based on the presence or absence of an ELR motif. The angiogenic CXC chemokines include CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL8 and CXCL12, and the angiostatic chemokines include CXCL4, CXCL9, CXCL10, CXCL11 and CXCL14 (21). IL-17A was shown to increase the expression of CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 and CXCL8 in Huh7.5 cells and upregulated CXCL2 in HepG2 cells. Additionally, angiostatic CXC chemokines were not affected by IL-17A in both cell lines. IL-17A has been reported to stimulate VEGFA production and promote angiogenesis in several cancer cell lines (16-18) and it has been shown previously that IL-17A does not affect ...
Cancer cells are often dependent on epigenetic pathways for their survival. Consequently, drugs that target the epigenome, rather than the underlying DNA sequence, are currently attracting considerabl
In the Mouse Antithrombotic Assay aspirin (30-300 mg/kg) protected mice from death by 15 and 42%, respectively. Four Ca++ channel blockers (nitrendipine, nicardipine, nifedipine and verapamil) were effective in reducing the mortality. At the dose of 100 mg/kg nitrendipine and nicardipine gave 80 and 85% protection respectively. Whereas aspirin almost suppressed completely thromboxane (Tx)B2 and platelet factor-4 release after collagen-epinephrine infusion, neither nitrendipine nor nicardipine modified TxB2 release and only reduced slightly platelet factor-4 release. The treatment with aspirin, nitrendipine or nicardipine did not counteract the fall in circulating platelets counted 1 min after the aggregation challenge, but at 3 min platelet count was significantly higher in aspirin-treated mice than in animals given either Ca++ channel blocker. Mouse platelet aggregation induced in vitro by the combination of collagen and epinephrine was inhibited in samples obtained from mice pretreated with ...
To examine whether the lack of sufficient neoangiogenesis in systemic sclerosis (SSc) is caused by a decrease in angiogenic factors and/or an increase in angiostatic factors, the potent proangiogenic molecules vascular endothelial growth factor (VEGF) and basic fibroblast growth factor, and the angiostatic factor endostatin were determined in patients with SSc and in healthy controls. Forty-three patients with established SSc and nine patients with pre-SSc were included in the study. Serum levels of VEGF, basic fibroblast growth factor and endostatin were measured by ELISA. Age-matched and sex-matched healthy volunteers were used as controls. Highly significant differences were found in serum levels of VEGF between SSc patients and healthy controls, whereas no differences could be detected for endostatin and basic fibroblast growth factor. Significantly higher levels of VEGF were detected in patients with Scl-70 autoantibodies and in patients with diffuse SSc. Patients with pre-SSc and short ...
Background: Sepsis-associated disseminated intravascular coagulation (SAC) is associated with marked hemostatic changes including transient thrombocytopenia due to their enodogenous activation / consumption. The widespread activation of platelets contribute to vascular occlusions, fibrin deposition, multi-organ dysfunction, contributing to a two-fold increase in mortality.. Aims: The purpose of this study was to measure markers of platelet function in the plasma of patients with clinically established SAC and to determine their association to disease severity and outcome.. Methods: Plasma samples from 103 adult intensive care unit (ICU) patients with sepsis and suspected disseminated intravascular coagulation (DIC) were acquired from the University of Utah Hospital at the time of admission. Samples were shipped to Loyola University Chicago and stored at -80˚C prior to analysis. Plasma levels of CD40L, von Willebrand Factor (vWF), platelet factor-4 (PF-4), and microparticles (MP) were quantified ...
Neutrophil-activating protein-2 (NAP-2) is a 72 residue protein demonstrating a range of proinflammatory activities. The solution structure of monomeric NAP-2 has been investigated by two-dimensional 1H-n.m.r. spectroscopy. Sequence-specific proton resonance assignments have been made and secondary structural elements have been identified on the basis of nuclear Overhauser data, coupling constants and amide hydrogen/deuteron exchange. The NAP-2 monomer consists of a triple-stranded anti-parallel beta-sheet arranged in a Greek key and a C-terminal helix (residues 59-70) and is very similar to that found in the n.m.r. solution conformation of dimeric interleukin-8 and the crystal structure of tetrameric bovine platelet factor-4. Results are discussed in terms of heparin binding and neutrophil-activation properties of NAP-2. ...
The purpose of this study is to evaluate the efficacy, tolerability and safety of a multi-targeted therapy in patients with hormone-refractory prostate
Multivariate normal distribution theory, correlation and dependence analysis, regression and prediction, dimension-reduction methods, sampling distributions and related inference problems, selected applications in classification theory, multivariate process control, and pattern recognition.. ...
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan. The gene for human PF4 is located on human chromosome 4. Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. PF4 is ...
Background & Aims: It is more important to know which of physical activities could be the most effective way to cause angiogenesis. In this regards, we have investigated an 8-week aerobic training on vascular endothelial growth factor (VEGF) and Endostatin (ES) in sedentary women. Materials & Methods: 20 volunteer inactive women ...
Dr. Maniscalco studies pulmonary microvascular development in lung injury. Using various animal models, including a non-human primate model of BPD, this work examines the effects of oxygen and ventilation of immature lung on the development of alveolar capillaries. The major goals of the research are to characterize microvascular development in lung injury and investigate angiogenic and angiostatic regulators in normal and injured lung. Recent work has linked expression of inflammatory CXC chemokine mediators, which regulate angiogenesis and are part of the pathophysiology of BPD, to impaired lung microangiogenesis. ...
This issue contains an important contribution from the team of Douglas Lauffenburger, Chair of the Editorial Board, at MIT, USA, in which they demonstrate the ability to characterise quantitative data on phenotypic behaviour of individual endothelial cells in response to angiogenesis signalling and relate it to overall population behaviour. They show that the behaviour of microvascular endothelial cells in a single population is heterogeneous and cannot be assumed to be the same for all cells in a given condition.. Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic ...
microRNA-21 (miR-21) is the most commonly upregulated miRNA in solid tumors. This cancer-associated microRNA (oncomiR) regulates various downstream effectors associated with tumor pathogenesis during all stages of carcinogenesis. In this study, we analyzed the function of miR-21 in noncancer cells of the tumor microenvironment to further evaluate its contribution to tumor progression. We report that the expression of miR-21 in cells of the tumor immune infiltrate, and in particular in macrophages, was responsible for promoting tumor growth. Absence of miR-21 expression in tumor- associated macrophages (TAMs), caused a global rewiring of their transcriptional regulatory network that was skewed toward a proinflammatory angiostatic phenotype. This promoted an antitumoral immune response characterized by a macrophage-mediated improvement of cytotoxic T-cell responses through the induction of cytokines and chemokines, including IL-12 and C-X-C motif chemokine 10. These effects translated to a ...
LAA037Ra71, Biotin-Linked Polyclonal Antibody to Fibronectin (FN), 纤连蛋白(FN)多克隆抗体(生物素标记), FN1; CIG; FINC; LETS; MSF; GFND2; Anastellin; Migration-Stimulating Factor; Cold-Insoluble Globulin; Large, External, Transformation-Sensitive Protein | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
RPA037Bo01, Recombinant Fibronectin (FN), 纤连蛋白(FN)重组蛋白, FN1; CIG; FINC; LETS; MSF; GFND2; Anastellin; Migration-Stimulating Factor; Cold-Insoluble Globulin; Large, External, Transformation-Sensitive Protein | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
Treatment of patients with the VEGFR TKIs sorafenib and sunitinib can lead to periods of tumor stability, but resistance to therapy is inevitable. We used a mouse model to define mechanisms by which resistance develops and found that components of the IFNγ signaling pathway are lost with sunitinib or sorafenib therapy. Our data also show that CXCL9 treatment delays resistance to sunitinib in 786-O- and A498-derived tumors and that one mechanism by which this occurs is by prolongation of the antiangiogenic effects of sunitinib. These data suggest that angiostatic pathways are suppressed as a result of VEGFR TKI therapy and set the stage for the subsequent development of resistance to therapy.. In the setting of VEGFR inhibition, RCC tumors undergo extensive necrosis (22). In the setting of this necrosis and accompanying hypoxia/nutrient deprivation, tumors may undergo compensatory changes, including the induction of salvage angiogenesis pathways. We propose that the environmental stress ...
Treatment of metastatic renal cell cancer (RCC) with antiangiogenic agents that block vascular endothelial growth factor (VEGF) receptor 2 signaling produces tumor regression in a substantial fraction of patients; however resistance typically develops within 6-12 months. The purpose of this study was to identify molecular pathways involved in resistance. Treatment of mice bearing either 786-0 or A498 human RCC xenografts with sorafenib or sunitinib produced tumor growth stabilization followed by regrowth despite continued drug administration analogous to the clinical experience. Tumors and plasma were harvested at day 3 of therapy and at the time of resistance to assess pathways that may be involved in resistance. Serial perfusion imaging, and plasma and tumor collections were obtained in mice treated with either placebo or sunitinib alone or in combination with intratumoral injections of the angiostatic chemokine CXCL9. Sunitinib administration led to an early down-modulation of interferon ...
He discovered several angiostatic proteins for potential treatment of cancer. Cao's laboratory discovered catechins in green ...
When mutations occur in the rhodopsin the directional protein movement is affected because the mutations can affect protein ... Many angiostatic factors have been shown to counteract the effect of increasing local VEGF. The naturally occurring form of ... The protein RPE65 is used in the retinoid cycle where the all-trans-retinol within the rod outer segment is isomerized to its ... The opsin proteins are made in the photoreceptor inner segments, then transported to the outer segment, and eventually ...
... matrix protein (M), fusion protein (F), neuraminidase (NA) and large protein (L). All these proteins have variable functions ... regulation of cell growth and mediation of angiostatic effects. Human mast cell infection with SeV induces expression of ... F-protein, as other paramyxoviral fusion proteins, is a trimeric class I viral membrane fusion protein. It is produced in the ... "ASGR1 protein expression summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2020-01-14. "ASGR2 protein ...
... angiostatic proteins MeSH D12.644.276.100.450.500 - angiostatins MeSH D12.644.276.100.450.750 - endostatins MeSH D12.644. ... 14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ... ral gtp-binding proteins MeSH D12.644.360.525.462 - ran gtp-binding protein MeSH D12.644.360.525.475 - rap gtp-binding proteins ... wnt proteins MeSH D12.644.276.996.500 - wnt1 protein MeSH D12.644.276.996.750 - wnt2 protein MeSH D12.644.360.011 - activating ...
... angiostatic proteins MeSH D23.348.479.311.200.500 - angiostatins MeSH D23.348.479.311.200.750 - endostatins MeSH D23.348. ... hiv core protein p24 MeSH D23.050.327.520.330 - hiv envelope protein gp41 MeSH D23.050.327.520.350 - hiv envelope protein gp120 ... adenovirus e1 proteins MeSH D23.050.327.045.060 - adenovirus e2 proteins MeSH D23.050.327.045.070 - adenovirus e3 proteins MeSH ... ldl-receptor related protein 2 MeSH D23.050.422.500.750 - ldl-receptor related protein-associated protein MeSH D23.050.550.325 ...
The regulatory roles and implications of these proteins in human diseases have been largely overlooked for decades. His series ... "A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase". Nature Structural & ... Center for Medicinal Protein Network and Systems Biology 2010-Present Director, Medicinal Bioconvergence Research Center 2000 ... "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". ...
They may use a similar "protein-adduction" mechanism; if so the target protein(s) for these effects have not been defined or ... HPETE is angiostatic and 15(S)-HETE is angiogenic". Inflammation Research. 61 (7): 707-18. doi:10.1007/s00011-012-0463-5. PMID ... 15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 ... Wang, Y; Liang, D; Wang, S; Qiu, Z; Chu, X; Chen, S; Li, L; Nie, X; Zhang, R; Wang, Z; Zhu, D (2010). "Role of the G-protein ...
The HSPG2 gene codes for a 4,391 amino acid protein with a molecular weight of 468,829. It is one of the largest known proteins ... the angiostatic C-terminal fragment of perlecan". J. Biol. Chem. 280 (8): 7080-7. doi:10.1074/jbc.M409841200. PMID 15591058. ... This is not evidence that MMP-2 and MMP-9 directly cleave perlecan protein in vivo but shows that the proteins clearly modulate ... "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J. Biol. Chem. 276 (13): 10263-71. doi: ...
Vascular endothelial growth factor (VEGF) is a type of protein the body cells produce to stimulate the growth of new blood ... angiostatic), or lower the permeability of blood vessels (anti-permeability), in turn curing various eye diseases. Disorders/ ... It is shown to be able to significantly decrease intercellular adhesion molecule-1 mRNA and protein levels and therefore reduce ...
Toxin-chemokine fusion proteins (targeting autoimmune T cells) DT390-CCL5-SRα. EAE. Targeting CCR5+ T cells and attenuating the ... The presence or absence of the ELR motif in CXC chemokines determines the angiogenic (ELR-containing) or angiostatic (non-ELR) ... Coadministration of chemokine with antigen: coadministration of pDNA or recombinant protein encoding chemokines with antigen ... pDNA (CXCL9) + antibody-IL-2 fusion protein (huKS1/4-IL-2). Colon carcinoma CT26-KSA cells. Subcutaneous tumor burden reduction ...
Angiostatic Proteins 22% * Neoplasms 19% * Capillary Permeability 17% * Interferon-gamma 14% * Cyclophosphamide 10% ...
Mei K, Wang L, Tian L, Yu J, Zhang Z and Wei Y: Antitumor efficacy of combination of interferon-gamma-inducible protein 10 gene ... CXCL10 is involved in chemotaxis, induction of apoptosis, regulation of cell growth and mediation of angiostatic effects. ... Kim S, Bakre M, Yin H and Varner JA: Inhibition of endothelial cell survival and angiogenesis by protein kinase A. J Clin ... The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC chemokine family which binds to the CXCR3 ...
... monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, and macrophage inflammatory protein-1β in healthy ... These results are notable due to high levels of IP-10, an angiostatic factor with antifibrotic properties[9]. ... monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α and MIP-1β in HVs and adolescents with MDD ... macrophage inflammatory protein (MIP)-1α, MIP-1β, interleukin (IL)-8, interferon gamma-induced protein (IP)-10, and eotaxin ...
Angiostatic Proteins - Preferred Concept UI. M0442526. Scope note. Proteins that specifically inhibit the growth of new blood ... Proteins that specifically inhibit the growth of new blood vessels (ANGIOGENESIS, PHYSIOLOGIC).. ...
Angiostatic Proteins. Proteínas Angiostáticas. D12 - Aminoácidos, Peptídeos e Proteínas. Bandas Oligoclonais. Oligoclonal Bands ... Cullin Proteins. Proteínas Cullin. Proteínas Ligases SKP Culina F-Box. SKP Cullin F-Box Protein Ligases. Proteínas Ligasas SKP ... F-Box Proteins. Proteínas F-Box. Proteínas Quinases Associadas a Fase S. S-Phase Kinase-Associated Proteins. Proteínas Quinasas ... Photosystem I Protein Complex. Complejo de Proteína del Fotosistema I. Complexo de Proteína do Fotossistema II. Photosystem II ...
... a 50-kD protein with angiostatic and neurotrophic activities that regulates vascular development in the eye. Cosgrove et al. [ ... Keane MP, Belperio JA, Arenberg DA, et al. IFN-γ-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via ... Keane MP, Belperio JA, Moore TA, et al. Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates ... Evidence suggests that the balance between angiogenic and angiostatic CXC chemokines is important in the management and control ...
Among the proteins increased in response to these two kinds of SF, thrombospondin-2 (TSP-2) was specifically increased in only ... TSP-2 shares homology with TSP-1 in primary sequence, structural organization and angiostatic properties. TSP-1-null and TSP-2- ... Endogenous Rspo1 protein was localized to villus epithelium and crypt Paneth cells in mouse small intestine. CONCLUSIONS: Our ... Extracellular matrix proteins participate in the modulation of growth factor response, contribute to the architecture of the ...
Figure 1 Detection of V5-B2 Mannose-binding protein-associated serine protease protein in mosquito cell culture. V5-B2 protein ... Figure 6 Down-regulation of angiogenic factors and up-regulation of angiostatic factors by STAT1-dependent pathway. (A-F) ... While these 12 proteins likely represent proteins that are positively regulated by σB, the other 17 proteins that showed higher ... The B2 protein from the insect-pathogenic FHV is a potent viral suppressor of RNA silencing (VSR) that binds to dsRNA as a ...
Findings Multiple platelet features, including platelet count, volume and protein content, were significantly changed in lung ... trations of the angiogenic proteins VEGF and PDGF,. as well as the angiostatic factors PF4, thrombospondin- ... Findings: Multiple platelet features, including platelet count, volume and protein content,. were significantly changed in lung ... It is known that especially blood platelets, which are the main circulating pool of many bioactive proteins, such as growth ...
A database to provide information about the known and explored therapeutic protein and nucleic acid targets, the targeted ... apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the ... Small-inducible cytokine B10; SCYB10; IP-10; INP10; Gamma-IP10; 10 kDa interferon gamma-induced protein ... binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of ...
In vitro, N-desulfated heparin inhibited significantly bFGF protein and mRNA expression of gastric carcinoma cells (,inline- ... In vitro, N-desulfated heparin inhibited significantly bFGF protein and mRNA expression of gastric carcinoma cells (. ). ... LMW glycol-split heparins may provide the basis for the design of novel nonanticoagulant angiostatic compounds. In addition, it ... S. A. Lang, D. Klein, C. Moser et al., "Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling ...
Angiostatic Proteins. Proteínas Angiostáticas. D12 - Aminoácidos, Peptídeos e Proteínas. Bandas Oligoclonais. Oligoclonal Bands ... Cullin Proteins. Proteínas Cullin. Proteínas Ligases SKP Culina F-Box. SKP Cullin F-Box Protein Ligases. Proteínas Ligasas SKP ... F-Box Proteins. Proteínas F-Box. Proteínas Quinases Associadas a Fase S. S-Phase Kinase-Associated Proteins. Proteínas Quinasas ... Photosystem I Protein Complex. Complejo de Proteína del Fotosistema I. Complexo de Proteína do Fotossistema II. Photosystem II ...
Angiostatic Proteins. Proteínas Angiostáticas. D12 - Aminoacidos, Peptidos y Proteinas. Bandas Oligoclonales. Oligoclonal Bands ... F-Box Proteins. Proteínas F-Box. Proteínas Quinasas Asociadas a Fase-S. S-Phase Kinase-Associated Proteins. Proteínas Quinases ... Cullin Proteins. Proteínas Culina. Proteínas Ligasas SKP Cullina F-box. SKP Cullin F-Box Protein Ligases. Proteínas Ligases SKP ... Photosystem I Protein Complex. Complexo de Proteína do Fotossistema I. Complejo de Proteína del Fotosistema II. Photosystem II ...
Angiostatic Proteins. Proteínas Angiostáticas. D12 - Aminoacidos, Peptidos y Proteinas. Bandas Oligoclonales. Oligoclonal Bands ... F-Box Proteins. Proteínas F-Box. Proteínas Quinasas Asociadas a Fase-S. S-Phase Kinase-Associated Proteins. Proteínas Quinases ... Cullin Proteins. Proteínas Culina. Proteínas Ligasas SKP Cullina F-box. SKP Cullin F-Box Protein Ligases. Proteínas Ligases SKP ... Photosystem I Protein Complex. Complexo de Proteína do Fotossistema I. Complejo de Proteína del Fotosistema II. Photosystem II ...
Angiostatic Proteins. Proteínas Angiostáticas. D12 - Aminoacidos, Peptidos y Proteinas. Bandas Oligoclonales. Oligoclonal Bands ... F-Box Proteins. Proteínas F-Box. Proteínas Quinasas Asociadas a Fase-S. S-Phase Kinase-Associated Proteins. Proteínas Quinases ... Cullin Proteins. Proteínas Culina. Proteínas Ligasas SKP Cullina F-box. SKP Cullin F-Box Protein Ligases. Proteínas Ligases SKP ... Photosystem I Protein Complex. Complexo de Proteína do Fotossistema I. Complejo de Proteína del Fotosistema II. Photosystem II ...
Angiostatic Proteins. Proteínas Angiostáticas. D12 - Aminoacidos, Peptidos y Proteinas. Bandas Oligoclonales. Oligoclonal Bands ... F-Box Proteins. Proteínas F-Box. Proteínas Quinasas Asociadas a Fase-S. S-Phase Kinase-Associated Proteins. Proteínas Quinases ... Cullin Proteins. Proteínas Culina. Proteínas Ligasas SKP Cullina F-box. SKP Cullin F-Box Protein Ligases. Proteínas Ligases SKP ... Photosystem I Protein Complex. Complexo de Proteína do Fotossistema I. Complejo de Proteína del Fotosistema II. Photosystem II ...
Angiostatic Proteins. Proteínas Angiostáticas. Proteínas Angiostáticas. Endostatins. Endostatinas. Endostatinas. Vascular ... F-Box Proteins. Proteínas F-Box. Proteínas F-Box. GTP-Binding Protein beta Subunits. Subunidades beta da Proteína de Ligação a ... Cullin Proteins. Proteínas Culina. Proteínas Cullin. Cytochrome b6f Complex. Complexo Citocromos b6f. Complejo de Citocromo b6f ... GTP-Binding Protein alpha Subunits. Subunidades alfa de Proteína de Ligação a GTP. Subunidades alfa de la Proteína de Enlace a ...
Angiostatic Proteins. Proteínas Angiostáticas. D12 - Aminoácidos, Peptídeos e Proteínas. Bandas Oligoclonais. Oligoclonal Bands ... Cullin Proteins. Proteínas Cullin. Proteínas Ligases SKP Culina F-Box. SKP Cullin F-Box Protein Ligases. Proteínas Ligasas SKP ... F-Box Proteins. Proteínas F-Box. Proteínas Quinases Associadas a Fase S. S-Phase Kinase-Associated Proteins. Proteínas Quinasas ... Photosystem I Protein Complex. Complejo de Proteína del Fotosistema I. Complexo de Proteína do Fotossistema II. Photosystem II ...
Angiostatic Proteins. Proteínas Angiostáticas. Proteínas Angiostáticas. Endostatins. Endostatinas. Endostatinas. Vascular ... F-Box Proteins. Proteínas F-Box. Proteínas F-Box. GTP-Binding Protein beta Subunits. Subunidades beta da Proteína de Ligação a ... Cullin Proteins. Proteínas Culina. Proteínas Cullin. Cytochrome b6f Complex. Complexo Citocromos b6f. Complejo de Citocromo b6f ... GTP-Binding Protein alpha Subunits. Subunidades alfa de Proteína de Ligação a GTP. Subunidades alfa de la Proteína de Enlace a ...
Angiostatic Proteins. Proteínas Angiostáticas. Proteínas Angiostáticas. Endostatins. Endostatinas. Endostatinas. Vascular ... F-Box Proteins. Proteínas F-Box. Proteínas F-Box. GTP-Binding Protein beta Subunits. Subunidades beta da Proteína de Ligação a ... Cullin Proteins. Proteínas Culina. Proteínas Cullin. Cytochrome b6f Complex. Complexo Citocromos b6f. Complejo de Citocromo b6f ... GTP-Binding Protein alpha Subunits. Subunidades alfa de Proteína de Ligação a GTP. Subunidades alfa de la Proteína de Enlace a ...
Angiostatic Proteins. Proteínas Angiostáticas. D12 - Aminoacidos, Peptidos y Proteinas. Bandas Oligoclonales. Oligoclonal Bands ... F-Box Proteins. Proteínas F-Box. Proteínas Quinasas Asociadas a Fase-S. S-Phase Kinase-Associated Proteins. Proteínas Quinases ... Cullin Proteins. Proteínas Culina. Proteínas Ligasas SKP Cullina F-box. SKP Cullin F-Box Protein Ligases. Proteínas Ligases SKP ... Photosystem I Protein Complex. Complexo de Proteína do Fotossistema I. Complejo de Proteína del Fotosistema II. Photosystem II ...
Angiostatic Proteins. Proteínas Angiostáticas. Proteínas Angiostáticas. Endostatins. Endostatinas. Endostatinas. Vascular ... F-Box Proteins. Proteínas F-Box. Proteínas F-Box. GTP-Binding Protein beta Subunits. Subunidades beta da Proteína de Ligação a ... Cullin Proteins. Proteínas Culina. Proteínas Cullin. Cytochrome b6f Complex. Complexo Citocromos b6f. Complejo de Citocromo b6f ... GTP-Binding Protein alpha Subunits. Subunidades alfa de Proteína de Ligação a GTP. Subunidades alfa de la Proteína de Enlace a ...
Angiostatic Proteins. Proteínas Angiostáticas. D12 - Aminoacidos, Peptidos y Proteinas. Bandas Oligoclonales. Oligoclonal Bands ... F-Box Proteins. Proteínas F-Box. Proteínas Quinasas Asociadas a Fase-S. S-Phase Kinase-Associated Proteins. Proteínas Quinases ... Cullin Proteins. Proteínas Culina. Proteínas Ligasas SKP Cullina F-box. SKP Cullin F-Box Protein Ligases. Proteínas Ligases SKP ... Photosystem I Protein Complex. Complexo de Proteína do Fotossistema I. Complejo de Proteína del Fotosistema II. Photosystem II ...
Angiostatic Proteins. Proteínas Angiostáticas. Proteínas Angiostáticas. Endostatins. Endostatinas. Endostatinas. Vascular ... F-Box Proteins. Proteínas F-Box. Proteínas F-Box. GTP-Binding Protein beta Subunits. Subunidades beta da Proteína de Ligação a ... Cullin Proteins. Proteínas Culina. Proteínas Cullin. Cytochrome b6f Complex. Complexo Citocromos b6f. Complejo de Citocromo b6f ... GTP-Binding Protein alpha Subunits. Subunidades alfa de Proteína de Ligação a GTP. Subunidades alfa de la Proteína de Enlace a ...
Angiostatic Proteins. Proteínas Angiostáticas. Proteínas Angiostáticas. Endostatins. Endostatinas. Endostatinas. Vascular ... F-Box Proteins. Proteínas F-Box. Proteínas F-Box. GTP-Binding Protein beta Subunits. Subunidades beta da Proteína de Ligação a ... Cullin Proteins. Proteínas Culina. Proteínas Cullin. Cytochrome b6f Complex. Complexo Citocromos b6f. Complejo de Citocromo b6f ... GTP-Binding Protein alpha Subunits. Subunidades alfa de Proteína de Ligação a GTP. Subunidades alfa de la Proteína de Enlace a ...
The process of angiogenesis depends on the intricate balance between angiogenic and angiostatic factors. We speculated that the ... MicroRNA profiling reveals age-dependent differential expression of nuclear factor kB and mitogen-activated protein kinase in ... p38 mitogen-activated protein kinase downregulates endothelial progenitor cells. Circulation. 2005;111:1184-1191. ... protein, Bmi-1, and FoxO family factors may change ROS level in the cells.27 In bone marrow-derived MSCs obtained from aged ...
It is renowned for its digestive, anti-inflammatory and anti-oxidant properties, its richness in proteins, vitamins, minerals ... It is high protein and high in calories, which gives it a satietogenic power that allows the reduction of snacking cravings, ... Pollen has an angiostatic action; it could constitute an interesting therapeutic agent in the treatment and prevention of ... For example, mice fed pollen expressed less tumor factors and necrotizing proteins in the liver compared to mice on a normal ...
Immunocytochemical studies using a polyclonal antibody to the TK protein demonstrated that the HSV-TK protein was absent in the ... but also release angiostatic molecules. Thus, tumor angiogenesis represents a net balance between positive and negative ... The tumor DNA content, p53 protein expression, proliferating cell nuclear antigen labeling index, and argyrophilic proteins of ... basement membrane 40/secreted protein acidic and rich in cysteine (BM-40/SPARC), an extracellular matrix-associated protein ...
  • Islets were exposed to diabetes-affiliated inflammatory cytokines and changes in protein expression were determined. (bvsalud.org)
  • Aside from its anticoagulant action, heparin binds to various growth factors, cytokines, and extracellular proteins and consequently is able to affect migration of cancer cells and angiogenesis in tumors. (hindawi.com)
  • Cytokines are soluble proteins that mediate cell-to-cell communication. (nature.com)
  • One reason for the difficulties encountered when trying to characterize the integrin family is that many of their ligands are large multi-adhesive extracellular matrix (ECM) molecules that, in addition to binding integrins, bind other proteins including ECM molecules, growth factors, cytokines, and matrix-degrading proteases. (springer.com)
  • It is also possible that fumagillin, an angiostatic agent, affects the synthesis and secretion of cytokines primarily in the vascular compartment of implantation stage endometrium, and thereby manifests differential responses in epithelial, stromal and vascular compartments. (who.int)
  • Furthermore, evidence has emerged regarding an imbalance between angiogenic and angiostatic chemokine levels, leading to an overall angiogenic pattern of expression in both animal models and tissue specimens from IPF patients. (ersjournals.com)
  • Thus, CXC-ELR+ chemokines are angiogenic, even though CXC-ELR- chemokines are angiostatic [36]. (bet-bromodomain.com)
  • Administration of angiogenic growth factors in the form of recombinant protein or by gene transfer to the ischemic animal models has shown to increase nutrient perfusion via neo-vascularization. (frontiersin.org)
  • The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. (spandidos-publications.com)
  • CXCL10 is involved in chemotaxis, induction of apoptosis, regulation of cell growth and mediation of angiostatic effects. (spandidos-publications.com)
  • Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. (idrblab.net)
  • A major role of chemokines is to mediate leukocyte migration through interaction with G-protein-coupled receptors. (medscape.com)
  • Angiostatic Peptide, Endostatin, Predicts Severity in Pediatric Congenital Heart Disease-Associated Pulmonary Hypertension. (cincinnatichildrens.org)
  • The angiostatic peptide endostatin enhances mortality risk prediction in pulmonary arterial hypertension. (cincinnatichildrens.org)
  • Relevant to this, CD47 blocking antibodies and SIRPα fusion proteins are in clinical trials. (bvsalud.org)
  • These second-generation drugs under clinical development include known molecules with novel mechanisms of action, new targets, and fusion proteins that increase half-life and target cytokine activity to the tumour microenvironment or to the desired effector immune cells. (nature.com)
  • Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. (idrblab.net)
  • The selected PDX tissues of the chemotherapy-sensitive group and drug-resistant group were subjected to transcriptome sequencing and protein chip technology to identify the key genes. (bvsalud.org)
  • Despite emerging data obtained from -omics studies, a description of a natural history of atherosclerotic disease in which cell-specific expression of proteins or genes are included is still lacking. (whitepages-com.org)
  • Atherosclerotic plaques are comprised various extracellular matrix proteins, modified lipoprotein particles, and cells of different origins, that is, vascular cells and leukocytes. (whitepages-com.org)
  • These findings suggest unexpected effects on islets from agents that intersect TSP1-CD47-SIRPα.NEW & NOTEWORTHY CD47 is a cell surface receptor with two primary ligands, soluble thrombospondin-1 (TSP1) and cell surface signal regulatory protein alpha (SIRPα). (bvsalud.org)
  • When integrins were being identified with antibodies to integrin β subunits, several proteins were co-immunoprecipitated, and the number of subunits that composed the functional receptors was by no means obvious. (springer.com)
  • In this study, we applied the multivariate statistical tool Partial Least Squares (PLS) to analyze the relative importance of 83 plasma proteins in relation to coronary heart disease (CHD) mortality and the intermediate end points body mass index, HDL-cholesterol and total cholesterol. (tno.nl)
  • TSP1 binds to the cell membrane receptor CD47, which itself engages signal regulatory protein α (SIRPα), and the latter creates a checkpoint for immune activation. (bvsalud.org)
  • Proteins that specifically inhibit the growth of new blood vessels (ANGIOGENESIS, PHYSIOLOGIC). (bvsalud.org)
  • However, results from clinical trials failed to meet the high expectations raised in preclinical models and highlighted the limitations of approaches based on unmodified recombinant proteins. (nature.com)
  • Pediatric pulmonary hypertension: insulin-like growth factor-binding protein 2 is a novel marker associated with disease severity and survival. (cincinnatichildrens.org)
  • Proteolytic cleavage of ECM proteins might also generate fragments with novel biological activity such as endostatin, tumstatin, and endorepellin. (springer.com)
  • Multiple platelet features, including platelet count, volume and protein content, were significantly changed in lung and head of pancreas cancer patients, and a cancer type-specific combination of these platelets features can be used to discriminate between patients with early-stage cancer and healthy individuals. (typeset.io)
  • Findings Multiple platelet features, including platelet count, volume and protein content, were significantly changed in lung and head of pancreas cancer patients. (typeset.io)
  • A class of tyrosine kinase inhibitors (TKI), used as angiostatic compounds, interferes with the ATPase activity of p-glycoprotein, thus impairing its functionality. (springernature.com)
  • Thrombospondin-1 (TSP1) is a secreted protein minimally expressed in health but increased in disease and age. (bvsalud.org)
  • 3. Promising research has found a major protein that builds the cancer's camouflage and targeted immunology offers the possibility of removing it, laying the cancer open to be recognized and attacked by our immune system. (gawlerblog.com)
  • In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. (jefferson.edu)
  • Intercellular signaling peptides and proteins that regulate the proliferation of new bl. (drugbank.com)
  • A tissue- engineered endothelialized dermis to study the modulation of angiogenic and angiostatic Gongjng on capillary-like tube formation in vitro. (allforexindicators.com)
  • Hence, productive angiogenesis depends on the balanced release of angiogenic and angiostatic factors from both malignant and stromal cell types3C7. (bioscinet.org)
  • To determine the temporal expression of vascular growth factors during the lifespan of the primate corpus luteum, experiments were designed to detect mRNA for vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1 and Ang-2 and to localize protein expression for VEGF in macaque luteal tissue during the menstrual cycle. (oregonstate.edu)
  • Therefore, angiostatic factors that counteract VEGF signalling are also required for the formation of functional blood vessels and the prevention of excessive angiogenesis3C5. (bioscinet.org)
  • AST decreased the protein level of VEGF and bFGF in HCT 116 colon cancer cells in a time- and dose-dependent manner. (biomedcentral.com)
  • In the tumor tissues excised from AST-treated animals, protein level of p-Akt, p-mTOR, VEGF, VEGFR1 and VEGFR2 was down-regulated. (biomedcentral.com)
  • Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. (peprotech.com)
  • The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity. (vanderbilt.edu)
  • Recently discovered endogenously produced angiostatic proteins are vasostatin [ 75 ] and restin, [ 76 ] but their detailed mechanism of action is yet to be discovered. (medscape.com)
  • A number of herpes- and poxviruses encode 7TM G-protein coupled receptors most of which clearly are derived from their host chemokine system as well as induce high expression of certain 7TM receptors in the infected cells. (nih.gov)
  • Dynamic expression of angiogenic/angiostatic factors appears critical for development, maintenance and regression of the luteal microvasculature during the menstrual cycle. (oregonstate.edu)
  • Cell lineages especially important to the immune response include two classes of lymphocytes: B-cells, which can produce and secrete immunoglobulins (proteins with the capability of recognizing and binding to foreign matter to effect its removal), and T-cells of various subsets that secrete lymphokines and induce or suppress the B-cells and various other cells (including other T-cells) making up the immune network. (justia.com)
  • We have found that when the protein linked to this disease, survival motor neuron protein (SMN), is decreased motoneurons exhibit aberrant axonal development, decreased axonal actin dynamics, and decreased dendrites. (zfin.org)
  • Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis. (medscape.com)
  • The present invention pertains to compositions related to proteins which function in controlling biology and physiology of mammalian cells, e.g., cells of a mammalian immune system. (justia.com)
  • This study was aimed at obtaining a profile of lipids and proteins with a paracrine function in normal and diabetic vitreous and exploring whether the profile correlates with retinal pathology. (diabetesjournals.org)
  • However, as a protein reagent, endostatin can only function for a short time and thus is not suitable for a recurrent disease such as endometriosis. (hindawi.com)
  • This study is the first to demonstrate diabetes-specific changes in vitreous lipid autacoids including arachidonate and docosahexanoate-derived metabolites indicating an increase in inflammatory versus anti-inflammatory lipid mediators that correlated with increased levels of inflammatory and angiogenic proteins, further supporting the notion that inflammation plays a role the pathogenesis of this disease. (diabetesjournals.org)
  • Conversely, CS-ASC secreted the angiostatic/pro-inflammatory factor Activin A, which was not detected in nCS-ASC conditioned media (CM). Furthermore, higher Activin A levels were measured in EC/CS-ASC cocultures than in EC/nCS-ASC cocultures. (bvsalud.org)
  • A family of structurally-related angiogenic proteins of approximately 70 kDa in size. (umassmed.edu)
  • Contusion injury of the spinal cord was performed using a New York University impactor at the ninth thoracic vertebrae, followed by intrathecal injection of 15 μg recombinant protein comprising DcR3 (DcR3.Fc) in 5 μl of normal saline as the treatment, or 5 μl of normal saline as the control, into the injury epicenter. (biomedcentral.com)