Angiopoietins: A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.Angiopoietin-2: An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.Angiopoietin-1: The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.Receptor, TIE-2: A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).Receptor, TIE-1: A TIE receptor found predominantly on ENDOTHELIAL CELLS. It is considered essential for vascular development and can form a heterodimer with the TIE-2 RECEPTOR. The TIE-1 receptor may play a role in regulating BLOOD VESSEL stability and maturation.Receptors, TIE: A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Neovascularization, Physiologic: The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.Angiogenesis Inducing Agents: Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.Vascular Endothelial Growth Factors: A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Endothelial Growth Factors: These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.Receptor Protein-Tyrosine Kinases: A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.Lymphokines: Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Intercellular Signaling Peptides and Proteins: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.Blood Vessels: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Vascular Endothelial Growth Factor Receptor-1: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Biological Factors: Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Health Knowledge, Attitudes, Practice: Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Glycocalyx: The carbohydrate-rich zone on the cell surface. This zone can be visualized by a variety of stains as well as by its affinity for lectins. Although most of the carbohydrate is attached to intrinsic plasma membrane molecules, the glycocalyx usually also contains both glycoproteins and proteoglycans that have been secreted into the extracellular space and then adsorbed onto the cell surface. (Alberts et al., Molecular Biology of the Cell, 3d ed, p502)Reperfusion Injury: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Capillary Permeability: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.Lipoprotein Lipase: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.TriglyceridesRenal Dialysis: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Liver Regeneration: Repair or renewal of hepatic tissue.Cell-Derived Microparticles: Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Coronary Vessels: The veins and arteries of the HEART.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Chest Pain: Pressure, burning, or numbness in the chest.

Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (1/298)

Using homology-based PCR, we have isolated cDNA encoding a novel member (491 amino acids) of the angiopoietin (Ang) family from human adult heart cDNA and have designated it angiopoietin-3 (Ang3). The NH2-terminal and COOH-terminal portions of Ang-3 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in other known Angs. Ang3 has a highly hydrophobic region at the N-terminus (approximately 21 amino acids) that is typical of a signal sequence for protein secretion. Ang3 mRNA is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine in human adult tissues. Additionally, Ang3 is a secretory protein, but is not a mitogen in endothelial cells.  (+info)

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (2/298)

The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist, angiopoietin-2, both of which act by means of the Tie2 receptor. We now report our attempts to use homology-based cloning approaches to identify new members of the angiopoietin family. These efforts have led to the identification of two new angiopoietins, angiopoietin-3 in mouse and angiopoietin-4 in human; we have also identified several more distantly related sequences that do not seem to be true angiopoietins, in that they do not bind to the Tie receptors. Although angiopoietin-3 and angiopoietin-4 are strikingly more structurally diverged from each other than are the mouse and human versions of angiopoietin-1 and angiopoietin-2, they appear to represent the mouse and human counterparts of the same gene locus, as revealed in our chromosomal localization studies of all of the angiopoietins in mouse and human. The structural divergence of angiopoietin-3 and angiopoietin-4 appears to underlie diverging functions of these counterparts. Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist.  (+info)

Angiopoietin-3, a novel member of the angiopoietin family. (3/298)

A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2.  (+info)

Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. (4/298)

Using degenerate polymerase chain reaction, we isolated a cDNA encoding a novel 493-amino acid protein from human and mouse adult heart cDNAs and have designated it angiopoietin-related protein-2 (ARP2). The NH(2)-terminal and COOH-terminal portions of ARP2 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in angiopoietins. ARP2 has two consensus glycosylation sites and a highly hydrophobic region at the NH(2) terminus that is typical of a secretory signal sequence. Recombinant ARP2 expressed in COS cells is secreted and glycosylated. In human adult tissues, ARP2 mRNA is most abundant in heart, small intestine, spleen, and stomach. In rat embryos, ARP2 mRNA is most abundant in the blood vessels and skeletal muscles. Endothelial and vascular smooth muscle cells also contain ARP2 mRNA. Recombinant ARP2 protein induces sprouting in vascular endothelial cells but does not bind to the Tie1 or Tie2 receptor. These results suggest that ARP2 may exert a function on endothelial cells through autocrine or paracrine action.  (+info)

Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (5/298)

Using degenerate PCR we isolated a cDNA encoding a novel 406- and 410-amino acid protein from human and mouse embryonic cDNAs and have designated it 'hepatic fibrinogen/angiopoietin-related protein' (HFARP). The N-terminal and C-terminal portions of HFARP contain the characteristic coiled-coil domains and fibrinogen-like domains that are conserved in angiopoietins. In human and mouse tissues, HFARP mRNA is specifically expressed in the liver. HFARP mRNA and protein are mainly present in the hepatocytes. HFARP has a highly hydrophobic region at the N-terminus that is typical of a secretory signal sequence and one consensus glycosylation site. Recombinant HFARP expressed in COS-7 cells is secreted and glycosylated. HFARP protein is present not only in the hepatocytes, but also in the circulating blood. Recombinant HFARP acts as an apoptosis survival factor for vascular endothelial cells, but does not bind to Tie1 or Tie2 (endothelial-cell tyrosine kinase receptors). These results suggest that HFARP may exert a protective function on endothelial cells through an endocrine action.  (+info)

Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. (6/298)

The angiopoietins are recently described growth factors for vascular endothelium. The Tie1 and Tie2 receptors are expressed by endothelium. Acquired immune deficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS) and cutaneous angiosarcoma are malignancies of endothelial origin. KS involves primarily the skin and mucosal surfaces and is common in AIDS patients. In an effort to determine whether the angiopoietins and Tie receptors play a role in the pathobiology of angiosarcoma and KS, we studied the expression of angiopoietin-1, angiopoietin-2, angiopoietin-4, Tie1, and Tie2 mRNAs in biopsies of KS from 12 AIDS patients, in biopsies of cutaneous angiosarcoma from two patients, and in control biopsies of normal skin from three volunteers by in situ hybridization. Strong expression of angiopoietin-2, Tie1, and Tie2 mRNAs was detected in the tumor cells of KS and cutaneous angiosarcomas, in contrast to the focal low-level expression in normal skin biopsies. Focal low-level expression of angiopoietin-1 was seen in KS, cutaneous angiosarcomas, and in normal skin. Focal low-level expression of angiopoietin-4 was identified in a minority of KS lesions. These findings suggest that the angiopoietins and Tie receptors may play an important role in the pathobiology of KS and cutaneous angiosarcoma and identify additional potential targets for therapeutic intervention in these vascular malignancies.  (+info)

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. (7/298)

Fasting is associated with significant changes in nutrient metabolism, many of which are governed by transcription factors that regulate the expression of rate-limiting enzymes. One factor that plays an important role in the metabolic response to fasting is the peroxisome proliferator-activated receptor alpha (PPARalpha). To gain more insight into the role of PPARalpha during fasting, and into the regulation of metabolism during fasting in general, a search for unknown PPARalpha target genes was performed. Using subtractive hybridization (SABRE) comparing liver mRNA from wild-type and PPARalpha null mice, we isolated a novel PPARalpha target gene, encoding the secreted protein FIAF (for fasting induced adipose factor), that belongs to the family of fibrinogen/angiopoietin-like proteins. FIAF is predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. Moreover, FIAF mRNA is decreased in white adipose tissue of PPARgamma +/- mice. FIAF protein can be detected in various tissues and in blood plasma, suggesting that FIAF has an endocrine function. Its plasma abundance is increased by fasting and decreased by chronic high fat feeding. The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions.  (+info)

Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (8/298)

The nuclear receptor peroxisome proliferator-activated receptor gamma regulates adipose differentiation and systemic insulin signaling via ligand-dependent transcriptional activation of target genes. However, the identities of the biologically relevant target genes are largely unknown. Here we describe the isolation and characterization of a novel target gene induced by PPARgamma ligands, termed PGAR (for PPARgamma angiopoietin related), which encodes a novel member of the angiopoietin family of secreted proteins. The transcriptional induction of PGAR follows a rapid time course typical of immediate-early genes and occurs in the absence of protein synthesis. The expression of PGAR is predominantly localized to adipose tissues and placenta and is consistently elevated in genetic models of obesity. Hormone-dependent adipocyte differentiation coincides with a dramatic early induction of the PGAR transcript. Alterations in nutrition and leptin administration are found to modulate the PGAR expression in vivo. Taken together, these data suggest a possible role for PGAR in the regulation of systemic lipid metabolism or glucose homeostasis.  (+info)

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Angiopoietin-like protein 3(ANGPTL3) is well acknowledged as a key regulator of lipid metabolism. Now, there have not been enough data to explain the mechanism of hyperlipidemia related proteinuria. In this study, we hoped to investigate the changes of Angiopoietin-like protein 3(ANGPTL3) levels in hyperlipidemia patients with different proteinuria levels. Seventy-one patients with hyperlipidemia were selected, who were hospitalized in Gansu Provincial Peoples Hospital from September 2016 to September 2017, and 20 healthy people in the physical examination center were selected. We combed through medical history and conducted clinical biochemical indicators of blood urea nitrogen (BUN), serum creatinine (SCr), 24 h urine protein quantitation (24hUPro), cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low detection of density lipoproteins (LDL-C). The concentration of serum ANGPTL3 was measured by ELISA. 1. Serum ANGPTL3 in patients with hyperlipidemia related proteinuria was
Shop Angiopoietin-like protein ELISA Kit, Recombinant Protein and Angiopoietin-like protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene. Angiopoietin-like protein 2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas an excess of ANGPTL2 activation induced by prolonged stress promotes the breakdown of tissue homeostasis due to chronic inflammation, promoting the development of metabolic diseases. ANGPTL2 has a role also in angiogenesis, in tissue repair, in obesity, in atherosclerotic diseases and finally in cancerogenesis. Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. GRCh38: ...
Lipoprotein lipase (LPL) hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue. LPL in macrophages in the artery wall may, however, promote foam cell formation and atherosclerosis. Angiopoietin-like protein (ANGPTL) 4 inactivates LPL and ANGPTL4 expression is controlled by peroxisome proliferator-activated receptors (PPAR). The mechanisms for inactivation of LPL by ANGPTL4 was studied in THP-1 macrophages where active LPL is associated with cell surfaces in a heparin-releasable form, while LPL in the culture medium is mostly inactive. The PPAR delta agonist GW501516 had no effect on LPL mRNA, but increased ANGPTL4 mRNA and caused a marked reduction of the heparin-releasable LPL activity concomitantly with accumulation of inactive, monomeric LPL in the medium. Intracellular ANGPTL4 was monomeric, while dimers and tetramers of ANGPTL4 were present in the heparin-releasable fraction and medium. GW501516 caused an increase ...
Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA expression of the anti-apoptotic BCL-2 family
Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin β1 signaling in human hepatocellular ...
Angiopoietin-related protein 4 (406 aa, ~45 kDa) is encoded by the human ANGPTL4 gene. This protein plays a role in the modulation of signaling during hypoxic stress and angiogenesis.
Chronic vascular inflammation in coronary artery plays crucial roles in pathogenesis of coronary artery disease (CAD) through causing endothelial dysfunction and the progression of coronary atherosclerosis. Recently, we reported that adipose tissue-derived Angptl2 is a key mediator linking obesity to adipose tissue inflammation and systemic insulin resistance (Cell Metabolism 2009). Since angptl2 is also secreted from endothelial cells, and promotes vascular inflammation via the integrin α5β1/Rac1/NF-κB pathway, we investigated whether Angptl2 cause the coronary endothelial dysfunction and atherosclerosis in CAD. First, we compared circulating Angptl2 levels in 83 subjects with coronary endothelial dysfunction (CED) and 30 subjects with chest pain syndrome (CPS) of normal coronary endothelial function. We assessed coronary endothelial function by estimating the ratio of coronary blood flow in response to intracoronary injection of acetylcholine (ACh). Plasma Angptl2 concentrations were ...
Rabbit Polyclonal Anti-Angiopoietin-like Protein 5/ANGPTL5 Antibody. Validated: WB, ELISA. Tested Reactivity: Human. 100% Guaranteed.
Principal Investigator:KAGAMI Shoji, Project Period (FY):2011 - 2013, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Pediatrics
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
Sigma-Aldrich offers abstracts and full-text articles by [Dana Mahmood, Elena Makoveichuk, Solveig Nilsson, Gunilla Olivecrona, Bernd Stegmayr].
The fasting-induced adipose factor (FIAF, ANGPTL4, PGAR, HFARP) was previously identified as a novel adipocytokine that was up-regulated by fasting, by peroxisome proliferator-activated receptor agonists, and by hypoxia. To further characterize FIAF, we studied regulation of FIAF mRNA and protein in liver and adipose cell lines as well as in human and mouse plasma. Expression of FIAF mRNA was up-regulated by peroxisome proliferator-activated receptor α (PPARα) and PPARβ/δ agonists in rat and human hepatoma cell lines and by PPARγ and PPARβ/δ agonists in mouse and human adipocytes. Transactivation, chromatin immunoprecipitation, and gel shift experiments identified a functional PPAR response element within intron 3 of the FIAF gene. At the protein level, in human and mouse blood plasma, FIAF was found to be present both as the native protein and in a truncated form. Differentiation of mouse 3T3-L1 adipocytes was associated with the production of truncated FIAF, whereas in human white ...
Effective slimming actives should reduce lipogenesis, increase lipolysis, promote fatty acid release and improve skin firmness. Here, the authors describe the development of such an active based on polyglucuronic acid. Further, this material is shown to act on a new biological pathway involving the fasting-induced adipose factor (FIAF) adipokine.
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Objective: Lipoprotein lipase (LPL) is a key regulator of circulating triglyceride rich lipoprotein hydrolysis. In brain LPL regulates appetite and energy expenditure. Angiopoietin-like 4 (Angptl4) is a secreted protein that inhibits LPL activity and, thereby, triglyceride metabolism, but the impact of Angptl4 on central lipid metabolism is unknown. Methods: We induced type 1 diabetes by streptozotocin (STZ) in whole-body Angptl4 knockout mice (Angptl4-/-) and their wildtype littermates to study the role of Angptl4 in central lipid metabolism. Results: In type 1 (streptozotocin, STZ) and type 2 (ob/ob) diabetic mice, there is a ~2-fold increase of Angptl4 in the hypothalamus and skeletal muscle. Intracerebroventricular insulin injection into STZ mice at levels which have no effect on plasma glucose restores Angptl4 expression in hypothalamus. Isolation of cells from the brain reveals that Angptl4 is produced in glia, whereas LPL is present in both glia and neurons. Consistent with the in vivo ...
Objective: Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development. Approach and Results: Macrophage activation elicited by pathogen-recognition receptor agonists decreased Angptl4 expression, whereas lipid loading by intralipid and oxidized low-density lipoprotein increased Angptl4 expression. Consistent with an antilipotoxic role of Angptl4, recombinant Angptl4 significantly decreased uptake of oxidized low-density lipoprotein by macrophages, via lipolysis-dependent and -independent mechanisms. Angptl4 protein was detectable in human atherosclerotic lesions and localized to macrophages. Transgenic overexpression of Angptl4 in atherosclerosis-prone ...
The ANGPTL4 Human Recombinant is manufactured with C-terminal fusion of 11 amino acid FLAG Tag. The ANGPTL4 Flag -Tagged Fusion Protein is a 44.2kDa protein containing 392 amino acid residues of the Angiopoietin-like Protein 4 and 11 additional amin
Model of tumor cell resistance to antineoplastic therapy through angiopoietin-like protein 2 (ANGPTL2) expression. Tumor cell-secreted ANGPTL2 induces spleen ty
The angiopoietin-like protein ANGPTL8 (A8) is one of three ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is expressed in liver and adipose tissue, is required to redirect dietary TG from oxidative to storage tissues following food intake. Here we show that A8 from liver and adipose tissue have different roles in this process. Mice lacking hepatic A8 have no circulating A8, high intravascular LPL activity, low plasma TG levels, and evidence of decreased delivery of dietary lipids to adipose tissue. In contrast, mice lacking A8 in adipose tissue have higher postprandial TG levels and no alteration in fatty acid composition in adipocytes. Expression of A8, together with A4, in cultured cells reduced A4 secretion and A4-mediated LPL inhibition. Thus, hepatic A8 (with A3) acts in an endocrine fashion to inhibit intravascular LPL in oxidative tissues, ...
LPL is a key regulator of fatty acid release from triglyceride-rich lipoproteins in muscle, heart, and fat (22). Increased adipocyte LPL activity leads to increased cellular uptake of fatty acids and adipocyte triglyceride accumulation. In white fat, LPL is regulated posttranscriptionally by nutritional status: fasting reduces and refeeding increases enzyme activity (23). Intriguingly, we found that a 14-d conventionalization increased LPL activity 122% in epididymal fat pads (Fig. 4C ). Moreover, the effect was not confined to fat: enzymatic assays of heart revealed a 99% increase with conventionalization (Fig. 4C ). Increased insulin levels produce reductions in muscle LPL activity (24). Therefore, our findings indicated that the microbiota induces the observed general increase in LPL through another mechanism.. Fiaf, also known as angiopoietin-like protein 4, is produced by brown and white fat, liver, and intestine (13, 25, 26). This secreted protein is an inhibitor of LPL in vitro [IC50 = ...
Podocyte injury plays central roles in proteinuria and kidney dysfunction, therefore, identifying specific biomarker to evaluate earlier podocyte injury is highly desirable. Podocyte-secreted angiopoietin-like-4 (Angptl4) mediates proteinuria in different types of podocytopathy. In the present study …
The majority of patients with diabetic macular edema (DME), the most common cause of vision loss in working-age Americans, do not respond adequately to current therapies targeting VEGFA. Here, we show that expression of angiopoietin-like 4 (ANGPTL4), a HIF-1-regulated gene product, is increased in the eyes of diabetic mice and patients with DME. We observed that ANGPTL4 and VEGF act synergistically to destabilize the retinal vascular barrier. Interestingly, while ANGPTL4 modestly enhanced tyrosine phosphorylation of VEGF receptor 2, promotion of vascular permeability by ANGPTL4 was independent of this receptor. Instead, we found that ANGPTL4 binds directly to neuropilin 1 (NRP1) and NRP2 on endothelial cells (ECs), leading to rapid activation of the RhoA/ROCK signaling pathway and breakdown of EC-EC junctions. Treatment with a soluble fragment of NRP1 (sNRP1) prevented ANGPTL4 from binding to NRP1 and blocked ANGPTL4-induced activation of RhoA as well as EC permeability in vitro and retinal ...
Previously, I discussed how important gut microbiota is in disease condition and how it may contribute to TLR4 signaling pathway. In todays post, I will discuss how gut microbiome can affect lipid metabolism.. Several studies supported a role for gut microbiota in the modulation of lipid metabolism1-3. In one of the early studies on this topic, Jeffrey Gordon group were able to show that conventialization of adult GF C57BL/6 mice with a normal microbiota resulted in a 60% increase in body fat content despite reduced food intake2. Further, they were able to demonstrate that Fasting-induced adipocyte factor (Fiaf) - also known as Angiopoietin-like 4 (ANGPTL4), a member of angiopoietin-like family of proteins, is suppressed in the intestine of normal mice after conventialization2. Their data from fiaf -/- mice also revealed that Fiaf is a LPL inhibitor and its suppression is needed for gut microbiota-induced deposition of triglyceride in adipose tissue. Continuing to further support the merging ...
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ANGPTL4 - ANGPTL4 (Myc-DDK-tagged)-Human angiopoietin-like 4 (ANGPTL4), transcript variant 3 available for purchase from OriGene - Your Gene Company.
Angptl4 - Angptl4 (Myc-DDK-tagged ORF) - Rat angiopoietin-like 4 (Angptl4), (10 ug) available for purchase from OriGene - Your Gene Company.
The aim of the present study was to examine the association of angiopoietin-like proteins-8 (ANGPTL8) rs2278426, cholesteryl ester-transfer protein (CETP) rs708272 and endothelial nitric oxide synthase (NOS3) rs1799983 variants with type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), and to investigate the effect of the potential interaction between these variants on disease risk. Our study included 272 subjects classified into 68 patients with T2DM, 68 patients with T2DM complicated with CVD and 136 control subjects. ANGPTL8 c194C|T, CETP Taq1B and NOS3 G894T polymorphisms were genotyped using TaqMan® SNP Genotyping Assay. The presence of NOS3, ANGPTL8, and homozygous CETP B1 variants were associated with increased risk of T2DM by 3.07-, 2.33- and 1.75-fold, respectively. NOS3 variant was associated with 3.08-fold increased risk of CVD (95% CI 1.70-5.60), while ANGPTL8 C allele was associated with 2.8-fold increased risk of CVD in T2DM patients (95% CI 1.13-6.97). Concomitant presence of
The angiopoietin-like 4 (ANGPLT4) protein is involved in lipid metabolism and is known to inhibit lipoprotein lipase in the bloodstream. We investigated the effect of milk on intestinal ANGPTL4 and the metabolic profile of growing pigs and the effect of free fatty acids (FFAs) on ANGPTL4 in ex vivo and in vitro assays. Feeding pigs whole milk increased intestinal ANGPTL4 mRNA and increased fecal excretion of long-chain FFA compared to the control group fed soybean oil (n = 9). Furthermore, FFAs (C4-C8) induced ANGPTL4 gene expression in porcine intestinal tissue mounted in Ussing chambers and ANGPTL4 protein secretion to both the apical and basolateral sides of intestinal Caco-2 cells on permeable membranes ...
Rabbit polyclonal antibody raised against a full-length human ANGPTL3 protein. ANGPTL3 (NP_055310.1, 1 a.a. ~ 460 a.a) full-length human protein. (H00027329-D01P) - Products - Abnova
Targeting the blood-vessel-growth protein angiopoietin-like 4 (ANGPTL4) along with anti-vascular endothelial growth factor (VEGF) therapy could increase the effectiveness of treatments for the prevention of proliferative diabetic retinopathy (PDR), according to researchers at The Johns Hopkins University and the University of Maryland.
We are using a multidisciplinary approach combining gene discovery approach for complex human diseases, vascular cell biology (endothelial and smooth muscle cells) cell cultures in 2-D and 3-D, biochemistry, molecular biology, various imaging approaches (confocal analyses, videomicroscopy), gene expression analyses, protein production, and preclinical models of human diseases. Our efforts have recently been focused on characterizing the role of Thrombospondin-1, Angiopoietin-like 4 and Lysysl Oxidase like 2 in regulating angiogenesis and vascular integrity.. By gain-of-function and loss-of-function approaches, both in vitro and in vivo, we are also studying ECM composition, deposition, posttranslational modifications and rearrangement by ECs. Indeed, hypoxia-driven vascular remodeling is dynamically regulated through activities of ECM modifying enzyme, such as Lysysl Oxidase like 2 or Transgluaminase-2 that eventually regulate both matricellular proteins and growth factor availability, that ...
Human ANGPTL3 partial ORF ( NP_055310.1, 361 a.a. - 460 a.a.) recombinant protein with GST-tag at N-terminal. (H00027329-Q01) - Products - Abnova
La dérégulation de la formation et lintégrité des vaisseaux sanguins peut conduire à un état pathologique tel quobservé dans de nombreuses maladies ischémiques telles que: la croissance de tumeur solide, larthrite rhumatoïde, le psoriasis, les rétinopathies et lathérosclérose. Par conséquent, la possibilité de moduler langiogenèse régionale chez les patients souffrant dischémie est cliniquement pertinente. Un élément clé dans linduction de langiogenèse pathologique est une inflammation qui précède et accompagne la formation des nouveaux vaisseaux. Ce phénomène est démontré par laugmentation de la perméabilité vasculaire et le recrutement de monocytes/ macrophages et cellules polynucléaires (neutrophiles). En collaboration avec dautres groupes, nous avons montré que différents facteurs de croissance tels que le facteur de croissance endothélial vasculaire et les angiopoïétines peuvent non seulement promouvoir langiogenèse mais aussi induire diverses ...
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The siRNA ARO-ANG3 directed at ANGPTL3 gave durable lowering of ANGPTL3, TG, VLDL-c, LDL-c and HDL-c up to 16 weeks after a single dose, with a good safety profile.
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Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor. Since differentiation can attenuate or halt the growth of tumor cells, an image-based phenotypic screening was performed to find out drugs inducing morphological differentiation of GBMs. Bexarotene, a selective retinoid X receptor agonist, showed strong inhibition of neurospheroidal colony formation and migration of cultured primary GBM cells. Bexarotene treatment reduced nestin expression, while significantly increasing glial fibrillary acidic protein (GFAP) expression. The effect of bexarotene on gene expression profile was compared with the activity of all-trans retinoic acid (ATRA), a well-known differentiation inducer. Both drugs largely altered the gene expression pattern into a tumor-ameliorating direction. These drugs increased the gene expression levels of Kruppel-like factor 9 (KLF9), regulator of G-protein signaling 4 (RGS4), growth differentiation factor 15 (GDF15), angiopoietin-like protein 4 (ANGPTL4), and ...
Detect and quantitate human angiopoietin-like 3 protein (ANGPTL3) in buffered solution and cell culture supernatants using a homogeneous LANCE Ultra TR-FRET assay.
Detect and quantitate human angiopoietin-like 3 protein (ANGPTL3) in buffered solution and cell culture supernatants using a homogeneous LANCE Ultra TR-FRET assay.
Expression of ANGPTL2 (ARP2, HARP) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
ANGPTL7 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 324 amino acids (22-337 a.a.) and having a molecular mass of 37.5kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin 2. antagonist of angiopoietin 1. TSP-1 and TSP-2. inhibit cell migration, cell proliferation, cell adhesion and ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Activation of the Tie2 receptor by the ligand Angiopoietin 2. This has been shown in vitro and in vivo. Activation of the ... Activation of the signaling pathway by Delta4, Angiopoietin 2, insulin, or a combination of the three and a JAK inhibitor ... Angiopoietin 2). Hes3, in turn, by regulating the expression of Shh and potentially other factors, can also exert an effect on ... Angiopoietin 2, insulin, or a combined treatment consisting of all three factors and an inhibitor of JAK) induce the increase ...
Li, J. J.; Huang, Y. Q.; Basch, R.; Karpatkin, S. (February 2001). "Thrombin induces the release of angiopoietin-1 from ... Angiopoietin-1[53]) and cytokines including the EMT inducer TGF-β.[54] The release of TGF-β by platelets in blood vessels near ...
Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene. Angiopoietins are proteins with important roles in ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3-4): 147-54. ... "Entrez Gene: ANGPT4 angiopoietin 4". Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser. ...
"Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 ... Li L, Chong HC, Ng SY, Kwok KW, Teo Z, Tan EH, Choo CC, Seet JE, Choi HW, Buist ML, Chow VT, Tan NS (2015). "Angiopoietin-like ... Xu A, Lam MC, Chan KW, Wang Y, Zhang J, Hoo RL, Xu JY, Chen B, Chow WS, Tso AW, Lam KS (2005). "Angiopoietin-like protein 4 ... Chong HC, Chan JS, Goh CQ, Gounko NV, Luo B, Wang X, Foo S, Wong MT, Choong C, Kersten S, Tan NS (2014). "Angiopoietin-like 4 ...
Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene. The protein encoded by ... The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced ... 2003). "Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes". Biochem. Biophys. Res. ... 2003). "Regulation of the angiopoietin-like protein 3 gene by LXR". J. Lipid Res. 44 (1): 136-43. doi:10.1194/jlr.M200367- ...
It targets the protein angiopoietin 2. As of May 2017[update], it is in Phase II clinical trials for the treatment of diabetic ... "Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of ...
Angiopoietin (Ang). *Autocrine motility factor. *Bone morphogenetic proteins (BMPs). *Ciliary neurotrophic factor family * ...
"Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization". Circulation Research. 83 (3): 233-40. ... Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the ... Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (Nov 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent ...
Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 ... Xu Y, Yu Q (September 2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its ... "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... similar to angiopoietin-1 See Angiopoietin#Clinical_relevance ANGPT2 has been shown to interact with TEK tyrosine kinase. ...
ANGPTL1: Angiopoietin-related protein 1. *ARHGEF2 (1q22). *ARID4B: encoding protein AT-rich interactive domain-containing ...
The angiopoietins, Ang1 and Ang2, are required for the formation of mature blood vessels, as demonstrated by mouse knock out ... Thurston G (October 2003). "Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis". ...
Angiopoietin-2 works with VEGF to facilitate cell proliferation and migration of endothelial cells ...
Also, angiopoietin 2 can act as an antagonist to Tie-2. This destabilizes the endothelial cells, which accounts for less ... Angiopoietin 1 and Tie-2 signaling is essential for maturation and stabilization of endothelial cells. Platelet-derived growth ... Similar to the inhibition of the PDGF pathway, angiopoietin 2 reduces levels of pericytes, leading to diabetic retinopathy. ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...
Chugh, S; Macé, C; Clement, L; Del Nogal, A; Marshall, C (2014). "Angiopoietin-like 4 based therapeutics for proteinuria and ...
Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription. Cell 2006; 124, 275-286 Abstract ...
Browse our Angiopoietin-like Protein 1/ANGPTL1 Protein catalog backed by our Guarantee+. ... Angiopoietin-like Protein 1/ANGPTL1 Proteins available through Novus Biologicals. ... angiopoietin Y1 protein, angiopoietin-3 protein, angiopoietin-like 1 protein, Angiopoietin-like protein 1 protein, angiopoietin ... Angiopoietin-like Protein 1/ANGPTL1 Proteins. We offer Angiopoietin-like Protein 1/ANGPTL1 Peptides and Angiopoietin-like ...
Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis. Eiji Horio, ... Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis ... Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis ... Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis ...
Response of angiopoietin-like proteins 3 and 4 to hemodialysis.. [Dana Mahmood, Elena Makoveichuk, Solveig Nilsson, Gunilla ... Patients on chronic hemodialysis (cHD) have decreased activity of lipoprotein lipase (LPL). Angiopoietin-like proteins (ANGPTL ...
Angiopoietin-related protein 4 (406 aa, ~45 kDa) is encoded by the human ANGPTL4 gene. This protein plays a role in the ... Angiopoietin-Related Protein 4. Known as: Angiopoietin-Like Protein 4, HFARP, Hepatic Fibrinogen/Angiopoietin-Related Protein ... Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to… ... Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4.. *Hongfei Ge, Guoqing Yang, Lu Huang, ...
Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell ... Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via ...
Angiopoietin-like protein 4, Lipoprotein lipase, Macrophages, GW501516 National Category Biochemistry and Molecular Biology ... Angiopoietin-like protein (ANGPTL) 4 inactivates LPL and ANGPTL4 expression is controlled by peroxisome proliferator-activated ... Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 ...
Recombinant Protein and Angiopoietin-like protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody ... Angiopoietin-like protein 8. Angiopoietin-like protein 8 ELISA Kit. Angiopoietin-like protein 8 Recombinant. Angiopoietin-like ... Also known as Angiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein).. EG624219: Hormone ... Below are the list of possible Angiopoietin-like protein products. If you cannot find the target and/or product is not ...
The role of angiopoietin-like protein 4 (ANGPTL4) in the glomerular endothelial cell injury and progressive glomerular injury. ... We identified the angiopoietin-like protein 4 (ANGPTL4) involved in glomerular endothelial cell (GEC) injury among many induced ...
In this study, we hoped to investigate the changes of Angiopoietin-like protein 3(ANGPTL3) levels in hyperlipidemia patients ... Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria. ... Angiopoietin-like protein 3(ANGPTL3) is well acknowledged as a key regulator of lipid metabolism. Now, there have not been ... Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria. *Xia Gao. ORCID: orcid.org/0000-0001- ...
Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure ... Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure ... Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure ... Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure ...
Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA expression ... fig02: Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA ... fig02: Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA ... Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase- ...
... angiopoietin-related protein 4 (ARP4), PPARγ angiopoietin related gene (PGAR), ANGPTL2, pp1158 and NL2. ... 6. S Mandard, F Zandbergen, E Va Straten, W Wahli, M Muller and S Kersten, The fasting induced adipose factor/angiopoietin-like ... It belongs to the family of fibrinogen/angiopoietinlike proteins and is also referred to as: angiopoietin-like protein 4 ( ... 5. A Xu et al, Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia ...
2009) Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in ... 2007) Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 ... Angiopoietin-like protein 8. Fabiana Quagliarini, Yan Wang, Julia Kozlitina, Nick V. Grishin, Rhonda Hyde, Eric Boerwinkle, ... Angiopoietin-like protein 8. Fabiana Quagliarini, Yan Wang, Julia Kozlitina, Nick V. Grishin, Rhonda Hyde, Eric Boerwinkle, ...
Angiopoietin-1 and angiopoietin-2 can form dimers, trimers, and tetramers. Angiopoietin-1 has the ability to form higher order ... is demonstrated by an increased ratio of angiopoietin-2 and angiopoietin-1 in blood serum. To be specific, angiopoietin levels ... Angiopoietin-1 encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa whereas angiopoietin-2 encodes a 496 ... Angiopoietin-2 is elevated in patients with angiosarcoma. Research has shown angiopoietin signaling to be relevant in treating ...
Angiopoietins are vascular factors essential for blood vessel assembly and correct organization and maturation. This study ... Regulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling Pathways. Irene Pafumi,1 Annarita Favia ... was found to modulate in vitro angiogenic responses to Angiopoietins in a specific way. 2-APB and 8Br-cADPR impaired the ... describes a novel calcium-dependent machinery activated through Angiopoietin-1/2-Tie receptor system in HUVECs monolayer. Both ...
The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind ... The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis). The angiopoietins are ... In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4). Ang1 and ... But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.[citation ...
Angiopoietin-related growth factor (AGF), a member of the angiopoietin-like protein (Angptl) family, is secreted predominantly ... Angiopoietin-related growth factor antagonizes obesity and insulin resistance.. Oike Y1, Akao M, Yasunaga K, Yamauchi T, ...
The angiopoietin/Tie (ANG/Tie) receptor system controls developmental and tumor angiogenesis, inflammatory vascular remodeling ... Fluorescence energy transfer between Tie1 and Tie2 after angiopoietin stimulation of endothelial cells. ...
Buy our Human Angiopoietin 2 peptide. Ab172727 is a blocking peptide for ab125692 and has been validated in BL. Abcam provides ... Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be ...
Buy our Recombinant human Angiopoietin 1 protein. Ab69492 is an active full length protein produced in HeLa cells and has been ... Recombinant human Angiopoietin 1 protein. See all Angiopoietin 1 proteins and peptides. ...
Angiopoietin-1 for Myocardial Angiogenesis , IntechOpen, Published on: 2011-10-21. Authors: Vien Khach Lai, Muhammad Zeeshan ... Angiopoietin-1 for Myocardial Angiogenesis. By Vien Khach Lai, Muhammad Zeeshan Afzal, Muhammad Ashraf and Khawaja Husnain ...
Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of ...
Plasma angiopoietin-1, angiopoietin-2, angiopoietin receptor tie-2, and vascular endothelial growth factor levels in acute ... Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction. Seung-Jun Lee,1 Choong-kun Lee,1,2 ... Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population. Eur J Heart Fail. 2013;15(12): ... Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med. 2006 ...
Compare Angiopoietin-like 7 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, ... Angiopoietin-like 7 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for ... Your search returned 59 Angiopoietin-like 7 ELISA ELISA Kit across 6 suppliers. ...
2012) The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway. Cold Spring Harb Perspect Med 2:a006550. ... 2007) Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2. BMC Cell ... 2011) Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest 121:2278- ... 2006) Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med ...
  • The collective interactions between angiopoietins, receptor tyrosine kinases, vascular endothelial growth factors and their receptors form the two signaling pathways- Tie-1 and Tie-2. (wikipedia.org)
  • citation needed] Angiopoietin#Tie_pathway TIE Receptor Tyrosine Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) Jeltsch M, Leppanen VM, Saharinen P, Alitalo K (2013). (wikipedia.org)
  • The aim of our study was to evaluate the levels of cytokines (osteopontin and angiopoietins 1 and 2) active in the bone marrow niche during the mobilisation of haematopoietic stem cells for autologous transplantation. (sigmaaldrich.com)