Angiopoietins
Angiopoietin-2
An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.
Angiopoietin-1
Receptor, TIE-2
Receptor, TIE-1
Receptors, TIE
Vascular Endothelial Growth Factor A
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Neovascularization, Physiologic
Angiogenesis Inducing Agents
Vascular Endothelial Growth Factors
Neovascularization, Pathologic
Endothelial Growth Factors
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
Receptor Protein-Tyrosine Kinases
Lymphokines
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Blood Vessels
Endothelial Cells
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Endothelium, Vascular
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Vascular Endothelial Growth Factor Receptor-1
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Reverse Transcriptase Polymerase Chain Reaction
Immunohistochemistry
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proto-Oncogene Proteins
Cells, Cultured
Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (1/298)
Using homology-based PCR, we have isolated cDNA encoding a novel member (491 amino acids) of the angiopoietin (Ang) family from human adult heart cDNA and have designated it angiopoietin-3 (Ang3). The NH2-terminal and COOH-terminal portions of Ang-3 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in other known Angs. Ang3 has a highly hydrophobic region at the N-terminus (approximately 21 amino acids) that is typical of a signal sequence for protein secretion. Ang3 mRNA is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine in human adult tissues. Additionally, Ang3 is a secretory protein, but is not a mitogen in endothelial cells. (+info)Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (2/298)
The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist, angiopoietin-2, both of which act by means of the Tie2 receptor. We now report our attempts to use homology-based cloning approaches to identify new members of the angiopoietin family. These efforts have led to the identification of two new angiopoietins, angiopoietin-3 in mouse and angiopoietin-4 in human; we have also identified several more distantly related sequences that do not seem to be true angiopoietins, in that they do not bind to the Tie receptors. Although angiopoietin-3 and angiopoietin-4 are strikingly more structurally diverged from each other than are the mouse and human versions of angiopoietin-1 and angiopoietin-2, they appear to represent the mouse and human counterparts of the same gene locus, as revealed in our chromosomal localization studies of all of the angiopoietins in mouse and human. The structural divergence of angiopoietin-3 and angiopoietin-4 appears to underlie diverging functions of these counterparts. Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist. (+info)Angiopoietin-3, a novel member of the angiopoietin family. (3/298)
A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2. (+info)Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. (4/298)
Using degenerate polymerase chain reaction, we isolated a cDNA encoding a novel 493-amino acid protein from human and mouse adult heart cDNAs and have designated it angiopoietin-related protein-2 (ARP2). The NH(2)-terminal and COOH-terminal portions of ARP2 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in angiopoietins. ARP2 has two consensus glycosylation sites and a highly hydrophobic region at the NH(2) terminus that is typical of a secretory signal sequence. Recombinant ARP2 expressed in COS cells is secreted and glycosylated. In human adult tissues, ARP2 mRNA is most abundant in heart, small intestine, spleen, and stomach. In rat embryos, ARP2 mRNA is most abundant in the blood vessels and skeletal muscles. Endothelial and vascular smooth muscle cells also contain ARP2 mRNA. Recombinant ARP2 protein induces sprouting in vascular endothelial cells but does not bind to the Tie1 or Tie2 receptor. These results suggest that ARP2 may exert a function on endothelial cells through autocrine or paracrine action. (+info)Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (5/298)
Using degenerate PCR we isolated a cDNA encoding a novel 406- and 410-amino acid protein from human and mouse embryonic cDNAs and have designated it 'hepatic fibrinogen/angiopoietin-related protein' (HFARP). The N-terminal and C-terminal portions of HFARP contain the characteristic coiled-coil domains and fibrinogen-like domains that are conserved in angiopoietins. In human and mouse tissues, HFARP mRNA is specifically expressed in the liver. HFARP mRNA and protein are mainly present in the hepatocytes. HFARP has a highly hydrophobic region at the N-terminus that is typical of a secretory signal sequence and one consensus glycosylation site. Recombinant HFARP expressed in COS-7 cells is secreted and glycosylated. HFARP protein is present not only in the hepatocytes, but also in the circulating blood. Recombinant HFARP acts as an apoptosis survival factor for vascular endothelial cells, but does not bind to Tie1 or Tie2 (endothelial-cell tyrosine kinase receptors). These results suggest that HFARP may exert a protective function on endothelial cells through an endocrine action. (+info)Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. (6/298)
The angiopoietins are recently described growth factors for vascular endothelium. The Tie1 and Tie2 receptors are expressed by endothelium. Acquired immune deficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS) and cutaneous angiosarcoma are malignancies of endothelial origin. KS involves primarily the skin and mucosal surfaces and is common in AIDS patients. In an effort to determine whether the angiopoietins and Tie receptors play a role in the pathobiology of angiosarcoma and KS, we studied the expression of angiopoietin-1, angiopoietin-2, angiopoietin-4, Tie1, and Tie2 mRNAs in biopsies of KS from 12 AIDS patients, in biopsies of cutaneous angiosarcoma from two patients, and in control biopsies of normal skin from three volunteers by in situ hybridization. Strong expression of angiopoietin-2, Tie1, and Tie2 mRNAs was detected in the tumor cells of KS and cutaneous angiosarcomas, in contrast to the focal low-level expression in normal skin biopsies. Focal low-level expression of angiopoietin-1 was seen in KS, cutaneous angiosarcomas, and in normal skin. Focal low-level expression of angiopoietin-4 was identified in a minority of KS lesions. These findings suggest that the angiopoietins and Tie receptors may play an important role in the pathobiology of KS and cutaneous angiosarcoma and identify additional potential targets for therapeutic intervention in these vascular malignancies. (+info)Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. (7/298)
Fasting is associated with significant changes in nutrient metabolism, many of which are governed by transcription factors that regulate the expression of rate-limiting enzymes. One factor that plays an important role in the metabolic response to fasting is the peroxisome proliferator-activated receptor alpha (PPARalpha). To gain more insight into the role of PPARalpha during fasting, and into the regulation of metabolism during fasting in general, a search for unknown PPARalpha target genes was performed. Using subtractive hybridization (SABRE) comparing liver mRNA from wild-type and PPARalpha null mice, we isolated a novel PPARalpha target gene, encoding the secreted protein FIAF (for fasting induced adipose factor), that belongs to the family of fibrinogen/angiopoietin-like proteins. FIAF is predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. Moreover, FIAF mRNA is decreased in white adipose tissue of PPARgamma +/- mice. FIAF protein can be detected in various tissues and in blood plasma, suggesting that FIAF has an endocrine function. Its plasma abundance is increased by fasting and decreased by chronic high fat feeding. The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions. (+info)Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (8/298)
The nuclear receptor peroxisome proliferator-activated receptor gamma regulates adipose differentiation and systemic insulin signaling via ligand-dependent transcriptional activation of target genes. However, the identities of the biologically relevant target genes are largely unknown. Here we describe the isolation and characterization of a novel target gene induced by PPARgamma ligands, termed PGAR (for PPARgamma angiopoietin related), which encodes a novel member of the angiopoietin family of secreted proteins. The transcriptional induction of PGAR follows a rapid time course typical of immediate-early genes and occurs in the absence of protein synthesis. The expression of PGAR is predominantly localized to adipose tissues and placenta and is consistently elevated in genetic models of obesity. Hormone-dependent adipocyte differentiation coincides with a dramatic early induction of the PGAR transcript. Alterations in nutrition and leptin administration are found to modulate the PGAR expression in vivo. Taken together, these data suggest a possible role for PGAR in the regulation of systemic lipid metabolism or glucose homeostasis. (+info)
Angiopoietin-like Protein 1/ANGPTL1 Proteins: Novus Biologicals
Recombinant Human Angiopoietin-like Protein 6 [PRP-832CYT]
Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria | Lipids in Health and Disease | Full...
Angiopoietin-like protein elisa and antibody
Angiopoietin-related protein 2 - Wikipedia
Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4...
Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: A brown adipose tissue-derived endocrine factor with a potential role in...
Angiopoietin-like protein 2 (ANGPTL2) induces expressio | Open-i
Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via...
Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell...
Angiopoietin-Related Protein 4 | Semantic Scholar
Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis | Circulation
Angiopoietin-like Protein 5/ANGPTL5 Antibody (H00253935-D01P): Novus Biologicals
KAKEN - Research Projects | The role of angiopoietin-like protein 4 (ANGPTL4) in the glomerular endothelial cell injury and...
Angiopoietin-Like Protein 4 - from Sheep - for ELISA - Antigene from HEK293 - Antibodies | BioVendor Research and Diagnostics...
Angiopoietin-Like Protein 4 - Polyclonal Antibody - from Rabbit - Antigene from E. coli - Antibodies | BioVendor Research and...
Response of angiopoietin-like proteins 3 and 4 to hemodialysis. | Sigma-Aldrich
The direct peroxisome proliferator-activated receptor target fasting-induced adi :: TNO Repository
Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise<...
A Polyglucuronic Acid to Target the FIAF Adipokine for Slimming Effects
The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy...
Angiopoietin-related growth factor antagonizes obesity and insulin resistance. - PubMed - NCBI
Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its...
Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity
TNO Repository search for: creator:Tan, N.S.
Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage ...
ANGPTL4 Human Recombinant Protein - Cytokines - Recombinant Protein - Full-Length Protein - Products | ProMab
Model of tumor cell resistance to antineoplastic therap | Open-i
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The gut microbiota as an environmental factor that regulates fat storage | PNAS
Search Results | Clinical Science | Portland Press
Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease
JCI -
Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema
lipid migration
Applications filed at Dec 14 2017 | ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF | Patents.com
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic...
OriGene - ANGPTL4 (NM 001039667) Human ORF cDNA Clone
OriGene - Angptl4 (NM 199115) Human ORF cDNA Clone
Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin...
Most recent papers with the keyword Fatty Acid Metabolism Suberate | Read by QxMD
ANGPTL3 purified MaxPab rabbit polyclonal antibody (D01P) - (H00027329-D01P) - Products - Abnova
Second blood-vessel-growth protein implicated in PDR | OphthalmologyTimes
Germain - CIRB - Collège de France
ANGPTL3 (Human) Recombinant Protein (Q01) - (H00027329-Q01) - Products - Abnova
Pro-inflammatory and angiogenic activities of VEGF and angiopoietins in murine sponge/Matrigel model
Biology Animations: Role for Angiopoietins Animation
Gentaur Molecular :Prospecbio \ Mouse Anti Human Angiopoietin Like Protein 3 ANGPTL3 \ ant-310
Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density...
DGIST Scholar: Effect of bexarotene on differentiation of glioblastoma multiforme compared with ATRA
ANGPTL3 (human) LANCE Ultra TR-FRET Detection Kit, 500 Assay Points | PerkinElmer
ANGPTL3 (human) LANCE Ultra TR-FRET Detection Kit, 10,000 Assay Points | PerkinElmer
Expression of ANGPTL2 in cancer - Summary - The Human Protein Atlas
ANGPTL7 Mouse | ProSpec
Angiopoietin Like Protein 8 (ANGPTL8) Polyclonal Antibody, Cat#CAU21004 - Biomatik
AGF Names Vice-President of Global Consultant Relations
FIAF - International Federation of Film Archives
FIAF - International Federation of Film Archives
Human Gene ANGPTL7 (ENST00000376819.4) Description and Page Index
Recebimento de Mensagem com Virus
Angiopoietin
... -1 and angiopoietin-2 can form dimers, trimers, and tetramers. Angiopoietin-1 has the ability to form higher order ... is demonstrated by an increased ratio of angiopoietin-2 and angiopoietin-1 in blood serum. To be specific, angiopoietin levels ... Angiopoietin-1 encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa whereas angiopoietin-2 encodes a 496 ... Angiopoietin-2 has been proposed as a biomarker in different cancer types. Angiopoietin-2 expression levels are proportional to ...
Angiopoietin receptor
The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind ... The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis). The angiopoietins are ... In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4). Ang1 and ... But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.[citation ...
Angiopoietin 1
... is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in ... increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta. This suggests that ... Dunk C, Shams M, Nijjar S (2000). "Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration ... Cheung AH, Stewart RJ, Marsden PA (1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): ...
Angiopoietin-like proteins
The Angiopoietin-like proteins are proteins structurally like the angiopoietins but which do not bind to the angiopoietin ... Angiopoietin-related protein 1, gene ANGPTL1 Angiopoietin-related protein 2, gene ANGPTL2 Angiopoietin-related protein 3, gene ... Angiopoietin-related protein 7, gene ANGPTL7 Angiopoietin-related protein 8, gene ANGPTL8, also known as lipasin because of its ... gene ANGPTL4 Angiopoietin-related protein 5, gene ANGPTL5, mainly expressed in adult human heart. Angiopoietin-related protein ...
Angiopoietin-related protein 1
Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this ... Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein ...
Angiopoietin-related protein 7
... is a protein that in humans is encoded by the ANGPTL7 gene. It is one of the 8 angiopoietin-like ... "Entrez Gene: ANGPTL7 angiopoietin-like 7". Angiopoietin-like proteins: a comprehensive look Tanigawa, Yosuke; Wainberg, Michael ... Peek R, Kammerer RA, Frank S, Otte-Holler I, Westphal JR (Jan 2002). "The angiopoietin-like factor cornea-derived transcript 6 ...
Angiopoietin-related protein 2
Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted ... Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 ... and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J Biol ... Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific ...
Hes3 signaling axis
Activation of the Tie2 receptor by the ligand Angiopoietin 2. This has been shown in vitro and in vivo. Activation of the ... Activation of the signaling pathway by Delta4, Angiopoietin 2, insulin, or a combination of the three and a JAK inhibitor ... Angiopoietin 2). Hes3, in turn, by regulating the expression of Shh and potentially other factors, can also exert an effect on ... Angiopoietin 2, insulin, or a combined treatment consisting of all three factors and an inhibitor of JAK) induce the increase ...
ANGPT4
Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene. Angiopoietins are proteins with important roles in ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3-4): 147-54. ... "Entrez Gene: ANGPT4 angiopoietin 4". Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser. ...
ANGPTL3
Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene. The protein encoded by ... "Entrez Gene: ANGPTL3 angiopoietin-like 3". Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, et al. (December ... The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced ... Kaplan R, Zhang T, Hernandez M, Gan FX, Wright SD, Waters MG, Cai TQ (January 2003). "Regulation of the angiopoietin-like ...
Nesvacumab
It targets the protein angiopoietin 2. As of May 2017[update], it is in Phase II clinical trials for the treatment of diabetic ... "Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of ...
Gelareh Zadeh
Her doctoral research looked at the role of angiopoietins in astrocytoma angiogenesis. After earning her doctorate Zadeh moved ... Zadeh, Gelareh (2007). Role of angiopoietins and Tie2/TEK in astrocytoma angiogenesis (Thesis). OCLC 234132296. "Dr. Gelareh ...
ANGPTL8
Three dimensional structure of none of the members of Angiopoietin like proteins (ANGPTLs) is available up until now.[when?] ... "Atypical angiopoietin-like protein that regulates ANGPTL3". Proceedings of the National Academy of Sciences of the United ... is a novel but atypical member of the angiopoietin-like protein family". Biochemical and Biophysical Research Communications. ... "Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways". Genomics. ...
TEK tyrosine kinase
January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig- ... angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization". Circulation Research. 83 (3): 233-40. ... Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the ... Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (November 2001). "Dok-R plays a pivotal role in angiopoietin-1- ...
ANGPT2
Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 ... Xu Y, Yu Q (September 2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its ... Cheung AH, Stewart RJ, Marsden PA (March 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 ( ... "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ...
Angiogenesis
The angiopoietins, Ang1 and Ang2, are required for the formation of mature blood vessels, as demonstrated by mouse knock out ... Thurston G (October 2003). "Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis". ...
Evinacumab
... binds to the angiopoietin-like protein 3 (ANGPTL3). ANGPTL3 slows the function of certain enzymes that break down ...
Epithelial-mesenchymal transition
Li JJ, Huang YQ, Basch R, Karpatkin S (February 2001). "Thrombin induces the release of angiopoietin-1 from platelets". ... Angiopoietin-1) and cytokines including the EMT inducer TGF-β. The release of TGF-β by platelets in blood vessels near primary ...
ANGPTL4
July 2007). "Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin ... Angiopoietin-like 4 is a protein that in human is encoded by the ANGPTL4 gene. Alternatively spliced transcript variants ... July 2017). "Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen ... June 2015). "Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative ...
Pericyte
Angiopoietin 2 can act as an antagonist to Tie-2, destabilizing the endothelial cells, which results in less endothelial cell ... Angiopoietin 1 and Tie-2 signaling is essential for maturation and stabilization of endothelial cells. Platelet-derived growth ... Similar to the inhibition of the PDGF pathway, angiopoietin 2 reduces levels of pericytes, leading to diabetic retinopathy. ... "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...
N-Acetylmannosamine
Chugh, S; Macé, C; Clement, L; Del Nogal, A; Marshall, C (2014). "Angiopoietin-like 4 based therapeutics for proteinuria and ...
Koh Gou Young
"Attenuated angiopoietin-Tie2 signaling regresses Schlemm's canal integrity and induces glaucoma". Journal of Clinical ...
Thomas N. Sato
... and angiopoietins, that play the key roles in the blood vessel formation. National Science Contest for Elementary School ... "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis". Cell. 87 (7): 1171-1180. doi: ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...
FCN3
Zeng L, Dai J, Ying K (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet ...
GRLF1
Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). "Angiopoietin-1 ...
Michele De Palma
He later showed that inhibition of the Tie2-ligand Angiopoietin 2 induces tumor regression and inhibits metastasis by ... He also identified expression of Angiopoietin 2 as an adaptive resistance mechanism upon anti-angiogenic treatment by VEGF ... "Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade". Cell Reports. 8 (3): 696-706. doi:10.1016/j. ... "Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade". Science ...
Host response to cancer therapy
Regulation by Hypoxia and Angiopoietin-2". Cancer Research. 67 (18): 8429-8432. doi:10.1158/0008-5472.CAN-07-1684. ISSN 0008- ...
Subdural hematoma
Mediators that promote angiogenesis are angiopoietin and vascular endothelial growth factor (VEGF). Prostaglandin E2 promotes ...
Vascular endothelial growth factor
Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in ... The expression of angiopoietin-2 in the absence of VEGF leads to endothelial cell death and vascular regression. Conversely, a ...
FCN1
2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159-62. doi: ...
Frontiers | ETS1, ELK1, and ETV4 Transcription Factors Regulate Angiopoietin-1 Signaling and the Angiogenic Response in...
Background: Angiopoietin-1 (Ang-1) is the main ligand of Tie-2 receptors. It promotes endothelial cell (EC) survival, migration ... Background: Angiopoietin-1 (Ang-1) is the main ligand of Tie-2 receptors. It promotes endothelial cell (EC) survival, migration ... 2016). Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts. J. ... Kim, I., Kim, H. G., So, J. N., Kim, J. H., Kwak, H. J., and Koh, Y. (2000). Angiopoietin-1 regulates endothelial cell survival ...
Rat Angiopoietin 4 ELISA kit, AMS.E02A0637 | AMSBIO
Medical Science Monitor | Ratio of Angiopoietin-2 to Angiopoietin-1 predicts mortality in acute lung injury induced by paraquat...
... angiopoietin-2 (Ang-2), and von Willebrand factor (VWF) reflecting endothelial cell injury, we investigated the initial ... induced endothelial cell injury is involved in early death after paraquat intoxication and concentrations of angiopoietin-1 ( ... Ratio of Angiopoietin-2 to Angiopoietin-1 predicts mortality in acute lung injury induced by paraquat Jae-Sung ChoiAEF, Kyung-A ... Keywords: Paraquat - poisoning, Angiopoietin-2 - blood, Angiopoietin-1 - blood, Acute Lung Injury - mortality, Survival ...
Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese ...
Keywords: Angiopoietin-2, colorectal cancer, polymorphism Citation styles. APA Copy. Du, Z., Tang, C.H., Li, L.J., Kang, L., ... Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese. Int J ... Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese. Int J ... Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese. Int J ...
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Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis | BMC Cancer |...
Human - Angiopoietin-Like Protein 4 - from Sheep - Antibodies | BioVendor Research and Diagnostics Products
Human - Angiopoietin-Like Protein 4 - from Sheep - Antibodies. Product filter Angiopoietin-Like Protein 4 molecule Acylation- ... Angiopoietin-Like Protein 3 Angiopoietin-Like Protein 4 Angiostatin Annexin A1 Apolipoprotein D Apolipoprotein M Apoptosis ... Angiopoietin-Like Protein 4 (HEK) Human, Sheep Polyclonal Antibody Type: Polyclonal Antibody. ...
"Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 durin" by Amy S Erickson Hagen, Ryan J Orbus et al.
Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are angiogenic growth factors expressed in the placenta, and compete for ... Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are angiogenic growth factors expressed in the placenta, and compete for ... Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 during placental development in an ovine model of placental ...
A 7-day high-PUFA diet reduces angiopoietin-like protein 3 and 8 responses and postprandial triglyceride levels in healthy...
Angiopoietins and angiopoietin-like proteins in angiogenesis<...
Angiopoietins and angiopoietin-like proteins in angiogenesis. Tohru Morisada, Yoshiaki Kubota, Takashi Urano, Toshio Suda, ... Angiopoietins and angiopoietin-like proteins in angiogenesis. / Morisada, Tohru; Kubota, Yoshiaki; Urano, Takashi et al. ... Morisada T, Kubota Y, Urano T, Suda T, Oike Y. Angiopoietins and angiopoietin-like proteins in angiogenesis. Endothelium: ... Angiopoietins and angiopoietin-like proteins in angiogenesis. In: Endothelium: Journal of Endothelial Cell Research. 2006 ; Vol ...
Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD - Northumbria Research Link
Angiopoietin-1 (Ang-1), is an essential mediator of angiogenesis by establishing vascular integrity, whereas angiopoietin-2 ( ... Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD ... We determined the levels of angiopoietins in sputum supernatants of patients with COPD and investigated their possible ... Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD. Cytokine, 58 (3). pp. 455-460. ISSN 1043- ...
Bovine Angiopoietin 1 (ANGPT1) ELISA Kit, Cat#EKU02356 - Biomatik
Bovine Angiopoietin 1 (ANGPT1) ELISA Kit, Cat#EKU02356. Write a Review Write a Review. × ... Bovine Angiopoietin 1 (ANGPT1) ELISA Kit, Cat#EKU02356. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars ( ... This assay has high sensitivity and excellent specificity for detection of Angiopoietin 1 (ANGPT1). No significant cross- ... reactivity or interference between Angiopoietin 1 (ANGPT1) and analogues was observed.. Test principle. This assay employs the ...
Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: Possible in vivo regulation via induction of proteases<...
Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma : Possible in vivo regulation via induction of proteases. ... Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma : Possible in vivo regulation via induction of proteases. ... T1 - Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma. T2 - Possible in vivo regulation via induction of ... Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: Possible in vivo regulation via induction of proteases」の研 ...
Angiopoietin-2 Promotes Pathological Angiogenesis And Is A Novel Therapeutic Target In Murine Non-alcoholic Fatty Liver Disease...
This original study demonstrates that serum angiopoietin-2 levels are increased in patients with NASH and correlate with liver ... The main source of hepatic angiopoietin-2 was liver sinusoidal endothelial cells (LSECs). Inhibiting angiopoietin-2 levels ... Angiopoietin-2 promotes pathological angiogenesis and is a novel therapeutic target in murine non-alcoholic fatty liver disease ... This original study demonstrates that serum angiopoietin-2 levels are increased in patients with NASH and correlate with liver ...
Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis...
Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis ... Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis ... In mature vessels, angiopoietins control vascular permeability, inflammation and remodeling. A crucial role of angiopoietins is ... In mature vessels, angiopoietins control vascular permeability, inflammation and remodeling. A crucial role of angiopoietins is ...
Angiopoietin-tie2 - Mannin Research Inc.
Host angiopoietin-2 inhibits tumor growth and angiogenesis in the liver - Department of Oncology
Angiopoietin 2 Antibody | R32640 NSJ Bioreagents
This highly specific Angiopoietin 2 antibody is suitable for use in WB, IHC-P and ELISA and is guaranteed to work as stated on ... This Angiopoietin 2 antibody is available for research use only. Review this product on BioCompare and get a $20 Amazon gift ... After reconstitution, the Angiopoietin 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at ... ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1 ...
Bovine Angiopoietin 1 (ANGPT1) ELISA Kit - Bioss
Kounis Syndrome
Rat ANG1 (Angiopoietin 1) ELISA Kit - BidScientific.com
Human Angiopoietin-related protein 1(ANGPTL1) ELISA kit | Doron Scientific
MMRRC:041996-MU
Choroidal Neovascularization (CNV) Medication: Anti-VEGF therapy, Photosensitizers for photodynamic therapy, Ophthalmics, VEGF...
IMSEAR at SEARO: Angiopoietin like protein 3 (Angptl3), fatty acid binding protein 4 (FABP4) and homeostasis model assessment...
Heier Talks Anti-Angiopoietin Programs, Clinical Trials & Red Sox | Ophthalmology Innovation Source
The angiopoietin Tie2 pathway is much more complex, or at least to us at this stage in our understanding, its much more ... Heier Talks Anti-Angiopoietin Programs, Clinical Trials & Red Sox March 2, 2016 ... gives an update from the Angiogenesis conference about the advancing anti-angiopoietin programs. ...
Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration<...
Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration. Chungho Kim, Hyo Seon ... Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration. / Kim, Chungho; Lee, Hyo ... Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration. Blood. 2011 Jan 27;117(4 ... Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration. In: Blood. 2011 ; Vol. ...
Science Clips - Volume 15, Issue 4, January 24, 2023
Reflecting endothelialANGPTL3ProteinAngiogenesisTie2ANG1ReceptorAngiogenicAng2Endothelial CellsANGPT1PlacentalAntibodyInflammationLigandInhibitorsGeneRegulatorsSerumProteinsMutationsInflammatoryTIE2ProteinsVEGFLigandsANGPT2ELISAANG2Endothelial cellAntagonistExpressionGeneInhibitsSolubleSpecificityApoptosisPeptibodyPlasmaTie1Protein calledReceptorsBlood vessel
Reflecting endothelial1
- Background: To determine whether initial reactive oxygen species (ROS)-induced endothelial cell injury is involved in early death after paraquat intoxication and concentrations of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and von Willebrand factor (VWF) reflecting endothelial cell injury, we investigated the initial endothelial cell injury marker involved in the pathogenesis of death within 5 days after paraquat ingestion. (medscimonit.com)
ANGPTL34
- IMSEAR at SEARO: Angiopoietin like protein 3 (Angptl3), fatty acid binding protein 4 (FABP4) and homeostasis model assessment of insulin resistance (HOMA-IR) among Indonesian obese non diabetic males. (who.int)
- AIMS : Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. (ox.ac.uk)
- This medicine is an ANGPTL3 (angiopoietin-like protein 3) inhibitor. (mayoclinic.org)
- Evinacumab is a recombinant human monoclonal antibody that binds to and inhibits angiopoietin-like 3 (ANGPTL3). (medscape.com)
Protein5
- ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. (nsjbio.com)
- Amino acids E180-D283 from the human protein were used as the immunogen for the Angiopoietin 2 antibody. (nsjbio.com)
- Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis. (ox.ac.uk)
- Excessive angiopoietin-like protein (ANGPTL)-2 signaling causes chronic tissue inflammation, promoting development and progression of aging-related diseases. (fujita-hu.ac.jp)
- Angiopoietin-like protein 6 in patients with obesity, type 2 diabetes mellitus, and anorexia nervosa: The influence of very low-calorie diet, bariatric surgery, and partial realimentation. (medscape.com)
Angiogenesis9
- The TEK receptor tyrosine kinase (Tie-2) and its ligand angiopoietin-1 (ANPGT1, Ang-1) have emerged as important regulators of angiogenesis, both in adults and in embryos. (frontiersin.org)
- Interestingly, Angptls also function in angiogenesis through regulating survival and migration of endothelial cells, although Angptls do not bind the angiopoietin receptor Tie2. (elsevier.com)
- Here, the authors review current findings relating to the roles of angiopoietins and Angptls in vascular biology and discuss molecular mechanisms relevant to these factors and angiogenesis. (elsevier.com)
- Angiopoietin-1 (Ang-1), is an essential mediator of angiogenesis by establishing vascular integrity, whereas angiopoietin-2 (Ang-2) acts as its natural inhibitor. (northumbria.ac.uk)
- Angiopoietin-2 Promotes Pathological Angiogenesis And Is A Novel Therapeutic Target In Murine Non-alcoholic Fatty Liver Disease. (pannash.org)
- Inhibiting angiopoietin-2 levels using the angiopoietin-2/Tie2 receptor inhibiting peptibody L1-10 reduced hepatic angiogenesis and normalized vascular microarchitecture. (pannash.org)
- These findings provide evidence for angiopoietin -2 inhibition as a therapeutic strategy to target pathological angiogenesis in NASH. (pannash.org)
- Jeff Heier, MD , is the Director of the Vitreoretinal Service and the Director of Retina Research at Ophthalmic Consultants of Boston (OCB) gives an update from the Angiogenesis conference about the advancing anti-angiopoietin programs. (ois.net)
- As a member of the angiopoietin family, Angiopoietin-2 (Ang-2) plays an irreplaceable role in angiogenesis. (nih.gov)
Tie26
- Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling. (elsevier.com)
- It has been reported that the angiopoietin/Tie2 signal is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. (elsevier.com)
- More recent studies demonstrate that angiopoietin/Tie2 signaling is also required for lymphangiogenesis. (elsevier.com)
- The data suggests that the Angiopoietin-Tie2 signaling pathway is a promising therapeutic target to prevent. (mannin.ca)
- The angiopoietin Tie2 pathway is much more complex, or at least to us at this stage in our understanding, it's much more complex. (ois.net)
- The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation. (bvsalud.org)
ANG13
- The angiogenic growth factors, Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2), are crucial regulators of vessel formation and maintenance starting with embryonic development and continuing through life. (uniroma1.it)
- In this review, we present a summary of the role of Ang1 and Ang2, their involvement in diabetic complications, and novel therapeutic strategies targeting angiopoietins to ameliorate vascular health in metabolic disorders. (uniroma1.it)
- Angiopoietin-1 (Ang1) has been defined as a ligand from the endothelial selective receptor tyrosine kinase (RTK), Link2. (conferencedequebec.org)
Receptor1
- Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are angiogenic growth factors expressed in the placenta, and compete for binding to a common receptor, Tunica interna endothelial cell kinase-2 (Tie-2). (uwo.ca)
Angiogenic1
- Real-time polymerase chain reaction demonstrated significant upregulation of angiopoietin-2 (Ang-2) in ischemic myocardium, to a greater extent than other classical angiogenic factors. (univ-angers.fr)
Ang21
- Angiopoietin-2 (Ang2), an endothelial tyrosine kinase, is involved in CRC progression, but little is known about the association between single nucleotide polymorphisms (SNPs) and diagnosis or prognosis of CRC. (medsci.org)
Endothelial Cells1
- The main source of hepatic angiopoietin-2 was liver sinusoidal endothelial cells (LSECs). (pannash.org)
ANGPT12
- This assay has high sensitivity and excellent specificity for detection of Angiopoietin 1 (ANGPT1). (biomatik.com)
- No significant cross-reactivity or interference between Angiopoietin 1 (ANGPT1) and analogues was observed. (biomatik.com)
Placental3
- Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 durin" by Amy S Erickson Hagen, Ryan J Orbus et al. (uwo.ca)
- Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 during placental development in an ovine model of placental insufficiency-fetal growth restriction. (uwo.ca)
- IHC testing of FFPE human placental tissue with Angiopoietin 2 antibody at 1ug/ml. (nsjbio.com)
Antibody6
- Western blot testing of human HepG2 cell lysate with Angiopoietin 2 antibody. (nsjbio.com)
- This Angiopoietin 2 antibody is available for research use only. (nsjbio.com)
- Optimal dilution of the Angiopoietin 2 antibody should be determined by the researcher. (nsjbio.com)
- After reconstitution, the Angiopoietin 2 antibody can be stored for up to one month at 4oC. (nsjbio.com)
- Western blot analysis of extracts from various cell lines using Angiopoietin-2 (D200) Antibody (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). (cellsignal.com)
- The absence of angiopoietin-2 expression in A-431 cell extracts is consistent with molecular and proteomic expression profiling data, confirming specificity of the antibody. (cellsignal.com)
Inflammation4
- This original study demonstrates that serum angiopoietin-2 levels are increased in patients with NASH and correlate with liver steatosis, inflammation and hepatocyte ballooning, but not with liver fibrosis. (pannash.org)
- In mature vessels, angiopoietins control vascular permeability, inflammation and remodeling. (uniroma1.it)
- A crucial role of angiopoietins is to drive vascular inflammation from the active to the quiescent state, enabling restoration of tissue homeostasis. (uniroma1.it)
- Association between inflammation, angiopoietins, and disease severity in critically ill COVID-19 patients: a prospective study. (amedeo.com)
Ligand1
- Angiopoietin-1 (Ang-1) is the main ligand of Tie-2 receptors. (frontiersin.org)
Inhibitors1
- Other agents (eg, leukotriene inhibitors, N -acetylcysteine, angiopoietin-1) have shown benefit in animal studies. (medscape.com)
Gene1
- Du Z, Tang CH, Li LJ, Kang L, Zhao J, Jin L, Wang CQ, Su CM. Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese. (medsci.org)
Regulators1
- Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. (medlineplus.gov)
Serum3
- Serum was stored for measurement of levels of Angiopoietin (Ang)-1, Ang-2, soluble (s)P-selectin, sE-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and platelet and endothelial cell adhesion molecule-1. (rug.nl)
- No significant differences in serum levels of the Angiopoietins or soluble cellular adhesion molecules between groups were observed at start of antibiotic treatment nor after 48-72 h. (rug.nl)
- Serum was stored for measurement of levels of Angiopoietin (Ang)-1, Ang-2, soluble (s)P-selectin, sE-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and platelet and endothelial cell adhesion molecule-1.Results: Fifty-one children were included of whom 10 had a positive blood culture. (rug.nl)
Proteins1
- The authors and several other groups have identified six angiopoietin-like proteins (Angptls) containing a coiled-coil domain and a fibrinogen-like domain, both of which are characteristic of angiopoietins. (elsevier.com)
Mutations1
- Mechanisms include mutations of the genes encoding coagulation factor XII, angiopoietin-1, plasminogen and as yet undefined factors. (cdc.gov)
Inflammatory1
- We determined the levels of angiopoietins in sputum supernatants of patients with COPD and investigated their possible association with mediators and cells involved in the inflammatory and remodeling process. (northumbria.ac.uk)
TIE216
- During angiogenesis, ANG2 exerts its effects via the angiopoietin-1/TIE2 receptor signaling system on endothelial cells. (tecomedical.com)
- Interestingly, the hemodynamic alterations associated with endothelial-specific overexpression of ANG2 and the loss of capillary-associated pericytes were reversed by intravenous injections of adeno-associated viruses (AAVs) transducing cDNA for angiopoietin 1, a TIE2 ligand that antagonizes ANG2, or AAVs encoding PDGFB, a chemoattractant for pericytes. (mpg.de)
- Since Angiopoetin-1 signaling through the Tie2 receptor on endothelial cells opposes microvascular perturbations in other disease contexts, we used a preclinical Angiopoietin-1 mimic called Vasculotide to investigate its effect on skin radiation toxicity using a preclinical model. (biomedcentral.com)
- Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth. (ox.ac.uk)
- Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling. (elsevier.com)
- It has been reported that the angiopoietin/Tie2 signal is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. (elsevier.com)
- More recent studies demonstrate that angiopoietin/Tie2 signaling is also required for lymphangiogenesis. (elsevier.com)
- Interestingly, Angptls also function in angiogenesis through regulating survival and migration of endothelial cells, although Angptls do not bind the angiopoietin receptor Tie2. (elsevier.com)
- Angiopoietins are ligands of the endothelial cell tyrosine kinase receptor Tie2. (crcm-marseille.fr)
- Angiopoietin-1 (Ang-1) is widely expressed in human normal adult tissues and promotes blood vessel maturation and stabilization by inducing Tie2 receptor phosphorylation. (crcm-marseille.fr)
- Second, we are exploring new mechanisms and treatments for hepatorenal syndrome by examining regulators of vascular inflammation and endothelial cell dysfunction (such as Angiopoietin/Tie2 signaling). (massgeneral.org)
- [1] [2] Also known as TIE2 , it is an angiopoietin receptor . (wikidoc.org)
- Trebananib is designed to bind to both angiopoietin-1 and -2 (Ang1 and Ang2), and inhibit their interaction with the Tie2 receptor. (takeda.com)
- The molecular function of TIE1 is not completely understood, as it does not directly bind the angiopoietin growth factors, which are the ligands for TEK (TIE2). (atlasgeneticsoncology.org)
- Tie2, on the other hand, has been studied extensively and has four known binding ligands, angiopoietin (Ang) 1-4 (reviewed in ref. 2 ). (aacrjournals.org)
- Recent reports have identified a key role of the angiopoietin-Tie2 pathway. (renalresearch.com)
Proteins7
- Circulating angiopoietin-like proteins in metabolic-associated fatty liver disease: a systematic review and meta-analysis. (nih.gov)
- The authors and several other groups have identified six angiopoietin-like proteins (Angptls) containing a coiled-coil domain and a fibrinogen-like domain, both of which are characteristic of angiopoietins. (elsevier.com)
- Angiopoietins are proteins with important roles in vascular development and angiogenesis. (elisa-kits.de)
- Two domains characterize the angiopoietin family of proteins: an N-terminal coiled-coil domain that mediates homo-oligomerization, and a C-terminal fibrinogen-like domain that binds Tie-2 The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. (elisa-kits.de)
- The family of angiopoietin-like (ANGPTL) proteins consists of 8 members (ANGPTL1-8) that have disparate effects on physiology. (elsevier.com)
- Most importantly, inhibiting both VEGF and angiopoietin-like 4 reduced angiogenesis more than targeting just one of the proteins. (nih.gov)
- Angiopoietin-like proteins (ANGPTLs), which comprise 7 members (ANGPTL1-ANGPTL7), structurally resemble angiopoietins. (deepdyve.com)
VEGF12
- To determine the temporal expression of vascular growth factors during the lifespan of the primate corpus luteum, experiments were designed to detect mRNA for vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1 and Ang-2 and to localize protein expression for VEGF in macaque luteal tissue during the menstrual cycle. (oregonstate.edu)
- Dual inhibition of angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF)-A with faricimab, the first bispecific antibody designed for intraocular use, may synergistically promote vascular stability and reduce treatment burden through extended durability in patients with neovascular age-related macular degeneration (nAMD). (arvojournals.org)
- By restricting oxygen flow to retinal cells, the team went on to discover a protein called angiopoietin-like 4 that, like VEGF, is present at much higher levels in the oxygen-deprived cells. (nih.gov)
- These results suggest that a drug that could block the action of angiopoietin-like 4 might help prevent proliferative diabetic retinopathy, particularly if combined with VEGF. (nih.gov)
- Further experiments on the lab-grown human cells revealed that blocking the action of both VEGF and angiopoietin-like 4 markedly reduced blood vessel growth. (nih.gov)
- Also, it may be useful to measure the levels of angiopoietin-like 4 protein before deciding to treat proliferative diabetic retinopathy with anti-VEGF therapy. (nih.gov)
- b The MSCs commonly generate and release varied angiogenic mediators surrounding angiopoietin-1 (ANG-1) and IL-6 that, in turn, provoke the release of VEGF and other angiogenic factors stimulating tumor angiogenesis. (biomedcentral.com)
- MedImmune, LLC and Abpro, collaborated in December 2016 to develop novel bispecific antibody, Ang2-VEGF, which targets angiopoietin-2 and vascular endothelial growth factor. (openpr.com)
- Two circulating permeability factors, VEGF and Angiopoietin 2 (Ang2), were significantly elevated in episodic SCLS sera. (nih.gov)
- Our results support a model of SCLS pathogenesis in which canonical permeability mediators such as VEGF and Angiopoietin 2, but not immunoglobulins, transiently activate pathogenic endothelial contraction pathways, suggesting a molecular mechanism and novel potential targets for this highly lethal disorder. (nih.gov)
- We also have some other exciting things such as OPT-302, which inhibits not only VEGF-A but VEGF-C and -D. That could be a nice compliment to something like faricimab, which inhibits angiopoietin-2, and we will see if other types of VEGF isoform inhibition may allow us to have better outcomes in some of our patients as well. (consultantlive.com)
- Faricimab also blocks VEGF, but in addition it blocks angiopoietin-2 (Ang-2). (medscape.com)
Ligands2
- Interesting, studies have shown that, the glioma endothelium expresses high levels of Tie 2 and its ligands, angiopoietins-1 and -2 (Ang-1, -2). (aacrjournals.org)
- Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. (medlineplus.gov)
ANGPT23
- Description: A sandwich quantitative ELISA assay kit for detection of Human Angiopoietin 2 (ANGPT2) in samples from serum, plasma or other biological fluids. (bioemm.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Angiopoietin 2 (ANGPT2) in serum, plasma, tissue homogenates and other biological fluids. (bioemm.com)
- SCF, IL-3, thrombopoietin (Thpo) and angiopoietin-2 (Angpt2) were evaluated with semi-quantitative real-time RT-PCR using mRNA isolated from c-Kit? (bioinf.org)
ELISA4
- Your search returned 422 Angiopoietin 1 ELISA ELISA Kit across 24 suppliers. (biocompare.com)
- Description: Quantitativesandwich ELISA kit for measuring Human angiopoietin-like protein 2 (ANGPTL2) in samples from serum, plasma, cell culture supernates, tissue homogenates. (signetlabs.com)
- The BioAim Human Angiopoietin-1 EasyTest™ ELISA kit can quantitatively measure human Angiopoietin-1 in serum and plasma. (elisa-kits.de)
- Bovine TEK/Angiopoietin-1 receptor ELISA Kitis available at Gentaur for Next week Delivery. (researchd.com)
ANG22
- Angiopoietin-2 (ANG2) is a 56.9 kDa glycosylated growth factor that is specific for endothelial cells (ECs) https://www.uniprot.org/uniprot/O35608 ANG2 expressed in embryonic vessels and contributes to the formation of new vasculature. (tecomedical.com)
- Numerous vasoactive cytokines are upregulated during sepsis, including angiopoietin 2 (ANG2), which increases vascular permeability. (mpg.de)
Endothelial cell3
- All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. (elisa-kits.de)
- 2005). Angiopoietins activate TEK in a unique manner, which involves the translocation of TEK to endothelial cell-cell contacts, and TIE1 is also present in these complexes (Saharinen et al. (atlasgeneticsoncology.org)
- The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. (nih.gov)
Antagonist1
- A related protein, angiopoietin-2 (ang-2), has been identifiec s a naturally occurring antagonist of Ang-1 avtivation of Tie-2. (researchd.com)
Expression5
- Changes in expression of vascular endothelial growth factor and angiopoietin-1 and -2 in the macaque corpus luteum during the menstrual cycle. (oregonstate.edu)
- Using logistic regression analysis, we explored the relationships between plasma angiopoietin-2 levels, parasite VSA expression and the two syndromes of severe malaria, impaired consciousness and respiratory distress. (biomedcentral.com)
- In contrast, group A-like PfEMP1 expression and angiopoietin-2 maintained independent associations with impaired consciousness when adjusted for each other. (biomedcentral.com)
- Staton CA, Valluru M, Hoh L, Reed MWR & Brown NJ (2010) Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring. . (sheffield.ac.uk)
- Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival. (wikidata.org)
Gene2
- The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. (crcm-marseille.fr)
- Angiopoietin-1 receptor also known as CD202B ( cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene . (wikidoc.org)
Inhibits1
- Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases. (drugbank.com)
Soluble1
- In addition, the early-onset phenotype demonstrated higher plasma levels of soluble receptor for advanced glycation end-products and angiopoietin-2. (nih.gov)
Specificity1
- Specificity: Natural and recombinant Bovine Angiopoietin-1 receptor GeneName: TEK ProteinName: Angiopoietin-1 receptor Alternative: Endothelial tyrosine. (researchd.com)
Apoptosis1
- The secondary outcomes were increased vascular permeability (using angiopoietin-2 level), apoptosis (using annexin A5 level), and associated clinical changes. (bvsalud.org)
Peptibody2
- Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma. (umassmed.edu)
- Trebananib is an investigational peptibody designed to inhibit the angiopoietin axis. (takeda.com)
Plasma2
- We used plasma angiopoietin-2 as a marker of widespread endothelial activation. (biomedcentral.com)
- Plasma angiopoietin-2 was associated with both syndromes. (biomedcentral.com)
Tie11
- However, TIE1 tyrosine phosphorylation is induced by angiopoietin-1 (Saharinen et al. (atlasgeneticsoncology.org)
Protein called1
- One of these factors was a protein called angiopoietin-like 4. (nih.gov)
Receptors1
- Farmacologia de receptors NMDAR i funció en mutacions relacionades amb malalties neurològiques. (ub.edu)
Blood vessel1
- Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting. (nih.gov)