A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.
An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.
The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.
A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).
A TIE receptor found predominantly on ENDOTHELIAL CELLS. It is considered essential for vascular development and can form a heterodimer with the TIE-2 RECEPTOR. The TIE-1 receptor may play a role in regulating BLOOD VESSEL stability and maturation.
A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
Glycoproteins found on the membrane or surface of cells.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The carbohydrate-rich zone on the cell surface. This zone can be visualized by a variety of stains as well as by its affinity for lectins. Although most of the carbohydrate is attached to intrinsic plasma membrane molecules, the glycocalyx usually also contains both glycoproteins and proteoglycans that have been secreted into the extracellular space and then adsorbed onto the cell surface. (Alberts et al., Molecular Biology of the Cell, 3d ed, p502)
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
A cell line derived from cultured tumor cells.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.
Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Activities performed to identify concepts and aspects of published information and research reports.

Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (1/298)

Using homology-based PCR, we have isolated cDNA encoding a novel member (491 amino acids) of the angiopoietin (Ang) family from human adult heart cDNA and have designated it angiopoietin-3 (Ang3). The NH2-terminal and COOH-terminal portions of Ang-3 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in other known Angs. Ang3 has a highly hydrophobic region at the N-terminus (approximately 21 amino acids) that is typical of a signal sequence for protein secretion. Ang3 mRNA is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine in human adult tissues. Additionally, Ang3 is a secretory protein, but is not a mitogen in endothelial cells.  (+info)

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (2/298)

The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist, angiopoietin-2, both of which act by means of the Tie2 receptor. We now report our attempts to use homology-based cloning approaches to identify new members of the angiopoietin family. These efforts have led to the identification of two new angiopoietins, angiopoietin-3 in mouse and angiopoietin-4 in human; we have also identified several more distantly related sequences that do not seem to be true angiopoietins, in that they do not bind to the Tie receptors. Although angiopoietin-3 and angiopoietin-4 are strikingly more structurally diverged from each other than are the mouse and human versions of angiopoietin-1 and angiopoietin-2, they appear to represent the mouse and human counterparts of the same gene locus, as revealed in our chromosomal localization studies of all of the angiopoietins in mouse and human. The structural divergence of angiopoietin-3 and angiopoietin-4 appears to underlie diverging functions of these counterparts. Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist.  (+info)

Angiopoietin-3, a novel member of the angiopoietin family. (3/298)

A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2.  (+info)

Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. (4/298)

Using degenerate polymerase chain reaction, we isolated a cDNA encoding a novel 493-amino acid protein from human and mouse adult heart cDNAs and have designated it angiopoietin-related protein-2 (ARP2). The NH(2)-terminal and COOH-terminal portions of ARP2 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in angiopoietins. ARP2 has two consensus glycosylation sites and a highly hydrophobic region at the NH(2) terminus that is typical of a secretory signal sequence. Recombinant ARP2 expressed in COS cells is secreted and glycosylated. In human adult tissues, ARP2 mRNA is most abundant in heart, small intestine, spleen, and stomach. In rat embryos, ARP2 mRNA is most abundant in the blood vessels and skeletal muscles. Endothelial and vascular smooth muscle cells also contain ARP2 mRNA. Recombinant ARP2 protein induces sprouting in vascular endothelial cells but does not bind to the Tie1 or Tie2 receptor. These results suggest that ARP2 may exert a function on endothelial cells through autocrine or paracrine action.  (+info)

Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (5/298)

Using degenerate PCR we isolated a cDNA encoding a novel 406- and 410-amino acid protein from human and mouse embryonic cDNAs and have designated it 'hepatic fibrinogen/angiopoietin-related protein' (HFARP). The N-terminal and C-terminal portions of HFARP contain the characteristic coiled-coil domains and fibrinogen-like domains that are conserved in angiopoietins. In human and mouse tissues, HFARP mRNA is specifically expressed in the liver. HFARP mRNA and protein are mainly present in the hepatocytes. HFARP has a highly hydrophobic region at the N-terminus that is typical of a secretory signal sequence and one consensus glycosylation site. Recombinant HFARP expressed in COS-7 cells is secreted and glycosylated. HFARP protein is present not only in the hepatocytes, but also in the circulating blood. Recombinant HFARP acts as an apoptosis survival factor for vascular endothelial cells, but does not bind to Tie1 or Tie2 (endothelial-cell tyrosine kinase receptors). These results suggest that HFARP may exert a protective function on endothelial cells through an endocrine action.  (+info)

Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. (6/298)

The angiopoietins are recently described growth factors for vascular endothelium. The Tie1 and Tie2 receptors are expressed by endothelium. Acquired immune deficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS) and cutaneous angiosarcoma are malignancies of endothelial origin. KS involves primarily the skin and mucosal surfaces and is common in AIDS patients. In an effort to determine whether the angiopoietins and Tie receptors play a role in the pathobiology of angiosarcoma and KS, we studied the expression of angiopoietin-1, angiopoietin-2, angiopoietin-4, Tie1, and Tie2 mRNAs in biopsies of KS from 12 AIDS patients, in biopsies of cutaneous angiosarcoma from two patients, and in control biopsies of normal skin from three volunteers by in situ hybridization. Strong expression of angiopoietin-2, Tie1, and Tie2 mRNAs was detected in the tumor cells of KS and cutaneous angiosarcomas, in contrast to the focal low-level expression in normal skin biopsies. Focal low-level expression of angiopoietin-1 was seen in KS, cutaneous angiosarcomas, and in normal skin. Focal low-level expression of angiopoietin-4 was identified in a minority of KS lesions. These findings suggest that the angiopoietins and Tie receptors may play an important role in the pathobiology of KS and cutaneous angiosarcoma and identify additional potential targets for therapeutic intervention in these vascular malignancies.  (+info)

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. (7/298)

Fasting is associated with significant changes in nutrient metabolism, many of which are governed by transcription factors that regulate the expression of rate-limiting enzymes. One factor that plays an important role in the metabolic response to fasting is the peroxisome proliferator-activated receptor alpha (PPARalpha). To gain more insight into the role of PPARalpha during fasting, and into the regulation of metabolism during fasting in general, a search for unknown PPARalpha target genes was performed. Using subtractive hybridization (SABRE) comparing liver mRNA from wild-type and PPARalpha null mice, we isolated a novel PPARalpha target gene, encoding the secreted protein FIAF (for fasting induced adipose factor), that belongs to the family of fibrinogen/angiopoietin-like proteins. FIAF is predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. Moreover, FIAF mRNA is decreased in white adipose tissue of PPARgamma +/- mice. FIAF protein can be detected in various tissues and in blood plasma, suggesting that FIAF has an endocrine function. Its plasma abundance is increased by fasting and decreased by chronic high fat feeding. The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions.  (+info)

Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (8/298)

The nuclear receptor peroxisome proliferator-activated receptor gamma regulates adipose differentiation and systemic insulin signaling via ligand-dependent transcriptional activation of target genes. However, the identities of the biologically relevant target genes are largely unknown. Here we describe the isolation and characterization of a novel target gene induced by PPARgamma ligands, termed PGAR (for PPARgamma angiopoietin related), which encodes a novel member of the angiopoietin family of secreted proteins. The transcriptional induction of PGAR follows a rapid time course typical of immediate-early genes and occurs in the absence of protein synthesis. The expression of PGAR is predominantly localized to adipose tissues and placenta and is consistently elevated in genetic models of obesity. Hormone-dependent adipocyte differentiation coincides with a dramatic early induction of the PGAR transcript. Alterations in nutrition and leptin administration are found to modulate the PGAR expression in vivo. Taken together, these data suggest a possible role for PGAR in the regulation of systemic lipid metabolism or glucose homeostasis.  (+info)

Angiopoietin-like Protein 1/ANGPTL1 Proteins available through Novus Biologicals. Browse our Angiopoietin-like Protein 1/ANGPTL1 Protein catalog backed by our Guarantee+.
Synonyms: Angiopoietin-Like Protein 6, Angiopoietin-Related Protein 5, Angiopoietin-Related Growth Factor, Angiopoietin-Related Protein 6, AGF, ARP5.. ...
Angiopoietin-like protein 3(ANGPTL3) is well acknowledged as a key regulator of lipid metabolism. Now, there have not been enough data to explain the mechanism of hyperlipidemia related proteinuria. In this study, we hoped to investigate the changes of Angiopoietin-like protein 3(ANGPTL3) levels in hyperlipidemia patients with different proteinuria levels. Seventy-one patients with hyperlipidemia were selected, who were hospitalized in Gansu Provincial Peoples Hospital from September 2016 to September 2017, and 20 healthy people in the physical examination center were selected. We combed through medical history and conducted clinical biochemical indicators of blood urea nitrogen (BUN), serum creatinine (SCr), 24 h urine protein quantitation (24hUPro), cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low detection of density lipoproteins (LDL-C). The concentration of serum ANGPTL3 was measured by ELISA. 1. Serum ANGPTL3 in patients with hyperlipidemia related proteinuria was
Shop Angiopoietin-like protein ELISA Kit, Recombinant Protein and Angiopoietin-like protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene. Angiopoietin-like protein 2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas an excess of ANGPTL2 activation induced by prolonged stress promotes the breakdown of tissue homeostasis due to chronic inflammation, promoting the development of metabolic diseases. ANGPTL2 has a role also in angiogenesis, in tissue repair, in obesity, in atherosclerotic diseases and finally in cancerogenesis. Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. GRCh38: ...
Lipoprotein lipase (LPL) hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue. LPL in macrophages in the artery wall may, however, promote foam cell formation and atherosclerosis. Angiopoietin-like protein (ANGPTL) 4 inactivates LPL and ANGPTL4 expression is controlled by peroxisome proliferator-activated receptors (PPAR). The mechanisms for inactivation of LPL by ANGPTL4 was studied in THP-1 macrophages where active LPL is associated with cell surfaces in a heparin-releasable form, while LPL in the culture medium is mostly inactive. The PPAR delta agonist GW501516 had no effect on LPL mRNA, but increased ANGPTL4 mRNA and caused a marked reduction of the heparin-releasable LPL activity concomitantly with accumulation of inactive, monomeric LPL in the medium. Intracellular ANGPTL4 was monomeric, while dimers and tetramers of ANGPTL4 were present in the heparin-releasable fraction and medium. GW501516 caused an increase ...
Our products have been quoted by publications of Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: A brown adipose tissue-derived endocrine factor with a potential role in fetal growth from Translational Research.
Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA expression of the anti-apoptotic BCL-2 family
Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin β1 signaling in human hepatocellular ...
TY - JOUR. T1 - Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. AU - Kim, Injune. AU - Kim, Hwan Gyu. AU - Kim, Hyun. AU - Kim, Hong Hee. AU - Park, Sung Kwang. AU - Uhm, Chang Sub. AU - Lee, Zang Hee. AU - Koh, Gou Young. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 2000/3/15. Y1 - 2000/3/15. N2 - Using degenerate PCR we isolated a cDNA encoding a novel 406- and 410-amino acid protein from human and mouse embryonic cDNAs and have designated it hepatic fibrinogen/angiopoietin-related protein (HFARP). The N-terminal and C-terminal portions of HFARP contain the characteristic coiled-coil domains and fibrinogen-like domains that are conserved in angiopoietins. In human and mouse tissues, HFARP mRNA is specifically expressed in the liver. HFARP mRNA and protein are mainly present in the hepatocytes. HFARP has a highly hydrophobic region at the N-terminus that is typical of a ...
Angiopoietin-related protein 4 (406 aa, ~45 kDa) is encoded by the human ANGPTL4 gene. This protein plays a role in the modulation of signaling during hypoxic stress and angiogenesis.
Chronic vascular inflammation in coronary artery plays crucial roles in pathogenesis of coronary artery disease (CAD) through causing endothelial dysfunction and the progression of coronary atherosclerosis. Recently, we reported that adipose tissue-derived Angptl2 is a key mediator linking obesity to adipose tissue inflammation and systemic insulin resistance (Cell Metabolism 2009). Since angptl2 is also secreted from endothelial cells, and promotes vascular inflammation via the integrin α5β1/Rac1/NF-κB pathway, we investigated whether Angptl2 cause the coronary endothelial dysfunction and atherosclerosis in CAD. First, we compared circulating Angptl2 levels in 83 subjects with coronary endothelial dysfunction (CED) and 30 subjects with chest pain syndrome (CPS) of normal coronary endothelial function. We assessed coronary endothelial function by estimating the ratio of coronary blood flow in response to intracoronary injection of acetylcholine (ACh). Plasma Angptl2 concentrations were ...
Rabbit Polyclonal Anti-Angiopoietin-like Protein 5/ANGPTL5 Antibody. Validated: WB, ELISA. Tested Reactivity: Human. 100% Guaranteed.
Principal Investigator:KAGAMI Shoji, Project Period (FY):2011 - 2013, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Pediatrics
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
Sigma-Aldrich offers abstracts and full-text articles by [Dana Mahmood, Elena Makoveichuk, Solveig Nilsson, Gunilla Olivecrona, Bernd Stegmayr].
The fasting-induced adipose factor (FIAF, ANGPTL4, PGAR, HFARP) was previously identified as a novel adipocytokine that was up-regulated by fasting, by peroxisome proliferator-activated receptor agonists, and by hypoxia. To further characterize FIAF, we studied regulation of FIAF mRNA and protein in liver and adipose cell lines as well as in human and mouse plasma. Expression of FIAF mRNA was up-regulated by peroxisome proliferator-activated receptor α (PPARα) and PPARβ/δ agonists in rat and human hepatoma cell lines and by PPARγ and PPARβ/δ agonists in mouse and human adipocytes. Transactivation, chromatin immunoprecipitation, and gel shift experiments identified a functional PPAR response element within intron 3 of the FIAF gene. At the protein level, in human and mouse blood plasma, FIAF was found to be present both as the native protein and in a truncated form. Differentiation of mouse 3T3-L1 adipocytes was associated with the production of truncated FIAF, whereas in human white ...
TY - JOUR. T1 - Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise. AU - Abu-Farha, Mohamed. AU - Cherian, Preethi. AU - Al khairi, Irina. AU - Madhu, Dhanya. AU - Tiss, Ali. AU - Warsam, Samia. AU - Alhubail, Asma. AU - Sriraman, Devarajan. AU - Al-Refaei, Faisal. AU - Abubaker, Jehad. PY - 2017/3/1. Y1 - 2017/3/1. N2 - Objective ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. The biological role of ANGPTL7 is yet to be understood except for a recently proposed role in the pathophysiology of glaucoma. This study was designed to shed light on the function of ANGPTL7 in obesity and its modulation by physical exercise as well as its potential association with lipid profile. Methods A total of 144 subjects were enrolled in this study and finished three months of physical ...
Effective slimming actives should reduce lipogenesis, increase lipolysis, promote fatty acid release and improve skin firmness. Here, the authors describe the development of such an active based on polyglucuronic acid. Further, this material is shown to act on a new biological pathway involving the fasting-induced adipose factor (FIAF) adipokine.
Author(s): McQueen, Allison E; Kanamaluru, Deepthi; Yan, Kimberly; Gray, Nora E; Wu, Leslie; Li, Mei-Lan; Chang, Anthony; Hasan, Adeeba; Stifler, Daniel; Koliwad, Suneil K; Wang, Jen-Chywan | Abstract: Angptl4 (Angiopoietin-like 4) is a circulating protein secreted by white and brown adipose tissues and the liver. Structurally, Angptl4 contains an N-terminal coiled-coil domain (CCD) connected to a C-terminal fibrinogen-like domain (FLD) via a cleavable linker, and both full-length Angptl4 and its individual domains circulate in the bloodstream. Angptl4 inhibits extracellular lipoprotein lipase (LPL) activity and stimulates the lipolysis of triacylglycerol stored by adipocytes in the white adipose tissue (WAT). The former activity is furnished by the CCD, but the Angptl4 domain responsible for stimulating adipocyte lipolysis is unknown. We show here that the purified FLD of Angptl4 is sufficient to stimulate lipolysis in mouse primary adipocytes and that increasing circulating FLD levels in mice through
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Angiopoietin-like 4 (ANGPTL4) is involved in angiogenesis and lipid metabolism. It is secreted by liver and adipose tissues and cleaved to generate circulating coiled-coil domain (CCD) and fibrinogen-like domain (FLD) fragments. The full-length ANGPTL4 produced by hypoxic endothelial cells interacts with the extracellular matrix (ECM). The ECM-bound and soluble forms of ANGPTL4 have antiangiogenic properties. We carried out a structure-function analysis to investigate the regulation of ANGPTL4 bioactivity in endothelial cells. We found that the recombinant CCD binds to the ECM, whereas the FLD is released into the medium. The CCD, like the full-length ANGPTL4, binds to heparan and dermatan sulfates in surface plasmon resonance assays and inhibits endothelial cell adhesion, motility, and tubule-like formation. In endothelial cells, ANGPTL4 is processed in the secretion medium after release from the ECM. This processing is altered by the proprotein convertases inhibitor alpha1-PDX and abolished by the
Objective: Lipoprotein lipase (LPL) is a key regulator of circulating triglyceride rich lipoprotein hydrolysis. In brain LPL regulates appetite and energy expenditure. Angiopoietin-like 4 (Angptl4) is a secreted protein that inhibits LPL activity and, thereby, triglyceride metabolism, but the impact of Angptl4 on central lipid metabolism is unknown. Methods: We induced type 1 diabetes by streptozotocin (STZ) in whole-body Angptl4 knockout mice (Angptl4-/-) and their wildtype littermates to study the role of Angptl4 in central lipid metabolism. Results: In type 1 (streptozotocin, STZ) and type 2 (ob/ob) diabetic mice, there is a ~2-fold increase of Angptl4 in the hypothalamus and skeletal muscle. Intracerebroventricular insulin injection into STZ mice at levels which have no effect on plasma glucose restores Angptl4 expression in hypothalamus. Isolation of cells from the brain reveals that Angptl4 is produced in glia, whereas LPL is present in both glia and neurons. Consistent with the in vivo ...
Objective: Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development. Approach and Results: Macrophage activation elicited by pathogen-recognition receptor agonists decreased Angptl4 expression, whereas lipid loading by intralipid and oxidized low-density lipoprotein increased Angptl4 expression. Consistent with an antilipotoxic role of Angptl4, recombinant Angptl4 significantly decreased uptake of oxidized low-density lipoprotein by macrophages, via lipolysis-dependent and -independent mechanisms. Angptl4 protein was detectable in human atherosclerotic lesions and localized to macrophages. Transgenic overexpression of Angptl4 in atherosclerosis-prone ...
BACKGROUND:Angiopoietin-like 4 (ANGPTL4) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to evaluate the preventive effects of ANGPTL4 on the formation of brain edema and to determine whether it promotes the recovery of neurological function following intracerebral hemorrhage (ICH). MATERIAL AND METHODS:Recombinant human ANGPTL4 (rhANGPTL4; 40 µg/kg) or a vehicle was administered intraperitoneally 5 min prior to bacterial collagenase-induced ICH in male C57/B6J mice. Behavioral tests were performed prior to ICH and at days 1, 3, 7, 14, 21, and 28 after ICH. Brain edema and hematoma volume were examined separately using the wet weight/dry weight method and hematoxylin-eosin staining. The integrity of the tight and adherens junctions was quantified via immunofluorescence. The ultrastructure of the blood-brain barrier (BBB) was examined using transmission electron microscopy. Vascular endothelial (VE)-cadherin, claudin-5, Src, and
The ANGPTL4 Human Recombinant is manufactured with C-terminal fusion of 11 amino acid FLAG Tag. The ANGPTL4 Flag -Tagged Fusion Protein is a 44.2kDa protein containing 392 amino acid residues of the Angiopoietin-like Protein 4 and 11 additional amin
Model of tumor cell resistance to antineoplastic therapy through angiopoietin-like protein 2 (ANGPTL2) expression. Tumor cell-secreted ANGPTL2 induces spleen ty
The angiopoietin-like protein ANGPTL8 (A8) is one of three ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is expressed in liver and adipose tissue, is required to redirect dietary TG from oxidative to storage tissues following food intake. Here we show that A8 from liver and adipose tissue have different roles in this process. Mice lacking hepatic A8 have no circulating A8, high intravascular LPL activity, low plasma TG levels, and evidence of decreased delivery of dietary lipids to adipose tissue. In contrast, mice lacking A8 in adipose tissue have higher postprandial TG levels and no alteration in fatty acid composition in adipocytes. Expression of A8, together with A4, in cultured cells reduced A4 secretion and A4-mediated LPL inhibition. Thus, hepatic A8 (with A3) acts in an endocrine fashion to inhibit intravascular LPL in oxidative tissues, ...
LPL is a key regulator of fatty acid release from triglyceride-rich lipoproteins in muscle, heart, and fat (22). Increased adipocyte LPL activity leads to increased cellular uptake of fatty acids and adipocyte triglyceride accumulation. In white fat, LPL is regulated posttranscriptionally by nutritional status: fasting reduces and refeeding increases enzyme activity (23). Intriguingly, we found that a 14-d conventionalization increased LPL activity 122% in epididymal fat pads (Fig. 4C ). Moreover, the effect was not confined to fat: enzymatic assays of heart revealed a 99% increase with conventionalization (Fig. 4C ). Increased insulin levels produce reductions in muscle LPL activity (24). Therefore, our findings indicated that the microbiota induces the observed general increase in LPL through another mechanism.. Fiaf, also known as angiopoietin-like protein 4, is produced by brown and white fat, liver, and intestine (13, 25, 26). This secreted protein is an inhibitor of LPL in vitro [IC50 = ...
Chronic exposure of pancreatic β-cells to saturated non-esterified fatty acids can lead to inhibition of insulin secretion and apoptosis. Several previous studies have demonstrated that saturated fatty acids such as PA (palmitic acid) are detrimental to β-cell function compared with unsaturated fatty acids. In the present study, we describe the effect of the polyunsaturated AA (arachidonic acid) on the function of the clonal pancreatic β-cell line BRIN-BD11 and demonstrate AA-dependent attenuation of PA effects. When added to β-cell incubations at 100 μM, AA can stimulate cell proliferation and chronic (24 h) basal insulin secretion. Microarray analysis and/or real-time PCR indicated significant AA-dependent up-regulation of genes involved in proliferation and fatty acid metabolism [e.g. Angptl (angiopoietin-like protein 4), Ech1 (peroxisomal Δ 3,5 ,Δ 2,4 -dienoyl-CoA isomerase), Cox-1 (cyclo-oxygenase-1) and Cox-2 , P ,0.05]. Experiments using specific COX and LOX (lipoxygenase) ...
Podocyte injury plays central roles in proteinuria and kidney dysfunction, therefore, identifying specific biomarker to evaluate earlier podocyte injury is highly desirable. Podocyte-secreted angiopoietin-like-4 (Angptl4) mediates proteinuria in different types of podocytopathy. In the present study …
The majority of patients with diabetic macular edema (DME), the most common cause of vision loss in working-age Americans, do not respond adequately to current therapies targeting VEGFA. Here, we show that expression of angiopoietin-like 4 (ANGPTL4), a HIF-1-regulated gene product, is increased in the eyes of diabetic mice and patients with DME. We observed that ANGPTL4 and VEGF act synergistically to destabilize the retinal vascular barrier. Interestingly, while ANGPTL4 modestly enhanced tyrosine phosphorylation of VEGF receptor 2, promotion of vascular permeability by ANGPTL4 was independent of this receptor. Instead, we found that ANGPTL4 binds directly to neuropilin 1 (NRP1) and NRP2 on endothelial cells (ECs), leading to rapid activation of the RhoA/ROCK signaling pathway and breakdown of EC-EC junctions. Treatment with a soluble fragment of NRP1 (sNRP1) prevented ANGPTL4 from binding to NRP1 and blocked ANGPTL4-induced activation of RhoA as well as EC permeability in vitro and retinal ...
Previously, I discussed how important gut microbiota is in disease condition and how it may contribute to TLR4 signaling pathway. In todays post, I will discuss how gut microbiome can affect lipid metabolism.. Several studies supported a role for gut microbiota in the modulation of lipid metabolism1-3. In one of the early studies on this topic, Jeffrey Gordon group were able to show that conventialization of adult GF C57BL/6 mice with a normal microbiota resulted in a 60% increase in body fat content despite reduced food intake2. Further, they were able to demonstrate that Fasting-induced adipocyte factor (Fiaf) - also known as Angiopoietin-like 4 (ANGPTL4), a member of angiopoietin-like family of proteins, is suppressed in the intestine of normal mice after conventialization2. Their data from fiaf -/- mice also revealed that Fiaf is a LPL inhibitor and its suppression is needed for gut microbiota-induced deposition of triglyceride in adipose tissue. Continuing to further support the merging ...
MODULATION OF ALTERNATIVE MDM2 SPLICING | FACTOR V/Va-TARGETING APTAMER COMPOSITONS AND METHODS OF USING THE SAME | COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS | TREATMENT OF SODIUM CHANNEL, VOLTAGE-GATED, ALPHA SUBUNIT (SCNA) RELATED DISEASES BY INHIBITION OF NATURAL... | RNAI INDUCED HUNTINGTIN GENE SUPPRESSION |
Cells released from primary tumors seed metastases to specific organs by a nonrandom process, implying the involvement of biologically selective mechanisms. Based on clinical, functional, and molecular evidence, we show that the cytokine TGFbeta in the breast tumor microenvironment primes cancer cel …
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
ANGPTL4 - ANGPTL4 (Myc-DDK-tagged)-Human angiopoietin-like 4 (ANGPTL4), transcript variant 3 available for purchase from OriGene - Your Gene Company.
Angptl4 - Angptl4 (Myc-DDK-tagged ORF) - Rat angiopoietin-like 4 (Angptl4), (10 ug) available for purchase from OriGene - Your Gene Company.
The aim of the present study was to examine the association of angiopoietin-like proteins-8 (ANGPTL8) rs2278426, cholesteryl ester-transfer protein (CETP) rs708272 and endothelial nitric oxide synthase (NOS3) rs1799983 variants with type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), and to investigate the effect of the potential interaction between these variants on disease risk. Our study included 272 subjects classified into 68 patients with T2DM, 68 patients with T2DM complicated with CVD and 136 control subjects. ANGPTL8 c194C|T, CETP Taq1B and NOS3 G894T polymorphisms were genotyped using TaqMan® SNP Genotyping Assay. The presence of NOS3, ANGPTL8, and homozygous CETP B1 variants were associated with increased risk of T2DM by 3.07-, 2.33- and 1.75-fold, respectively. NOS3 variant was associated with 3.08-fold increased risk of CVD (95% CI 1.70-5.60), while ANGPTL8 C allele was associated with 2.8-fold increased risk of CVD in T2DM patients (95% CI 1.13-6.97). Concomitant presence of
The angiopoietin-like 4 (ANGPLT4) protein is involved in lipid metabolism and is known to inhibit lipoprotein lipase in the bloodstream. We investigated the effect of milk on intestinal ANGPTL4 and the metabolic profile of growing pigs and the effect of free fatty acids (FFAs) on ANGPTL4 in ex vivo and in vitro assays. Feeding pigs whole milk increased intestinal ANGPTL4 mRNA and increased fecal excretion of long-chain FFA compared to the control group fed soybean oil (n = 9). Furthermore, FFAs (C4-C8) induced ANGPTL4 gene expression in porcine intestinal tissue mounted in Ussing chambers and ANGPTL4 protein secretion to both the apical and basolateral sides of intestinal Caco-2 cells on permeable membranes ...
Rabbit polyclonal antibody raised against a full-length human ANGPTL3 protein. ANGPTL3 (NP_055310.1, 1 a.a. ~ 460 a.a) full-length human protein. (H00027329-D01P) - Products - Abnova
Targeting the blood-vessel-growth protein angiopoietin-like 4 (ANGPTL4) along with anti-vascular endothelial growth factor (VEGF) therapy could increase the effectiveness of treatments for the prevention of proliferative diabetic retinopathy (PDR), according to researchers at The Johns Hopkins University and the University of Maryland.
We are using a multidisciplinary approach combining gene discovery approach for complex human diseases, vascular cell biology (endothelial and smooth muscle cells) cell cultures in 2-D and 3-D, biochemistry, molecular biology, various imaging approaches (confocal analyses, videomicroscopy), gene expression analyses, protein production, and preclinical models of human diseases. Our efforts have recently been focused on characterizing the role of Thrombospondin-1, Angiopoietin-like 4 and Lysysl Oxidase like 2 in regulating angiogenesis and vascular integrity.. By gain-of-function and loss-of-function approaches, both in vitro and in vivo, we are also studying ECM composition, deposition, posttranslational modifications and rearrangement by ECs. Indeed, hypoxia-driven vascular remodeling is dynamically regulated through activities of ECM modifying enzyme, such as Lysysl Oxidase like 2 or Transgluaminase-2 that eventually regulate both matricellular proteins and growth factor availability, that ...
Human ANGPTL3 partial ORF ( NP_055310.1, 361 a.a. - 460 a.a.) recombinant protein with GST-tag at N-terminal. (H00027329-Q01) - Products - Abnova
La dérégulation de la formation et lintégrité des vaisseaux sanguins peut conduire à un état pathologique tel quobservé dans de nombreuses maladies ischémiques telles que: la croissance de tumeur solide, larthrite rhumatoïde, le psoriasis, les rétinopathies et lathérosclérose. Par conséquent, la possibilité de moduler langiogenèse régionale chez les patients souffrant dischémie est cliniquement pertinente. Un élément clé dans linduction de langiogenèse pathologique est une inflammation qui précède et accompagne la formation des nouveaux vaisseaux. Ce phénomène est démontré par laugmentation de la perméabilité vasculaire et le recrutement de monocytes/ macrophages et cellules polynucléaires (neutrophiles). En collaboration avec dautres groupes, nous avons montré que différents facteurs de croissance tels que le facteur de croissance endothélial vasculaire et les angiopoïétines peuvent non seulement promouvoir langiogenèse mais aussi induire diverses ...
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TY - JOUR. T1 - Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents. AU - Hammad, Maha M. AU - Abu-Farha, Mohamed. AU - Al-Taiar, Abdullah. AU - Alam-Eldin, Nada. AU - Al-Sabah, Reem. AU - Shaban, Lemia. AU - Al-Mulla, Fahd. AU - Abubaker, Jehad. AU - Rahman, Abdur. PY - 2020/4/14. Y1 - 2020/4/14. N2 - Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to regulate triglyceride metabolism and is increased in obesity and diabetes. However, its role in metabolic diseases in adolescents is not well-studied. In this study, we tested the hypothesis of a positive association between plasma ANGPTL5, and obesity, high sensitivity C-reactive protein (HsCRP) and oxidized low-density lipoprotein (Ox-LDL) in adolescents. Adolescents (N = 431; age 11-14 years) were randomly selected from middle schools in Kuwait. Obesity ...
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor. Since differentiation can attenuate or halt the growth of tumor cells, an image-based phenotypic screening was performed to find out drugs inducing morphological differentiation of GBMs. Bexarotene, a selective retinoid X receptor agonist, showed strong inhibition of neurospheroidal colony formation and migration of cultured primary GBM cells. Bexarotene treatment reduced nestin expression, while significantly increasing glial fibrillary acidic protein (GFAP) expression. The effect of bexarotene on gene expression profile was compared with the activity of all-trans retinoic acid (ATRA), a well-known differentiation inducer. Both drugs largely altered the gene expression pattern into a tumor-ameliorating direction. These drugs increased the gene expression levels of Kruppel-like factor 9 (KLF9), regulator of G-protein signaling 4 (RGS4), growth differentiation factor 15 (GDF15), angiopoietin-like protein 4 (ANGPTL4), and ...
Detect and quantitate human angiopoietin-like 3 protein (ANGPTL3) in buffered solution and cell culture supernatants using a homogeneous LANCE Ultra TR-FRET assay.
Detect and quantitate human angiopoietin-like 3 protein (ANGPTL3) in buffered solution and cell culture supernatants using a homogeneous LANCE Ultra TR-FRET assay.
Expression of ANGPTL2 (ARP2, HARP) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
ANGPTL7 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 324 amino acids (22-337 a.a.) and having a molecular mass of 37.5kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).
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/PRNewswire/ - AGF Management Limited (AGF) is pleased to announce the appointment of Christopher Adey as Vice-President of Global Consultant Relations, AGF...
The International Federation of Film Archives (FIAF) brings together institutions dedicated to rescuing of films both as art and as historical documents
The International Federation of Film Archives (FIAF) brings together institutions dedicated to rescuing of films both as art and as historical documents
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model. ...
Mensagem com vírus enviada aparentemente pelo remetente indicado. --- Scan information follows --- Result: Virus Detected Virus Name: [email protected] File Attachment: document_all02c.zip Attachment Status: deleted --- Original message information follows --- From: [email protected] To: [email protected] Date: Fri, 23 Apr 2004 18:35:03 -0300 Subject: Re: Hi Received: from agf2.agf.com.br ([128.250.115.2]) by agfrelay.agf.com.br (SAVSMTP 3.1.5.43) with SMTP id M2004042318393326700 for ,[email protected],; Fri, 23 Apr 2004 18:39:33 -0300 ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin 2. antagonist of angiopoietin 1. TSP-1 and TSP-2. inhibit cell migration, cell proliferation, cell adhesion and ...
Activation of the Tie2 receptor by the ligand Angiopoietin 2. This has been shown in vitro and in vivo. Activation of the ... Activation of the signaling pathway by Delta4, Angiopoietin 2, insulin, or a combination of the three and a JAK inhibitor ... Angiopoietin 2). Hes3, in turn, by regulating the expression of Shh and potentially other factors, can also exert an effect on ... Angiopoietin 2, insulin, or a combined treatment consisting of all three factors and an inhibitor of JAK) induce the increase ...
Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ...
Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene. Angiopoietins are proteins with important roles in ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3-4): 147-54. ... "Entrez Gene: ANGPT4 angiopoietin 4". Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser. ...
July 2007). "Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin ... Angiopoietin-like 4 is a protein that in human is encoded by the ANGPTL4 gene. Alternatively spliced transcript variants ... July 2017). "Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen ... June 2015). "Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative ...
Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene. The protein encoded by ... "Entrez Gene: ANGPTL3 angiopoietin-like 3". Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, et al. (December ... The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced ... Kaplan R, Zhang T, Hernandez M, Gan FX, Wright SD, Waters MG, Cai TQ (January 2003). "Regulation of the angiopoietin-like ...
It targets the protein angiopoietin 2. As of May 2017[update], it is in Phase II clinical trials for the treatment of diabetic ... "Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of ...
Three dimensional structure of none of the members of Angiopoietin like proteins (ANGPTLs) is available up till now. However, ... "Atypical angiopoietin-like protein that regulates ANGPTL3". Proceedings of the National Academy of Sciences of the United ... is a novel but atypical member of the angiopoietin-like protein family". Biochemical and Biophysical Research Communications. ... "Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways". Genomics. ...
"Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization". Circulation Research. 83 (3): 233-40. ... Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the ... Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (November 2001). "Dok-R plays a pivotal role in angiopoietin-1- ...
Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 ... Xu Y, Yu Q (September 2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its ... Cheung AH, Stewart RJ, Marsden PA (March 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 ( ... "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ...
Li, J. J.; Huang, Y. Q.; Basch, R.; Karpatkin, S. (February 2001). "Thrombin induces the release of angiopoietin-1 from ... Angiopoietin-1[53]) and cytokines including the EMT inducer TGF-β.[54] The release of TGF-β by platelets in blood vessels near ...
The angiopoietins, Ang1 and Ang2, are required for the formation of mature blood vessels, as demonstrated by mouse knock out ... Thurston G (October 2003). "Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis". ...
... binds to the angiopoietin-like protein 3 (ANGPTL3). ANGPTL3 slows the function of certain enzymes that break down ...
Angiopoietin 2 can act as an antagonist to Tie-2, destabilizing the endothelial cells, which results in less endothelial cell ... Angiopoietin 1 and Tie-2 signaling is essential for maturation and stabilization of endothelial cells. Platelet-derived growth ... Similar to the inhibition of the PDGF pathway, angiopoietin 2 reduces levels of pericytes, leading to diabetic retinopathy. ... "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...
Chugh, S; Macé, C; Clement, L; Del Nogal, A; Marshall, C (2014). "Angiopoietin-like 4 based therapeutics for proteinuria and ...
Angiopoietin (Ang). *Autocrine motility factor. *Bone morphogenetic proteins (BMPs). *Ciliary neurotrophic factor family * ...
"Attenuated angiopoietin-Tie2 signaling regresses Schlemm's canal integrity and induces glaucoma". Journal of Clinical ...
... and angiopoietins, that play the key roles in the blood vessel formation. National Science Contest for Elementary School ... "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis". Cell. 87 (7): 1171-1180. doi: ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...
Zeng L, Dai J, Ying K (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet ...
Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). "Angiopoietin-1 ...
Angiopoietin-1 and angiopoietin-2 can form dimers, trimers, and tetramers. Angiopoietin-1 has the ability to form higher order ... is demonstrated by an increased ratio of angiopoietin-2 and angiopoietin-1 in blood serum. To be specific, angiopoietin levels ... Angiopoietin-1 encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa whereas angiopoietin-2 encodes a 496 ... Angiopoietin-2 has been proposed as a biomarker in different cancer types. Angiopoietin-2 expression levels are proportional to ...
The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind ... The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis). The angiopoietins are ... In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4). Ang1 and ... But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.[citation ...
2009) Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in ... 2007) Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 ... Angiopoietin-like protein 8. Fabiana Quagliarini, Yan Wang, Julia Kozlitina, Nick V. Grishin, Rhonda Hyde, Eric Boerwinkle, ... Angiopoietin-like protein 8. Fabiana Quagliarini, Yan Wang, Julia Kozlitina, Nick V. Grishin, Rhonda Hyde, Eric Boerwinkle, ...
Angiopoietins are vascular factors essential for blood vessel assembly and correct organization and maturation. This study ... Regulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling Pathways. Irene Pafumi,1 Annarita Favia ... was found to modulate in vitro angiogenic responses to Angiopoietins in a specific way. 2-APB and 8Br-cADPR impaired the ... describes a novel calcium-dependent machinery activated through Angiopoietin-1/2-Tie receptor system in HUVECs monolayer. Both ...
Angiopoietin-related growth factor (AGF), a member of the angiopoietin-like protein (Angptl) family, is secreted predominantly ... Angiopoietin-related growth factor antagonizes obesity and insulin resistance.. Oike Y1, Akao M, Yasunaga K, Yamauchi T, ...
The angiopoietin/Tie (ANG/Tie) receptor system controls developmental and tumor angiogenesis, inflammatory vascular remodeling ... Fluorescence energy transfer between Tie1 and Tie2 after angiopoietin stimulation of endothelial cells. ...
Buy our Human Angiopoietin 2 peptide. Ab172727 is a blocking peptide for ab125692 and has been validated in BL. Abcam provides ... Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be ...
Buy our Recombinant human Angiopoietin 1 protein. Ab69492 is an active full length protein produced in HeLa cells and has been ... Recombinant human Angiopoietin 1 protein. See all Angiopoietin 1 proteins and peptides. ...
Angiopoietin-1 for Myocardial Angiogenesis , IntechOpen, Published on: 2011-10-21. Authors: Vien Khach Lai, Muhammad Zeeshan ... Angiopoietin-1 for Myocardial Angiogenesis. By Vien Khach Lai, Muhammad Zeeshan Afzal, Muhammad Ashraf and Khawaja Husnain ...
Open Access , Dysregulation of Angiopoietins Is Associated with Placental Malaria and Low Birth Weight. March 12, 2010 - 15:43 ... These data support the hypothesis that dysregulation of angiopoietins is associated with PM and LBW outcomes, and suggest that ... Read more about Open Access , Dysregulation of Angiopoietins Is Associated with Placental Malaria and Low Birth Weight ...
Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of ...
Plasma angiopoietin-1, angiopoietin-2, angiopoietin receptor tie-2, and vascular endothelial growth factor levels in acute ... Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction. Seung-Jun Lee,1 Choong-kun Lee,1,2 ... Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population. Eur J Heart Fail. 2013;15(12): ... Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med. 2006 ...
Compare Angiopoietin-like 7 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, ... Angiopoietin-like 7 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for ... Your search returned 59 Angiopoietin-like 7 ELISA ELISA Kit across 6 suppliers. ...
2012) The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway. Cold Spring Harb Perspect Med 2:a006550. ... 2007) Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2. BMC Cell ... 2011) Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest 121:2278- ... 2006) Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med ...
The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr ... Tie receptors and their angiopoietin ligands have important functions during embryonic vessel assembly and maturation, and ... Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... Biological characterization of angiopoietin-3 and angiopoietin-4. FASEB J. 18, 1200-1208 (2004). ...
Baseline angiopoietin 1 levels correlated with numbers of circulating endothelial cells. Low angiopoietin 2 level increased the ... The median concentration of angiopoietin 1 at the time of apheresis was lower than that at baseline (2.7 vs 7.8 ng/mL, p. ... The aim of our study was to evaluate the levels of cytokines (osteopontin and angiopoietins 1 and 2) active in the bone marrow ... Angiopoietins in haematopoietic stem cell mobilisation in patients with haematological malignancies.. [Anna Szmigielska-Kaplon ...
... angiopoietin-1 (Ang-1)] and receptor antagonists [angiopoietin-2 (Ang-2)] (7-10). The VEGFs and the angiopoietins seem to play ... A complete description of angiopoietin expression in human glioblastomas can be found at Science Online (Web Fig. 3 at www. ... The pro-angiogenic vascular endothelial growth factors (VEGFs) and the angiopoietins are the only known growth factor families ... A diagram depicting the complementary and coordinated roles of VEGF and the angiopoietins during vascular growth and ...
Tag: Plasma angiopoietin-2. (icTV) CLINICAL TRIALS RESULTS ~ Plasma angiopoietin-2 & ARDS risk in sepsis. Posted on 22 October ... Posted in ARF, Article links, ICM News, icTV Footage, SISTagged ards, congress, esicm, LIVES, Plasma angiopoietin-2, RCT, ... Resources , News , (icTV) CLINICAL TRIALS RESULTS ~ Plasma angiopoietin-2 & ARDS risk in sepsis. (icTV) CLINICAL TRIALS RESULTS ... icTV) CLINICAL TRIALS RESULTS Plasma angiopoietin-2 & ARDS risk in sepsis In this icTV interview, presenter John Reilly ...
Browse our Angiopoietin-2 Antibodies all backed by our Guarantee+. ... anti-angiopoietin 2 antibody, anti-angiopoietin-2a antibody, anti-angiopoietin-2B antibody, anti-angiopoitin 2 antibody, anti- ... Alternate Names for Angiopoietin-2 Antibodies. anti-Angiopoietin-2 antibody, anti-ANGPT2 antibody, anti-AGPT2 antibody, anti- ... Angiopoietin-2 Antibodies. We offer Angiopoietin-2 Antibodies for use in common research applications: ELISA, ELISA Capture ( ...
ANGPTL4 is also known as angiopoietin-like 4, angiopoietin-related protein 4 (ARP4), hepatic fibrinogen/angiopoietin-related ... Angiopoietin-Like Protein Detection. Angiopoietin-like proteins are a family of secreted glycoproteins that have strong ... ANGPTL2 is also known as angiopoietin-like 2, angiopoietin-related protein 2 (ARP2), and HARP. ... ANGPTL3 is also known as angiopoietin-like 3, angiopoietin-5 (ANGPT5), ANG-5, and FHBL2. ...
"Biological characterization of angiopoietin-3 and angiopoietin-4.". Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S. ... "Biological characterization of angiopoietin-3 and angiopoietin-4.". Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S. ... sp,Q9WVH6,ANGP4_MOUSE Angiopoietin-4 OS=Mus musculus OX=10090 GN=Angpt4 PE=1 SV=1 ...
Angiopoietin-1 Uncouples the VEGF Receptor from Src Message Subject. (Your Name) has forwarded a page to you from Science ... J. S. Gutkind, Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev. Cell 14, 25 ... Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) play complementary roles in vascular development during ...
The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind ... Angiopoietins. The angiopoietins are protein growth factors that regulate angiogenesis, the formation of blood vessels. In ... Angiopoietin#Tie_pathway. External links. *TIE+Receptor+Tyrosine+Kinases at the US National Library of Medicine Medical Subject ... But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.[citation ...
View our 7 Angiopoietin-2 products for your research including Angiopoietin-2 Proteins and Enzymes and Angiopoietin-2 Primary ... Angiopoietin-2: Products. Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that regulates vascular remodeling by ...
Angiopoietin-2 (Ang-2) modulates Tie-2 receptor activation. In mouse kidney maturation, Ang-2 is expressed in arteries, with ... Angiopoietin-2 (Ang-2) modulates Tie-2 receptor activation. In mouse kidney maturation, Ang-2 is expressed in arteries, with ... Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice Am J Pathol. 2004 Dec;165(6):1895- ...
Expression of angiopoietin 1 and 2 in ectopic endometrium on the chicken chorioallantoic membrane. Drenkhahn, M., Gescher, D.M ... Expression of angiopoietin 1 and 2 in ectopic endometrium on the chicken chorioallantoic membrane [1]. ... OBJECTIVE: To investigate the role of angiopoietin 1 and 2 (ANGPT1/ANGPT2) in angiogenesis of the ectopic endometrium as a ... Gene expression of members of the VEGF and Angiopoietin families of angiogenic growth factors has been linked to haemorrhaging ...
The purpose of this work was to determine if and where Angiopoietin-like genes are expressed in the mouse uterus during the ... Katoh Y, Katoh M (2006) Comparative integromics on Angiopoietin family members. Int J Mol Med 17:1145-1149PubMedGoogle Scholar ... Zeng L, Dai J, Ying K, Zhao E, Jin W, Ye Y, Xu J, Xie Y, Mao Y (2003) Identification of a novel human angiopoietin-like gene ... Xu A, Lam MC, Chan KW, Wang Y, Zhang J, Hoo RL, Xu JY, Chen B, Chow WS, Tso AW, Lam KS (2005) Angiopoietin-like protein 4 ...
... Cell. 2008 Apr 4;133(1):66-77. doi: ... Central to this process is the induction of angiopoietin-like 4 (ANGPTL4) by TGFbeta via the Smad signaling pathway. TGFbeta ...
Angiopoietin-related protein 7Add BLAST. 316. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... sp,Q8R1Q3,ANGL7_MOUSE Angiopoietin-related protein 7 OS=Mus musculus OX=10090 GN=Angptl7 PE=2 SV=1 ...
Response of angiopoietin-like proteins 3 and 4 to hemodialysis.. [Dana Mahmood, Elena Makoveichuk, Solveig Nilsson, Gunilla ... Patients on chronic hemodialysis (cHD) have decreased activity of lipoprotein lipase (LPL). Angiopoietin-like proteins (ANGPTL ...
  • The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis). (wikipedia.org)
  • The angiopoietins are protein growth factors that regulate angiogenesis, the formation of blood vessels. (wikipedia.org)
  • Angiopoietin-related growth factor (AGF), a member of the angiopoietin-like protein (Angptl) family, is secreted predominantly from the liver into the systemic circulation. (nih.gov)
  • Angiopoietin-like protein 2 (ANGPTL2) is believed to induce sprouting in endothelial cells through autocrine and paracrine actions. (clontech.com)
  • ANGPTL2 is also known as angiopoietin-like 2, angiopoietin-related protein 2 (ARP2), and HARP. (clontech.com)
  • The FBN domain in angiopoietin-like protein 3 (ANGPTL3) interacts with alpha-5 and beta-3 integrins, leading to induction of endothelial cell adhesion and migration. (clontech.com)
  • Angiopoietin-like protein 4 (ANGPTL4) is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. (clontech.com)
  • ANGPTL4 is also known as angiopoietin-like 4, angiopoietin-related protein 4 (ARP4), hepatic fibrinogen/angiopoietin-related protein (HFARP1), peroxisome proliferator-activated receptor (PPAR), PPAR gamma angiopoietin-related protein (PGAR), fasting-induced adipose factor (FIAF), NL2, and pp1158. (clontech.com)
  • Due to this increased expression and the fact that angiopoietin-like 4 protein plays a role in lipid metabolism and angiogenesis in other tissues, only the expression of Angptl4 was further examined in the uterus and developing placenta. (springer.com)
  • We offer Angiopoietin-like Protein 6/ANGPTL6 Peptides and Angiopoietin-like Protein 6/ANGPTL6 Proteins for use in common research applications: ELISA, Protein Array, Western Blot. (novusbio.com)
  • Our Angiopoietin-like Protein 6/ANGPTL6 Peptides and Angiopoietin-like Protein 6/ANGPTL6 Proteins can be used in a variety of model species: Human. (novusbio.com)
  • Choose from our Angiopoietin-like Protein 6/ANGPTL6 Peptides and Proteins. (novusbio.com)
  • Zusätzlich bieten wir Ihnen Angiopoietin-Like 1 Antikörper (117) und Angiopoietin-Like 1 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • Angiopoietin-related protein 4 (406 aa, ~45 kDa) is encoded by the human ANGPTL4 gene. (semanticscholar.org)
  • Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity. (semanticscholar.org)
  • Angiopoietin-like protein 4 (ANGPTL4) has been associated with a variety of diseases. (semanticscholar.org)
  • Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4. (semanticscholar.org)
  • The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. (semanticscholar.org)
  • Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4. (semanticscholar.org)
  • Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4. (semanticscholar.org)
  • The team identified the protein Angiopoietin-like 4 (ANGPTL4) in a mouse model. (cosmeticsandtoiletries.com)
  • mRNA expression of ovine angiopoietin-like protein 4 gene in adipose tissues. (thefreelibrary.com)
  • A gene on chromosome 8q23.1 that encodes angiopoietin 2, a secreted glycoprotein which, like other angiopoietins, binds to endothelial cell-specific tyrosine-protein kinase receptor. (thefreedictionary.com)
  • To examine the roles of angiopoietin like protein 2 (Angptl2) in corneal neovascularization using transgenic mice expressing Angptl2 driven by cytokeratin 14 (K14, K14-Angptl2 mice). (arvojournals.org)
  • Understanding the Ang-Tie interaction by manipulation of the angiopoietins is a very desirable prospect for developing it as a protein therapeutic drug. (bl.uk)
  • Angiopoietin-like protein 4 (ANGPTL4), also known as PPARγ angiopoietinrelated protein, fastinginduced adipose factor, or hepatic fibrinogen /angiopoietin-related protein (HFARP), is a secreted adipokine predominantly expressed in adipose tissue and liver. (creative-biogene.com)
  • Anti-Angiopoietin-2, rabbit polyclonal, recognizes the ~55 kDa non-glycosylated and the ~70 kDa glycosylated, secreted Ang-2 protein. (emdmillipore.com)
  • The immunogenic peptide sequence is 71% (15/21 amino acids) conserved in the human angiopoietin-2 protein. (emdmillipore.com)
  • Angiopoietin-like 4 (Angptl4) is a secreted protein that inhibits LPL activity and, thereby, triglyceride metabolism, but the impact of Angptl4 on central lipid metabolism is unknown. (harvard.edu)
  • Angiopoietin-like protein 4 (ANGPTL4) is a secreted 50 kD protein that modulates the disposition of circulating triglycerides (TG) by inhibiting lipoprotein lipase (LPL). (biovendor.com)
  • ANGPTL4 was identified as a gene that is induced by fasting, and during 3T3-L1 preadipocyte differentiation, and was thus named HFARP (hepatic fibrinogen/an-giopoietin-related protein), FIAF (fasting-induced adipose factor), and PGAR (PPAR-angiopoietin related). (biovendor.com)
  • Seven angiopoietin-like proteins (ANGPTLs) share the char-acteristic protein structure of the angiopoietin family (ANG), but differ in their inability to bind antiopoietin receptor, Tie-2. (biovendor.com)
  • Angiopoietin-2 (Ang2), a known angiogenic protein, was found to be downregulated by LS both in cultured ECs and mouse aortas. (ahajournals.org)
  • From these and subsequent functional studies, we demonstrate that LS inhibits angiogenesis through the downregulation of Angiopoietin-2 (Ang2), a secreted protein that is required for postnatal angiogenesis. (ahajournals.org)
  • Angiopoietin-like protein 4 (ANGPTL4/FIAF) has been proposed as a circulating mediator between the gut microbiota and fat storage. (biomedsearch.com)
  • Erkan G, Muratoglu S, Ercin U, Bilgihan A. Angiopoietin-like protein 2 and angiopoietin-like protein 6 levels in patients with nonalcoholic fatty liver disease. (termedia.pl)
  • The aim of the current study was to examine the difference between patients detected with nonalcoholic fatty liver disease (NAFLD) and healthy subjects in terms of serum angiopoietin-like protein (ANGPTL) 2 and ANGPTL6 levels and to evaluate the correlation between ANGPTL2 and ANGPTL6 levels and liver enzyme levels, fasting glucose, lipid levels, and steatosis degree on ultrasonography (USG). (termedia.pl)
  • Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. (termedia.pl)
  • Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis. (onmedica.com)
  • Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. (onmedica.com)
  • The present study aimed to determine whether the concentration of angiopoietin-like protein 8 (ANGPTL8), either alone or combined with other risk factors in early pregnancy, could be used to predict subsequent GDM. (springer.com)
  • Angiopoietin-like protein (ANGPTL) 4 inactivates LPL and ANGPTL4 expression is controlled by peroxisome proliferator-activated receptors (PPAR). (diva-portal.org)
  • Angiopoietin-2 (Ang2) is a 75-kDa protein expressed in endothelium that is localized to human chromosomes 8p23.1 and first defined at sites of vascular remodeling [ 5 ]. (jcancer.org)
  • Angiopoietin-like protein 2 (Angptl2) is a mediator of chronic inflammation that contributes to extracellular matrix remodeling. (biomedcentral.com)
  • A 7-day high-PUFA diet reduces angiopoietin-like protein 3 and 8 responses and postprandial triglyceride levels in healthy females but not males: a randomized control trial. (nuthealth.org)
  • Below are the list of possible Angiopoietin-like protein products. (mybiosource.com)
  • Also known as Angiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein). (mybiosource.com)
  • All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. (innov-research.com)
  • We identified the angiopoietin-like protein 4 (ANGPTL4) involved in glomerular endothelial cell (GEC) injury among many induced genes during the course of progressive kidney injury. (nii.ac.jp)
  • Only the levels of angiopoietin-like 4 ( Angptl4 ) mRNA dramatically increased in implantation segments of the uterus during decidualization and was conceptus-independent. (springer.com)
  • Central to this process is the induction of angiopoietin-like 4 (ANGPTL4) by TGFbeta via the Smad signaling pathway. (nih.gov)
  • ANGPTL4, also known as a fasting-induced adipose factor, which is up-regulated by fasting, is one of the seven members of angiopoietin-like proteins (ANGPTLs). (thefreelibrary.com)
  • Angiopoietin-like 4 (ANGPTL4) is neuroprotective when administered acutely for the treatment of cerebral ischemia. (medscimonit.com)
  • Polyunsaturated fatty acids (PUFAs) have beneficial effects on hypertriglyceridemia although their effect on angiopoietin-like proteins (ANGPTLs), specifically ANGPTL3, ANGPTL4 and ANGPTL8 is unknown. (nuthealth.org)
  • Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. (jci.org)
  • 107 Angiopoietin 2 (ANGPT2) Antikörper von 17 Herstellern verfügbar auf www.antikoerper-online.de. (antikoerper-online.de)
  • 171 Angiopoietin 2 (ANGPT2) Antibodies from 26 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
  • Angiopoietin-2 (ANGPT2) has been shown to regulate angiogenesis, but its importance for thrombus resolution and remodelling is unknown. (ersjournals.com)
  • Overexpression of angiopoietin 1 (zeige ANGPT1 ELISA Kits ) and metalloproteinases may be the characteristic feature of endometrium with greater potential to transform into endometriotic lesions in the peritoneal cavity. (antikoerper-online.de)
  • Here, we systematically assessed the expression and function of Angiopoietin-1 ( Angpt1 ) in bone marrow. (elifesciences.org)
  • Angiopoietin-1 antibody LS-C696965 is a Cy3-conjugated rabbit polyclonal antibody to mouse Angiopoietin-1 (ANGPT1). (lsbio.com)
  • Angiopoietin 1, also called ANG1 is a type of angiopoietin and is encoded by the gene ANGPT1. (innov-research.com)
  • TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). (wikipedia.org)
  • In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4). (wikipedia.org)
  • To date, four angiopoietins (Ang1 to 4) bind Tek and behave as either agonists (Ang1 and Ang4) or context-dependent antagonists (Ang2 and Ang3) of Tek kinase activity (Ref. 3). (thermofisher.com)
  • Here, we report that angiopoietin-2 (Ang2), a known growth factor, is capable of promoting breast cancer cell invasion leading to metastasis. (aacrjournals.org)
  • Angiopoietins (Ang1 and Ang2) are ligands for an endothelial cell-specific tyrosine kinase receptor, Tie2, and are important regulators of angiogenesis and tumor progression ( 13 ). (aacrjournals.org)
  • 20) Angiopoietin 2 (Ang2) and vascular EGF (VEGF) inductions correlate remarkably well with this process. (thefreedictionary.com)
  • We carefully examine the regulating mechanisms of vascular endothelial growth factor (VEGF) and angiopoietins (Ang1 and Ang2) on the proliferation, migration and maturation of endothelial cells through their endothelium-specific receptor tyrosine kinase VEGFR2 and Tie2, respectively. (aimsciences.org)
  • Purpose To define proangiogenic angiopoietin 2 (ANG2) expression and role(s) in human and mouse vascularised corneas. (bmj.com)
  • AMG 780 is a mAb that binds to angiopoietin-1 and -2 (Ang1 and Ang2), preventing their binding to the Tie2 receptor to suppress angiogenesis. (aacrjournals.org)
  • The angiopoietin axis is a distinct angiogenic pathway that activates complementary angiogenic processes through binding of the ligands angiopoietin-1 and -2 (Ang1 and Ang2) to the tyrosine kinase receptor Tie2 ( 1 ). (aacrjournals.org)
  • The development and progression of lung cancer is stimulated by angiopoietin-2 (Ang2), a ligand for Tie2, an endothelial tyrosine kinase. (jcancer.org)
  • Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. (wikipedia.org)
  • Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood vessels. (wikipedia.org)
  • Although which specific TIE receptors mediate signals downstream of angiogenesis stimulation is highly contested, it is clear that TIE-2 is capable of activation as a result of binding angiopoietins. (wikipedia.org)
  • The angiopoietin/Tie (ANG/Tie) receptor system controls developmental and tumor angiogenesis, inflammatory vascular remodeling, and vessel leakage. (jci.org)
  • To explore the possibility that VEGFs and angiopoietins collaborate during tumor angiogenesis, we studied early angiogenic events using the rat C6 glioma model ( 17 ). (sciencemag.org)
  • Angiopoietins are proteins with important roles in vascular development and angiogenesis. (antikoerper-online.de)
  • Using an endothelial cell-pericyte coculture system and ex vivo neurite sprouting assay, we found that DKK2-mediated juxtacrine signaling in pericyte-endothelial cell interactions promotes angiogenesis and neural regeneration through an angiopoietin-1-Tie2 pathway, rescuing erectile function in diabetic mice. (diabetesjournals.org)
  • Several proteins have been effective in targeting angiogenesis of the penis in diabetic or hypercholesterolemic animal models of ED, including VE growth factor, angiopoietin (Ang)-1, and Ang4 ( 7 - 14 ). (diabetesjournals.org)
  • Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2 ," Annals of the Rheumatic Diseases, vol. (thefreedictionary.com)
  • Angiopoietin-2 (Ang-2) is involved in angiogenesis in both solid and hematological malignancies. (ovid.com)
  • The findings indicate that the Angiopoietin system may play a role in retinal neovascularisation via the Tie-2 receptor, which may be partially due to an increase in endothelial cells motility, a key step of angiogenesis. (arvojournals.org)
  • The angiopoietin axis plays an important role in angiogenesis and is distinct from currently approved angiogenesis inhibitors which target the VEGF pathway. (aacrjournals.org)
  • Combining nitric oxide (NO)‐mediated increased blood flow with angiopoietin‐1-Tie2 receptor signalling induces arteriolargenesis - the formation of arterioles from capillaries - in a model of physiological angiogenesis. (pubmedcentralcanada.ca)
  • However, its transcriptional regulation is rather moderate compared with other angiogenesis-regulating molecules such as VEGF and Angiopoietin-2 (Ang-2). (biologists.org)
  • Fluorescence energy transfer between Tie1 and Tie2 after angiopoietin stimulation of endothelial cells. (jci.org)
  • Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. (abcam.com)
  • Reducing vascular leakage and stabilizing the endothelium through activation of the angiopoietin (ANGPT)-TIE2 receptor tyrosine kinase pathway is a promising therapeutic strategy for vascular diseases. (pnas.org)
  • Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. (nih.gov)
  • We report the identification of a secreted ligand for TIE2, termed Angiopoietin-1, using a novel expression cloning technique that involves intracellular trapping and detection of the ligand in COS cells. (nih.gov)
  • Although Angiopoietin-1 binds and induces the tyrosine phosphorylation of TIE2, it does not directly promote the growth of cultured endothelial cells. (nih.gov)
  • The angiopoietins are a new family of growth factor ligands that bind specifically to the TIE2/Tek RTK (Receptor Tyrosine Kinase). (thermofisher.com)
  • Angiopoietin-1 can promote migration, sprouting and survival of endothelial cells through activation of different signaling pathways triggered by the Tie2 tyrosine kinase receptor. (thermofisher.com)
  • Angiopoietin 2 and angiopoietin 1 are closely related endothelial cell-specific ligands of the endothelial cellspecific receptor Tie2 expressed on endothelial cells and early hematopoietic cells. (genetex.com)
  • Angiopoietin 2 probably acts as a natural antagonist for Ang1 and Tie2 both in vivo and in vitro. (genetex.com)
  • This article focuses on one such control pathway, the Tie2 receptor and its ligands the angiopoietins, to describe a growing body of genetic, biochemical, mechanistic, and human studies that implicate Tie2 as a critical switch. (asnjournals.org)
  • In sepsis and related diseases, expression of the angiopoietins becomes markedly imbalanced and Tie2 signaling is greatly attenuated. (asnjournals.org)
  • To assess the toxicity, pharmacokinetics, tumor vascular response, tumor response, and pharmacodynamics of AMG 780, a mAb designed to inhibit the interaction between angiopoietin-1 and -2 and the Tie2 receptor. (aacrjournals.org)
  • Signalling through vascular endothelial growth factor (VEGF) receptors and the tyrosine kinase with IgG and EGF domains‐2 (Tie2) receptor by angiopoietins is required in combination with blood flow for the formation of a functional vascular network. (pubmedcentralcanada.ca)
  • Angiopoietins are a family of growth factors that are ligands for the tyrosine kinase receptor, Tie2. (whiterose.ac.uk)
  • Angiopoietin 1 (Ang-1) is agonistic for Tie2, plays a key role in blood vessel maturation and stability and has been shown to possess anti-inflammatory properties. (whiterose.ac.uk)
  • We offer Angiopoietin-2 Antibodies for use in common research applications: ELISA, ELISA Capture (Matched Antibody Pair), ELISA Detection (Matched Antibody Pair), ELISA Standard (Matched Pair), Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot. (novusbio.com)
  • Each Angiopoietin-2 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Choose from our Angiopoietin-2 polyclonal antibodies and browse our Angiopoietin-2 monoclonal antibody catalog. (novusbio.com)
  • This peptide was used for the production of goat polyclonal anti-Angiopoietin-like 4 (mouse) antibody (GTX88798). (genetex.com)
  • Angiopoietin 1 Polyclonal Antibody by Bioss, Cat. (lucerna-chem.ch)
  • RG7716 is the first bispecific, monoclonal antibody specifically designed for the eye that simultaneously binds to and inactivates vascular endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2). (chemdiv.com)
  • For the first time in diabetic macular edema, a clinically meaningful and statistically significant improvement in visual acuity compared to anti-VEGF alone has been demonstrated by simultaneously neutralising both angiopoietin-2 and VEGF-A with a bispecific antibody," said Sandra Horning, MD, Chief Medical Officer and Head of Global Product Development. (chemdiv.com)
  • ANGPTL3 is also known as angiopoietin-like 3, angiopoietin-5 (ANGPT5), ANG-5, and FHBL2. (clontech.com)
  • Our previous study showed that angiopoietin-like 3 (Angptl3) can increase the motility of podocytes in vitro . (hindawi.com)
  • The expression of Angiopoietin-2 in the absence of vascular endothelial growth factor (VEGF) leads to endothelial cell death and vascular regression. (wikipedia.org)
  • The expression patterns of the angiogenic antagonist angiopoietin-2 and of pro-angiogenic vascular endothelial growth factor (VEGF) suggest that these proteins may be critical regulators of this balance between vascular regression and growth. (sciencemag.org)
  • Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) play complementary roles in vascular development during embryogenesis. (sciencemag.org)
  • J. S. Gutkind, Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. (sciencemag.org)
  • These sequential vascular developments are tightly regulated by a range of pro- and anti-angiogenic factors, including VEGF (Vascular Endothelial Growth Factor), bFGF (basic Fibroblast Growth Factor ), Thrombospondin, Angiopoietins and more recently, Angptl (Angiopoietin-like proteins) (Ref. 2). (thermofisher.com)
  • Angiopoietin-1 also acts as an apoptosis survival factor for endothelial cells and this effect is augmented by the presence of VEGF (Kwak et al, 1999). (prospecbio.com)
  • The physiologic roles of Angiopoietin-1 and its receptor are limited to angiogenic processes that occur subsequent to the earlier vasculogenic and angiogenic actions of the VEGF family and their receptors. (prospecbio.com)
  • Most studies have reported vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), and angiopoietin 2 (Ang-2) to be potent regulators of microvascular remodelling in health and atherosclerotic diseases [8]. (thefreedictionary.com)
  • Furthermore, the expression levels of vascular endothelial growth factor (VEGF) and angiopoietin‑2 (Ang‑2) were significantly decreased in HYXZ‑treated groups compared with the model group. (spandidos-publications.com)
  • Vanucizumab is an investigational antiangiogenic, first-in-class, bispecific mAb targeting VEGF-A and angiopoietin-2 (Ang-2). (aacrjournals.org)
  • We demonstrate that a fine balance of VEGF and angiopoietin signalling is required for the formation of a functional vascular network. (pubmedcentralcanada.ca)
  • Endogenous VEGF signalling prevents excess neovessel pericyte coverage, and is required for VSMC recruitment during increased nitric oxide‐mediated vasodilatation and angiopoietin signalling (NO-Tie‐mediated arteriogenesis). (pubmedcentralcanada.ca)
  • Angiopoietin proteins 1 through 4 are all ligands for Tie-2 receptors. (wikipedia.org)
  • The Tie receptors and their angiopoietin (Ang) ligands have important functions during embryonic vessel assembly and maturation and control adult vascular homeostasis. (nature.com)
  • The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr kinase system. (nature.com)
  • Figure 3: Structural properties of the Tie receptors and the Angiopoietin ligands. (nature.com)
  • The structure of Angiopoietin-1 differs from that of known angiogenic factors or other ligands for receptor tyrosine kinases. (nih.gov)
  • Angiopoietins (Angs) are endothelium-selective ligands that exert most of their actions through the Tie-2 receptor. (aspetjournals.org)
  • The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the endothelial receptor tyrosine kinase Tie-2, which controls vascular assembly and endothelial quiescence. (biologists.org)
  • Targeting intracellular Ca 2+ signaling, antagonizing IP 3 with 2-APB or cADPR with 8Br-cADPR, was found to modulate in vitro angiogenic responses to Angiopoietins in a specific way. (hindawi.com)
  • The pro-angiogenic vascular endothelial growth factors (VEGFs) and the angiopoietins are the only known growth factor families that are specific for the vascular endothelium because expression of their receptors is restricted to these cells ( 5 , 6 ). (sciencemag.org)
  • 2. To measure tissue gene expression of the Angiopoietins and other key angiogenic/hypoxic factors in SBA tissue - PCR analysis will be performed to determine gene expression levels of various angiogenic factors in SBA tissue biopsies. (hrb.ie)
  • The angiopoietin-like ( ANGPTL ) genes encode a family of secreted proteins with pleiotropic effects on vascular cells ( 1 ), lipid metabolism ( 2 ), and stem cell biology ( 3 ). (pnas.org)
  • Angiopoietin-like proteins (ANGPTL) 3 and 4 have been shown to inactivate LPL. (sigmaaldrich.com)
  • Structurally, angiopoietins have an N-terminal super clustering domain, a central coiled domain, a linker region, and a C-terminal fibrinogen-related domain responsible for the binding between the ligand and receptor. (wikipedia.org)
  • Angiopoietin-1 is a ligand for the receptor-like tyrosine kinase designated TIE-2 (Davis et al, 1996). (prospecbio.com)
  • Our Angiopoietin-2 Antibodies can be used in a variety of model species: Chicken, Human, Mouse. (novusbio.com)
  • Angiopoietin 2 and angiopoietin 1 have an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain. (genetex.com)
  • ANGPTL6 was originally named angiopoietin-related growth factor (AGF) having an N-terminal coiled-coil-like domain and a C-terminal fibrinogen-like domain, both of which are conserved in ANG. (biovendor.com)
  • The collective interactions between angiopoietins, receptor tyrosine kinases, vascular endothelial growth factors and their receptors form the two signaling pathways- Tie-1 and Tie-2. (wikipedia.org)
  • Angiopoietin-1 and tyrosine kinase signaling are essential for regulating blood vessel development and the stability of mature vessels. (wikipedia.org)
  • citation needed] Angiopoietin#Tie pathway TIE+Receptor+Tyrosine+Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) Jeltsch M, Leppanen VM, Saharinen P, Alitalo K (2013). (wikipedia.org)
  • Binding of Angiopoietin-1 to its receptor induces tyrosine phosphorylation of the cytoplasmic receptor domain. (prospecbio.com)
  • Belanger AJ, Lu H, Date T, Liu LX, Vincent KA, Akita GY, Cheng SH, Gregory RJ, Jiang C (2002) Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1alpha. (springer.com)
  • A naturally occuring antagonist of Angiopoietin-1 binding to TIE-2 is Angiopoietin-2. (prospecbio.com)
  • Angiopoietin-1 also binds to the TIE-1 receptor and this interaction appears to be critical for the development of the right-hand side venous system. (prospecbio.com)
  • When Recombinant Human Tie-2 Fc Chimera (Catalog # 313-TI) is immobilized at 0.5 µg/mL (100 µL/well), Recombinant Human Angiopoietin‑2 (Catalog # 623-AN ) binds with an ED 50 of 0.5-4 ng/mL. (rndsystems.com)
  • Angiopoietin mainly regulates two pathways that mediate cell motility, the first being through activation of the Phosphatidylinositol-3 Kinase pathway and the second involving Ras pathway (Ref. 4). (thermofisher.com)
  • Further, in mice, hemizygosity for Tek led to the formation of severely hypomorphic Schlemm's canal and trabecular meshwork, as well as elevated IOP, demonstrating that anterior chamber vascular development is sensitive to Tek gene dosage and the resulting decrease in angiopoietin-TEK signaling. (duke.edu)
  • We found that all six known murine angiopoietin-like genes were expressed in the mouse uterus during implantation. (springer.com)
  • Kanda, " Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn," Journal of Cell Science, vol. (thefreedictionary.com)
  • Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. (pnas.org)
  • Angiopoietin-1 is a growth factor produced by vascular support cells, specialized pericytes in the kidney, and hepatic stellate cells (ITO) cells in the liver. (wikipedia.org)
  • Recombinant Mouse Angiopoietin-lik. (novusbio.com)
  • Recombinant human angiopoietin 2 has a molecular mass of approximately 66 kDa in SDS-PAGE under reducing and non-reducing conditions. (genetex.com)
  • Purified recombinant human angiopoietin-2 expressed in mouse NSO cells. (genetex.com)
  • 0.2 μg/mL of Recombinant Human Angiopoietin‑2 significantly induces phosphorylation of human Tie-2. (rndsystems.com)
  • The current study addresses this issue, focusing on angiopoietin 2 (Ang-2) and endothelial cell-specific molecule-1 (endocan) in ARDS patients. (thefreedictionary.com)
  • Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis. (termedia.pl)
  • Our Mouse Angiopoietin-1 ELISA Kit is a sandwich ELISA intended for the quantitative determination of mouse Angiopoietin-1 in cell culture supernates, serum and plasma (heparin, EDTA). (innov-research.com)
  • Excess soluble TIE-2 receptors abolish the chemotactic response of endothelial cells toward angiopoietin-1. (prospecbio.com)
  • 4. To measure the response of endothelial cells to alterations in Angiopoietin levels and other hypoxic stimuli - Cell line studies will be performed using HUVECs to determine their response to alterations in levels of Ang-1 and Ang-2 and other factors and hypoxic stimuli. (hrb.ie)
  • The purpose of this work was to determine if and where Angiopoietin-like genes are expressed in the mouse uterus during the implantation period of pregnancy and to determine if uterine expression of such genes is controlled by estrogen or progesterone. (springer.com)
  • However, its expression in close proximity with developing blood vessels implicates Angiopoietin-1 in endothelial developmental processes. (nih.gov)
  • The expression of angiopoietin-1 mRNA is downregulated by PDGF, EGF, IL1-beta, and TGF-beta (Enholm et al, 1997). (prospecbio.com)
  • In hypoxic conditions, expression of hypoxia inducible factoralpha increases rapidly which in turn activates genes that encode for proangiogenic growth factors, such as vascular endothelial growth factor, basic fibroblast growth factor, angiopoietin 1 and angiopoietin 2 , placental growth factor, and platelet-derived growth factor-B [29]. (thefreedictionary.com)
  • CONCLUSION: This is the first report of angiopoietin expression in early inflammatory arthritis. (jrheum.org)
  • Your search returned 59 Angiopoietin-like 7 ELISA ELISA Kit across 6 suppliers. (biocompare.com)
  • Angiopoietin-related growth factor antagonizes obesity and insulin resistance. (nih.gov)
  • We also tested the association of concentration of angiopoietin-2 relative to angiopoietin-1 with physiologic and biological markers of activated endothelium. (biomedsearch.com)
  • Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ. (biomedsearch.com)
  • Angiopoietin cytokines are involved with controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. (wikipedia.org)
  • Previously, we observed PCG-like phenotypes in transgenic mice that lack functional angiopoietin-TEK signaling. (duke.edu)
  • The aim of our study was to evaluate the levels of cytokines (osteopontin and angiopoietins 1 and 2) active in the bone marrow niche during the mobilisation of haematopoietic stem cells for autologous transplantation. (sigmaaldrich.com)
  • Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release," Journal of Vascular Surgery, no. (thefreedictionary.com)
  • Angiopoietin-2 dose-dependently blocks directed migration toward Angiopoietin-1. (prospecbio.com)
  • Intraperitoneal injection of an engineered angiopoietin-1, MAT.Ang-1, induced significant neutrophil migration into the peritoneum and a significant increase in the levels of CCL4 in peritoneal lavage fluid. (whiterose.ac.uk)
  • The angiopoietin receptors are receptors that bind angiopoietin. (wikipedia.org)