AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
AngiopoietinsAngiopoietin-2Angiopoietin-1Receptor, TIE-2Receptor, TIE-1Receptors, TIEVascular Endothelial Growth Factor ANeovascularization, PhysiologicAngiogenesis Inducing AgentsVascular Endothelial Growth FactorsNeovascularization, PathologicEndothelial Growth FactorsReceptor Protein-Tyrosine KinasesLymphokinesMembrane GlycoproteinsIntercellular Signaling Peptides and ProteinsBlood VesselsEndothelial CellsEndothelium, VascularProteinsVascular Endothelial Growth Factor Receptor-1RNA, MessengerReverse Transcriptase Polymerase Chain ReactionImmunohistochemistrySignal TransductionProto-Oncogene ProteinsCells, CulturedBlotting, Western
Angiopoietins
A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.
Angiopoietin-2
An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.
Angiopoietin-1
The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.
Receptor, TIE-2
A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).
Receptor, TIE-1
A TIE receptor found predominantly on ENDOTHELIAL CELLS. It is considered essential for vascular development and can form a heterodimer with the TIE-2 RECEPTOR. The TIE-1 receptor may play a role in regulating BLOOD VESSEL stability and maturation.
Receptors, TIE
A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.
Vascular Endothelial Growth Factor A
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Neovascularization, Physiologic
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
Angiogenesis Inducing Agents
Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.
Vascular Endothelial Growth Factors
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
Neovascularization, Pathologic
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Endothelial Growth Factors
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
Receptor Protein-Tyrosine Kinases
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
Lymphokines
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
Membrane Glycoproteins
Glycoproteins found on the membrane or surface of cells.
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Blood Vessels
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
Endothelial Cells
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Endothelium, Vascular
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Vascular Endothelial Growth Factor Receptor-1
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proto-Oncogene Proteins
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Blotting, Western
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (1/298)

Using homology-based PCR, we have isolated cDNA encoding a novel member (491 amino acids) of the angiopoietin (Ang) family from human adult heart cDNA and have designated it angiopoietin-3 (Ang3). The NH2-terminal and COOH-terminal portions of Ang-3 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in other known Angs. Ang3 has a highly hydrophobic region at the N-terminus (approximately 21 amino acids) that is typical of a signal sequence for protein secretion. Ang3 mRNA is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine in human adult tissues. Additionally, Ang3 is a secretory protein, but is not a mitogen in endothelial cells.  (+info)

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (2/298)

The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist, angiopoietin-2, both of which act by means of the Tie2 receptor. We now report our attempts to use homology-based cloning approaches to identify new members of the angiopoietin family. These efforts have led to the identification of two new angiopoietins, angiopoietin-3 in mouse and angiopoietin-4 in human; we have also identified several more distantly related sequences that do not seem to be true angiopoietins, in that they do not bind to the Tie receptors. Although angiopoietin-3 and angiopoietin-4 are strikingly more structurally diverged from each other than are the mouse and human versions of angiopoietin-1 and angiopoietin-2, they appear to represent the mouse and human counterparts of the same gene locus, as revealed in our chromosomal localization studies of all of the angiopoietins in mouse and human. The structural divergence of angiopoietin-3 and angiopoietin-4 appears to underlie diverging functions of these counterparts. Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist.  (+info)

Angiopoietin-3, a novel member of the angiopoietin family. (3/298)

A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2.  (+info)

Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. (4/298)

Using degenerate polymerase chain reaction, we isolated a cDNA encoding a novel 493-amino acid protein from human and mouse adult heart cDNAs and have designated it angiopoietin-related protein-2 (ARP2). The NH(2)-terminal and COOH-terminal portions of ARP2 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in angiopoietins. ARP2 has two consensus glycosylation sites and a highly hydrophobic region at the NH(2) terminus that is typical of a secretory signal sequence. Recombinant ARP2 expressed in COS cells is secreted and glycosylated. In human adult tissues, ARP2 mRNA is most abundant in heart, small intestine, spleen, and stomach. In rat embryos, ARP2 mRNA is most abundant in the blood vessels and skeletal muscles. Endothelial and vascular smooth muscle cells also contain ARP2 mRNA. Recombinant ARP2 protein induces sprouting in vascular endothelial cells but does not bind to the Tie1 or Tie2 receptor. These results suggest that ARP2 may exert a function on endothelial cells through autocrine or paracrine action.  (+info)

Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (5/298)

Using degenerate PCR we isolated a cDNA encoding a novel 406- and 410-amino acid protein from human and mouse embryonic cDNAs and have designated it 'hepatic fibrinogen/angiopoietin-related protein' (HFARP). The N-terminal and C-terminal portions of HFARP contain the characteristic coiled-coil domains and fibrinogen-like domains that are conserved in angiopoietins. In human and mouse tissues, HFARP mRNA is specifically expressed in the liver. HFARP mRNA and protein are mainly present in the hepatocytes. HFARP has a highly hydrophobic region at the N-terminus that is typical of a secretory signal sequence and one consensus glycosylation site. Recombinant HFARP expressed in COS-7 cells is secreted and glycosylated. HFARP protein is present not only in the hepatocytes, but also in the circulating blood. Recombinant HFARP acts as an apoptosis survival factor for vascular endothelial cells, but does not bind to Tie1 or Tie2 (endothelial-cell tyrosine kinase receptors). These results suggest that HFARP may exert a protective function on endothelial cells through an endocrine action.  (+info)

Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. (6/298)

The angiopoietins are recently described growth factors for vascular endothelium. The Tie1 and Tie2 receptors are expressed by endothelium. Acquired immune deficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS) and cutaneous angiosarcoma are malignancies of endothelial origin. KS involves primarily the skin and mucosal surfaces and is common in AIDS patients. In an effort to determine whether the angiopoietins and Tie receptors play a role in the pathobiology of angiosarcoma and KS, we studied the expression of angiopoietin-1, angiopoietin-2, angiopoietin-4, Tie1, and Tie2 mRNAs in biopsies of KS from 12 AIDS patients, in biopsies of cutaneous angiosarcoma from two patients, and in control biopsies of normal skin from three volunteers by in situ hybridization. Strong expression of angiopoietin-2, Tie1, and Tie2 mRNAs was detected in the tumor cells of KS and cutaneous angiosarcomas, in contrast to the focal low-level expression in normal skin biopsies. Focal low-level expression of angiopoietin-1 was seen in KS, cutaneous angiosarcomas, and in normal skin. Focal low-level expression of angiopoietin-4 was identified in a minority of KS lesions. These findings suggest that the angiopoietins and Tie receptors may play an important role in the pathobiology of KS and cutaneous angiosarcoma and identify additional potential targets for therapeutic intervention in these vascular malignancies.  (+info)

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. (7/298)

Fasting is associated with significant changes in nutrient metabolism, many of which are governed by transcription factors that regulate the expression of rate-limiting enzymes. One factor that plays an important role in the metabolic response to fasting is the peroxisome proliferator-activated receptor alpha (PPARalpha). To gain more insight into the role of PPARalpha during fasting, and into the regulation of metabolism during fasting in general, a search for unknown PPARalpha target genes was performed. Using subtractive hybridization (SABRE) comparing liver mRNA from wild-type and PPARalpha null mice, we isolated a novel PPARalpha target gene, encoding the secreted protein FIAF (for fasting induced adipose factor), that belongs to the family of fibrinogen/angiopoietin-like proteins. FIAF is predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. Moreover, FIAF mRNA is decreased in white adipose tissue of PPARgamma +/- mice. FIAF protein can be detected in various tissues and in blood plasma, suggesting that FIAF has an endocrine function. Its plasma abundance is increased by fasting and decreased by chronic high fat feeding. The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions.  (+info)

Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (8/298)

The nuclear receptor peroxisome proliferator-activated receptor gamma regulates adipose differentiation and systemic insulin signaling via ligand-dependent transcriptional activation of target genes. However, the identities of the biologically relevant target genes are largely unknown. Here we describe the isolation and characterization of a novel target gene induced by PPARgamma ligands, termed PGAR (for PPARgamma angiopoietin related), which encodes a novel member of the angiopoietin family of secreted proteins. The transcriptional induction of PGAR follows a rapid time course typical of immediate-early genes and occurs in the absence of protein synthesis. The expression of PGAR is predominantly localized to adipose tissues and placenta and is consistently elevated in genetic models of obesity. Hormone-dependent adipocyte differentiation coincides with a dramatic early induction of the PGAR transcript. Alterations in nutrition and leptin administration are found to modulate the PGAR expression in vivo. Taken together, these data suggest a possible role for PGAR in the regulation of systemic lipid metabolism or glucose homeostasis.  (+info)

Angiopoietin-like Protein 1/ANGPTL1 Proteins: Novus BiologicalsAngiopoietin-like Protein 1/ANGPTL1 Proteins: Novus Biologicals
Angiopoietin-like Protein 1/ANGPTL1 Proteins available through Novus Biologicals. Browse our Angiopoietin-like Protein 1/ANGPTL1 Protein catalog backed by our Guarantee+.
https://www.novusbio.com/proteins/angiopoietin-like-protein-1-angptl1
Recombinant Human Angiopoietin-like Protein 6 [PRP-832CYT]Recombinant Human Angiopoietin-like Protein 6 [PRP-832CYT]
Synonyms: Angiopoietin-Like Protein 6, Angiopoietin-Related Protein 5, Angiopoietin-Related Growth Factor, Angiopoietin-Related Protein 6, AGF, ARP5.. ...
https://atsbio.com/products/prp832cyt/
Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria | Lipids in Health and Disease | Full...Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria | Lipids in Health and Disease | Full...
Angiopoietin-like protein 3(ANGPTL3) is well acknowledged as a key regulator of lipid metabolism. Now, there have not been enough data to explain the mechanism of hyperlipidemia related proteinuria. In this study, we hoped to investigate the changes of Angiopoietin-like protein 3(ANGPTL3) levels in hyperlipidemia patients with different proteinuria levels. Seventy-one patients with hyperlipidemia were selected, who were hospitalized in Gansu Provincial Peoples Hospital from September 2016 to September 2017, and 20 healthy people in the physical examination center were selected. We combed through medical history and conducted clinical biochemical indicators of blood urea nitrogen (BUN), serum creatinine (SCr), 24 h urine protein quantitation (24hUPro), cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low detection of density lipoproteins (LDL-C). The concentration of serum ANGPTL3 was measured by ELISA. 1. Serum ANGPTL3 in patients with hyperlipidemia related proteinuria was
https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1052-1
Angiopoietin-like protein elisa and antibodyAngiopoietin-like protein elisa and antibody
Shop Angiopoietin-like protein ELISA Kit, Recombinant Protein and Angiopoietin-like protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=angiopoietin-like-protein
Angiopoietin-related protein 2 - WikipediaAngiopoietin-related protein 2 - Wikipedia
Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene. Angiopoietin-like protein 2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas an excess of ANGPTL2 activation induced by prolonged stress promotes the breakdown of tissue homeostasis due to chronic inflammation, promoting the development of metabolic diseases. ANGPTL2 has a role also in angiogenesis, in tissue repair, in obesity, in atherosclerotic diseases and finally in cancerogenesis. Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. GRCh38: ...
https://en.wikipedia.org/wiki/Angiopoietin-related_protein_2
Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4...Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4...
Lipoprotein lipase (LPL) hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue. LPL in macrophages in the artery wall may, however, promote foam cell formation and atherosclerosis. Angiopoietin-like protein (ANGPTL) 4 inactivates LPL and ANGPTL4 expression is controlled by peroxisome proliferator-activated receptors (PPAR). The mechanisms for inactivation of LPL by ANGPTL4 was studied in THP-1 macrophages where active LPL is associated with cell surfaces in a heparin-releasable form, while LPL in the culture medium is mostly inactive. The PPAR delta agonist GW501516 had no effect on LPL mRNA, but increased ANGPTL4 mRNA and caused a marked reduction of the heparin-releasable LPL activity concomitantly with accumulation of inactive, monomeric LPL in the medium. Intracellular ANGPTL4 was monomeric, while dimers and tetramers of ANGPTL4 were present in the heparin-releasable fraction and medium. GW501516 caused an increase ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:559139
Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: A brown adipose tissue-derived endocrine factor with a potential role in...
Our products have been quoted by publications of Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: A brown adipose tissue-derived endocrine factor with a potential role in fetal growth from Translational Research.
http://eiaab.com/paper/723
Angiopoietin-like protein 2 (ANGPTL2) induces expressio | Open-iAngiopoietin-like protein 2 (ANGPTL2) induces expressio | Open-i
Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA expression of the anti-apoptotic BCL-2 family
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4317964_cas0105-1550-f2&req=4
Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via...Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via...
Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin β1 signaling in human hepatocellular ...
http://onlinelibrary.wiley.com/doi/10.1002/hep.24669/abstract?globalMessage=0
Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell...
TY - JOUR. T1 - Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. AU - Kim, Injune. AU - Kim, Hwan Gyu. AU - Kim, Hyun. AU - Kim, Hong Hee. AU - Park, Sung Kwang. AU - Uhm, Chang Sub. AU - Lee, Zang Hee. AU - Koh, Gou Young. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 2000/3/15. Y1 - 2000/3/15. N2 - Using degenerate PCR we isolated a cDNA encoding a novel 406- and 410-amino acid protein from human and mouse embryonic cDNAs and have designated it hepatic fibrinogen/angiopoietin-related protein (HFARP). The N-terminal and C-terminal portions of HFARP contain the characteristic coiled-coil domains and fibrinogen-like domains that are conserved in angiopoietins. In human and mouse tissues, HFARP mRNA is specifically expressed in the liver. HFARP mRNA and protein are mainly present in the hepatocytes. HFARP has a highly hydrophobic region at the N-terminus that is typical of a ...
https://koreauniv.pure.elsevier.com/en/publications/hepatic-expression-synthesis-and-secretion-of-a-novel-fibrinogena
Angiopoietin-Related Protein 4 | Semantic ScholarAngiopoietin-Related Protein 4 | Semantic Scholar
Angiopoietin-related protein 4 (406 aa, ~45 kDa) is encoded by the human ANGPTL4 gene. This protein plays a role in the modulation of signaling during hypoxic stress and angiogenesis.
https://www.semanticscholar.org/topic/Angiopoietin-Related-Protein-4/1290191
Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis | CirculationAbstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis | Circulation
Chronic vascular inflammation in coronary artery plays crucial roles in pathogenesis of coronary artery disease (CAD) through causing endothelial dysfunction and the progression of coronary atherosclerosis. Recently, we reported that adipose tissue-derived Angptl2 is a key mediator linking obesity to adipose tissue inflammation and systemic insulin resistance (Cell Metabolism 2009). Since angptl2 is also secreted from endothelial cells, and promotes vascular inflammation via the integrin α5β1/Rac1/NF-κB pathway, we investigated whether Angptl2 cause the coronary endothelial dysfunction and atherosclerosis in CAD. First, we compared circulating Angptl2 levels in 83 subjects with coronary endothelial dysfunction (CED) and 30 subjects with chest pain syndrome (CPS) of normal coronary endothelial function. We assessed coronary endothelial function by estimating the ratio of coronary blood flow in response to intracoronary injection of acetylcholine (ACh). Plasma Angptl2 concentrations were ...
http://circ.ahajournals.org/content/122/Suppl_21/A11343
Angiopoietin-like Protein 5/ANGPTL5 Antibody (H00253935-D01P): Novus BiologicalsAngiopoietin-like Protein 5/ANGPTL5 Antibody (H00253935-D01P): Novus Biologicals
Rabbit Polyclonal Anti-Angiopoietin-like Protein 5/ANGPTL5 Antibody. Validated: WB, ELISA. Tested Reactivity: Human. 100% Guaranteed.
https://www.novusbio.com/products/angiopoietin-like-protein-5-angptl5-antibody_h00253935-d01p
KAKEN - Research Projects | The role of angiopoietin-like protein 4 (ANGPTL4) in the glomerular endothelial cell injury and...KAKEN - Research Projects | The role of angiopoietin-like protein 4 (ANGPTL4) in the glomerular endothelial cell injury and...
Principal Investigator：KAGAMI Shoji, Project Period (FY)：2011 - 2013, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Pediatrics
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23591570/
Angiopoietin-Like Protein 4 - from Sheep - for ELISA - Antigene from HEK293 - Antibodies | BioVendor Research and Diagnostics...Angiopoietin-Like Protein 4 - from Sheep - for ELISA - Antigene from HEK293 - Antibodies | BioVendor Research and Diagnostics...
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
https://www.biovendor.com/antibodies?molecule=Angiopoietin-Like+Protein+4&host=Sheep&application=ELISA&sourceOfAntigen=HEK293
Angiopoietin-Like Protein 4 - Polyclonal Antibody - from Rabbit - Antigene from E. coli - Antibodies | BioVendor Research and...Angiopoietin-Like Protein 4 - Polyclonal Antibody - from Rabbit - Antigene from E. coli - Antibodies | BioVendor Research and...
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
https://www.biovendor.com/antibodies?molecule=Angiopoietin-Like%20Protein%204&type=Polyclonal%20Antibody&host=Rabbit&sourceofantigen=E.%20coli
Response of angiopoietin-like proteins 3 and 4 to hemodialysis. | Sigma-AldrichResponse of angiopoietin-like proteins 3 and 4 to hemodialysis. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Dana Mahmood, Elena Makoveichuk, Solveig Nilsson, Gunilla Olivecrona, Bernd Stegmayr].
https://www.sigmaaldrich.com/catalog/papers/24634330
The direct peroxisome proliferator-activated receptor target fasting-induced adi :: TNO RepositoryThe direct peroxisome proliferator-activated receptor target fasting-induced adi :: TNO Repository
The fasting-induced adipose factor (FIAF, ANGPTL4, PGAR, HFARP) was previously identified as a novel adipocytokine that was up-regulated by fasting, by peroxisome proliferator-activated receptor agonists, and by hypoxia. To further characterize FIAF, we studied regulation of FIAF mRNA and protein in liver and adipose cell lines as well as in human and mouse plasma. Expression of FIAF mRNA was up-regulated by peroxisome proliferator-activated receptor α (PPARα) and PPARβ/δ agonists in rat and human hepatoma cell lines and by PPARγ and PPARβ/δ agonists in mouse and human adipocytes. Transactivation, chromatin immunoprecipitation, and gel shift experiments identified a functional PPAR response element within intron 3 of the FIAF gene. At the protein level, in human and mouse blood plasma, FIAF was found to be present both as the native protein and in a truncated form. Differentiation of mouse 3T3-L1 adipocytes was associated with the production of truncated FIAF, whereas in human white ...
https://repository.tudelft.nl/view/tno/uuid%3Aa51926c2-8ba3-4a49-b2da-8786395c9744
Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise<...
TY - JOUR. T1 - Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise. AU - Abu-Farha, Mohamed. AU - Cherian, Preethi. AU - Al khairi, Irina. AU - Madhu, Dhanya. AU - Tiss, Ali. AU - Warsam, Samia. AU - Alhubail, Asma. AU - Sriraman, Devarajan. AU - Al-Refaei, Faisal. AU - Abubaker, Jehad. PY - 2017/3/1. Y1 - 2017/3/1. N2 - Objective ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. The biological role of ANGPTL7 is yet to be understood except for a recently proposed role in the pathophysiology of glaucoma. This study was designed to shed light on the function of ANGPTL7 in obesity and its modulation by physical exercise as well as its potential association with lipid profile. Methods A total of 144 subjects were enrolled in this study and finished three months of physical ...
https://research.dasmaninstitute.org/en/publications/plasma-and-adipose-tissue-level-of-angiopoietin-like-7-angptl7-ar-2
A Polyglucuronic Acid to Target the FIAF Adipokine for Slimming EffectsA Polyglucuronic Acid to Target the FIAF Adipokine for Slimming Effects
Effective slimming actives should reduce lipogenesis, increase lipolysis, promote fatty acid release and improve skin firmness. Here, the authors describe the development of such an active based on polyglucuronic acid. Further, this material is shown to act on a new biological pathway involving the fasting-induced adipose factor (FIAF) adipokine.
http://www.cosmeticsandtoiletries.com/formulating/function/active/premium-A-Polyglucuronic-Acid-to-Target-the-FIAF-Adipokine-for-Slimming-Effects-211022481.html
The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy...The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy...
Author(s): McQueen, Allison E; Kanamaluru, Deepthi; Yan, Kimberly; Gray, Nora E; Wu, Leslie; Li, Mei-Lan; Chang, Anthony; Hasan, Adeeba; Stifler, Daniel; Koliwad, Suneil K; Wang, Jen-Chywan | Abstract: Angptl4 (Angiopoietin-like 4) is a circulating protein secreted by white and brown adipose tissues and the liver. Structurally, Angptl4 contains an N-terminal coiled-coil domain (CCD) connected to a C-terminal fibrinogen-like domain (FLD) via a cleavable linker, and both full-length Angptl4 and its individual domains circulate in the bloodstream. Angptl4 inhibits extracellular lipoprotein lipase (LPL) activity and stimulates the lipolysis of triacylglycerol stored by adipocytes in the white adipose tissue (WAT). The former activity is furnished by the CCD, but the Angptl4 domain responsible for stimulating adipocyte lipolysis is unknown. We show here that the purified FLD of Angptl4 is sufficient to stimulate lipolysis in mouse primary adipocytes and that increasing circulating FLD levels in mice through
https://escholarship.org/uc/item/43p8g22j
Angiopoietin-related growth factor antagonizes obesity and insulin resistance. - PubMed - NCBIAngiopoietin-related growth factor antagonizes obesity and insulin resistance. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/15778720?dopt=Abstract
Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its...
Angiopoietin-like 4 (ANGPTL4) is involved in angiogenesis and lipid metabolism. It is secreted by liver and adipose tissues and cleaved to generate circulating coiled-coil domain (CCD) and fibrinogen-like domain (FLD) fragments. The full-length ANGPTL4 produced by hypoxic endothelial cells interacts with the extracellular matrix (ECM). The ECM-bound and soluble forms of ANGPTL4 have antiangiogenic properties. We carried out a structure-function analysis to investigate the regulation of ANGPTL4 bioactivity in endothelial cells. We found that the recombinant CCD binds to the ECM, whereas the FLD is released into the medium. The CCD, like the full-length ANGPTL4, binds to heparan and dermatan sulfates in surface plasmon resonance assays and inhibits endothelial cell adhesion, motility, and tubule-like formation. In endothelial cells, ANGPTL4 is processed in the secretion medium after release from the ECM. This processing is altered by the proprotein convertases inhibitor alpha1-PDX and abolished by the
https://www.hal.inserm.fr/inserm-00341205
Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activityDifferential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity
Objective: Lipoprotein lipase (LPL) is a key regulator of circulating triglyceride rich lipoprotein hydrolysis. In brain LPL regulates appetite and energy expenditure. Angiopoietin-like 4 (Angptl4) is a secreted protein that inhibits LPL activity and, thereby, triglyceride metabolism, but the impact of Angptl4 on central lipid metabolism is unknown. Methods: We induced type 1 diabetes by streptozotocin (STZ) in whole-body Angptl4 knockout mice (Angptl4-/-) and their wildtype littermates to study the role of Angptl4 in central lipid metabolism. Results: In type 1 (streptozotocin, STZ) and type 2 (ob/ob) diabetic mice, there is a ~2-fold increase of Angptl4 in the hypothalamus and skeletal muscle. Intracerebroventricular insulin injection into STZ mice at levels which have no effect on plasma glucose restores Angptl4 expression in hypothalamus. Isolation of cells from the brain reveals that Angptl4 is produced in glia, whereas LPL is present in both glia and neurons. Consistent with the in vivo ...
https://dash.harvard.edu/handle/1/14065548
TNO Repository search for: creator:Tan, N.S.TNO Repository search for: creator:Tan, N.S.
Objective: Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development. Approach and Results: Macrophage activation elicited by pathogen-recognition receptor agonists decreased Angptl4 expression, whereas lipid loading by intralipid and oxidized low-density lipoprotein increased Angptl4 expression. Consistent with an antilipotoxic role of Angptl4, recombinant Angptl4 significantly decreased uptake of oxidized low-density lipoprotein by macrophages, via lipolysis-dependent and -independent mechanisms. Angptl4 protein was detectable in human atherosclerotic lesions and localized to macrophages. Transgenic overexpression of Angptl4 in atherosclerosis-prone ...
https://repository.tudelft.nl/search/tno/?q=creator%3A%22Tan%2C%20N.S.%22
Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage ...Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage ...
BACKGROUND:Angiopoietin-like 4 (ANGPTL4) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to evaluate the preventive effects of ANGPTL4 on the formation of brain edema and to determine whether it promotes the recovery of neurological function following intracerebral hemorrhage (ICH). MATERIAL AND METHODS:Recombinant human ANGPTL4 (rhANGPTL4; 40 µg/kg) or a vehicle was administered intraperitoneally 5 min prior to bacterial collagenase-induced ICH in male C57/B6J mice. Behavioral tests were performed prior to ICH and at days 1, 3, 7, 14, 21, and 28 after ICH. Brain edema and hematoma volume were examined separately using the wet weight/dry weight method and hematoxylin-eosin staining. The integrity of the tight and adherens junctions was quantified via immunofluorescence. The ultrastructure of the blood-brain barrier (BBB) was examined using transmission electron microscopy. Vascular endothelial (VE)-cadherin, claudin-5, Src, and
https://www.medscimonit.com/abstract/index/idArt/907939
ANGPTL4 Human Recombinant Protein - Cytokines - Recombinant Protein - Full-Length Protein - Products | ProMabANGPTL4 Human Recombinant Protein - Cytokines - Recombinant Protein - Full-Length Protein - Products | ProMab
The ANGPTL4 Human Recombinant is manufactured with C-terminal fusion of 11 amino acid FLAG Tag. The ANGPTL4 Flag -Tagged Fusion Protein is a 44.2kDa protein containing 392 amino acid residues of the Angiopoietin-like Protein 4 and 11 additional amin
https://www.promab.com/products/full-length-proteins/recombinant-protein-full/cytokines/angptl4-human-recombinant-protein-pr20086
Model of tumor cell resistance to antineoplastic therap | Open-iModel of tumor cell resistance to antineoplastic therap | Open-i
Model of tumor cell resistance to antineoplastic therapy through angiopoietin-like protein 2 (ANGPTL2) expression. Tumor cell-secreted ANGPTL2 induces spleen ty
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4317964_cas0105-1550-f7&req=4
JCI Insight - E-lettersJCI Insight - E-letters
The angiopoietin-like protein ANGPTL8 (A8) is one of three ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is expressed in liver and adipose tissue, is required to redirect dietary TG from oxidative to storage tissues following food intake. Here we show that A8 from liver and adipose tissue have different roles in this process. Mice lacking hepatic A8 have no circulating A8, high intravascular LPL activity, low plasma TG levels, and evidence of decreased delivery of dietary lipids to adipose tissue. In contrast, mice lacking A8 in adipose tissue have higher postprandial TG levels and no alteration in fatty acid composition in adipocytes. Expression of A8, together with A4, in cultured cells reduced A4 secretion and A4-mediated LPL inhibition. Thus, hepatic A8 (with A3) acts in an endocrine fashion to inhibit intravascular LPL in oxidative tissues, ...
https://insight.jci.org/eletters/submit/138777
The gut microbiota as an environmental factor that regulates fat storage | PNASThe gut microbiota as an environmental factor that regulates fat storage | PNAS
LPL is a key regulator of fatty acid release from triglyceride-rich lipoproteins in muscle, heart, and fat (22). Increased adipocyte LPL activity leads to increased cellular uptake of fatty acids and adipocyte triglyceride accumulation. In white fat, LPL is regulated posttranscriptionally by nutritional status: fasting reduces and refeeding increases enzyme activity (23). Intriguingly, we found that a 14-d conventionalization increased LPL activity 122% in epididymal fat pads (Fig. 4C ). Moreover, the effect was not confined to fat: enzymatic assays of heart revealed a 99% increase with conventionalization (Fig. 4C ). Increased insulin levels produce reductions in muscle LPL activity (24). Therefore, our findings indicated that the microbiota induces the observed general increase in LPL through another mechanism.. Fiaf, also known as angiopoietin-like protein 4, is produced by brown and white fat, liver, and intestine (13, 25, 26). This secreted protein is an inhibitor of LPL in vitro [IC50 = ...
https://www.pnas.org/content/101/44/15718?ijkey=94009022e49cd6266e438ecfeed54449e397615b&keytype2=tf_ipsecsha
Search Results | Clinical Science | Portland PressSearch Results | Clinical Science | Portland Press
Chronic exposure of pancreatic β-cells to saturated non-esterified fatty acids can lead to inhibition of insulin secretion and apoptosis. Several previous studies have demonstrated that saturated fatty acids such as PA (palmitic acid) are detrimental to β-cell function compared with unsaturated fatty acids. In the present study, we describe the effect of the polyunsaturated AA (arachidonic acid) on the function of the clonal pancreatic β-cell line BRIN-BD11 and demonstrate AA-dependent attenuation of PA effects. When added to β-cell incubations at 100 μM, AA can stimulate cell proliferation and chronic (24 h) basal insulin secretion. Microarray analysis and/or real-time PCR indicated significant AA-dependent up-regulation of genes involved in proliferation and fatty acid metabolism [e.g. Angptl (angiopoietin-like protein 4), Ech1 (peroxisomal Δ 3,5 ,Δ 2,4 -dienoyl-CoA isomerase), Cox-1 (cyclo-oxygenase-1) and Cox-2 , P ,0.05]. Experiments using specific COX and LOX (lipoxygenase) ...
https://portlandpress.com/clinsci/search-results?f_Authors=Shalinee+Dhayal
Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change DiseaseAngiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease
Podocyte injury plays central roles in proteinuria and kidney dysfunction, therefore, identifying specific biomarker to evaluate earlier podocyte injury is highly desirable. Podocyte-secreted angiopoietin-like-4 (Angptl4) mediates proteinuria in different types of podocytopathy. In the present study …
https://pubmed.ncbi.nlm.nih.gov/26352670/?dopt=Abstract
JCI - Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edemaJCI - Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema
The majority of patients with diabetic macular edema (DME), the most common cause of vision loss in working-age Americans, do not respond adequately to current therapies targeting VEGFA. Here, we show that expression of angiopoietin-like 4 (ANGPTL4), a HIF-1-regulated gene product, is increased in the eyes of diabetic mice and patients with DME. We observed that ANGPTL4 and VEGF act synergistically to destabilize the retinal vascular barrier. Interestingly, while ANGPTL4 modestly enhanced tyrosine phosphorylation of VEGF receptor 2, promotion of vascular permeability by ANGPTL4 was independent of this receptor. Instead, we found that ANGPTL4 binds directly to neuropilin 1 (NRP1) and NRP2 on endothelial cells (ECs), leading to rapid activation of the RhoA/ROCK signaling pathway and breakdown of EC-EC junctions. Treatment with a soluble fragment of NRP1 (sNRP1) prevented ANGPTL4 from binding to NRP1 and blocked ANGPTL4-induced activation of RhoA as well as EC permeability in vitro and retinal ...
https://www.jci.org/articles/view/120879/figure/8
lipid migration
Previously, I discussed how important gut microbiota is in disease condition and how it may contribute to TLR4 signaling pathway. In todays post, I will discuss how gut microbiome can affect lipid metabolism.. Several studies supported a role for gut microbiota in the modulation of lipid metabolism1-3. In one of the early studies on this topic, Jeffrey Gordon group were able to show that conventialization of adult GF C57BL/6 mice with a normal microbiota resulted in a 60% increase in body fat content despite reduced food intake2. Further, they were able to demonstrate that Fasting-induced adipocyte factor (Fiaf) - also known as Angiopoietin-like 4 (ANGPTL4), a member of angiopoietin-like family of proteins, is suppressed in the intestine of normal mice after conventialization2. Their data from fiaf -/- mice also revealed that Fiaf is a LPL inhibitor and its suppression is needed for gut microbiota-induced deposition of triglyceride in adipose tissue. Continuing to further support the merging ...
https://earlycareervoice.professional.heart.org/tag/lipid-migration/
Applications filed at Dec 14 2017 | ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF | Patents.comApplications filed at Dec 14 2017 | ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF | Patents.com
MODULATION OF ALTERNATIVE MDM2 SPLICING | FACTOR V/Va-TARGETING APTAMER COMPOSITONS AND METHODS OF USING THE SAME | COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS | TREATMENT OF SODIUM CHANNEL, VOLTAGE-GATED, ALPHA SUBUNIT (SCNA) RELATED DISEASES BY INHIBITION OF NATURAL... | RNAI INDUCED HUNTINGTIN GENE SUPPRESSION |
http://www.patents.com/ap-20171214-p79.html
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
Cells released from primary tumors seed metastases to specific organs by a nonrandom process, implying the involvement of biologically selective mechanisms. Based on clinical, functional, and molecular evidence, we show that the cytokine TGFbeta in the breast tumor microenvironment primes cancer cel …
https://pubmed.ncbi.nlm.nih.gov/18394990/?dopt=Abstract
Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic...Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/24903577?dopt=Abstract
OriGene - ANGPTL4 (NM 001039667) Human ORF cDNA CloneOriGene - ANGPTL4 (NM 001039667) Human ORF cDNA Clone
ANGPTL4 - ANGPTL4 (Myc-DDK-tagged)-Human angiopoietin-like 4 (ANGPTL4), transcript variant 3 available for purchase from OriGene - Your Gene Company.
http://www.origene.com/orf_clone/trueclone/NM_001039667/RC224424/ANGPTL4.aspx
OriGene - Angptl4 (NM 199115) Human ORF cDNA CloneOriGene - Angptl4 (NM 199115) Human ORF cDNA Clone
Angptl4 - Angptl4 (Myc-DDK-tagged ORF) - Rat angiopoietin-like 4 (Angptl4), (10 ug) available for purchase from OriGene - Your Gene Company.
http://www.origene.com/Rat_ORF/RR211040.aspx
Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin...Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin...
The aim of the present study was to examine the association of angiopoietin-like proteins-8 (ANGPTL8) rs2278426, cholesteryl ester-transfer protein (CETP) rs708272 and endothelial nitric oxide synthase (NOS3) rs1799983 variants with type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), and to investigate the effect of the potential interaction between these variants on disease risk. Our study included 272 subjects classified into 68 patients with T2DM, 68 patients with T2DM complicated with CVD and 136 control subjects. ANGPTL8 c194C|T, CETP Taq1B and NOS3 G894T polymorphisms were genotyped using TaqMan® SNP Genotyping Assay. The presence of NOS3, ANGPTL8, and homozygous CETP B1 variants were associated with increased risk of T2DM by 3.07-, 2.33- and 1.75-fold, respectively. NOS3 variant was associated with 3.08-fold increased risk of CVD (95% CI 1.70-5.60), while ANGPTL8 C allele was associated with 2.8-fold increased risk of CVD in T2DM patients (95% CI 1.13-6.97). Concomitant presence of
https://cardiab.biomedcentral.com/articles/10.1186/s12933-018-0742-8
Most recent papers with the keyword Fatty Acid Metabolism Suberate | Read by QxMDMost recent papers with the keyword Fatty Acid Metabolism Suberate | Read by QxMD
The angiopoietin-like 4 (ANGPLT4) protein is involved in lipid metabolism and is known to inhibit lipoprotein lipase in the bloodstream. We investigated the effect of milk on intestinal ANGPTL4 and the metabolic profile of growing pigs and the effect of free fatty acids (FFAs) on ANGPTL4 in ex vivo and in vitro assays. Feeding pigs whole milk increased intestinal ANGPTL4 mRNA and increased fecal excretion of long-chain FFA compared to the control group fed soybean oil (n = 9). Furthermore, FFAs (C4-C8) induced ANGPTL4 gene expression in porcine intestinal tissue mounted in Ussing chambers and ANGPTL4 protein secretion to both the apical and basolateral sides of intestinal Caco-2 cells on permeable membranes ...
https://www.readbyqxmd.com/keyword/68100
ANGPTL3 purified MaxPab rabbit polyclonal antibody (D01P) - (H00027329-D01P) - Products - Abnova
Rabbit polyclonal antibody raised against a full-length human ANGPTL3 protein. ANGPTL3 (NP_055310.1, 1 a.a. ~ 460 a.a) full-length human protein. (H00027329-D01P) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=H00027329-D01P
Second blood-vessel-growth protein implicated in PDR | OphthalmologyTimesSecond blood-vessel-growth protein implicated in PDR | OphthalmologyTimes
Targeting the blood-vessel-growth protein angiopoietin-like 4 (ANGPTL4) along with anti-vascular endothelial growth factor (VEGF) therapy could increase the effectiveness of treatments for the prevention of proliferative diabetic retinopathy (PDR), according to researchers at The Johns Hopkins University and the University of Maryland.
http://ophthalmologytimes.modernmedicine.com/ophthalmologytimes/news/second-blood-vessel-growth-protein-implicated-pdr?page=0,1
Germain - CIRB - Collège de France
We are using a multidisciplinary approach combining gene discovery approach for complex human diseases, vascular cell biology (endothelial and smooth muscle cells) cell cultures in 2-D and 3-D, biochemistry, molecular biology, various imaging approaches (confocal analyses, videomicroscopy), gene expression analyses, protein production, and preclinical models of human diseases. Our efforts have recently been focused on characterizing the role of Thrombospondin-1, Angiopoietin-like 4 and Lysysl Oxidase like 2 in regulating angiogenesis and vascular integrity.. By gain-of-function and loss-of-function approaches, both in vitro and in vivo, we are also studying ECM composition, deposition, posttranslational modifications and rearrangement by ECs. Indeed, hypoxia-driven vascular remodeling is dynamically regulated through activities of ECM modifying enzyme, such as Lysysl Oxidase like 2 or Transgluaminase-2 that eventually regulate both matricellular proteins and growth factor availability, that ...
https://www.college-de-france.fr/site/en-cirb/germain.htm
ANGPTL3 (Human) Recombinant Protein (Q01) - (H00027329-Q01) - Products - Abnova
Human ANGPTL3 partial ORF ( NP_055310.1, 361 a.a. - 460 a.a.) recombinant protein with GST-tag at N-terminal. (H00027329-Q01) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=H00027329-Q01
Pro-inflammatory and angiogenic activities of VEGF and angiopoietins in murine sponge/Matrigel modelPro-inflammatory and angiogenic activities of VEGF and angiopoietins in murine sponge/Matrigel model
La dérégulation de la formation et lintégrité des vaisseaux sanguins peut conduire à un état pathologique tel quobservé dans de nombreuses maladies ischémiques telles que: la croissance de tumeur solide, larthrite rhumatoïde, le psoriasis, les rétinopathies et lathérosclérose. Par conséquent, la possibilité de moduler langiogenèse régionale chez les patients souffrant dischémie est cliniquement pertinente. Un élément clé dans linduction de langiogenèse pathologique est une inflammation qui précède et accompagne la formation des nouveaux vaisseaux. Ce phénomène est démontré par laugmentation de la perméabilité vasculaire et le recrutement de monocytes/ macrophages et cellules polynucléaires (neutrophiles). En collaboration avec dautres groupes, nous avons montré que différents facteurs de croissance tels que le facteur de croissance endothélial vasculaire et les angiopoïétines peuvent non seulement promouvoir langiogenèse mais aussi induire diverses ...
https://papyrus.bib.umontreal.ca/xmlui/handle/1866/11796
Biology Animations: Role for Angiopoietins AnimationBiology Animations: Role for Angiopoietins Animation
Biology Animations includes selected, high quality biological animations; about cell biology, microbiology, genetics, immunology, cancer treatments and diagnosis.... ...
http://biology-animations.blogspot.com/2011/05/role-for-angiopoietins-animation.html
Gentaur Molecular :Prospecbio \ Mouse Anti Human Angiopoietin Like Protein 3 ANGPTL3 \ ant-310Gentaur Molecular :Prospecbio \ Mouse Anti Human Angiopoietin Like Protein 3 ANGPTL3 \ ant-310
Gentaur molecular products has all kinds of products like :search , Prospecbio \ Mouse Anti Human Angiopoietin Like Protein 3 ANGPTL3 \ ant-310 for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=2793267&supplier=search&name=Mouse%20Anti%20Human%20Angiopoietin%20Like%20Protein%203%20ANGPTL3
Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density...
TY - JOUR. T1 - Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents. AU - Hammad, Maha M. AU - Abu-Farha, Mohamed. AU - Al-Taiar, Abdullah. AU - Alam-Eldin, Nada. AU - Al-Sabah, Reem. AU - Shaban, Lemia. AU - Al-Mulla, Fahd. AU - Abubaker, Jehad. AU - Rahman, Abdur. PY - 2020/4/14. Y1 - 2020/4/14. N2 - Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to regulate triglyceride metabolism and is increased in obesity and diabetes. However, its role in metabolic diseases in adolescents is not well-studied. In this study, we tested the hypothesis of a positive association between plasma ANGPTL5, and obesity, high sensitivity C-reactive protein (HsCRP) and oxidized low-density lipoprotein (Ox-LDL) in adolescents. Adolescents (N = 431; age 11-14 years) were randomly selected from middle schools in Kuwait. Obesity ...
https://research.dasmaninstitute.org/en/publications/correlation-of-circulating-angptl5-levels-with-obesity-high-sensi
DGIST Scholar: Effect of bexarotene on differentiation of glioblastoma multiforme compared with ATRADGIST Scholar: Effect of bexarotene on differentiation of glioblastoma multiforme compared with ATRA
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor. Since differentiation can attenuate or halt the growth of tumor cells, an image-based phenotypic screening was performed to find out drugs inducing morphological differentiation of GBMs. Bexarotene, a selective retinoid X receptor agonist, showed strong inhibition of neurospheroidal colony formation and migration of cultured primary GBM cells. Bexarotene treatment reduced nestin expression, while significantly increasing glial fibrillary acidic protein (GFAP) expression. The effect of bexarotene on gene expression profile was compared with the activity of all-trans retinoic acid (ATRA), a well-known differentiation inducer. Both drugs largely altered the gene expression pattern into a tumor-ameliorating direction. These drugs increased the gene expression levels of Kruppel-like factor 9 (KLF9), regulator of G-protein signaling 4 (RGS4), growth differentiation factor 15 (GDF15), angiopoietin-like protein 4 (ANGPTL4), and ...
http://scholar.dgist.ac.kr/handle/20.500.11750/2682
ANGPTL3 (human) LANCE Ultra TR-FRET Detection Kit, 500 Assay Points | PerkinElmerANGPTL3 (human) LANCE Ultra TR-FRET Detection Kit, 500 Assay Points | PerkinElmer
Detect and quantitate human angiopoietin-like 3 protein (ANGPTL3) in buffered solution and cell culture supernatants using a homogeneous LANCE Ultra TR-FRET assay.
http://www.perkinelmer.com/product/lance-ultra-angptl3-hu-kit-500pts-trf3016c
ANGPTL3 (human) LANCE Ultra TR-FRET Detection Kit, 10,000 Assay Points | PerkinElmerANGPTL3 (human) LANCE Ultra TR-FRET Detection Kit, 10,000 Assay Points | PerkinElmer
Detect and quantitate human angiopoietin-like 3 protein (ANGPTL3) in buffered solution and cell culture supernatants using a homogeneous LANCE Ultra TR-FRET assay.
http://www.perkinelmer.com/product/lance-ultra-angptl3-hu-kit-10000pts-trf3016m
Expression of ANGPTL2 in cancer - Summary - The Human Protein AtlasExpression of ANGPTL2 in cancer - Summary - The Human Protein Atlas
Expression of ANGPTL2 (ARP2, HARP) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
http://www.proteinatlas.org/ENSG00000136859-ANGPTL2/pathology
ANGPTL7 Mouse | ProSpecANGPTL7 Mouse | ProSpec
ANGPTL7 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 324 amino acids (22-337 a.a.) and having a molecular mass of 37.5kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).
https://www.prospecbio.com/ANGPTL7_Mouse
Angiopoietin Like Protein 8 (ANGPTL8) Polyclonal Antibody, Cat#CAU21004 - BiomatikAngiopoietin Like Protein 8 (ANGPTL8) Polyclonal Antibody, Cat#CAU21004 - Biomatik
Biomatik provides products of ELISA Kits, Antibodies, Proteins, Biochemicals & Enzymes. Also, we deal with the services of Gene Synthesis, Peptide Synthesis, Protein Expression at affordable charges.
https://www.biomatik.com/antibodies/angiopoietin-like-protein-8-angptl8-polyclonal-antibody-cat-cau21004/
AGF Names Vice-President of Global Consultant RelationsAGF Names Vice-President of Global Consultant Relations
/PRNewswire/ - AGF Management Limited (AGF) is pleased to announce the appointment of Christopher Adey as Vice-President of Global Consultant Relations, AGF...
https://www.prnewswire.com/news-releases/agf-names-vice-president-of-global-consultant-relations-148103165.html
FIAF - International Federation of Film ArchivesFIAF - International Federation of Film Archives
The International Federation of Film Archives (FIAF) brings together institutions dedicated to rescuing of films both as art and as historical documents
http://www.fiafnet.org/pages/Publications/Other-Books.html
FIAF - International Federation of Film ArchivesFIAF - International Federation of Film Archives
The International Federation of Film Archives (FIAF) brings together institutions dedicated to rescuing of films both as art and as historical documents
http://www.fiafnet.org/pages/E-Resources/Symposium-Documents.html
Human Gene ANGPTL7 (ENST00000376819.4) Description and Page IndexHuman Gene ANGPTL7 (ENST00000376819.4) Description and Page Index
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model. ...
https://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=ENST00000376819.4&hgg_prot=uc001ase.6&hgg_chrom=chr1&hgg_start=11189354&hgg_end=11195981&hgg_type=knownGene&db=hg38&hgsid=801177985_9EHK8MaSrPOpl5GhavOGtwlXgDKB
Recebimento de Mensagem com VirusRecebimento de Mensagem com Virus
Mensagem com vírus enviada aparentemente pelo remetente indicado. --- Scan information follows --- Result: Virus Detected Virus Name: [email protected] File Attachment: document_all02c.zip Attachment Status: deleted --- Original message information follows --- From: [email protected] To: [email protected] Date: Fri, 23 Apr 2004 18:35:03 -0300 Subject: Re: Hi Received: from agf2.agf.com.br ([128.250.115.2]) by agfrelay.agf.com.br (SAVSMTP 3.1.5.43) with SMTP id M2004042318393326700 for ,[email protected],; Fri, 23 Apr 2004 18:39:33 -0300 ...
http://lists.gnu.org/archive/html/bug-ghostscript/2004-04/msg01852.html
AngiopoietinAngiopoietin
... -1 and angiopoietin-2 can form dimers, trimers, and tetramers. Angiopoietin-1 has the ability to form higher order ... is demonstrated by an increased ratio of angiopoietin-2 and angiopoietin-1 in blood serum. To be specific, angiopoietin levels ... Angiopoietin-1 encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa whereas angiopoietin-2 encodes a 496 ... Angiopoietin-2 has been proposed as a biomarker in different cancer types. Angiopoietin-2 expression levels are proportional to ...
https://en.wikipedia.org/wiki/Angiopoietin
Angiopoietin receptorAngiopoietin receptor
The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind ... The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis). The angiopoietins are ... In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4). Ang1 and ... But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.[citation ...
https://en.wikipedia.org/wiki/Angiopoietin_receptor
Angiopoietin 1Angiopoietin 1
... is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in ... increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta. This suggests that ... Dunk C, Shams M, Nijjar S (2000). "Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration ... Cheung AH, Stewart RJ, Marsden PA (1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): ...
https://en.wikipedia.org/wiki/Angiopoietin_1
Angiopoietin-like proteinsAngiopoietin-like proteins
The Angiopoietin-like proteins are proteins structurally like the angiopoietins but which do not bind to the angiopoietin ... Angiopoietin-related protein 1, gene ANGPTL1 Angiopoietin-related protein 2, gene ANGPTL2 Angiopoietin-related protein 3, gene ... Angiopoietin-related protein 7, gene ANGPTL7 Angiopoietin-related protein 8, gene ANGPTL8, also known as lipasin because of its ... gene ANGPTL4 Angiopoietin-related protein 5, gene ANGPTL5, mainly expressed in adult human heart. Angiopoietin-related protein ...
https://en.wikipedia.org/wiki/Angiopoietin-like_proteins
Angiopoietin-related protein 1Angiopoietin-related protein 1
Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this ... Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein ...
https://en.wikipedia.org/wiki/Angiopoietin-related_protein_1
Angiopoietin-related protein 7Angiopoietin-related protein 7
... is a protein that in humans is encoded by the ANGPTL7 gene. It is one of the 8 angiopoietin-like ... "Entrez Gene: ANGPTL7 angiopoietin-like 7". Angiopoietin-like proteins: a comprehensive look Tanigawa, Yosuke; Wainberg, Michael ... Peek R, Kammerer RA, Frank S, Otte-Holler I, Westphal JR (Jan 2002). "The angiopoietin-like factor cornea-derived transcript 6 ...
https://en.wikipedia.org/wiki/Angiopoietin-related_protein_7
Angiopoietin-related protein 2Angiopoietin-related protein 2
Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted ... Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 ... and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J Biol ... Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific ...
https://en.wikipedia.org/wiki/Angiopoietin-related_protein_2
Hes3 signaling axisHes3 signaling axis
Activation of the Tie2 receptor by the ligand Angiopoietin 2. This has been shown in vitro and in vivo. Activation of the ... Activation of the signaling pathway by Delta4, Angiopoietin 2, insulin, or a combination of the three and a JAK inhibitor ... Angiopoietin 2). Hes3, in turn, by regulating the expression of Shh and potentially other factors, can also exert an effect on ... Angiopoietin 2, insulin, or a combined treatment consisting of all three factors and an inhibitor of JAK) induce the increase ...
https://en.wikipedia.org/wiki/Hes3_signaling_axis
ANGPT4ANGPT4
Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene. Angiopoietins are proteins with important roles in ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3-4): 147-54. ... "Entrez Gene: ANGPT4 angiopoietin 4". Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser. ...
https://en.wikipedia.org/wiki/ANGPT4
ANGPTL3ANGPTL3
Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene. The protein encoded by ... "Entrez Gene: ANGPTL3 angiopoietin-like 3". Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, et al. (December ... The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced ... Kaplan R, Zhang T, Hernandez M, Gan FX, Wright SD, Waters MG, Cai TQ (January 2003). "Regulation of the angiopoietin-like ...
https://en.wikipedia.org/wiki/ANGPTL3
NesvacumabNesvacumab
It targets the protein angiopoietin 2. As of May 2017[update], it is in Phase II clinical trials for the treatment of diabetic ... "Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of ...
https://en.wikipedia.org/wiki/Nesvacumab
Gelareh ZadehGelareh Zadeh
Her doctoral research looked at the role of angiopoietins in astrocytoma angiogenesis. After earning her doctorate Zadeh moved ... Zadeh, Gelareh (2007). Role of angiopoietins and Tie2/TEK in astrocytoma angiogenesis (Thesis). OCLC 234132296. "Dr. Gelareh ...
https://en.wikipedia.org/wiki/Gelareh_Zadeh
ANGPTL8ANGPTL8
Three dimensional structure of none of the members of Angiopoietin like proteins (ANGPTLs) is available up until now.[when?] ... "Atypical angiopoietin-like protein that regulates ANGPTL3". Proceedings of the National Academy of Sciences of the United ... is a novel but atypical member of the angiopoietin-like protein family". Biochemical and Biophysical Research Communications. ... "Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways". Genomics. ...
https://en.wikipedia.org/wiki/ANGPTL8
TEK tyrosine kinaseTEK tyrosine kinase
January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig- ... angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization". Circulation Research. 83 (3): 233-40. ... Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the ... Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (November 2001). "Dok-R plays a pivotal role in angiopoietin-1- ...
https://en.wikipedia.org/wiki/TEK_tyrosine_kinase
ANGPT2ANGPT2
Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 ... Xu Y, Yu Q (September 2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its ... Cheung AH, Stewart RJ, Marsden PA (March 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 ( ... "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ...
https://en.wikipedia.org/wiki/ANGPT2
AngiogenesisAngiogenesis
The angiopoietins, Ang1 and Ang2, are required for the formation of mature blood vessels, as demonstrated by mouse knock out ... Thurston G (October 2003). "Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis". ...
https://en.wikipedia.org/wiki/Angiogenesis
EvinacumabEvinacumab
... binds to the angiopoietin-like protein 3 (ANGPTL3). ANGPTL3 slows the function of certain enzymes that break down ...
https://en.wikipedia.org/wiki/Evinacumab
Epithelial-mesenchymal transitionEpithelial-mesenchymal transition
Li JJ, Huang YQ, Basch R, Karpatkin S (February 2001). "Thrombin induces the release of angiopoietin-1 from platelets". ... Angiopoietin-1) and cytokines including the EMT inducer TGF-β. The release of TGF-β by platelets in blood vessels near primary ...
https://en.wikipedia.org/wiki/Epithelial–mesenchymal_transition
ANGPTL4ANGPTL4
July 2007). "Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin ... Angiopoietin-like 4 is a protein that in human is encoded by the ANGPTL4 gene. Alternatively spliced transcript variants ... July 2017). "Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen ... June 2015). "Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative ...
https://en.wikipedia.org/wiki/ANGPTL4
PericytePericyte
Angiopoietin 2 can act as an antagonist to Tie-2, destabilizing the endothelial cells, which results in less endothelial cell ... Angiopoietin 1 and Tie-2 signaling is essential for maturation and stabilization of endothelial cells. Platelet-derived growth ... Similar to the inhibition of the PDGF pathway, angiopoietin 2 reduces levels of pericytes, leading to diabetic retinopathy. ... "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...
https://en.wikipedia.org/wiki/Pericyte
N-AcetylmannosamineN-Acetylmannosamine
Chugh, S; Macé, C; Clement, L; Del Nogal, A; Marshall, C (2014). "Angiopoietin-like 4 based therapeutics for proteinuria and ...
https://en.wikipedia.org/wiki/N-Acetylmannosamine
Koh Gou YoungKoh Gou Young
"Attenuated angiopoietin-Tie2 signaling regresses Schlemm's canal integrity and induces glaucoma". Journal of Clinical ...
https://en.wikipedia.org/wiki/Koh_Gou_Young
Thomas N. SatoThomas N. Sato
... and angiopoietins, that play the key roles in the blood vessel formation. National Science Contest for Elementary School ... "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis". Cell. 87 (7): 1171-1180. doi: ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...
https://en.wikipedia.org/wiki/Thomas_N._Sato
FCN3FCN3
Zeng L, Dai J, Ying K (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet ...
https://en.wikipedia.org/wiki/FCN3
GRLF1GRLF1
Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). "Angiopoietin-1 ...
https://en.wikipedia.org/wiki/GRLF1
Michele De PalmaMichele De Palma
He later showed that inhibition of the Tie2-ligand Angiopoietin 2 induces tumor regression and inhibits metastasis by ... He also identified expression of Angiopoietin 2 as an adaptive resistance mechanism upon anti-angiogenic treatment by VEGF ... "Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade". Cell Reports. 8 (3): 696-706. doi:10.1016/j. ... "Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade". Science ...
https://en.wikipedia.org/wiki/Michele_De_Palma
Host response to cancer therapyHost response to cancer therapy
Regulation by Hypoxia and Angiopoietin-2". Cancer Research. 67 (18): 8429-8432. doi:10.1158/0008-5472.CAN-07-1684. ISSN 0008- ...
https://en.wikipedia.org/wiki/Host_response_to_cancer_therapy
Subdural hematomaSubdural hematoma
Mediators that promote angiogenesis are angiopoietin and vascular endothelial growth factor (VEGF). Prostaglandin E2 promotes ...
https://en.wikipedia.org/wiki/Subdural_hematoma
Vascular endothelial growth factorVascular endothelial growth factor
Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in ... The expression of angiopoietin-2 in the absence of VEGF leads to endothelial cell death and vascular regression. Conversely, a ...
https://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor
FCN1FCN1
2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159-62. doi: ...
https://en.wikipedia.org/wiki/FCN1
angiopoietin-1 | Heartangiopoietin-1 | Heart
Heart Oct 2010, 96 (Suppl 3) A14-A15; DOI: 10.1136/hrt.2010.208967.44 ...
https://heart.bmj.com/keyword/angiopoietin-1
Frontiers | ETS1, ELK1, and ETV4 Transcription Factors Regulate Angiopoietin-1 Signaling and the Angiogenic Response in...Frontiers | ETS1, ELK1, and ETV4 Transcription Factors Regulate Angiopoietin-1 Signaling and the Angiogenic Response in...
Background: Angiopoietin-1 (Ang-1) is the main ligand of Tie-2 receptors. It promotes endothelial cell (EC) survival, migration ... Background: Angiopoietin-1 (Ang-1) is the main ligand of Tie-2 receptors. It promotes endothelial cell (EC) survival, migration ... 2016). Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts. J. ... Kim, I., Kim, H. G., So, J. N., Kim, J. H., Kwak, H. J., and Koh, Y. (2000). Angiopoietin-1 regulates endothelial cell survival ...
https://www.frontiersin.org/articles/10.3389/fphys.2021.683651/full
Rat Angiopoietin 4 ELISA kit, AMS.E02A0637 | AMSBIORat Angiopoietin 4 ELISA kit, AMS.E02A0637 | AMSBIO
This ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
https://www.amsbio.com/rat-angiopoietin-4-elisa-kit-amse02a0637
Medical Science Monitor | Ratio of Angiopoietin-2 to Angiopoietin-1 predicts mortality in acute lung injury induced by paraquat...Medical Science Monitor | Ratio of Angiopoietin-2 to Angiopoietin-1 predicts mortality in acute lung injury induced by paraquat...
... angiopoietin-2 (Ang-2), and von Willebrand factor (VWF) reflecting endothelial cell injury, we investigated the initial ... induced endothelial cell injury is involved in early death after paraquat intoxication and concentrations of angiopoietin-1 ( ... Ratio of Angiopoietin-2 to Angiopoietin-1 predicts mortality in acute lung injury induced by paraquat Jae-Sung ChoiAEF, Kyung-A ... Keywords: Paraquat - poisoning, Angiopoietin-2 - blood, Angiopoietin-1 - blood, Acute Lung Injury - mortality, Survival ...
https://medscimonit.com/abstract/index/idArt/883730
Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese ...Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese ...
Keywords: Angiopoietin-2, colorectal cancer, polymorphism Citation styles. APA Copy. Du, Z., Tang, C.H., Li, L.J., Kang, L., ... Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese. Int J ... Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese. Int J ... Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese. Int J ...
https://medsci.org/v17p0097
You searched for angiopoietin-2 | BiomedicaYou searched for angiopoietin-2 | Biomedica
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Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis | BMC Cancer |...Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis | BMC Cancer |...
Angiopoietin-like 4 (ANGPTL4) drives the progression and metastasis of many solid tumours, but has not been described in ... From: Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4468-5/figures/4
Human - Angiopoietin-Like Protein 4 - from Sheep - Antibodies | BioVendor Research and Diagnostics ProductsHuman - Angiopoietin-Like Protein 4 - from Sheep - Antibodies | BioVendor Research and Diagnostics Products
Human - Angiopoietin-Like Protein 4 - from Sheep - Antibodies. Product filter Angiopoietin-Like Protein 4 molecule Acylation- ... Angiopoietin-Like Protein 3 Angiopoietin-Like Protein 4 Angiostatin Annexin A1 Apolipoprotein D Apolipoprotein M Apoptosis ... Angiopoietin-Like Protein 4 (HEK) Human, Sheep Polyclonal Antibody Type: Polyclonal Antibody. ...
https://www.biovendor.com/antibodies?molecule=Angiopoietin-Like+Protein+4&species=Human&host=Sheep
Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 durin by Amy S Erickson Hagen, Ryan J Orbus et al."Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 durin" by Amy S Erickson Hagen, Ryan J Orbus et al.
Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are angiogenic growth factors expressed in the placenta, and compete for ... Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are angiogenic growth factors expressed in the placenta, and compete for ... Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 during placental development in an ovine model of placental ...
https://ir.lib.uwo.ca/paedpub/2768/
A 7-day high-PUFA diet reduces angiopoietin-like protein 3 and 8 responses and postprandial triglyceride levels in healthy...A 7-day high-PUFA diet reduces angiopoietin-like protein 3 and 8 responses and postprandial triglyceride levels in healthy...
... have beneficial effects on hypertriglyceridemia although their effect on angiopoietin-like proteins (ANGPTLs), specifically ... A 7-day high-PUFA diet reduces angiopoietin-like protein 3 and 8 responses and postprandial triglyceride levels in healthy ...
https://bmcnutr.biomedcentral.com/articles/10.1186/s40795-018-0262-7/metrics
Angiopoietins and angiopoietin-like proteins in angiogenesis<...
Angiopoietins and angiopoietin-like proteins in angiogenesis. Tohru Morisada, Yoshiaki Kubota, Takashi Urano, Toshio Suda, ... Angiopoietins and angiopoietin-like proteins in angiogenesis. / Morisada, Tohru; Kubota, Yoshiaki; Urano, Takashi et al. ... Morisada T, Kubota Y, Urano T, Suda T, Oike Y. Angiopoietins and angiopoietin-like proteins in angiogenesis. Endothelium: ... Angiopoietins and angiopoietin-like proteins in angiogenesis. In: Endothelium: Journal of Endothelial Cell Research. 2006 ; Vol ...
https://keio.pure.elsevier.com/en/publications/angiopoietins-and-angiopoietin-like-proteins-in-angiogenesis
Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD - Northumbria Research LinkLevels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD - Northumbria Research Link
Angiopoietin-1 (Ang-1), is an essential mediator of angiogenesis by establishing vascular integrity, whereas angiopoietin-2 ( ... Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD ... We determined the levels of angiopoietins in sputum supernatants of patients with COPD and investigated their possible ... Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD. Cytokine, 58 (3). pp. 455-460. ISSN 1043- ...
https://nrl.northumbria.ac.uk/id/eprint/32867/
Bovine Angiopoietin 1 (ANGPT1) ELISA Kit, Cat#EKU02356 - BiomatikBovine Angiopoietin 1 (ANGPT1) ELISA Kit, Cat#EKU02356 - Biomatik
Bovine Angiopoietin 1 (ANGPT1) ELISA Kit, Cat#EKU02356. Write a Review Write a Review. × ... Bovine Angiopoietin 1 (ANGPT1) ELISA Kit, Cat#EKU02356. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars ( ... This assay has high sensitivity and excellent specificity for detection of Angiopoietin 1 (ANGPT1). No significant cross- ... reactivity or interference between Angiopoietin 1 (ANGPT1) and analogues was observed.. Test principle. This assay employs the ...
https://www.biomatik.com/elisa-kits/cattle-angiopoietin-1-angpt1-elisa-kit-cat-eku02356/
Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: Possible in vivo regulation via induction of proteases<...
Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma : Possible in vivo regulation via induction of proteases. ... Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma : Possible in vivo regulation via induction of proteases. ... T1 - Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma. T2 - Possible in vivo regulation via induction of ... Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: Possible in vivo regulation via induction of proteases」の研 ...
https://kyushu-u.pure.elsevier.com/ja/publications/angiopoietin-2-is-related-to-tumor-angiogenesis-in-gastric-carcin
Angiopoietin-2 Promotes Pathological Angiogenesis And Is A Novel Therapeutic Target In Murine Non-alcoholic Fatty Liver Disease...Angiopoietin-2 Promotes Pathological Angiogenesis And Is A Novel Therapeutic Target In Murine Non-alcoholic Fatty Liver Disease...
This original study demonstrates that serum angiopoietin-2 levels are increased in patients with NASH and correlate with liver ... The main source of hepatic angiopoietin-2 was liver sinusoidal endothelial cells (LSECs). Inhibiting angiopoietin-2 levels ... Angiopoietin-2 promotes pathological angiogenesis and is a novel therapeutic target in murine non-alcoholic fatty liver disease ... This original study demonstrates that serum angiopoietin-2 levels are increased in patients with NASH and correlate with liver ...
https://pannash.org/angiopoietin-2-promotes-pathological-angiogenesis-and-is-a-novel-therapeutic-target-in-murine-non-alcoholic-fatty-liver-disease/
Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis...Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis...
Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis ... Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis ... In mature vessels, angiopoietins control vascular permeability, inflammation and remodeling. A crucial role of angiopoietins is ... In mature vessels, angiopoietins control vascular permeability, inflammation and remodeling. A crucial role of angiopoietins is ...
https://iris.uniroma1.it/handle/11573/880926
Angiopoietin-tie2 - Mannin Research Inc.Angiopoietin-tie2 - Mannin Research Inc.
The data suggests that the Angiopoietin-Tie2 signaling pathway is a promising therapeutic target to prevent... ...
https://mannin.ca/tag/angiopoietin-tie2/
Host angiopoietin-2 inhibits tumor growth and angiogenesis in the liver - Department of Oncology
Host angiopoietin-2 inhibits tumor growth and angiogenesis in the liver Im JH., Balathasan L., Yameen S., Tapmeier T., Hill S ...
https://www.oncology.ox.ac.uk/publications/624197
Angiopoietin 2 Antibody | R32640 NSJ BioreagentsAngiopoietin 2 Antibody | R32640 NSJ Bioreagents
This highly specific Angiopoietin 2 antibody is suitable for use in WB, IHC-P and ELISA and is guaranteed to work as stated on ... This Angiopoietin 2 antibody is available for research use only. Review this product on BioCompare and get a $20 Amazon gift ... After reconstitution, the Angiopoietin 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at ... ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1 ...
https://www.nsjbio.com/tds/angiopoietin-2-antibody-r32640
Bovine Angiopoietin 1 (ANGPT1) ELISA Kit - BiossBovine Angiopoietin 1 (ANGPT1) ELISA Kit - Bioss
Home › ELISA Kits › Bovine Angiopoietin 1 (ANGPT1) ELISA Kit Bovine Angiopoietin 1 (ANGPT1) ELISA Kit. ...
https://www.biossusa.com/collections/elisa-kits/products/bskb65404
Kounis SyndromeKounis Syndrome
Angiogenin/angiopoietin. Endothelial growth factor. Fibroblast growth factor α and basic. Interleukin 8. ...
https://www.medscape.com/viewarticle/732843
Rat ANG1 (Angiopoietin 1) ELISA Kit - BidScientific.com
Rat ANG1 (Angiopoietin 1) ELISA Kit. E-EL-R0626 Regular price $495.00. $426.00 You Pay ...
https://www.bidscientific.com/products/e-el-r0626
Human Angiopoietin-related protein 1(ANGPTL1) ELISA kit | Doron ScientificHuman Angiopoietin-related protein 1(ANGPTL1) ELISA kit | Doron Scientific
MMRRC:041996-MUMMRRC:041996-MU
Name: angiopoietin-like 1. Synonyms: ANGPT3, ANGY, ARP1, ANG3, 2810039D03Rik, ANG-3, ANG3 ...
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=41996
Choroidal Neovascularization (CNV) Medication: Anti-VEGF therapy, Photosensitizers for photodynamic therapy, Ophthalmics, VEGF...
Angiopoietins as Potential Targets in Management of Retinal Disease. Clin Ophthalmol. 2021. 15:3747-3755. [QxMD MEDLINE Link]. ... Faricimab is a monoclonal antibody that targets both VEGF and Ang-2 (angiopoietin 2) ...
https://www.staging.medscape.com/answers/1190818-172097/which-medications-in-the-drug-class-ophthalmics-vegf-inhibitors-are-used-in-the-treatment-of-choroidal-neovascularization-cnv
IMSEAR at SEARO: Angiopoietin like protein 3 (Angptl3), fatty acid binding protein 4 (FABP4) and homeostasis model assessment...
Angiopoietin like protein 3 (Angptl3), fatty acid binding protein 4 (FABP4) and homeostasis model assessment of insulin ... Angiopoietin like protein 3 (Angptl3), fatty acid binding protein 4 (FABP4) and homeostasis model assessment of insulin ...
https://imsear.searo.who.int/handle/123456789/148943
Heier Talks Anti-Angiopoietin Programs, Clinical Trials & Red Sox | Ophthalmology Innovation SourceHeier Talks Anti-Angiopoietin Programs, Clinical Trials & Red Sox | Ophthalmology Innovation Source
The angiopoietin Tie2 pathway is much more complex, or at least to us at this stage in our understanding, its much more ... Heier Talks Anti-Angiopoietin Programs, Clinical Trials & Red Sox March 2, 2016 ... gives an update from the Angiogenesis conference about the advancing anti-angiopoietin programs. ...
https://ois.net/heier-talks-anti-angiopoietin-programs-clinical-trials-red-sox/
Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration<...
Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration. Chungho Kim, Hyo Seon ... Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration. / Kim, Chungho; Lee, Hyo ... Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration. Blood. 2011 Jan 27;117(4 ... Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration. In: Blood. 2011 ; Vol. ...
https://koreauniv.pure.elsevier.com/en/publications/epithinprss14-proteolytically-regulates-angiopoietin-receptor-tie
Science Clips - Volume 15, Issue 4, January 24, 2023Science Clips - Volume 15, Issue 4, January 24, 2023
Angiopoietin-like4 is a novel marker of COVID-19 severity. Bhatraju PK, Morrell ED, Stanaway IB, Sathe NA, Srivastava A, ... Angiopoietin-like 4 (ANGPTL4) is a protein secreted in response to hypoxic and nutrient-poor conditions that has a variety of ...
https://www.cdc.gov/library/sciclips/issues/v15issue4.html
Reflecting endothelialANGPTL3ProteinAngiogenesisTie2ANG1ReceptorAngiogenicAng2Endothelial CellsANGPT1PlacentalAntibodyInflammationLigandInhibitorsGeneRegulatorsSerumProteinsMutationsInflammatoryTIE2ProteinsVEGFLigandsANGPT2ELISAANG2Endothelial cellAntagonistExpressionGeneInhibitsSolubleSpecificityApoptosisPeptibodyPlasmaTie1Protein calledReceptorsBlood vessel
Reflecting endothelial1
  • Background: To determine whether initial reactive oxygen species (ROS)-induced endothelial cell injury is involved in early death after paraquat intoxication and concentrations of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and von Willebrand factor (VWF) reflecting endothelial cell injury, we investigated the initial endothelial cell injury marker involved in the pathogenesis of death within 5 days after paraquat ingestion. (medscimonit.com)
ANGPTL34
  • IMSEAR at SEARO: Angiopoietin like protein 3 (Angptl3), fatty acid binding protein 4 (FABP4) and homeostasis model assessment of insulin resistance (HOMA-IR) among Indonesian obese non diabetic males. (who.int)
  • AIMS : Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. (ox.ac.uk)
  • This medicine is an ANGPTL3 (angiopoietin-like protein 3) inhibitor. (mayoclinic.org)
  • Evinacumab is a recombinant human monoclonal antibody that binds to and inhibits angiopoietin-like 3 (ANGPTL3). (medscape.com)
Protein5
  • ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. (nsjbio.com)
  • Amino acids E180-D283 from the human protein were used as the immunogen for the Angiopoietin 2 antibody. (nsjbio.com)
  • Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis. (ox.ac.uk)
  • Excessive angiopoietin-like protein (ANGPTL)-2 signaling causes chronic tissue inflammation, promoting development and progression of aging-related diseases. (fujita-hu.ac.jp)
  • Angiopoietin-like protein 6 in patients with obesity, type 2 diabetes mellitus, and anorexia nervosa: The influence of very low-calorie diet, bariatric surgery, and partial realimentation. (medscape.com)
Angiogenesis9
  • The TEK receptor tyrosine kinase (Tie-2) and its ligand angiopoietin-1 (ANPGT1, Ang-1) have emerged as important regulators of angiogenesis, both in adults and in embryos. (frontiersin.org)
  • Interestingly, Angptls also function in angiogenesis through regulating survival and migration of endothelial cells, although Angptls do not bind the angiopoietin receptor Tie2. (elsevier.com)
  • Here, the authors review current findings relating to the roles of angiopoietins and Angptls in vascular biology and discuss molecular mechanisms relevant to these factors and angiogenesis. (elsevier.com)
  • Angiopoietin-1 (Ang-1), is an essential mediator of angiogenesis by establishing vascular integrity, whereas angiopoietin-2 (Ang-2) acts as its natural inhibitor. (northumbria.ac.uk)
  • Angiopoietin-2 Promotes Pathological Angiogenesis And Is A Novel Therapeutic Target In Murine Non-alcoholic Fatty Liver Disease. (pannash.org)
  • Inhibiting angiopoietin-2 levels using the angiopoietin-2/Tie2 receptor inhibiting peptibody L1-10 reduced hepatic angiogenesis and normalized vascular microarchitecture. (pannash.org)
  • These findings provide evidence for angiopoietin -2 inhibition as a therapeutic strategy to target pathological angiogenesis in NASH. (pannash.org)
  • Jeff Heier, MD , is the Director of the Vitreoretinal Service and the Director of Retina Research at Ophthalmic Consultants of Boston (OCB) gives an update from the Angiogenesis conference about the advancing anti-angiopoietin programs. (ois.net)
  • As a member of the angiopoietin family, Angiopoietin-2 (Ang-2) plays an irreplaceable role in angiogenesis. (nih.gov)
Tie26
  • Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling. (elsevier.com)
  • It has been reported that the angiopoietin/Tie2 signal is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. (elsevier.com)
  • More recent studies demonstrate that angiopoietin/Tie2 signaling is also required for lymphangiogenesis. (elsevier.com)
  • The data suggests that the Angiopoietin-Tie2 signaling pathway is a promising therapeutic target to prevent. (mannin.ca)
  • The angiopoietin Tie2 pathway is much more complex, or at least to us at this stage in our understanding, it's much more complex. (ois.net)
  • The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation. (bvsalud.org)
ANG13
  • The angiogenic growth factors, Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2), are crucial regulators of vessel formation and maintenance starting with embryonic development and continuing through life. (uniroma1.it)
  • In this review, we present a summary of the role of Ang1 and Ang2, their involvement in diabetic complications, and novel therapeutic strategies targeting angiopoietins to ameliorate vascular health in metabolic disorders. (uniroma1.it)
  • Angiopoietin-1 (Ang1) has been defined as a ligand from the endothelial selective receptor tyrosine kinase (RTK), Link2. (conferencedequebec.org)
Receptor1
  • Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are angiogenic growth factors expressed in the placenta, and compete for binding to a common receptor, Tunica interna endothelial cell kinase-2 (Tie-2). (uwo.ca)
Angiogenic1
  • Real-time polymerase chain reaction demonstrated significant upregulation of angiopoietin-2 (Ang-2) in ischemic myocardium, to a greater extent than other classical angiogenic factors. (univ-angers.fr)
Ang21
  • Angiopoietin-2 (Ang2), an endothelial tyrosine kinase, is involved in CRC progression, but little is known about the association between single nucleotide polymorphisms (SNPs) and diagnosis or prognosis of CRC. (medsci.org)
Endothelial Cells1
  • The main source of hepatic angiopoietin-2 was liver sinusoidal endothelial cells (LSECs). (pannash.org)
ANGPT12
  • This assay has high sensitivity and excellent specificity for detection of Angiopoietin 1 (ANGPT1). (biomatik.com)
  • No significant cross-reactivity or interference between Angiopoietin 1 (ANGPT1) and analogues was observed. (biomatik.com)
Placental3
  • Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 durin" by Amy S Erickson Hagen, Ryan J Orbus et al. (uwo.ca)
  • Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 during placental development in an ovine model of placental insufficiency-fetal growth restriction. (uwo.ca)
  • IHC testing of FFPE human placental tissue with Angiopoietin 2 antibody at 1ug/ml. (nsjbio.com)
Antibody6
  • Western blot testing of human HepG2 cell lysate with Angiopoietin 2 antibody. (nsjbio.com)
  • This Angiopoietin 2 antibody is available for research use only. (nsjbio.com)
  • Optimal dilution of the Angiopoietin 2 antibody should be determined by the researcher. (nsjbio.com)
  • After reconstitution, the Angiopoietin 2 antibody can be stored for up to one month at 4oC. (nsjbio.com)
  • Western blot analysis of extracts from various cell lines using Angiopoietin-2 (D200) Antibody (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). (cellsignal.com)
  • The absence of angiopoietin-2 expression in A-431 cell extracts is consistent with molecular and proteomic expression profiling data, confirming specificity of the antibody. (cellsignal.com)
Inflammation4
  • This original study demonstrates that serum angiopoietin-2 levels are increased in patients with NASH and correlate with liver steatosis, inflammation and hepatocyte ballooning, but not with liver fibrosis. (pannash.org)
  • In mature vessels, angiopoietins control vascular permeability, inflammation and remodeling. (uniroma1.it)
  • A crucial role of angiopoietins is to drive vascular inflammation from the active to the quiescent state, enabling restoration of tissue homeostasis. (uniroma1.it)
  • Association between inflammation, angiopoietins, and disease severity in critically ill COVID-19 patients: a prospective study. (amedeo.com)
Ligand1
  • Angiopoietin-1 (Ang-1) is the main ligand of Tie-2 receptors. (frontiersin.org)
Inhibitors1
  • Other agents (eg, leukotriene inhibitors, N -acetylcysteine, angiopoietin-1) have shown benefit in animal studies. (medscape.com)
Gene1
  • Du Z, Tang CH, Li LJ, Kang L, Zhao J, Jin L, Wang CQ, Su CM. Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese. (medsci.org)
Regulators1
  • Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. (medlineplus.gov)
Serum3
  • Serum was stored for measurement of levels of Angiopoietin (Ang)-1, Ang-2, soluble (s)P-selectin, sE-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and platelet and endothelial cell adhesion molecule-1. (rug.nl)
  • No significant differences in serum levels of the Angiopoietins or soluble cellular adhesion molecules between groups were observed at start of antibiotic treatment nor after 48-72 h. (rug.nl)
  • Serum was stored for measurement of levels of Angiopoietin (Ang)-1, Ang-2, soluble (s)P-selectin, sE-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and platelet and endothelial cell adhesion molecule-1.Results: Fifty-one children were included of whom 10 had a positive blood culture. (rug.nl)
Proteins1
  • The authors and several other groups have identified six angiopoietin-like proteins (Angptls) containing a coiled-coil domain and a fibrinogen-like domain, both of which are characteristic of angiopoietins. (elsevier.com)
Mutations1
  • Mechanisms include mutations of the genes encoding coagulation factor XII, angiopoietin-1, plasminogen and as yet undefined factors. (cdc.gov)
Inflammatory1
  • We determined the levels of angiopoietins in sputum supernatants of patients with COPD and investigated their possible association with mediators and cells involved in the inflammatory and remodeling process. (northumbria.ac.uk)
TIE216
  • During angiogenesis, ANG2 exerts its effects via the angiopoietin-1/TIE2 receptor signaling system on endothelial cells. (tecomedical.com)
  • Interestingly, the hemodynamic alterations associated with endothelial-specific overexpression of ANG2 and the loss of capillary-associated pericytes were reversed by intravenous injections of adeno-associated viruses (AAVs) transducing cDNA for angiopoietin 1, a TIE2 ligand that antagonizes ANG2, or AAVs encoding PDGFB, a chemoattractant for pericytes. (mpg.de)
  • Since Angiopoetin-1 signaling through the Tie2 receptor on endothelial cells opposes microvascular perturbations in other disease contexts, we used a preclinical Angiopoietin-1 mimic called Vasculotide to investigate its effect on skin radiation toxicity using a preclinical model. (biomedcentral.com)
  • Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth. (ox.ac.uk)
  • Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling. (elsevier.com)
  • It has been reported that the angiopoietin/Tie2 signal is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. (elsevier.com)
  • More recent studies demonstrate that angiopoietin/Tie2 signaling is also required for lymphangiogenesis. (elsevier.com)
  • Interestingly, Angptls also function in angiogenesis through regulating survival and migration of endothelial cells, although Angptls do not bind the angiopoietin receptor Tie2. (elsevier.com)
  • Angiopoietins are ligands of the endothelial cell tyrosine kinase receptor Tie2. (crcm-marseille.fr)
  • Angiopoietin-1 (Ang-1) is widely expressed in human normal adult tissues and promotes blood vessel maturation and stabilization by inducing Tie2 receptor phosphorylation. (crcm-marseille.fr)
  • Second, we are exploring new mechanisms and treatments for hepatorenal syndrome by examining regulators of vascular inflammation and endothelial cell dysfunction (such as Angiopoietin/Tie2 signaling). (massgeneral.org)
  • [1] [2] Also known as TIE2 , it is an angiopoietin receptor . (wikidoc.org)
  • Trebananib is designed to bind to both angiopoietin-1 and -2 (Ang1 and Ang2), and inhibit their interaction with the Tie2 receptor. (takeda.com)
  • The molecular function of TIE1 is not completely understood, as it does not directly bind the angiopoietin growth factors, which are the ligands for TEK (TIE2). (atlasgeneticsoncology.org)
  • Tie2, on the other hand, has been studied extensively and has four known binding ligands, angiopoietin (Ang) 1-4 (reviewed in ref. 2 ). (aacrjournals.org)
  • Recent reports have identified a key role of the angiopoietin-Tie2 pathway. (renalresearch.com)
Proteins7
  • Circulating angiopoietin-like proteins in metabolic-associated fatty liver disease: a systematic review and meta-analysis. (nih.gov)
  • The authors and several other groups have identified six angiopoietin-like proteins (Angptls) containing a coiled-coil domain and a fibrinogen-like domain, both of which are characteristic of angiopoietins. (elsevier.com)
  • Angiopoietins are proteins with important roles in vascular development and angiogenesis. (elisa-kits.de)
  • Two domains characterize the angiopoietin family of proteins: an N-terminal coiled-coil domain that mediates homo-oligomerization, and a C-terminal fibrinogen-like domain that binds Tie-2 The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. (elisa-kits.de)
  • The family of angiopoietin-like (ANGPTL) proteins consists of 8 members (ANGPTL1-8) that have disparate effects on physiology. (elsevier.com)
  • Most importantly, inhibiting both VEGF and angiopoietin-like 4 reduced angiogenesis more than targeting just one of the proteins. (nih.gov)
  • Angiopoietin-like proteins (ANGPTLs), which comprise 7 members (ANGPTL1-ANGPTL7), structurally resemble angiopoietins. (deepdyve.com)
VEGF12
  • To determine the temporal expression of vascular growth factors during the lifespan of the primate corpus luteum, experiments were designed to detect mRNA for vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1 and Ang-2 and to localize protein expression for VEGF in macaque luteal tissue during the menstrual cycle. (oregonstate.edu)
  • Dual inhibition of angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF)-A with faricimab, the first bispecific antibody designed for intraocular use, may synergistically promote vascular stability and reduce treatment burden through extended durability in patients with neovascular age-related macular degeneration (nAMD). (arvojournals.org)
  • By restricting oxygen flow to retinal cells, the team went on to discover a protein called angiopoietin-like 4 that, like VEGF, is present at much higher levels in the oxygen-deprived cells. (nih.gov)
  • These results suggest that a drug that could block the action of angiopoietin-like 4 might help prevent proliferative diabetic retinopathy, particularly if combined with VEGF. (nih.gov)
  • Further experiments on the lab-grown human cells revealed that blocking the action of both VEGF and angiopoietin-like 4 markedly reduced blood vessel growth. (nih.gov)
  • Also, it may be useful to measure the levels of angiopoietin-like 4 protein before deciding to treat proliferative diabetic retinopathy with anti-VEGF therapy. (nih.gov)
  • b The MSCs commonly generate and release varied angiogenic mediators surrounding angiopoietin-1 (ANG-1) and IL-6 that, in turn, provoke the release of VEGF and other angiogenic factors stimulating tumor angiogenesis. (biomedcentral.com)
  • MedImmune, LLC and Abpro, collaborated in December 2016 to develop novel bispecific antibody, Ang2-VEGF, which targets angiopoietin-2 and vascular endothelial growth factor. (openpr.com)
  • Two circulating permeability factors, VEGF and Angiopoietin 2 (Ang2), were significantly elevated in episodic SCLS sera. (nih.gov)
  • Our results support a model of SCLS pathogenesis in which canonical permeability mediators such as VEGF and Angiopoietin 2, but not immunoglobulins, transiently activate pathogenic endothelial contraction pathways, suggesting a molecular mechanism and novel potential targets for this highly lethal disorder. (nih.gov)
  • We also have some other exciting things such as OPT-302, which inhibits not only VEGF-A but VEGF-C and -D. That could be a nice compliment to something like faricimab, which inhibits angiopoietin-2, and we will see if other types of VEGF isoform inhibition may allow us to have better outcomes in some of our patients as well. (consultantlive.com)
  • Faricimab also blocks VEGF, but in addition it blocks angiopoietin-2 (Ang-2). (medscape.com)
Ligands2
  • Interesting, studies have shown that, the glioma endothelium expresses high levels of Tie 2 and its ligands, angiopoietins-1 and -2 (Ang-1, -2). (aacrjournals.org)
  • Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. (medlineplus.gov)
ANGPT23
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Angiopoietin 2 (ANGPT2) in samples from serum, plasma or other biological fluids. (bioemm.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Angiopoietin 2 (ANGPT2) in serum, plasma, tissue homogenates and other biological fluids. (bioemm.com)
  • SCF, IL-3, thrombopoietin (Thpo) and angiopoietin-2 (Angpt2) were evaluated with semi-quantitative real-time RT-PCR using mRNA isolated from c-Kit? (bioinf.org)
ELISA4
  • Your search returned 422 Angiopoietin 1 ELISA ELISA Kit across 24 suppliers. (biocompare.com)
  • Description: Quantitativesandwich ELISA kit for measuring Human angiopoietin-like protein 2 (ANGPTL2) in samples from serum, plasma, cell culture supernates, tissue homogenates. (signetlabs.com)
  • The BioAim Human Angiopoietin-1 EasyTest™ ELISA kit can quantitatively measure human Angiopoietin-1 in serum and plasma. (elisa-kits.de)
  • Bovine TEK/Angiopoietin-1 receptor ELISA Kitis available at Gentaur for Next week Delivery. (researchd.com)
ANG22
  • Angiopoietin-2 (ANG2) is a 56.9 kDa glycosylated growth factor that is specific for endothelial cells (ECs) https://www.uniprot.org/uniprot/O35608 ANG2 expressed in embryonic vessels and contributes to the formation of new vasculature. (tecomedical.com)
  • Numerous vasoactive cytokines are upregulated during sepsis, including angiopoietin 2 (ANG2), which increases vascular permeability. (mpg.de)
Endothelial cell3
  • All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. (elisa-kits.de)
  • 2005). Angiopoietins activate TEK in a unique manner, which involves the translocation of TEK to endothelial cell-cell contacts, and TIE1 is also present in these complexes (Saharinen et al. (atlasgeneticsoncology.org)
  • The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. (nih.gov)
Antagonist1
  • A related protein, angiopoietin-2 (ang-2), has been identifiec s a naturally occurring antagonist of Ang-1 avtivation of Tie-2. (researchd.com)
Expression5
  • Changes in expression of vascular endothelial growth factor and angiopoietin-1 and -2 in the macaque corpus luteum during the menstrual cycle. (oregonstate.edu)
  • Using logistic regression analysis, we explored the relationships between plasma angiopoietin-2 levels, parasite VSA expression and the two syndromes of severe malaria, impaired consciousness and respiratory distress. (biomedcentral.com)
  • In contrast, group A-like PfEMP1 expression and angiopoietin-2 maintained independent associations with impaired consciousness when adjusted for each other. (biomedcentral.com)
  • Staton CA, Valluru M, Hoh L, Reed MWR & Brown NJ (2010) Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring. . (sheffield.ac.uk)
  • Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival. (wikidata.org)
Gene2
  • The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. (crcm-marseille.fr)
  • Angiopoietin-1 receptor also known as CD202B ( cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene . (wikidoc.org)
Inhibits1
  • Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases. (drugbank.com)
Soluble1
  • In addition, the early-onset phenotype demonstrated higher plasma levels of soluble receptor for advanced glycation end-products and angiopoietin-2. (nih.gov)
Specificity1
  • Specificity: Natural and recombinant Bovine Angiopoietin-1 receptor GeneName: TEK ProteinName: Angiopoietin-1 receptor Alternative: Endothelial tyrosine. (researchd.com)
Apoptosis1
  • The secondary outcomes were increased vascular permeability (using angiopoietin-2 level), apoptosis (using annexin A5 level), and associated clinical changes. (bvsalud.org)
Peptibody2
  • Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma. (umassmed.edu)
  • Trebananib is an investigational peptibody designed to inhibit the angiopoietin axis. (takeda.com)
Plasma2
  • We used plasma angiopoietin-2 as a marker of widespread endothelial activation. (biomedcentral.com)
  • Plasma angiopoietin-2 was associated with both syndromes. (biomedcentral.com)
Tie11
Protein called1
  • One of these factors was a protein called angiopoietin-like 4. (nih.gov)
Receptors1
  • Farmacologia de receptors NMDAR i funció en mutacions relacionades amb malalties neurològiques. (ub.edu)
Blood vessel1
  • Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting. (nih.gov)
Ciglitazone - Ontology Report - Rat Genome Database
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