Angiopoietins: A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.Angiopoietin-2: An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.Angiopoietin-1: The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.Receptor, TIE-2: A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).Receptor, TIE-1: A TIE receptor found predominantly on ENDOTHELIAL CELLS. It is considered essential for vascular development and can form a heterodimer with the TIE-2 RECEPTOR. The TIE-1 receptor may play a role in regulating BLOOD VESSEL stability and maturation.Receptors, TIE: A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Neovascularization, Physiologic: The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.Angiogenesis Inducing Agents: Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.Vascular Endothelial Growth Factors: A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Endothelial Growth Factors: These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.Receptor Protein-Tyrosine Kinases: A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.Lymphokines: Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Intercellular Signaling Peptides and Proteins: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.Blood Vessels: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Vascular Endothelial Growth Factor Receptor-1: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (1/298)

Using homology-based PCR, we have isolated cDNA encoding a novel member (491 amino acids) of the angiopoietin (Ang) family from human adult heart cDNA and have designated it angiopoietin-3 (Ang3). The NH2-terminal and COOH-terminal portions of Ang-3 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in other known Angs. Ang3 has a highly hydrophobic region at the N-terminus (approximately 21 amino acids) that is typical of a signal sequence for protein secretion. Ang3 mRNA is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine in human adult tissues. Additionally, Ang3 is a secretory protein, but is not a mitogen in endothelial cells.  (+info)

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (2/298)

The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist, angiopoietin-2, both of which act by means of the Tie2 receptor. We now report our attempts to use homology-based cloning approaches to identify new members of the angiopoietin family. These efforts have led to the identification of two new angiopoietins, angiopoietin-3 in mouse and angiopoietin-4 in human; we have also identified several more distantly related sequences that do not seem to be true angiopoietins, in that they do not bind to the Tie receptors. Although angiopoietin-3 and angiopoietin-4 are strikingly more structurally diverged from each other than are the mouse and human versions of angiopoietin-1 and angiopoietin-2, they appear to represent the mouse and human counterparts of the same gene locus, as revealed in our chromosomal localization studies of all of the angiopoietins in mouse and human. The structural divergence of angiopoietin-3 and angiopoietin-4 appears to underlie diverging functions of these counterparts. Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist.  (+info)

Angiopoietin-3, a novel member of the angiopoietin family. (3/298)

A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2.  (+info)

Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. (4/298)

Using degenerate polymerase chain reaction, we isolated a cDNA encoding a novel 493-amino acid protein from human and mouse adult heart cDNAs and have designated it angiopoietin-related protein-2 (ARP2). The NH(2)-terminal and COOH-terminal portions of ARP2 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in angiopoietins. ARP2 has two consensus glycosylation sites and a highly hydrophobic region at the NH(2) terminus that is typical of a secretory signal sequence. Recombinant ARP2 expressed in COS cells is secreted and glycosylated. In human adult tissues, ARP2 mRNA is most abundant in heart, small intestine, spleen, and stomach. In rat embryos, ARP2 mRNA is most abundant in the blood vessels and skeletal muscles. Endothelial and vascular smooth muscle cells also contain ARP2 mRNA. Recombinant ARP2 protein induces sprouting in vascular endothelial cells but does not bind to the Tie1 or Tie2 receptor. These results suggest that ARP2 may exert a function on endothelial cells through autocrine or paracrine action.  (+info)

Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (5/298)

Using degenerate PCR we isolated a cDNA encoding a novel 406- and 410-amino acid protein from human and mouse embryonic cDNAs and have designated it 'hepatic fibrinogen/angiopoietin-related protein' (HFARP). The N-terminal and C-terminal portions of HFARP contain the characteristic coiled-coil domains and fibrinogen-like domains that are conserved in angiopoietins. In human and mouse tissues, HFARP mRNA is specifically expressed in the liver. HFARP mRNA and protein are mainly present in the hepatocytes. HFARP has a highly hydrophobic region at the N-terminus that is typical of a secretory signal sequence and one consensus glycosylation site. Recombinant HFARP expressed in COS-7 cells is secreted and glycosylated. HFARP protein is present not only in the hepatocytes, but also in the circulating blood. Recombinant HFARP acts as an apoptosis survival factor for vascular endothelial cells, but does not bind to Tie1 or Tie2 (endothelial-cell tyrosine kinase receptors). These results suggest that HFARP may exert a protective function on endothelial cells through an endocrine action.  (+info)

Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. (6/298)

The angiopoietins are recently described growth factors for vascular endothelium. The Tie1 and Tie2 receptors are expressed by endothelium. Acquired immune deficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS) and cutaneous angiosarcoma are malignancies of endothelial origin. KS involves primarily the skin and mucosal surfaces and is common in AIDS patients. In an effort to determine whether the angiopoietins and Tie receptors play a role in the pathobiology of angiosarcoma and KS, we studied the expression of angiopoietin-1, angiopoietin-2, angiopoietin-4, Tie1, and Tie2 mRNAs in biopsies of KS from 12 AIDS patients, in biopsies of cutaneous angiosarcoma from two patients, and in control biopsies of normal skin from three volunteers by in situ hybridization. Strong expression of angiopoietin-2, Tie1, and Tie2 mRNAs was detected in the tumor cells of KS and cutaneous angiosarcomas, in contrast to the focal low-level expression in normal skin biopsies. Focal low-level expression of angiopoietin-1 was seen in KS, cutaneous angiosarcomas, and in normal skin. Focal low-level expression of angiopoietin-4 was identified in a minority of KS lesions. These findings suggest that the angiopoietins and Tie receptors may play an important role in the pathobiology of KS and cutaneous angiosarcoma and identify additional potential targets for therapeutic intervention in these vascular malignancies.  (+info)

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. (7/298)

Fasting is associated with significant changes in nutrient metabolism, many of which are governed by transcription factors that regulate the expression of rate-limiting enzymes. One factor that plays an important role in the metabolic response to fasting is the peroxisome proliferator-activated receptor alpha (PPARalpha). To gain more insight into the role of PPARalpha during fasting, and into the regulation of metabolism during fasting in general, a search for unknown PPARalpha target genes was performed. Using subtractive hybridization (SABRE) comparing liver mRNA from wild-type and PPARalpha null mice, we isolated a novel PPARalpha target gene, encoding the secreted protein FIAF (for fasting induced adipose factor), that belongs to the family of fibrinogen/angiopoietin-like proteins. FIAF is predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. Moreover, FIAF mRNA is decreased in white adipose tissue of PPARgamma +/- mice. FIAF protein can be detected in various tissues and in blood plasma, suggesting that FIAF has an endocrine function. Its plasma abundance is increased by fasting and decreased by chronic high fat feeding. The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions.  (+info)

Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (8/298)

The nuclear receptor peroxisome proliferator-activated receptor gamma regulates adipose differentiation and systemic insulin signaling via ligand-dependent transcriptional activation of target genes. However, the identities of the biologically relevant target genes are largely unknown. Here we describe the isolation and characterization of a novel target gene induced by PPARgamma ligands, termed PGAR (for PPARgamma angiopoietin related), which encodes a novel member of the angiopoietin family of secreted proteins. The transcriptional induction of PGAR follows a rapid time course typical of immediate-early genes and occurs in the absence of protein synthesis. The expression of PGAR is predominantly localized to adipose tissues and placenta and is consistently elevated in genetic models of obesity. Hormone-dependent adipocyte differentiation coincides with a dramatic early induction of the PGAR transcript. Alterations in nutrition and leptin administration are found to modulate the PGAR expression in vivo. Taken together, these data suggest a possible role for PGAR in the regulation of systemic lipid metabolism or glucose homeostasis.  (+info)

*Vascular endothelial growth factor A

"Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy". ...

*Angiopoietin-related protein 2

Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted ... Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 ... and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J Biol ... Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific ...

*Angiopoietin

... -1 and angiopoietin-2 can form dimers, trimers, and tetramers. Angiopoietin-1 has the ability to form higher order ... is demonstrated by an increased ratio of angiopoietin-2 and angiopoietin-1 in blood serum. To be specific, angiopoietin levels ... Angiopoietin-1 encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa whereas angiopoietin-2 encodes a 496 ... Angiopoietin-2 is elevated in patients with angiosarcoma. Research has shown angiopoietin signaling to be relevant in treating ...

*Angiopoietin 1

... is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in ... increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta. This suggests that ... Dunk C, Shams M, Nijjar S (2000). "Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration ... Cheung AH, Stewart RJ, Marsden PA (1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): ...

*Angiopoietin receptor

The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind ... The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis). The angiopoietins are ... In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4). Ang1 and ... But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.[citation ...

*Angiopoietin-like proteins

The Angiopoietin-like proteins are proteins structurally like the angiopoietins but which do not bind to the angiopoietin ... Angiopoietin-related protein 1, gene ANGPTL1 Angiopoietin-related protein 2, gene ANGPTL2 Angiopoietin-related protein 3, gene ... Angiopoietin-related protein 7, gene ANGPTL7 Angiopoietin-related protein 8, gene ANGPTL8, also known as lipasin because of its ... gene ANGPTL4 Angiopoietin-related protein 5, gene ANGPTL5, mainly expressed in adult human heart. Angiopoietin-related protein ...

*Angiopoietin-related protein 7

... is a protein that in humans is encoded by the ANGPTL7 gene. It is one of the 8 angiopoietin-like ... "Entrez Gene: ANGPTL7 angiopoietin-like 7". Angiopoietin-like proteins: a comprehensive look Shau H, Butterfield LH, Chiu R, Kim ... Peek R, Kammerer RA, Frank S, Otte-Holler I, Westphal JR (Jan 2002). "The angiopoietin-like factor cornea-derived transcript 6 ...

*Angiopoietin-related protein 1

Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this ... Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein ...

*Hes3 signaling axis

Activation of the Tie2 receptor by the ligand Angiopoietin 2. This has been shown in vitro and in vivo. Activation of the ... Activation of the signaling pathway by Delta4, Angiopoietin 2, insulin, or a combination of the three and a JAK inhibitor ... Angiopoietin 2). Hes3, in turn, by regulating the expression of Shh and potentially other factors, can also exert an effect on ... Angiopoietin 2, insulin, or a combined treatment consisting of all three factors and an inhibitor of JAK) induce the increase ...

*ANGPT4

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene. Angiopoietins are proteins with important roles in ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3-4): 147-54. ... "Entrez Gene: ANGPT4 angiopoietin 4". Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser. ...

*ANGPTL4

"Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 ... Li L, Chong HC, Ng SY, Kwok KW, Teo Z, Tan EH, Choo CC, Seet JE, Choi HW, Buist ML, Chow VT, Tan NS (2015). "Angiopoietin-like ... Xu A, Lam MC, Chan KW, Wang Y, Zhang J, Hoo RL, Xu JY, Chen B, Chow WS, Tso AW, Lam KS (2005). "Angiopoietin-like protein 4 ... Chong HC, Chan JS, Goh CQ, Gounko NV, Luo B, Wang X, Foo S, Wong MT, Choong C, Kersten S, Tan NS (2014). "Angiopoietin-like 4 ...

*ANGPTL3

Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene. The protein encoded by ... The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced ... 2003). "Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes". Biochem. Biophys. Res. ... 2003). "Regulation of the angiopoietin-like protein 3 gene by LXR". J. Lipid Res. 44 (1): 136-43. doi:10.1194/jlr.M200367- ...

*Nesvacumab

It targets the protein angiopoietin 2. As of May 2017[update], it is in Phase II clinical trials for the treatment of diabetic ... "Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of ...

*TEK tyrosine kinase

"Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization". Circulation Research. 83 (3): 233-40. ... Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the ... Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (Nov 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent ...

*ANGPT2

Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 ... Xu Y, Yu Q (September 2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its ... "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... similar to angiopoietin-1 See Angiopoietin#Clinical_relevance ANGPT2 has been shown to interact with TEK tyrosine kinase. ...

*Angiogenesis

The angiopoietins, Ang1 and Ang2, are required for the formation of mature blood vessels, as demonstrated by mouse knock out ... Thurston G (October 2003). "Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis". ...

*Epithelial-mesenchymal transition

Li, J. J.; Huang, Y. Q.; Basch, R.; Karpatkin, S. (February 2001). "Thrombin induces the release of angiopoietin-1 from ... Angiopoietin-1) and cytokines including the EMT inducer TGF-β. The release of TGF-β by platelets in blood vessels near primary ...

*Pericyte

Also, angiopoietin 2 can act as an antagonist to Tie-2. This destabilizes the endothelial cells, which accounts for less ... Angiopoietin 1 and Tie-2 signaling is essential for maturation and stabilization of endothelial cells. Platelet-derived growth ... Similar to the inhibition of the PDGF pathway, angiopoietin 2 reduces levels of pericytes, leading to diabetic retinopathy. ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...

*N-Acetylmannosamine

Chugh, S; Macé, C; Clement, L; Del Nogal, A; Marshall, C (2014). "Angiopoietin-like 4 based therapeutics for proteinuria and ...

*Thomas N. Sato

... and angiopoietins, that play the key roles in the blood vessel formation. "Laboratory of Biodynamics and Integrative Biology". ... "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis". Cell. 87 (7): 1171-1180. doi: ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...

*FCN3

Zeng L, Dai J, Ying K (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet ...

*GRLF1

Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). "Angiopoietin-1 ...

*Subdural hematoma

Mediators that promote angiogenesis are: angiopoietin and vascular endothelial growth factor (VEGF). Meanwhile, prostaglandin ...

*Vascular endothelial growth factor

The expression of angiopoietin-2 in the absence of VEGF leads to endothelial cell death and vascular regression. Conversely, a ... Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in ...

*FCN1

2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159-62. doi: ...
Looking for online definition of angiopoietin-related protein 3 in the Medical Dictionary? angiopoietin-related protein 3 explanation free. What is angiopoietin-related protein 3? Meaning of angiopoietin-related protein 3 medical term. What does angiopoietin-related protein 3 mean?
Looking for online definition of angiopoietin-related protein 5 in the Medical Dictionary? angiopoietin-related protein 5 explanation free. What is angiopoietin-related protein 5? Meaning of angiopoietin-related protein 5 medical term. What does angiopoietin-related protein 5 mean?
Angiopoietin-like Protein 1/ANGPTL1 Proteins available through Novus Biologicals. Browse our Angiopoietin-like Protein 1/ANGPTL1 Protein catalog backed by our Guarantee+.
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Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene. Angiopoietin-like protein 2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas an excess of ANGPTL2 activation induced by prolonged stress promotes the breakdown of tissue homeostasis due to chronic inflammation, promoting the development of metabolic diseases. ANGPTL2 has a role also in angiogenesis, in tissue repair, in obesity, in atherosclerotic diseases and finally in cancerogenesis. Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. GRCh38: ...
Lipoprotein lipase (LPL) hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue. LPL in macrophages in the artery wall may, however, promote foam cell formation and atherosclerosis. Angiopoietin-like protein (ANGPTL) 4 inactivates LPL and ANGPTL4 expression is controlled by peroxisome proliferator-activated receptors (PPAR). The mechanisms for inactivation of LPL by ANGPTL4 was studied in THP-1 macrophages where active LPL is associated with cell surfaces in a heparin-releasable form, while LPL in the culture medium is mostly inactive. The PPAR delta agonist GW501516 had no effect on LPL mRNA, but increased ANGPTL4 mRNA and caused a marked reduction of the heparin-releasable LPL activity concomitantly with accumulation of inactive, monomeric LPL in the medium. Intracellular ANGPTL4 was monomeric, while dimers and tetramers of ANGPTL4 were present in the heparin-releasable fraction and medium. GW501516 caused an increase ...
Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA expression of the anti-apoptotic BCL-2 family
Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin β1 signaling in human hepatocellular ...
Chronic vascular inflammation in coronary artery plays crucial roles in pathogenesis of coronary artery disease (CAD) through causing endothelial dysfunction and the progression of coronary atherosclerosis. Recently, we reported that adipose tissue-derived Angptl2 is a key mediator linking obesity to adipose tissue inflammation and systemic insulin resistance (Cell Metabolism 2009). Since angptl2 is also secreted from endothelial cells, and promotes vascular inflammation via the integrin α5β1/Rac1/NF-κB pathway, we investigated whether Angptl2 cause the coronary endothelial dysfunction and atherosclerosis in CAD. First, we compared circulating Angptl2 levels in 83 subjects with coronary endothelial dysfunction (CED) and 30 subjects with chest pain syndrome (CPS) of normal coronary endothelial function. We assessed coronary endothelial function by estimating the ratio of coronary blood flow in response to intracoronary injection of acetylcholine (ACh). Plasma Angptl2 concentrations were ...
Sigma-Aldrich offers abstracts and full-text articles by [Dana Mahmood, Elena Makoveichuk, Solveig Nilsson, Gunilla Olivecrona, Bernd Stegmayr].
Effective slimming actives should reduce lipogenesis, increase lipolysis, promote fatty acid release and improve skin firmness. Here, the authors describe the development of such an active based on polyglucuronic acid. Further, this material is shown to act on a new biological pathway involving the fasting-induced adipose factor (FIAF) adipokine.
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Purpose: : Angiopoietin-like proteins 2 (Angptl2) is closely related to inflammation via NFΚB signaling in diabetes, and also promotes angiogenesis and vascular leakiness in vivo. We previously reported Angptl2 concentration in vitreous and serum was increased and expressed in fibrovascular membrane in diabetic patients. However, the function of Angptl2 in diabetic retinopathy is still unknown. In this study, we investigated the effect of Angptl2 using Angptl2 knockout mice feeding western-style high-fat diet. Methods: : Angptl2 knockout and wild type mice were fed a high-fat diet for 2 months. We extracted protein from retinas of those mice and measured the concentration of intercellular adhesion molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and IL-6 using sandwich enzyme-linked immunosorbent assay (ELISA). Moreover, the retinal vasculature and adherent leukocytes were stained by perfusion labeling with fluorescein isothiocyanate ...
Objective: Lipoprotein lipase (LPL) is a key regulator of circulating triglyceride rich lipoprotein hydrolysis. In brain LPL regulates appetite and energy expenditure. Angiopoietin-like 4 (Angptl4) is a secreted protein that inhibits LPL activity and, thereby, triglyceride metabolism, but the impact of Angptl4 on central lipid metabolism is unknown. Methods: We induced type 1 diabetes by streptozotocin (STZ) in whole-body Angptl4 knockout mice (Angptl4-/-) and their wildtype littermates to study the role of Angptl4 in central lipid metabolism. Results: In type 1 (streptozotocin, STZ) and type 2 (ob/ob) diabetic mice, there is a ~2-fold increase of Angptl4 in the hypothalamus and skeletal muscle. Intracerebroventricular insulin injection into STZ mice at levels which have no effect on plasma glucose restores Angptl4 expression in hypothalamus. Isolation of cells from the brain reveals that Angptl4 is produced in glia, whereas LPL is present in both glia and neurons. Consistent with the in vivo ...
The ANGPTL4 Human Recombinant is manufactured with C-terminal fusion of 11 amino acid FLAG Tag. The ANGPTL4 Flag -Tagged Fusion Protein is a 44.2kDa protein containing 392 amino acid residues of the Angiopoietin-like Protein 4 and 11 additional amin
Model of tumor cell resistance to antineoplastic therapy through angiopoietin-like protein 2 (ANGPTL2) expression. Tumor cell-secreted ANGPTL2 induces spleen ty
UNLABELLED: Myeloid cells are known to mediate metastatic progression. Here, we attempted to elucidate the mechanisms underlying these effects by identifying gene expression alterations in cancer cells forming hepatic metastases after myeloid cell depletion. Hepatic metastases are heavily infiltrated by CD11b(+) myeloid cells. We established hepatic metastases in transgenic CD11b-diphtheria toxin receptor mice by intrasplenic injection of MC38 colon and Lewis lung carcinoma cells before depleting myeloid cells with diphtheria toxin. Myeloid cell depletion inhibited metastatic growth with a marked diminishment of tumor vasculature. Expression of ANGPTL7 (angiopoietin-like 7), a protein not previously linked to metastasis, was highly up-regulated in cancer cells after myeloid cell depletion. This effect was duplicated in tissue culture, where coculture of cancer cells with tumor-conditioned myeloid cells from liver metastases or myeloid cell conditioned media down-regulated ANGPTL7 expression. Analogous
Creative Bioarray produces the worlds most comprehensive list of research-use cells, including tumor cells, primary cells, stem cells AND transformed cells. Creative Bioarray offers ActoFactor™ Recombinant Human Angiopoietin-like 3 for your research.
The majority of patients with diabetic macular edema (DME), the most common cause of vision loss in working-age Americans, do not respond adequately to current therapies targeting VEGFA. Here, we show that expression of angiopoietin-like 4 (ANGPTL4), a HIF-1-regulated gene product, is increased in the eyes of diabetic mice and patients with DME. We observed that ANGPTL4 and VEGF act synergistically to destabilize the retinal vascular barrier. Interestingly, while ANGPTL4 modestly enhanced tyrosine phosphorylation of VEGF receptor 2, promotion of vascular permeability by ANGPTL4 was independent of this receptor. Instead, we found that ANGPTL4 binds directly to neuropilin 1 (NRP1) and NRP2 on endothelial cells (ECs), leading to rapid activation of the RhoA/ROCK signaling pathway and breakdown of EC-EC junctions. Treatment with a soluble fragment of NRP1 (sNRP1) prevented ANGPTL4 from binding to NRP1 and blocked ANGPTL4-induced activation of RhoA as well as EC permeability in vitro and retinal ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
ANGPTL4 - ANGPTL4 (Myc-DDK-tagged)-Human angiopoietin-like 4 (ANGPTL4), transcript variant 3 available for purchase from OriGene - Your Gene Company.
Angptl4 - Angptl4 (Myc-DDK-tagged ORF) - Rat angiopoietin-like 4 (Angptl4), (10 ug) available for purchase from OriGene - Your Gene Company.
Author Summary Recent studies have revealed that the community of microorganisms residing in the intestine regulates fat storage. Microbes evoke this response in part by suppressing expression of the Angptl4 gene, which encodes a secreted inhibitor of fat storage. Although Angptl4 is expressed in multiple tissues, microbial suppression occurs only in the intestine. To determine how microbes control fat storage, we must elucidate the mechanisms underlying intestine-specific and microbial regulation of Angptl4 expression. Here, we take advantage of the unique features of the zebrafish model to define the regulatory DNA sequences controlling angptl4 expression. Our results reveal that different DNA regulatory regions within the angptl4 gene mediate expression of angptl4 in the intestine and other tissues. By assessing the evolution of angptl4 regulatory regions and subjecting them to structure-function analyses, we identify discrete DNA sequences that are required for intestinal expression. Strikingly,
The angiopoietin-like 4 (ANGPLT4) protein is involved in lipid metabolism and is known to inhibit lipoprotein lipase in the bloodstream. We investigated the effect of milk on intestinal ANGPTL4 and the metabolic profile of growing pigs and the effect of free fatty acids (FFAs) on ANGPTL4 in ex vivo and in vitro assays. Feeding pigs whole milk increased intestinal ANGPTL4 mRNA and increased fecal excretion of long-chain FFA compared to the control group fed soybean oil (n = 9). Furthermore, FFAs (C4-C8) induced ANGPTL4 gene expression in porcine intestinal tissue mounted in Ussing chambers and ANGPTL4 protein secretion to both the apical and basolateral sides of intestinal Caco-2 cells on permeable membranes ...
3006 Angiopoietin Related Proteins (ARPs) play a pivotal role in vascular formation and homeostasis. ARP4, a secreted protein, retains the characteristic angiopoietin family N-terminal coiled-coil domain and C-terminal fibrinogen-like domain. RTQ PCR analysis revealed transcript expression predominantly in adipose and liver tissues. Strikingly, ARP4 mRNA expression is also elevated in clear cell renal carcinoma as compared to adjacent non-tumor tissue suggesting a role in the neovascularization and progression of this disease. Our results confirm and extend the proposed role of ARP4 in the angiogenesis and progression of renal carcinoma. In this study, we report the biological characterization of purified recombinant ARP4 and that it acts both as a proangiogenic factor for endothelial cells and as a survival factor for 786-0 renal carcinoma cells. Based on these observations, we hypothesized that a monoclonal antibody raised against ARP4 might inhibit ARP4-induced activities and be useful in the ...
Rabbit polyclonal antibody raised against a full-length human ANGPTL3 protein. ANGPTL3 (NP_055310.1, 1 a.a. ~ 460 a.a) full-length human protein. (H00027329-D01P) - Products - Abnova
Targeting the blood-vessel-growth protein angiopoietin-like 4 (ANGPTL4) along with anti-vascular endothelial growth factor (VEGF) therapy could increase the effectiveness of treatments for the prevention of proliferative diabetic retinopathy (PDR), according to researchers at The Johns Hopkins University and the University of Maryland.
Human ANGPTL3 partial ORF ( NP_055310.1, 361 a.a. - 460 a.a.) recombinant protein with GST-tag at N-terminal. (H00027329-Q01) - Products - Abnova
La dérégulation de la formation et lintégrité des vaisseaux sanguins peut conduire à un état pathologique tel quobservé dans de nombreuses maladies ischémiques telles que: la croissance de tumeur solide, larthrite rhumatoïde, le psoriasis, les rétinopathies et lathérosclérose. Par conséquent, la possibilité de moduler langiogenèse régionale chez les patients souffrant dischémie est cliniquement pertinente. Un élément clé dans linduction de langiogenèse pathologique est une inflammation qui précède et accompagne la formation des nouveaux vaisseaux. Ce phénomène est démontré par laugmentation de la perméabilité vasculaire et le recrutement de monocytes/ macrophages et cellules polynucléaires (neutrophiles). En collaboration avec dautres groupes, nous avons montré que différents facteurs de croissance tels que le facteur de croissance endothélial vasculaire et les angiopoïétines peuvent non seulement promouvoir langiogenèse mais aussi induire diverses ...
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The siRNA ARO-ANG3 directed at ANGPTL3 gave durable lowering of ANGPTL3, TG, VLDL-c, LDL-c and HDL-c up to 16 weeks after a single dose, with a good safety profile.
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Complete information for ANGPTL2 gene (Protein Coding), Angiopoietin Like 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
购买我们的重组人ANGPTL3蛋白。Ab109135为有活性的全长蛋白,在HEK 293细胞中生产并经过Functional Studies, SDS-PAGE实验验证。中国80%以上现货。
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Looking for online definition of angiopoietin-like factor in the Medical Dictionary? angiopoietin-like factor explanation free. What is angiopoietin-like factor? Meaning of angiopoietin-like factor medical term. What does angiopoietin-like factor mean?
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor. Since differentiation can attenuate or halt the growth of tumor cells, an image-based phenotypic screening was performed to find out drugs inducing morphological differentiation of GBMs. Bexarotene, a selective retinoid X receptor agonist, showed strong inhibition of neurospheroidal colony formation and migration of cultured primary GBM cells. Bexarotene treatment reduced nestin expression, while significantly increasing glial fibrillary acidic protein (GFAP) expression. The effect of bexarotene on gene expression profile was compared with the activity of all-trans retinoic acid (ATRA), a well-known differentiation inducer. Both drugs largely altered the gene expression pattern into a tumor-ameliorating direction. These drugs increased the gene expression levels of Kruppel-like factor 9 (KLF9), regulator of G-protein signaling 4 (RGS4), growth differentiation factor 15 (GDF15), angiopoietin-like protein 4 (ANGPTL4), and ...
Angiogenesis is a complex multistep process by which new blood vessels are formed from the preexisting vasculature.1 2 Angiogenesis is a crucial event in normal embryonic development, and it contributes to the development and progression of a number of diseases, including cancer, arthritis, and diabetes. Conversely, insufficient growth of collateral vessels is a major clinical problem in atherosclerotic cardiovascular disease. The involvement of angiogenesis, or the failure of angiogenesis, in these important diseases has created a tremendous effort to define the molecular mechanisms by which the process is driven.. Until recently, most of the work in the field has focused on polypeptide growth factors, such as fibroblast growth factor and vascular endothelial growth factor (VEGF), which are mitogenic for endothelial cells in vitro and produce an angiogenic response in vivo. Angiopoietins (Ang1 and Ang2) constitute a novel family of endothelial growth factors that are ligands for the ...
Detect and quantitate human angiopoietin-like 3 protein (ANGPTL3) in buffered solution and cell culture supernatants using a homogeneous LANCE Ultra TR-FRET assay.
Detect and quantitate human angiopoietin-like 3 protein (ANGPTL3) in buffered solution and cell culture supernatants using a homogeneous LANCE Ultra TR-FRET assay.
A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY ...
Expression of ANGPTL2 (ARP2, HARP) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
ANGPTL7 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 324 amino acids (22-337 a.a.) and having a molecular mass of 37.5kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).
The International Federation of Film Archives (FIAF) brings together institutions dedicated to rescuing of films both as art and as historical documents
The International Federation of Film Archives (FIAF) brings together institutions dedicated to rescuing of films both as art and as historical documents
The International Federation of Film Archives (FIAF) brings together institutions dedicated to rescuing of films both as art and as historical documents
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It has been reported that Angptl3 can, at least in vitro, act as an inhibitor of LPL,11 HL,19 and EL,12 3 enzymes that are involved in the lipolytic degradation of VLDL and HDL particles. It has, therefore, been proposed that the FHBL2 phenotype caused by the deficiency of Angptl3 could result from dysfunction of 1 or several of these lipolytic enzymes.5. Taking advantage of cohorts of homozygote and heterozygote carriers of the LOF mutation S17X in the ANGPTL3 gene who display either complete or partial absence of Angptl3 protein in the circulation,3 we tested whether the FHBL2 phenotype could be caused by changes in lipase activities of LPL, HL, or EL.. A major finding in the study was that homozygote carriers of the S17X mutation demonstrated a marked increase in LPL activity in postheparin plasma. This is in full agreement with previous work by Koster et al10 demonstrating that postheparin plasma (PHP)-LPL activity was ≈9-fold higher in male Angptl3-deficient mice, compared with male ...
Abbreviations: ABC, ATP-binding cassette transporter; ANGPTL3, angiopoietin-like 3; apo, apolipoprotein; ARL7, ADP-ribosylation factor-like 7; CAD, coronary artery disease; CXCR4, CXC receptor 4; EC, endothelial cell; FOXA2, forkhead box A2; GPAM, glycerol-3-phosphate acyltransferase 1; HDL, high-density lipoprotein; HDL-C, HDL-cholesterol; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase; IL, interleukin; LDL, low-density lipoprotein; LDLR, LDL receptor; LNA, locked nucleic acid; LOX-1, oxidized LDL receptor 1; LPL, lipoprotein lipase; LPS, lipopolysaccharide; LXR, liver X receptor; Mct1, monocarboxylate transporter 1; MI, myocardial infarction; miRNA, microRNA; Mtpn, myotrophin; NFAT, nuclear factor of activated T-cells; NF-κB, nuclear factor κB; p27Kip1, cyclin-dependent kinase inhibitor 1B; p57Kip2, cyclin-dependent kinase inhibitor 1C; oxLDL, oxidized LDL; PEPCK, phosphoenolpyruvate carboxykinase; PI3K, phosphoinositide 3-kinase; PPAR, peroxisome proliferator-activated receptor; pre-miRNA, ...
Regeneron and Ionis each have publications in The New England Journal of Medicine aimed at a brand new cardio target ANGPTL3. The New York Times chronicles the story, which begins in 1994 when a woman in St. Louis gave a blood sample at an employer-sponsored health fair. Regeneron is working on a monoclonal antibody which they say has reduced atherosclerotic lesions in mice and lowered triglycerides and LDL in humans. Ionis is going after the same target using an antisense oligonucleotide targeting Angptl3 messenger RNA. They say they observed dose-dependent reductions in triglycerides and LDL, slowing of atherosclerosis progression and an increase in insulin sensitivity in mice that received the compound. Human participants who received weekly injections of the oligonucleotide had triglyceride reductions ranging from 33% to 63%, LDL reductions ranging from 1% to 33%, VLDL reductions of 28%-60%, and non-HDL level reductions of 10% to 36.6%.. → Taiwans Aslan Pharmaceuticals raised $33 million ...
Six thousand participants, 200 published papers, two genes associated with fatty liver disease discovered, one breakthrough drug class - those impressive numbers add up to the Dallas Heart Study, a landmark investigation begun at UTSW 15 years ago.
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Angiopoietin 1 and Angiopoietin 2 are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie 2. Angiopoietin 2 is only 60% homologous with Angiopoietin 1. Angiopoietin-2 is a naturally occurring antagonist of angiopoietin-1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation. Angiopoietin 1 binding to Tie 2 causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus. ...
A growing population of patients who have exhausted current interventional and surgical approaches to treat coronary malperfusion depend on novel therapeutic approaches. One strategy potentially meeting the needs of the "no option" patient consists of therapeutic neovascularization via growth factors such as the vascular endothelial growth factor (VEGF), fibroblast growth factor, insulin-like growth factor (IGF), angiopoietin families among others. Earlier clinical studies using growth factor treatment of the ischemic region yielded mixed results, with singular studies improving the record by using advanced regional delivery (1,2) and vector (3) systems. The concept of therapeutic neovascularization requires angiogenesis (4), defined as capillary sprouting, as well as arteriogenesis (5,6) (e.g., enlargement of preexisting conductance vessels for improvement of tissue perfusion). Recent studies found a contribution of vasculogenesis (7,8)-using endothelial progenitor cells-to vessel growth in the ...
Gene Information The ficolin family of proteins are characterized by the presence of a leader peptide a short N-terminal segment followed by a collagen-like region and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q C-type lectins known as collectins and tenascins. However all these proteins recognize different targets and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq Jul 2008]. ...
OBJECTIVES: Tie2 and its ligands, the angiopoietins (Ang), are required for embryonic and postnatal angiogenesis. Previous studies have demonstrated that Tie2 is proteolytically cleaved from endothelial cells and produces a 75 kDa soluble receptor fragment (sTie2), however, the signaling mechanisms and effector molecules responsible for the shedding phenomenon are unknown. We investigated mechanisms responsible for Tie2 shedding.. MATERIALS: Human umbilical vein endothelial cells (HUVECs), NIH-3T3, or HEK293 cells exogenously expressing full-length Tie2 were serum starved for varying timepoints. The conditioned media (CM) were then analyzed for the presence of Tie2 by ELISA or westernblot using a Tie2-specific antibody recognizing the extracellular domain. VEGF-A165 (R&D systems) was used for experimentation. Pharmacologic inhibitors of p38 MAPK, Akt, and PI3K were also used. Adenovirus encoding myristylated Akt, wildtype PTEN, dominant negative PTEN and catalytically inactive PTEN were used to ...
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Safety and tolerability of single and multiple doses of IONIS ANGPTL3-LRx (incidence, severity, and dose-relationship of adverse effects and changes in the laboratory parameters ...
Angiopoietin 1兔多克隆抗体(ab94684)可与小鼠, 人样本反应并经WB, IHC实验严格验证并得到1个独立的用户反馈。所有产品均提供质保服务,中国75%以上现货。
Published data on the role of the Ang/tie-2 system in cardiovascular diseases are limited. Most of our knowledge regarding the angiopoietins has come from oncology studies where angiogenesis is a prerequisite for tumor growth and metastasis. Indeed, Ang-2 has been shown to be a marker of a poor prognosis in breast cancer and non-small cell lung cancer (4,21). In the present paper, we describe a new assay for Ang-1 and, in addition, have demonstrated (for the first time in the literature) very abnormal levels of Ang-2 and tie-2, but normal Ang-1, in CHF. Vascular endothelial growth factor was marginally raised in the patients, suggesting that Ang-2 may be more relevant to the pathophysiology of this disease. In addition, there was a significant correlation between Ang-2 and tie-2.. That Ang-1 is not raised in CHF is consistent with currently held views that its secretion is not stimulated by hypoxia, as demonstrated in animal studies (13,14,22). Angiopoietin-1 has been shown to have antiapoptotic ...
Buy our Recombinant human Angiopoietin 1 protein. Ab69492 is an active full length protein produced in HeLa cells and has been validated in FuncS, SDS-PAGE…
Camenisch G et al. (2002) ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.. [^] ...
Sigma-Aldrich offers abstracts and full-text articles by [Tsuyoshi Inoue, Takahide Kohro, Toshiya Tanaka, Yasuharu Kanki, Guoliang Li, Huay-Mei Poh, Imari Mimura, Mika Kobayashi, Akashi Taguchi, Takashi Maejima, Jun-ichi Suehiro, Akira Sugiyama, Kiyomi Kaneki, Hirofumi Aruga, Shoulian Dong, Junko F Stevens, Shogo Yamamoto, Shuichi Tsutsumi, Toshiro Fujita, Xiaoan Ruan, Hiroyuki Aburatani, Masaomi Nangaku, Yijun Ruan, Tatsuhiko Kodama, Youichiro Wada].
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Catalytic domain of the Protein Tyrosine Kinase, Tie2. Protein Tyrosine Kinase (PTK) family; Tie2; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie2 is a receptor tyr kinase (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie2 is expressed mainly in endothelial cells and hematopoietic stem cells. It is also found in a subset of tumor-associated monocytes and eosinophils. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2. The binding of Ang-1 to Tie2 leads to ...
The present results show a switch in the expression of factors involved in vascular destabilization and angiogenic activation at the superficial and noninvasive stage of bladder cancer. Briefly, we show here that (a) the Ang-1 expression is dramatically reduced in tumor stage Ta in comparison with normal bladder epithelium; (b) in contrast, the highest level of Ang-2 and VEGF expression is measured in this tumor stage; (c) high level of Ang-2 expression seems to be a strong independent predictor of tumor recurrence; and (d) enhanced expression of Tie2 is identified as an independent favorable prognostic factor of disease-specific survival. Particularly, the reduced expression of Ang-1 accompanied by enhanced expression of Ang-2 and VEGF in bladder cancer stage Ta in comparison with normal bladder epithelium suggests an establishment of a potent proangiogenic stimulus at the superficial bladder cancer stage Ta.. Angiopoietins represent a family of extracellular ligands of the tyrosine kinase ...
Angiopoietins (Ang) are vascular endothelial cell-specific growth factors that play important roles principally during the later stages of angiogenesis. We have compared the distribution of the...
HOUSTON-Colon cancer researchers are studying a variety of cell surface molecules and receptors as potential targets for new treatments aimed particularly at preventing or treating metastatic disease. Lee Ellis, MD, professor of surgery and cancer biology at the University of Texas M. D. Anderson Cancer Center in Houston, discussed his groups current work in three new areas: angiopoietins as a target for blocking tumor angiogenesis, integrins, and the insulin growth factor-1 (IGF-1) system. 1
Angiopoietin 2 antibody (angiopoietin 2) for ELISA, IHC-P, WB. Anti-Angiopoietin 2 pAb (GTX10601) is tested in Human samples. 100% Ab-Assurance.
Polyclonal antibody for Angiopoietin 2/ANGPT2 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. Angiopoietin 2/ANGPT2 information: Molecular Weight: 56919 MW; Subcellular Localization: Secreted.
Angiopoietins are a family of growth factors that are ligands for the tyrosine kinase receptor, Tie2. Angiopoietin 1 (Ang-1) is agonistic for Tie2, plays a key role in blood vessel maturation and stability and has been shown to possess anti-inflammatory properties. However, Tie2 expression has been demonstrated on human neutrophils and the observation that neutrophils migrate in response to Ang-1 in vitro has confounded research into its exact role in inflammation as well as its potential use as a therapeutic agent. We used a mouse model of peritoneal neutrophilic inflammation to determine if Ang-1 could stimulate neutrophil migration in vivo. Tie2 expression was demonstrated on mouse neutrophils. In addition, recombinant human Ang-1 induced significant chemotaxis of isolated mouse neutrophils in a Tie2- and CD18-dependent manner. Subsequently, co-immunoprecipitation of Ang-1 and CD18 demonstrated their interaction. Intraperitoneal injection of an engineered angiopoietin-1, MAT.Ang-1, induced ...
Genomic abnormalities lead to aberrant cell growth and signalling, contributing to the development of malignancy. Growth and metastasis also require the development of tumour vasculature. The VEGFs and angiopoietins are growth factor families central to this process. This thesis examines their expression in endometrial cancer. Genomic and post-genomic studies are used to broaden the investigation of angiogenesis and include related pathways. Using in situ hybridisation VEGF-A mRNA was detected in epithelial cancer cells but not pre-malignant and benign endometrium while VEGF-B was localised to both epithelial and stromal cells and was most abundant in benign endometrium. These findings suggest that VEGF-B may modulate the actions of VEGF-A by occupying receptors. Larger, gene microarray studies confirmed the differential expression of angiogenic factors and also identified a distinct set of coherently regulated genes in endometrial cancers. Within this gene set, PPARα, a transcription factor ...
FCN2 Full-Length MS Protein Standard (NP_056652), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.
The angiopoietin/Tie (ANG/Tie) receptor system controls developmental and tumor angiogenesis, inflammatory vascular remodeling, and vessel leakage. ANG1 is a Tie2 agonist that promotes vascular stabilization in inflammation and sepsis, whereas ANG2 is a context-dependent Tie2 agonist or antagonist. A limited understanding of ANG signaling mechanisms and the orphan receptor Tie1 has hindered development of ANG/Tie-targeted therapeutics. Here, we determined that both ANG1 and ANG2 binding to Tie2 increases Tie1-Tie2 interactions in a β1 integrin-dependent manner and that Tie1 regulates ANG-induced Tie2 trafficking in endothelial cells. Endothelial Tie1 was essential for the agonist activity of ANG1 and autocrine ANG2. Deletion of endothelial ...
There has been little work on the regulation of adipose tissue angiogenesis in obese subjects, although evidence implicates angiogenesis in the development of adipose tissue. Our study shows that adipose tissue from obese adult subjects grafted on CAM was able to induce angiogenesis with recruitment of vascular cells of both human and host (avian) origin. Although the expression of several angiogenic genes differed slightly between SAT and VAT, the expression of the main angiogenic factors, and notably VEGF, was similar in SAT and VAT. SAT and VAT also had similar angiogenic potencies on CAM, and inhibition of VEGF strongly inhibited angiogenesis in both tissues.. Adipose tissue is highly vascularized (2,3,5,9), and many angiogenic factors are secreted by adipose tissue, including VEGF, hepatocyte growth factor, placental growth factor (PlGF), angiopoietins, FGFs, TNF-α, PAI-1, and metalloproteases (2,8,9,18,32,33). Adipose tissue contains mature adipocytes and many other cell types known as ...
Ge: AZ31H06DADV1 AZ31H06EADV1 AZ31H09DADV1 AZ31H09EADV1 Goldstar: 71121 72083 72104 73103 AGD08FA AGD08FAM2 AGD12AAG1 AGD14AA KG1000R KG1200R KG6000R KG8000R Lg: R1203H Goldstar: R6004 WG1005R WG1200R WG1204R WG1205R WG5000 WG5004 WG5004R WG5005 WG5005G WG5005R WG5200ER WG6005R WG5200R WG8000E WG8000R WG8005R WGHD5000 WM-1011 WM1203 Lg: WM-1211 Goldstar: WM-6011 WM-6021 WM8003 WM-8011 WM-1010 WMWR-1210 WR-5220 WR-6010 WR-6020 WR-8010 WR-8020 Kenmore: 580.72087 200 580.73083 300 580.73093 300 580.73104 300 580.74103 300 580.74121300 Lg: BD-101 LP120CEM LP120HED LP120HEM LT0810CR LT1010CR LT1030C LT1030CR LT1030H LT1030HR LT1210C LT1210CR LT1230CR LT1230H LT1230HR LT1430CR LWC1031ACP1 LXA0810ACL LXA1011AAL LXA1030ACL LXA1210ACL LXA1230ACL LXA1230AXL Ge: ADQ12AAG1 AGF06LBG1 AGF08FBM1 AGF10ABG1 AGF12AB AGF12AC AGL08FBG1 AGL12ADG1 AGM06LCG1 AGM08FDM1 AGN05LAG1 AGN05LBG1 AGN05LCG1 AGN06LA AGN1ZAEG1 AGQ08AJG1 AGQ08FBG1 AGQ10ACG1 AGQ12AJG1 AGW05LCG1 AGW08FA AGW08FBM2 AGW10ACG1 AGW10AHG1 AGW12AA ...
Ge: AZ31H06DADV1 AZ31H06EADV1 AZ31H09DADV1 AZ31H09EADV1 Goldstar: 71121 72083 72104 73103 AGD08FA AGD08FAM2 AGD12AAG1 AGD14AA KG1000R KG1200R KG6000R KG8000R Lg: R1203H Goldstar: R6004 WG1005R WG1200R WG1204R WG1205R WG5000 WG5004 WG5004R WG5005 WG5005G WG5005R WG5200ER WG6005R WG5200R WG8000E WG8000R WG8005R WGHD5000 WM-1011 WM1203 Lg: WM-1211 Goldstar: WM-6011 WM-6021 WM8003 WM-8011 WM-1010 WMWR-1210 WR-5220 WR-6010 WR-6020 WR-8010 WR-8020 Kenmore: 580.72087 200 580.73083 300 580.73093 300 580.73104 300 580.74103 300 580.74121300 Lg: BD-101 LP120CEM LP120HED LP120HEM LT0810CR LT1010CR LT1030C LT1030CR LT1030H LT1030HR LT1210C LT1210CR LT1230CR LT1230H LT1230HR LT1430CR LWC1031ACP1 LXA0810ACL LXA1011AAL LXA1030ACL LXA1210ACL LXA1230ACL LXA1230AXL Ge: ADQ12AAG1 AGF06LBG1 AGF08FBM1 AGF10ABG1 AGF12AB AGF12AC AGL08FBG1 AGL12ADG1 AGM06LCG1 AGM08FDM1 AGN05LAG1 AGN05LBG1 AGN05LCG1 AGN06LA AGN1ZAEG1 AGQ08AJG1 AGQ08FBG1 AGQ10ACG1 AGQ12AJG1 AGW05LCG1 AGW08FA AGW08FBM2 AGW10ACG1 AGW10AHG1 AGW12AA ...
The office of the Attorney General of the Federation (AGF) and Minister for Justice, Abubakar Malami (SAN) said it expects the leader of the Indigenous People of Biafra (IPOB), Nnamdi Kanu to appear in court for his ongoing trial over alleged treason.
The association of obesity with critical chronic diseases including CVD is well-confirmed. PTX3 may act as a cardioprotective biomarker by decreasing inflammation in cardiovascular bed[2, 28]. However, it may also contribute to atherogenic process. These contradictory findings make PTX3 an important parameter to be investigated. Negative correlations between PTX3 and IR as well as TRG were reported in some studies[3-5, 29] however, such a relation couldnt be found in the others [4, 9] including our study.. There are reports explaining that PTX3 was reduced during obesity[30-32]. Our results agree with the results obtained in these studies. Plasma PTX3 showed a nonsignificant trend towards lower levels in MO group as in one of the above studies[30].. No correlations were found between this parameter and IR, most probably because our study population is composed of prepubertal children. PTX3 can not be described as a cardiovascular biomarker in this period.. While ANGPTL4 plays antilipotoxic ...
Mazej Z , Goreshnik E. , Jaglićić Z. , Gaweł B. , Łasocha Wiesław , Grzybowska Dorota , Jaroń Tomasz , Kurzydłowski Dominik Krzysztof , Malinowski Przemysław Jan , Koźmiński Wiktor , Szydłowska Jadwiga , Leszczyński Piotr Jerzy , Grochala Wojciech , KAgF3, K2AgF4 and K3Ag2F7: Important Steps Towards a Layered Antiferromagnetic Fluoroargentate(II)., CRYSTENGCOMM, 2009, 11, s. 1702-1710 ...
Teilmann, S. C. and Christensen, S. T. (2005), Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs. Cell Biology International, 29: 340-346. doi: 10.1016/j.cellbi.2005.03.006 ...
We read with great interest the recent report by Cho et al in a July issue of Circulation Research.1 However, we were struck by a remarkable feature in a Figure 1B of their article, reproduced here in the accompanying Figure (panel I). In the upper right corner there is the unmistakable resemblance to a human face, albeit with a somewhat skeletal appearance. But what is even more surprising is that a very similar face is clearly visible in the lower right panel of their Figure 3B, reproduced here in panel II, even though this image is representative of a different animal that was studied in a separate experiment. A closer examination reveals that not only is this very same ghostly face seen in the previous image, but that the vasculature architecture in these two figures is also identical, apart from slight horizontal compression. The facial resemblance can be even better appreciated after enlargement of the region within the box (panel III). We would thus submit that there has been an ...
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Angiopoietin-1 Uncouples the VEGF Receptor from Src | Science SignalingAngiopoietin-1 Uncouples the VEGF Receptor from Src | Science Signaling

Angiopoietin-1 Uncouples the VEGF Receptor from Src Message Subject. (Your Name) has forwarded a page to you from Science ... J. S. Gutkind, Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev. Cell 14, 25 ... Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) play complementary roles in vascular development during ...
more infohttp://stke.sciencemag.org/content/1/3/ec24

Angiopoietin-related growth factor antagonizes obesity and insulin resistance.  - PubMed - NCBIAngiopoietin-related growth factor antagonizes obesity and insulin resistance. - PubMed - NCBI

Angiopoietin-related growth factor (AGF), a member of the angiopoietin-like protein (Angptl) family, is secreted predominantly ... Angiopoietin-related growth factor antagonizes obesity and insulin resistance.. Oike Y1, Akao M, Yasunaga K, Yamauchi T, ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/15778720?dopt=Abstract

Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis | CirculationAbstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis | Circulation

Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis. Eiji Horio, ... Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis ... Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis ... Abstract 11343: Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothlial Dysfunction and Atherosclerosis ...
more infohttp://circ.ahajournals.org/content/122/Suppl_21/A11343

Response of angiopoietin-like proteins 3 and 4 to hemodialysis. | Sigma-AldrichResponse of angiopoietin-like proteins 3 and 4 to hemodialysis. | Sigma-Aldrich

Response of angiopoietin-like proteins 3 and 4 to hemodialysis.. [Dana Mahmood, Elena Makoveichuk, Solveig Nilsson, Gunilla ... Patients on chronic hemodialysis (cHD) have decreased activity of lipoprotein lipase (LPL). Angiopoietin-like proteins (ANGPTL ...
more infohttps://www.sigmaaldrich.com/catalog/papers/24634330

Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.

We also tested the association of concentration of angiopoietin-2 relative to ang ... To test the hypothesis that the concentration of angiopoietin-2 relative to angiopoietin-1 may be a useful biological marker of ... Angiopoietin-1 / blood*. Angiopoietin-2 / blood*. Biological Markers / blood*. Enzyme-Linked Immunosorbent Assay. Female. ... Baseline concentration of angiopoietin-2 relative to angiopoietin-1 was significantly higher in patients who died (median, 58 [ ...
more infohttp://www.biomedsearch.com/nih/Ratio-angiopoietin-2-to-1/20581666.html

Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via...Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via...

Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell ... Corrections: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/hep.24669/abstract?globalMessage=0

Angiopoietin-like protein elisa and antibodyAngiopoietin-like protein elisa and antibody

Recombinant Protein and Angiopoietin-like protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody ... Angiopoietin-like protein 8. Angiopoietin-like protein 8 ELISA Kit. Angiopoietin-like protein 8 Recombinant. Angiopoietin-like ... Also known as Angiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein).. EG624219: Hormone ... Below are the list of possible Angiopoietin-like protein products. If you cannot find the target and/or product is not ...
more infohttps://www.mybiosource.com/protein_family.php?root=angiopoietin-like-protein

Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activityDifferential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity

... DSpace/Manakin ... Angiopoietin-like 4 (Angptl4) is a secreted protein that inhibits LPL activity and, thereby, triglyceride metabolism, but the ... "Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity." Molecular ... Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity. ...
more infohttps://dash.harvard.edu/handle/1/14065548

Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4...Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4...

Angiopoietin-like protein 4, Lipoprotein lipase, Macrophages, GW501516 National Category Biochemistry and Molecular Biology ... Angiopoietin-like protein (ANGPTL) 4 inactivates LPL and ANGPTL4 expression is controlled by peroxisome proliferator-activated ... Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 ...
more infohttp://umu.diva-portal.org/smash/record.jsf?pid=diva2:559139

The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism | Journal of...The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism | Journal of...

Stratmann, A., Risau, W. and Plate, K. H. (1998). Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a ... Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... establish a new model in angiopoietin biology, and suggest that the angiopoietins do not just act as regulators of long-term ... Angiopoietin-1 (Ang-1) has been identified as the agonistic ligand of Tie-2 (Suri et al., 1996). It regulates endothelial-cell ...
more infohttp://jcs.biologists.org/content/118/4/771

Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure | JACC: Journal of...Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure | JACC: Journal of...

Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure ... Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure ... Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure ... Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure ...
more infohttp://www.onlinejacc.org/content/43/3/423

Angiopoietin-like protein 2 (ANGPTL2) induces expressio | Open-iAngiopoietin-like protein 2 (ANGPTL2) induces expressio | Open-i

Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA expression ... fig02: Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA ... fig02: Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (a) Relative mRNA ... Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase- ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4317964_cas0105-1550-f2&req=4

tie 2 [Operative Neurosurgery]tie 2 [Operative Neurosurgery]

Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian ... Findings establish that simultaneous Tie 2 activation and Angiopoietin 2 inhibition form a powerful therapeutic strategy to ...
more infohttp://operativeneurosurgery.com/doku.php?id=tie_2

A Polyglucuronic Acid to Target the FIAF Adipokine for Slimming EffectsA Polyglucuronic Acid to Target the FIAF Adipokine for Slimming Effects

... angiopoietin-related protein 4 (ARP4), PPARγ angiopoietin related gene (PGAR), ANGPTL2, pp1158 and NL2. ... 6. S Mandard, F Zandbergen, E Va Straten, W Wahli, M Muller and S Kersten, The fasting induced adipose factor/angiopoietin-like ... It belongs to the family of fibrinogen/angiopoietinlike proteins and is also referred to as: angiopoietin-like protein 4 ( ... 5. A Xu et al, Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia ...
more infohttp://www.cosmeticsandtoiletries.com/formulating/function/active/premium-A-Polyglucuronic-Acid-to-Target-the-FIAF-Adipokine-for-Slimming-Effects-211022481.html

ActoFactor™ Recombinant Mouse soluble TIE-1/Fc Chimera | Creative BioarrayActoFactor™ Recombinant Mouse soluble TIE-1/Fc Chimera | Creative Bioarray

Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found ...
more infohttps://www.creative-bioarray.com/ActoFactor-Recombinant-Mouse-soluble-TIE-1-Fc-Chimera-CSC-CTK0790-item-4116.htm

ANGPTL4 Human Recombinant Protein - Cytokines - Recombinant Protein - Full-Length Protein - Products | ProMabANGPTL4 Human Recombinant Protein - Cytokines - Recombinant Protein - Full-Length Protein - Products | ProMab

The ANGPTL4 Flag -Tagged Fusion Protein is a 44.2kDa protein containing 392 amino acid residues of the Angiopoietin-like ... The ANGPTL4 Flag -Tagged Fusion Protein is a 44.2kDa protein containing 392 amino acid residues of the Angiopoietin-like ... ANGPTL4, NL2, ARP4, FIAF, PGAR, HFARP, pp1158, ANGPTL2, Fasting- Induced Adipose Factor, Hepatic Fibrinogen/Angiopoietin- ... Related Protein, PPARG Angiopoietin-Related Protein.. Product Order. A. Formulation. Filtered and lyophilized from 0.5mg/ml in ...
more infohttps://www.promab.com/products/full-length-proteins/recombinant-protein-full/cytokines/angptl4-human-recombinant-protein-pr20086

Angiopoietin - WikipediaAngiopoietin - Wikipedia

Angiopoietin-1 and angiopoietin-2 can form dimers, trimers, and tetramers. Angiopoietin-1 has the ability to form higher order ... is demonstrated by an increased ratio of angiopoietin-2 and angiopoietin-1 in blood serum. To be specific, angiopoietin levels ... Angiopoietin-1 encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa whereas angiopoietin-2 encodes a 496 ... Angiopoietin-2 is elevated in patients with angiosarcoma. Research has shown angiopoietin signaling to be relevant in treating ...
more infohttps://en.wikipedia.org/wiki/Angiopoietin

Angiopoietin 1 - WikipediaAngiopoietin 1 - Wikipedia

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in ... increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta. This suggests that ... Dunk C, Shams M, Nijjar S (2000). "Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration ... Cheung AH, Stewart RJ, Marsden PA (1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): ...
more infohttps://en.wikipedia.org/wiki/Angiopoietin_1

Atypical angiopoietin-like protein that regulates ANGPTL3 | PNASAtypical angiopoietin-like protein that regulates ANGPTL3 | PNAS

2009) Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in ... 2007) Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 ... Angiopoietin-like protein 8. Fabiana Quagliarini, Yan Wang, Julia Kozlitina, Nick V. Grishin, Rhonda Hyde, Eric Boerwinkle, ... Angiopoietin-like protein 8. Fabiana Quagliarini, Yan Wang, Julia Kozlitina, Nick V. Grishin, Rhonda Hyde, Eric Boerwinkle, ...
more infohttps://www.pnas.org/content/109/48/19751?ijkey=d8d54427dfe675af008df7f640b689d86ae537ac&keytype2=tf_ipsecsha

Regulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling PathwaysRegulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling Pathways

Angiopoietins are vascular factors essential for blood vessel assembly and correct organization and maturation. This study ... Regulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling Pathways. Irene Pafumi,1 Annarita Favia ... was found to modulate in vitro angiogenic responses to Angiopoietins in a specific way. 2-APB and 8Br-cADPR impaired the ... describes a novel calcium-dependent machinery activated through Angiopoietin-1/2-Tie receptor system in HUVECs monolayer. Both ...
more infohttps://www.hindawi.com/journals/bmri/2015/965271/abs/

Human Angiopoietin 2 peptide (ab172727) | AbcamHuman Angiopoietin 2 peptide (ab172727) | Abcam

Buy our Human Angiopoietin 2 peptide. Ab172727 is a blocking peptide for ab125692 and has been validated in BL. Abcam provides ... Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be ...
more infohttp://www.abcam.com/human-angiopoietin-2-peptide-ab172727.html

Angiopoietin-1 for Myocardial Angiogenesis | IntechOpenAngiopoietin-1 for Myocardial Angiogenesis | IntechOpen

Angiopoietin-1 for Myocardial Angiogenesis , IntechOpen, Published on: 2011-10-21. Authors: Vien Khach Lai, Muhammad Zeeshan ... Angiopoietin-1 for Myocardial Angiogenesis. By Vien Khach Lai, Muhammad Zeeshan Afzal, Muhammad Ashraf and Khawaja Husnain ...
more infohttps://www.intechopen.com/books/myocarditis/angiopoietin-1-for-myocardial-angiogenesis/

Recombinant human Angiopoietin 1 protein (ab69492)Recombinant human Angiopoietin 1 protein (ab69492)

Buy our Recombinant human Angiopoietin 1 protein. Ab69492 is an active full length protein produced in HeLa cells and has been ... Recombinant human Angiopoietin 1 protein. See all Angiopoietin 1 proteins and peptides. ...
more infohttp://www.abcam.com/recombinant-human-angiopoietin-1-protein-ab69492.html
  • Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. (jci.org)