Angiopoietin 2. Medical search

An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.

The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.

A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).

A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.

A TIE receptor found predominantly on ENDOTHELIAL CELLS. It is considered essential for vascular development and can form a heterodimer with the TIE-2 RECEPTOR. The TIE-1 receptor may play a role in regulating BLOOD VESSEL stability and maturation.

A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.

Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.

Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.

A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.

A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.

A species of gram-negative bacteria highly pathogenic to RATS and MICE. It is the primary cause of murine respiratory mycoplasmosis.

Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.

These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.

A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.

Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.

Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).

A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.

Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.

Glycoproteins found on the membrane or surface of cells.

The minute vessels that connect the arterioles and venules.

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.

A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.

The blood vessels which supply and drain the RETINA.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

An area approximately 1.5 millimeters in diameter within the macula lutea where the retina thins out greatly because of the oblique shifting of all layers except the pigment epithelium layer. It includes the sloping walls of the fovea (clivus) and contains a few rods in its periphery. In its center (foveola) are the cones most adapted to yield high visual acuity, each cone being connected to only one ganglion cell. (Cline et al., Dictionary of Visual Science, 4th ed)

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells.

Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.

Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Elements of limited time intervals, contributing to particular results or situations.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

The relationship between the dose of an administered drug and the response of the organism to the drug.

The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

A cell line derived from cultured tumor cells.

Established cell cultures that have the potential to propagate indefinitely.

Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (1/540)

Using homology-based PCR, we have isolated cDNA encoding a novel member (491 amino acids) of the angiopoietin (Ang) family from human adult heart cDNA and have designated it angiopoietin-3 (Ang3). The NH2-terminal and COOH-terminal portions of Ang-3 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in other known Angs. Ang3 has a highly hydrophobic region at the N-terminus (approximately 21 amino acids) that is typical of a signal sequence for protein secretion. Ang3 mRNA is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine in human adult tissues. Additionally, Ang3 is a secretory protein, but is not a mitogen in endothelial cells. (+info)

Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. (2/540)

Recent studies have shown that the angiopoietin-Tie2 system is a predominant regulator of vascular integrity. In this study, we investigated the effect of two known angiogenic stimuli, hypoxia and vascular endothelial growth factor (VEGF), on these molecules. VEGF induced both a time- and concentration-dependent increase in angiopoietin-2 (Ang2) mRNA expression in bovine microvascular endothelial cells. This up-regulation was derived primarily from an increased transcription rate as evidenced by nuclear run-on assay and mRNA decay study. The increased Ang2 expression upon VEGF treatment was almost totally abolished by inhibition of tyrosine kinase or mitogen-activated protein kinase and partially by suppression of protein kinase C. Hypoxia also directly increased Ang2 mRNA expression. In contrast, Ang1 and Tie2 responded to neither of these stimuli. The enhanced Ang2 expression following VEGF stimulation and hypoxia was accompanied by de novo protein synthesis as detected by immunoprecipitation. In a mouse model of ischemia-induced retinal neovascularization, Ang2 mRNA was up-regulated in the ischemic inner retinal layer, and remarkable expression was observed in neovascular vessels. These data suggest that both hypoxia- and VEGF-induced neovascularization might be facilitated by selective induction of Ang2, which deteriorates the integrity of preexisting vasculature. (+info)

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. (3/540)

In contrast with the prevailing view that most tumors and metastases begin as avascular masses, evidence is presented here that a subset of tumors instead initially grows by coopting existing host vessels. This coopted host vasculature does not immediately undergo angiogenesis to support the tumor but instead regresses, leading to a secondarily avascular tumor and massive tumor cell loss. Ultimately, however, the remaining tumor is rescued by robust angiogenesis at the tumor margin. The expression patterns of the angiogenic antagonist angiopoietin-2 and of pro-angiogenic vascular endothelial growth factor (VEGF) suggest that these proteins may be critical regulators of this balance between vascular regression and growth. (+info)

Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes. (4/540)

PURPOSE: To elucidate the potential role of angiopoietins and the Tie2 system in choroidal neovascularization. METHODS: Surgically excised choroidal neovascular membranes (CNVMs) were obtained at vitrectomy from five eyes with age-related macular degeneration, three eyes with idiopathic neovascular maculopathy, and two eyes had degenerative myopia and two eyes had angioid streaks. Light microscopic immunohistochemistry was performed to detect cytokines such as vascular endothelial growth factor (VEGF), Ang1, and Ang2 and cellular components such as retinal pigment epithelial (RPE) cells, macrophages, and endothelial cells. Immunofluorescent double staining using confocal microscopy was performed to identify the cell types that secrete specific cytokines. RESULTS: Ang1 and Ang2 were positive in all surgically excised CNVMs, regardless of the primary disease. Double staining revealed that many of the cytokeratin, CD68 and factor VIII positive cells also had Ang1 and Ang2 immunoreactivities. In contrast to Ang1, Ang2 immunoreactivity tends to be higher in the highly vascularized regions of many CNVMs, and the localization was very similar to that of VEGF staining. Almost all vascular structures had prominent immunoreactivity for Tie2, which was confirmed by double staining for Tie2 and factor VIII. Tie2 immunoreactivity was also observed in the RPE monolayer and in pigmented, polygonal, and fibroblast-like cells in the stroma. CONCLUSIONS: Present findings that Ang2 and VEGF are co-upregulated and that Tie2 is expressed in a variety of cell types in CNVMs further support a crucial role of the interaction between VEGF and Ang2 in pathologic angiogenesis of CNVM formation. (+info)

Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. (5/540)

The Tie-2 receptor tyrosine kinase transduces embryonic endothelial differentiation, with Angiopoietin-1 (Ang-1) acting as a stimulatory ligand and Ang-2 postulated to be a naturally occurring inhibitor. Expression of these genes was sought during mouse kidney maturation from the onset of glomerulogenesis (embryonic day 14 [E14]) to the end of nephron formation (2 wk postnatal [P2]), and during medullary maturation into adulthood (P8). Using Northern and slot blotting of RNA extracted from whole organs, these three genes were expressed throughout the experimental period with peak levels at P2 to P3. By in situ hybridization analysis at E18, P1, and P3, Ang-1 mRNA was found to localize to condensing renal mesenchymal cells, proximal tubules, and glomeruli in addition to maturing tubules of the outer medulla. In contrast, Ang-2 transcripts were more spatially restricted, being detected only in differentiating outer medullary tubules and the vasa recta bundle area. Using in situ hybridization and immunohistochemistry, Tie-2 was detected in capillaries of the nephrogenic cortex, glomerular tufts, cortical interstitium, and medulla including vessels in the vasa recta. Using Western blotting of protein extracted from whole organs, Tie-2 protein was detected between E14 and P8 with tyrosine phosphorylated Tie-2 evident from E18. These data are consistent with the hypothesis that Tie-2 has roles in maturation of both glomeruli and vasa rectae. (+info)

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. (6/540)

Our analyses in several different tumor settings challenge the prevailing view that malignancies and metastases generally initiate as avascular masses that only belatedly induce vascular support. Instead, we find that malignant cells rapidly co-opt existing host vessels to form an initially well-vascularized tumor mass. Paradoxically, the co-opted vasculature does not undergo angiogenesis to support the growing tumor, but instead regresses (perhaps as part of a normal host defense mechanism) via a process that involves disruption of endothelial cell/smooth muscle cell interactions and endothelial cell apoptosis. This vessel regression in turn results in necrosis within the central part of the tumor. However, robust angiogenesis is initiated at the tumor margin, rescuing the surviving tumor and supporting further growth. The expression patterns of Angiopoietin-2 (the natural antagonist for the angiogenic Tie2 receptor) and vascular endothelial growth factor (VEGF) strongly implicate these factors in the above processes. Angiopoietin-2 is highly induced in co-opted vessels, prior to VEGF induction in the adjacent tumor cells, providing perhaps the earliest marker of tumor vasculature and apparently marking the co-opted vessels for regression. Subsequently, VEGF upregulation coincident with Angiopoietin-2 expression at the tumor periphery is associated with robust angiogenesis. Thus, in tumors, Angiopoietin-2 and VEGF seem to reprise the roles they play during vascular remodeling in normal tissues, acting to regulate the previously underappreciated balance between vascular regression and growth. (+info)

Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity. (7/540)

Activity of endothelial Tie2 receptor tyrosine kinase is modulated by two naturally occurring, secreted ligands, angiopoietin-1 and -2, which have opposing effects on its phosphorylation. Receptor tyrosine kinase activation requires receptor dimerization/multimerization, which, for many receptors, is mediated by homo-oligomeric ligands binding to and bridging receptor molecules. We show here that angiopoietin-1 and -2 form distinct arrays of disulfide-linked homo-oligomeric complexes. Their mobilities on nonreducing gels suggest that angiopoietin-2 exists predominantly as a homodimer but also forms higher order multimers. In contrast, angiopoietin-1 forms some homotrimers, but predominantly exists in higher order multimers. These two structurally related, 60% homologous ligands are predominantly composed of an amino-terminal coiled coil domain and a carboxyl-terminal fibrinogen-like domain. We show that their distinct oligomerization patterns are determined by their coiled coil domains and, furthermore, that their coiled coil domains, but not their fibrinogen-like domains, are sufficient to mediate formation of disulfide-linked homo-oligomers. In contrast, the differential effects of these ligands on endothelial Tie2 phosphorylation is mediated by their fibrinogen-like domains. We conclude from these studies that the coiled coil and fibrinogen-like domains of the angiopoietins have distinct functions with the coiled coil domain mediating ligand homo-oligomerization and the fibrinogen-like domain mediating ligand activity. (+info)

Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval. (8/540)

The role of endothelial cell-specific growth factors in the vascularization of the primate peri-ovulatory follicle was examined. Experiments were designed firstly to detect expression of vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) in granulosa cells and secondly, to determine whether gonadotrophins and/or steroids regulate their expression during the peri-ovulatory interval. Granulosa cells and follicular fluid were collected from rhesus macaques undergoing ovarian stimulation before (0 h), 12, or 36 h after a bolus of ovulatory human chorionic gonadotrophin (HCG), with or without steroid ablation and progestin replacement. VEGF, Ang-1 and Ang-2 mRNA were all detected prior to the ovulatory stimulus. Whereas follicular fluid VEGF concentrations increased 6-fold (P < 0.05) between 0 and 12 h, VEGF mRNA values were unchanged and were unaffected by steroid ablation. Ang-1 mRNA decreased from 0 to 12 h (P < 0.05), followed by a 30-fold increase (P < 0.05) at 36 h, while Ang-2 mRNA values were unchanged between 0, 12 and 36 h. Steroid ablation decreased (P < 0.05) Ang-1 mRNA at 36 h, and Ang-2 mRNA at 12 h, while only Ang-1 was restored by progestin replacement. These data suggest a dynamic expression of vascular-specific growth factors in a gonadotrophin-dependent, steroid-independent (VEGF) or steroid-dependent (Ang-1) manner in granulosa cells of peri-ovulatory follicles of primates. (+info)

Angiopoietin 2. antagonist of angiopoietin 1. TSP-1 and TSP-2. inhibit cell migration, cell proliferation, cell adhesion and ... 2 (4): 263-70. doi:10.1021/cb600362d. PMID 17432820.. *^ Aftab, B. T.; Dobromilskaya, I.; Liu, J. O.; Rudin, C. M. (2011). " ... Meth-1 and Meth-2. IFN-α, -β and -γ, CXCL10, IL-4, -12 and -18. inhibit cell migration of endothelial cells, downregulate bFGF ... 275 (2): 1209-15. doi:10.1074/jbc.275.2.1209. PMID 10625665.. *^ Lee, SJ.; Nathans, D. (Mar 1988). "Proliferin secreted by ...

https://en.wikipedia.org/wiki/Angiogenesis_inhibitor

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... 274 (2): 337-43. doi:10.1006/bbrc.2000.3142. PMID 10913340.. *^ Koga C, Adati N, Nakata K, Mikoshiba K, Furuhata Y, Sato S, Tei ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 2] cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be expressed in normal brain, ...

https://en.wikipedia.org/wiki/FGF20

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 2 (3): 157-77. doi:10.1002/aur.80. PMID 19598235.. *. Mizuno N, Shiba H, Inui T, et al. (2008). "Effect of neurotrophin-4/5 on ...

https://en.wikipedia.org/wiki/NT-4

https://en.wikipedia.org/wiki/GFRα

Activation of the Tie2 receptor by the ligand Angiopoietin 2. This has been shown in vitro and in vivo. Activation of the ... Activation of the signaling pathway by Delta4, Angiopoietin 2, insulin, or a combination of the three and a JAK inhibitor ... Angiopoietin 2). Hes3, in turn, by regulating the expression of Shh and potentially other factors, can also exert an effect on ... Angiopoietin 2, insulin, or a combined treatment consisting of all three factors and an inhibitor of JAK) induce the increase ...

https://en.wikipedia.org/wiki/Hes3_signaling_axis

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive ... N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide ...

https://en.wikipedia.org/wiki/Afatinib

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... 88 (2): 595-603. doi:10.1152/jn.2002.88.2.595. PMID 12163512.. *^ Chou WH, Wang D, McMahon T, Qi ZH, Song M, Zhang C, Shokat KM ... 16 (2): 477-83. doi:10.1017/S1461145712000685. PMC 3802523. PMID 22827965.. *^ Egan MF, Kojima M, Callicott JH, Goldberg TE, ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ...

https://en.wikipedia.org/wiki/BDNF

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... 28A (2): 102-8. doi:10.1007/BF02631013. PMID 1537750.. *^ "Researchers make older beta cells act young again". Eurekalert.org. ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... doi:10.1016/0896-6273(90)90215-2. PMID 2171589.. *^ Paul D, Lipton A, Klinger I (1971). "Serum factor requirements of normal ...

https://en.wikipedia.org/wiki/Platelet-derived_growth_factor

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 46 (2): 101-110. doi:10.1046/j.1365-2125.1998.00764.x. ISSN 0306-5251. PMC 1873672. PMID 9723817.. ... 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)- 5-(trifluoromethyl)phenyl]-3- [(4-pyridin-3-ylpyrimidin-2-yl) amino]benzamide ...

https://en.wikipedia.org/wiki/Nilotinib

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 2 (3): 155-64. doi:10.1038/35058515. PMID 11256076.. *. Kozlosky CJ, Maraskovsky E, McGrew JT, et al. (1995). "Ligands for the ... 10 (2): 299-306. PMID 7838529.. *. Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two ...

https://en.wikipedia.org/wiki/EFNA4

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... 15 (2): 120-5. doi:10.1177/1534734616645444. PMID 27151755. S2CID 43897291.. *^ a b Martí-Carvajal AJ, Gluud C, Nicola S, ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... doi:10.1016/S0014-4827(02)00105-2. PMID 12648462.. *^ Carpenter G, Cohen S (May 1990). "Epidermal growth factor". The Journal ...

https://en.wikipedia.org/wiki/Epidermal_growth_factor

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 110 (2): 175-91. doi:10.1042/CS20050161. PMID 16411894.. *^ Eriksson; et al. (November 1998). "Neurogenesis in the adult human ... ISBN 978-0-12-385870-2.. *^ Bamji, SX (1998). "The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for ...

https://en.wikipedia.org/wiki/Neurotrophy

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 2,3-d]-pyrimidine derivatives such as NVP-AEW541[23]). The monoclonal antibody figitumumab which targets the IGF-1R is ...

https://en.wikipedia.org/wiki/Erlotinib

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 9 (2): 97-109. doi:10.1002/(SICI)1098-1004(1997)9:2,97::AID-HUMU1,3.0.CO;2-M. PMID 9067749.. ... doi:10.1016/s0003-4266(05)81748-2. PMID 15988377.. *. Lantieri F, Griseri P, Ceccherini I (2006). "Molecular mechanisms of RET- ...

https://en.wikipedia.org/wiki/RET_proto-oncogene

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... 7 (2): 228-34. doi:10.1038/84683. PMID 11175855. S2CID 40934433.. *^ a b Weisberg E, Manley PW, Cowan-Jacob SW, Hochhaus A, ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 5 (2): 117-22. PMID 16485879.. *^ Klopp, T, ed. (2010). Arzneimittel-Interaktionen (in German) (2010/2011 ed.). ...

https://en.wikipedia.org/wiki/Imatinib

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 110 (2): 175-91. doi:10.1042/CS20050161. PMID 16411894.. *^ Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C ... 978-0-12-385870-2. .. *^ Bamji SX, Majdan M, Pozniak CD, Belliveau DJ, Aloyz R, Kohn J, Causing CG, Miller FD (February 1998). ...

https://en.wikipedia.org/wiki/Neurotrophins

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 44 (2): 79-87. PMID 20066808.. *^ Counts SE, Mufson EJ (Apr 2005). "The role of nerve growth factor receptors in cholinergic ... 110 (2): 175-91. doi:10.1042/CS20050161. PMID 16411894.. *^ Barry SR (Dec 1991). "Clinical implications of basic neuroscience ...

https://en.wikipedia.org/wiki/Nerve_growth_factor

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... 356 (2): 125-34. doi:10.1056/NEJMoa060655. PMID 17215530.. *^ a b "Pharmaceutical Benefits Scheme (PBS) -SORAFENIB". ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 69 (2): 223-40. doi:10.2165/00003495-200969020-00006. PMID 19228077.. *^ Zhang Y (Jan 2014). "Screening of kinase inhibitors ...

https://en.wikipedia.org/wiki/Sorafenib

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... Vandetanib (INN, trade name Caprelsa)[2] is an anti-cancer drug that is used for the treatment of certain tumours of the ... Starkey, Jonathan (August 2, 2011). "AstraZeneca (finally) lands name for cancer drug". Delaware Inc.. ...

https://en.wikipedia.org/wiki/Vandetanib

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... 35 (2): 376-9. doi:10.1006/geno.1996.0371. PMID 8661153.. *^ Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (Oct ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 2 (3): 155-64. doi:10.1038/35058515. PMID 11256076.. *. Winslow JW, Moran P, Valverde J, et al. (1995). "Cloning of AL-1, a ...

https://en.wikipedia.org/wiki/EFNA5

It targets the protein angiopoietin 2. As of May 2017[update], it is in Phase II clinical trials for the treatment of diabetic ... "Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of ... Clinical trial number NCT02713204 for "Anti-angiOpoeitin 2 Plus Anti-vascular eNdothelial Growth Factor as a therapY for ...

https://en.wikipedia.org/wiki/Nesvacumab

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... doi:10.1088/1741-2560/3/2/011. PMID 16705273.. *^ a b c d Henderson, Christopher E (1996-02-01). "Role of neurotrophic factors ... doi:10.1016/s0896-6273(00)80039-2. PMID 8789936.. *^ a b Lambert, P. D.; Anderson, K. D.; Sleeman, M. W.; Wong, V.; Tan, J.; ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ...

https://en.wikipedia.org/wiki/Neurotrophic_factors

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... 2 (5): 561-6. doi:10.1038/nm0596-561. PMID 8616716.. *^ Strawn LM, McMahon G, App H, Schreck R, Kuchler WR, Longhi MP, Hui TH, ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu ...

https://en.wikipedia.org/wiki/Tyrosine-kinase_inhibitor

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... 2 Preclinical and Clinical testing *2.1 Advanced non-smallcellular lung carcinoma. *2.2 Advanced adenocarcinomas of stomach and ... Mutations in the kinase domain of the EGFR are observed with approximately 2 to 25% of non-small cell lung carcinoma (NSCLC) ...

https://en.wikipedia.org/wiki/Matuzumab

... and angiopoietins, that play the key roles in the blood vessel formation. National Science Contest for Elementary School ... "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis". Cell. 87 (7): 1171-1180. doi: ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ... October 1993). "Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic ...

https://en.wikipedia.org/wiki/Thomas_N._Sato

"Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization". Circulation Research. 83 (3): 233-40. ... Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the ... Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (November 2001). "Dok-R plays a pivotal role in angiopoietin-1- ...

https://en.wikipedia.org/wiki/TEK_tyrosine_kinase

Angiopoietin 2 can act as an antagonist to Tie-2, destabilizing the endothelial cells, which results in less endothelial cell ... Angiopoietin 1 and Tie-2 signaling is essential for maturation and stabilization of endothelial cells. Platelet-derived growth ... Similar to the inhibition of the PDGF pathway, angiopoietin 2 reduces levels of pericytes, leading to diabetic retinopathy. ... "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...

https://en.wikipedia.org/wiki/Pericyte

He later showed that inhibition of the Tie2-ligand Angiopoietin 2 induces tumor regression and inhibits metastasis by ... He also identified expression of Angiopoietin 2 as an adaptive resistance mechanism upon anti-angiogenic treatment by VEGF ... "Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade". Cell Reports. 8 (3): 696-706. doi:10.1016/j. ... "Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade". Science ...

https://en.wikipedia.org/wiki/Michele_De_Palma

Regulation by Hypoxia and Angiopoietin-2". Cancer Research. 67 (18): 8429-8432. doi:10.1158/0008-5472.CAN-07-1684. ISSN 0008- ... 2: 89. doi:10.3389/fonc.2012.00089. ISSN 2234-943X. PMC 3412458. PMID 22888475. Okubo, Makiko; Kioi, Mitomu; Nakashima, ...

https://en.wikipedia.org/wiki/Host_response_to_cancer_therapy

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene. Angiopoietins are proteins with important roles in ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3-4): 147-54. ... "Entrez Gene: ANGPT4 angiopoietin 4". Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser. ...

https://en.wikipedia.org/wiki/ANGPT4

In the combined absence of angiopoietin 1 and angiopoietin 2, Schlemm's canal and episcleral lymphatic vasculature completely ... 2][3][4] Developmental studies revealed that Schlemm's canal develops via a unique mechanism involving the transdifferentiation ... 2][3][4] It is named after Friedrich Schlemm (1795-1858), a German anatomist. ... of venous endothelial cells in the eye into lymphatic-like endothelial cells.[2][3][4] ...

https://en.wikipedia.org/wiki/Canal_of_Schlemm

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'- ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... Study 2: 61% pegaptanib vs. 34% placebo. Regulatory information[edit]. Pegaptanib (pegaptanib sodium injection) has been ...

https://en.wikipedia.org/wiki/Pegaptanib

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... IGF-2 exerts its effects by binding to the IGF-1 receptor and to the short isoform of the insulin receptor (IR-A or exon 11-).[ ... Insulin-like growth factor 2 has been shown to interact with IGFBP3[15][16][17][18] and transferrin.[15] ...

https://en.wikipedia.org/wiki/Insulin-like_growth_factor_2

Migrasi ini dimediasi oleh beberapa senyawa antara lain eritropoietin,[70] stromal-derived factor 1 (SDF-1) dan angiopoietin-1 ... Sel TH1 CD4+ dengan sekresi sitokina pro-radang termasuk IL-2, IL-12, IFN-γ dan TNF-α dapat memperburuk efek yang ditimbulkan ... "Københavns praktiserende laegers laboratorium, AFASAK 2 Center; Koefoed BG, Gulløv AL, Petersen P. Diakses tanggal 2011-08-21. ... Selain itu, akan tampak ekspresi gen iNOS di sel vaskular maupun sel yang mengalami peradangan dan ekspresi gen COX-2 di sel ...

https://id.wikipedia.org/wiki/Stroke

Angiopoietin-2 works with VEGF to facilitate cell proliferation and migration of endothelial cells ...

https://en.wikipedia.org/wiki/Endothelium

Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription. Cell 2006; 124, 275-286 Abstract ... 2006;3(2):120-1 Free Full Text *↑ Karachalias N, Babaei-Jadidi R, Kupich C, Ahmed N, Thornalley PJ. High-dose thiamine therapy ... 2006;530(1-2):48-53. Abstract *↑ Cameron NE, Gibson TM, Nahgle MR, Cotter MA. Inhibitors of advanced glycation end product ... 2006;394(2):158-62. Abstract *↑ Lüttke A. Benfotiamin schützt vor schädlichen AGEs. Deutsches Diabetes-Zentrum DDZ Düsseldorf ...

https://fi.wikipedia.org/wiki/Benfotiamiini

December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 ( ... Yancopoulos has cloned novel families of growth factors, including ephrins/Ephs and angiopoietins, and elucidated the basis of ... Yancopoulos is the holder of more than 100 patents.[2] He is a principal inventor and developer of Regeneron's six FDA-approved ...

https://en.wikipedia.org/wiki/George_Yancopoulos

Angiopoietin. *Agonists: Angiopoietin 1. *Angiopoietin 4. *Antagonists: Angiopoietin 2. *Angiopoietin 3. *Kinase inhibitors: ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... IL-2 - T-cell growth factor. Stimulates IL-1 synthesis. Activates B-cells and NK cells. ... For example, epidermal growth factor (EGF) enhances osteogenic differentiation, [2] while fibroblast growth factors and ...

https://en.wikipedia.org/wiki/Growth_factor

Dodatne komponente Weibel-Paladeovog tijela su hemokini interleukin-8 i eotaksin-3, endotelin-1, angiopoietin-2, ...

https://bs.wikipedia.org/wiki/Weibel–Paladeovo_tijelo

"GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4". The Journal ... angiopoietin-like protein 4, and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 in subjects ... with and without type 2 diabetes mellitus". Metabolism. 61 (5): 652-660. doi:10.1016/j.metabol.2011.09.014. PMID 22078753.. ...

https://ar.wikipedia.org/wiki/GPIHBP1

Mediators that promote angiogenesis are angiopoietin and vascular endothelial growth factor (VEGF). Prostaglandin E2 promotes ... 60 (2): 55-61. PMID 23918031. Retrieved 26 November 2017.. *^ a b Fig 3 in: Rao, Murali Gundu (2016). "Dating of Early Subdural ... doi:10.1016/S0140-6736(09)61682-2. PMID 19782854. S2CID 29932520.. *^ Santarius T, Kirkpatrick PJ, Dharmendra G, et al. (2009 ... 2] Symptoms of chronic subdural hematomas are usually delayed four to seven weeks.[citation needed] ...

https://en.wikipedia.org/wiki/Subdural_haematoma

Li, J. J.; Huang, Y. Q.; Basch, R.; Karpatkin, S. (February 2001). "Thrombin induces the release of angiopoietin-1 from ... Angiopoietin-1[53]) and cytokines including the EMT inducer TGF-β.[54] The release of TGF-β by platelets in blood vessels near ... 85 (2): 204-206. ISSN 0340-6245. PMID 11246533.. *^ Assoian, R. K.; Komoriya, A.; Meyers, C. A.; Miller, D. M.; Sporn, M. B. ( ... 13 (2): 97-110. doi:10.1038/nrc3447. PMID 23344542.. *^ Chakrabarti R, Hwang J, Andres Blanco M, Wei Y, Lukačišin M, Romano RA ...

https://en.wikipedia.org/wiki/Epithelial–mesenchymal_transition

ANGPTL1: Angiopoietin-related protein 1. *ARHGEF2 (1q22). *ARID4B: encoding protein AT-rich interactive domain-containing ... 978-1-136-84407-2. .. *^ a b Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last ... Tom Strachan; Andrew Read (2 April 2010). Human Molecular Genetics. Garland Science. p. 45. ISBN ... AZIN2: encoding enzyme Antizyme inhibitor 2 (AzI2) also known as arginine decarboxylase (ADC) ...

https://en.m.wikipedia.org/wiki/Chromosome_1

Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted ... and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J Biol ... Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 ... Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific ...

https://en.wikipedia.org/wiki/Angiopoietin-related_protein_2

Buy our Human Angiopoietin 2 peptide. Ab172727 is a blocking peptide for ab125692 and has been validated in BL. Abcam provides ... Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be ... Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw ...

http://www.abcam.com/human-angiopoietin-2-peptide-ab172727.html

Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of ...

https://www.jci.org/articles/view/99659/ga

Plasma angiopoietin-1, angiopoietin-2, angiopoietin receptor tie-2, and vascular endothelial growth factor levels in acute ... Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction. Seung-Jun Lee,1 Choong-kun Lee,1,2 ... Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population. Eur J Heart Fail. 2013;15(12): ... Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med. 2006 ...

https://www.jci.org/articles/view/99659

Abcams Angiopoietin 2 ELISA Kit suitable for Cell culture supernatant, Urine, Serum, Heparin Plasma, EDTA Plasma in mouse. ... Abcams mouse Angiopoietin-2 in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate quantitative ... An Angiopoietin-2 specific rat monoclonal antibody has been precoated onto 96-well plates. Standards and test samples are added ... Get better reproducibility in only 90 minutes with Mouse Angiopoietin 2 ELISA Kit (ab209883) from our SimpleStep ELISA® range. ...

http://www.abcam.com/mouse-angiopoietin-2-elisa-kit-ab171335.html

2007) Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2. BMC Cell ... 2011) Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest 121:2278- ... 2006) Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med ... 2016) Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII. eLife 5:e21032. ...

https://www.pnas.org/content/115/6/1298

Tag: Plasma angiopoietin-2. (icTV) CLINICAL TRIALS RESULTS ~ Plasma angiopoietin-2 & ARDS risk in sepsis. Posted on 22 October ... Posted in ARF, Article links, ICM News, icTV Footage, SISTagged ards, congress, esicm, LIVES, Plasma angiopoietin-2, RCT, ... Resources , News , (icTV) CLINICAL TRIALS RESULTS ~ Plasma angiopoietin-2 & ARDS risk in sepsis. (icTV) CLINICAL TRIALS RESULTS ... icTV) CLINICAL TRIALS RESULTS Plasma angiopoietin-2 & ARDS risk in sepsis In this icTV interview, presenter John Reilly ...

https://www.esicm.org/tag/plasma-angiopoietin-2/

Browse our Angiopoietin-2 Antibodies all backed by our Guarantee+. ... anti-angiopoietin-2a antibody, anti-angiopoietin-2B antibody, anti-angiopoitin 2 antibody, anti-Tie2-ligand antibody ... Each Angiopoietin-2 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you ... Our Angiopoietin-2 Antibodies can be used in a variety of model species: Chicken, Human, Mouse. Use the list below to choose ...

https://www.novusbio.com/primary-antibodies/angiopoietin-2

Compare Angiopoietin 2 ELISA Kits from Biorbyt from leading suppliers on Biocompare. View specifications, prices, citations, ... Angiopoietin 2 ELISA Kits from Biorbyt. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool ... Your search returned 7 Angiopoietin 2 ELISA ELISA Kit across 1 supplier. ... 1 x 48 Discovery (pre-coated), 1 x 96 (pre-coated), 2 x 96 (pre-coated) ...

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Compare Angiopoietin 2 ELISA Kits from RayBiotech from leading suppliers on Biocompare. View specifications, prices, citations ... Angiopoietin 2 ELISA Kits from RayBiotech. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based ... Your search returned 5 Angiopoietin 2 ELISA ELISA Kit across 1 supplier. ...

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View our 7 Angiopoietin-2 products for your research including Angiopoietin-2 Proteins and Enzymes and Angiopoietin-2 Primary ... Angiopoietin-2: Products. Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that regulates vascular remodeling by ... Ang-2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the ... It associates into dimers, trimers, and larger multimers and binds the receptor Tie-2, with its function as an agonist or ...

https://www.rndsystems.com/target/angiopoietin-2?low_endotoxin=true

Angiopoietin-2 (Ang-2) modulates Tie-2 receptor activation. In mouse kidney maturation, Ang-2 is expressed in arteries, with ... We hypothesized that Ang-2 deficiency disrupts kidney vessel patterning. The normal renal cortical peritubul … ... lower levels in tubules, whereas Tie-2 is expressed by endothelia. ... Angiopoietin-2 (Ang-2) modulates Tie-2 receptor activation. In mouse kidney maturation, Ang-2 is expressed in arteries, with ...

https://pubmed.ncbi.nlm.nih.gov/15579434/

Ausgesuchte Qualitäts-Hersteller für Angiopoietin 2 Antikörper. Hier bestellen. ... Monoklonale und polyklonale Angiopoietin 2 Antikörper für viele Methoden. ... angiopoietin-2B , angiopoietin-2a , angiopoietin 2 , Angiopoietin-2B (Ang-2B) , angiopoietin-2A , angiopoietin-2-like , ... Angiopoietin 2 (ANGPT2) Antigen-Profil Protein Überblick The protein encoded by this gene is an antagonist of angiopoietin 1 ( ...

https://www.antikoerper-online.de/rtk-signalweg-pathway-8/angiopoietin-2-antibody-566/

Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat ... Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat ... Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat ... Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat ...

https://science.sciencemag.org/content/343/6169/416/tab-e-letters

Hu et al. (p. 416) found that rapid down-regulation of endothelial-derived Angiopoietin-2 following partial hepatectomy ... Here, we show that the expression of Angiopoietin-2 (Ang2) in LSECs is dynamically regulated after partial hepatectomy. During ... Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat ... Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat ...

https://science.sciencemag.org/content/343/6169/416.abstract?ijkey=QFigd%3EgL/%3E.XRow&keytype=ref&siteid=sci

Order monoclonal and polyclonal Angiopoietin 2 antibodies for many applications. Selected quality suppliers for anti- ... angiopoietin-2B , angiopoietin-2a , angiopoietin 2 , Angiopoietin-2B (Ang-2B) , angiopoietin-2A , angiopoietin-2-like ... Angiopoietin 2 (ANGPT2) Antigen Profile Protein Summary The protein encoded by this gene is an antagonist of angiopoietin 1 ( ... anti-Angiopoietin 2 Antibodies 171 Angiopoietin 2 (ANGPT2) Antibodies from 26 manufacturers are available on www.antibodies- ...

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Compare and order Angiopoietin 2 ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. ... angiopoietin-2B , angiopoietin-2a , Angiopoietin-2B (Ang-2B) , angiopoietin-2A ... Angiopoietin 2 Antigen Profile Antigen Summary The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and ... Search Angiopoietin 2 ELISA Kits for other reactivities: Rabbit,. Chicken,. Guinea Pig,. Wild boar (Sus scrofa),. Cow (Bovine), ...

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Anti-Angiopoietin 2 pAb (GTX10601) is tested in Human samples. 100% Ab-Assurance. ... Angiopoietin 2 antibody (angiopoietin 2) for ELISA, IHC-P, WB. ... Angiopoietin 2 probably acts as a natural antagonist for Ang1 ... angiopoietin 2. Background. Angiopoietin 2 and angiopoietin 1 have an N-terminal coiled-coil domain and a C-terminal fibrinogen ... Recombinant human angiopoietin 2 has a molecular mass of approximately 66 kDa in SDS-PAGE under reducing and non-reducing ...

http://www.genetex.com/Angiopoietin-2-antibody-GTX10601.html

Human Angiopoietin-2 protein (623-AN) is manufactured by R&D Systems, over 97% purity. Reproducible results in bioactivity ... Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint Therapy. Authors: Wu X, Giobbie-Hurder A, Liao X, Connelly C, ... The role of angiopoietin-2 in nucleus pulposus cells during human intervertebral disc degeneration Authors: K Wang, W Liu, Y ... Recombinant Human Angiopoietin-2 Protein Summary. Purity. >97%, by SDS-PAGE visualized with Silver Staining and quantitative ...

https://www.rndsystems.com/products/recombinant-human-angiopoietin-2-protein_623-an

Differential expression of angiopoietin-1 and angiopoietin-2 in colon carcinoma. A possible mechanism for the initiation of ... Angiopoietin-2 Stimulates Breast Cancer Metastasis through the α5β1 Integrin-Mediated Pathway. Yorihisha Imanishi, Bo Hu, ... Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival. Int J Cancer 2003; 103: 466- ... Expression of angiopoietins and its clinical significance in non-small cell lung cancer. Cancer Res 2002; 62: 7124-9. ...

https://cancerres.aacrjournals.org/content/67/9/4254?ijkey=4b3f929989f0c90f9e8ccc5a3f2f211971a864f7&keytype2=tf_ipsecsha

In our study, the expression of Angiopoietin-1 (ANG1) and Angiopoietin-2 (ANG2) mRNA in archival human breast cancer tumor ... In our study, the expression of Angiopoietin-1 (ANG1) and Angiopoietin-2 (ANG2) mRNA in archival human breast cancer tumor ... Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival Int J Cancer. 2003 Feb 10;103 ...

https://pubmed.ncbi.nlm.nih.gov/12478661/?dopt=Abstract

Order this anti-Angiopoietin 2 antibody. , Product number ABIN95113 ... Rabbit Polyclonal Angiopoietin 2 antibody N-Term for WB. Published in 1 Pubmed Reference. ... Product Details anti-Angiopoietin 2 Antibody References Images Handling Application Details Target Details back to top ... anti-Mouse (Murine) Angiopoietin 2 antibody for Western Blotting Show more 45 anti-Mouse (Murine) Angiopoietin 2 antibody for ...

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What is angiopoietin 2? Meaning of angiopoietin 2 medical term. What does angiopoietin 2 mean? ... Looking for online definition of angiopoietin 2 in the Medical Dictionary? angiopoietin 2 explanation free. ... Most studies have reported vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), and angiopoietin 2 (Ang-2) to be ... angiopoietin 1 and angiopoietin 2, placental growth factor, and platelet-derived growth factor-B [29].. Comparative analysis of ...

https://medical-dictionary.thefreedictionary.com/angiopoietin+2

Roles of Angiopoietin Like Protein-2 in Corneal Neovascularization You will receive an email whenever this article is corrected ... Purpose: : To examine the roles of angiopoietin like protein 2 (Angptl2) in corneal neovascularization using transgenic mice ... T. Usui, S. Yokoo, S. Amano, Y. Oike; Roles of Angiopoietin Like Protein-2 in Corneal Neovascularization. Invest. Ophthalmol. ...

https://iovs.arvojournals.org/article.aspx?articleid=2374306

Role of angiopoietin-2 in venous thrombus resolution and chronic thromboembolic disease. Lukas Hobohm, Sebastian Kölmel, ... Role of angiopoietin-2 in venous thrombus resolution and chronic thromboembolic disease ... Role of angiopoietin-2 in venous thrombus resolution and chronic thromboembolic disease ... Role of angiopoietin-2 in venous thrombus resolution and chronic thromboembolic disease ...

https://erj.ersjournals.com/content/early/2021/04/19/13993003.04196-2020

Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of ... Active Comparator: Aflibercept 2 mg Participants were administered intravitreal injection of Aflibercept (IAI) 2 mg Q4 on Day 1 ... Experimental: Aflibercept 2 mg Q4 to REGN910-3 (6 mg:2 mg) Q8 Participants were administered intravitreal injection of ... Experimental: Aflibercept 2 mg Q4 to Aflibercept 2 mg Q8 Participants were administered intravitreal injection of Aflibercept ( ...

https://clinicaltrials.gov/ct2/show/NCT02712008?term=r910-3-dme-1518&rank=1

The angiopoietin family of proteins includes four different angiopoietins termed Ang-1 through Ang-4 (Yancopoulos et al., 2000 ... Biological characterization of angiopoietin-3 and angiopoietin-4. FASEB J 18: 1200-1208. ... B, angiopoietins administered at 300 ng/paw, and edema measured up to 4 h. Values are mean + S.E.M.; n = 8 mice; *, p , 0.05 ... Because of its interaction with the angiopoietins during angiogenesis, we sought to determine whether angiopoietins modify VEGF ...

http://jpet.aspetjournals.org/content/314/2/738

Angiopoietin-2 (Ang-2) is involved in angiogenesis in both solid and hematological malignancies. In Multiple Myeloma (MM), ... Notably, Ang-2 but not VEGF serum levels correlated with BM micro-vessel density, further underscoring the key role of Ang-2 in ... These data suggest that Ang-2 produced in the BM milieu may contribute to MM angiogenesis and suggest that the molecule can be ... To address the patho-physiologic role of Ang-2 in MM associated angiogenesis, we used sera from patients with active MM, which ...

https://insights.ovid.com/excer/201501000/00076208-201501000-00001

The Role of the Angiopoietin/Tie-2 System in Retinal Neovascularisation You will receive an email whenever this article is ... O Nalovina, J Cai, P Hykin, M Boulton; The Role of the Angiopoietin/Tie-2 System in Retinal Neovascularisation . Invest. ... The findings indicate that the Angiopoietin system may play a role in retinal neovascularisation via the Tie-2 receptor, which ... Ang-2 was only weakly mitogenic for pericytes (20% increase in cell number), meantime Ang-1 had no effect. Ang-1 led to a ...

https://iovs.arvojournals.org/article.aspx?articleid=2418590

We also tested the association of concentration of angiopoietin-2 relative to ang ... To test the hypothesis that the concentration of angiopoietin-2 relative to angiopoietin-1 may be a useful biological marker of ... Angiopoietin-1 / blood*. Angiopoietin-2 / blood*. Biological Markers / blood*. Enzyme-Linked Immunosorbent Assay. Female. ... MEASUREMENTS AND MAIN RESULTS: Plasma levels of angiopoietin-1 and angiopoietin-2 and of biomarkers of endothelial activation ...

http://www.biomedsearch.com/nih/Ratio-angiopoietin-2-to-1/20581666.html

Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. (jci.org)
107 Angiopoietin 2 (ANGPT2) Antikörper von 17 Herstellern verfügbar auf www.antikoerper-online.de. (antikoerper-online.de)
171 Angiopoietin 2 (ANGPT2) Antibodies from 26 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation (1, 2). (rndsystems.com)
Angiopoietin-2 (ANGPT2) has been shown to regulate angiogenesis, but its importance for thrombus resolution and remodelling is unknown. (ersjournals.com)
Follow-up association analysis identified two haplotypes in angiopoietin-2 (ANGPT2) that significantly contributed to the variation of SaO 2 (P=8×10 -5 ) and accounted for a portion of the linkage evidence. (elsevier.com)
Gene-based association analysis replicated the association of ANGPT2 and nocturnal SaO 2 . (elsevier.com)
A rare missense SNP rs200291021 in ANGPT2 was associated with serum angiopoietin-2 level (P=1.29×10 -4 ), which was associated with SaO 2 (P=0.002). (elsevier.com)
Our study provides the first evidence for the association of ANGPT2, a gene previously implicated in acute lung injury syndromes, with nocturnal SaO 2 , suggesting that this gene has a broad range of effects on gas exchange, including influencing oxygenation during sleep. (elsevier.com)
Angiopoietin 2 (ANGPT2)- Cloud-Clone Corp. (cloud-clone.com)
Rabbit IgG polyclonal antibody for Angiopoietin-2(ANGPT2) detection. (bosterbio.com)
ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. (bosterbio.com)
ELISA Genie Human Angiopoietin-2 (ANGPT2) ELISA KitThe ELISA Genie Human Angiopoietin-2 (ANGPT2) ELISA Kit can assay for Human Angiopoietin-2 in the following samples: serum, blood, plasma, cell. (elisagenie.com)
Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Angiopoietin 2 (ANGPT2) were tested 20 times on one plate, respectively. (biomatik.com)
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Angiopoietin 2 (ANGPT2) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
This assay has high sensitivity and excellent specificity for detection of Angiopoietin 2 (ANGPT2). (biomatik.com)
The microtiter plate provided in this kit has been pre-coated with an antibody specific to Angiopoietin 2 (ANGPT2). (biomatik.com)
Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Angiopoietin 2 (ANGPT2). (biomatik.com)
After TMB substrate solution is added, only those wells that contain Angiopoietin 2 (ANGPT2), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (biomatik.com)
The concentration of Angiopoietin 2 (ANGPT2) in the samples is then determined by comparing the O.D. of the samples to the standard curve. (biomatik.com)
Angiopoietin-2 (ANGPT2) is an immune target in patients and is involved in resistance to anti-VEGF treatment with the monoclonal antibody bevacizumab. (aacrjournals.org)

Here, we report that angiopoietin-2 (Ang2), a known growth factor, is capable of promoting breast cancer cell invasion leading to metastasis. (aacrjournals.org)
Angiopoietins (Ang1 and Ang2) are ligands for an endothelial cell-specific tyrosine kinase receptor, Tie2, and are important regulators of angiogenesis and tumor progression ( 13 ). (aacrjournals.org)
In our study, the expression of Angiopoietin-1 (ANG1) and Angiopoietin-2 (ANG2) mRNA in archival human breast cancer tumor samples and in 6 breast cancer cell lines was investigated. (nih.gov)
20) Angiopoietin 2 (Ang2) and vascular EGF (VEGF) inductions correlate remarkably well with this process. (thefreedictionary.com)
Purpose To define proangiogenic angiopoietin 2 (ANG2) expression and role(s) in human and mouse vascularised corneas. (bmj.com)
After 2 or 10 days the corneas were removed and immunostained for collagen IV, ANG2, CD31, LYVE1, CD11b and MRC1 markers. (bmj.com)
Angiopoietin-2 (Ang2), a known angiogenic protein, was found to be downregulated by LS both in cultured ECs and mouse aortas. (ahajournals.org)
From these and subsequent functional studies, we demonstrate that LS inhibits angiogenesis through the downregulation of Angiopoietin-2 (Ang2), a secreted protein that is required for postnatal angiogenesis. (ahajournals.org)
AMG 780 is a mAb that binds to angiopoietin-1 and -2 (Ang1 and Ang2), preventing their binding to the Tie2 receptor to suppress angiogenesis. (aacrjournals.org)
The angiopoietin axis is a distinct angiogenic pathway that activates complementary angiogenic processes through binding of the ligands angiopoietin-1 and -2 (Ang1 and Ang2) to the tyrosine kinase receptor Tie2 ( 1 ). (aacrjournals.org)
The development and progression of lung cancer is stimulated by angiopoietin-2 (Ang2), a ligand for Tie2, an endothelial tyrosine kinase. (jcancer.org)
Angiopoietin-2 (Ang2) is a 75-kDa protein expressed in endothelium that is localized to human chromosomes 8p23.1 and first defined at sites of vascular remodeling [ 5 ]. (jcancer.org)
In sepsis and various other inflammatory conditions, elevated circulating levels of angiopoietin-2 (Ang2) are detected, but the precise functional role of Ang2 in these conditions is not well understood. (oup.com)
Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. (acrobiosystems.com)
We previously reported that angiopoietin-2 (Ang2), an angiogenic regulator stimulates MCF-7 breast tumor metastasis from their orthotopic sites to distant organs through the α5β1 integrin/integrin-linked kinase (ILK)/Akt pathway. (northwestern.edu)
We show that Ang2 increases cell survival and suppresses cell apoptosis through ILK-induced phosphorylation of Akt1, Akt2, and up-regulation of Bcl-2 in breast cancer cells. (northwestern.edu)
Inhibition of ILK, Akt1, and Akt2, and their effector Bcl-2 diminishes Ang2-stimulated breast cancer cell survival and Ang2-attenuated apoptosis in vitro, and initial survival and growth of breast cancer metastasis in the lung of animals. (northwestern.edu)
Additionally, siRNA knockdown of endogenous Ang2 in three human metastatic breast cancer cell lines also inhibits phosphorylation of Akt, expression of Bcl-2, and tumor cell survival, migration, and increases cell apoptosis. (northwestern.edu)
The Tie2 receptor has been implicated in stabilization and maturation of vessels through action of an agonist ligand, angiopoietin 1 ( Ang1) and an antagonistic ligand, Ang2. (wikigenes.org)
Suppression of neo-angiogenesis is a clinically used anti-tumor strategy with new targets such as angiopoietin-2 (Ang2) being proposed. (ox.ac.uk)

Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene. (wikipedia.org)
Angiopoietin-like protein 2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas an excess of ANGPTL2 activation induced by prolonged stress promotes the breakdown of tissue homeostasis due to chronic inflammation, promoting the development of metabolic diseases. (wikipedia.org)
ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. (wikipedia.org)
Molecular cloning, expression, and characterization of angiopoietin-related protein. (wikipedia.org)
A gene on chromosome 8q23.1 that encodes angiopoietin 2, a secreted glycoprotein which, like other angiopoietins, binds to endothelial cell-specific tyrosine-protein kinase receptor. (thefreedictionary.com)
To examine the roles of angiopoietin like protein 2 (Angptl2) in corneal neovascularization using transgenic mice expressing Angptl2 driven by cytokeratin 14 (K14, K14-Angptl2 mice). (arvojournals.org)
Anti-Angiopoietin-2, rabbit polyclonal, recognizes the ~55 kDa non-glycosylated and the ~70 kDa glycosylated, secreted Ang-2 protein. (emdmillipore.com)
Recognizes both the ~55 kDa non-glycosylated and the ~70 kDa glycosylated, secreted Ang-2 protein in cell culture medium. (emdmillipore.com)
The immunogenic peptide sequence is 71% (15/21 amino acids) conserved in the human angiopoietin-2 protein. (emdmillipore.com)
Erkan G, Muratoglu S, Ercin U, Bilgihan A. Angiopoietin-like protein 2 and angiopoietin-like protein 6 levels in patients with nonalcoholic fatty liver disease. (termedia.pl)
The aim of the current study was to examine the difference between patients detected with nonalcoholic fatty liver disease (NAFLD) and healthy subjects in terms of serum angiopoietin-like protein (ANGPTL) 2 and ANGPTL6 levels and to evaluate the correlation between ANGPTL2 and ANGPTL6 levels and liver enzyme levels, fasting glucose, lipid levels, and steatosis degree on ultrasonography (USG). (termedia.pl)
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. (termedia.pl)
MBS281858 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Angiopoietin-like protein 2 (ANGPTL2) ELISA Kit target analytes in biological samples. (mybiosource.com)
Intended Uses: For the quantitative detection of Human Angiopoietin-like protein 2 (ANGPTL2) concentration in serum, plasma and other biological fluids. (mybiosource.com)
In this study, we investigated a novel role of non-receptor protein tyrosine phosphatase N-2 (PTPN-2) in Ang-1 mediated stabilization of tight junction proteins. (northwestern.edu)
E.coli-derived human Angiopoietin 2 recombinant protein (Position: Y19-N348). (bosterbio.com)
Therefore, utilizing the HBc antigen protein as a platform of vaccine, attempts have been made to induce production of the antibody even though an antigen is difficult to be recognized by the immune system (non-patent document 1, non-patent document 2). (justia.com)
There are 9 Angiopoietin-2 protein produced in house with high quality which are covering various species. (sinobiological.com)
Among these Angiopoietin-2 proteins, there are 5 Human Angiopoietin-2 protein, 1 Mouse Angiopoietin-2 protein, 1 Canine Angiopoietin-2 protein, 2 Cynomolgus Angiopoietin-2 protein. (sinobiological.com)
All these Angiopoietin-2 protein are expressed by different host cells. (sinobiological.com)
Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling. (nih.gov)
Angiopoietin-like protein 2 (ANGPTL2) induces expression of anti-apoptotic BCL-2 family members. (nih.gov)
Should the Human Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (gentaur.se)
Description: A sandwich quantitative ELISA assay kit for detection of Human Angiopoietin Like Protein 2 (ANGPTL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (gentaur.se)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiopoietin Like Protein 2 (ANGPTL2) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (gentaur.se)
Objective - Angiopoietin-like protein 2 (ANGPTL2), a proinflammatory mediator, has been reported to accelerate the development of insulin resistance, endothelial dysfunction, and atherosclerosis in mice. (elsevier.com)
The angiopoietin-like 4 (ANGPTL4) protein belongs to a superfamily of secreted proteins structurally related to factors modulating angiogenesis known as angiopoietins. (hindawi.com)
All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. (wikipedia.org)
Angiopoietin-like protein 2 (ANGPTL2) is a secreted protein belonging to the angiopoietin family, the members of which are implicated in various biological processes, although its receptor remains unknown. (elsevier.com)
Angiopoietin-like protein 2 (Angptl2) is a mediator of chronic inflammation that contributes to extracellular matrix remodeling. (biomedcentral.com)
To determine whether angiopoietin-like protein 2 (ANGPTL2) is highly expressed in the hyperplastic facet joint (FJ) synovium and whether it activates interleukin-6 ( IL-6 ) secretion in FJ synoviocytes . (bvsalud.org)
Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. (eiaab.com)

An Angiopoietin-2 specific rat monoclonal antibody has been precoated onto 96-well plates. (abcam.com)
A biotinylated detection polyclonal antibody from goat, specific for Angiopoietin-2 is then added followed by washing with PBS or TBS buffer. (abcam.com)
We offer Angiopoietin-2 Antibodies for use in common research applications: ELISA, ELISA Capture (Matched Antibody Pair), ELISA Detection (Matched Antibody Pair), ELISA Standard (Matched Pair), Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot. (novusbio.com)
Each Angiopoietin-2 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
Choose from our Angiopoietin-2 polyclonal antibodies and browse our Angiopoietin-2 monoclonal antibody catalog. (novusbio.com)
RG7716 is the first bispecific, monoclonal antibody specifically designed for the eye that simultaneously binds to and inactivates vascular endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2). (chemdiv.com)
For the first time in diabetic macular edema, a clinically meaningful and statistically significant improvement in visual acuity compared to anti-VEGF alone has been demonstrated by simultaneously neutralising both angiopoietin-2 and VEGF-A with a bispecific antibody," said Sandra Horning, MD, Chief Medical Officer and Head of Global Product Development. (chemdiv.com)
We previously showed that circulating Ang-2 correlated with disease severity in a small cohort of critically ill patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. (elsevier.com)
2. A combination according to claim 1 wherein the antagonist of Angiopoietin-2 is an antibody. (patentsencyclopedia.com)

Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2 ," Annals of the Rheumatic Diseases, vol. (thefreedictionary.com)
Angiopoietin-2 (Ang-2) is involved in angiogenesis in both solid and hematological malignancies. (ovid.com)
To address the patho-physiologic role of Ang-2 in MM associated angiogenesis, we used sera from patients with active MM, which contained significantly higher levels of the molecule, compared to those from patients with smoldering MM and Monoclonal Gammopathy of Undetermined Significance. (ovid.com)
Notably, Ang-2 but not VEGF serum levels correlated with BM micro-vessel density, further underscoring the key role of Ang-2 in angiogenesis. (ovid.com)
These data suggest that Ang-2 produced in the BM milieu may contribute to MM angiogenesis and suggest that the molecule can be further exploited both as angiogenesis biomarker and as a potential therapeutic target. (ovid.com)
The findings indicate that the Angiopoietin system may play a role in retinal neovascularisation via the Tie-2 receptor, which may be partially due to an increase in endothelial cells motility, a key step of angiogenesis. (arvojournals.org)
We hypothesized that LS inhibits EC migration and tubule formation, 2 functions important in angiogenesis, by inhibiting the secretion of proangiogenic factors. (ahajournals.org)
The angiopoietin axis plays an important role in angiogenesis and is distinct from currently approved angiogenesis inhibitors which target the VEGF pathway. (aacrjournals.org)
VEGF pathway family members play a critical role in angiogenesis by stimulating proliferation, migration, and survival of endothelial cells ( 2 ). (aacrjournals.org)
Practical application of the sensor was demonstrated by detecting a specific glycoprotein, Angio-poietin 2, that is involved in angiogenesis and inflammation processes. (fraunhofer.de)
However, its transcriptional regulation is rather moderate compared with other angiogenesis-regulating molecules such as VEGF and Angiopoietin-2 (Ang-2). (biologists.org)
However, other growth factors also have a major role in angiogenesis, such as those of the angiopoietin family (e.g. (onlinejacc.org)
More recently, oncology research has identified other growth factors, such as those of the angiopoietin (Ang) family, that appear to have a major role in angiogenesis and metastasis (2-4) . (onlinejacc.org)
Ang-2 has been implicated in cancer development due to its role in angiogenesis.Ang-2-mediated destabilization of mature vessel structures accompanied by the presence of VEGF, may contribute to the angiogenesis associated with tumor tissues. (cloud-clone.com)
As the tumor angiogenesis-related factor, various factors such as VEGF, angiopoietin, FGF, PDGF and the like are known. (justia.com)
For example, patent document 1 discloses a method of inhibiting vascular endothelial cell proliferation in a tumor microenvironment, preventing angiogenesis and inhibiting growth and metastasis of tumor, by administering a DNA vaccine encoding VEGF receptor-1, VEGF receptor-2 or Flk-1. (justia.com)
Patent document 2 describes suppression of angiogenesis-related diseases, particularly of the development and metastasis of cancer, by using heterologous VEGF vaccines. (justia.com)
Background and Objective: Angiopoietin-2 (Ang-2) is an important mediator of angiogenesis and has been implicated in many inflammatory diseases. (northumbria.ac.uk)
Angiopoietins are proteins with important roles in vascular development and angiogenesis. (wikipedia.org)
Angiopoietins, Ang-1, Ang-2, and Ang-3 (mouse)/Ang-4 (human), are natural agonists or antagonists of the Tie-2 receptor tyrosine kinase and are important modulators of angiogenesis. (novusbio.com)
Conclusion The effect of angiopoietin-2 and endostatin in angiogenesis of endometriosis are important play a role in pathogenesis and development of the endometriosis. (bvsalud.org)
Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. (elsevier.com)
In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis. (elsevier.com)
G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency. (ox.ac.uk)

Serum Angptl2 levels are independently associated with albuminuria in type 2 diabetes. (termedia.pl)
Apoptosis induced by antineoplastic drug treatment was significantly decreased in SW480/ANGPTL2 compared to control cells.Expression of anti-apoptotic BCL-2 family genes was upregulated in SW480/ANGPTL2 compared to SW480/Ctrl cells.To assess signaling downstream of ANGPTL2 underlying this effect, we carried out RNA sequencing analysis of SW480/ANGPTL2 and SW480/Ctrl cells. (nih.gov)
a) Relative mRNA expression of the anti-apoptotic BCL-2 family members BCL-2 (left) and BCL-XL (middle) and of pro-apoptotic BAX (right) in SW480/ANGPTL2-1, SW480/ANGPTL2-2, or SW480/Ctrl cells. (nih.gov)
19) Therefore, we examined the expression of BCL-2 family mRNAs in SW480/ANGPTL2-1 and -2 cells or SW480/Ctrl cells. (nih.gov)
19,20) Therefore, we analyzed that ratio in SW480/ANGPTL2-1, SW480/ANGPTL2-2, and SW480/Ctrl cells and found that BCL-2/BAX and BCL-XL/BAX ratios were greater in both ANGPTL2-overexpressing lines than they were in controls (Fig. 2b). (nih.gov)
ANGPTL2 mRNA expression was observed in normal ovarian tissue and immortalized normal ovarian epithelial cells, but was reduced in some OC lines without its homozygous deletion (18 of 23 lines) and restored after treatment with 5-aza 2′-deoxycytidine. (elsevier.com)
Angiopoietin-like-2 (angptl2) is produced by several cell types including endothelial cells, adipocytes and macrophages, and contributes to the inflammatory process in cardiovascular diseases. (certara.com)

Immunoblotting suggested an increase of total and tyrosine-phosphorylated Tie-2 proteins in null mutant versus wild-type kidneys, and electron microscopy confirmed disorganized capillaries and adjacent cells in cortical peritubular spaces in mutant neonate kidneys. (nih.gov)
A hallmark of acquisition of cell motility by tumor cells is the functional loss of E-cadherin and expression of mesenchymal proteins, such as α-smooth muscle actin and vimentin, which defines the key steps toward the invasive phase of breast cancers ( 2 ). (aacrjournals.org)
Kadomatsu T, Tabata M, Oike Y. Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases. (termedia.pl)
Ang-2 contains an N-terminal coiled-coildomain, 58 - 254 amino acids (aa) and a C-terminal fibrinogen-like domain, 281 - 467 aa, that is also found in other proteins including fibrinogen, tenascin, and ficolin. (cloud-clone.com)
These Angiopoietin-2 proteins are produced with different tags, such as His Tag, Fc Tag. (sinobiological.com)
11) It is comprised of both pro- and anti-apoptotic proteins, and the latter (BCL-2, BCL-XL and MCL-1) reportedly inhibit 5-FU-induced apoptosis in CRC cells. (nih.gov)
Treatment of MDA-MB-231 cells with MSeA caused significant reduction of Ang-2 mRNA transcripts and secretion of Ang-2 proteins by the cells. (biomedcentral.com)
Two domains characterize the angiopoietin family of proteins: an N-terminal coiled-coil domain that mediates homo-oligomerization, and a C-terminal fibrinogen-like domain that binds Tie-2. (novusbio.com)
Biomarkers of particular interest have included interleukins (IL-6 and IL-8), interferon gamma (IFN-γ), surfactant proteins (SPD and SPB), von Willebrand factor antigen, angiopoietin 1/2 and plasminogen activator inhibitor-1 (PAI-1). (springer.com)

Abcam's mouse Angiopoietin-2 in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate quantitative measurement of mouse Angiopoietin-2 in cell culture supernatants, serum and plasma (heparin, EDTA). (abcam.com)
MEASUREMENTS AND MAIN RESULTS: Plasma levels of angiopoietin-1 and angiopoietin-2 and of biomarkers of endothelial activation were measured by enzyme-linked immunosorbent assay. (biomedsearch.com)
Citrated plasma was analyzed for Ang-1, Ang-2, tie-2, and VEGF by enzyme-linked immunosorbent assay. (onlinejacc.org)
Quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay were performed for endothelial adhesion molecules (P-selectin, E-selectin, VCAM-1 and ICAM-1) and plasma cytokines (TNF-α, IL-6, KC, MIP-2), respectively. (oup.com)
Serum concentrations of Angiopoietin-1, Angiopoietin-2, vascular endothelial growth factor (VEGF) and osteopontin were assessed by the enzyme-linked immunosorbent assay. (biomedcentral.com)
Admission levels of angiopoietin-1, angiopoietin-2, and a soluble version of their cognate receptor were measured by enzyme-linked immunosorbent assay. (lstmed.ac.uk)

Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. (abcam.com)
Reducing vascular leakage and stabilizing the endothelium through activation of the angiopoietin (ANGPT)-TIE2 receptor tyrosine kinase pathway is a promising therapeutic strategy for vascular diseases. (pnas.org)
Angiopoietin 2 and angiopoietin 1 are closely related endothelial cell-specific ligands of the endothelial cellspecific receptor Tie2 expressed on endothelial cells and early hematopoietic cells. (genetex.com)
Angiopoietin 2 probably acts as a natural antagonist for Ang1 and Tie2 both in vivo and in vitro. (genetex.com)
To assess the toxicity, pharmacokinetics, tumor vascular response, tumor response, and pharmacodynamics of AMG 780, a mAb designed to inhibit the interaction between angiopoietin-1 and -2 and the Tie2 receptor. (aacrjournals.org)
The endothelial-specific Angiopoietin-Tie2 ligand-receptor system is an important regulator of endothelial activation. (elsevier.com)
Binding of angiopoietin-2 (Ang-2) to Tie2 receptor renders the endothelial barrier responsive to pro-inflammatory cytokines. (elsevier.com)
Our results point out that MSeA exerts its anti-tumor effects, at least in part, by inhibiting the Ang-2/Tie2 pathway, probably via inhibiting VEGF. (biomedcentral.com)

Angiopoietins (Angs) are endothelium-selective ligands that exert most of their actions through the Tie-2 receptor. (aspetjournals.org)
The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the endothelial receptor tyrosine kinase Tie-2, which controls vascular assembly and endothelial quiescence. (biologists.org)
The Tie receptors and their angiopoietin (Ang) ligands have important functions during embryonic vessel assembly and maturation and control adult vascular homeostasis. (nature.com)
The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr kinase system. (nature.com)
Figure 3: Structural properties of the Tie receptors and the Angiopoietin ligands. (nature.com)
Although these three members show a significant homology, they differ from each other for tissue distribution, affinity for ligands, and biological functions [ 2 ]. (hindawi.com)

Most studies have reported vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), and angiopoietin 2 (Ang-2) to be potent regulators of microvascular remodelling in health and atherosclerotic diseases [8]. (thefreedictionary.com)
Furthermore, the expression levels of vascular endothelial growth factor (VEGF) and angiopoietin‑2 (Ang‑2) were significantly decreased in HYXZ‑treated groups compared with the model group. (spandidos-publications.com)
The effectiveness of HYXZ may be partially attributed to the decrease of VEGF and Ang‑2 expression levels in the ectopic endometrium. (spandidos-publications.com)
Vanucizumab is an investigational antiangiogenic, first-in-class, bispecific mAb targeting VEGF-A and angiopoietin-2 (Ang-2). (aacrjournals.org)
The roles of two members of this family, Ang-1 and Ang-2, are becoming understood and may act alongside VEGF. (onlinejacc.org)
Unlike VEGF, Ang-1 and Ang-2 do not have mitogenic/proliferative properties. (onlinejacc.org)
In epidemiological studies, raised VEGF, Ang-2, Tie-2 but not Ang-1 have been demonstrated in patients after ACS. (biomedcentral.com)
The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide. (justia.com)
The angiogenic factors, angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) are modulators of endothelial activation, with Ang-2 release from Weibel-Palade bodies (WPBs) being regulated by endothelial nitric oxide (NO). We explored the relationships between endothelial NO bioavailability, Ang-2, VEGF, tissue perfusion, and clinical outcomes in SM. (mysciencework.com)
We measured plasma Ang-2 and VEGF, together with biomarkers of severity from 146 adults with and without SM, in parallel with longitudinal measures of endothelial function by using reactive hyperemia peripheral arterial tonometry (a measure of endothelial NO bioavailability). (mysciencework.com)
Regression was used to relate concentrations of Ang-2/VEGF with malaria disease severity, biomarkers of perfusion, endothelial activation, and parasite biomass. (mysciencework.com)
The aim of the study was to compare serum levels of proangiogenic factors: Angiopoietin-1, Angiopoietin-2, VEGF and osteopontin in asthmatic patients and in healthy subjects (HS), and to refer their concentrations to the severity of asthma, clinical asthma phenotypes and inflammatory markers in serum. (biomedcentral.com)
We investigated levels of Ang-2 and vascular endothelial growth factor (VEGF) on the estrogen-independent bone metastatic mammary cancer (MDA-MB-231) cells in response to treatment by methylseleninic acid (MSeA), and further examined the effects of MSeA oral administration on xenograft mammary tumors of athymic nude mice by RT-PCR, Western, radioimmuno assay, and Immunohistochemistry. (biomedcentral.com)
During pregnancy, angiopoietins act complementary to the VEGF system and contribute to endothelial cell survival and the remodeling of vessels. (wikipedia.org)
More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists. (patentsencyclopedia.com)
Such combinations are also useful for the treatment of diseases associated with the activity of Angiopoietin-2 and VEGF-A, and/or KDR, and/or Flt1. (patentsencyclopedia.com)

Ang-2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. (rndsystems.com)
While Ang-2 is widely expressed in the mouse embryo, it is restricted postnatally to pro-angiogenic regions including the placenta, ovaries, and uterus. (cloud-clone.com)

It associates into dimers, trimers, and larger multimers and binds the receptor Tie-2, with its function as an agonist or antagonist depending on its state of multimerization. (rndsystems.com)
In contrast, the role of Ang-2 remains less clear because it has been shown to behave as a Tie-2 agonist or antagonist under different experimental conditions. (aspetjournals.org)
thus, Ang-2 is referred to as a context-dependent antagonist. (aspetjournals.org)
The largely complementary phenotypes of Ang-1-deficient mice and Ang-2-overexpressing mice have led to an antagonistic model in which Ang-1 acts as Tie-2-activating agonist and Ang-2 acts as a Tie-2-inhibiting antagonist. (biologists.org)
Ang-2 has been identified as a functional antagonist of Ang-1. (biologists.org)
1. A combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of i. (patentsencyclopedia.com)

Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release," Journal of Vascular Surgery, no. (thefreedictionary.com)
To define the role of Ang-2 in acute inflammation, we studied the effects of recombinant Ang-2 administration in vivo. (aspetjournals.org)
We conclude that Ang-2 by itself stimulates the extravasation of cell-poor fluid, but in the presence of ongoing inflammation it reduces cellular infiltration in tissues. (aspetjournals.org)
Ang-2 correlated weakly with BVAS/WG score (r = 0.17), moderately with markers of systemic inflammation (r = 0.25-0.41), and inversely with renal function (r = -0.36). (elsevier.com)
In one study, involving a small group of subjects elevated serum angiopoietins levels were found in asthma patients and have been associated with decreased lung function [ 16 ], suggesting that the serum level of proangiogenic factors may reflect ongoing asthmatic inflammation and serve as a potential biomarker of the disease severity. (biomedcentral.com)

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1. (wikipedia.org)

The newborn neoplastic vasculature is aberrant and incomplete with distorted, dilated, and leaky vessels, insufficient pericyte coverage, abnormal endothelial cell proliferation, an uneven distribution within cancer tissues, and wide fenestrations that ultimately contribute to tumor cell sprouting through the vascular flow ( 2 - 5 ). (frontiersin.org)
FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development , [2] cell growth, morphogenesis , tissue repair, tumor growth and invasion. (wikipedia.org)

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. (wikipedia.org)
In hypoxic conditions, expression of hypoxia inducible factoralpha increases rapidly which in turn activates genes that encode for proangiogenic growth factors, such as vascular endothelial growth factor, basic fibroblast growth factor, angiopoietin 1 and angiopoietin 2 , placental growth factor, and platelet-derived growth factor-B [29]. (thefreedictionary.com)
Exogenous Ang-2-mediated endothelial-cell detachment can be rescued by Ang-1, soluble Tie-2 and vascular endothelial growth factor. (biologists.org)
Thus, stimulated release of endogenous Ang-2 or overexpression of Ang-2 in endothelial cells perturbs co-culture spheroid integrity, which can be rescued by exogenous Ang-1 and vascular endothelial growth factor. (biologists.org)

Recombinant human angiopoietin 2 has a molecular mass of approximately 66 kDa in SDS-PAGE under reducing and non-reducing conditions. (genetex.com)
Purified recombinant human angiopoietin-2 expressed in mouse NSO cells. (genetex.com)
0.2 μg/mL of Recombinant Human Angiopoietin‑2 significantly induces phosphorylation of human Tie-2. (rndsystems.com)
When Recombinant Human Tie-2 Fc Chimera (Catalog # 313-TI) is immobilized at 0.5 µg/mL (100 µL/well), Recombinant Human Angiopoietin‑2 (Catalog # 623-AN ) binds with an ED 50 of 0.5-4 ng/mL. (rndsystems.com)
It contains NS0-expressed recombinant human Angiopoietin-1 and has been shown to accurately quantitate the recombinant factor. (novusbio.com)

Our Angiopoietin-2 Antibodies can be used in a variety of model species: Chicken, Human, Mouse. (novusbio.com)
The expression of the Tie-2 receptor in cultured BRMEC and pericytes was analysed by immunoprecipitation with corresponding antibodies and Western blotting. (arvojournals.org)
The present invention relates to antibodies against angiopoietins 1 and 2, and derivatives of these antibodies. (patentsencyclopedia.com)
More specifically, the present invention relates to therapeutic use of the antibodies and fragment thereof which specifically bind to angiopoietins 1 and 2. (patentsencyclopedia.com)

We also tested the association of concentration of angiopoietin-2 relative to angiopoietin-1 with physiologic and biological markers of activated endothelium. (biomedsearch.com)
Taken together, the data demonstrate for the first time the antagonistic Ang-1/Ang-2 concept in a defined cellular model and identify Ang-2 as a rapidly acting autocrine regulator of the endothelium that acts through an internal autocrine loop mechanism. (biologists.org)
CONCLUSIONS: The independent prognostic significance of Ang-2 and the Ang-2/Ang-1 ratio in severe malaria was confirmed, although immunohistochemistry in fatal cases did not reveal increased expression on brain endothelium in cerebral versus non-cerebral cases. (ox.ac.uk)

The current study addresses this issue, focusing on angiopoietin 2 (Ang-2) and endothelial cell-specific molecule-1 (endocan) in ARDS patients. (thefreedictionary.com)
To investigate the predictive value of the acute physiology and chronic health evaluation 2 (APACHE2) score and lung injury prediction score (LIPS) for acute respiratory distress syndrome (ARDS) when combined with biomarkers for this condition in patients with ARDS risk factors. (hindawi.com)
The LIPS, APACHE2 score, primary diagnosis at admission, and ARDS risk factors were determined within 6 h of admission, and PaO 2 /FiO 2 was determined on the day of admission. (hindawi.com)
Plasma ANG-2 level, sE-selectin level, LIPS, and APACHE2 score in ARDS patients were significantly higher than those in non-ARDS patients. (hindawi.com)
When the APACHE2 score was used in combination with the LIPS and ANG-2 level to predict ARDS, the area under the ROC curve (AUC) was not significantly increased. (hindawi.com)
Compared to LIPS or ANG-2 alone, LIPS in combination with ANG-2 had significantly increased positive predictive value (PPV) and AUC for the prediction of ARDS. (hindawi.com)
In conclusion, plasma ANG-2 level, LIPS, and APACHE2 score are correlated with ARDS. (hindawi.com)
Combined LIPS and ANG-2 level displays favorable sensitivity, specificity, and AUC for the prediction of ARDS. (hindawi.com)
Although great progress has been made in the methods used to improve the clinical prognosis of ARDS (such as the use of protective mechanical ventilation [ 2 - 4 ] and fluid balance therapy [ 5 ]), the morbidity and mortality of ARDS remain largely unchanged. (hindawi.com)
Serum ANG-2 level is significantly increased in ARDS patients [ 18 , 19 ], and ANG-2 displays predictive value for ARDS [ 19 , 20 ]. (hindawi.com)

CONCLUSIONS: The ratio of concentration of angiopoietin-2 relative to angiopoietin-1 may be a prognostic biomarker of endothelial activation in acute lung injury patients and, along with pulmonary dead-space fraction, may be useful for risk stratification of acute lung injury patients, particularly in identifying subgroups for future research and therapeutic trials. (biomedsearch.com)
Our data support a role of Ang-2 as a biomarker of incident AMI independent of traditional risk factors. (biomedcentral.com)
The current study reassessed Ang-2 as a biomarker of disease activity and relapse in AAV. (elsevier.com)
Thus, Ang-2 appears to have limited practical value in AAV as a biomarker of disease activity at time of measurement or for predicting future activity. (elsevier.com)
Angiopoietin-2 seems to be a crucial proangiogenic cytokine overproduced in patients with SRA characterized by repeated exacerbations and Angiopoietin-2 serum levels can serve as a biomarker of severe asthma. (biomedcentral.com)
Serum Ang-2 may serve as a biomarker that could predict the outcome of a COPD exacerbation. (northumbria.ac.uk)
Our data provide the first evidence for a strong link between ANGPTL8 and subclinical atherosclerosis, suggesting ANGPTL8 to be a new biomarker for subclinical atherosclerosis in type 2 diabetes. (eiaab.com)

Objectives The goal of this research was to test the hypothesis that plasma angiopoietin (Ang-1), its soluble receptor tie-2, and Ang-2 levels would be abnormal in patients with acute and chronic congestive heart failure (CHF) when compared with healthy controls. (onlinejacc.org)
Ang-2 concentrations were elevated in SM and associated with increased venous lactate, plasma intercellular cell adhesion molecule-1 concentrations, parasite biomass, and mortality. (mysciencework.com)
BACKGROUND: Plasma angiopoietin (Ang)-2 is associated with disease severity and mortality in adults and children with falciparum malaria. (ox.ac.uk)
This study aimed to determine whether the expression of Ang-1 and Ang-2 and their receptor Tie-2 in cerebral endothelial or parenchymal cells was specific to cerebral malaria (CM), correlated with coma or other severe clinical features, and whether plasma and CSF levels of these markers correlated with the clinical and neuropathological features of severe and fatal malaria in Vietnamese adults. (ox.ac.uk)
Quantitative ELISA for plasma and cerebrospinal fluid levels of Ang-1, Ang-2 and Tie-2 was done to compare fatal cases with surviving patients from the same study. (ox.ac.uk)
Plasma levels of Ang-2 and Ang-2/Ang-1 ratio were associated with the number of severe malaria complications and were significant and independent predictors of metabolic acidosis and fatal outcome. (ox.ac.uk)
The Quantikine Human Angiopoietin-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Angiopoietin-1 in cell culture supernates, serum, plasma, saliva, and human milk. (novusbio.com)
Plasma angiopoietin-2 (ANG-2) is a proinflammatory cytokine that can regulate endothelial permeability [ 17 ]. (hindawi.com)

MM Bone Marrow (BM) sera with high Ang-2 concentration specifically contributed to endothelial cell (EC) activation, while Ang-1 containing sera maintained EC stabilization. (ovid.com)
OBJECTIVE: To test the hypothesis that the concentration of angiopoietin-2 relative to angiopoietin-1 may be a useful biological marker of mortality in acute lung injury patients. (biomedsearch.com)
p = .01) in those with an elevated pulmonary dead-space fraction (p = .03 for interaction between pulmonary dead-space fraction and concentration of angiopoietin-2 relative to angiopoietin-1). (biomedsearch.com)
The protocol used for the label-free detection of Angiopoietin 2 is described, and the results of an exemplary assay, carried out at a relatively high concentration of 1 µg/ml, are given and confirm that an efficient detection can be achieved. (fraunhofer.de)
In peritoneal fluid,ANG-2 and ENS concentration and ratio of ANG-2/ENS in endometriosis were significantly higher than that in controls. (bvsalud.org)

Ang-2 release from endothelial cells with reduced NO bioavailability is likely to contribute to endothelial activation, sequestered parasite biomass, impaired perfusion, and poor outcome in severe falciparum malaria. (mysciencework.com)
Conclusions: These results provide insights into mechanisms of endothelial activation in cerebral malaria and indicate that the angiopoietin-Tie-2 axis is associated with retinopathy and mortality in pediatric cerebral malaria. (lstmed.ac.uk)

Under non‑reducing conditions, both natural and recombinant Ang-2 form 140 kDa dimers, 200 kDa trimers, and 250-300 kDa tetramers and pentamers (3-6). (rndsystems.com)

Angiopoietin-1 and -2 play modulatory roles by binding a common receptor, the endothelial cell-specific tyrosine kinase receptor tie-2. (onlinejacc.org)
Angiopoietin 1 has been shown to interact with TEK tyrosine kinase. (wikipedia.org)

Patients with unfavorable outcome had significantly higher Ang-2 levels both on D1 (p = 0.04) and D7 (p = 0.01). (northumbria.ac.uk)

However, when cell migration was elicited using zymosan, Ang-2 significantly inhibited leukocyte migration. (aspetjournals.org)
Furthermore, expression of the Tie-2 receptor on pericytes may allow their participation in the maintenance of capillary integrity, which is significantly disturbed, in diabetic retinopathy. (arvojournals.org)
Ang-2 concentrations were significantly better predictors of death than venous lactate (P = 0.03). (mysciencework.com)
However Ang-1 and Ang-2 expression in neurons was significantly correlated with the incidence of microscopic haemorrhages. (ox.ac.uk)
The concentrations of ANG-2 and ENS in peritoneal fluid were measured with enzyme linked immunoabsorbant assay.Results In the EMs group,ANG-2 positive rate in eutopic endometrium was significantly higher than that of ectopic endometrium. (bvsalud.org)
The ANG-2 positive rate in ectopic endometrium was significantly higher than that of control group;in EMs group,the ENS positive rate in ectopic endometrium was significantly higher than that in eutopic endometrium.The ENS positive rate in eutopic endometrium was significantly higher than that in control group. (bvsalud.org)
Serum levels of ANGPTL8 and triglyceride (TG) were significantly increased in type 2 diabetic patients with subclinical atherosclerosis as compared with type 2 diabetic patients without subclinical atherosclerosis and control subjects (P? (eiaab.com)

Angiopoietin-2 (Ang-2) is a secreted glycoprotein that plays a complex role in vascular development. (cloud-clone.com)

The limit of detection of the biochips for Angiopoietin 2, based on the protocol used, is 1.5 pg/mm2 in buffer solution. (fraunhofer.de)
The Human Angiopoietin-2 PharmaGenie ELISA Kit is an ELISA kit for the detection of Angiopoietin-2 in a range of sample types. (elisagenie.com)

In adult mice and humans, angiopoietin 2 is expressed at sites of vascular remodeling. (genetex.com)
The phenotype of angiopoietin- and Tie-2-deficient mice has been analysed in great detail, yet the molecular mechanisms of action and functional consequences of endothelial-cell activation through the angiopoietin/Tie-2 system are poorly understood. (biologists.org)
In a mouse model of PM, Plasmodium infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta. (wikipedia.org)
0.05) total cholesterol-to-high-density lipoprotein ratios, low-density lipoprotein-to-high-density lipoprotein ratios, and leptin levels in WT mice only, while glycemia remained similar in the 2 strains. (certara.com)

Western Blot, RT-PCR and immunocytochemistry identified MMEC as the major source of Ang-2, at variance with MM cells and CD14+ BM monocytes. (ovid.com)

The effect of Ang-2 is blocked by the coadministration with a soluble form of the Tie-2 receptor or Ang-1. (aspetjournals.org)
However, autocrine Ang-2-mediated endothelial-cell detachment cannot be blocked by soluble Tie-2. (biologists.org)
We show that angiopoietin-1 levels are decreased and angiopoietin-2 and soluble Tie-2 levels are increased in children with cerebral malaria who had retinopathy compared with those who did not. (lstmed.ac.uk)
soluble Tie-2, 9.7 [2.1-45.8], p = .004). (lstmed.ac.uk)
Angiopoietin-2 and soluble Tie-2 levels were elevated in children with cerebral malaria who subsequently died and angiopoetin-2 was an independent predictor of death (adjusted odds ratio: 3.9 [1.2-12.7], p = .024). (lstmed.ac.uk)

Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome," Shock, vol. (thefreedictionary.com)
Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. (biomedsearch.com)
In 2012, worldwide age-standardized mortality rates for males and females with lung cancer were 30.0/100,000 and 11.1/100,000, respectively, reflecting poor 5-year relative survival rates [ 2 ]. (jcancer.org)
Objective: To investigate the relationship among the angiopoietin-Tie-2 system, retinopathy, and mortality in children with cerebral malaria. (lstmed.ac.uk)
When combined with clinical parameters, angiopoetin-2 improved prediction of mortality using logistic regression models and classification trees. (lstmed.ac.uk)

The functional dichotomy of Ang-1 and Ang-2 was confirmed by the triggering of distinctive signaling pathways down-stream the common Tie-2 receptor, i.e., the Akt or the ERK- phosphorylation pathway. (ovid.com)
A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria. (ox.ac.uk)
Activation of the Ang-Tie-2 pathway in severe malaria is therefore related to acidosis, number of severity criteria and outcome, but is not a specific event in the brain during cerebral malaria. (ox.ac.uk)

Human and mouse angiopoietin 2 share 85% sequence identity and are 60% identical to their Ang1 homologs. (genetex.com)
Measured by its ability to activate Tie-2 in C6 rat glial cells transfected with human Tie-2. (rndsystems.com)
Methods and Results- Human umbilical vein ECs (HUVECs), human microvascular ECs (HMECs), or bovine aortic ECs (BAECs) were subjected to either LS (15 dyn/cm 2 ) or OS (±5 dyn/cm 2 ) for 24 hours and used in Matrigel tubule formation or scratch migration assays. (ahajournals.org)
Human umbilical vein endothelial cells (HUVECs), bovine aortic ECs (BAECs), and human microvascular EC line (HMEC-1) were grown to confluence and exposed to unidirectional LS (5 or 15 dyn/cm 2 ), OS (±5 or ±15 dyn/cm 2 at 1 Hz frequency), or static control (ST) for 24 hours using a cone-and-plate device as described by us. (ahajournals.org)
In this phase I first-in-human study in patients with advanced cancer, AMG 780 was administered once every 2 weeks at doses up to 30 mg/kg, with median terminal elimination half-life ranging from 8 to 13 days and evidence of reduced capillary blood flow. (aacrjournals.org)
No. TI2-H5255 ) at 2 μg/mL (100 μL/well) can bind Biotinylated Human Angiopoietin-2, His,Avitag (Cat. (acrobiosystems.com)
Human Angiopoietin 2 shares 84% and 85% amino acid (aa) sequences identity with mouse and rat Angiopoietin 2, respectively. (bosterbio.com)
Few studies have examined the role of angiopoietins in human pregnancy complications like preeclampsia and intrauterine growth restriction (IUGR). (wikipedia.org)
Results obtained using natural human Angiopoietin-1 showed linear curves that w ... ere parallel to the standard curves obtained using the Quantikine kit standards. (novusbio.com)
These results indicate that this kit can be used to determine relative mass values for naturally occurring human Angiopoietin-1. (novusbio.com)

In mouse kidney maturation, Ang-2 is expressed in arteries, with lower levels in tubules, whereas Tie-2 is expressed by endothelia. (nih.gov)
The angiopoietin (Ang) family of growth factors is known to mainly promote vessel maturation and remodeling ( 10 ). (spandidos-publications.com)

Several investigational drugs that target the angiopoietin axis are currently in clinical trials. (aacrjournals.org)
Circulating Ang-2 was measured in 162 patients with severe AAV (BVAS/WG≥3, with or without glomerulonephritis) in a clinical trial. (elsevier.com)
Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. (mysciencework.com)
Clinical trials of β 2 -agonists, statins, surfactants and keratinocyte growth factor (KGF) have been disappointing. (springer.com)

Summary Collectively, our findings suggest that in brain endothelial cells blocking PTPN-2 mediated tyrosine phosphorylation of Occludin is a novel mechanism to maintain BBB function, and may offer a key therapeutic strategy for neuro-inflammatory disorders associated with BBB disruption. (northwestern.edu)
Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6 dyn/cm 2 , 24 h), nuclear exclusion of Foxo-1 by phosphorylation increased. (elsevier.com)

Rabbit anti-Ang-2 was used at a 1:500 dilution to detect mouse Ang-2 in supernatants of mouse-angiopoietin-expressing endothelial cells. (antibodies-online.com)

However, expression levels of Tie-2 were greatest for BRMEC. (arvojournals.org)
Ang-2 expression in the ectopic and eutopic endometria serves an important role in the pathogenesis and development of endometriosis ( 11 ). (spandidos-publications.com)
This modification of Sp3 causes decreased binding of the repressor complex to a glucose-responsive GC box in the angiopoietin-2 promoter, resulting in increased Ang-2 expression. (elsevier.com)
Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. (wikigenes.org)

Anatomy12

Organisms5

Diseases7

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes15

Disciplines and Occupations1

Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (1/540)

Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. (2/540)

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. (3/540)

Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes. (4/540)

Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. (5/540)

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. (6/540)

Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity. (7/540)

Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval. (8/540)

Angiopoietin-2

Angiopoietin-1

Receptor, TIE-2

Angiopoietins

Receptor, TIE-1

Receptors, TIE

Angiogenesis Inducing Agents

Vascular Endothelial Growth Factor A

Neovascularization, Physiologic

Endothelial Cells

Neovascularization, Pathologic

Vascular Endothelial Growth Factors

Mycoplasma pulmonis

Angiogenic Proteins

Endothelial Growth Factors

Receptor Protein-Tyrosine Kinases

Lymphokines

Blood Vessels

Vascular Endothelial Growth Factor Receptor-2

Pericytes

Retinal Neovascularization

Membrane Glycoproteins

Capillaries

Endothelium, Vascular

Vascular Endothelial Growth Factor Receptor-1

Intercellular Signaling Peptides and Proteins

Retinal Vessels

Cells, Cultured

Angiogenesis Inhibitors

RNA, Messenger

Signal Transduction

Receptors, Vascular Endothelial Growth Factor

In Situ Hybridization

Retinal Perforations

Immunohistochemistry

Capillary Permeability

Reverse Transcriptase Polymerase Chain Reaction

Fovea Centralis

Proteins

Diabetic Retinopathy

Cell Proliferation

Up-Regulation

Receptors, Growth Factor

Umbilical Veins

Vitrectomy

Gene Expression Regulation

Mice, Inbred C57BL

Vitreous Body

Proto-Oncogene Proteins

Blotting, Western

Macular Edema

Enzyme-Linked Immunosorbent Assay

Neoplasm Proteins

Disease Models, Animal

Cell Movement

Ischemia

Time Factors

Apoptosis

Gene Expression

Mice, Transgenic

Fibroblast Growth Factor 2

Transfection

Phosphorylation

Biological Markers

Cell Survival

Gene Expression Profiling

Mice, Knockout

Dose-Response Relationship, Drug

Pregnancy

Rats, Sprague-Dawley

Cell Line, Tumor

Cell Line

Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (1/540)

Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. (2/540)

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. (3/540)

Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes. (4/540)

Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. (5/540)

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. (6/540)

Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity. (7/540)

Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval. (8/540)

$Gentaur Molecular :Reliatech \ Human Angiopoietin 1 Ang 1 Source HeLa cells \ 300-047$ Gentaur Molecular :Reliatech \ Human Angiopoietin 1 Ang 1 Source HeLa cells \ 300-047

$Gentaur Molecular :Reliatech \ Anti Mouse, mab Angiopoietin like protein 3 Source Rat \ 103-M307$ Gentaur Molecular :Reliatech \ Anti Mouse, mab Angiopoietin like protein 3 Source Rat \ 103-M307