Small breaks in the elastin-filled tissue of the retina.
An inherited disorder of connective tissue with extensive degeneration and calcification of ELASTIC TISSUE primarily in the skin, eye, and vasculature. At least two forms exist, autosomal recessive and autosomal dominant. This disorder is caused by mutations of one of the ATP-BINDING CASSETTE TRANSPORTERS. Patients are predisposed to MYOCARDIAL INFARCTION and GASTROINTESTINAL HEMORRHAGE.
Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
A pathological process consisting of the formation of new blood vessels in the CHOROID.
The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)

Angioid streaks. I. Ophthalmoscopic variations and diagnostic problems. (1/26)

Fifty-six patients with angioid streaks were evaluated ophthalmologically. Most had repeated fundus photography and fluorescein angiography during a follow-up period of 6 months to 7 years. The ophthalmoscopic variations and diagnostic difficulties which occurred were noted. In most instances, the angioid streaks were not initially recognized and the patient was referred with another diagnosis. In several cases, the peripapillary, macular, and peripheral changes seen with angioid streaks were found to simulate other better known fundus conditions, resulting in the erroneous diagnosis and improper treatment. In some cases, the angioid streaks were so subtle that they were overlooked and in others they were observed, but initially interpreted as something else. Because of the medical significance of angioid streaks, ophthalmologists should be aware of their variable features. These are discussed, with emphasis upon those subtleties which differentiate angioid streaks from other conditions which they may simulate. On the basis of these observations, an ophthalmoscopic differential diagnosis of angioid streaks is proposed.  (+info)

Angioid streaks and traumatic ruptures of Bruch's membrane. (2/26)

Minor blunt trauma may cause typical haemorrhages and probably enlargement of breaks or new breaks in patients affected with the Groenblad-Strandberg syndrome.  (+info)

Elastic tissue abnormalities resembling pseudoxanthoma elasticum in beta thalassemia and the sickling syndromes. (3/26)

The development of clinical and histopathologic manifestations of a diffuse elastic tissue defect, resembling inherited pseudoxanthoma elasticum (PXE), has been encountered with a notable frequency in patients with beta thalassemia, sickle cell disease, and sickle thalassemia. The PXE-like clinical syndrome, consisting of skin, ocular, and vascular manifestations, has a variable severity in these hemoglobinopathies and it is age-dependent, with a generally late onset, after the second decade of life. The defect is believed to be acquired rather than inherited and related to the consequences of the primary disease. The high prevalence of the findings implicates the elastic tissue injury as one of the main comorbid abnormalities encountered in beta thalassemia and the sickling syndromes. In these patients a number of complications, sometimes serious, has been recognized to be related to ocular and vascular elastic tissue defects. Because several organ systems are involved, each medical specialty should be aware of the phenomenon. This coexistence, on the other hand, introduces a novel pathogenetic aspect of PXE and an important research challenge.  (+info)

Angioid streaks and sickle haemoglobinopathies. (4/26)

Five patients had angioid streaks associated with sickle cell haemoglobinopathy. Other diseases associated with angioid streaks were ruled out, as was elastic tissue degenegation in sickle cell patients. After studying over 350 patients, we believe the incidence of angioid streaks in sickle cell disease to be between 1 and 2 per cent.  (+info)

Intravascular ultrasound findings of coronary wall morphology in a patient with pseudoxanthoma elasticum. (5/26)

Pseudoxanthoma elasticum (PXE) is an inherited disorder characterised by progressive calcification of the elastic fibres in the skin, eye, and cardiovascular system. Recently, mutations in the ATP binding cassette transporter gene (ABCC6) were identified as cause of this disease. Although patients with PXE often have coronary artery disease, little is known about the process and the mechanism of coronary artery disease in PXE. In this report, intravascular ultrasound (IVUS) imaging was performed in a female patient with PXE seven years after the onset of skin lesion to assess the coronary wall morphology in detail. IVUS showed a unique five layer appearance without acoustic shadowing along the vessel wall observed in the angiographically normal portion. These findings may reflect the earlier stage of coronary artery disease caused by PXE before calcification of the internal elastic laminae.  (+info)

Photodynamic therapy with verteporfin for choroidal neovascularization in patients with angioid streaks. (6/26)

PURPOSE: To evaluate the functional and anatomic outcomes of photodynamic therapy (PDT) for choroidal neovascularization (CNV) in patients with angioid streaks. METHODS: The authors retrospectively evaluated 6 consecutive patients (6 eyes) with CNV secondary to angioid streaks. All patients were treated with standard PDT with verteporfin protocol. Standardized protocol refraction, visual acuity testing, ophthalmologic examination, color photographs, fluorescein angiograms and indocyanin angiograms were used to evaluate the results of PDT with verteporfin. Main outcome measures were visual acuity and CNV size. RESULTS: Their mean age was 61.3+/-5.50 years (range, 53-68 years). Follow-up time ranged from 12 to 38 months with mean of 20.5+/-10.91 months. The mean visual acuity at baseline was 20/100 (range 20/25-20/500), and the mean visual acuity at the last examination was 20/320(range 20/125-counting finger). The mean greatest linear dimension (GLD) at baseline was 2400+/-766.81 micrometer, and the mean GLD at the last examination was 3483+/-444.59 micrometer. CONCLUSIONS: PDT for CNV associated with angioid streaks seemed to slow down but not prevent the progression of the disease and associated visual loss.  (+info)

Intravitreal bevacizumab (Avastin) in choroidal neovascular membrane in angioid streaks. (7/26)

Angioid streaks are crack-like dehiscences in the Bruch's membrane, which predispose to the development of a choroidal neovascular membrane (CNVM) that carries a poor visual outcome. We report successful treatment in a 25-year-old woman with bilateral angioid streaks and subfoveal CNVM in the left eye who received two doses of intravitreal bevacizumab (1.25 mg) injections six weeks apart, resulting in rapid regression of the CNVM.  (+info)

Non-vascular vision loss in pseudoxanthoma elasticum. (8/26)

Pseudoxanthoma elasticum patients with angioid streaks are well-known to have acute vision loss due to choroidal bleeding. However, chronic vision loss due to macular atrophy is less well characterized. We describe a patient with sub-acute vision loss in one eye due to loss of macular retinal pigment epithelium function. Autofluorescence and pattern electroretinogram were useful adjuncts to help diagnose the source of her vision loss.  (+info)

Angioid streaks can be detected during an eye exam using a specialized microscope called a fundus camera. If the streaks are caused by diabetic retinopathy or other underlying conditions, treatment may involve managing the underlying condition to prevent further damage to the blood vessels in the retina. In some cases, laser surgery may be recommended to seal off leaking blood vessels and prevent further bleeding.

In summary, Angioid streaks are a sign of damage to the blood vessels in the retina and can be a warning sign of more serious underlying conditions such as diabetic retinopathy or hypertensive retinopathy. It is important to seek medical attention if you notice any changes in your vision or see flashes of light, as these can be signs of a more serious condition.

The main symptoms of PXE include:

1. Skin changes: Pigmented spots or patches on the skin, particularly on the neck, face, and arms. These spots can become more prominent with age.
2. Eye problems: PXE can cause a range of eye problems, including cataracts, glaucoma, and retinal degeneration.
3. Cardiovascular disease: PXE is associated with an increased risk of cardiovascular disease, including high blood pressure, peripheral artery disease, and aneurysms.
4. Other symptoms: PXE can also cause a range of other symptoms, including fatigue, muscle weakness, and cognitive decline.

PXE is diagnosed through a combination of clinical examination, laboratory tests, and genetic analysis. There is no cure for PXE, but treatment can help manage the symptoms. Treatment options may include medications to control high blood pressure, glaucoma, and other eye problems, as well as physical therapy to maintain muscle strength and mobility.

The prognosis for PXE varies depending on the severity of the symptoms and the presence of any complications. With proper management, many people with PXE can lead active and fulfilling lives. However, the condition can be debilitating and can significantly impact quality of life if left untreated or inadequately managed.

Overall, pseudoxanthoma elasticum is a rare and complex disorder that requires careful management and monitoring to minimize its impact on daily life. With appropriate treatment and support, many people with PXE can lead fulfilling lives.

CNV develops when the underlying choroidal layers experience changes that lead to the growth of new blood vessels, which can leak fluid and cause damage to the retina. This can result in vision distortion, loss of central vision, and even blindness if left untreated.

The formation of CNV is a complex process that involves various cellular and molecular mechanisms. It is thought to be triggered by factors such as oxidative stress, inflammation, and the presence of certain growth factors and proteins.

There are several clinical signs and symptoms associated with CNV, including:

1. Distortion of vision, including metamorphopsia (distorted vision of geometric shapes)
2. Blind spots or scotomas
3. Decreased central vision
4. Difficulty reading or performing other daily tasks
5. Reduced color perception
6. Sensitivity to light and glare

The diagnosis of CNV is typically made based on a comprehensive eye exam, including a visual acuity test, dilated eye exam, and imaging tests such as fluorescein angiography or optical coherence tomography (OCT).

There are several treatment options for CNV, including:

1. Anti-vascular endothelial growth factor (VEGF) injections: These medications work by blocking the growth of new blood vessels and can help improve vision and reduce the risk of further damage.
2. Photodynamic therapy: This involves the use of a light-sensitive medication and low-intensity laser therapy to damage and shrink the abnormal blood vessels.
3. Focal photocoagulation: This involves the use of a high-intensity laser to destroy the abnormal blood vessels in the central retina.
4. Vitrectomy: In severe cases, a vitrectomy may be performed to remove the vitreous gel and blood vessels that are causing the CNV.

It is important to note that these treatments do not cure CNV, but they can help improve vision and slow the progression of the disease. Regular follow-up appointments with an eye care professional are necessary to monitor the condition and adjust treatment as needed.

"Angioid Streaks (Knapp Streaks)". StatPearls. StatPearls Publishing. "Angioid Streaks - EyeWiki". eyewiki.aao.org. "Retina". ... eMedicine article on Angioid streaks Photos of Angioid streaks John F., Salmon (2020). "Acquired macular disorders". Kanski's ... Angioid streaks, also called Knapp streaks or Knapp striae, are small breaks in Bruch's membrane, an elastic tissue containing ... Angioid streaks are often associated with pseudoxanthoma elasticum, but have been found to occur in conjunction with other ...
Angioid streaks cause calcification, thickening and breaks in Bruch's membrane. Bruch's membrane was named after the German ... "Angioid Streaks - EyeWiki". eyewiki.aao.org. Pictures at National Eye Institute (Webarchive template wayback links, Articles ...
Associated conditions such as angioid streaks and retinitis pigmentosa should be screened for. Both the severity of optic disc ... Certain conditions have been associated with disc drusen such as retinitis pigmentosa, angioid streaks, Usher syndrome, Noonan ...
Angioid streaks: Angioid streaks may be seen in up to 6% of cases. Proliferative sickle retinopathy is the most severe ocular ...
Angioid streaks: ICGA can be used for diagnosing angioid streaks and their associated ocular pathologies. Vogt-Koyanagi-Harada ...
Angioid streaks may develop, possibly as a result of calcification of collagen or other pathological deposition. Paget's ...
Angioid streaks themselves do not cause distortion of vision, even if they cross into the foveal area. This symptom is present ... The diagnostic criteria for PXE are the typical skin biopsy appearance and the presence of angioid streaks in the retina. ... Eventually the mineralization of the elastic fibers in the Bruch membrane create cracks called angioid streaks that radiate out ... angioid streaks > 1 DD or peau d'orange in an individual ...
"Knapp streaks"; also known as angioid streaks, which are tiny breaks in the elastin-filled tissue in the back of the eye. He ...
The inherited disorder pseudoxanthoma elasticum may lead to angioid streaks with calcification of Bruch's membrane, the elastic ...
... he was the first physician to describe angioid streaks, a disorder that affects Bruch's membrane, the innermost layer of the ...
... angioid streaks (H35.3) (H31.2) Hereditary choroidal dystrophy Choroideremia Dystrophy, choroidal (central areolar) ( ...
Other examples of peau d'orange occur in the eye due to breaks in Bruch's Membrane called angioid streaks, which are common in ...
... angioid streaks, epicanthal folds, strabismus, corneal scarring, brittle cornea syndrome, cataracts, carotid-cavernous sinus ...
... angioid streaks MeSH C11.768.257 - diabetic retinopathy MeSH C11.768.328 - epiretinal membrane MeSH C11.768.400 - retinal ...
Angioid Streaks 1 - OD 0 2 - OS 1 3 - OU 0 Blank 10126 466 Detachment 1 - OD 5 2 - OS 8 3 - OU 2 Blank 10112 467 Drusen 1 - OD ... 76 61 00 Angioid streaks 76 62 00 Degeneration, retina, peripheral NOS 76 63 00 Degeneration, retina, peripheral, cystic, ...
Differential diagnosis of angioid streaks includes hemoglobinopathies (sickle cell disease, Beta-thalassemia, spherocytosis), ... Dystrophic calcification of Bruchs membrane of the retina, revealed by angioid streaks at fundus examination, may trigger ... Fundus examination reveals characteristic retinopathy with angioid streaks, drusen or maculopathy. Genetic testing for ABCC6 ...
... and abnormalities called angioid streaks affecting tissue at the back of the eye, which can be detected during an eye ...
"ANGIOID STREAKS" N1OP0466 = "DETACHMENT" N1OP0467 = "DRUSEN" N1OP0468 = "INFLAMMATION-CHORIORETINITS" N1OP0469 = "ACTIVE" ...
Ocular features include angioid streaks, peau dorange fundus, and drusen. We report a novel ABCC6 mutation causing PXE in a ... Ocular imaging revealed angioid streaks emanating from the optic nerve as well as peripheral pigmentary changes and bone ... The patient presented both with peripheral pigmentary changes and angioid streaks. Further investigation into this novel ...
Angioid Streak. Streak, Angioid. Streaks, Angioid. Tree number(s):. C11.768.094. RDF Unique Identifier:. https://id.nlm.nih.gov ...
Choroidal Neovascularization Associated with Angioid Streaks in a Patient with Pseudoxanthoma Elasticum. Enver Mirza*1, Feyza ...
Angioid streaks of choroid 136350=Hereditary choroidal dystrophy or atrophy, unspecified 136351=Circumpapillary dystrophy ...
Angioid Streaks. Bluterkrankungen (siehe unter Systemerkrankungen). Hereditäre Degenerationen und Dystrophien, s.a. Kongenitale ...
Angioid Streaks. *Anterior Ischemic Optic Neuropathy (AION). *Choroidal Nevus & CHRPE. *Central Serous Retinopathy (CSR) ...
Choroidal neovascularization in a case of angioid streaks.. Nagpal, Manish; Bhardwaj, Sidharth. ...
Later in 1892, Knapp named them angioid streaks because of their resemblance to blood vessels. ... Doyne first described angioid streaks in a patient with retinal hemorrhages secondary to trauma. ... encoded search term (Angioid Streaks) and Angioid Streaks What to Read Next on Medscape ... Angioid Streaks Differential Diagnoses. Updated: Jul 23, 2021 * Author: Mohammad Abusamak, MD, FICO, FRCS(Glasg), MRCS(Edin); ...
Pseudoxanthoma elasticum and angioid streaks S Choudhary 1 , A Srivastava 1 , S Gupta 2 ... Angioid streaks and elastic pseudoxanthoma]. Chariba S, Daoudi R. Chariba S, et al. Pan Afr Med J. 2015 Mar 16;20:250. doi: ... Angioid streaks in pseudoxanthoma elasticum. Waqar M, Dhingra N. Waqar M, et al. Postgrad Med J. 2019 Apr;95(1122):220. doi: ... Angioid streaks. Clarkson JG, Altman RD. Clarkson JG, et al. Surv Ophthalmol. 1982 Mar-Apr;26(5):235-46. doi: 10.1016/0039-6257 ...
Intravitreal bevacizumab (Avastin) treatment of choroidal neovascularisation in patients with angioid streaks. Br J Ophthalmol ...
Angioid streaks ---Choroidal nevus within 2 DD of the center of the macula associated with depigmentation or overlying atypical ...
Angioid streaks of the fundus Arterial stenosis Excessive wrinkled skin Lack of skin elasticity Retinal hemorrhage Retinopathy ... Angioid Streaks of The Fundus. Synonym: Angioid Streaks. Synonym: Angioid Streaks of The Retina ...
Angioid streaks of the retina. Patients with angioid streaks of the retina should be followed by an ophthalmologist. ... Angioid streaks *. Patients should be referred to an ophthalmologist for evaluation, treatment, and monitoring of angioid ... Angioid streaks of the retina were reported in four individuals with HFTC [McPhaul & Engel 1961, Yancovitch et al 2011]. One ... Heterotopic calcification, hyperphosphatemia and angioid streaks of the retina. Am J Med. 1961;31:488-92. [PubMed: 13774168] ...
8. Peau dorange and angioid streaks: manifestations of Bruch membrane pathology.. Spaide RF. Retina; 2015 Mar; 35(3):392-7. ...
Angioid Streaks Preferred Concept UI. M0001189. Scope Note. Small breaks in the elastin-filled tissue of the retina.. Terms. ... Angioid Streaks Preferred Term Term UI T002354. Date01/01/1999. LexicalTag NON. ThesaurusID ... Angioid Streaks. Tree Number(s). C11.768.094. Unique ID. D000793. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D000793 ...
Title: Retinal Angioid Streaks Painting , Artist: Bartner, Howard , Requesting Physician: Dr. Einaugher , Institute: NINDB,, ... Title: Retinal Angioid Streaks Painting , Artist: Bartner, Howard , Requesting Physician: Dr. Einaugher , Institute: NINDB,, ... Title: Retinal Angioid Streaks Painting , Artist: Bartner, Howard , Requesting Physician: Dr. Einaugher , Institute: NINDB,, ... Title: Retinal Angioid Streaks Painting , Artist: Bartner, Howard , Requesting Physician: Dr. Einaugher , Institute: NINDB,, ...
Angioid Streaks Preferred Concept UI. M0001189. Scope Note. Small breaks in the elastin-filled tissue of the retina.. Terms. ... Angioid Streaks Preferred Term Term UI T002354. Date01/01/1999. LexicalTag NON. ThesaurusID ... Angioid Streaks. Tree Number(s). C11.768.094. Unique ID. D000793. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D000793 ...
Angioid streaks of choroid (disorder) {86103006 , SNOMED-CT } Parent/Child (Relationship Type) Angioid streaks of choroid of ... Angioid streaks of choroid (disorder). Code System Preferred Concept Name. Angioid streaks of choroid (disorder). ...
Worldwide source of medical classification resources ...
... angiographically angiographies angiographs angiography angiohemophilia angiohypotensin angioid angioid streak angioid streaks ... Bromelia hieronymi Bromelia karatas Bromelia pinguin Bromelia plumieri bromelin bromelins bromerguride bromes brome streak ...
86103006 Angioid streaks of choroid (disorder) 86219005 Uveitis-rheumatoid arthritis syndrome (disorder) 86216003 Mastitis, ...
Ophthalmologist for optic atrophy or angioid retinal streak * Oncologist for neoplastic complications ...
Examples are angioid streaks of the ophthalmologist and pseudoxanthoma elasticum of the dermatologist. Wer- mer described the ...
Angioid streaks of choroid 136350=Hereditary choroidal dystrophy or atrophy, unspecified 136351=Circumpapillary dystrophy ...
The dream that merges with hope, for those suffering from diseases such as Angioid Streaks (a sort of "fracture" of the choroid ...
T003768Atheroscleroses T003768Atherosclerosis T003769Arterial Fatty Streak T003769Arterial Fatty Streaks T003769Fatty Streak, ... Angioid T002354Streaks, Angioid T002355Angiokeratoma T002355Angiokeratomas T002356Angiokeratoma Corporis Diffusum ... Gut T017401Primitive Guts T017402Archenteron T017402Archenterons T017403Primitive Streak T017403Primitive Streaks T017403Streak ... T002352Angiography T002353Arteriographies T002353Arteriography T002354Angioid Streak T002354Angioid Streaks T002354Streak, ...
Angioid Streaks Angiokeratoma Angiolipoma Angiolymphoid Hyperplasia with Eosinophilia Angiomatosis Angiomatosis, Bacillary ...
  • Less frequently reported findings include testicular microlithiasis and angioid streaks of the retina. (nih.gov)
  • Kubota M, Hayashi T, Arai K, Tsuneoka H. Choroidal neovascularization after blunt ocular trauma in angioid streaks. (medscape.com)
  • Ozdek S, Bozan E, Gürelik G, Hasanreisoglu B. Transpupillary thermotherapy for the treatment of choroidal neovascularization secondary to angioid streaks. (medscape.com)
  • Photodynamic therapy with verteporfin for choroidal neovascularization in patients with angioid streaks. (medscape.com)
  • Esen E, Sizmaz S, Demircan N. Intravitreal aflibercept for management of subfoveal choroidal neovascularization secondary to angioid streaks. (medscape.com)
  • Vaz-Pereira S, Collaço L, De Salvo G, van Zeller P. Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. (medscape.com)
  • Sawa M, Gomi F, Tsujikawa M, Sakaguchi H, Tano Y. Long-term results of intravitreal bevacizumab injection for choroidal neovascularization secondary to angioid streaks. (medscape.com)
  • Neri P, Salvolini S, Mariotti C, Mercanti L, Celani S, Giovannini A. Long-term control of choroidal neovascularisation secondary to angioid streaks treated with intravitreal bevacizumab (Avastin). (medscape.com)
  • Peripheral Linear Streaks in Pseudoxanthoma Elasticum. (nih.gov)
  • Angioid streaks: Pseudoxanthoma elasticum, der Zusammenhang zwischen diesen gleichzeitig auftretenden Augen- und Hautveränderungen. (nih.gov)
  • Examples are angioid streaks of the ophthalmologist and pseudoxanthoma elasticum of the dermatologist. (nih.gov)
  • and abnormalities called angioid streaks affecting tissue at the back of the eye, which can be detected during an eye examination. (medlineplus.gov)
  • Angioid Streaks: A clinical and histopathologic study. (medscape.com)
  • A Case of Papillophlebitis Caused by the Contraceptive Implant in a Healthy Young Woman with Angioid Streaks. (medscape.com)