Angioid Streaks: Small breaks in the elastin-filled tissue of the retina.Pseudoxanthoma Elasticum: An inherited disorder of connective tissue with extensive degeneration and calcification of ELASTIC TISSUE primarily in the skin, eye, and vasculature. At least two forms exist, autosomal recessive and autosomal dominant. This disorder is caused by mutations of one of the ATP-BINDING CASSETTE TRANSPORTERS. Patients are predisposed to MYOCARDIAL INFARCTION and GASTROINTESTINAL HEMORRHAGE.Fluorescein Angiography: Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.Choroidal Neovascularization: A pathological process consisting of the formation of new blood vessels in the CHOROID.Fundus Oculi: The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)Elastic Tissue: Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.Multidrug Resistance-Associated Proteins: A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.Gastrointestinal Diseases: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Intravitreal Injections: The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.Visual Acuity: Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.KentuckyTrephining: The removal of a circular disk of the cranium.Photochemotherapy: Therapy using oral or topical photosensitizing agents with subsequent exposure to light.Angiogenesis Inhibitors: Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.Wet Macular Degeneration: A form of RETINAL DEGENERATION in which abnormal CHOROIDAL NEOVASCULARIZATION occurs under the RETINA and MACULA LUTEA, causing bleeding and leaking of fluid. This leads to bulging and or lifting of the macula and the distortion or destruction of central vision.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Retinal Hemorrhage: Bleeding from the vessels of the retina.Risk Management: The process of minimizing risk to an organization by developing systems to identify and analyze potential hazards to prevent accidents, injuries, and other adverse occurrences, and by attempting to handle events and incidents which do occur in such a manner that their effect and cost are minimized. Effective risk management has its greatest benefits in application to insurance in order to avert or minimize financial liability. (From Slee & Slee: Health care terms, 2d ed)Product Surveillance, Postmarketing: Surveillance of drugs, devices, appliances, etc., for efficacy or adverse effects, after they have been released for general sale.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Databases, Bibliographic: Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Fat Substitutes: Compounds used in food or in food preparation to replace dietary fats. They may be carbohydrate-, protein-, or fat-based. Fat substitutes are usually lower in calories but provide the same texture as fats.Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.Acneiform Eruptions: Visible efflorescent lesions of the skin caused by acne or resembling acne. (Dorland, 28th ed, p18, 575)Coronary Vasospasm: Spasm of the large- or medium-sized coronary arteries.Tinea Pedis: Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.Osteitis Deformans: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.Paget's Disease, Mammary: An intraductal carcinoma of the breast extending to involve the nipple and areola, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (Paget's cells). (Dorland, 27th ed)Paget Disease, Extramammary: A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Osteitis: Inflammation of the bone.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Apocynaceae: The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters. Asclepiadacea (formerly the milkweed family) has been included since 1999 and before 1810.BrazilNigeria: A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.Feeding Methods: Methods of giving food to humans or animals.Trypanosoma vivax: An active blood parasite that is present in practically all domestic animals in Africa, the West Indies, and parts of Central and South America. In Africa, the insect vector is the tsetse fly. In other countries, infection is by mechanical means indicating that the parasites have been introduced to these countries and have been able to maintain themselves in spite of the lack of a suitable intermediate host. It is a cause of nagana, the severity of which depends on the species affected.CinnamatesCyclopropanesCopyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Software: Sequential operating programs and data which instruct the functioning of a digital computer.Retinal Drusen: Colloid or hyaline bodies lying beneath the retinal pigment epithelium. They may occur either secondary to changes in the choroid that affect the pigment epithelium or as an autosomal dominant disorder of the retinal pigment epithelium.Retinal Pigment Epithelium: The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.Ophthalmology: A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.Optic Nerve: The 2nd cranial nerve which conveys visual information from the RETINA to the brain. The nerve carries the axons of the RETINAL GANGLION CELLS which sort at the OPTIC CHIASM and continue via the OPTIC TRACTS to the brain. The largest projection is to the lateral geniculate nuclei; other targets include the SUPERIOR COLLICULI and the SUPRACHIASMATIC NUCLEI. Though known as the second cranial nerve, it is considered part of the CENTRAL NERVOUS SYSTEM.Bruch Membrane: The inner layer of CHOROID, also called the lamina basalis choroideae, located adjacent to the RETINAL PIGMENT EPITHELIUM; (RPE) of the EYE. It is a membrane composed of the basement membranes of the choriocapillaris ENDOTHELIUM and that of the RPE. The membrane stops at the OPTIC NERVE, as does the RPE.

Angioid streaks. I. Ophthalmoscopic variations and diagnostic problems. (1/26)

Fifty-six patients with angioid streaks were evaluated ophthalmologically. Most had repeated fundus photography and fluorescein angiography during a follow-up period of 6 months to 7 years. The ophthalmoscopic variations and diagnostic difficulties which occurred were noted. In most instances, the angioid streaks were not initially recognized and the patient was referred with another diagnosis. In several cases, the peripapillary, macular, and peripheral changes seen with angioid streaks were found to simulate other better known fundus conditions, resulting in the erroneous diagnosis and improper treatment. In some cases, the angioid streaks were so subtle that they were overlooked and in others they were observed, but initially interpreted as something else. Because of the medical significance of angioid streaks, ophthalmologists should be aware of their variable features. These are discussed, with emphasis upon those subtleties which differentiate angioid streaks from other conditions which they may simulate. On the basis of these observations, an ophthalmoscopic differential diagnosis of angioid streaks is proposed.  (+info)

Angioid streaks and traumatic ruptures of Bruch's membrane. (2/26)

Minor blunt trauma may cause typical haemorrhages and probably enlargement of breaks or new breaks in patients affected with the Groenblad-Strandberg syndrome.  (+info)

Elastic tissue abnormalities resembling pseudoxanthoma elasticum in beta thalassemia and the sickling syndromes. (3/26)

The development of clinical and histopathologic manifestations of a diffuse elastic tissue defect, resembling inherited pseudoxanthoma elasticum (PXE), has been encountered with a notable frequency in patients with beta thalassemia, sickle cell disease, and sickle thalassemia. The PXE-like clinical syndrome, consisting of skin, ocular, and vascular manifestations, has a variable severity in these hemoglobinopathies and it is age-dependent, with a generally late onset, after the second decade of life. The defect is believed to be acquired rather than inherited and related to the consequences of the primary disease. The high prevalence of the findings implicates the elastic tissue injury as one of the main comorbid abnormalities encountered in beta thalassemia and the sickling syndromes. In these patients a number of complications, sometimes serious, has been recognized to be related to ocular and vascular elastic tissue defects. Because several organ systems are involved, each medical specialty should be aware of the phenomenon. This coexistence, on the other hand, introduces a novel pathogenetic aspect of PXE and an important research challenge.  (+info)

Angioid streaks and sickle haemoglobinopathies. (4/26)

Five patients had angioid streaks associated with sickle cell haemoglobinopathy. Other diseases associated with angioid streaks were ruled out, as was elastic tissue degenegation in sickle cell patients. After studying over 350 patients, we believe the incidence of angioid streaks in sickle cell disease to be between 1 and 2 per cent.  (+info)

Intravascular ultrasound findings of coronary wall morphology in a patient with pseudoxanthoma elasticum. (5/26)

Pseudoxanthoma elasticum (PXE) is an inherited disorder characterised by progressive calcification of the elastic fibres in the skin, eye, and cardiovascular system. Recently, mutations in the ATP binding cassette transporter gene (ABCC6) were identified as cause of this disease. Although patients with PXE often have coronary artery disease, little is known about the process and the mechanism of coronary artery disease in PXE. In this report, intravascular ultrasound (IVUS) imaging was performed in a female patient with PXE seven years after the onset of skin lesion to assess the coronary wall morphology in detail. IVUS showed a unique five layer appearance without acoustic shadowing along the vessel wall observed in the angiographically normal portion. These findings may reflect the earlier stage of coronary artery disease caused by PXE before calcification of the internal elastic laminae.  (+info)

Photodynamic therapy with verteporfin for choroidal neovascularization in patients with angioid streaks. (6/26)

PURPOSE: To evaluate the functional and anatomic outcomes of photodynamic therapy (PDT) for choroidal neovascularization (CNV) in patients with angioid streaks. METHODS: The authors retrospectively evaluated 6 consecutive patients (6 eyes) with CNV secondary to angioid streaks. All patients were treated with standard PDT with verteporfin protocol. Standardized protocol refraction, visual acuity testing, ophthalmologic examination, color photographs, fluorescein angiograms and indocyanin angiograms were used to evaluate the results of PDT with verteporfin. Main outcome measures were visual acuity and CNV size. RESULTS: Their mean age was 61.3+/-5.50 years (range, 53-68 years). Follow-up time ranged from 12 to 38 months with mean of 20.5+/-10.91 months. The mean visual acuity at baseline was 20/100 (range 20/25-20/500), and the mean visual acuity at the last examination was 20/320(range 20/125-counting finger). The mean greatest linear dimension (GLD) at baseline was 2400+/-766.81 micrometer, and the mean GLD at the last examination was 3483+/-444.59 micrometer. CONCLUSIONS: PDT for CNV associated with angioid streaks seemed to slow down but not prevent the progression of the disease and associated visual loss.  (+info)

Intravitreal bevacizumab (Avastin) in choroidal neovascular membrane in angioid streaks. (7/26)

Angioid streaks are crack-like dehiscences in the Bruch's membrane, which predispose to the development of a choroidal neovascular membrane (CNVM) that carries a poor visual outcome. We report successful treatment in a 25-year-old woman with bilateral angioid streaks and subfoveal CNVM in the left eye who received two doses of intravitreal bevacizumab (1.25 mg) injections six weeks apart, resulting in rapid regression of the CNVM.  (+info)

Non-vascular vision loss in pseudoxanthoma elasticum. (8/26)

Pseudoxanthoma elasticum patients with angioid streaks are well-known to have acute vision loss due to choroidal bleeding. However, chronic vision loss due to macular atrophy is less well characterized. We describe a patient with sub-acute vision loss in one eye due to loss of macular retinal pigment epithelium function. Autofluorescence and pattern electroretinogram were useful adjuncts to help diagnose the source of her vision loss.  (+info)

Looking for online definition of angioid streak in the Medical Dictionary? angioid streak explanation free. What is angioid streak? Meaning of angioid streak medical term. What does angioid streak mean?
Aim: To evaluate the efficacy of intravitreal bevacizumab (IB) in the long-term control of subfoveal choroidal neovascularization (CNV) associated with angioid streaks (AS).. Methods: Patients with unilateral active CNV associated with AS were enrolled. Exclusion criteria were previous treatment for CNV and co-morbidity. Postoperative visual acuity was defined as a gain or loss of 2 or more lines of best-corrected visual acuity (BCVA).. Post-treatment CNV size was dichotomized into "increased", if the CNV area had grown by ≥200 μm2, and "stable/reduced" if it had decreased by ≥200 μm2 or had not changed by more than 200 μm2. Patients were retreated if no further improvement or worsening was noted.. Results: Patients were 5 males and 6 females aged 33 to 58 years (mean 46.8±9.2 SD), who received a mean number of 3.5 IB treatments (±1.3; min: 2, max: 6). The mean retreatment interval was 3 months (±1.5; min: 1, max: 6). Mean follow-up duration was 23.8±2.9 months. At 20 months all ...
Angioid streaks result from an abnormal brittleness to the eye wall beneath the macula. Bennett & Blooms eye doctors can diagnose and treat this disease.
Pseudoxanthoma elasticum (PXE) is a hereditary disorder that affects primarily the elastic tissues of skin, eyes and blood vessels. Its estimated prevalence is thought to be 1:25,000 - 100,000. PXE patients also carry an increased risk for cardiovascular and gastrointestinal diseases. Early diagnosis can play a crucial role in preventing early loss of vision and systemic complications in these patients however despite having characteristic clinical features; it is still to a large extent being under-diagnosed. Here we present two cases of PXE with reduced vision.
Case 1: A 49 year-old woman with history of Hepatitis C and chronic mild leucopenia presents with vision loss of the right eye. Distance-corrected visual acuity (DCVA) of the right eye was hand movement and of the left eye was 10/10. Yellow papules and "plucked chicken" skin lesions compatible with pseudoxanthoma elasticum were found in the cervical skin. Typical lesions of angioid streaks were visible in both eyes, as well as subfoveal CNV associated with rupture of the retinal pigmentary epithelium (RPE), an area of subretinal haemorrhage and macular subretinal fibrosis. A protocol of three ranibizumab intravitreal injections (IVI) was proposed despite the reserved prognosis. Case 2: 48 year-old man presents with loss of vision of the left eye. DCVA in OD was 10/10 and 4/10 in the OS at presentation. A subfoveal lesion compatible with an acquired vitelliform lesion with associated rupture of the RPE and subretinal fluid was found on the left eye. Careful examination revealed angioid streaks in ...
Posterior Segment: There are numerous angioid streaks which appear as tortuous, dark brown cracks at the level of Bruchs membrane and radiate peripherally from the optic nerve. The midperipheral fundus has a peau dorange appearance. The left fundus demonstrates angioid streaks as well as optic nerve ...
The recent development of photodynamic therapy (PDT) for the treatment of subfoveal choroidal neovascularisation (CNV) has provoked considerable interest amongst UK ophthalmologists, patients, hospital managers, public health physicians and the media. The recent publication of the Treatment of Age-related Macular Degeneration (TAP) report1 and the further data expected soon from this and other randomised clinical trials is likely to have a major impact on service provision in the UK. The vast majority of cases of subfoveal CNV are caused by age-related macular degeneration (AMD) but other causes include pathological myopia, angioid streaks and punctate inner choroidopathy, especially in younger patients. Until very recently confluent argon laser photocoagulation has been the only treatment modality of proven clinical efficacy but after initial enthusiasm its role has become restricted to the treatment of eyes with extrafoveal CNV. In addition to PDT other therapeutic options for subfoveal CNV ...
Anterior Chamber Hyphema Peripheral Anterior Synechia Postoperative Flat Anterior Chamber Toxic Anterior Segment Syndrome koroid Angioid Streaks Choroidal Detachment Choroidal Melanoma Choroidal Neovascularization Choroidal Rupture Multifocal Choroidopathy Syndromes Konjuntiva Conjunctivitis Alergika Conjuntivitis Bakteri Bacterial Conjunctivitis Empiric Therapy Bacterial Conjunctivitis Organism-Specific Therapy Conjunctival Melanoma Conjunctival Papilloma Epidemic Keratoconjunctivitis Filtering Bleb Complications Giant Papillary Conjunctivitis Neonatal Conjunctivitis…
TY - BOOK. T1 - Anti-VEGF. AU - Bandello, Francesco. AU - Parodi, M. Battaglia. AU - Augustin, A. J.. AU - Iacono, P.. AU - Schlingemann, R. O.. AU - Schmidt-Erfurth, U.. AU - Verbraak, F. D.. PY - 2010/8/13. Y1 - 2010/8/13. N2 - The development of therapy with anti-angiogenics or vascular endothelial growth factor inhibitors (anti-VEGF) has marked the beginning of a new era in neovascularization and macular edema treatment. Its main goals are the inhibition of growth and development of new vessels along with the reduction of vascular permeability. The advantages over conventional laser photocoagulation are evident as laser treatment always leaves scars and causes a retinal sensitivity deterioration.Starting with an outline of treatment principles, this volume covers all aspects of anti-VEGF therapy for ophthalmological disorders. In particular, specific chapters are dedicated to age-related macular degeneration, degenerative myopia, angioid streaks, inflammatory diseases, hereditary ...
Skin lesions appear during the second decade of life, with a progressive increase in number and severity during adolescence. The disease is clinically heterogeneous, being limited to only one organ in some patients but affecting all three organs in others. The skin lesions consist of yellow papules that may merge to form plaques. They appear mainly in the flexural areas of the neck and elbows, popliteal spaces and umbilical region, and are accompanied by loosening of the skin around the inguinal folds and armpits. Ophthalmological findings include retinal pigment epithelium anomalies, drusen, angioid streaks (fissuring of the Bruch membrane of the retina), and neovascularization and bleeding leading to retinal hemorrhage and, in many patients, loss of visual acuity. Involvement of the macula may lead to patients being declared as legally blind. Cardiovascular manifestations lead to intermittent claudication of the lower and/or upper limbs due to arteriosclerosis of medium-sized arteries with ...
The Vascular Birthmarks Foundation provides support and resources for children and adults born with hemangiomas, port wine stains, and other vascular birthmarks.
Pseudoxanthoma elasticum is a hereditary connective tissue disease related to a mutation in the ABCC6 gene located on chromosome 16p13.1, that encodes the multidrug resistance protein 6 (MRP6), which is one of the family of adenosine triphosphate-dependent membrane transport proteins, which are mostly expressed in the liver and kidneys. Two types of inheritance have been described: autosomal recessive in 90% of the cases and autosomal dominant, much rarer. Mutation in the ABCC6 gene provokes an absence of MRP6, which leads to an accumulation of substances with a high affinity for elastic tissues, resulting in the distortion of calcium deposits and fragmentation of elastic fibers.. Cutaneous manifestations include asymptomatic yellowish papules distributed symmetrically from the start of the neck that can extend to the flexure area. Although not pathognomonic, a characteristic ocular finding is the presence of angioid streaks that represent calcium deposits on the Bruch membrane. They can cause ...
TY - JOUR. T1 - Intra-operative radiotherapy management for breast cancer treatment in patients with pseudoxanthoma elasticum. T2 - A case report. AU - Salerno, Carmela. AU - Vento, Anna Rita. AU - Giacchino, Maria. AU - Lissidini, Germana. AU - Galimberti, Viviana. AU - Corso, Giovanni. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Pseudoxanthoma elasticum is a systemic metabolic disease presenting calcifications and progressive fragmentation of elastic fibers. Actually, no targeted therapies are available for the treatment; only prevention of complications is possible. Classically, pseudoxanthoma elasticum is a "benign" disease, without cancer association. Herein, we reported a singular association of pseudoxanthoma elasticum with breast carcinoma, describing the clinical management, in particular intra-operative treatment, focusing on intra-operative radiotherapy since no specific guidelines are available in literature.. AB - Pseudoxanthoma elasticum is a systemic metabolic disease presenting ...
Pseudoxanthoma Elasticum: A Review of Neurological Complications A l e e m Iqbal, MD, Milton Alter, M D , P h D , a n d S e u n g h o H. Lee, MD ~ ~ A case of pseudoxanthoma elasticum w i t h multisystem involvement is described. Neurological complications, as reported i n t h e literature, are reviewed. T h e s e include cerebrovascular insufficiency, multiple lacunar infarcts, aneurysms, subarachnoid and intracerebral hemorrhages, progressive intellectual deterioration, and psychic and mental disturbance which may be due to cortical atrophy. Seizures occur m o r e frequently than in the general population. Hypertension and alteration of cerebral vessels are the two basic pathophysiological mechanisms responsible for t h e neurological complications of this disease. Iqbal A, Alter M, Lee SH: Pseudoxanthoma elasticum: a review of neurological complications. Ann Neurol 4: 18-20, I978 P s e u d o x a n t h o m a elasticum (PXE) is a rare hereditary disorder with peculiar loosening of the skin. ...
Pseudoxanthoma elasticum is a disease whom frequency is estimated about 1/50000 to 1/100 000. There is a female preponderance with a sex-ratio of 2:1. PXE is transmitted according either to an autosomal dominant mode or to an autosomal recessive one. Mutations in the ABCC6 gene on chromosome 16p13.1 have recently been identified causing PXE. The elastic fibers slowly become mineralized mainly in the skin, the eyes, and the cardiovascular system. PXE is a multisystem disease that includes a spectrum of clinical manifestations affecting the skin, the eye or the cardiovascular system as well as other tissues. It can be responsible for severe and life threatening complications. Skin changes are usually the first manifestations and begin in early childhood. The vital prognosis of PXE depends on the severity of the cardiovascular lesions that could be responsible for sudden death in children and young adults.. Ocular manifestations are quite constant and include chorioretinal scarring, pigmentary ...
The natural history of subfoveal CNV secondary to Pattern Dystrophy is little understood, but it seems that visual function may be preserved only in the short-term follow-up, with progressive deterioration thereafter.. Photodynamic therapy with verteporfin is the most studied therapeuthic option for this kindf of lesion, but unfortunately, this approach does not appear to guarantee long-term vision stabilization, and alternative therapies should be investigated. ...
I dont often create abstract - but every once in a while it just seems to come out. This is my first attempt at using Oil Pastels. As I began, I knew I wanted to paint a cross - as I listened to a new worship CD a dear friend has sent me. But what exactly it would look like I didnt know.. Its titled "Strength". Though the cross at first appears to be falling over, you can see its solidness in the shadow. And the clouds over head, though darkening the sky, are highlighted with bright gold and sunlit streaks are allowed through. The golden streaks appear as rain - and yet are lit up like sunshine.. Though life is difficult and we may face unexpected trials, the power of God is strong and holds us secure. This irony - things look bad, but God has a good plan - is what this piece of art represents.. I continue to hold onto this hope. Here are the words of a song on my new CD that have really encouraged me this week... ...
Cited for: VARIANTS PXE 60-ARG--TYR-62 DEL; GLU-129; ARG-317; ARG-355; ARG-364; ASP-370; GLY-391; GLY-398; HIS-495; GLN-518; SER-551; VAL-594; PRO-677; TRP-760; GLN-765; GLN-807; TRP-807; GLU-1056; PHE-1036 DEL; PHE-1048 DEL; CYS-1114; LEU-1121; GLN-1138; TRP-1138; GLN-1164; CYS-1221; TRP-1235; ARG-1302; PRO-1303; GLN-1314; CYS-1339; LEU-1339 AND TRP-1357; VARIANTS THR-78; LYS-125; VAL-158; GLY-265; GLU-281; VAL-319; ILE-514; ALA-614; GLN-632; LYS-724; VAL-742; ILE-946; TRP-1064 AND GLN-1268; Spectrum of genetic variation at the ABCC6 locus in South Africans: Pseudoxanthoma elasticum patients and healthy individuals. ...
This year The Undertaker helps to keep The Streak 22-0 by defeating Brock Lesnar at WrestleMania XXX. We ranked his previous 21 matches using science.
I suppose Ive always had a creative streak in me. How else can I explain my unique style of specific organization, creative piles...
One embodiment provides a gaming system providing a multiple streak game associated with a base or primary wagering game. The multiple streak game includes a multiple streak having a multiple streak continuation condition and a single streak having a single streak continuation condition. The multiple streak is initially the active streak. If an outcome a play of the base or primary wagering game satisfies the multiple streak continuation condition, the multiple streak remains the active streak and the player may win an award. If the outcome does not satisfy the multiple streak continuation condition but satisfies the single streak continuation condition, the multiple streak ends, the at least one single streak is set as the active streak, and the player may win an award. If the outcome does not satisfy either the multiple streak continuation condition or the at least one single streak continuation condition, the multiple streak game ends.
A patient first presents to a physician with perfectly symmetric PXE skin lesions on the outer neck. These lesions are without symptoms but are of cosmetic concern. The manifestation of PXE on the skin is very distinctive. Small, yellow papules 1-5mm in diameter form in a linear pattern. The skin takes on a "plucked chicken" appearance. As the disease progresses other symptoms may occur like gastrointestinal bleeding, high blood pressure, chest pain, and blood in the urine.. The cause of PXE is the result of a mutation in a protein that is most abundant in the kidney and liver cells. It is not understood why this would lead to abnormalities in other organs.. Diagnosis is made on clinical findings and several lab tests. A physician may order a simple blood test, a urinalysis, and stool screen. A biopsy of the lesion in question may also be ordered.. Many of the changes that occur with PXE are irreversible but preventive measures may be taken to minimize the disease course. The sagging folds of ...
When we tried to ascertain the presence of claudication, the patient reported burning pain in both calves during ongoing and strenuous physical exercise, such as rapid walking for more than 1000 meters, with immediate relief at rest. He first noticed these symptoms when he was about 16 years old, and since then the symptoms have remained constant. He denied the presence of chest pain at rest or on exertion and reported no abdominal symptoms. He started to smoke few cigarettes a day 4 years before presentation. He denied the presence of arterial hypertension, hyperlipidemia, and diabetes. Because of acne-like skin lesion on the neck, a skin biopsy had been performed 14 years earlier. His parents, 4 siblings, wife, and 2 children (2 and 4 years of age) were to his knowledge devoid of any major disease. Physical examination revealed nonpalpable popliteal, posterior tibial, and dorsalis pedis pulses on both sides. Radial and femoral pulses were palpable. No trophic skin changes of the lower limbs ...
Older people have loss of elastic tissue function, slow healing & reaction time, and chronic degeneration. How can doctors accommodate?
GRT Grasser Racing Teams #63 Lamborghini Huracan GT3 extended its 2017 Blancpain GT Series winning streak to four with a hard-fought victory at Silverstone
TY - JOUR. T1 - Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). AU - Iliás, Attila. AU - Urbán, Zsolt. AU - Seidl, Thomas L.. AU - Saux, Olivier Le. AU - Sinkó, Emese. AU - Boyd, Charles D.. AU - Sarkadi, B.. AU - Váradi, A.. PY - 2002/5/10. Y1 - 2002/5/10. N2 - Mutations in the ABCC6 (MRP6) gene cause pseudoxanthoma elasticum (PXE), a rare heritable disorder resulting in the calcification of elastic fibers. In the present study a cDNA encoding a full-length normal variant of ABCC6 was amplified from a human kidney cDNA library, and the protein was expressed in Sf9 insect cells. In isolated membranes ATP binding as well as ATP-dependent active transport by ABCC6 was demonstrated. We found that glutathione conjugates, including leukotriene C4 and N-ethylmaleimide S-glutathione (NEM-GS), were actively transported by human ABCC6. Organic anions (probenecid, benzbromarone, indomethacin), known to interfere with glutathione conjugate ...
Diseases such as pseudoxanthoma elasticum are hallmarked by calcification of soft tissues. In order to prevent and remove these unwanted calcifications, scientists are searching for the essential ingredients that cause the calcifications to occur. In this webinar we discuss the role of injury to tissues in the formation of such calcifications. Emphasis will be on the role of muscle injury in the formation of a disease process callled heterotopic ossification.
遺傳性皮膚疾病包括非常多影響皮膚不同程度的疾病1,某些情形只有輕微的影響皮膚、毛髮或指甲,對病患造成外觀上的困擾;但有時是嚴重多重器官的疾病,皮膚的表現只是其中一部分。例如先天性表皮鬆解性水皰症(Hereditary epidermolysis bullosa),會造成患者相當程度的併發症及死亡率2;而彈性纖維假黃瘤(pseudoxanthoma elasticum, PXE)的皮膚表現只是反映出嚴重的全身疾病,如視力 ..................More ...
This guy is my hero. He has the longest current running streak in America. As of February 25, 2016, the United States Running Streak Association reports the length of Sutherlands running streak as 17077 days (46.75 years). In addition to his amazing running streak, Jon has had a pretty colorful life. According to this article on ESPN, after running in college (at which time he began his running streak), Sutherland has worked in the rock and roll music industry, hes been a writer, and hes been a high school track coach. He has kept his running streak going through hectic schedules, broke bones, and torn muscles. Throughout all these 17077 days, Jon has run at least a mile a day, every day.. One reason I love to read about Jon Sutherland is that the success of his running streak defies all the conventional, overly cautious running wisdom. Unlike a great number of American runners, Sutherland runs without fear. Runners are told by doctors, physical therapists, and all manner of medical and ...
Randy Winn didnt have the blues over losing his 20-game hitting streak Tuesday night, even though it was the eighth longest since the Giants moved to San Francisco in 1958 and the longest by a switch hitter over that four-decade span. Winn said he was lucky to get as far as he did. On May 11, he didnt start because of a sore back but entered as a defensive replacement and reached on a bunt single to push his streak to 12 games.. He chopped an infield single against Roy Oswalt in Houston on May 17 to make it 16 consecutive games.. The streak didnt survive a second encounter with Oswalt, though. Winn grounded out three times, struck out in the seventh and was stranded in the on-deck circle in the eighth.. "He pitched me pretty tough," Winn said. "The last at-bat, I got a couple pitches to hit and I fouled them off. Before that, he didnt give me a whole lot.". Winn batted .388 during his streak, which was the longest by a Giant since Robby Thompson had a 21-game streak in 1993. Previously, the ...
Sudden growth on streak plates - posted in Microbiology: Hi, Im currently trying to isolate bacteria in pure culture from sponge samples. I started by plating a small amount of homogenised sponge sample on an agar plate and incubating it at room temperature as I was instructed, no problems. Then I picked individual colonies from these plates and streaked each one onto a fresh agar plate using the 13 streak method, again, no problems. I will have normal growth (text-book streak plate colon...
... ,Heine Beta 200 Streak Retinoscope 3.5v w/Twist Lock for Welch-Allyn style handles.,medicine,medical supply,medical supplies,medical product
Funky Streaks most recent addition to the line-up of semi-permanent hair color brands. Funky Streaks feedback on Sparks and Pravana is that they come in a creamy form that smells like cologne. They are highly pigmented so a little goes a long way, and best of all, it lasts a really long time even with regular washing. However, you may have to bear with color bleed for the first four weeks or so. ...
Ethanol snapped the longest streak of gains against gasoline in five weeks as prices for the motor fuel rose for the first time in four days.
The following images have CCs actual as the lighter colour next to their expected result (i.e. what perfectly distributed, non-random, dice statistically SHOULD be) as the darker colour and are sorted as Win/Draw/Loss or Win/Loss streaks. They are then sorted by runs of 1 through 30 (so the tall columns are runs of 1 while the small columns are runs of 30 ...
Find out details on the rock climbing route named Survival Streak, including topos, photos, user reviews, and route info such as climbing type and grade.
The Glastonbury girls' 63-game regular season winning streak came to a halt in untraditional fashion, via a 0-0 tie with Tolland on Sept. 19, which marked the
The streak is over. Well, that didnt take long. I made it 26 days straight for my run-streak. My best streaking attempt was 101 days. This time, I thought I would make it to January 1st (39 days), then decide whether to continue. Guess I dont need to make that decision now! Im not streaking. Its over. And I feel good about it. Yesterday, I skipped my morning run thinking Id do a few loops of the neighborhood after work. Well, after work I was tired and hungry, so I ate (and drank beer), but did not run. In fact, I napped for about 30 minutes after eating. Woke up, pondered going for a run, then watched TV and read until falling asleep again. No run ...
Manchester United halted their three-match losing streak as second-half goals from Antonio Valencia and Danny Welbeck eased the pressure on beleaguered manager David Moyes.
Arsenal and Manchester City were both treated to late winners, while Liverpool threw away another lead after a shot (or was it?) from Willian and Gylfi Sigurdsson hit just about everything en route to a goal for Everton on an action-packed weekend.
Matt The Law Lindland snapped a two fight losing streak with a technical knockout win over Kevin Casey in the main event of ShoMMA 8: Lindland vs. Casey at
I am a 40 years old man suffered from choroidal neovascular membrane (CNVM) 2 years back in the right eye. I took Avastin at that time. The blood dried but it left a scar on that place and I lost the vision of my right eye. Now |b|I have developed black spots and lines in my other eye too|/b|, which is causing pain in both the eyes and I am facing problem in reading too. How can I save my left eye? Is there any treatment for the CNVM scar?
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The abcc6a Gene Expression Is Required for Normal Zebrafish Development. Qiaoli Li; Sadowski, Sara; Frank, Michael; Chai, Chunli; Váradi, Andras; Shiu-Ying Ho; Hong Lou; Dean, Michael; Thisse, Christine; Thisse, Bernard; Uitto, Jouni // Journal of Investigative Dermatology;Nov2010, Vol. 130 Issue 11, p2561 Pseudoxanthoma elasticum (PXE) is caused by mutations in the ABCC6 gene, which encodes a putative efflux transporter, ABCC6. The zebrafish (Danio rerio) has two ABCC6-related sequences. To study the function of abcc6 during zebrafish development, the mRNA expression levels were measured using... ...
NEW YORK -- Orioles manager Buck Showalter says his team works to be "brilliant in the basics." Baltimore limits errors and capitalizes on opportunities -- its why the Os entered the American League Division Series with a 74-0 record when leading after seven innings and, more appropriate for Wednesday night, as winners of 16 straight extra-inning games. Both streaks are now over, the former ending Sunday after the Yankees five-run ninth inning in Game 1, and the latter when Raul Ibanez hit a walk-off home run in the 12th inning of Game 3 Wednesday night at Yankee Stadium. "Its very hard to do what these young men do for a living," Showalter said. "It doesnt always work out perfectly, and thats part of it -- its happened at times during the year, and its part of the process." On paper, the Orioles felt good about coming into Yankee Stadium needing to win two of three. Baltimore was the only team to post a winning record against the Yankees in the Bronx this season, taking all three series ...
Germ layers and body axes of a vertebrate embryo are established under the influence of a regulatory center, the embryonic organizer. Secreted factors emanating from the organizer and from its derivatives lay down the identity of neighbouring cells and coordinate embryogenesis. The first part of this thesis examined the role of the murine gastrula organizer as a source of anterior neural plate inducing signals. In mammals the initiation of forebrain induction is based on signals from the extraembryonic anterior visceral endoderm. Additionally, as shown in this study, signals from the tip of the primitive streak are necessary and sufficient for the establishment of a stable forebrain identity. The results led to a modification of the hypothesis on temporally and spatially separated head and trunk organizers in the mammalian embryo. Anterior neural induction can therefore be described as an extended activation-transformation model. Neural identity is initiated by extraembryonic endoderm and ...
Stanford will have to meet UConn one more time this year, and it will count for a lot more. Stanford broke the streak, but it was already a record. With Stanfords coach letting it slip that they spent a lot of extra time preparing for UConn, it will definitely make UConn extremely motivated when they meet in the late rounds of the NCAA tournament in March. If Stanford had played them close and lost, or their coach hadnt let it slip that they spent extra time preparing for them, UConn probably would have just moved on. Now, though, they will be gunning for Stanford as bad as Stanford was for them when they meet them in the tournament. I know I am assuming a lot when I say they will meet, but both teams really should make it to the Final Four. Anyway, the streak was good for womens hoops, and the streak being broken was good for womens hoops, so everybody won tonight: even UConn. Im sure it doesnt feel that way to them right now, though.. ...
1. Streak different bait strains in horizontal parallel stripes on a -u-h Glu plate. Streaks should be at least 3 mm wide and at least 5 mm apart, with the first streak starting about 15 mm from the edge of the plate. A 100 mm plate (which for some reason is typically 90 mm in diameter) will hold 8 different bait strains. Create a duplicate plate of bait strains for each different plate of prey strains to be used. 2. Likewise, streak different prey strains in vertical parallel stripes on a -w Glu plate. As a control for baits that may activate transcription, include a prey strain that contains the prey vector pJG4-5 not encoding a fusion protein (i.e. encoding only the activation domain). Create a duplicate plate of prey strains for each plate of bait strains to be used. 3. Incubate plates at 30oC until there is heavy growth on the streaks. When taken from reasonably fresh cultures, for example plates that have been stored at 4oC for less than a month, streaked RFY206-derived bait strains take ...
Hello, I noticed this brown patch on my nose on Sunday, it has a dark patch then an a ring surrounding around the patch or streaks going out of it, i have kept an eye on it, and it hasnt changed and it...
Okay guys lately whenever i look out the back of my window outside on the second story of my house i have been seeing these strange purple streaks of light ...
Results Clinical examination showed shoulder pain in 24% of cases, signs of rotator cuff disease in 38% (subacromial impingement, tendinopathy or tear). Pain was negatively correlated with retirement and sports (p,0.05). US examination found abnormalities in 93% of cases: enthesophytes in 64%, long head of the biceps disorder in 40% (synovial effusion, thickening, abnormal power Doppler signal), tendinous calcifications in 28%. There were more enthesophytes in painful patients, but the correlation did not reach significance (90.9% vs 55.6%, p = 0.06). There was no correlation between clinical signs and US abnormalities. Using logistic regression, we found that only age was associated with having tendinous calcification (OR = 1.08/year ie 1.46/5years, p=0.008) or enthesophytes (OR= 1.09/year ie 1.53/5years, p=0.007).. ...
Pathologists have long observed that early stages of human vascular calcification occur along the edges and frayed ends of elastin fibers.52 As noted earlier, elastin haploinsufficiency reduces the vascular calcification associated with MGP deficiency in mice.39 The authors interpreted this finding to mean that MGP either protects mineralization initiation sites on elastin or alters extracellular matrix. These findings suggest that, in the context of MGP insufficiency, elastin calcification is metabolic in origin and that metabolic mineralization may lead to osteochondrogenic differentiation. Results showed a reduction in calcification and an increase in life span.39 The potential importance of elastin in other forms of vascular calcification is supported by its role as the target of calcification in the hereditary human disease, pseudoxanthoma elasticum (PXE), described below.. Clues about the role of elastin in metabolic vascular calcification come from the hereditary human disorder, PXE, ...
Of course, all of that is just probability. Here is the reality of what DiMaggio did 70 years ago. During his famous streak, DiMaggio had 91 hits, including 22 multi-hit games, and posted a .408 batting average. He hit 15 home runs and drove in 55 runs.. But here are the numbers that separate DiMaggio from Ethier and every other player in baseball history: During the 56-game streak, DiMaggio struck out a grand total of five times. Five!. During the entire 1941 season, he stuck out 13 times, in 621 plate appearances and 541 at-bats.. During his 29-game hitting streak, Ethier has already whiffed 20 times. The Rockies Dexter Fowler has already struck out 35 times in 103 at-bats this season, and teammate Chris Iannetta has whiffed 24 times in just 60 at-bats.. Trivia time. Who owns the Rockies record for the longest consecutive game hitting streak? (Answer below). Quotable. "Only halfway? Its nothing to get too caught up in or too excited about right now.". - Ethier, talking to reporters after ...
Question - Streaks of blood in sputum. Advised neosprin for injury inside nose. Chest Xray,CBC normal. Sputum blood streaks again. Causes?. Ask a Doctor about when and why X ray is advised, Ask an ENT Specialist
The relatively high concentration in this pilot study was to be sure that the DHT receptors would all be blocked. The alcohol and water vehicle used in this pilot study was chosen in order to be certain that any beneficial effects would be from Ethocyn rather than from the vehicle. The tissue was stained with Verhoeffs stain so that the elastin stained black. At the end of the study the slides were randomized so that it was not known which slide was from which patient at which time and then photographed through the microscope with a camera which allowed the images to be stored on a computer. Computer image analysis was then performed to determine the percentage of surface area of each slide which took up the elastic tissue stain. After breaking the code it was found that the average increase in elastic tissue was about 100% as measured by computer image analysis. The findings of this study were statistically significant at a level of p ...
LONDON (MarketWatch) -- European shares gained ground on Thursday, breaking a two-session losing streak, as investors took comfort from some well-received...
My cleaners are leaving my floors with streaks after they have mopped and the floor has dried. The floors are jarrah polished floor boards. Any ideas what they are doing wrong?
Meetu - thanks :) I am not a very good photographer yet. What I try to do is to have my camera with me ALL THE TIME. Whenever I see something that appears beautiful, I try to capture it. Ive observed that the photo does not look anywhere near to the beautiful thing you saw with your eyes. This happens many times. But with some time, we just know how a photo would look almost close to what we saw in reality.. ReplyDelete ...
POLITICO Pro provides the most distinct coverage of Brussels and beyond, and thousands of politics and policy professionals depend on us each day to do their jobs.. Request a trial here. Or email [email protected] or call +32 2 548 15 20 for more information.. Already a Pro? Log in here.. ...
Even after Ohio State cornerback Chimdi Chekwa was told about the Buckeyes bowl futility against teams from the Southeastern Conference, he had a hard time believing it.
No sign of my period. Just two maddening streaks of pink two days ago. Dont worry, the internet has informed me that: implantation bleeding doesnt exist. That it exists only right before your period. That it can happen as early as 3 days post ovulation. That only 30% of women get it. That NO women…
My lucky streak with toilets -- running about 4 years now, was broken when my Raritan Sea Era broke down a few days ago The seal plate somehow fused to the impeller, which jammed up the
PURPOSE: Because several polypeptide growth factors are known to influence capillary endothelial cell mitogenesis, the authors investigated the presence of some of these molecules in choroidal neovascular membranes (CNVMs) removed surgically from human subjects with age-related macular degeneration (ARMD). METHODS: The authors performed immunoelectron microscopic studies on surgically removed submacular CNVMs from nine subjects with ARMD and from one subject with ARMD whose eye was studied after death. These were compared with retinal pigment epithelial (RPE) and choroidal tissue from eight normal subjects whose eyes were received after death and one received after massive trauma. RESULTS: RPE cells from the CNVMs were strongly immunoreactive for acidic and basic fibroblast growth factor (aFGF and bFGF) and for transforming growth factor beta (TGF beta). Some of the immunoreactivity was intracytoplasmic, but most was intralysosomal. In addition, some choriocapillary endothelial cells located ...
For Lasik, cataract surgery and general eye care, Eye Clinic & Laser Institute has been serving Merritt Island, Cocoa Beach, Melbourne-Palm Bay, Viera, Titusville and Brevard County since 1980. We were the first to bring LASIK to our local community in 1997 and are the only eye surgeons in Brevard to provide BLADELESS CATARACT LASER SURGERY (2013).
Normophosphataemic familial tumoral calcinosis, charac-terized by ectopic mineralization of skin, is caused by mutations in the SAMD9 gene located in human chromosome 7q21, next to a paralogous gene, SAMD9-like (SAMD9L). The mouse does not have a SAMD9 orthologue, Samd9, because it has been deleted during evolution owing to genomic rearrangements. It has been suggested that the mouse Samd9l gene serves as a functional paralogue of human SAMD9. In this study, we examined Samd9l knockout mice with respect to ectopic mineralization. We also crossed these mice with Abcc6(tm1JfK) mice, a model system to study pseudoxanthoma elasticum, to see whether the absence of the Samd9l gene modifies the mineralization process. Necropsy analysis of Samd9l(tm1Homy) mice revealed no evidence of ectopic mineralization, and deletion of the Samd9l gene in mice failed to modify the mineralization process on the Abcc6(tm1JfK) background. Collectively, the results suggest that mouse Samd9l is not a functional paralogue of human
Michael Nylanders streak of playing 310 consecutive games ended during practice yesterday with a broken right ankle that will sideline the Washington Capitals first-line center four-to-six weeks.
What is your longest running streak? Most of us dont think about this as we take a rest day here or there, but let me introduce to John, our resident streak runner. John works at the store, and youve probably seen him either here or out with the Seattle Running Club. One really fun fact about John is that hes been running every SINGLE day since he was a boy. And tomorrow is his 9000th day (over 24 years) of running every day. Hes inviting folks to join him and enter the miles you run tomorrow on his tracker. Hes hoping to reach 9000 miles amongst his community of runners. Keep reading to learn about streak running, the craziest things hes every done to fit a run in, and of course, how to count your miles towards his 9000th day!. What was your very first day of your running streak? ...
The Anaheim Ducks on Monday responded to a challenge from their captain, ending their own losing ways while also halting the New York Islanders franchise-best 17-game point streak.
George Caldwell: You stupid, ignorant son of a bitch, dumb bastard. Jesus Christ. Ive met some dumb bastards in my time but you outdo them all.
Liversedge ended a 10-match losing run in the Northern Counties East League Premier Division last Saturday as they sealed a thrilling 4-3 victory over Barton Town Old Boys.
A Michigan couple who already had 12 sons have kept the all-male streak alive with the birth of boy No. 13. Jay Schwandt says his wife Kateri gave birth yesterday morning, four days after her due date.... US News Summaries. | Newser
Barely eking out a gain yesterday, the index is now up 5 straight days heading into todays session. Even though it has been nearly a straight ride up for the markets over the last 2 months, the S&Ps current winning streak is its longest since July, when it was up 6 straight days.
Staring hard at the live streaming video of the black Australian skies, I was hoping to see a faint streak of light glide across the cameras field of view. But no, it wasnt that subtle. Shortly after 9:51 am EDT on Sunday morning (or, for me, a far more civilized 2:51 pm GMT), the Japanese…
Mönckebergs arteriosclerosis, or Mönckebergs sclerosis, also called medial calcific sclerosis or Mönckeberg medial sclerosis, is a form of arteriosclerosis or vessel hardening, where calcium deposits are found in the muscular middle layer of the walls of arteries (the tunica media). It is an example of dystrophic calcification. This condition occurs as an age-related degenerative process. However, it can occur in pseudoxanthoma elasticum and idiopathic arterial calcification of infancy as a pathological condition, as well. Its clinical significance and cause are not well understood and its relationship to atherosclerosis and other forms of vascular calcification are the subject of disagreement. Mönckebergs arteriosclerosis is named after Johann Georg Mönckeberg, who first described it in 1903. Typically, Mönckebergs arteriosclerosis is not associated with symptoms unless complicated by atherosclerosis, calciphylaxis, or accompanied by some other disease. However presence of ...
Two weeks ago, I reported about a new Dell Streak malware infection plaguing the Android Market called DroidDreamLight. While many Streak users were worried by the outbreak of this new virus and its predecessor, DroidDream, Android malware was still regarded as a relative anomaly.. Well, unfortunately for us Streak lovers, it appears that once again were at risk of getting one of two new Android viruses, Plankton and YZHCSMS, via the download of a seemingly legitimate app from the Android market.. Plankton is a super-stealthy piece of malware that, upon being downloaded to your phone with a legitimate application, accesses your Device ID, along with all the permissions youve allowed the app to access, and sends them off. Plankton is then sent a payload that runs and uses the host apps permissions to access runtime browsing information, bookmarks, and information about the inner workings of your Streak.. Plankton also appears to be capable of delivering more bad software to your unsuspecting ...
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Boat Cleaners & Waxes - Glass Compatibility > Stain & Streak Removers Type - Since 1998, iboats is the most trusted water lifestyle online store for boat parts and accessories, boats for sale, and forums. Enjoy great priced products with fast shipping.
There was apparently a second conference after batting practice, where Ethier had changed his mind.. [Update at 4:38 p.m.: Ethier said he originally hurt the elbow on April 16, when he scored from third on a James Loney bouncer to Cardinals first baseman Albert Pujols, who fired home. Ethier used a wide slide and reached in with his hand to score.. I dont know if I hyper extended it or jammed my elbow reaching for home plate, Ethier said. Its been on and off the last couple of weeks, but the last couple of days its been worse.. Etheir said he told Mattingly he was willing to risk his hitting streak and pinch-hit Wednesday if the situation called for it.. Its more tender on the throwing than it is the swinging, he said. After I take five or six hacks, it loosens up pretty nicely but throwing is still pretty sore.. Ethier said he is scheduled to have the elbow examined Thursday after the Dodgers arrive in New York by Dr. Neal ElAttrache, the team doctor who happens to be in New ...
Missed opportunities, a battle-weary goalie and a final assault by nemesis Phil Kessel steamrollered the Ducks and their seven-game winning streak Tuesday night. The Toronto Maple Leafs, on a 10-1-1 run of their own, leaned on a 40-save effort by former Kings goalie Jonathan Bernier and dealt Anaheim...
Question - Mole inside the cheek seems to have grown with purple streaks surrounding it. Cancer sign?. Ask a Doctor about diagnosis, treatment and medication for Mucous cyst, Ask a Dermatologist
Im sure I heard that they were adding those little zipped bags to the trains for loose articles? I guess not, then... This is such a cheap and tacky way...
This may be a few innings late but, how about when Peter Gammons validated Morgans point about Youks hitting streak by saying Youk did not think he would have a long hitting streak because he walked so much and then you could almost see Morgans ego getting inflated and he talked about it for the rest of the inning. ...
This may be a few innings late but, how about when Peter Gammons validated Morgans point about Youks hitting streak by saying Youk did not think he would have a long hitting streak because he walked so much and then you could almost see Morgans ego getting inflated and he talked about it for the rest of the inning. ...
Contrast is a great game, with a few hiccups that keep it from being perfect. The 3D world and shadow world are great ideas, and a unique tale of shadows, a little girl, and an imaginary friend will keep you intrigued till the very end. ...
TORONTO -- After the Toronto Maple Leafs played a poor first period Tuesday against the Anaheim Ducks, coach Randy Carlyle delivered a simple message.
TORONTO -- After the Toronto Maple Leafs played a poor first period Tuesday against the Anaheim Ducks, coach Randy Carlyle delivered a simple message.
The webs technology news site of record, Techmeme spotlights the hottest tech stories from all around the web on a single page.
A new number one this week, the Rangers prove to be leaders as they are on a four-game winning streak. The Red Sox fell behind and are now seventh in the rankings. - Mare McKeever
Sweet moves up the beautiful bacon streaks, Such a good line. I climbed the route ground up on my 2nd go. Should have flashed really but happy all the same. Probably soft 8a, no more. So good I did it twice. ...
The structure was refined using the CNS program. The R value is 0.0 for 40729 reflections in the resolution range 50.0 to 2.0 Ångstroms with Fobs , 0.0 sigma(Fobs) and with I , 0.0 sigma(I) ...
Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography Magdy Moussa,1,2 Mahmoud Leila,3 Hagar Khalid1,2 1Ophthalmology Department, Faculty of Medicine, Tanta University, Tanta, Egypt; 2MEDIC Eye Center, Tanta, Egypt; 3Retina Department, Research Institute of Ophthalmology, Giza, Egypt Purpose: The aim of this study was to assess the efficacy of swept-source optical coherence tomography angiography (SS-OCTA) in delineating the morphology of choroidal neovascular membrane (CNV). Patients and methods: This was a retrospective observational case series reviewing clinical data and fundus fluorescein angiography (FFA), swept-source optical coherence tomography (SS-OCT), and SS-OCTA images of patients with CNV and comparing the findings. The swept-source technology enables deeper penetration and superior axial resolution. The incorporated blood flow detection algorithm, optical coherence tomography angiography ratio analysis (OCTARA), enables visualization
It is relatively rare to obtain histology of CNV treated after PDT. Ghazi et al5 and Schnurrbusch et al6 reported the histological findings in surgically excised classic CNV treated with PDT. Ghazi et al studied one specimen by electron microscopy. The authors concluded that PDT causes endothelial cell damage, thrombus formation, and vascular occlusion. Schnurrbusch et al studied two recurrent CNV. The authors concluded that the evidence of fluorescein leakage from the CNV and enlargement of the neovascular complex following PDT could be related to new vessel growth and recanalisation of occluded vessels. RPE disturbances were thought to be related to the original pathology or as a result of PDT. Our specimen appeared to lack vessels where the RPE cell layer was fragmented but was vascular where the RPE cell layer was intact. These two regions may correspond to the original (PDT treated) CNV and its recurrence respectively. Bynoe et al have described the non-even distribution of blood vessels ...
1. Grafts consisting of pieces of primitive streak from blastoderms in the primitive streak stage were placed under the primitive streak of blastoderms also in this stage.. 2. Various effects of the host on the graft are described, particularly the reversal of the antero-posterior orientation of the graft, the alteration of the regional character of the graft so as to conform with the host tissues at the same level, the suppression of differentiation in the posterior end of the primitive streak, and the incorporation of the graft tissues into the host.. 3. A considerable number of inductions occurred, since the host axis often apparently shifts to one side of the graft. The inductions are of two kinds, the normal evocation by graft mesoderm, resulting usually in the formation of superfluous neural tissue; and the complementary induction of a normal secondary axis, which it is supposed is most often due to the preliminary induction of a primitive streak in the host.. 4. Various effects of the ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Background. We sought to determine the prevalence of skin conditions traditionally associated with acute ischemic stroke (AIS) and transient ischemic attacks (TIA) in the U.S.. Methods. This is a cross-sectional study of data derived from the National Inpatient Sample from 1988-2008. We searched for admissions of patients ,18 years, with a primary diagnosis of AIS, TIA, and the following secondary diagnoses (dermatoses): Psoriasis, Behcets Disease (BD), Dermatomyositis (DM), Systemic Lupus Eythematosis (SLE), Pseudoxanthoma Elasticum (PXE), Progressive Systemic Sclerosis or Scleroderma (SCD), and Bullous Pemphigoid (BP). Definitions were based on ICD9CM codes, and adjusted incidence rates for the U.S census and prevalence proportions were then calculated.. Results. Over the 20-year period, we identified 9,085,147 admissions that corresponded to a primary diagnosis of AIS and TIA of which 53,060 had a secondary diagnosis of dermatoses, for a total prevalence of 0.6%. The adjusted rate of AIS/TIA ...
Angioid streaks may develop, possibly as a result of calcification of collagen or other pathological deposition. ...
... angioid streaks) that radiate out from the optic nerve. Angioid streaks themselves do not cause distortion of vision, even if ... The diagnostic criteria for PXE are the typical skin biopsy appearance and the presence of angioid streaks in the retina. Other ...
The inherited disorder pseudoxanthoma elasticum may lead to angioid streaks with calcification of Bruch's membrane, the elastic ...
... angioid streaks MeSH C11.768.257 --- diabetic retinopathy MeSH C11.768.328 --- epiretinal membrane MeSH C11.768.400 --- retinal ...
"Knapp streaks"; also known as angioid streaks, which are tiny breaks in the elastin-filled tissue in the back of the eye. He ...
... in the eye due to breaks in Bruch's Membrane called angioid streaks, which are common in pseudoxanthoma elasticum, or in ...
... he was the first physician to describe angioid streaks, a disorder that affects Bruch's membrane, the innermost layer of the ...
... angioid streaks (H35.3) (H31.2) Hereditary choroidal dystrophy Choroideremia Dystrophy, choroidal (central areolar) ( ...
Associated conditions such as angioid streaks and retinitis pigmentosa should be screened for. Both the severity of optic disc ... Certain conditions have been associated with disc drusen such as retinitis pigmentosa, angioid streaks, Usher syndrome, Noonan ...
eMedicine article on Angioid streaks Photos of Angioid streaks DermAtlas Archived June 7, 2012, at the Wayback Machine. - Johns ... Angioid streaks, also called Knapp streaks or Knapp striae are small breaks in Bruch's membrane, an elastic tissue containing ... Angioid streaks are often associated with pseudoxanthoma elasticum (PXE), but have been found to occur in conjunction with ... A few years later, ophthalmologist Hermann Jakob Knapp called them "angioid streaks" because of their resemblance to blood ...
Pseudoxanthoma elasticum and angioid streaks: a review of 106 cases. Am J Med 30:537-543, 1961 3. Dixon JM: Angioid streaks and ... Changes in the eyes in PXE consist of angioid streaks of the fundus due to ruptures in Brucks membrane of the choroid which ... St 1. Carlborg U, Ejrup B, Gronblad E, et al: Vascular studies in pseudoxanthoma elasticum and angioid streaks. Acta Med Scand ... Am J Med 27:433-442, 1959 9. Scheie H G , Freeman NE: Vascular diseases associated with angioid streaks of retina and ...
Long-term control of choroidal neovascularization secondary to angioid streaks treated with intravitreal Bevacizumab (Avastin®) ... Long-term control of choroidal neovascularization secondary to angioid streaks treated with intravitreal Bevacizumab (Avastin®) ... associated with angioid streaks (AS).. Methods: Patients with unilateral active CNV associated with AS were enrolled. Exclusion ...
... photodynamic therapy combined with intravitreal triamcinolone for choroidal neovascularization due to angioid streaks Alfredo ...
... as well as angioid streaks of the retina [19],[21],[22]. Angioid streaks represent linear breaks in areas of calcification of ... McPhaul JJ, Engel FL: Heterotopic calcification, hyperphosphatemia and angioid streaks of the retina. Am J Med. 1961, 31: 488- ... Geeraets WJ, Guerry D: Angioid streaks and sicklecell disease. Am J Ophthalmol. 1960, 49: 450-470. 10.1016/0002-9394(60)91645-7 ...
Lim JI, Bressler NM, Marsh MJ, Bressler SB: Laser treatment of choroidal neovascularization in patients with angioid streaks. ...
angioid streaks. *anisometropia. *anitoxidants. *anti-VEGF. *antioxidants. *antiVEGF. *Apple. *Architecture. *Archives of ...
... polyposis Endometrial carcinoma Varicocele Trichilemmoma Thyroid adenoma Intestinal polyp Ovarian carcinoma Angioid streaks of ...
Angioid Streaks. *Chorioretinal Folds. *Degenerative Retinoschisis. *Proliferative Vitreoretinopathy. *Retinal Detachment. * ...
ageangiodAngioidangioid streaksblood vesselsbruchcausal connectionscollagenconnective tissuecracksdamagediseaseehlers danlos ... Angioid Streaks Retina 970-226-0959 Dr. Kisling. June 13, 2009. Eye Diseases, Fort Collins Eye Doctor, Fort Collins Optometrist ... Angioid Streaks In The Retina These images are pictures of the retina inside the back of the eye where the … ... eye imagegenetic disorderimageslayerlossmembraneNEIophthalmic imagingPseudoxanthomapseudoxanthomaelasticumRetinasteaksStreaks ...
Argon Laser Photocoagulation of Choroidal Neovascularization Secondary to Angioid Streaks İbrahim TAŞKINTUNA1, Mehmet Y. TEKE1 ...
Angioid Streaks. *Chorioretinal Folds. *Degenerative Retinoschisis. *Proliferative Vitreoretinopathy. *Retinal Detachment. * ...
Grönblad-Strandberg syndrome - angioid streaks of the retina together with pseudoxanthoma elasticum of the skin. ...
Occlusions in the choroidal circulation with associated breaks in Bruchs membrane are known to cause angioid streaks, a ... Presence of comma-shaped blood vessels in the bulbar conjunctiva ("comma sign") and angioid streaks on funduscopic examination ...
Intravitreal Bevacizumab for the Treatment of ecurrent Choroidal Neovascular Membrane Secondary to Angioid Streak Fatih ÖZCURA1 ... Intravitreal Bevacizumab Injection in Submacular Choroidal Neovascularization due to Angioid Streaks Fevzi ŞENTÜRK1, Hakan ... Intravitreal Aflibercept Treatment For Extrafoveal Choroidal Neovascularization Secondary To Angioid Streaks Related To ...
Angioid Streaks. *Anterior Ischemic Optic Neuropathy (AION). *Choroidal Nevus & CHRPE. *Central Serous Retinopathy (CSR) ...
Adult , Aged , Female , Humans , Male , Middle Aged , Angioid Streaks/complications , Choroidal Neovascularization/drug therapy ... CONCLUSION: Photothrombosis is a feasible procedure for choroidal neovascularization secondary to angioid streaks. Lesion ... Indocyanine green-mediated photothrombosis for choroidal neovascularization in angioid streaks / Fototrombose mediada por ... with an average age of 70 years were diagnosed to have subfoveal choroidal neovascularization secondary to angioid streaks. ...
angioid streaks, retina conjunctival irritation conjunctival whitish salt-like deposits Skeletal:. tumoral calcinosis ectopic ... Heterotopic calcification, hyperphosphatemia and angioid streaks of the retina. 24 56 6 ... or angioid streaks that occur when tiny breaks form in the layer of tissue at the back of the eye called Bruchs membrane. ...
... angioid streaks, pathologic myopia and idiphatic causes by transpupilary thermoteraphy Nehemy, Márcio; Rodrigues, Rochelle ...
Angioid streaks in a case of peripheral arterial elastic tissue degeneration (Monkebergs degeneration).. Patil, S N; Kate, S; ...
Angioid streaks.. Paul, A K. 1-Feb-1984. Antifungal actinomycetes in soils of West Bengal.. Paul, A K; Banerjee, A K. ...
Angioid streaks of the fundus. 0001102 Autosomal dominant. inheritance. 0000006 Breast carcinoma. Breast cancer ...
Optic nerve drusen and angioid streaks in pseudoxanthoma elasticum]. Munteanu M, Chercotä V. Munteanu M, et al. Oftalmologia. ...
Angioid Myopic Macular Degeneration, Pattern Dystrophy, Other CNVM (Angioid Streaks, Idiopathic, Optic Nerve Drusen). ...
H35.33 Angioid streaks of macula H35.341 Macular cyst, hole, or pseudohole, right eye H35.342 Macular cyst, hole, or pseudohole ...
... , a medical condition affecting the human eye. This is part of a set of pages about conditions, diseases, and disorders of the human eye and visual system.
  • [ 1 ] Angioid streaks, also known as Knapp striae, are irregular jagged dehiscences in the mineralized, degenerated, brittle Bruch membrane that typically form alongside force lines exerted by intrinsic and extrinsic ocular muscles that radiate in a centrifugal pattern emanating from the optic disc. (medscape.com)
  • Angioid streaks demonstrating irregular concentric and some fine radial streaks associated with interconnected circular breaks near the optic disc. (drugster.info)
  • Each patient underwent a full dermatological examination and was investigated for diseases known to be associated with angioid streaks. (dundee.ac.uk)
  • No other diseases associated with angioid streaks were identified. (dundee.ac.uk)
  • In several past case studies examined by the Wills Eye Hospital in Philadelphia, angioid streaks have been misdiagnosed as other degenerative or inflammatory diseases including ocular histoplasmosis, ocular toxoplasmosis, myopia, and retinal vasculitis. (lowvisiontechnologies.com)
  • Posterior segment examination of the left eye showed pigmentary changes and gray linear lesions that radiated outward from the peri-papillary area which were compatible with angioid streaks. (scirp.org)
  • Fundus examination of the fellow eye showed angioid streaks with one of the breaks passing through the fovea. (scirp.org)
  • Although mutations of this gene are clearly associated with angioid streaks, the mechanism by which the transporter affects development of this pathology is speculative. (ochsnerjournal.org)
  • Early diagnosis is essential to helping prevent the worsening of angioid streaks and the development of CNV vessels. (lowvisiontechnologies.com)
  • If you have angioid streaks in one or both eyes, it is possible to remain asymptomatic and maintain perfect vision for a long time. (lowvisiontechnologies.com)
  • these signs included angioid streaks and pseudoxanthomatous skin lesions. (cdc.gov)
  • However, in both cases flexural skin elsewhere showed the typical clinical and histological features of PXE.Conclusions This study demonstrates the association between angioid streaks and PXE. (dundee.ac.uk)
  • also known as angioid streaks, which are tiny breaks in the elastin-filled tissue in the back of the eye. (wikipedia.org)
  • In general, angioid streaks are rare, but they are sometimes confused with other, more common conditions due to the range of appearance and clinical characteristics. (lowvisiontechnologies.com)
  • It is important to visit your optometrist on a regular basis so that any issues such as angioid streaks can be caught early on. (lowvisiontechnologies.com)
  • Conclusions This study demonstrates the association between angioid streaks and PXE. (dundee.ac.uk)