Angiogenic Proteins: Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.Cysteine-Rich Protein 61: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It may play an important role in the development of branched CAPILLARIES during EMBRYOGENESIS.Angiogenesis Inducing Agents: Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Neovascularization, Physiologic: The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Vascular Endothelial Growth Factor Receptor-1: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.Vascular Endothelial Growth Factors: A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.Endothelial Growth Factors: These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Lymphokines: Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.Fibroblast Growth Factor 2: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).Angiogenesis Inhibitors: Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Vascular Endothelial Growth Factor Receptor-2: A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.Angiopoietin-1: The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.Angiopoietin-2: An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.Pregnancy Proteins: Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)Blood Vessels: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).Periodontal Atrophy: Degradation or wasting of the PERIODONTIUM tissues that may involve the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, or the PERIODONTAL LIGAMENT.Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Hypertension, Pregnancy-Induced: A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.Federal Government: The level of governmental organization and function at the national or country-wide level.Government: The complex of political institutions, laws, and customs through which the function of governing is carried out in a specific political unit.United StatesGovernment Regulation: Exercise of governmental authority to control conduct.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Neoplasms, Glandular and Epithelial: Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.Factor VIII: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.Unfolded Protein Response: A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Cell Line, Tumor: A cell line derived from cultured tumor cells.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Shear Strength: The internal resistance of a material to moving some parts of it parallel to a fixed plane, in contrast to stretching (TENSILE STRENGTH) or compression (COMPRESSIVE STRENGTH). Ionic crystals are brittle because, when subjected to shear, ions of the same charge are brought next to each other, which causes repulsion.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Protein Tyrosine Phosphatases: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.Eclipta: A plant genus of the family ASTERACEAE. Members contain wedelolactone.Hydroxamic Acids: A class of weak acids with the general formula R-CONHOH.Human Umbilical Vein Endothelial Cells: Endothelial cells that line venous vessels of the UMBILICAL CORD.Chorioallantoic Membrane: A highly vascularized extra-embryonic membrane, formed by the fusion of the CHORION and the ALLANTOIS. It is mostly found in BIRDS and REPTILES. It serves as a model for studying tumor or cell biology, such as angiogenesis and TISSUE TRANSPLANTATION.Drug Repositioning: The deliberate and methodical practice of finding new applications for existing drugs.Peripheral Arterial Disease: Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.Peripheral Vascular Diseases: Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Protein Interaction Mapping: Methods for determining interaction between PROTEINS.Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.Protein Interaction Maps: Graphs representing sets of measurable, non-covalent physical contacts with specific PROTEINS in living organisms or in cells.Glycosylation End Products, Advanced: Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Hemophilia A: The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.Hindlimb: Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)

Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. (1/368)

Angiogenesis is required for the growth and progression of malignancies. Recent studies have demonstrated that genetic alterations may accompany acquisition of the angiogenic phenotype. The tumor suppressor gene p53 is most frequently mutated in human cancers and is also known to be a transcriptional regulator of a variety of genes. Here, we investigated the antiangiogenic effect of the wild-type p53 (wt-p53) gene transfer on a human non-small cell lung cancer cell line. Mutant p53-expressing H226Br non-small cell lung cancer cells were transduced with the wt-p53 gene using a recombinant adenoviral vector (Ad5CMVp53) and applied to semiquantitative reverse transcription-PCRs for the detection of altered mRNA expression of angiogenic and/or antiangiogenic factors. In vivo neovascularization assay of Ad5CMVp53-infected cells was then performed using a membrane-diffusion chamber system s.c. transplanted in nu/nu mice. We also evaluated the effect of Ad5CMVp53-infected H226Br cells on nontransduced tumor cells in vivo by s.c. inoculating mixture of cells into nu/nu mice. Ad5CMVp53 infection markedly inhibited the expression of an angiogenic factor, vascular endothelial growth factor, and increased the expression of a novel antiangiogenic factor, brain-specific angiogenesis inhibitor 1, resulting in reduced neovascularization in vivo. Mixing experiments showed that tumor cells transduced with the wt-p53 gene inhibited the in vivo tumor growth of adjacent nontransduced cells. Our data suggest that a recombinant adenovirus expressing the wt-p53 gene is antiangiogenic, which may explain, in part, the mechanism of the bystander effect induced by the wt-p53 gene transfer on adjacent tumor cells.  (+info)

Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: differential effect on proliferating endothelial cells. (2/368)

Vascular endothelial growth factor (VEGF) plays an important role in tumour angiogenesis. VEGF binds to tyrosine kinase receptors, which are expressed almost exclusively on tumour endothelium. Therefore, VEGF can be used to target toxin molecules to tumour vessels for anti-angiogenic therapy. However, recent evidence suggests that VEGF can also bind in an isoform-specific fashion to a newly identified neuropilin-1 (NP-1) receptor. NP-1 is widely expressed in normal tissue and presents a potential target for unwanted toxicity. As a consequence, we investigated whether the VEGF121 isoform, which lacks the NP-1 binding domain, could be used to target toxin polypeptides to tumour vasculature. Treatment of endothelial cells with a VEGF121-diphtheria toxin (DT385) conjugate selectively inhibited proliferating endothelial cells, whereas confluent cultures were completely resistant to the construct. In addition, VEGF121-DT385 conjugate treatment completely prevented tumour cell induced angiogenesis in vivo. Most importantly, the conjugate inhibited tumour growth in athymic mice and induced tumour-specific vascular damage. There was also no apparent toxicity associated with the treatment. Our results suggest that proliferating endothelial cells are highly sensitive to VEGF121-toxin conjugates and that the binding to NP-1 receptors is not necessary for efficient inhibition of tumour growth.  (+info)

Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer. (3/368)

The expression of interleukin 10 (IL-10) is correlated with clinical prognosis in non-small cell lung cancer [NSCLC (H. Hatanaka et al., ANN: ONCOL:, 11: 815--819, 2000)]. However, the effects of IL-10 expression on vascularization in NSCLC are not apparent. We examined the gene expression of IL-10/IL-10 receptor and various angiogenic/angioinhibitory factors in 95 NSCLC samples to determine the correlation between IL-10 production and vascularization. Vascular endothelial growth factor, angiopoietin [Ang (Ang-1 and Ang-2)], thrombospondin, brain-specific angiogenesis inhibitor 1, vascular endothelial growth factor receptors (KDR and flt-1), and Ang receptor (TIE2) gene expression were evaluated by reverse transcription-PCR. The cellular localization of these factors and vascularity in the cancer stroma were examined immunohistochemically. Seventy-eight (82.1%) and 93 (97.9%) of these 95 NSCLCs were positive for IL-10 and IL-10 receptor, respectively. Ang-1, Ang-2, and TIE2 gene expression was seen in 76 (97.4%), 73 (93.6%), and 78 (100%) of 78 IL-10-positive NSCLCs, respectively, and was significantly correlated with IL-10 gene expression (P < 0.0088, <0.0008, and 0.0305, respectively; Fisher's exact method). The localizations of Ang-1, Ang-2, and TIE2 were confirmed within tumor cells immunohistochemically. Vascular number and measurement area were significantly higher in the IL-10-positive NSCLCs (33.500 +/- 9.299/microm(2) and 4.742 +/- 1.287%) as compared with IL-10-negative NSCLCs (10.611 +/- 2.839/microm(2) and 0.718 +/- 0.331%; Mann-Whitney U test, P = 0.0039). The IL-10 expression did not show any significant correlation with the expression of other factors. These results suggested that tumor-produced IL-10 promotes stromal vascularization through expression of Ang-1, Ang-2, and TIE2.  (+info)

Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. (4/368)

The brain-specific angiogenesis inhibitor 1 gene has been isolated in an attempt to find fragments with p53 "functional" binding sites. As reported herein and by others, brain-specific angiogenesis inhibitor 1 expression is present in some normal tissues, but is reduced or lost in tumour tissues. Such data and its particular structure prompted the hypothesis that brain-specific angiogenesis inhibitor 1 may act as a mediator in the local angiogenesis balance. We herein demonstrate that brain-specific angiogenesis inhibitor 1 over-expression suppresses tumour angiogenesis, delaying significantly the human tumour growth in immunodeficient mice. The inhibitory effect of brain-specific angiogenesis inhibitor 1 was documented using our intravital microscopy system, strongly implicating brain-specific angiogenesis inhibitor 1 as a mediator in the control of tumour angiogenesis. In contrast, in vitro tumour cell proliferation was not inhibited by brain-specific angiogenesis inhibitor 1 transfection, whereas some level of cytotoxicity was assessed for endothelial cells. Immunohistochemical analysis of tumour samples confirmed a reduction in the microvessel density index in brain-specific angiogenesis inhibitor 1-overexpressing tumours. At messenger level, moderate changes could be detected, involving the down-regulation of vascular endothelial growth factor and collagenase-1 expression. Furthermore, brain-specific angiogenesis inhibitor 1 expression that was lost in a selection of human cancer cell lines could be restored by wild-type p53 adenoviral transfection. Brain-specific angiogenesis inhibitor 1 should be considered for gene therapy and development of efficient drugs based on endogenous antiangiogenic molecules.  (+info)

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. (5/368)

PDZ domains typically interact with the very carboxyl terminus of their binding partners. Type 1 PDZ domains usually require valine, leucine, or isoleucine at the very COOH-terminal (P(0)) position, and serine or threonine 2 residues upstream at P(-2). We quantitatively defined the contributions of carboxyl-terminal residues to binding selectivity of the prototypic interactions of the PDZ domains of postsynaptic density protein 95 (PSD-95) and its homolog synapse-associated protein 90 (SAP102) with the NR2b subunit of the N-methyl-d-aspartate-type glutamate receptor. Our studies indicate that all of the last five residues of NR2b contribute to the binding selectivity. Prominent were a requirement for glutamate or glutamine at P(-3) and for valine at P(0) for high affinity binding and a preference for threonine over serine at P(-2), in the context of the last 11 residues of the NR2b COOH terminus. This analysis predicts a COOH-terminal (E/Q)(S/T)XV consensus sequence for the strongest binding to the first two PDZ domains of PSD-95 and SAP102. A search of the human genome sequences for proteins with a COOH-terminal (E/Q)(S/T)XV motif yielded 50 proteins, many of which have not been previously identified as PSD-95 or SAP102 binding partners. Two of these proteins, brain-specific angiogenesis inhibitor 1 and protein kinase Calpha, co-immunoprecipitated with PSD-95 and SAP102 from rat brain extracts.  (+info)

Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (6/368)

Brain angiogenesis inhibitors (BAI) are putative transmembrane proteins containing an extracellular domain with thrombospondin type-1 repeats which can exhibit anti-angiogenic activity. BAI1 mRNA is expressed mainly in the brain, while BAI2 and BAI3 mRNAs are more widely expressed. We hypothesized that the BAI family might have anti-tumoral properties and studied the expression of BAI1 protein in normal human brain and in glioblastoma multiforme. We generated an anti-BAI1 antibody and showed that BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated. BAI1 expression did not correlate with TP53 status and we did not confirm previous findings that p53 regulates BAI1 mRNA expression in glioma cells. The finding that expression of BAI proteins may be lost during tumor formation is of special interest as restoration of their function in tumors may be of therapeutic benefit.  (+info)

Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. (7/368)

Vascular endothelial growth factor (VEGF)-mediated angiogenesis is essential for bone formation. However, the effect of VEGF on osteoblastic cells during osteoblastogenesis is still controversial. The aim of this study was to clarify the relationship between osteoblastic cells derived from human mesenchymal stem cells (MSCs) and VEGF in the early stage of osteoblastic differentiation. Continuous dexamethasone treatment with a low concentration stimulated osteoblastogenesis of MSCs and the expression of VEGF121 mRNA. The VEGF secretion from osteoblastic cells also increased along with osteoblastogenesis. Neuropilin-1, which mainly binds VEGF165, was detected at all stages during early osteoblastogenesis, but VEGF receptor-1 and -2 were not detected on RT-PCR analyses. In this study, VEGF had no direct effect on the proliferation of osteoblastic cells. However, the secreted VEGF in the conditioned medium of osteoblastic cells exhibited high angiogenic power as to endothelial cell proliferation. Our findings indicated that VEGF121 principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. The present study also demonstrated the differential expression of VEGF121 during osteoblastogenesis. The increase of VEGF in the early stage might be a useful marker of induction of bone formation due to human MSCs.  (+info)

Circulating proangiogenic cytokines and angiogenesis inhibitor endostatin in untreated patients with chronic lymphocytic leukemia. (8/368)

The serum concentration of two pro-angiogenic cytokines: basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF-beta1), and anti-angiogenic factor endostatin in the serum of 80 never treated B-cell chronic lymphocytic leukemia (CLL) patients and 27 healthy volunteers was measured using an enzyme linked immunosorbent assay. The serum levels of both bFGF and TGF-beta1 were found to be significantly higher in the CLL group (median 40.5 pg/ml and 38.6 ng/ml respectively) when compared to the control group (median 9.4 pg/ml and 18.9 ng/ml, respectively) (p<0.001). The levels of endostatin were not significantly different in CLL and control groups (median 12.3 ng/ml and 8.4 ng/ml, respectively) (p=0.09). In the group of CLL patients the level of bFGF was significantly higher in patients with progressive disease as compared with patients with stable disease (median 90.5 pg/ml and 40.5 pg/ml respectively) (p<0.001). Patients in Rai stage III and IV also had significantly higher levels of bFGF than patients in Rai stage 0-II (median 100.1 pg/ml and 29.3 pg/ml respectively) (p<0.001). The levels of both TGF-beta1 and endostatin were lower in patients in Rai stage III and IV (median 28.9 ng/ml and 9.1 ng/ml respectively) than in patients in Rai stage 0-II (42.8 ng/ml and 13.1 ng/ml respectively) (p<0.001 and p=0.002 respectively). The level of endostatin was also lower in the group of CLL patients with progressive disease (median 10.0 ng/ml) as compared to patients with stable disease (median 20.5 ng/ml) (p=0.008). In conclusion, the disturbance in the balance between pro- and anti-angiogenic factors may have an important influence on the course of CLL.  (+info)

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3-end of this gene results in three products of undetermined function.[2] ...
BAI2 antibody (brain-specific angiogenesis inhibitor 2) for IHC-P. Anti-BAI2 pAb (GTX71911) is tested in Human samples. 100% Ab-Assurance.
BAP3 was initially identified through interaction in a yeast two-hybrid system with the brain-specific angiogenesis inhibitor 1, a p53-target gene that encodes a seven-span transmembrane protein member of the secretin receptor family. BAP3 is predominantly expressed in the brain and possess high homology with Munc13 and synaptotagmin, suggesting that BAP3 may play a role in regulating neurotransmitter release. Recent experiments have shown that BAP3 is induced in certain tumors such as desmoplastic small round cell tumor. Ectopic expression of BAP3 in tumor cells dramatically enhances growth in low serum conditions and colony formation in soft agar, suggesting that the regulated exocytotic pathway may play a role in cancer cell proliferation. BAP3 is known to have two isoforms; this BAP3 antibody will recognize only isoform 2. Lower molecular weight bands may represent cleavage or degradation products. ...
This is the first report that Del-1 is expressed in adult animals in response to ischemia and that it plays an important role in adult angiogenesis. The protein encoded by Del-1 plays a critical role in embryonic vascular development. However, at the time of birth, the gene becomes quiescent, and Del-1 is no longer expressed in normal adult tissues.. In the embryo, Del-1 is expressed by endothelial progenitor cells and is secreted into the extracellular matrix.1 Del-1 supports adherence and migration of endothelial cells, mediated largely through the αvβ3 integrin receptor. Accumulating evidence indicates that angiogenesis requires signaling through both growth factor and integrin signaling pathways. Endothelial cells deprived of either influence will undergo programmed cell death.12 Indeed, in the chick CAM assay, antibodies directed against αvβ3 suppress Del-1-induced angiogenesis.13 A mutant form of Del-1, when the RGD motif has been altered (RGD→RAD), also disrupts angiogenesis in this ...
Product Pig Angiogenic factor with G patch and FHA domains 1(AGGF1) ELISA kit From B-Gene - A competitive ELISA for quantitative measurement of Porcine Angiogenic factor with G patch and FHA domains 1(AGGF1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUTION*1 vial 12. WASH SOLUTION (100 x)*1 vial 13. BALANCE SOLUTION*1 vial 14. INSTRUCTION*1
The energy requirements of the brain are large and immediate. The need to deliver adequate oxygen and glucose and to remove carbon dioxide specifies the vascular architecture. Taken as a whole, the...
Bai Yue is a medicine available in a number of countries worldwide. A list of US medications equivalent to Bai Yue is available on the Drugs.com website.
0005] One embodiment of the invention provides a method of detecting cancer or a predisposition to developing cancer in a subject. The method comprises determining an expression level of a cancer-associated polynucleotide, protein, or polypeptide selected from the group consisting of Titin; HBA1; Insulin-like growth factor 1 receptor (IGF1R); Isoform 3 of zonadhesin precursor; latent transforming growth factor beta binding protein 4 (LTBP4); ASXL1 (additional sex combs like 1); beta globin (HBB); BMP15-bone morphogenetic protein; TRIM49; DNAJ homolog subfamily B member 11 precursor; uncharacterized hematopoietic stem/progenitor cells protein MDS027; uncharacterized protein ALB; isoform 3 of sushi, nidogen and EGF-like domain-containing protein 1 precursor; isoform 2 of peripherin; mitochondrial 28S ribosomal protein S22; translation initiation factor EIF-2B subunit epsilon; estradiol 17-beta-dehydrogenase 1; XRCC6BP1; brain-specific angiogenesis inhibitor 1 precursor; isoform 2 of ring finger ...
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1 gene. The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. MAGI1 has been shown to interact with: ACCN3, ATN1, Actinin alpha 4, Beta-catenin, Brain-specific angiogenesis inhibitor 1, Calcium-activated potassium channel subunit alpha-1, FCHSD2, LRP2, and SYNPO. ENSG00000151276 GRCh38: Ensembl release 89: ENSG00000282956, ENSG00000151276 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000045095 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Shiratsuchi T, ...
The ultimate goal of this proposal is to understand the contribution of Vstat120 expressing oncolytic viruses on OV propagation, tumor biology and anti-tumor ef...
Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Sigma-Aldrich offers abstracts and full-text articles by [Maosheng Zhan, Yumiko Hori, Naoki Wada, Jun-Ichiro Ikeda, Yuuki Hata, Keigo Osuga, Eiichi Morii].
TY - JOUR. T1 - Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell-based spheroids in a 3D matrix. AU - Kim, Sook Kyoung. AU - Lee, Jaeyeon. AU - Song, Myeongjin. AU - Kim, Mirim. AU - Hwang, Soon Jung. AU - Jang, Hwanseok. AU - Park, Yongdoo. PY - 2015. Y1 - 2015. N2 - Combinations of angiogenic growth factors have been shown to have synergistic effects on angiogenesis and natural wound healing in various animal models. Each growth factor has unique roles during angiogenesis; vascular endothelial growth factor (VEGF) plays a key role during the initial step of angiogenesis, whereas PDGF functions in the maturation of blood vessels. We used a combination of three angiogenic growth factors to increase angiogenesis in vitro and in vivo. We chose VEGF as a basic factor and added platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) to induce angiogenesis in three in vitro and in vivo models: 3D ...
Anat Rec (Hoboken). 2013 Aug;296(8):1161-8. doi: 10.1002/ar.22676. Epub 2013 Jun 6. Comparative Study; Research Support, Non-U.S. Govt
Christensen, A C M and Haresign, W and Khalid, M (2014) Progesterone exposure of seasonally anoestrous ewes alters the expression of angiogenic growth factors in preovulatory follicles. Theriogenology, 81 (2). pp. 358-367. ...
Therapeutic angiogenesis remains a worthy but somewhat elusive clinical goal. Attempts to increase blood flow to ischemic tissue have included a variety of physical and biological approaches. A growing understanding of the cells and proteins involved in vessel sprouting and maturation led to a number of genetic approaches aimed at promoting angiogenesis in ischemic myocardium and skeletal muscle. In spite of several strategies undergoing testing in clinical trials, the delivery of vectors encoding for single growth factors has not yet shown clinical efficacy. In response to these challenges, a number of groups have aimed to provide multiple angiogenic factors for ischemic tissue. These approaches include gene transfer of transcription factors that regulate multiple angiogenic peptides (such as hypoxia inducible factor-1 ) or transplantation of cells capable of providing a regulated source of secreted growth factors and cytokines. A potential advantage of delivered cells is that they may also directly
Looking for online definition of angiogenic in the Medical Dictionary? angiogenic explanation free. What is angiogenic? Meaning of angiogenic medical term. What does angiogenic mean?
Adrenomedullin promotes formation of xenografted endometrial tumors by stimulation of autocrine growth and angiogenesis.: The angiogenic peptide adrenomedullin
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VG5Q functions as an angiogenic factor in promoting angiogenesis and suppression of VG5Q expression inhibits vessel formation. Angiogenic factors are…
Definition of angiogenic gene therapy in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is angiogenic gene therapy? Meaning of angiogenic gene therapy as a finance term. What does angiogenic gene therapy mean in finance?
TY - JOUR. T1 - Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. AU - Bosch-Marce, Marta. AU - Okuyama, Hiroaki. AU - Wesley, Jacob B.. AU - Sarkar, Kakali. AU - Kimura, Hideo. AU - Liu, Ye V.. AU - Zhang, Huafeng. AU - Strazza, Marianne. AU - Rey, Sergio. AU - Savino, Lindsey. AU - Zhou, Yi Fu. AU - McDonald, Karin R.. AU - Na, Youn. AU - Vandiver, Scott. AU - Rabi, Alireza. AU - Shaked, Yuval. AU - Kerbel, Robert. AU - LaVallee, Theresa. AU - Semenza, Gregg L.. PY - 2007/12/1. Y1 - 2007/12/1. N2 - Ischemia is a stimulus for production of angiogenic cytokines that activate local vascular cells and mobilize angiogenic cells to the circulation. These responses are impaired in elderly patients with peripheral arterial disease. Hypoxia-inducible factor (HIF)-1 mediates adaptive responses to ischemia, including production of angiogenic cytokines. In this study, we demonstrate that aging and HIF-1 loss-of-function ...
We have previously shown that intracoronary delivery of recombinant adenoviruses encoding angiogenic proteins that contain signal peptides (fibroblast growth factor-4 and fibroblast growth factor-5) ameliorate myocardial ischemia. In the present paper, we test the hypothesis that the presence of the signal peptide is an important element in the favorable effects that transgene expression has on regional flow and function in an animal model of myocardial ischemia. We performed intracoronary delivery of two different recombinant adenoviruses encoding a fibroblast growth factor-2 variant, one with a signal peptide, FGF-2LI(+sp), and one without a signal peptide, FGF-2LI(-sp). In a model of stress-induced myocardial ischemia, intracoronary injection of these recombinants resulted in mRNA and protein expression of the transferred gene. Two weeks after gene transfer, regional abnormalities in stress-induced function and blood flow were improved after delivery of FGF-2LI containing the signal peptide. ...
PRIMARY OBJECTIVES:. I. To evaluate the response rate of chemotherapy-refractory sarcomas to 20 mg per day of single-agent Ang(Angiotensin)-(1-7) or 10 mg per day of single-agent Ang-(1-7) if excessive toxicity is observed at the 20 mg dose.. II. To evaluate toxicities associated with single-agent Ang-(1-7) when given to patients with chemotherapy-refractory sarcomas.. SECONDARY OBJECTIVES:. I. To assess time to progression (TTP) and overall survival (OS) in patients treated with Ang-(1-7).. II. To evaluate accumulation of Ang-(1-7) after 21 days of continuous treatment and quantify changes in plasma levels of angiogenic peptides including placental growth factor (PlGF).. OUTLINE:. Patients receive therapeutic angiotensin-(1-7) subcutaneously (SC) once daily in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter. ...
Advanced St IIIB/IV NS-NSCLC p with ECOG 0-2 prospectively included and treated 1st-line with CP-Bev 6 cycles followed by Bev maintenance. Primary end-point: PFS; secondary end-points: OS, RR, toxicity. Ancillary study designed to investigate relationship between angiogenic mediators, response and outcomes. Ethical approval and informed consent for collecting peripheral blood samples and associated clinical data. Samples collected before treatment (basal) and at response evaluation (post). DNA obtained from leukocyte fraction. SNPs of angiogenic genes genotyped by PCR. Plasma levels of VEGFA and VEGFR2 determined by ELISA. Response RECIST.1 and toxicity CTCAEv.1. ...
We investigated whether the angiogenic profile, which is based on the local expression and systemic levels of angiogenic growth factors (VEGF, Ang-1, Ang-2, and the corresponding receptors), differs between rheumatoid arthritis (RA) and osteoarthritis (OA) patients. We determined the expression of VEGF, Ang-1, and Ang-2 together with its receptors (VEGFR-1/-2 ...
Sigma-Aldrich offers abstracts and full-text articles by [M C Ramello, J Tosello Boari, F P Canale, H A Mena, S Negrotto, B Gastman, A Gruppi, E V Acosta Rodríguez, C L Montes].
Code : 6027 Pin-Yin Name : Sang Bai Pi Chinese Name : 桑白皮 English Name : Mulberry Bark Pharmaceutical Name : Mori Cortex Capacity :100g ...
Klippel-Trenaunay syndrome is a birth (congenital) condition that affects the development of blood vessels, soft tissue and bones.
Klippel-Trenaunay syndrome is a birth (congenital) condition that affects the development of blood vessels, soft tissue and bones.
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Neuroinflammation and blood-brain barrier (BBB) disruption are two critical mechanisms of subarachnoid hemorrhage (SAH)-induced brain injury, which are closely related to patient prognosis. Recently, angiogenic factor with G-patch and FHA domain 1 (Aggf1) was shown to inhibit inflammatory effect and preserve vascular integrity in non-nervous system diseases. This study aimed to determine whether Aggf1 could attenuate neuroinflammation and preserve BBB integrity after experimental SAH, as well as the underlying mechanisms of its protective roles. Two hundred forty-nine male Sprague-Dawley rats were subjected to the endovascular perforation model of SAH. Recombinant human Aggf1 (rh-Aggf1) was administered intravenously via tail vein injection at 1 h after SAH induction. To investigate the underlying neuroprotection mechanism, Aggf1 small interfering RNA (Aggf1 siRNA) and PI3K-specific inhibitor LY294002 were administered through intracerebroventricular (i.c.v.) before SAH induction. SAH grade,
CASE SUMMARY A 5-month-old girl presented with recurrent seizures. The child was born at 36 weeks via C-section due to prenatal ultrasound abnormalities of t...
Introduction: We have previously shown that treatment with epidermacan a novel stem cell derived paracrine factor promoted angiogenesis in vitro accompanied with an increase in angiogenic miRNA expression. Here, we identified novel microRNAs regulated by epidermacan and validated their importance in modulating the epidermacan angiogenic effects in vitro and in vivo.. Methods and Results: Increased levels of pro-angiogenic miRNAs such as miR-10b, miR-21 and miR-424 were discovered in MicroRNA profiling of HUVEC cells treated with epidermacan and then confirmed by qRT-PCR. We also identified miR-874, a relatively unknown miRNA but for its role as a tumor suppressor. Investigation of the downstream microRNA/gene networks revealed that epidermacan regulated known angiogenic genes such as VEGFC, TBX1, HIF-1a and NRP1. Importantly, treatment with epidermacan decreased the levels of HoxD10, a known target of miR-10b in thrombin induced angiogenesis. Inhibition of miR-10b or miR-874 via anti-miR ...
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Background Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as...
Low expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity ...
Sierra-Honigmann, M.R., Nath, A.K., Murakami, C., Garcia-Cardena, G, Papapetropoulos, A., Sessa, W.C., Madge, L.A., Schechner, J.S., Schwabb, M.B., Polverini, P.J., and Flores-Riveros, J.R. (1998) Biological action of leptin as an angiogenic factor. Science 281:1683-1686 ...
Read about the journeys of our patients with Klippel-Trenaunay Syndrome from experts at Boston Childrens, ranked best Childrens Hospital by US News.
Learn about the programs and services for Klippel-Trenaunay Syndrome at Boston Childrens, ranked best Childrens Hospital by US News.
Timely regulated changes in oxygen partial pressure are important for placental formation. Disturbances could be responsible for pregnancy-related diseases like preeclampsia and intrauterine growth restriction. We aimed to (i) determine the effect of oxygen partial pressure on cytotrophoblast differentiation; (ii) measure mRNA expression and protein secretion from genes associated with placental angiogenesis; and (iii) determine the reversibility of these effects at different oxygen partial pressures. Term cytotrophoblasts were incubated at 21% and 2.5% O2 for 96 hr, or were switched between the two oxygen concentrations after 48 hr. Real-time PCR and enzyme-linked immunosorbent assays (ELISAs) were used to evaluate cell fusion and differentiation, measuring transcript levels for those genes involved in cell fusion and placental angiogenesis, including VEGF, PlGF, VEGFR1, sVEGFR1, sENG, INHA, and GCM1. Cytotrophoblasts underwent fusion and differentiation in 2.5% O2 . PlGF expression was ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Publishers, "Placental Growth Factor (PIGF) Blockers-Pipeline Insights, 2016″, report provides in depth insights on the pipeline drugs and their development activities around the Placental Growth Factor (PIGF) Blockers. The Publishers Report covers the product profiles in various stages of development including Discovery, Pre-clinical, IND, Phase I, Phase II, Phase III and Preregistration. Report covers the product clinical trials information and other development activities including technology, licensing, collaborations, acquisitions, fundings, patent and USFDA & EMA designations details. Publishers Report also provides detailed information on the discontinued and dormant drugs that have gone inactive over the years for Placental Growth Factor (PIGF) Blockers. Publishers Report also assesses the Placental Growth Factor (PIGF) Blockers therapeutics by Monotherapy, Combination products, Molecule type and ...
Angiogenesis is the formation of new blood vessels from existing vasculature. Vascular Endothelial Growth Factor (VEGF), a known angiogenic protein, stimulates endothelial cell proliferation and migration via interactions with its receptors, KDR and Flt-1. A secreted form of Flt-1 (sFlt-1), derived from alternatively-spliced RNA, can inhibit actions of VEGF in vivo. It has been suggested that alterations in sFlt-1 expression could significantly change the angiogenic VEGF activity. This project focuses on characterizing intronic elements that regulate Flt-1 mRNA splicing. A "wild-type" construct (pFIN13), containing the first 13 exons, intron 13 and exons 14-30 of mouse Flt-1, was shown to produce both forms of Flt-1 mRNA after transfection into HEK293 cells. To gauge the strength of the native splicing signals in intron 13 of Flt-1, a series of point mutations were made in the polypyrimidine tract using pFIN13. After transient transfection, the levels of Flt-1 and sFlt-1 protein and mRNA were ...
Endometriosis is a chronic, inflammatory disease characterized by the growth of endometrial tissue in aberrant locations outside the uterus. Neoangiogenesis or establishment of new blood supply is one of the fundamental requirements of endometriotic lesion survival in the peritoneal cavity. IL-17A is emerging as a potent angiogenic and proinflammatory cytokine involved in the pathophysiology of several chronic inflammatory diseases such as rheumatoid arthritis and psoriasis. However, sparse information is available in the context of endometriosis. In this study, we demonstrate the potential importance of IL-17A in the pathogenesis and pathophysiology of endometriosis. The data show a differential expression of IL-17A in human ectopic endometriotic lesions and matched eutopic endometrium from women with endometriosis. Importantly, surgical removal of lesions resulted in significantly reduced plasma IL-17A concentrations. Immunohistochemistry revealed localization of IL-17A primarily in the stroma ...
Comment Bubble I have a dream! Im calling it the International K-T House & Mentor Program*. So many parents first learn of Klippel-Trenaunay Syndrome when their child is born with it. Those moments are often frantic moments, particularly for parents whose children are born looking very different from the picture they had in mind. Making this experience…
Cancer Therapy Advisor provides pediatricians with the latest information to correctly diagnose the latest child medical disorder conditions, recommend procedures and guides. Visit often for updates and new information.
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mair un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ANGPT2. ...
Angiogenesis is a multicellular morphogenesis process that expands vascular networks in tissue. Various biological components concertedly contribute to angiogenic morphogenesis. The most important cellular component is endothelial cells, which we use to reconstruct 3D angiogenic process in a extracellular matrix in response to angiogenic growth factors. In addition, perivascular pericytes, blood flow and extravascular tissue importantly serve as (sub)components that allow constructing more sophisticated vascular networks. However, a mechanistic understanding of how the individual components contribute to various angiogenic processes is largely missing. In this seminar, I will introduce a reconstitution angiogenesis assay system with a microfluidic device that allows dissecting the phenomenon in a bottom-up way by adding individual components to the essential one. I will discuss the roles of pericyte and intraluminal pressure on angiogenic morphogenesis based on recent unpublished data obtained ...
Nakajima, K-Ichi.; Kanno, Y.; Nakamura, M.; Gao, X-Dong.; Kawamura, A.; Itoh, F.; Ishisaki, A., 2011: Bovine milk lactoferrin induces synthesis of the angiogenic factors VEGF and FGF2 in osteoblasts via the p44/p42 MAP kinase pathway
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... is protein that in humans is encoded by the TNFSF15 gene. VEGI is an anti-angiogenic protein. It belongs to tumor necrosis ... Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) ... This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this ... It is the sole known ligand for death receptor 3, and it can also be recognized by decoy receptor 3. The protein encoded by ...
Circulating angiogenic proteins trisomy 12 Am J Obstet Gynecol. 2006 Jan:194(1):239-45 Sachs BP, A Woman with Fetal Loss - ... Circulating Angiogenic Factors and the Risk of Preeclampsia. NEJM 2004; 350:672-83 Levine RJ, Thadhani R, Qian C, Lam C, Lim KH ... a novel circulating anti-angiogenic factor in preeclampsia. N Engl J Med 2006;355:992-1005 Nielsen P, Goldman M, Mann S, ...
"The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma". J. Leukoc. Biol. 67 (1): 53-62. PMC 2669312 . PMID ... neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is ... for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins ...
"HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Bonaldo MF, Lennon G, ... Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein encoded by this gene is a transmembrane (type ... The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and ... Indatuximab ravtansine targets this protein. It is a useful marker for plasma cells, but only if the cells tested are already ...
"HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Kojima T, Katsumi A, ... The protein is found as a homodimer and is a member of the syndecan proteoglycan family. Syndecan-4 interacts with ... Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has ... Syndecan-4 activates protein kinase C (PKC), an enzyme involved in signal transduction. The variable domain of syndecan-4 could ...
These gene products may include proteins such as glycolytic enzymes and angiogenic growth factors. In normoxia, HIF alpha ... 1996). "SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscle". Lab. Invest. 74 ( ... Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2), or prolyl hydroxylase domain-containing protein 2 (PHD2), is an enzyme ... 2006). "Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia- ...
The angiogenic switch downregulates angiogenesis suppressor proteins, such as thrombospondin, angiostatin, endostatin and ... GSCs are easily identified through histological staining against vasa protein (to identify germ cells) and 1B1 protein (to ... Angiogenesis induced by hypoxic conditions is called an "Angiogenic switch". HIF-1 promotes expression of several angiogenic ... But there is evidence that the expression of angiogenic agens by cancer cells can also be HIF-1 independent. It seems that ...
In contrast, pro-angiogenic protein therapy uses well-defined, precisely structured proteins, with previously defined optimal ... which angiogenic research began with, and pro-angiogenic therapies. Whereas anti-angiogenic therapies are being employed to ... Until 2007, three human clinical trials have been successfully completed with FGF-1, in which the angiogenic protein was ... Chemical stimulation of angiogenesis is performed by various angiogenic proteins, including several growth factors. The ...
1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Chernousov MA, ... Hakansson S, Jacobs A, Caffrey M (2001). "Heparin binding by the HIV-1 tat protein transduction domain". Protein Sci. 10 (10): ... Syndecan-3 is a protein that in humans is encoded by the SDC3 gene. GRCh38: Ensembl release 89: ENSG00000162512 - Ensembl, May ... "Entrez Gene: SDC3 syndecan 3". Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency ...
... cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV. These proteins, ... is a novel angiogenic regulator of the CCN protein family". The Journal of Biological Chemistry. 278 (26): 24200-8. doi:10.1074 ... The human NOV protein contains 357 amino acids with an N-terminal secretory signal peptide followed by four structurally ... Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B (Feb 1999). "The C-terminal domain of the regulatory protein NOVH ...
... and anti-angiogenic effects. In biomarker studies, the protein has been found to have potential prognostic and diagnostic value ... "Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes". The ... The HRG protein is produced in the liver, and it could also be synthesized by monocytes, macrophages, and megakaryocytes. It ... Two of the protein's effects, the inhibition of fibrinolysis and the reduced inhibition of coagulation, indicate a potential ...
"Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and ... The protein content of a single exosome, given certain assumptions of protein size and configuration, and packing parameters, ... Exosomes contain RNA, proteins, lipids and metabolites that is reflective of the cell type of origin. As exosomes contain ... Although the exosomal protein composition varies with the cell and tissue of origin, most exosomes contain an evolutionarily- ...
"Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity". The Journal ... This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to ... "Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell ... the remaining anti-angiogenic domains have been shown to have decreased anti-angiogenic activity at low concentrations where ...
This protection appears to be due to the elevated levels of endostatin, an anti-angiogenic protein, derived from collagen XVIII ... An experimental study suggests that the pericyte death is caused by blood glucose persistently activating protein kinase C and ... mitogen-activated protein kinase (MAPK), which through a series of intermediates inhibits signaling through platelet-derived ...
... an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits ... Silmitasertib (INN), codenamed CX-4945, is a small-molecule inhibitor of protein kinase CK2 (casein kinase II), a ... the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer". Journal of Medicinal Chemistry. 54 (2): ... constitutively active serine/threonine-specific protein kinase that is overexpressed in several types of tumors. Silmitasertib ...
... an angiogenic protein, at 2.0 A resolution". The Journal of Biological Chemistry. 276 (15): 12153-61. doi:10.1074/jbc. ... Placental growth factor is a protein that in humans is encoded by the PGF gene. Placental growth factor (PGF) is a member of ... Placental growth factor (PGF) is a protein-coding gene and a member of the vascular endothelial growth factor (VEGF) family. ... Roberts-Clark DJ, Smith AJ (November 2000). "Angiogenic growth factors in human dentine matrix". Archives of Oral Biology. 45 ( ...
"Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1". ... This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins belong to the 2-oxoglutarate (2OG)- ... They are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative ... "Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and ...
These effects are mediated by interacting and interfering with various angiogenic related proteins such as integrins and serine ... "Structure-function analysis of the ADAM family of diintegrin-like and metalloproteinase-containing proteins". J. Protein Chem. ... Native proteins which contain such domains with regulatory activity are normally inactive, most likely because they are cryptic ... Monocytes produce a variety of pro-angiogenic factors. There is also a population of CD34 positive cells that can express ...
Nam, J. O.; Jung, M. Y.; Thapa, N.; Lee, B. H.; Park, R. W.; Kim, I. S. (2008). "T-CAM, a fastatin-FIII 9-10 fusion protein, ... potently enhances anti-angiogenic and anti-tumor activity αvβ3 and α5β1 integrins". Experimental & Molecular Medicine. 40 (2): ... Nam, J. -O.; Son, H. -N.; Jun, E.; Cha, K.; Lee, B. -H.; Park, R. -W.; Kim, I. -S. (2012). "FAS1 Domain Protein Inhibits ... Thapa, N.; Lee, B. H.; Kim, I. S. (2007). "TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β". The ...
6,0 6,1 6,2 Bargahi A, Rabbani-Chadegani A (Februar 2008). »Angiogenic inhibitor protein fractions derived from shark cartilage ... A novel polypeptide from shark cartilage with potent anti-angiogenic activity«. Cancer Biology & Therapy 6 (5): 775-780. PMID ... Identification of low-molecular-weight protein (SCP1) from shark cartilage with anti-angiogenesis activity and sequence ...
Angiogenic proteins such as vascular endothelial growth factor (VEGF) and placental growth factor (PIGF) and anti-angiogenic ... sFlt-1 is an anti-angiogenic protein that antagonizes vascular endothelial growth factor (VEGF) and placental growth factor ( ... Proteinuria ≥ 0.3 grams (300 mg) or more of protein in a 24-hour urine sample or a SPOT urinary protein to creatinine ratio ≥ ... Implicit in this generalized endothelial dysfunction may be an imbalance of angiogenic and anti-angiogenic factors. Both ...
... is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functions. Found in ... The PEDF protein is a secreted protein of roughly 50kDa size and 418 amino acids in length. The N-terminus contains a leader ... They isolated proteins unique to RPE cells and tested the individual proteins for neurotrophic function, meaning promoting a ... This discovery demonstrated that PEDF has an asymmetrical charge distribution across the whole protein. One side of the protein ...
2003). "The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through ... Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. It belongs to the ... Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to ... 1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc ...
1997). "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer". Nat. Med. 3 (10): 1137-40. doi: ... 2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated ... Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. FGFBP1, or HBP17, binds ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ...
... splice site determines whether the proteins are pro-angiogenic (proximal splice site, expressed during angiogenesis) or anti- ... Zan L, Zhang X, Xi Y, Wu H, Song Y, Teng G, Li H, Qi J, Wang J (2014). "Src regulates angiogenic factors and vascular ... A number of VEGF-related proteins encoded by viruses (VEGF-E) and in the venom of some snakes (VEGF-F) have also been ... The overexpression of VEGF-A may be an early step in the process of metastasis, a step that is involved in the "angiogenic" ...
Gabriele Bergers, Laura E. Benjamin: Angiogenesis: Tumorigenesis and the angiogenic switch. (PDF; 2,4 MB). In: Nature Reviews ... nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis. In: Cancer Cell. Band 1, Nr. 2, März 2002, S. ...
Vascular endothelial growth factor (VEGF) is definitely 1 of the many essential angiogenic growth factors for tumor ... Similar launching of protein on the skin gels was validated by re-probing the blots with an antibody particular for the house ... Similar quantities of proteins fractions or immunoprecipitates of lysates with indicated antibodies had been solved over SDS- ... Protein had been recognized with major antibodies adopted by HRP-conjugated supplementary antibodies. ...
a VEGF165 protein extraction. Lane 1-5 corresponds respectively to total protein extracted from conditions M1 Alumina treatment ... To further characterize the pro-angiogenic proprieties of recombinant VEGF165 we performed ex vivo angiogenesis using Chick ... but the optimization of the protein extraction method remains a major challenge for a high percentage of the produced protein. ... With the fact that 30% of proteins from E.coli itself cannot be expressed in soluble form, it is meant that the main ...
... M. J. Koss, M. Pfister, and F. H. ... M. J. Koss, M. Pfister, and F. H. Koch, "Inflammatory and Angiogenic Protein Detection in the Human Vitreous: Cytometric Bead ...
Developmental Endothelial Locus-1 (Del-1), a Novel Angiogenic Protein. Its Role in Ischemia. Hoai-Ky V. Ho, James J. Jang, ... Mutation of the RGD to RAD sequence reduces its angiogenic effect in the CAM assay to one third of that of the native protein. ... Developmental Endothelial Locus-1 (Del-1), a Novel Angiogenic Protein. Hoai-Ky V. Ho, James J. Jang, Shuichiro Kaji, Gary ... Developmental Endothelial Locus-1 (Del-1), a Novel Angiogenic Protein. Hoai-Ky V. Ho, James J. Jang, Shuichiro Kaji, Gary ...
A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.. Folkman J1, ... The sequestration of angiogenic endothelial mitogens in the basement membrane may be a general mechanism for regulating their ... The basement membranes of bovine cornea are found to contain an angiogenic endothelial cell mitogen, basic fibroblast growth ... These findings indicate that basement membranes of the cornea may serve as physiologic storage depots for an angiogenic ...
Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery (RAAPID-II). The safety and scientific validity of this ... 32 weeks in gestation in a woman with previously normal BP and proteinuria 0.3 grams in a 24-hour specimen or urine protein/ ...
Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery (RAAPID-II). This study has been completed. ...
Multiple pregnancies are thought to be associated with a high incidence of perinatal complications such as preterm labor, preeclampsia and low birth weight. But the true mechanisms of these obstetric complications are still uncertain. The components
Angiogenic protein expression in advanced epithelial ovarian cancer.. D P Barton, A Cai, K Wendt, M Young, A Gamero and S De ... Angiogenic protein expression in advanced epithelial ovarian cancer.. D P Barton, A Cai, K Wendt, M Young, A Gamero and S De ... Angiogenic protein expression in advanced epithelial ovarian cancer.. D P Barton, A Cai, K Wendt, M Young, A Gamero and S De ... Angiogenic protein expression in advanced epithelial ovarian cancer. Message Subject (Your Name) has forwarded a page to you ...
Protein. Similar proteins. Species. Score. Length. Source. Q8N302. Angiogenic factor with G patch and FHA domains 1, isoform ... Protein. Similar proteins. Species. Score. Length. Source. Q8N302. Angiogenic factor with G patch and FHA domains 1, isoform ... Protein. Similar proteins. Species. Score. Length. Source. Q8N302. Angiogenic factor with G patch and FHA domains 1, isoform ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ...
... protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions ... 3-1. aMTD/SD-Fused SOC53 Recombinant Proteins Are Cell-Permeable To examine protein uptake, SOCS3 recombinant proteins were ... Development of Protein-Based Biotherapeutics That Penetrates Cell-Membrane and Induces Anti-Angiogenic Effect - Improved Cell- ... In the present art, iCP-SOCS3 proteins have been tested for use as anti-angiogenic agents. Since SOCS3 is known to be an ...
Plasmalemma Vesicle-Associated Protein Promotes Angiogenesis by Stimulation of the Endothelial Production of Pro-Angiogenic ... Plasmalemma Vesicle-Associated Protein Promotes Angiogenesis by Stimulation of the Endothelial Production of Pro-Angiogenic ... Plasmalemma Vesicle-Associated Protein Promotes Angiogenesis by Stimulation of the Endothelial Production of Pro-Angiogenic ... Plasmalemma Vesicle-Associated Protein Promotes Angiogenesis by Stimulation of the Endothelial Production of Pro-Angiogenic ...
The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway. Yugang Wang, ... The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway ... The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway ... The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway ...
Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity. SS Tolsma, OV ... Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity ... The definition of short peptides from each of these domains that are able to block the angiogenic process may be of use in ... The majority of the anti-angiogenic activity of TSP1 resides in the central 70-kD stalk region which alone could block ...
In this study, the anti-angiogenic features of one of these genes (angiopoietin like protein 7; angptl7) were examined in vitro ... Angiopoietin like protein 7 is a novel anti-angiogenic molecule expressed in cornea ... Angiopoietin like protein 7 is a novel anti-angiogenic molecule expressed in cornea ... Angiopoietin like protein 7 is a novel anti-angiogenic molecule expressed in cornea. Invest. Ophthalmol. Vis. Sci. 2014;55(13): ...
An in Vivo Function for the Transforming Myc Protein: Elicitation of the Angiogenic Phenotype. 1 Cam V. Ngo, Michael Gee, Nasim ... Genomic targets of the human c-Myc protein. Genes & Dev., May 1, 2003; 17(9): 1115 - 1129. [Abstract] [Full Text] [PDF] ... These data suggest that Myc is fully competent to trigger the angiogenic switch in vivo and that secondary events may not be ... The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes & Dev., September 15, 2006; 20(18): 2527 ...
G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion. ... Akt-cAMP response element binding protein (CREB) pathway, which led to decreased production of the pro-angiogenic mediator ... G-protein-coupled receptor 81 (GPR81) functions as a receptor for lactate and plays an important role in the regulation of anti ...
Plasma angiogenic proteins were evaluated as potential PD biomarkers of response to lenvatinib in a dose-escalation phase 1 ... PD biomarker changes observed in plasma angiogenic proteins are correlated with lenvatinib-induced tumor shrinkage and AEs. Our ... Blood samples for plasma proteins were collected on days 1 (baseline), 8, and 15 of cycle 1, and days 1, 8, and 15 of cycle 2. ... findings warrant further assessment of plasma proteins associated with angiogenesis as potential biomarkers of lenvatinib ...
Our findings denote for the first time distinct angiogenic subtypes of human glioblastoma which may prove relevant for anti- ... patterns in primary glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins. ... No data exist on angiogenic patterns and their prognostic impact in human glioblastoma. Such data are relevant for translation ... Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: ...
Smith, J. R., David, L., Appukuttan, B., & Wilmarth, P. (Accepted/In press). Angiogenic and Immunologic Proteins Identified by ... Smith, JR, David, L, Appukuttan, B & Wilmarth, P 2018, Angiogenic and Immunologic Proteins Identified by Deep Proteomic ... Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial ... Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial ...
Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Porcine Cyr61 (Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit » Porcine Cyr61 (Cysteine Rich Protein, Angiogenic ... Porcine Cyr61 (Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit. Porcine Cyr61 (Cysteine Rich Protein, Angiogenic ... Porcine Cyr61 (Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit. Porcine Cyr61 (Cysteine Rich Protein, Angiogenic ...
The pro-angiogenic property may contribute to the beneficial effects reported after treatment of chronic ulcers with the novel ... Porcine serum albumin was used as control for unspecific protein effects. The plates were incubated at 37°C and sprouting was ... This result is comparable to the positive control, fibronectin, an ECM protein involved in all phases of tissue repair. Taken ... Amelogenin is an extracellular matrix protein that has been reported to promote formation of granulation tissue and repair of ...
Shear-Sensitive Angiogenic Genes and Proteins. To identify the genes and the secreted proteins that are responsible for shear- ... Angiopoietin-2 (Ang2), a known angiogenic protein, was found to be downregulated by LS both in cultured ECs and mouse aortas. ... To examine this hypothesis, we carried out gene array and protein array studies specific for angiogenic factors and cytokines, ... mediated tubule formation and migration, we performed a gene array containing 128 human angiogenic genes and a protein array of ...
3.2 Momordica charantia extracts increase the phosphorylation of angiogenic signaling protein ERK1/2. Because the activation of ... This hypothesis was verified based on the induced phosphorylation of angiogenic signaling protein ERK1/2 and on tube formation ... The protein concentration in each sample was determined using a Bio-Rad protein assay. The volume of each sample containing 20 ... Thus, MC extracts exert direct pro-angiogenic signaling mediated via RAGE to overcome the anti-angiogenic effects of high BSA- ...
Angiogenic Proteins. Grant support. *2T32HL007950/HL/NHLBI NIH HHS/United States. *5K08HL093362/HL/NHLBI NIH HHS/United States ...
  • Activation of cell survival pathways such as phosphoinositide-3-kinase/AKT/IKK or RAS/mitogen-activated protein kinase phosphorylates FOXOs at different sites which regulate FOXOs nuclear localization or degradation. (hindawi.com)
  • Mitogen-activated protein kinase (MAPK) pathway antagonists induce profound clinical responses in advanced cutaneous melanoma, but complete remissions are frustrated by the development of acquired resistance. (rupress.org)
  • To examine this hypothesis, we carried out gene array and protein array studies specific for angiogenic factors and cytokines, respectively. (ahajournals.org)
  • Together these findings illustrate how the morphoregulatory protein, HOXA3 can facilitate tissue remodeling via coordinated changes in both epithelial and endothelial cell gene expression and behavior in adult tissues during wound repair. (biomedsearch.com)
  • Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene. (wikipedia.org)
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (wikipedia.org)
  • Here we explore a novel approach to neurotrophic factor-based therapy by engineering zinc finger protein transcription factors (ZFP TFs) that activate the expression of the endogenous glial cell line-derived neurotrophic factor (GDNF) gene. (jneurosci.org)
  • First, how MDA-7 protein is regulated as tumors develop from benign moles to the full-blown skin cancer known as melanoma and secondly, how over-expression of the mda-7 gene will affect melanoma cancer cell growth. (bio-medicine.org)
  • The therapeutic application of virus or proteins (angiogenic gene and protein therapies) as well as of stem and progenitor cells (cell-based therapies) have emerged as viable options to target particularly critical limb ischaemia in refractory cases. (escardio.org)
  • The definition of short peptides from each of these domains that are able to block the angiogenic process may be of use in designing targeted inhibitors of the pathological neovascularization that underlies many diseases. (rupress.org)
  • Amino Acids, Peptides and Proteins (D12): 246 new descriptors were added. (nih.gov)
  • 1990). To determine which of the structural motifs present in the 180-kD TSP1 polypeptide mediate the anti-angiogenic activity, a series of protease-generated fragments were tested using several in vitro and in vivo assays that reflect angiogenic activity. (rupress.org)
  • Results: Human retinal and/or choroidal vascular endothelial cells expressed 5042 nonredundant proteins. (elsevier.com)
  • Smith, JR , David, L , Appukuttan, B & Wilmarth, P 2018, ' Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs ' American Journal of Ophthalmology . (elsevier.com)
  • Furthermore, using TaqMan Low-density Arrays we identified key pro-angiogenic genes induced by CRP among them were vascular endothelial cell growth factor receptor-2 (VEGFR2/KDR), platelet-derived growth factor (PDGF-BB), notch family transcription factors (Notch1 and Notch3), cysteine-rich angiogenic inducer 61 (CYR61/CCN1) and inhibitor of DNA binding/differentiation-1 (ID1). (biomedcentral.com)
  • Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension. (yale.edu)
  • These findings indicate that basement membranes of the cornea may serve as physiologic storage depots for an angiogenic molecule. (nih.gov)
  • In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. (freepatentsonline.com)
  • The anti-angiogenic and anti-tumoral activity of molecule like fastatin could be improved by fusing it with integrin-recognizing cell adhesion domain from other distinct proteins. (bvsalud.org)
  • Among a variety of AGE receptor or AGE-binding proteins that have been described, the receptor for AGEs (RAGE) is probably the best-characterized molecule. (diabetesjournals.org)
  • Ligation of RAGE in endothelial cells activates the transcription factor nuclear factor-κB (NF-κB), subsequently leading to increased expression of proatherogenic mediators, such as monocyte chemoattractant protein-1 or vascular cell adhesion molecule-1 ( 11 , 12 ). (diabetesjournals.org)
  • Angiostatic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Angiostatic Proteins" by people in Harvard Catalyst Profiles by year, and whether "Angiostatic Proteins" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Angiostatic Proteins" by people in Profiles. (harvard.edu)
  • rmB7.2-IgG is a fusion protein of the extracellular domain of B7.2, and the hinge and constant domains of murine IgG2a. (aacrjournals.org)
  • However, systemic protein delivery in vivo has been proven difficult due to poor tissue penetration and rapid clearance. (freepatentsonline.com)
  • Our findings suggest that the changes previously observed in maternal serum hormones and angiogenic proteins level after anti-hypertensive treatment in PE could be due to a systemic effect of the drugs on maternal blood pressure and circulation rather than a direct effect of these drugs on placental biosynthesis and/or secretion. (qxmd.com)
  • Previously, recombinant proteins consisting of suppressor of cytokine signaling 3 (SOSC3) fused to the fibroblast growth factor (FGF) 4-derived MTM were developed to inhibit inflammation and apoptosis. (freepatentsonline.com)
  • Furthermore, solubilization domains (SDs) have been incorporated into the aMTD-fused SOCS3 recombinant proteins to enhance solubility with corresponding increases in protein yield and cell-/tissue-permeability. (freepatentsonline.com)
  • Previously developed SOCS3 recombinant proteins fused to MTM were only tested or used as anti-inflammatory agents to treat acute liver injury. (freepatentsonline.com)
  • In a previous study using protein microarrays, we have identified regulation of potentially proangiogenic proteins associated with haemorrhagic vessels in unstable plaques among them c-Jun N-terminal kinase (JNK) and c-src [ 10 ]. (biomedcentral.com)
  • 2004) describing the dynamics of tumour, angiogenic proteins and effective vessels density. (aimsciences.org)
  • However, this SOCS3 fusion proteins expressed in bacteria cells were hard to be purified in soluble form. (freepatentsonline.com)
  • A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. (cancer.gov)
  • MC extracts or low concentrations of bovine serum albumin-derived AGEs (BSA-AGEs) stimulated proliferation, migration (using wound-healing assay) and tube formation (using Matrigel™-embedded 3D culture) of bovine aortic endothelial cells (BAEC) together with increases in the phosphorylation of extracellular signal-regulated kinase (ERK)1/2, the key angiogenic signaling cytoplasmic protein. (rsc.org)
  • Western blotting showed that CRP increased activation of early response kinase-1/2 (ERK1/2), a key protein involved in EC mitogenesis. (biomedcentral.com)
  • The protein kinase ATM is a sensor for reactive oxygen species. (sciencemag.org)
  • 2018. SPEN protein expression and interactions with chromatin in mouse testicular cells. (uib.no)
  • Publication date: 5 May 2018 Source:International Journal of Pharmaceutics, Volume 542, Issues 1-2 Author(s): Dae Gon Lim, Racelly Ena Prim, Eunah Kang, Seong Hoon Jeong The self-organizing complexes with hyaluronic acid (HA) and polydopamine (PDA), an adhesion mediator via hydrogen bonding, were investigated for use as protein drug carriers. (medworm.com)
  • The majority of the anti-angiogenic activity of TSP1 resides in the central 70-kD stalk region which alone could block neovascularization induced by bFGF in the rat cornea in vivo and inhibit both migration in a modified Boyden chamber and [3H]thymidine incorporation stimulated by bFGF in cultured capillary endothelial cells. (rupress.org)
  • Currently we know of dozens of proteins that induce or inhibit angiogensis through similar mechanisms. (ewg.org)
  • The basement membranes of bovine cornea are found to contain an angiogenic endothelial cell mitogen, basic fibroblast growth factor (FGF), as determined by heparin-affinity chromatography, immunoblotting, immunofluorescence, and stimulation of capillary endothelial cell proliferation. (nih.gov)
  • By compiling the drug information in two drug databases DrugBank and PharmGKB, we predict FDA-approved drugs whose targets are the proteins annotated as anti-angiogenic and pro-inflammatory, respectively. (frontiersin.org)
  • According to Ganem, early studies of Kaposi's sarcoma (KS) indicated that the abnormal growth of infected cells required the overproduction of cytokines - immune system proteins that trigger the cell's inflammatory response. (scienceblog.com)
  • 2019. Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy. (uib.no)
  • 2016. Expression of Heat Shock Protein 27 in melanoma metastases is associated with overall response to bevacizumab monotherapy: Analyses of predictive markers in a clinical phase II study. (uib.no)
  • 2017. Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma. (uib.no)
  • The over-production of cytokines resulting from kaposin B's binding to MK2 creates inflammation that in turn activates the regulatory protein p38. (scienceblog.com)
  • The IP receptor is coupled with Gs proteins and activates adenylate cyclase, leading to increased cyclic adenosine monophosphate levels in the target cells, which explains most of the biological effects. (ersjournals.com)
  • Upon subcutaneous administration, abaloparatide acts similar to PTHrP and targets, binds to and activates parathyroid hormone 1 (PTH1) receptor (PTH1R), a G protein-coupled receptor (GPCR) expressed in osteoblasts and bone stromal cells. (cancer.gov)
  • Thrombospondin-1 (TSP1) is a large modular matrix protein containing three identical disulfide-linked 180-kD chains that inhibits neovascularization in vivo (Good et al. (rupress.org)
  • HIF is a transcription factor, initiating the production of other proteins required to mediate the effects of hypoxia. (ewg.org)