Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It may play an important role in the development of branched CAPILLARIES during EMBRYOGENESIS.
Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.
The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.
An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.
Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
Degradation or wasting of the PERIODONTIUM tissues that may involve the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, or the PERIODONTAL LIGAMENT.
A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.
The level of governmental organization and function at the national or country-wide level.
The complex of political institutions, laws, and customs through which the function of governing is carried out in a specific political unit.
Exercise of governmental authority to control conduct.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A cell line derived from cultured tumor cells.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Organic compounds which contain selenium as an integral part of the molecule.
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Diagnostic tests conducted in order to measure the increment of active DENTAL CARIES over a period of time.
The state of failure to initiate and complete the process of growth, reproduction, or gemination of otherwise normal plants or vegetative structures thereof.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
The internal resistance of a material to moving some parts of it parallel to a fixed plane, in contrast to stretching (TENSILE STRENGTH) or compression (COMPRESSIVE STRENGTH). Ionic crystals are brittle because, when subjected to shear, ions of the same charge are brought next to each other, which causes repulsion.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
A family of intercellular signaling proteins that play and important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.
Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.
Pyrazolopyrimidine ribonucleosides isolated from Nocardia interforma. They are antineoplastic antibiotics with cytostatic properties.
The family Erinaceidae, in the order INSECTIVORA. Most are true hedgehogs possessing a coat of spines and a very short tail. Those members of the family found in Southeast Asia (moonrats or gymnures) have normal body hair and a long tail.

Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. (1/368)

Angiogenesis is required for the growth and progression of malignancies. Recent studies have demonstrated that genetic alterations may accompany acquisition of the angiogenic phenotype. The tumor suppressor gene p53 is most frequently mutated in human cancers and is also known to be a transcriptional regulator of a variety of genes. Here, we investigated the antiangiogenic effect of the wild-type p53 (wt-p53) gene transfer on a human non-small cell lung cancer cell line. Mutant p53-expressing H226Br non-small cell lung cancer cells were transduced with the wt-p53 gene using a recombinant adenoviral vector (Ad5CMVp53) and applied to semiquantitative reverse transcription-PCRs for the detection of altered mRNA expression of angiogenic and/or antiangiogenic factors. In vivo neovascularization assay of Ad5CMVp53-infected cells was then performed using a membrane-diffusion chamber system s.c. transplanted in nu/nu mice. We also evaluated the effect of Ad5CMVp53-infected H226Br cells on nontransduced tumor cells in vivo by s.c. inoculating mixture of cells into nu/nu mice. Ad5CMVp53 infection markedly inhibited the expression of an angiogenic factor, vascular endothelial growth factor, and increased the expression of a novel antiangiogenic factor, brain-specific angiogenesis inhibitor 1, resulting in reduced neovascularization in vivo. Mixing experiments showed that tumor cells transduced with the wt-p53 gene inhibited the in vivo tumor growth of adjacent nontransduced cells. Our data suggest that a recombinant adenovirus expressing the wt-p53 gene is antiangiogenic, which may explain, in part, the mechanism of the bystander effect induced by the wt-p53 gene transfer on adjacent tumor cells.  (+info)

Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: differential effect on proliferating endothelial cells. (2/368)

Vascular endothelial growth factor (VEGF) plays an important role in tumour angiogenesis. VEGF binds to tyrosine kinase receptors, which are expressed almost exclusively on tumour endothelium. Therefore, VEGF can be used to target toxin molecules to tumour vessels for anti-angiogenic therapy. However, recent evidence suggests that VEGF can also bind in an isoform-specific fashion to a newly identified neuropilin-1 (NP-1) receptor. NP-1 is widely expressed in normal tissue and presents a potential target for unwanted toxicity. As a consequence, we investigated whether the VEGF121 isoform, which lacks the NP-1 binding domain, could be used to target toxin polypeptides to tumour vasculature. Treatment of endothelial cells with a VEGF121-diphtheria toxin (DT385) conjugate selectively inhibited proliferating endothelial cells, whereas confluent cultures were completely resistant to the construct. In addition, VEGF121-DT385 conjugate treatment completely prevented tumour cell induced angiogenesis in vivo. Most importantly, the conjugate inhibited tumour growth in athymic mice and induced tumour-specific vascular damage. There was also no apparent toxicity associated with the treatment. Our results suggest that proliferating endothelial cells are highly sensitive to VEGF121-toxin conjugates and that the binding to NP-1 receptors is not necessary for efficient inhibition of tumour growth.  (+info)

Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer. (3/368)

The expression of interleukin 10 (IL-10) is correlated with clinical prognosis in non-small cell lung cancer [NSCLC (H. Hatanaka et al., ANN: ONCOL:, 11: 815--819, 2000)]. However, the effects of IL-10 expression on vascularization in NSCLC are not apparent. We examined the gene expression of IL-10/IL-10 receptor and various angiogenic/angioinhibitory factors in 95 NSCLC samples to determine the correlation between IL-10 production and vascularization. Vascular endothelial growth factor, angiopoietin [Ang (Ang-1 and Ang-2)], thrombospondin, brain-specific angiogenesis inhibitor 1, vascular endothelial growth factor receptors (KDR and flt-1), and Ang receptor (TIE2) gene expression were evaluated by reverse transcription-PCR. The cellular localization of these factors and vascularity in the cancer stroma were examined immunohistochemically. Seventy-eight (82.1%) and 93 (97.9%) of these 95 NSCLCs were positive for IL-10 and IL-10 receptor, respectively. Ang-1, Ang-2, and TIE2 gene expression was seen in 76 (97.4%), 73 (93.6%), and 78 (100%) of 78 IL-10-positive NSCLCs, respectively, and was significantly correlated with IL-10 gene expression (P < 0.0088, <0.0008, and 0.0305, respectively; Fisher's exact method). The localizations of Ang-1, Ang-2, and TIE2 were confirmed within tumor cells immunohistochemically. Vascular number and measurement area were significantly higher in the IL-10-positive NSCLCs (33.500 +/- 9.299/microm(2) and 4.742 +/- 1.287%) as compared with IL-10-negative NSCLCs (10.611 +/- 2.839/microm(2) and 0.718 +/- 0.331%; Mann-Whitney U test, P = 0.0039). The IL-10 expression did not show any significant correlation with the expression of other factors. These results suggested that tumor-produced IL-10 promotes stromal vascularization through expression of Ang-1, Ang-2, and TIE2.  (+info)

Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. (4/368)

The brain-specific angiogenesis inhibitor 1 gene has been isolated in an attempt to find fragments with p53 "functional" binding sites. As reported herein and by others, brain-specific angiogenesis inhibitor 1 expression is present in some normal tissues, but is reduced or lost in tumour tissues. Such data and its particular structure prompted the hypothesis that brain-specific angiogenesis inhibitor 1 may act as a mediator in the local angiogenesis balance. We herein demonstrate that brain-specific angiogenesis inhibitor 1 over-expression suppresses tumour angiogenesis, delaying significantly the human tumour growth in immunodeficient mice. The inhibitory effect of brain-specific angiogenesis inhibitor 1 was documented using our intravital microscopy system, strongly implicating brain-specific angiogenesis inhibitor 1 as a mediator in the control of tumour angiogenesis. In contrast, in vitro tumour cell proliferation was not inhibited by brain-specific angiogenesis inhibitor 1 transfection, whereas some level of cytotoxicity was assessed for endothelial cells. Immunohistochemical analysis of tumour samples confirmed a reduction in the microvessel density index in brain-specific angiogenesis inhibitor 1-overexpressing tumours. At messenger level, moderate changes could be detected, involving the down-regulation of vascular endothelial growth factor and collagenase-1 expression. Furthermore, brain-specific angiogenesis inhibitor 1 expression that was lost in a selection of human cancer cell lines could be restored by wild-type p53 adenoviral transfection. Brain-specific angiogenesis inhibitor 1 should be considered for gene therapy and development of efficient drugs based on endogenous antiangiogenic molecules.  (+info)

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. (5/368)

PDZ domains typically interact with the very carboxyl terminus of their binding partners. Type 1 PDZ domains usually require valine, leucine, or isoleucine at the very COOH-terminal (P(0)) position, and serine or threonine 2 residues upstream at P(-2). We quantitatively defined the contributions of carboxyl-terminal residues to binding selectivity of the prototypic interactions of the PDZ domains of postsynaptic density protein 95 (PSD-95) and its homolog synapse-associated protein 90 (SAP102) with the NR2b subunit of the N-methyl-d-aspartate-type glutamate receptor. Our studies indicate that all of the last five residues of NR2b contribute to the binding selectivity. Prominent were a requirement for glutamate or glutamine at P(-3) and for valine at P(0) for high affinity binding and a preference for threonine over serine at P(-2), in the context of the last 11 residues of the NR2b COOH terminus. This analysis predicts a COOH-terminal (E/Q)(S/T)XV consensus sequence for the strongest binding to the first two PDZ domains of PSD-95 and SAP102. A search of the human genome sequences for proteins with a COOH-terminal (E/Q)(S/T)XV motif yielded 50 proteins, many of which have not been previously identified as PSD-95 or SAP102 binding partners. Two of these proteins, brain-specific angiogenesis inhibitor 1 and protein kinase Calpha, co-immunoprecipitated with PSD-95 and SAP102 from rat brain extracts.  (+info)

Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (6/368)

Brain angiogenesis inhibitors (BAI) are putative transmembrane proteins containing an extracellular domain with thrombospondin type-1 repeats which can exhibit anti-angiogenic activity. BAI1 mRNA is expressed mainly in the brain, while BAI2 and BAI3 mRNAs are more widely expressed. We hypothesized that the BAI family might have anti-tumoral properties and studied the expression of BAI1 protein in normal human brain and in glioblastoma multiforme. We generated an anti-BAI1 antibody and showed that BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated. BAI1 expression did not correlate with TP53 status and we did not confirm previous findings that p53 regulates BAI1 mRNA expression in glioma cells. The finding that expression of BAI proteins may be lost during tumor formation is of special interest as restoration of their function in tumors may be of therapeutic benefit.  (+info)

Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. (7/368)

Vascular endothelial growth factor (VEGF)-mediated angiogenesis is essential for bone formation. However, the effect of VEGF on osteoblastic cells during osteoblastogenesis is still controversial. The aim of this study was to clarify the relationship between osteoblastic cells derived from human mesenchymal stem cells (MSCs) and VEGF in the early stage of osteoblastic differentiation. Continuous dexamethasone treatment with a low concentration stimulated osteoblastogenesis of MSCs and the expression of VEGF121 mRNA. The VEGF secretion from osteoblastic cells also increased along with osteoblastogenesis. Neuropilin-1, which mainly binds VEGF165, was detected at all stages during early osteoblastogenesis, but VEGF receptor-1 and -2 were not detected on RT-PCR analyses. In this study, VEGF had no direct effect on the proliferation of osteoblastic cells. However, the secreted VEGF in the conditioned medium of osteoblastic cells exhibited high angiogenic power as to endothelial cell proliferation. Our findings indicated that VEGF121 principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. The present study also demonstrated the differential expression of VEGF121 during osteoblastogenesis. The increase of VEGF in the early stage might be a useful marker of induction of bone formation due to human MSCs.  (+info)

Circulating proangiogenic cytokines and angiogenesis inhibitor endostatin in untreated patients with chronic lymphocytic leukemia. (8/368)

The serum concentration of two pro-angiogenic cytokines: basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF-beta1), and anti-angiogenic factor endostatin in the serum of 80 never treated B-cell chronic lymphocytic leukemia (CLL) patients and 27 healthy volunteers was measured using an enzyme linked immunosorbent assay. The serum levels of both bFGF and TGF-beta1 were found to be significantly higher in the CLL group (median 40.5 pg/ml and 38.6 ng/ml respectively) when compared to the control group (median 9.4 pg/ml and 18.9 ng/ml, respectively) (p<0.001). The levels of endostatin were not significantly different in CLL and control groups (median 12.3 ng/ml and 8.4 ng/ml, respectively) (p=0.09). In the group of CLL patients the level of bFGF was significantly higher in patients with progressive disease as compared with patients with stable disease (median 90.5 pg/ml and 40.5 pg/ml respectively) (p<0.001). Patients in Rai stage III and IV also had significantly higher levels of bFGF than patients in Rai stage 0-II (median 100.1 pg/ml and 29.3 pg/ml respectively) (p<0.001). The levels of both TGF-beta1 and endostatin were lower in patients in Rai stage III and IV (median 28.9 ng/ml and 9.1 ng/ml respectively) than in patients in Rai stage 0-II (42.8 ng/ml and 13.1 ng/ml respectively) (p<0.001 and p=0.002 respectively). The level of endostatin was also lower in the group of CLL patients with progressive disease (median 10.0 ng/ml) as compared to patients with stable disease (median 20.5 ng/ml) (p=0.008). In conclusion, the disturbance in the balance between pro- and anti-angiogenic factors may have an important influence on the course of CLL.  (+info)

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3-end of this gene results in three products of undetermined function.[2] ...
BAI2 antibody (brain-specific angiogenesis inhibitor 2) for IHC-P. Anti-BAI2 pAb (GTX71911) is tested in Human samples. 100% Ab-Assurance.
BAP3 was initially identified through interaction in a yeast two-hybrid system with the brain-specific angiogenesis inhibitor 1, a p53-target gene that encodes a seven-span transmembrane protein member of the secretin receptor family. BAP3 is predominantly expressed in the brain and possess high homology with Munc13 and synaptotagmin, suggesting that BAP3 may play a role in regulating neurotransmitter release. Recent experiments have shown that BAP3 is induced in certain tumors such as desmoplastic small round cell tumor. Ectopic expression of BAP3 in tumor cells dramatically enhances growth in low serum conditions and colony formation in soft agar, suggesting that the regulated exocytotic pathway may play a role in cancer cell proliferation. BAP3 is known to have two isoforms; this BAP3 antibody will recognize only isoform 2. Lower molecular weight bands may represent cleavage or degradation products. ...
This is the first report that Del-1 is expressed in adult animals in response to ischemia and that it plays an important role in adult angiogenesis. The protein encoded by Del-1 plays a critical role in embryonic vascular development. However, at the time of birth, the gene becomes quiescent, and Del-1 is no longer expressed in normal adult tissues.. In the embryo, Del-1 is expressed by endothelial progenitor cells and is secreted into the extracellular matrix.1 Del-1 supports adherence and migration of endothelial cells, mediated largely through the αvβ3 integrin receptor. Accumulating evidence indicates that angiogenesis requires signaling through both growth factor and integrin signaling pathways. Endothelial cells deprived of either influence will undergo programmed cell death.12 Indeed, in the chick CAM assay, antibodies directed against αvβ3 suppress Del-1-induced angiogenesis.13 A mutant form of Del-1, when the RGD motif has been altered (RGD→RAD), also disrupts angiogenesis in this ...
Product Pig Angiogenic factor with G patch and FHA domains 1(AGGF1) ELISA kit From B-Gene - A competitive ELISA for quantitative measurement of Porcine Angiogenic factor with G patch and FHA domains 1(AGGF1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUTION*1 vial 12. WASH SOLUTION (100 x)*1 vial 13. BALANCE SOLUTION*1 vial 14. INSTRUCTION*1
Background: During brain development, chemical cues released by developing neurons, cellular signaling with pericytes, and mechanical cues within the brain extracellular matrix (ECM) promotes angiogenesis occurs of brain microvascular endothelial cells (BMECs).  During brain dis...
The energy requirements of the brain are large and immediate. The need to deliver adequate oxygen and glucose and to remove carbon dioxide specifies the vascular architecture. Taken as a whole, the...
Bai Yue is a medicine available in a number of countries worldwide. A list of US medications equivalent to Bai Yue is available on the Drugs.com website.
0005] One embodiment of the invention provides a method of detecting cancer or a predisposition to developing cancer in a subject. The method comprises determining an expression level of a cancer-associated polynucleotide, protein, or polypeptide selected from the group consisting of Titin; HBA1; Insulin-like growth factor 1 receptor (IGF1R); Isoform 3 of zonadhesin precursor; latent transforming growth factor beta binding protein 4 (LTBP4); ASXL1 (additional sex combs like 1); beta globin (HBB); BMP15-bone morphogenetic protein; TRIM49; DNAJ homolog subfamily B member 11 precursor; uncharacterized hematopoietic stem/progenitor cells protein MDS027; uncharacterized protein ALB; isoform 3 of sushi, nidogen and EGF-like domain-containing protein 1 precursor; isoform 2 of peripherin; mitochondrial 28S ribosomal protein S22; translation initiation factor EIF-2B subunit epsilon; estradiol 17-beta-dehydrogenase 1; XRCC6BP1; brain-specific angiogenesis inhibitor 1 precursor; isoform 2 of ring finger ...
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1 gene. The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. MAGI1 has been shown to interact with: ACCN3, ATN1, Actinin alpha 4, Beta-catenin, Brain-specific angiogenesis inhibitor 1, Calcium-activated potassium channel subunit alpha-1, FCHSD2, LRP2, and SYNPO. ENSG00000151276 GRCh38: Ensembl release 89: ENSG00000282956, ENSG00000151276 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000045095 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Shiratsuchi T, ...
The ultimate goal of this proposal is to understand the contribution of Vstat120 expressing oncolytic viruses on OV propagation, tumor biology and anti-tumor ef...
Angiogenin is a potent angiogenic protein whose inhibition is known to prevent human tumor growth in athymic mice. It is secreted by both tumor and normal cells; and interacts with endothelial and smooth muscle cells to induce a wide range of cellular responses including cell migration and invasion, …
Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
My research has focused on several basic and translational aspects of cancer biology. From a basic science perspective, my lab cloned NOL7, a novel gene that induces an anti-angiogenic phenotype and suppresses in vivo tumor growth. NOL7 acts as a master regulator of angiogenesis by modulating the expression of angiogenesis-associated mRNAs via both steady-state downregulation and posttranscriptional upregulation. NOL7 itself is positively regulated by the retinoblastoma (Rb) gene, supporting the paradigm shift that Rb can act as a positive regulator of gene transcription. Our long-term goal is to understand how transcriptional and posttranscriptional regulation of angiogenesis-related mRNAs contributes to the expression of the phenotype and to leverage this knowledge to develop novel therapeutic approaches. Our central hypothesis is that Rb positively regulates NOL7 expression and that loss of NOL7 protein expression results in decreased regulation of NOL7 target mRNA transcripts, the gain of ...
Sigma-Aldrich offers abstracts and full-text articles by [Maosheng Zhan, Yumiko Hori, Naoki Wada, Jun-Ichiro Ikeda, Yuuki Hata, Keigo Osuga, Eiichi Morii].
TY - JOUR. T1 - Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell-based spheroids in a 3D matrix. AU - Kim, Sook Kyoung. AU - Lee, Jaeyeon. AU - Song, Myeongjin. AU - Kim, Mirim. AU - Hwang, Soon Jung. AU - Jang, Hwanseok. AU - Park, Yongdoo. PY - 2015. Y1 - 2015. N2 - Combinations of angiogenic growth factors have been shown to have synergistic effects on angiogenesis and natural wound healing in various animal models. Each growth factor has unique roles during angiogenesis; vascular endothelial growth factor (VEGF) plays a key role during the initial step of angiogenesis, whereas PDGF functions in the maturation of blood vessels. We used a combination of three angiogenic growth factors to increase angiogenesis in vitro and in vivo. We chose VEGF as a basic factor and added platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) to induce angiogenesis in three in vitro and in vivo models: 3D ...
Anat Rec (Hoboken). 2013 Aug;296(8):1161-8. doi: 10.1002/ar.22676. Epub 2013 Jun 6. Comparative Study; Research Support, Non-U.S. Govt
Christensen, A C M and Haresign, W and Khalid, M (2014) Progesterone exposure of seasonally anoestrous ewes alters the expression of angiogenic growth factors in preovulatory follicles. Theriogenology, 81 (2). pp. 358-367. ...
Therapeutic angiogenesis remains a worthy but somewhat elusive clinical goal. Attempts to increase blood flow to ischemic tissue have included a variety of physical and biological approaches. A growing understanding of the cells and proteins involved in vessel sprouting and maturation led to a number of genetic approaches aimed at promoting angiogenesis in ischemic myocardium and skeletal muscle. In spite of several strategies undergoing testing in clinical trials, the delivery of vectors encoding for single growth factors has not yet shown clinical efficacy. In response to these challenges, a number of groups have aimed to provide multiple angiogenic factors for ischemic tissue. These approaches include gene transfer of transcription factors that regulate multiple angiogenic peptides (such as hypoxia inducible factor-1 ) or transplantation of cells capable of providing a regulated source of secreted growth factors and cytokines. A potential advantage of delivered cells is that they may also directly
They developed an angiogenic microfiber patch that releases angiogenic growth factors along aligned fibers and subsequently directs the spacing and orientation of mature and functional neovessels. The angiogenic microfiber patch was prepared by electrostatically binding electrosprayed angiogenic growth factor-encapsulating polymeric microparticles with electrospun polymeric microfibers. The microparticles released the angiogenic growth factors in a sustained manner, while the straightly aligned polymeric fibers guided cells to adhere along their orientation.. The patch will be highly useful in treating cardiovascular disease, which is the leading cause of death and disability of people all over the world, Kong said.. Their work was reported in Advanced Materials in late July.. ...
Looking for online definition of angiogenic in the Medical Dictionary? angiogenic explanation free. What is angiogenic? Meaning of angiogenic medical term. What does angiogenic mean?
Adrenomedullin promotes formation of xenografted endometrial tumors by stimulation of autocrine growth and angiogenesis.: The angiogenic peptide adrenomedullin
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VG5Q functions as an angiogenic factor in promoting angiogenesis and suppression of VG5Q expression inhibits vessel formation. Angiogenic factors are…
Definition of angiogenic gene therapy in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is angiogenic gene therapy? Meaning of angiogenic gene therapy as a finance term. What does angiogenic gene therapy mean in finance?
TY - JOUR. T1 - Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. AU - Bosch-Marce, Marta. AU - Okuyama, Hiroaki. AU - Wesley, Jacob B.. AU - Sarkar, Kakali. AU - Kimura, Hideo. AU - Liu, Ye V.. AU - Zhang, Huafeng. AU - Strazza, Marianne. AU - Rey, Sergio. AU - Savino, Lindsey. AU - Zhou, Yi Fu. AU - McDonald, Karin R.. AU - Na, Youn. AU - Vandiver, Scott. AU - Rabi, Alireza. AU - Shaked, Yuval. AU - Kerbel, Robert. AU - LaVallee, Theresa. AU - Semenza, Gregg L.. PY - 2007/12/1. Y1 - 2007/12/1. N2 - Ischemia is a stimulus for production of angiogenic cytokines that activate local vascular cells and mobilize angiogenic cells to the circulation. These responses are impaired in elderly patients with peripheral arterial disease. Hypoxia-inducible factor (HIF)-1 mediates adaptive responses to ischemia, including production of angiogenic cytokines. In this study, we demonstrate that aging and HIF-1 loss-of-function ...
We have previously shown that intracoronary delivery of recombinant adenoviruses encoding angiogenic proteins that contain signal peptides (fibroblast growth factor-4 and fibroblast growth factor-5) ameliorate myocardial ischemia. In the present paper, we test the hypothesis that the presence of the signal peptide is an important element in the favorable effects that transgene expression has on regional flow and function in an animal model of myocardial ischemia. We performed intracoronary delivery of two different recombinant adenoviruses encoding a fibroblast growth factor-2 variant, one with a signal peptide, FGF-2LI(+sp), and one without a signal peptide, FGF-2LI(-sp). In a model of stress-induced myocardial ischemia, intracoronary injection of these recombinants resulted in mRNA and protein expression of the transferred gene. Two weeks after gene transfer, regional abnormalities in stress-induced function and blood flow were improved after delivery of FGF-2LI containing the signal peptide. ...
PRIMARY OBJECTIVES:. I. To evaluate the response rate of chemotherapy-refractory sarcomas to 20 mg per day of single-agent Ang(Angiotensin)-(1-7) or 10 mg per day of single-agent Ang-(1-7) if excessive toxicity is observed at the 20 mg dose.. II. To evaluate toxicities associated with single-agent Ang-(1-7) when given to patients with chemotherapy-refractory sarcomas.. SECONDARY OBJECTIVES:. I. To assess time to progression (TTP) and overall survival (OS) in patients treated with Ang-(1-7).. II. To evaluate accumulation of Ang-(1-7) after 21 days of continuous treatment and quantify changes in plasma levels of angiogenic peptides including placental growth factor (PlGF).. OUTLINE:. Patients receive therapeutic angiotensin-(1-7) subcutaneously (SC) once daily in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter. ...
Advanced St IIIB/IV NS-NSCLC p with ECOG 0-2 prospectively included and treated 1st-line with CP-Bev 6 cycles followed by Bev maintenance. Primary end-point: PFS; secondary end-points: OS, RR, toxicity. Ancillary study designed to investigate relationship between angiogenic mediators, response and outcomes. Ethical approval and informed consent for collecting peripheral blood samples and associated clinical data. Samples collected before treatment (basal) and at response evaluation (post). DNA obtained from leukocyte fraction. SNPs of angiogenic genes genotyped by PCR. Plasma levels of VEGFA and VEGFR2 determined by ELISA. Response RECIST.1 and toxicity CTCAEv.1. ...
We investigated whether the angiogenic profile, which is based on the local expression and systemic levels of angiogenic growth factors (VEGF, Ang-1, Ang-2, and the corresponding receptors), differs between rheumatoid arthritis (RA) and osteoarthritis (OA) patients. We determined the expression of VEGF, Ang-1, and Ang-2 together with its receptors (VEGFR-1/-2 ...
Sigma-Aldrich offers abstracts and full-text articles by [M C Ramello, J Tosello Boari, F P Canale, H A Mena, S Negrotto, B Gastman, A Gruppi, E V Acosta Rodríguez, C L Montes].
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Klippel-Trenaunay syndrome is a birth (congenital) condition that affects the development of blood vessels, soft tissue and bones.
Klippel-Trenaunay syndrome is a birth (congenital) condition that affects the development of blood vessels, soft tissue and bones.
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TY - JOUR. T1 - Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. AU - Bosch-Marce, Marta. AU - Okuyama, Hiroaki. AU - Wesley, Jacob B.. AU - Sarkar, Kakali. AU - Kimura, Hideo. AU - Liu, Ye V.. AU - Zhang, Huafeng. AU - Strazza, Marianne. AU - Rey, Sergio. AU - Savino, Lindsey. AU - Zhou, Yi Fu. AU - McDonald, Karin R.. AU - Na, Youn. AU - Vandiver, Scott. AU - Rabi, Alireza. AU - Shaked, Yuval. AU - Kerbel, Robert. AU - LaVallee, Theresa. AU - Semenza, Gregg L.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2007/12. Y1 - 2007/12. N2 - Ischemia is a stimulus for production of angiogenic cytokines that activate local vascular cells and mobilize angiogenic cells to the circulation. These responses are impaired in elderly patients with peripheral arterial disease. Hypoxia-inducible factor (HIF)-1 mediates adaptive responses to ischemia, including production of angiogenic cytokines. In ...
Neuroinflammation and blood-brain barrier (BBB) disruption are two critical mechanisms of subarachnoid hemorrhage (SAH)-induced brain injury, which are closely related to patient prognosis. Recently, angiogenic factor with G-patch and FHA domain 1 (Aggf1) was shown to inhibit inflammatory effect and preserve vascular integrity in non-nervous system diseases. This study aimed to determine whether Aggf1 could attenuate neuroinflammation and preserve BBB integrity after experimental SAH, as well as the underlying mechanisms of its protective roles. Two hundred forty-nine male Sprague-Dawley rats were subjected to the endovascular perforation model of SAH. Recombinant human Aggf1 (rh-Aggf1) was administered intravenously via tail vein injection at 1 h after SAH induction. To investigate the underlying neuroprotection mechanism, Aggf1 small interfering RNA (Aggf1 siRNA) and PI3K-specific inhibitor LY294002 were administered through intracerebroventricular (i.c.v.) before SAH induction. SAH grade,
CASE SUMMARY A 5-month-old girl presented with recurrent seizures. The child was born at 36 weeks via C-section due to prenatal ultrasound abnormalities of t...
Introduction: We have previously shown that treatment with epidermacan a novel stem cell derived paracrine factor promoted angiogenesis in vitro accompanied with an increase in angiogenic miRNA expression. Here, we identified novel microRNAs regulated by epidermacan and validated their importance in modulating the epidermacan angiogenic effects in vitro and in vivo.. Methods and Results: Increased levels of pro-angiogenic miRNAs such as miR-10b, miR-21 and miR-424 were discovered in MicroRNA profiling of HUVEC cells treated with epidermacan and then confirmed by qRT-PCR. We also identified miR-874, a relatively unknown miRNA but for its role as a tumor suppressor. Investigation of the downstream microRNA/gene networks revealed that epidermacan regulated known angiogenic genes such as VEGFC, TBX1, HIF-1a and NRP1. Importantly, treatment with epidermacan decreased the levels of HoxD10, a known target of miR-10b in thrombin induced angiogenesis. Inhibition of miR-10b or miR-874 via anti-miR ...
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Background Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as...
Low expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity ...
Sierra-Honigmann, M.R., Nath, A.K., Murakami, C., Garcia-Cardena, G, Papapetropoulos, A., Sessa, W.C., Madge, L.A., Schechner, J.S., Schwabb, M.B., Polverini, P.J., and Flores-Riveros, J.R. (1998) Biological action of leptin as an angiogenic factor. Science 281:1683-1686 ...
Read about the journeys of our patients with Klippel-Trenaunay Syndrome from experts at Boston Childrens, ranked best Childrens Hospital by US News.
Learn about the programs and services for Klippel-Trenaunay Syndrome at Boston Childrens, ranked best Childrens Hospital by US News.
Timely regulated changes in oxygen partial pressure are important for placental formation. Disturbances could be responsible for pregnancy-related diseases like preeclampsia and intrauterine growth restriction. We aimed to (i) determine the effect of oxygen partial pressure on cytotrophoblast differentiation; (ii) measure mRNA expression and protein secretion from genes associated with placental angiogenesis; and (iii) determine the reversibility of these effects at different oxygen partial pressures. Term cytotrophoblasts were incubated at 21% and 2.5% O2 for 96 hr, or were switched between the two oxygen concentrations after 48 hr. Real-time PCR and enzyme-linked immunosorbent assays (ELISAs) were used to evaluate cell fusion and differentiation, measuring transcript levels for those genes involved in cell fusion and placental angiogenesis, including VEGF, PlGF, VEGFR1, sVEGFR1, sENG, INHA, and GCM1. Cytotrophoblasts underwent fusion and differentiation in 2.5% O2 . PlGF expression was ...
TY - JOUR. T1 - DC electric stimulation upregulates angiogenic factors in endothelial cells through activation of VEGF receptors. AU - Bai, Huai. AU - Forrester, John V.. AU - Zhao, Min. PY - 2011/7. Y1 - 2011/7. N2 - Small direct current (DC) electric fields direct some important angiogenic responses of vascular endothelial cells. Those responses indicate promising use of electric fields to modulate angiogenesis. We sought to determine the regulation of electric fields on transcription and expression of a serial of import angiogenic factors by endothelial cells themselves.Using semi-quantitative PCR and ELISA we found that electric stimulation upregulates the levels of mRNAs and proteins of a number of angiogenic proteins, most importantly VEGF165, VEGF121 and IL-8 in human endothelial cells. The up-regulation of mRNA levels might be specific, as the mRNA encoding bFGF, TGF-beta and eNOS are not affected by DC electric stimulation at 24. h time-point. Inhibition of VEGF receptor (VEGFR1 or ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Publishers, Placental Growth Factor (PIGF) Blockers-Pipeline Insights, 2016″, report provides in depth insights on the pipeline drugs and their development activities around the Placental Growth Factor (PIGF) Blockers. The Publishers Report covers the product profiles in various stages of development including Discovery, Pre-clinical, IND, Phase I, Phase II, Phase III and Preregistration. Report covers the product clinical trials information and other development activities including technology, licensing, collaborations, acquisitions, fundings, patent and USFDA & EMA designations details. Publishers Report also provides detailed information on the discontinued and dormant drugs that have gone inactive over the years for Placental Growth Factor (PIGF) Blockers. Publishers Report also assesses the Placental Growth Factor (PIGF) Blockers therapeutics by Monotherapy, Combination products, Molecule type and ...
Angiogenesis is the formation of new blood vessels from existing vasculature. Vascular Endothelial Growth Factor (VEGF), a known angiogenic protein, stimulates endothelial cell proliferation and migration via interactions with its receptors, KDR and Flt-1. A secreted form of Flt-1 (sFlt-1), derived from alternatively-spliced RNA, can inhibit actions of VEGF in vivo. It has been suggested that alterations in sFlt-1 expression could significantly change the angiogenic VEGF activity. This project focuses on characterizing intronic elements that regulate Flt-1 mRNA splicing. A wild-type construct (pFIN13), containing the first 13 exons, intron 13 and exons 14-30 of mouse Flt-1, was shown to produce both forms of Flt-1 mRNA after transfection into HEK293 cells. To gauge the strength of the native splicing signals in intron 13 of Flt-1, a series of point mutations were made in the polypyrimidine tract using pFIN13. After transient transfection, the levels of Flt-1 and sFlt-1 protein and mRNA were ...
Endometriosis is a chronic, inflammatory disease characterized by the growth of endometrial tissue in aberrant locations outside the uterus. Neoangiogenesis or establishment of new blood supply is one of the fundamental requirements of endometriotic lesion survival in the peritoneal cavity. IL-17A is emerging as a potent angiogenic and proinflammatory cytokine involved in the pathophysiology of several chronic inflammatory diseases such as rheumatoid arthritis and psoriasis. However, sparse information is available in the context of endometriosis. In this study, we demonstrate the potential importance of IL-17A in the pathogenesis and pathophysiology of endometriosis. The data show a differential expression of IL-17A in human ectopic endometriotic lesions and matched eutopic endometrium from women with endometriosis. Importantly, surgical removal of lesions resulted in significantly reduced plasma IL-17A concentrations. Immunohistochemistry revealed localization of IL-17A primarily in the stroma ...
Comment Bubble I have a dream! Im calling it the International K-T House & Mentor Program*. So many parents first learn of Klippel-Trenaunay Syndrome when their child is born with it. Those moments are often frantic moments, particularly for parents whose children are born looking very different from the picture they had in mind. Making this experience…
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Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mair un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ANGPT2. ...
Bai is known for its low-calorie antioxidant infusions, available in different flavors. But is bai healthy, and could you replace water with it? We take a look.
... is protein that in humans is encoded by the TNFSF15 gene. VEGI is an anti-angiogenic protein. It belongs to tumor necrosis ... Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) ... This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this ... It is the sole known ligand for death receptor 3, and it can also be recognized by decoy receptor 3. The protein encoded by ...
Circulating angiogenic proteins trisomy 12 Am J Obstet Gynecol. 2006 Jan:194(1):239-45 Sachs BP, A Woman with Fetal Loss - ... Circulating Angiogenic Factors and the Risk of Preeclampsia. NEJM 2004; 350:672-83 Levine RJ, Thadhani R, Qian C, Lam C, Lim KH ... a novel circulating anti-angiogenic factor in preeclampsia. N Engl J Med 2006;355:992-1005 Nielsen P, Goldman M, Mann S, ...
January 1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Bonaldo ... Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein is a transmembrane (type I) heparan sulfate ... The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and ... Indatuximab ravtansine targets this protein. It is a useful marker for plasma cells, but only if the cells tested are already ...
"HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Kojima T, Katsumi A, ... The protein is found as a homodimer and is a member of the syndecan proteoglycan family. Syndecan-4 interacts with ... Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has ... Syndecan-4 activates protein kinase C (PKC), an enzyme involved in signal transduction. The variable domain of syndecan-4 could ...
January 2000). "The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma". Journal of Leukocyte Biology. 67 (1 ... In humans, this protein is encoded by the gene Cxcl1 and is located on human chromosome 4 among genes for other CXC chemokines ... It was previously called GRO1 oncogene, GROα, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity ... for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins ...
1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Chernousov MA, ... Hakansson S, Jacobs A, Caffrey M (2001). "Heparin binding by the HIV-1 tat protein transduction domain". Protein Sci. 10 (10): ... Syndecan-3 is a protein that in humans is encoded by the SDC3 gene. GRCh38: Ensembl release 89: ENSG00000162512 - Ensembl, May ... "Entrez Gene: SDC3 syndecan 3". Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency ...
... cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV. These proteins, ... is a novel angiogenic regulator of the CCN protein family". The Journal of Biological Chemistry. 278 (26): 24200-8. doi:10.1074 ... The human NOV protein contains 357 amino acids with an N-terminal secretory signal peptide followed by four structurally ... Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B (Feb 1999). "The C-terminal domain of the regulatory protein NOVH ...
... and anti-angiogenic effects. In biomarker studies, the protein has been found to have potential prognostic and diagnostic value ... "Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes". The ... The HRG protein is produced in the liver, and it could also be synthesized by monocytes, macrophages, and megakaryocytes. It ... Two of the protein's effects, the inhibition of fibrinolysis and the reduced inhibition of coagulation, indicate a potential ...
These gene products may include proteins such as glycolytic enzymes and angiogenic growth factors. In normoxia, HIF alpha ... 1996). "SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscle". Lab. Invest. 74 ( ... Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2), or prolyl hydroxylase domain-containing protein 2 (PHD2), is an enzyme ... 2006). "Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia- ...
The angiogenic switch downregulates angiogenesis suppressor proteins, such as thrombospondin, angiostatin, endostatin and ... GSCs are easily identified through histological staining against vasa protein (to identify germ cells) and 1B1 protein (to ... Angiogenesis induced by hypoxic conditions is called an "Angiogenic switch". HIF-1 promotes expression of several angiogenic ... But there is evidence that the expression of angiogenic agens by cancer cells can also be HIF-1 independent. It seems that ...
2015-01-26). "Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea". PLOS ONE. ... TMEM155 protein is 130 amino acids in length. The TMEM155 protein in its full form is 14.2 kD in molecular weight with an ... Transmembrane protein 155 is a protein that in humans is encoded by the TMEM155 gene. It is located on human chromosome 4, ... This protein is known to be expressed mainly in the brain, placenta, and lymph nodes and is conserved throughout most placental ...
"Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity". The Journal ... This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to ... "Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell ... the remaining anti-angiogenic domains have been shown to have decreased anti-angiogenic activity at low concentrations where ...
... an angiogenic protein, at 2.0 A resolution". The Journal of Biological Chemistry. 276 (15): 12153-61. doi:10.1074/jbc. ... Placental growth factor is a protein that in humans is encoded by the PGF gene. Placental growth factor (PGF) is a member of ... There are three isoforms of this protein: PGF-1, PGF-2, PGF-3. PGF-1 is specifically found in the colon as well as mammary ... The placental growth factor (PGF) gene is a protein-coding gene and a member of the vascular endothelial growth factor (VEGF) ...
... and angiogenic proteins linked to proinflammatory pathway". The Journal of Biological Chemistry. 285 (35): 26987-97. doi: ... 2 January 2012). "3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to ... 22 October 2010). "γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine ... May 2008). "Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, ...
"Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1". ... This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins belong to the alpha-ketoglutarate- ... They are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative ... "Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1". ...
This protection appears to be due to the elevated levels of endostatin, an anti-angiogenic protein, derived from collagen XVIII ... An experimental study suggests that pericyte death is caused by blood glucose persistently activating protein kinase C and ... mitogen-activated protein kinase (MAPK), which, through a series of intermediates, inhibits signaling through platelet-derived ...
December 2010). "CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic ... Silmitasertib (INN), codenamed CX-4945, is a small-molecule inhibitor of protein kinase CK2 (casein kinase II), a ... the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer". Journal of Medicinal Chemistry. 54 (2): ... is increased resulting in phosphorylation of several cytoskeletal proteins. These infected cells also display CK2-containing ...
Nam, J. O.; Jung, M. Y.; Thapa, N.; Lee, B. H.; Park, R. W.; Kim, I. S. (2008). "T-CAM, a fastatin-FIII 9-10 fusion protein, ... potently enhances anti-angiogenic and anti-tumor activity αvβ3 and α5β1 integrins". Experimental & Molecular Medicine. 40 (2): ... Nam, J. -O.; Son, H. -N.; Jun, E.; Cha, K.; Lee, B. -H.; Park, R. -W.; Kim, I. -S. (2012). "FAS1 Domain Protein Inhibits ... Thapa, N.; Lee, B. H.; Kim, I. S. (2007). "TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β". The ...
... pro-angiogenic protein therapy uses well-defined, precisely structured proteins, with previously defined optimal doses of the ... which angiogenic research began with, and pro-angiogenic therapies. Whereas anti-angiogenic therapies are being employed to ... Chemical stimulation of angiogenesis is performed by various angiogenic proteins e.g. integrins and prostaglandins, including ... As part of the angiogenic signaling cascade, NO is widely considered to be a major contributor to the angiogenic response ...
These effects are mediated by interacting and interfering with various angiogenic related proteins such as integrins and serine ... "Structure-function analysis of the ADAM family of diintegrin-like and metalloproteinase-containing proteins". J. Protein Chem. ... Native proteins which contain such domains with regulatory activity are normally inactive, most likely because they are cryptic ... Monocytes produce a variety of pro-angiogenic factors. There is also a population of CD34 positive cells that can express ...
Slevin M, Krupinski J, Kumar S, Gaffney J (August 1998). "Angiogenic oligosaccharides of hyaluronan induce protein tyrosine ... HYAL1 is implicated in several types of cancers, likely due to the angiogenic effects of HYAL1-cleaved hyaluronan fragments. In ...
... includes proteins that are angiogenic factors. The presence of the cyclic cystine knot (CCK) motif was discovered when ... Novel proteins are being added to the cystine knot motif family, also known as the C-terminal cystine knot (CTCK) proteins. ... The cystine knot motif stabilizes protein structure and is conserved in proteins across various species. There are three types ... Studies have shown that cystine knot proteins can be incubated at temperatures of 65 °C or placed in 1N HCl/1N NaOH without ...
6,0 6,1 6,2 Bargahi A, Rabbani-Chadegani A (Februar 2008). »Angiogenic inhibitor protein fractions derived from shark cartilage ... A novel polypeptide from shark cartilage with potent anti-angiogenic activity«. Cancer Biology & Therapy 6 (5): 775-780. PMID ... Identification of low-molecular-weight protein (SCP1) from shark cartilage with anti-angiogenesis activity and sequence ...
Studies have shown that proteins found in tight junctions serve as intermediaries that moderate angiogenic signaling pathways. ... They interact in their cytoplasmic domain with scaffold proteins that contain a PDZ domain, which are common protein ... Like JAM-2, JAM-3 has been shown associate with tight junction proteins like PAR-3 and ZO-1. JAM-3 has also been shown to ... Once the tight junction is formed, many JAM-1 proteins are present, many of which are now phosphorylated at Ser285. JAM-1 also ...
1997). "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer". Nat. Med. 3 (10): 1137-40. doi: ... 2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated ... Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. FGFBP1, or HBP17, binds ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ...
... is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functions. Found in ... The PEDF protein is a secreted protein of roughly 50kDa size and 418 amino acids in length. The N-terminus contains a leader ... They isolated proteins unique to RPE cells and tested the individual proteins for neurotrophic function, meaning promoting a ... This discovery demonstrated that PEDF has an asymmetrical charge distribution across the whole protein. One side of the protein ...
2003). "The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through ... Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. It belongs to the ... Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to ... 1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc ...
Numerous clinical trials were performed, either applying protein (angiogenic growth factor) therapies, such as FGF-1 or VEGF, ... Wagoner L.E.; Merrill W.; Jacobs J.; Conway G.; Boehmer J.; Thomas K.; Stegmann T.J. (2007). "Angiogenesis Protein Therapy With ... High levels of lipoprotein(a), a compound formed when LDL cholesterol combines with a protein known as apolipoprotein(a). ... Research efforts are focused on new angiogenic treatment modalities and various (adult) stem-cell therapies. A region on ...
... splice site determines whether the proteins are pro-angiogenic (proximal splice site, expressed during angiogenesis) or anti- ... Zan L, Zhang X, Xi Y, Wu H, Song Y, Teng G, Li H, Qi J, Wang J (2014). "Src regulates angiogenic factors and vascular ... A number of VEGF-related proteins encoded by viruses (VEGF-E) and in the venom of some snakes (VEGF-F) have also been ... The overexpression of VEGF-A may be an early step in the process of metastasis, a step that is involved in the "angiogenic" ...
Gabriele Bergers, Laura E. Benjamin: Angiogenesis: Tumorigenesis and the angiogenic switch. (PDF; 2,4 MB). In: Nature Reviews ... nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis. In: Cancer Cell. Band 1, Nr. 2, März 2002, S. ...
Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... Pegaptanib sodium injection (brand name Macugen) is an anti-angiogenic medicine for the treatment of neovascular (wet) age- ... Pegaptanib specifically binds to the 165 isoform of VEGF, a protein that plays a critical role in angiogenesis (the formation ...
Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of ... a b Proto-Oncogene+Proteins+c-sis at the US National Library of Medicine Medical Subject Headings (MeSH) ... Hannink M, Donoghue DJ (1989). "Structure and function of platelet-derived growth factor (PDGF) and related proteins". Biochim ...
... although most hyaluronidase preparations are contaminated with large amounts of angiogenic growth factors.[15] ... Available protein structures:. Pfam structures / ECOD PDB. RCSB PDB; PDBe; PDBj. PDBsum. structure summary. ...
In vivo anti-tumor activity of thalidomide is believed to be due to the potent anti-angiogenic effect and also through changes ... Cereblon is a 51 kDa protein localized in the cytoplasm, nucleus and peripheral membrane of cells in numerous parts of the body ... Further anti-tumor activity is mediated through the inhibition of apoptosis protein-2 and pro-survival effects of IGF-1, ... In 1994 Thalidomide was found to have anti-angiogenic activity and anti-tumor activity which propelled the initiation of ...
McClain WH (November 1993). "Rules that govern tRNA identity in protein synthesis". Journal of Molecular Biology. 234 (2): 257- ... "VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function". The Journal of Biological Chemistry. 280 (4): 2405-8. ... For instance, one can start with the gene for a protein that binds a certain sequence of DNA, and, by directing an unnatural ... Both classes of aminoacyl-tRNA synthetases are multidomain proteins. In a typical scenario, an aaRS consists of a catalytic ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... Three transcript variants that encode distinct proteins have been identified.[6] References[edit]. *^ a b c GRCh38: Ensembl ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... protein binding. • ephrin receptor binding. Cellular component. • anchored component of membrane. • plasma membrane. • integral ...
The MPL gene codes for a protein that acts as a receptor for thrombopoietin. A mutation in that gene, known as a W515 mutation ... 2003). "Bone marrow immunohistochemical studies of angiogenic cytokines and their receptors in myelofibrosis with myeloid ... The V617F mutation to the JAK2 protein is found in approximately half of individuals with primary myelofibrosis.[7] The V617F ... leads to the production of an abnormal thrombopoietin receptor protein, which results in the overproduction of abnormal ...
A number of proteins and signalling pathways show behaviour that can be considered paradoxical compared to their function in ... The tumors are highly angiogenic and vascular, with high levels of VEGF and bFGF expression. ...
蛋白質(英語:Template:Angiogenic proteins). 疾病. *先天(英語:Template:Congenital vascular defects) ...
proliferin-related protein. mannose 6-phosphate binding lysosomal protein[10]. One of the most recent methods that is being ... The angiogenic switch leads to tumor expression of pro-angiogenic factors and increased tumor vascularization.[4] Specifically ... Inhibiting angiogenesis requires treatment with anti-angiogenic factors, or drugs which reduce the production of pro-angiogenic ... Elice, F; Rodeghiero, F (2012). "Side effects of anti-angiogenic drugs". Thrombosis Research. 129 Suppl 1: 50-3. doi:10.1016/ ...
... a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase ... The degradation products of hyaluronan, the oligosaccharides and very low-molecular-weight hyaluronan, exhibit pro-angiogenic ... The introduction of protein-based cross-links,[66] the introduction of free-radical scavenging molecules such as sorbitol,[67] ... Wisniewski HG, Vilcek J (1997). "TSG-6: an IL-1/TNF-inducible protein with anti-inflammatory activity". Cytokine Growth Factor ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... In protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target protein. ... In DNA-ligand binding studies, the ligand can be a small molecule, ion,[1] or protein[2] which binds to the DNA double helix. ... Teif VB, Rippe K (October 2010). "Statistical-mechanical lattice models for protein-DNA binding in chromatin". Journal of ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... protein binding. Cellular component. • membrane. • plasma membrane. • anchored component of external side of plasma membrane. • ... Ephrin A5 is a protein that in humans is encoded by the EFNA5 gene.[5][6][7] ...
Zan L, Zhang X, Xi Y, Wu H, Song Y, Teng G, Li H, Qi J, Wang J. (March 2014). "Src regulates angiogenic factors and vascular ... Latour S, Veillette A (June 2001). "Proximal protein tyrosine kinases in immunoreceptor signaling". Curr. Opin. Immunol. 13 (3 ... Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H (May 1991). "Cloning of a complementary DNA for a protein-tyrosine kinase ... Sun G, Budde RJ (September 1997). "Expression, purification, and initial characterization of human Yes protein tyrosine kinase ...
... and inhibiting muscle protein breakdown (MPB).[94][95] The stimulation of muscle protein synthesis by resistance training ... are considered essential for the angiogenic and neurogenic effects of exercise in the brain. Although the action of exercise on ... Ingestion of a protein-rich meal at any point during this period will augment the exercise-induced increase in muscle protein ... the p70S6 kinase and the translation repressor protein 4EBP1).[94][96] The suppression of muscle protein breakdown following ...
Growth differentiation factor 11 (GDF11) also known as bone morphogenetic protein 11 (BMP-11) is a protein that in humans is ... GDF11 has pro-neurogenic, pro-angiogenic properties, induces CNS patterning and has been proposed as a "rejuvenating factor"[8] ... Signaling peptide/protein receptor modulators. Growth factor receptor modulators. Cytokine receptor modulators. ... GO:0001948 protein binding. Cellular component. • intracellular membrane-bounded organelle. • nucleoplasm. • extracellular ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... These proteins interact with a conserved family of cell surface serine/threonine-specific protein kinase receptors, and ... Signaling peptide/protein receptor modulators. Growth factor receptor modulators. Cytokine receptor modulators. ... Human genes encoding proteins that contain this domain include:. AMH; ARTN; BMP10; BMP15; BMP2; BMP3; BMP4; BMP5; BMP6; BMP7; ...
Fibrin and fibronectin cross-link together and form a plug that traps proteins and particles and prevents further blood loss.[ ... Endothelial cells are attracted to the wound area by fibronectin found on the fibrin scab and chemotactically by angiogenic ... Bartkova J, Grøn B, Dabelsteen E, Bartek J (February 2003). "Cell-cycle regulatory proteins in human wound healing". Archives ... Keratinocytes themselves also produce and secrete factors, including growth factors and basement membrane proteins, which aid ...
April 2003). "Enhancement of therapeutic protein in vivo activities through glycoengineering". Nature Biotechnology. 21 (4): ... raising concern that the angiogenic actions of erythropoietin may exacerbate retinopathy.[14][needs update][15] Since anemia ...
Angiogenic proteins such as vascular endothelial growth factor (VEGF) and placental growth factor (PIGF) and anti-angiogenic ... Proteinuria ≥ 0.3 grams (300 mg) or more of protein in a 24-hour urine sample or a SPOT urinary protein to creatinine ratio ≥ ... sFlt-1 is an anti-angiogenic protein that antagonizes vascular endothelial growth factor (VEGF) and placental growth factor ( ... yielding a state of hypoxia and increased oxidative stress and the release of anti-angiogenic proteins along with inflammatory ...
By degrading these proteins, cancer cells are able to breach the ECM and escape. The location of the metastases is not always ... "Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis" (PDF). Science. 319 (5860): 195-8. ... To do so, malignant cells break away from the primary tumor and attach to and degrade proteins that make up the surrounding ... The body resists metastasis by a variety of mechanisms through the actions of a class of proteins known as metastasis ...
If the number of cells still proliferating is balanced by the number dying from no blood supply, the tumor sits in angiogenic ... Aguirre-Ghiso J. A., Ossowski L., and Rosenbaum, S.K. (2004). Green fluorescent protein tagging of extracellular signal- ... Naumov G.N., Akslen L.A., and Folkman J. (2006). Role of angiogenesis in human tumor dormancy: animal models of the angiogenic ... Tumor mass dormancy is also often associated with angiogenic dormancy. This occurs when tumors enter a hypoxic state because ...
HACE1: HECT domain and Ankyrin repeat containing, E3 ubiquitin protein ligase 1 (6q21) ... VEGF: vascular endothelial growth factor A (angiogenic growth factor). *IGF2R: insulin-like growth factor 2 receptor ...
Fetal liver kinase-1 (Flk-1) is a cell surface receptor protein that is commonly used as a marker for ESCs and EPCs. CD34 is ... This is because some of the differentiated cells may just have angiogenic properties. Studies have shown that when vascular ... preconditioning of angiogenic cells by volatile anesthetics". Anesthesia & Analgesia. 109 (4): 1117-26. doi:10.1213/ane. ...
Numerous clinical trials were performed, either applying protein (angiogenic growth factor) therapies, such as FGF-1 or VEGF, ... High levels of lipoprotein(a),[39][40][41] a compound formed when LDL cholesterol combines with a protein known as ... Research efforts are focused on new angiogenic treatment modalities and various (adult) stem-cell therapies. A region on ... "Angiogenesis Protein Therapy With Human Fibroblast Growth Factor (FGF-1) Results of a Phase I Open Label, Dose Escalation ...
蛋白質(英語:Template:Angiogenic proteins). 疾病. *先天(英語:Template:Congenital vascular defects) ...
These proteins had a high degree of amino acid identity but were determined to be distinct proteins. ... Right, analysis quantifying the angiogenic effect.[22]. While many FGFs can be secreted by cells to act on distant targets, ... The fibroblast growth factors (FGF) are a family of cell signalling proteins that are involved in a wide variety of processes, ... FGFs are multifunctional proteins with a wide variety of effects; they are most commonly mitogens but also have regulatory, ...
... M. J. Koss, M. Pfister, and F. H. ... M. J. Koss, M. Pfister, and F. H. Koch, "Inflammatory and Angiogenic Protein Detection in the Human Vitreous: Cytometric Bead ...
Developmental Endothelial Locus-1 (Del-1), a Novel Angiogenic Protein. Its Role in Ischemia. Hoai-Ky V. Ho, James J. Jang, ... Mutation of the RGD to RAD sequence reduces its angiogenic effect in the CAM assay to one third of that of the native protein. ... Developmental Endothelial Locus-1 (Del-1), a Novel Angiogenic Protein. Hoai-Ky V. Ho, James J. Jang, Shuichiro Kaji, Gary ... Developmental Endothelial Locus-1 (Del-1), a Novel Angiogenic Protein. Hoai-Ky V. Ho, James J. Jang, Shuichiro Kaji, Gary ...
A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.. Folkman J1, ... The sequestration of angiogenic endothelial mitogens in the basement membrane may be a general mechanism for regulating their ... The basement membranes of bovine cornea are found to contain an angiogenic endothelial cell mitogen, basic fibroblast growth ... These findings indicate that basement membranes of the cornea may serve as physiologic storage depots for an angiogenic ...
Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery (RAAPID-II). The safety and scientific validity of this ... 32 weeks in gestation in a woman with previously normal BP and proteinuria 0.3 grams in a 24-hour specimen or urine protein/ ...
Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery (RAAPID-II). This study has been completed. ...
Multiple pregnancies are thought to be associated with a high incidence of perinatal complications such as preterm labor, preeclampsia and low birth weight. But the true mechanisms of these obstetric complications are still uncertain. The components
Angiogenic protein expression in advanced epithelial ovarian cancer.. D P Barton, A Cai, K Wendt, M Young, A Gamero and S De ... Angiogenic protein expression in advanced epithelial ovarian cancer.. D P Barton, A Cai, K Wendt, M Young, A Gamero and S De ... Angiogenic protein expression in advanced epithelial ovarian cancer.. D P Barton, A Cai, K Wendt, M Young, A Gamero and S De ... Angiogenic protein expression in advanced epithelial ovarian cancer. Message Subject (Your Name) has forwarded a page to you ...
Protein. Similar proteins. Species. Score. Length. Source. Q8N302. Angiogenic factor with G patch and FHA domains 1, isoform ... Protein. Similar proteins. Species. Score. Length. Source. Q8N302. Angiogenic factor with G patch and FHA domains 1, isoform ... Protein. Similar proteins. Species. Score. Length. Source. Q8N302. Angiogenic factor with G patch and FHA domains 1, isoform ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ...
... protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions ... 3-1. aMTD/SD-Fused SOC53 Recombinant Proteins Are Cell-Permeable To examine protein uptake, SOCS3 recombinant proteins were ... Development of Protein-Based Biotherapeutics That Penetrates Cell-Membrane and Induces Anti-Angiogenic Effect - Improved Cell- ... In the present art, iCP-SOCS3 proteins have been tested for use as anti-angiogenic agents. Since SOCS3 is known to be an ...
Plasmalemma Vesicle-Associated Protein Promotes Angiogenesis by Stimulation of the Endothelial Production of Pro-Angiogenic ... Plasmalemma Vesicle-Associated Protein Promotes Angiogenesis by Stimulation of the Endothelial Production of Pro-Angiogenic ... Plasmalemma Vesicle-Associated Protein Promotes Angiogenesis by Stimulation of the Endothelial Production of Pro-Angiogenic ... Plasmalemma Vesicle-Associated Protein Promotes Angiogenesis by Stimulation of the Endothelial Production of Pro-Angiogenic ...
The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway. Yugang Wang, ... The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway ... The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway ... The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway ...
Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity. SS Tolsma, OV ... Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity ... The definition of short peptides from each of these domains that are able to block the angiogenic process may be of use in ... The majority of the anti-angiogenic activity of TSP1 resides in the central 70-kD stalk region which alone could block ...
In this study, the anti-angiogenic features of one of these genes (angiopoietin like protein 7; angptl7) were examined in vitro ... Angiopoietin like protein 7 is a novel anti-angiogenic molecule expressed in cornea ... Angiopoietin like protein 7 is a novel anti-angiogenic molecule expressed in cornea ... Angiopoietin like protein 7 is a novel anti-angiogenic molecule expressed in cornea. Invest. Ophthalmol. Vis. Sci. 2014;55(13): ...
An in Vivo Function for the Transforming Myc Protein: Elicitation of the Angiogenic Phenotype. 1 Cam V. Ngo, Michael Gee, Nasim ... Genomic targets of the human c-Myc protein. Genes & Dev., May 1, 2003; 17(9): 1115 - 1129. [Abstract] [Full Text] [PDF] ... These data suggest that Myc is fully competent to trigger the angiogenic switch in vivo and that secondary events may not be ... The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes & Dev., September 15, 2006; 20(18): 2527 ...
Magnetic Resonance and Fluorescence-Protein Imaging of the Anti-angiogenic and Anti-tumor Efficacy of Selenium in an Orthotopic ... Magnetic Resonance and Fluorescence-Protein Imaging of the Anti-angiogenic and Anti-tumor Efficacy of Selenium in an Orthotopic ... Magnetic Resonance and Fluorescence-Protein Imaging of the Anti-angiogenic and Anti-tumor Efficacy of Selenium in an Orthotopic ... Magnetic Resonance and Fluorescence-Protein Imaging of the Anti-angiogenic and Anti-tumor Efficacy of Selenium in an Orthotopic ...
G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion. ... Akt-cAMP response element binding protein (CREB) pathway, which led to decreased production of the pro-angiogenic mediator ... G-protein-coupled receptor 81 (GPR81) functions as a receptor for lactate and plays an important role in the regulation of anti ...
Plasma angiogenic proteins were evaluated as potential PD biomarkers of response to lenvatinib in a dose-escalation phase 1 ... PD biomarker changes observed in plasma angiogenic proteins are correlated with lenvatinib-induced tumor shrinkage and AEs. Our ... Blood samples for plasma proteins were collected on days 1 (baseline), 8, and 15 of cycle 1, and days 1, 8, and 15 of cycle 2. ... findings warrant further assessment of plasma proteins associated with angiogenesis as potential biomarkers of lenvatinib ...
... including a switch to the angiogenic phenotype (i.e., initial recruitment of blood vessels). Failure of a microscopic tumor to ... Angiogenic Proteins / metabolism* * Animals * Antineoplastic Agents / pharmacology * Biomarkers, Tumor / metabolism* * Cell ... mechanisms involved in the angiogenic switch and different strategies for isolation of both angiogenic and non-angiogenic tumor ... Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch Cell Cycle. 2006 Aug;5(16):1779-87. doi: ...
... an endogenous ligand for the orphan G-protein-coupled receptor APJ, in cardiovascular and central nervous systems. We report a ... new function of apelin as a novel angiogenic factor in retinal endothelial cells. The retinal endothe … ... Apelin is a novel angiogenic factor in retinal endothelial cells Biochem Biophys Res Commun. 2004 Dec 10;325(2):395-400. doi: ... There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled ...
Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61), Cat#RPU41118. Write a Review Write a Review. × ... Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61), Cat#RPU41118. Rating Required Select Rating. 1 star (worst). ... Cysteine Rich Protein, Angiogenic Inducer 61. Alternative Names. CCN1; GIG1; IGFBP10; CCN family member 1; Insulin-like growth ... Human eosinophil cationic protein, ECP ELISA Kit, Cat#EKC33579 Quick view Wishlist ...
Our findings denote for the first time distinct angiogenic subtypes of human glioblastoma which may prove relevant for anti- ... patterns in primary glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins. ... No data exist on angiogenic patterns and their prognostic impact in human glioblastoma. Such data are relevant for translation ... Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: ...
Smith, J. R., David, L., Appukuttan, B., & Wilmarth, P. (Accepted/In press). Angiogenic and Immunologic Proteins Identified by ... Smith, JR, David, L, Appukuttan, B & Wilmarth, P 2018, Angiogenic and Immunologic Proteins Identified by Deep Proteomic ... Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial ... Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial ...
Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Porcine Cyr61 (Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit » Porcine Cyr61 (Cysteine Rich Protein, Angiogenic ... Porcine Cyr61 (Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit. Porcine Cyr61 (Cysteine Rich Protein, Angiogenic ... Porcine Cyr61 (Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit. Porcine Cyr61 (Cysteine Rich Protein, Angiogenic ...
The pro-angiogenic property may contribute to the beneficial effects reported after treatment of chronic ulcers with the novel ... Porcine serum albumin was used as control for unspecific protein effects. The plates were incubated at 37°C and sprouting was ... This result is comparable to the positive control, fibronectin, an ECM protein involved in all phases of tissue repair. Taken ... Amelogenin is an extracellular matrix protein that has been reported to promote formation of granulation tissue and repair of ...
Shear-Sensitive Angiogenic Genes and Proteins. To identify the genes and the secreted proteins that are responsible for shear- ... Angiopoietin-2 (Ang2), a known angiogenic protein, was found to be downregulated by LS both in cultured ECs and mouse aortas. ... To examine this hypothesis, we carried out gene array and protein array studies specific for angiogenic factors and cytokines, ... mediated tubule formation and migration, we performed a gene array containing 128 human angiogenic genes and a protein array of ...
Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor ... Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor ... Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor ... Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor ...
3.2 Momordica charantia extracts increase the phosphorylation of angiogenic signaling protein ERK1/2. Because the activation of ... This hypothesis was verified based on the induced phosphorylation of angiogenic signaling protein ERK1/2 and on tube formation ... The protein concentration in each sample was determined using a Bio-Rad protein assay. The volume of each sample containing 20 ... Thus, MC extracts exert direct pro-angiogenic signaling mediated via RAGE to overcome the anti-angiogenic effects of high BSA- ...
Microparticles harboring Sonic Hedgehog promote angiogenesis through the up-regulation of adhesion proteins and pro-angiogenic ... Microparticles harboring Sonic Hedgehog promote angiogenesis through the up-regulation of adhesion proteins and pro-angiogenic ... Both cell adhesion and expression of proteins involved in this process such as Rho A and phosphorylation of focal-activated ... Both cell adhesion and expression of proteins involved in this process such as Rho A and phosphorylation of focal-activated ...
Angiogenic Proteins. Grant support. *2T32HL007950/HL/NHLBI NIH HHS/United States. *5K08HL093362/HL/NHLBI NIH HHS/United States ...
A panel of significant transcriptional alterations in angiogenic genes of 83 cancer samples was established by comparison to 30 ... Immunohistochemistry (IHC) was performed to trace the signalling cascade from gene to protein level. A distinctive expression ... A characteristic expression profile of angiogenic markers was established. The specific overexpression of EFNB2 in small ... From: Analysis of angiogenic markers in oral squamous cell carcinoma-gene and protein expression ...
  • Activation of cell survival pathways such as phosphoinositide-3-kinase/AKT/IKK or RAS/mitogen-activated protein kinase phosphorylates FOXOs at different sites which regulate FOXOs nuclear localization or degradation. (hindawi.com)
  • Mitogen-activated protein kinase (MAPK) pathway antagonists induce profound clinical responses in advanced cutaneous melanoma, but complete remissions are frustrated by the development of acquired resistance. (rupress.org)
  • Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). (bioportfolio.com)
  • Plasma angiogenic proteins were evaluated as potential PD biomarkers of response to lenvatinib in a dose-escalation phase 1 study. (semanticscholar.org)
  • and plasma angiogenic proteins, by enzyme linked immunosorbent assays. (biomedcentral.com)
  • Developmentally regulated endothelial cell locus-1 (Del-1), a 52-kDa extracellular matrix protein, is expressed by endothelial cells during embryological vascular development. (ahajournals.org)
  • Activation of α v β 3 receptors is required for vascular development and may be associated with a decrease in endothelial cell apoptosis and with downstream angiogenic signaling through protein kinases. (ahajournals.org)
  • 11,12 Del-1 has been shown to stimulate endothelial cell attachment and migration in vitro and promote angiogenic growth in the CAM assay. (ahajournals.org)
  • The basement membranes of bovine cornea are found to contain an angiogenic endothelial cell mitogen, basic fibroblast growth factor (FGF), as determined by heparin-affinity chromatography, immunoblotting, immunofluorescence, and stimulation of capillary endothelial cell proliferation. (nih.gov)
  • Proteins differentially expressed by these endothelial cell populations are potential drug targets. (elsevier.com)
  • Publicly available software packages were used to identify proteins that were differentially expressed between human retinal and choroidal endothelial cells, and to classify proteins that were highly abundant in each endothelial cell population. (elsevier.com)
  • T-CAM showed pronounced anti-angiogenic activities such as inhibition of endothelial cell tube formation, endothelial cell proliferation, and induction of endothelial cell apoptosis. (bvsalud.org)
  • Furthermore, using TaqMan Low-density Arrays we identified key pro-angiogenic genes induced by CRP among them were vascular endothelial cell growth factor receptor-2 (VEGFR2/KDR), platelet-derived growth factor (PDGF-BB), notch family transcription factors (Notch1 and Notch3), cysteine-rich angiogenic inducer 61 (CYR61/CCN1) and inhibitor of DNA binding/differentiation-1 (ID1). (biomedcentral.com)
  • Together these findings illustrate how the morphoregulatory protein, HOXA3 can facilitate tissue remodeling via coordinated changes in both epithelial and endothelial cell gene expression and behavior in adult tissues during wound repair. (biomedsearch.com)
  • The vascular endothelial growth factor (VEGF) family (notably VEGF-A and VEGF-C) are key angiogenic stimuli acting via endothelial cell-specific receptors, the VEGF receptor (VEGFR) tyrosine kinases ( 4 ). (aacrjournals.org)
  • We hypothesize that GD induces the angiogenic switch in tumors through activation of the unfolded protein response (UPR). (aacrjournals.org)
  • Because it is well established that tumor growth beyond the size of 1-2 mm is angiogenesis-dependent, we hypothesized that presentation of large tumors is attributed to a switch to the angiogenic phenotype in otherwise microscopic, dormant tumors. (nih.gov)
  • The development of animal models which recapitulate the clinically observed timing and proportion of dormant tumors which switch to the angiogenic phenotype are reviewed here. (nih.gov)
  • These models also allowed development of an angiogenesis-based panel of blood and urine biomarkers that can be quantified and used to detect microscopic tumors before or during the angiogenic switch. (nih.gov)
  • 2014. Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors. (uib.no)
  • Angiogenic cytokines produced in tumors via oncogene activation and/or hypoxia induce a mitogenic and motogenic phenotype in host endothelial cells ( 2 , 3 ). (aacrjournals.org)
  • By activating the angiogenic switch, tumors co-opt endothelial cells. (ewg.org)
  • First, how MDA-7 protein is regulated as tumors develop from benign moles to the full-blown skin cancer known as melanoma and secondly, how over-expression of the mda-7 gene will affect melanoma cancer cell growth. (bio-medicine.org)
  • In the scientific publication, the researchers conclude that the MDA-7 protein is present in normal melanocytes (cells responsible for pigmentation in the skin) and early stages of melanoma tumors. (bio-medicine.org)
  • An in Vivo Function for the Transforming Myc Protein: Elicitation of the Angiogenic Phenotype -- Ngo et al. (aacrjournals.org)
  • Tumor progression depends on sequential events, including a switch to the angiogenic phenotype (i.e., initial recruitment of blood vessels). (nih.gov)
  • We used deep proteomic profiling to define the molecular phenotype of human retinal and choroidal endothelial cells at the protein level. (elsevier.com)
  • To examine this hypothesis, we carried out gene array and protein array studies specific for angiogenic factors and cytokines, respectively. (ahajournals.org)
  • We find that HOXA3 gene expression is upregulated during wound healing in angiogenic endothelial cells and keratinocytes, and that HOXA3 is not induced in genetically diabetic mice that have impaired angiogenesis and wound repair. (biomedsearch.com)
  • Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene. (wikipedia.org)
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (wikipedia.org)
  • Here we explore a novel approach to neurotrophic factor-based therapy by engineering zinc finger protein transcription factors (ZFP TFs) that activate the expression of the endogenous glial cell line-derived neurotrophic factor (GDNF) gene. (jneurosci.org)
  • The therapeutic application of virus or proteins (angiogenic gene and protein therapies) as well as of stem and progenitor cells (cell-based therapies) have emerged as viable options to target particularly critical limb ischaemia in refractory cases. (escardio.org)
  • Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusion. (qxmd.com)
  • A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. (qxmd.com)
  • We set out to determine whether advanced epithelial ovarian cancer (EOC) is associated with elevated serum and ascitic concentrations of the angiogenic factors angiogenin (ANG), basic fibroblastic growth factor (bFGF), and vascular endothelial growth factor (VEGF), and whether the expression of angiogenic factors was associated with tumor vascularity. (aacrjournals.org)
  • Synovial concentrations of the angiogenic peptides bFGF and VEGF do not discriminate rheumatoid arthritis from other forms of inflammatory arthritis. (diva-portal.org)
  • Blood levels of specific angioregulatory miRs are not associated with levels of angiogenic proteins. (biomedcentral.com)
  • Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. (qxmd.com)
  • They conclude that the anti-angiogenic factors dominate the pro-angiogenic factors in PAD patients. (frontiersin.org)
  • 1 Hyperglycemia favors the formation of advanced glycation endproducts (AGEs) as a result of glycation of plasma proteins such as albumin, extracellular matrix proteins such as collagen, lipids or even of nucleic acids like DNA. (rsc.org)
  • Receptors, G-Protein-Coupled was added as new class to the Cell Surface Receptors. (nih.gov)
  • SU6668 inhibits the tyrosine kinase activity of three angiogenic receptors VEGFR2 (Flk-1/KDR), PDGFRβ, and FGFR1, which play a crucial role in tumor-induced vascularization. (aacrjournals.org)
  • These findings provide for the first time evidence that the caveolae-associated protein, PLVAP, functions as a regulator of angiogenesis by indirect stimulation of the production of the pro-angiogenic factor S1P via eEF1A1. (ahajournals.org)
  • Furthermore, the inhibition of GPR81 signaling suppressed angiogenesis through a phosphoinositide 3-OH kinase (PI3K)/Akt-cAMP response element binding protein (CREB) pathway, which led to decreased production of the pro-angiogenic mediator amphiregulin (AREG). (oncotarget.com)
  • Previously, recombinant proteins consisting of suppressor of cytokine signaling 3 (SOSC3) fused to the fibroblast growth factor (FGF) 4-derived MTM were developed to inhibit inflammation and apoptosis. (freepatentsonline.com)
  • Furthermore, solubilization domains (SDs) have been incorporated into the aMTD-fused SOCS3 recombinant proteins to enhance solubility with corresponding increases in protein yield and cell-/tissue-permeability. (freepatentsonline.com)
  • Previously developed SOCS3 recombinant proteins fused to MTM were only tested or used as anti-inflammatory agents to treat acute liver injury. (freepatentsonline.com)
  • cDNA microarray results showed that GD-induced UPR activation promoted upregulation of a number of proangiogenic mediators (VEGF, FGF-2, IL-6, etc.) and downregulation of several angiogenic inhibitors (THBS1, CXCL14, and CXCL10). (aacrjournals.org)
  • Changes in blood levels of, e . g ., vascular endothelial growth factor (VEGF), basic fibroblast growth factors (bFGF), and interleukin- (IL-) 8, have been observed in response to anti-angiogenic drugs. (biomedcentral.com)
  • The angiogenic response was abrogated by a neutralizing anti-VEGF antibody and mimicked by rVEGF. (elsevier.com)
  • Interestingly, VEGF induction by hypoxia was up-regulated in Jurkat T cells overexpressing the adaptor protein p66Shc but not the inactive S36 p66Shc mutant, and it was abolished in p66Shc-/- mouse splenocytes. (elsevier.com)
  • Angiogenesis was determined in reconstituted basement membrane protein (matrigel) plugs containing vascular endothelial growth factor (VEGF) implanted into nondiabetic or insulin-deficient diabetic wild-type or RAGE −/− mice. (diabetesjournals.org)
  • Mechanistically, we report that CAF-CD38 drives the protein expression of an angiogenic/pro-metastatic signature, which includes VEGF-A, FGF-2, CXCL-12, MMP-9, and HGF. (nature.com)
  • Of the ten angiogenic proteins studied, only four - VEGF, PDGF-BB, ANG-2, and Angiogenin - were detectable in cell supernatant in any of the study conditions. (arvojournals.org)
  • These signals include growth factors, which I described previously, the primary angiogenic growth factor being Vascular Endothelial Growth Factor (VEGF) . (ewg.org)
  • The definition of short peptides from each of these domains that are able to block the angiogenic process may be of use in designing targeted inhibitors of the pathological neovascularization that underlies many diseases. (rupress.org)
  • Amino Acids, Peptides and Proteins (D12): 246 new descriptors were added. (nih.gov)
  • Results: Human retinal and/or choroidal vascular endothelial cells expressed 5042 nonredundant proteins. (elsevier.com)
  • Smith, JR , David, L , Appukuttan, B & Wilmarth, P 2018, ' Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs ' American Journal of Ophthalmology . (elsevier.com)
  • Endogenous Del-1 protein expression was increased in ischemic hindlimbs. (ahajournals.org)
  • Since SOCS3 is known to be an endogenous inhibitor of pathological angiogenesis, we reasoned that iCP-SOCS3 could be used as a protein-based intracellular replacement therapy for inhibiting angiogenesis in tumor cells. (freepatentsonline.com)
  • There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled receptor APJ, in cardiovascular and central nervous systems. (nih.gov)
  • This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety of other chemicals and pharmaceutical agents. (bioportfolio.com)
  • Importantly, adenovirus-mediated overexpression of endogenous secretory RAGE, a decoy receptor for RAGE, restores diabetes-associated impairment of angiogenic response in vivo. (diabetesjournals.org)
  • Retinal and choroidal endothelial cells were enriched in angiogenic proteins, and retinal endothelial cells were also enriched in immunologic proteins. (elsevier.com)
  • This is the first report showing that apelin is an angiogenic factor in retinal endothelial cells. (nih.gov)
  • CCN proteins not only regulate crucial biological processes including cell differentiation, proliferation, adhesion, migration, apoptosis, ECM production, chondrogenesis and angiogenesis, but also have more sinister roles promoting conditions such as fibrogenesis. (biologists.org)
  • 14-17 Furthermore, exogenous administration of these growth factors is known to enhance the angiogenic response to ischemia. (ahajournals.org)
  • Physiologic and pathologic neovascularization in other tissues may also be initiated by release of stored angiogenic factors from the basement membrane. (nih.gov)
  • There was no correlation between the serum or ascitic concentrations of angiogenic factors and tumor vascularity. (aacrjournals.org)
  • Microparticles harboring Sonic Hedgehog promote angiogenesis through the up-regulation of adhesion proteins and pro-angiogenic factors. (unifg.it)
  • We demonstrate that MPsShh1 increase messenger RNA and protein levels of proangiogenic factors as measured by quantitative reverse transcription- polymerase chain reaction and western blot. (unifg.it)
  • In theses angiogenesis-dependent diseases the so-called angiogenic switch is "on" due to an imbalance of pro-angiogenic regulatory factors over anti-angiogenic ones [ 1 ]. (mdpi.com)
  • ref. 8 ) and matrix metalloproteinases (MMP), which degrade the extracellular matrix, release growth factors and cytokines, and allow directional migration toward angiogenic stimuli ( 9 ). (aacrjournals.org)
  • Initially, it was believed that these proteins were classical growth factors, and that simple application of recombinant material to cells was sufficient to recapitulate the entire range of CCN-dependent activities. (biologists.org)
  • Indeed, it is now established that the CCN proteins are not growth factors and thus should not be referred to as such. (biologists.org)
  • Our data suggests that NIC can regulate expression and secretion of angiogenic cytokines in ARPE-19 cells. (arvojournals.org)
  • Further study of its potential anti-angiogenic effects in neovascular eye disease should consider the differential regulation of some angiogenic cytokines during normoxia and hypoxia. (arvojournals.org)
  • Thus, we identify Hsp90 inhibitors as important regulators of many aspects of tumor angiogenesis (and potentially lymphangiogenesis) and suggest that they may provide therapeutic benefit not only via direct effects on tumor cells but also indirectly by inhibiting the production of angiogenic cytokines and responses of activated endothelial cells that contribute to tumor progression and metastasis. (aacrjournals.org)
  • Blood biomarkers are needed to monitor anti-angiogenic treatments for cancer. (biomedcentral.com)
  • 1990). To determine which of the structural motifs present in the 180-kD TSP1 polypeptide mediate the anti-angiogenic activity, a series of protease-generated fragments were tested using several in vitro and in vivo assays that reflect angiogenic activity. (rupress.org)
  • Angiostatic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Principally, it also couples with Gq proteins and might activate vasoconstrictive pathways under certain circumstances 8 , 9 . (ersjournals.com)
  • Chini EN, Chini CCS, Espindola Netto JM, de Oliveira GC, van Schooten W. The pharmacology of CD38/NADase: an emerging target in cancer and diseases of aging. (nature.com)
  • These findings indicate that basement membranes of the cornea may serve as physiologic storage depots for an angiogenic molecule. (nih.gov)
  • In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. (freepatentsonline.com)
  • We made fusion protein of fastatin and FIII 9-10, termed tetra-cell adhesion molecule (T-CAM) that can interact simultaneously with alphavbeta3 and alpha5beta1 integrins, both playing important roles in tumor angiogenesis. (bvsalud.org)
  • The anti-angiogenic and anti-tumoral activity of molecule like fastatin could be improved by fusing it with integrin-recognizing cell adhesion domain from other distinct proteins. (bvsalud.org)
  • Among a variety of AGE receptor or AGE-binding proteins that have been described, the receptor for AGEs (RAGE) is probably the best-characterized molecule. (diabetesjournals.org)
  • Ligation of RAGE in endothelial cells activates the transcription factor nuclear factor-κB (NF-κB), subsequently leading to increased expression of proatherogenic mediators, such as monocyte chemoattractant protein-1 or vascular cell adhesion molecule-1 ( 11 , 12 ). (diabetesjournals.org)
  • This graph shows the total number of publications written about "Angiostatic Proteins" by people in Harvard Catalyst Profiles by year, and whether "Angiostatic Proteins" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Angiostatic Proteins" by people in Profiles. (harvard.edu)
  • rmB7.2-IgG is a fusion protein of the extracellular domain of B7.2, and the hinge and constant domains of murine IgG2a. (aacrjournals.org)
  • Early anti-angiogenic proteins expression in amniotic fluid of twin fetuses. (biomedsearch.com)
  • Angiogenic protein expression in advanced epithelial ovarian cancer. (aacrjournals.org)
  • Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: evidence for distinct angiogenic subtypes. (ox.ac.uk)
  • Setting the differential expression false discovery rate at 0.05, 498 proteins of 3454 quantifiable proteins (14.4%) with minimum mean spectral counts of 2.5 were differentially abundant in the 2 cell populations. (elsevier.com)
  • Amelogenin is an extracellular matrix protein that has been reported to promote formation of granulation tissue and repair of chronic venous leg ulcers and elevate the pro-angiogenic vascular endothelial growth factor in dermal fibroblasts.1-3 This study investigated the effect of amelogenin on angiogenesis in an ex vivo sprouting assay and related the findings to the cell surface integrin expression. (chalmers.se)
  • Both cell adhesion and expression of proteins involved in this process such as Rho A and phosphorylation of focal-activated kinase were increased by MPsShh1, via a Rho-associated coiled-coil-containing protein kinase inhibitor-sensitive pathway. (unifg.it)
  • C-reactive protein (CRP) is an acute phase reactant whose expression in the vascular wall, in particular, in reactive plaque regions, and circulating levels increase in patients at high risk of cardiovascular events. (biomedcentral.com)
  • Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS. (bioportfolio.com)
  • The expression of this protein is inducible by TNF-alpha and IL-1 alpha. (wikipedia.org)
  • Fig. 6: CD38-dependent differential expression of angiogenic proteins and genes in MTAF cells. (nature.com)
  • Nicotinamide (NIC) has been shown to alter expression of some angiogenic proteins. (arvojournals.org)
  • 2018. SPEN protein expression and interactions with chromatin in mouse testicular cells. (uib.no)
  • 2016. Expression of Heat Shock Protein 27 in melanoma metastases is associated with overall response to bevacizumab monotherapy: Analyses of predictive markers in a clinical phase II study. (uib.no)
  • This study investigated the effects of Hsp90 inhibitors on client protein expression and key cellular functions required for tumor angiogenesis. (aacrjournals.org)
  • Indeed, a major difficulty in the CCN field has been the purification of active proteins, presumably because of the presence of repeated cysteine residues, which require the use of mammalian expression systems such as baculovirus or stable cell lines. (biologists.org)
  • This study revealed that Angptl7 acts as an anti-angiogenic factor in corneal angiogenesis in vitro and in vivo. (arvojournals.org)
  • Molecular chaperones, such as heat shock protein 90 (Hsp90), enable the correct folding, maturation, and subcellular localization of their client proteins, particularly under the stress conditions induced by hypoxia and nutrient deprivation frequently found in cancers ( 11 ). (aacrjournals.org)
  • HIF is a transcription factor, initiating the production of other proteins required to mediate the effects of hypoxia. (ewg.org)
  • A chromosomal fusion protein AML1/ETO can disrupt the corepressor complex leading to a derepression of Notch target genes. (uni-giessen.de)
  • In a previous study using protein microarrays, we have identified regulation of potentially proangiogenic proteins associated with haemorrhagic vessels in unstable plaques among them c-Jun N-terminal kinase (JNK) and c-src [ 10 ]. (biomedcentral.com)
  • Proteins that specifically inhibit the growth of new blood vessels (ANGIOGENESIS, PHYSIOLOGIC). (bioportfolio.com)
  • 2004) describing the dynamics of tumour, angiogenic proteins and effective vessels density. (aimsciences.org)
  • Our findings denote for the first time distinct angiogenic subtypes of human glioblastoma which may prove relevant for anti-angiogenic therapy approaches. (ox.ac.uk)
  • Our findings suggest that the changes previously observed in maternal serum hormones and angiogenic proteins level after anti-hypertensive treatment in PE could be due to a systemic effect of the drugs on maternal blood pressure and circulation rather than a direct effect of these drugs on placental biosynthesis and/or secretion. (qxmd.com)
  • Although many methods have been tested in preclinical and clinical studies, there are no established methods of serially monitoring patients receiving anti-angiogenic therapies. (biomedcentral.com)
  • and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. (drugs.com)
  • Vical's trivalent vaccine contains the H5 plasmid plus separate plasmids encoding consensus sequences of two highly conserved influenza virus proteins: nucleoprotein (NP) and ion channel protein (M2). (bio-medicine.org)
  • The strategy of combining two distinct anti-angiogenic molecules or cell adhesion domains could facilitate designing improved anticancer agent of therapeutic value. (bvsalud.org)
  • Although CCN family members were discovered over a decade ago, the precise biological role, mechanism of action and physiological function of these proteins has remained elusive until recently, when several key mechanistic insights into the CCN family emerged. (biologists.org)
  • There was no correlation between the angiogenic profile in serum and ascites and tumor vascularity. (aacrjournals.org)
  • Porcine serum albumin was used as control for unspecific protein effects. (chalmers.se)
  • No significant sprouting was observed with the non-specific protein control porcine serum albumin or medium only. (chalmers.se)
  • MC extracts or low concentrations of bovine serum albumin-derived AGEs (BSA-AGEs) stimulated proliferation, migration (using wound-healing assay) and tube formation (using Matrigel™-embedded 3D culture) of bovine aortic endothelial cells (BAEC) together with increases in the phosphorylation of extracellular signal-regulated kinase (ERK)1/2, the key angiogenic signaling cytoplasmic protein. (rsc.org)
  • Various cargo proteins fused to these CPPs have been used to test the functional and/or therapeutic efficacy of protein transduction. (freepatentsonline.com)
  • Accordingly, use of NIC may represent a therapeutic approach in AMD to alter angiogenic signaling. (arvojournals.org)
  • The therapeutic efficacy of combined antiangiogenic and immune therapy was tested against weakly immunogenic and highly metastatic 4T1 breast tumor using SU6668, an angiogenesis inhibitor and recombinant murine (rm) B7.2-IgG fusion protein, an immunostimulator. (aacrjournals.org)
  • The majority of the anti-angiogenic activity of TSP1 resides in the central 70-kD stalk region which alone could block neovascularization induced by bFGF in the rat cornea in vivo and inhibit both migration in a modified Boyden chamber and [3H]thymidine incorporation stimulated by bFGF in cultured capillary endothelial cells. (rupress.org)
  • Currently we know of dozens of proteins that induce or inhibit angiogensis through similar mechanisms. (ewg.org)
  • 2012. Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer. (uib.no)
  • The micro-environment affects the outcome of angiogenic responses in patients with diabetes mellitus. (rsc.org)
  • Vaxfectin® has demonstrated similar effect with protein-based vaccines, and the formulation can be adjusted to favor specific immune responses. (drugs.com)
  • It was designed primarily to elicit antibody responses against the H5 protein but could elicit T-cell responses against H5 as well. (bio-medicine.org)
  • The trivalent vaccine was designed to elicit a combination of T-cell and antibody responses against all three proteins. (bio-medicine.org)
  • Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory responses, processes known to be altered in preeclamptic pregnancies. (diva-portal.org)
  • However, this SOCS3 fusion proteins expressed in bacteria cells were hard to be purified in soluble form. (freepatentsonline.com)
  • inhibition of AGE formation in diabetic mice is shown to restore ischemia-induced angiogenesis in peripheral limbs ( 18 ), and AGEs inhibition with soluble RAGE can restore angiogenic potential during wound healing in diabetic mice ( 19 ). (diabetesjournals.org)
  • A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. (cancer.gov)
  • 2019. Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy. (uib.no)
  • In this report, fluorescent protein imaging (FPI) and magnetic resonance imaging (MRI) were utilized to demonstrate the effects of selenium on tumor progression and angiogenesis in an orthotopic model of human colon cancer. (iiarjournals.org)
  • G-protein-coupled receptor 81 (GPR81) functions as a receptor for lactate and plays an important role in the regulation of anti-lipolytic effects in adipocytes. (oncotarget.com)
  • Taken together, the present observations suggest that the angiogenic effects might be explained by the cell binding properties of amelogenin. (chalmers.se)
  • Blocking the receptor for AGEs (RAGE) inhibited low BSA-AGE- and MC extract-induced ERK1/2 phosphorylation and tube formation, indicating the crucial role of RAGE in the pro-angiogenic effects of MC extracts. (rsc.org)
  • Moreover, inhibitory effects of high BSA-AGE concentration on cell proliferation and migration were reduced by the addition of MC extracts, which reversed the BSA-AGE anti-angiogenic effect on tube formation. (rsc.org)
  • Thus, MC extracts exert direct pro-angiogenic signaling mediated via RAGE to overcome the anti-angiogenic effects of high BSA-AGEs, highlighting the biphasic RAGE-dependent mechanisms involved. (rsc.org)
  • This study enhances our understanding of the mechanisms underlying the pro-angiogenic effects of MC extracts in improvement of diabetes-impaired wound-healing. (rsc.org)
  • 11,12 Many studies have described both pro- and anti-angiogenic effects of AGEs, with effects that vary with the concentrations and types of AGEs. (rsc.org)
  • A number of drugs with anti-angiogenic effects are in common use to treat cancer, and a number are under investigation. (biomedcentral.com)
  • Milk contains at least three proteins for which modulatory effects on angiogenesis have been previously demonstrated. (mdpi.com)
  • Vaxfectin® has demonstrated similar effects with protein- and peptide-based vaccines in preclinical models. (drugs.com)
  • The IP receptor is coupled with Gs proteins and activates adenylate cyclase, leading to increased cyclic adenosine monophosphate levels in the target cells, which explains most of the biological effects. (ersjournals.com)
  • 0.05, n=8), thus indicating that PLVAP indeed regulates the production of pro-angiogenic S1P. (ahajournals.org)
  • 2017. Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma. (uib.no)
  • Previously developed hydrophobic CPPs-named membrane translocating sequence (MTS), membrane translocating motif (MTM) and macromolecule transduction domain (MTD)-are able to deliver biologically active proteins into a variety of cells and tissues. (freepatentsonline.com)
  • Background- Developmentally regulated endothelial locus-1 (Del-1) is an extracellular matrix protein that is expressed by endothelial cells during embryological vascular development. (ahajournals.org)
  • Protein transduction exploits the ability of some cell-penetrating peptide (CPP) sequences to enhance the uptake of proteins and other macromolecules by mammalian cells. (freepatentsonline.com)
  • Plasmalemma vesicle-associated protein (PLVAP) appeared to be specifically expressed in endothelial cells but its function in angiogenesis remains unknown. (ahajournals.org)
  • GEO (well-differentiated human colon carcinoma) cells transfected with green fluorescent protein (GFP) were implanted orthotopically into the colon of athymic nude mice. (iiarjournals.org)
  • The association of blood levels of microRNAs (miRs) implicated in angiogenesis with circulating endothelial cells (CEC) and with angiogenic proteins was examined in patients administered drugs with anti-angiogenic activity. (biomedcentral.com)
  • The supernatants of hypoxic T cells were highly angiogenic when delivered on the chick embryo CAM. (elsevier.com)
  • This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. (wikipedia.org)
  • Negative angiogenic signals include the prototypical thrombospondin-1 protein , which inhibits the growth and migration of endothelial cells. (ewg.org)
  • How do cancer cells activate the angiogenic switch? (ewg.org)
  • A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. (cancer.gov)
  • Upon subcutaneous administration, abaloparatide acts similar to PTHrP and targets, binds to and activates parathyroid hormone 1 (PTH1) receptor (PTH1R), a G protein-coupled receptor (GPCR) expressed in osteoblasts and bone stromal cells. (cancer.gov)
  • On the other hand, there is some scarce information on the potential of dietary lectins, edible plant proteins and high protein diets to modulate angiogenesis. (mdpi.com)
  • In vitro studies revealed that partially blocking UPR signaling by silencing protein kinase RNA-like ER kinase (PERK) or activating transcription factor 4 (ATF4) significantly reduced the production of angiogenesis mediators induced by GD. (aacrjournals.org)
  • Several studies have focused on known protein mediators of angiogenic processes. (biomedcentral.com)
  • Western blotting showed that CRP increased activation of early response kinase-1/2 (ERK1/2), a key protein involved in EC mitogenesis. (biomedcentral.com)