Angiogenic proteins. Medical search

Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.

A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It may play an important role in the development of branched CAPILLARIES during EMBRYOGENESIS.

Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.

A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.

A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.

These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.

Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.

Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.

A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.

A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.

An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.

Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)

Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. (1/368)

Angiogenesis is required for the growth and progression of malignancies. Recent studies have demonstrated that genetic alterations may accompany acquisition of the angiogenic phenotype. The tumor suppressor gene p53 is most frequently mutated in human cancers and is also known to be a transcriptional regulator of a variety of genes. Here, we investigated the antiangiogenic effect of the wild-type p53 (wt-p53) gene transfer on a human non-small cell lung cancer cell line. Mutant p53-expressing H226Br non-small cell lung cancer cells were transduced with the wt-p53 gene using a recombinant adenoviral vector (Ad5CMVp53) and applied to semiquantitative reverse transcription-PCRs for the detection of altered mRNA expression of angiogenic and/or antiangiogenic factors. In vivo neovascularization assay of Ad5CMVp53-infected cells was then performed using a membrane-diffusion chamber system s.c. transplanted in nu/nu mice. We also evaluated the effect of Ad5CMVp53-infected H226Br cells on nontransduced tumor cells in vivo by s.c. inoculating mixture of cells into nu/nu mice. Ad5CMVp53 infection markedly inhibited the expression of an angiogenic factor, vascular endothelial growth factor, and increased the expression of a novel antiangiogenic factor, brain-specific angiogenesis inhibitor 1, resulting in reduced neovascularization in vivo. Mixing experiments showed that tumor cells transduced with the wt-p53 gene inhibited the in vivo tumor growth of adjacent nontransduced cells. Our data suggest that a recombinant adenovirus expressing the wt-p53 gene is antiangiogenic, which may explain, in part, the mechanism of the bystander effect induced by the wt-p53 gene transfer on adjacent tumor cells. (+info)

Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: differential effect on proliferating endothelial cells. (2/368)

Vascular endothelial growth factor (VEGF) plays an important role in tumour angiogenesis. VEGF binds to tyrosine kinase receptors, which are expressed almost exclusively on tumour endothelium. Therefore, VEGF can be used to target toxin molecules to tumour vessels for anti-angiogenic therapy. However, recent evidence suggests that VEGF can also bind in an isoform-specific fashion to a newly identified neuropilin-1 (NP-1) receptor. NP-1 is widely expressed in normal tissue and presents a potential target for unwanted toxicity. As a consequence, we investigated whether the VEGF121 isoform, which lacks the NP-1 binding domain, could be used to target toxin polypeptides to tumour vasculature. Treatment of endothelial cells with a VEGF121-diphtheria toxin (DT385) conjugate selectively inhibited proliferating endothelial cells, whereas confluent cultures were completely resistant to the construct. In addition, VEGF121-DT385 conjugate treatment completely prevented tumour cell induced angiogenesis in vivo. Most importantly, the conjugate inhibited tumour growth in athymic mice and induced tumour-specific vascular damage. There was also no apparent toxicity associated with the treatment. Our results suggest that proliferating endothelial cells are highly sensitive to VEGF121-toxin conjugates and that the binding to NP-1 receptors is not necessary for efficient inhibition of tumour growth. (+info)

Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer. (3/368)

The expression of interleukin 10 (IL-10) is correlated with clinical prognosis in non-small cell lung cancer [NSCLC (H. Hatanaka et al., ANN: ONCOL:, 11: 815--819, 2000)]. However, the effects of IL-10 expression on vascularization in NSCLC are not apparent. We examined the gene expression of IL-10/IL-10 receptor and various angiogenic/angioinhibitory factors in 95 NSCLC samples to determine the correlation between IL-10 production and vascularization. Vascular endothelial growth factor, angiopoietin [Ang (Ang-1 and Ang-2)], thrombospondin, brain-specific angiogenesis inhibitor 1, vascular endothelial growth factor receptors (KDR and flt-1), and Ang receptor (TIE2) gene expression were evaluated by reverse transcription-PCR. The cellular localization of these factors and vascularity in the cancer stroma were examined immunohistochemically. Seventy-eight (82.1%) and 93 (97.9%) of these 95 NSCLCs were positive for IL-10 and IL-10 receptor, respectively. Ang-1, Ang-2, and TIE2 gene expression was seen in 76 (97.4%), 73 (93.6%), and 78 (100%) of 78 IL-10-positive NSCLCs, respectively, and was significantly correlated with IL-10 gene expression (P < 0.0088, <0.0008, and 0.0305, respectively; Fisher's exact method). The localizations of Ang-1, Ang-2, and TIE2 were confirmed within tumor cells immunohistochemically. Vascular number and measurement area were significantly higher in the IL-10-positive NSCLCs (33.500 +/- 9.299/microm(2) and 4.742 +/- 1.287%) as compared with IL-10-negative NSCLCs (10.611 +/- 2.839/microm(2) and 0.718 +/- 0.331%; Mann-Whitney U test, P = 0.0039). The IL-10 expression did not show any significant correlation with the expression of other factors. These results suggested that tumor-produced IL-10 promotes stromal vascularization through expression of Ang-1, Ang-2, and TIE2. (+info)

Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. (4/368)

The brain-specific angiogenesis inhibitor 1 gene has been isolated in an attempt to find fragments with p53 "functional" binding sites. As reported herein and by others, brain-specific angiogenesis inhibitor 1 expression is present in some normal tissues, but is reduced or lost in tumour tissues. Such data and its particular structure prompted the hypothesis that brain-specific angiogenesis inhibitor 1 may act as a mediator in the local angiogenesis balance. We herein demonstrate that brain-specific angiogenesis inhibitor 1 over-expression suppresses tumour angiogenesis, delaying significantly the human tumour growth in immunodeficient mice. The inhibitory effect of brain-specific angiogenesis inhibitor 1 was documented using our intravital microscopy system, strongly implicating brain-specific angiogenesis inhibitor 1 as a mediator in the control of tumour angiogenesis. In contrast, in vitro tumour cell proliferation was not inhibited by brain-specific angiogenesis inhibitor 1 transfection, whereas some level of cytotoxicity was assessed for endothelial cells. Immunohistochemical analysis of tumour samples confirmed a reduction in the microvessel density index in brain-specific angiogenesis inhibitor 1-overexpressing tumours. At messenger level, moderate changes could be detected, involving the down-regulation of vascular endothelial growth factor and collagenase-1 expression. Furthermore, brain-specific angiogenesis inhibitor 1 expression that was lost in a selection of human cancer cell lines could be restored by wild-type p53 adenoviral transfection. Brain-specific angiogenesis inhibitor 1 should be considered for gene therapy and development of efficient drugs based on endogenous antiangiogenic molecules. (+info)

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. (5/368)

PDZ domains typically interact with the very carboxyl terminus of their binding partners. Type 1 PDZ domains usually require valine, leucine, or isoleucine at the very COOH-terminal (P(0)) position, and serine or threonine 2 residues upstream at P(-2). We quantitatively defined the contributions of carboxyl-terminal residues to binding selectivity of the prototypic interactions of the PDZ domains of postsynaptic density protein 95 (PSD-95) and its homolog synapse-associated protein 90 (SAP102) with the NR2b subunit of the N-methyl-d-aspartate-type glutamate receptor. Our studies indicate that all of the last five residues of NR2b contribute to the binding selectivity. Prominent were a requirement for glutamate or glutamine at P(-3) and for valine at P(0) for high affinity binding and a preference for threonine over serine at P(-2), in the context of the last 11 residues of the NR2b COOH terminus. This analysis predicts a COOH-terminal (E/Q)(S/T)XV consensus sequence for the strongest binding to the first two PDZ domains of PSD-95 and SAP102. A search of the human genome sequences for proteins with a COOH-terminal (E/Q)(S/T)XV motif yielded 50 proteins, many of which have not been previously identified as PSD-95 or SAP102 binding partners. Two of these proteins, brain-specific angiogenesis inhibitor 1 and protein kinase Calpha, co-immunoprecipitated with PSD-95 and SAP102 from rat brain extracts. (+info)

Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (6/368)

Brain angiogenesis inhibitors (BAI) are putative transmembrane proteins containing an extracellular domain with thrombospondin type-1 repeats which can exhibit anti-angiogenic activity. BAI1 mRNA is expressed mainly in the brain, while BAI2 and BAI3 mRNAs are more widely expressed. We hypothesized that the BAI family might have anti-tumoral properties and studied the expression of BAI1 protein in normal human brain and in glioblastoma multiforme. We generated an anti-BAI1 antibody and showed that BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated. BAI1 expression did not correlate with TP53 status and we did not confirm previous findings that p53 regulates BAI1 mRNA expression in glioma cells. The finding that expression of BAI proteins may be lost during tumor formation is of special interest as restoration of their function in tumors may be of therapeutic benefit. (+info)

Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. (7/368)

Vascular endothelial growth factor (VEGF)-mediated angiogenesis is essential for bone formation. However, the effect of VEGF on osteoblastic cells during osteoblastogenesis is still controversial. The aim of this study was to clarify the relationship between osteoblastic cells derived from human mesenchymal stem cells (MSCs) and VEGF in the early stage of osteoblastic differentiation. Continuous dexamethasone treatment with a low concentration stimulated osteoblastogenesis of MSCs and the expression of VEGF121 mRNA. The VEGF secretion from osteoblastic cells also increased along with osteoblastogenesis. Neuropilin-1, which mainly binds VEGF165, was detected at all stages during early osteoblastogenesis, but VEGF receptor-1 and -2 were not detected on RT-PCR analyses. In this study, VEGF had no direct effect on the proliferation of osteoblastic cells. However, the secreted VEGF in the conditioned medium of osteoblastic cells exhibited high angiogenic power as to endothelial cell proliferation. Our findings indicated that VEGF121 principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. The present study also demonstrated the differential expression of VEGF121 during osteoblastogenesis. The increase of VEGF in the early stage might be a useful marker of induction of bone formation due to human MSCs. (+info)

Circulating proangiogenic cytokines and angiogenesis inhibitor endostatin in untreated patients with chronic lymphocytic leukemia. (8/368)

The serum concentration of two pro-angiogenic cytokines: basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF-beta1), and anti-angiogenic factor endostatin in the serum of 80 never treated B-cell chronic lymphocytic leukemia (CLL) patients and 27 healthy volunteers was measured using an enzyme linked immunosorbent assay. The serum levels of both bFGF and TGF-beta1 were found to be significantly higher in the CLL group (median 40.5 pg/ml and 38.6 ng/ml respectively) when compared to the control group (median 9.4 pg/ml and 18.9 ng/ml, respectively) (p<0.001). The levels of endostatin were not significantly different in CLL and control groups (median 12.3 ng/ml and 8.4 ng/ml, respectively) (p=0.09). In the group of CLL patients the level of bFGF was significantly higher in patients with progressive disease as compared with patients with stable disease (median 90.5 pg/ml and 40.5 pg/ml respectively) (p<0.001). Patients in Rai stage III and IV also had significantly higher levels of bFGF than patients in Rai stage 0-II (median 100.1 pg/ml and 29.3 pg/ml respectively) (p<0.001). The levels of both TGF-beta1 and endostatin were lower in patients in Rai stage III and IV (median 28.9 ng/ml and 9.1 ng/ml respectively) than in patients in Rai stage 0-II (42.8 ng/ml and 13.1 ng/ml respectively) (p<0.001 and p=0.002 respectively). The level of endostatin was also lower in the group of CLL patients with progressive disease (median 10.0 ng/ml) as compared to patients with stable disease (median 20.5 ng/ml) (p=0.008). In conclusion, the disturbance in the balance between pro- and anti-angiogenic factors may have an important influence on the course of CLL. (+info)

Pathologic neovascularization can be seen in a variety of conditions, including cancer, diabetic retinopathy, and age-related macular degeneration. In cancer, for example, the formation of new blood vessels can help the tumor grow and spread to other parts of the body. In diabetic retinopathy, the growth of new blood vessels in the retina can cause vision loss and other complications.

There are several different types of pathologic neovascularization, including:

* Angiosarcoma: a type of cancer that arises from the cells lining blood vessels
* Hemangiomas: benign tumors that are composed of blood vessels
* Cavernous malformations: abnormal collections of blood vessels in the brain or other parts of the body
* Pyogenic granulomas: inflammatory lesions that can form in response to trauma or infection.

The diagnosis of pathologic neovascularization is typically made through a combination of physical examination, imaging studies (such as ultrasound, CT scans, or MRI), and biopsy. Treatment options vary depending on the underlying cause of the condition, but may include medications, surgery, or radiation therapy.

In summary, pathologic neovascularization is a process that occurs in response to injury or disease, and it can lead to serious complications. It is important for healthcare professionals to be aware of this condition and its various forms in order to provide appropriate diagnosis and treatment.

... is protein that in humans is encoded by the TNFSF15 gene. VEGI is an anti-angiogenic protein. It belongs to tumor necrosis ... Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) ... This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this ... It is the sole known ligand for death receptor 3, and it can also be recognized by decoy receptor 3. The protein encoded by ...

https://en.wikipedia.org/wiki/Vascular_endothelial_growth_inhibitor

Circulating angiogenic proteins trisomy 12 Am J Obstet Gynecol. 2006 Jan:194(1):239-45 Sachs BP, A Woman with Fetal Loss - ... Circulating Angiogenic Factors and the Risk of Preeclampsia. NEJM 2004; 350:672-83 Levine RJ, Thadhani R, Qian C, Lam C, Lim KH ... a novel circulating anti-angiogenic factor in preeclampsia. N Engl J Med 2006;355:992-1005 Nielsen P, Goldman M, Mann S, ...

https://en.wikipedia.org/wiki/Benjamin_P._Sachs

January 1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-297. PMID 8570206. ... Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein is a transmembrane (type I) heparan sulfate ... The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and ... Indatuximab ravtansine targets this protein. It is a useful marker for plasma cells, but only if the cells tested are already ...

https://en.wikipedia.org/wiki/Syndecan_1

"HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Soussi-Yanicostas N, ... Syndecan-2 is a protein that in humans is encoded by the SDC2 gene. The protein encoded by this gene is a transmembrane (type I ... The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and ... Chang HC, Samaniego F, Nair BC, Buonaguro L, Ensoli B (1997). "HIV-1 Tat protein exits from cells via a leaderless secretory ...

https://en.wikipedia.org/wiki/Syndecan-2

... a unique angiopoietin-related protein with anti-angiogenic properties". Biochem. Biophys. Res. Commun. 333 (2): 308-15. doi: ... This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. GRCh38: Ensembl ... Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene ... 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein ...

https://en.wikipedia.org/wiki/Angiopoietin-related_protein_1

"HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Kojima T, Katsumi A, ... The protein is found as a homodimer and is a member of the syndecan proteoglycan family. Syndecan-4 interacts with ... Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has ... Syndecan-4 activates protein kinase C (PKC), an enzyme involved in signal transduction. The variable domain of syndecan-4 could ...

https://en.wikipedia.org/wiki/Syndecan-4

January 2000). "The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma". Journal of Leukocyte Biology. 67 (1 ... It was previously called GRO1 oncogene, GROα, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity ... this protein is encoded by the gene Cxcl1 and is located on human chromosome 4 among genes for other CXC chemokines. CXCL1 ... for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins ...

https://en.wikipedia.org/wiki/CXCL1

1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Chernousov MA, ... Hakansson S, Jacobs A, Caffrey M (2001). "Heparin binding by the HIV-1 tat protein transduction domain". Protein Sci. 10 (10): ... Syndecan-3 is a protein that in humans is encoded by the SDC3 gene. GRCh38: Ensembl release 89: ENSG00000162512 - Ensembl, May ... "Entrez Gene: SDC3 syndecan 3". Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency ...

https://en.wikipedia.org/wiki/Syndecan-3

... cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV. These proteins, ... is a novel angiogenic regulator of the CCN protein family". The Journal of Biological Chemistry. 278 (26): 24200-8. doi:10.1074 ... The human NOV protein contains 357 amino acids with an N-terminal secretory signal peptide followed by four structurally ... Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B (Feb 1999). "The C-terminal domain of the regulatory protein NOVH ...

https://en.wikipedia.org/wiki/NOV_(gene)

These gene products may include proteins such as glycolytic enzymes and angiogenic growth factors. In normoxia, HIF alpha ... 1996). "SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscle". Lab. Invest. 74 ( ... Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2), or prolyl hydroxylase domain-containing protein 2 (PHD2), is an enzyme ... 2006). "Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia- ...

https://en.wikipedia.org/wiki/EGLN1

The angiogenic switch downregulates angiogenesis suppressor proteins, such as thrombospondin, angiostatin, endostatin and ... GSCs are easily identified through histological staining against vasa protein (to identify germ cells) and 1B1 protein (to ... Angiogenesis induced by hypoxic conditions is called an "Angiogenic switch". HIF-1 promotes expression of several angiogenic ... The Bone Morphogenetic Protein (BMP) ligands Decapentaplegic (Dpp) and Glass-bottom-boat (Gbb) ligand are directly signalled to ...

https://en.wikipedia.org/wiki/Stem-cell_niche

... and anti-angiogenic effects. In biomarker studies, the protein has been found to have potential prognostic and diagnostic value ... "Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes". The ... The HRG protein is produced in the liver, and it could also be synthesized by monocytes, macrophages, and megakaryocytes. It ... Two of the protein's effects, the inhibition of fibrinolysis and the reduced inhibition of coagulation, indicate a potential ...

https://en.wikipedia.org/wiki/Histidine-rich_glycoprotein

2015-01-26). "Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea". PLOS ONE. ... TMEM155 protein is 130 amino acids in length. The TMEM155 protein in its full form is 14.2 kD in molecular weight with an ... Transmembrane protein 155 is a protein that in humans is encoded by the TMEM155 gene. It is located on human chromosome 4, ... This protein is known to be expressed mainly in the brain, placenta, and lymph nodes and is conserved throughout most placental ...

https://en.wikipedia.org/wiki/TMEM155

"Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity". The Journal ... This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to ... "Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell ... the remaining anti-angiogenic domains have been shown to have decreased anti-angiogenic activity at low concentrations where ...

https://en.wikipedia.org/wiki/Thrombospondin_1

Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M (April 2009). "Mitogen-activated protein 3 kinase 6 mediates angiogenic and ... Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene. This gene encodes a ... "Entrez Gene: Mitogen-activated protein kinase kinase kinase 6". Retrieved 2018-07-10. Takeda K, Shimozono R, Noguchi T, Umeda T ... serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded ...

https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase_6

... an angiogenic protein, at 2.0 A resolution". The Journal of Biological Chemistry. 276 (15): 12153-61. doi:10.1074/jbc. ... There are three isoforms of this protein: PGF-1, PGF-2, PGF-3. PGF-1 is specifically found in the colon as well as mammary ... Placental growth factor (PlGF) is a protein that in humans is encoded by the PGF gene. Placental growth factor (PGF) is a ... The placental growth factor (PGF) gene is a protein-coding gene and a member of the vascular endothelial growth factor (VEGF) ...

https://en.wikipedia.org/wiki/Placental_growth_factor

"Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and ... The protein content of a single exosome, given certain assumptions of protein size and configuration, and packing parameters, ... Exosomes contain RNA, proteins, lipids and metabolites that is reflective of the cell type of origin. As exosomes contain ... The Rab proteins especially Rab 7 attached to the MVB recognizes its effector receptor. The SNARE complex (soluble N- ...

https://en.wikipedia.org/wiki/Exosome_(vesicle)

"Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1". ... This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins belong to the alpha-ketoglutarate- ... They are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative ... "Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1". ...

https://en.wikipedia.org/wiki/JMJD6

This protection appears to be due to the elevated levels of endostatin, an anti-angiogenic protein, derived from collagen XVIII ... An experimental study suggests that pericyte death is caused by blood glucose persistently activating protein kinase C and ... mitogen-activated protein kinase (MAPK), which, through a series of intermediates, inhibits signaling through platelet-derived ...

https://en.wikipedia.org/wiki/Diabetic_retinopathy

December 2010). "CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic ... Silmitasertib (INN), codenamed CX-4945, is a small-molecule inhibitor of protein kinase CK2 (casein kinase II), a ... Protein kinase inhibitors, Carboxylic acids, Chloroarenes, All stub articles, Antineoplastic and immunomodulating drug stubs). ... the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer". Journal of Medicinal Chemistry. 54 (2): ...

https://en.wikipedia.org/wiki/Silmitasertib

Nam, J. O.; Jung, M. Y.; Thapa, N.; Lee, B. H.; Park, R. W.; Kim, I. S. (2008). "T-CAM, a fastatin-FIII 9-10 fusion protein, ... potently enhances anti-angiogenic and anti-tumor activity αvβ3 and α5β1 integrins". Experimental & Molecular Medicine. 40 (2): ... Nam, J. -O.; Son, H. -N.; Jun, E.; Cha, K.; Lee, B. -H.; Park, R. -W.; Kim, I. -S. (2012). "FAS1 Domain Protein Inhibits ... Thapa, N.; Lee, B. H.; Kim, I. S. (2007). "TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β". The ...

https://en.wikipedia.org/wiki/Lee_Byung-heon_(biochemist)

... pro-angiogenic protein therapy uses well-defined, precisely structured proteins, with previously defined optimal doses of the ... which angiogenic research began with, and pro-angiogenic therapies. Whereas anti-angiogenic therapies are being employed to ... Chemical stimulation of angiogenesis is performed by various angiogenic proteins e.g. integrins and prostaglandins, including ... As part of the angiogenic signaling cascade, NO is widely considered to be a major contributor to the angiogenic response ...

https://en.wikipedia.org/wiki/Angiogenesis

These effects are mediated by interacting and interfering with various angiogenic related proteins such as integrins and serine ... "Structure-function analysis of the ADAM family of diintegrin-like and metalloproteinase-containing proteins". J. Protein Chem. ... Native proteins which contain such domains with regulatory activity are normally inactive, most likely because they are cryptic ... Monocytes produce a variety of pro-angiogenic factors. There is also a population of CD34 positive cells that can express ...

https://en.wikipedia.org/wiki/Proteases_in_angiogenesis

Slevin M, Krupinski J, Kumar S, Gaffney J (August 1998). "Angiogenic oligosaccharides of hyaluronan induce protein tyrosine ... HYAL1 is implicated in several types of cancers, likely due to the angiogenic effects of HYAL1-cleaved hyaluronan fragments. In ...

https://en.wikipedia.org/wiki/HYAL1

... includes proteins that are angiogenic factors. The presence of the cyclic cystine knot (CCK) motif was discovered when ... Novel proteins are being added to the cystine knot motif family, also known as the C-terminal cystine knot (CTCK) proteins. ... The cystine knot motif stabilizes protein structure and is conserved in proteins across various species. There are three types ... Studies have shown that cystine knot proteins can be incubated at temperatures of 65 °C or placed in 1N HCl/1N NaOH without ...

https://en.wikipedia.org/wiki/Cystine_knot

Studies have shown that proteins found in tight junctions serve as intermediaries that moderate angiogenic signaling pathways. ... They interact in their cytoplasmic domain with scaffold proteins that contain a PDZ domain, which are common protein ... Like JAM-2, JAM-3 has been shown associate with tight junction proteins like PAR-3 and ZO-1. JAM-3 has also been shown to ... Once the tight junction is formed, many JAM-1 proteins are present, many of which are now phosphorylated at Ser285. JAM-1 also ...

https://en.wikipedia.org/wiki/Junctional_adhesion_molecule

1997). "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer". Nat. Med. 3 (10): 1137-40. doi: ... 2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated ... Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. FGFBP1, or HBP17, binds ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ...

https://en.wikipedia.org/wiki/FGFBP1

Angiogenic proteins such as vascular endothelial growth factor (VEGF) and placental growth factor (PIGF) and anti-angiogenic ... sFlt-1 is an anti-angiogenic protein that antagonizes vascular endothelial growth factor (VEGF) and placental growth factor ( ... Proteinuria ≥ 0.3 grams (300 mg) or more of protein in a 24-hour urine sample or a SPOT urinary protein to creatinine ratio ≥ ... Implicit in this generalized endothelial dysfunction may be an imbalance of angiogenic and anti-angiogenic factors. Both ...

https://en.wikipedia.org/wiki/Pre-eclampsia

... is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functions. Found in ... The PEDF protein is a secreted protein of roughly 50kDa size and 418 amino acids in length. The N-terminus contains a leader ... They isolated proteins unique to RPE cells and tested the individual proteins for neurotrophic function, meaning promoting a ... This discovery demonstrated that PEDF has an asymmetrical charge distribution across the whole protein. One side of the protein ...

https://en.wikipedia.org/wiki/PEDF

2003). "The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through ... Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. It belongs to the ... Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to ... 1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc ...

https://en.wikipedia.org/wiki/GBP1

Zan L, Zhang X, Xi Y, Wu H, Song Y, Teng G, Li H, Qi J, Wang J (2013). "Src regulates angiogenic factors and vascular ... c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein ... Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc ... Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H (May 1991). "Cloning of a complementary DNA for a protein-tyrosine kinase ...

https://en.wikipedia.org/wiki/Proto-oncogene_tyrosine-protein_kinase_Src

Some viruses can encode proteins that bind to double-stranded RNA (dsRNA) to prevent the activity of RNA-dependent protein ... Interferons can also suppress angiogenesis by down regulation of angiogenic stimuli deriving from tumor cells. They also ... the E7 protein of Human papillomavirus (HPV), and the B18R protein of vaccinia virus. Reducing IFN-α activity may prevent ... phosphorylates ribosomal protein s6, which is involved in protein synthesis; and phosphorylates a translational repressor ...

https://en.wikipedia.org/wiki/Interferon

The primary pathology is in the placenta, which secretes an anti-angiogenic factor in response to ischaemia, leading to ... Aberrant steroid hormone-dependent regulation of neuronal calcium influx via extracellular matrix proteins and membrane ...

https://en.wikipedia.org/wiki/Postpartum_psychosis

Lazarovici also contributed to the characterization of NGF angiogenic properties and characterization of human umbilical cord ... Involvement of Mitogen-Activated Protein Kinases and Gene Expression". Annals of the New York Academy of Sciences. 1053 (1): 84 ...

https://en.wikipedia.org/wiki/Philip_Lazarovici

TGF-𝝱 works by binding to cell-surface receptors and activating the Smad gene regulatory proteins. Smad proteins then trigger ... "Vascular Endothelial Growth Factor is a Secreted Angiogenic Mitogen". 8 December 1989, Science, Vol. 246, pp 1306-1309. Morgan ... One of the most important of these is TP53, a gene which produces a family of proteins known as p53. It, combined with the Ras ... The protein kinase domain found on mitogenic receptors is often hyperactivated in cancer cells, remaining turned on even in the ...

https://en.wikipedia.org/wiki/Mitogen

... an immunomodulatory protein that promotes tumor development, influences suppressive and pro-angiogenic cells in the tumor ... Tasquinimod reduces tumor angiogenesis; but its anti-angiogenic effects do not appear to be linked to vascular endothelial ... pro-angiogenic and pro-metastatic functions of regulatory myeloid cells (also called myeloid-derived suppressor cells). It ...

https://en.wikipedia.org/wiki/Tasquinimod

Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene. The protein encoded by this gene is a member of the ... 2001). "Involvement of alpha3 integrin/tetraspanin complexes in the angiogenic response induced by angiotensin II". FASEB J. 15 ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to ...

https://en.wikipedia.org/wiki/TSPAN7

... encoding protein Unc-5 homolog C (C. elegans)-like VEGF: vascular endothelial growth factor A (angiogenic growth factor) ( ... encoding protein Absent in melanoma 1 protein (6q21) AIG1: encoding protein Androgen-induced protein 1 (6q24.2) AKIRIN2: akirin ... tight junction associated protein 1 (6p21.1) TP53COR1 encoding protein Tumor protein p53 pathway corepressor 1 (non-protein ... F-box protein 9 (6p12.1) FOXP4-AS1: encoding protein FOXP4 antisense RNA 1 FTH1P5: encoding protein Ferritin, heavy polypeptide ...

https://en.wikipedia.org/wiki/Chromosome_6

VEGF-A protein production is reduced as mir-126 binds to the 3' untranslated region of the VEGF-A mRNA. IRS-1 inhibiting the ... "miR-126 regulates angiogenic signaling and vascular integrity". Dev Cell. 15 (2): 272-84. doi:10.1016/j.devcel.2008.07.008. PMC ... CRK, a protein involved in intracellular signal pathways involved in regulating cellular adhesion, proliferation, migration and ... binds to a complementary sequence within EGFL7 preventing translation of the mRNA resulting in a decrease of EGFL7 protein ...

https://en.wikipedia.org/wiki/Mir-126

engineered a mutation of a protein suspected to participate in the regulation of Gal genes. This mutation was hypothesized to ... November 2002). "A reverse transcription comparative real-time PCR method for quantitative detection of angiogenic growth ... When these genes are expressed in prokaryotic cells for the sake of protein production or purification, the RNA produced ... The researchers were able to conclusively determine that the mutation of this regulatory protein reduced Gal expression. ...

https://en.wikipedia.org/wiki/Reverse_transcription_polymerase_chain_reaction

The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct ... based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of ... Though originally treated as separate proteins, cloning technology demonstrated that GPI is almost identical to the protein ... Protein pages needing a picture, Genes on human chromosome 19, Protein domains, EC 5.3.1, Tumor markers, Glycolysis enzymes, ...

https://en.wikipedia.org/wiki/Glucose-6-phosphate_isomerase

Lenvatinib in combination with everolimus was approved in 2016 for patients who have had exactly one prior line of angiogenic ... Non-endocrine dysfunctions include deposition of protein in tissue (amyloidosis), decrease in hemoglobin or red blood cells ( ...

https://en.wikipedia.org/wiki/Kidney_cancer

... binding protein], PACT (protein activator of the interferon-induced protein kinase), the SMN complex, fragile X mental ... mediating pro-inflammatory and pro-angiogenic signals. These findings were observed in ligated carotid arteries of mice to ... HMGA proteins (HMGA1a, HMGA1b and HMGA2) are implicated in cancer, and expression of these proteins is regulated by microRNAs. ... HMGA2 protein specifically targets the promoter of ERCC1, thus reducing expression of this DNA repair gene. ERCC1 protein ...

https://en.wikipedia.org/wiki/MicroRNA

... specifically binds to the 165 isoform of VEGF, a protein that plays a critical role in angiogenesis (the formation ... Pegaptanib sodium injection (brand name Macugen) is an anti-angiogenic medicine for the treatment of neovascular (wet) age- ...

https://en.wikipedia.org/wiki/Pegaptanib

miR-221 is known as an anti angiogenic miRNA. Recent important studies have reported that miR-221 is also involved in induction ... RNA induced Silencing Complex (RISC) proteins SND1 and AEG-1 induces miR-221 expression in Liver cancer. In liver cancer miR- ... regulate p27Kip1 protein levels and cell cycle". Endocr Relat Cancer. 14 (3): 791-798. doi:10.1677/ERC-07-0129. PMID 17914108. ... "Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular ...

https://en.wikipedia.org/wiki/Mir-221_microRNA

This protein has a fairly neutral basal isoelectric point of 6.81. The proline and serine rich 2 protein contains a conserved ... Birrer, M.J., Bonome, T.A., Sood, A., and LU, C. (2013). Pro-angiogenic genes in ovarian tumor endothelial cell isolates. ... Nickel, W (Apr 2003). "The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export ... end of the specifically androgen-regulated gene protein (SARG) domain. The 5' end of the proline-serine rich 2 protein is ...

https://en.wikipedia.org/wiki/Proser2

Proto-Oncogene+Proteins+c-sis at the US National Library of Medicine Medical Subject Headings (MeSH) McKinnon RD, Matsui T, ... "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of ... Human genes encoding proteins that belong to the platelet-derived growth factor family include: PDGFA; PDGFB; PDGFC; PDGFD PGF ... and related proteins". Biochim. Biophys. Acta. 989 (1): 1-10. doi:10.1016/0304-419x(89)90031-0. PMID 2546599. Heldin CH (1992 ...

https://en.wikipedia.org/wiki/Platelet-derived_growth_factor

However, the resulting protein is still held together by disulfide bonds and remains inactive (although it can bind already ... July 2008). "Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation". Nature. 454 (7204): 656-660. ... Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI (March 1996). "Vascular endothelial growth factor-related protein: a ligand ... Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular ...

https://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor_C

The FasR part of the payload is intended to drive cell death in the endothelium of blood vessels where the chimeric protein is ... Ofranergene obadenovec, also known as VB-111, is an anti-angiogenic gene therapy. The vector is a non-replicating adenovirus 5 ... The payload is a chimeric gene encoding a fusion protein that combines the extracellular and intramembrane domains of the human ...

https://en.wikipedia.org/wiki/Ofranergene_obadenovec

June 2003). "An angiogenic role for the human peptide antibiotic LL-37/hCAP-18". The Journal of Clinical Investigation. 111 (11 ... Zanetti M, Gennaro R, Romeo D (October 1995). "Cathelicidins: a novel protein family with a common proregion and a variable C- ... Cowland JB, Johnsen AH, Borregaard N (July 1995). "hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific ... Lower plasma levels of human cathelicidin antimicrobial protein (hCAP18) appear to significantly increase the risk of death ...

https://en.wikipedia.org/wiki/Cathelicidin

... which encode easily identifiable protein markers. One example of such proteins is GFP (green fluorescent protein) which, when ... Enhanced antitumour activities have been demonstrated in a recombinant vaccinia virus encoding anti-angiogenic therapeutic ... The low pathogenicity of this virus is due in large part to its sensitivity to interferons, a class of proteins that are ... Attenuation of the virus by engineering a deletion of Met-51 of the matrix protein ablates virtually all infection of normal ...

https://en.wikipedia.org/wiki/Oncolytic_virus

Recent studies on Troponin I hypothesize that this protein performs its anti-proliferation effect on endothelial cells via ... Neighboring studies on other anti-angiogenic factors are evolving, however, the general mechanism of action is still unknown ...

https://en.wikipedia.org/wiki/Cartilage-derived_angiogenesis_inhibitor

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes ... 2004). "Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro". Oncogene. 23 (28 ... Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. GRCh38: ... Genes on human chromosome 12, All stub articles, Human chromosome 12 gene stubs, EF-hand-containing proteins). ...

https://en.wikipedia.org/wiki/DGKA

For instance, one can start with the gene for a protein that binds a certain sequence of DNA, and, by directing an unnatural ... "VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function". The Journal of Biological Chemistry. 280 (4): 2405-8. ... Both classes of aminoacyl-tRNA synthetases are multidomain proteins. In a typical scenario, an aaRS consists of a catalytic ... Aminoacyl tRNA therefore plays an important role in RNA translation, the expression of genes to create proteins. The synthetase ...

https://en.wikipedia.org/wiki/Aminoacyl_tRNA_synthetase

Cardiac alpha actin is a 42.0 kDa protein composed of 377 amino acids. Cardiac alpha actin is a filamentous protein extending ... "Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity". Proceedings of ... ". "Protein Information - Basic Information: Protein COPaKB ID: P68032". Cardiac Organellar Protein Atlas Knowledgebase. ... Shuster CB, Lin AY, Nayak R, Herman IM (1997). "Beta cap73: a novel beta actin-specific binding protein". Cell Motility and the ...

https://en.wikipedia.org/wiki/ACTC1

PHD finger protein 8 is a protein that in humans is encoded by the PHF8 gene. PHF8 belongs to the family of ferrous iron and ... "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". ... "OMIM: PHD finger protein 8; PHF8". Retrieved 2009-10-21. Abidi F, Miano M, Murray J, Schwartz C (Jul 2007). "A novel mutation ... PHF8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...

https://en.wikipedia.org/wiki/PHF8

For example, Notch is a signaling protein that regulates fate-choice, generally maintaining stem cells in a state of self- ... or angiogenic, niche due to the importance and pervasiveness of the blood vessels in the SGZ. The brain comprises many ... Wnt and bone morphogenic protein (BMP) signaling also are neurogenesis regulators, as well as classical neurotransmitters such ...

https://en.wikipedia.org/wiki/Subgranular_zone

Angiogenic Proteins * Prostaglandins * Progesterone Grant support * HD20869/HD/NICHD NIH HHS/United States ... Novel PGE-regulated genes are being identified in macaque granulosa cells, including adipose differentiation-related protein ( ... Finally, members of two classes of angiogenic factors, originally proposed as important for embryonic and pathologic ( ...

https://pubmed.ncbi.nlm.nih.gov/17127300/

... knockdown and anti-inhibin strategies robustly reduces permeability in vivo and alters the balance of pro and anti-angiogenic ... regulates angiogenic pathways that are targets for vessel normalization and ovarian cancer management. However, toxicities and ... We find that host cells also upregulated significantly more pro-angiogenic proteins, including CXCL1654, PIGF-255, and NOV56 in ... CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J. Biol. Chem. 278, 24200-24208 (2003). ...

https://www.nature.com/articles/s42003-022-03495-6?error=cookies_not_supported

Anti-Angiogenic Effects of BAI Proteins in Neuroblastoma Childrens Hospital of Philadelphia / Naomi Balamuth, MD Young ... Anti-Angiogenic (Metronomic) Chemotherapy in Children with Poor Prognosis. Dana-Farber Cancer Institute / Mark Kieran, MD, PhD ...

https://www.alexslemonade.org/grants/search?amp%3Bamp%3Bterms=&%3Bamp%3Bprogram=All&%3Bamp%3Bterm_node_tid_depth_1=All&%3Bamp%3Bstate=&%3Bamp%3Byear=&%3Bamp%3Bitems_per_page=10&%3Bamp%3Border=field_address_administrative_area&%3Bamp%3Bsort=asc&%3Byear=2009&terms=&program=All&term_node_tid_depth_1=All&state=&items_per_page=All&year=2006&order=taxonomy_vocabulary_55&sort=asc

MeSH Terms: Adoptive Transfer; Angiogenic Proteins/genetics; Angiogenic Proteins/metabolism*; Animals; Cells, Cultured; Colitis ... Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism*; Signal Transduction; Transcription, ... Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism*; Male; Mice, ... MAPK-activated protein kinase 2 (MK2), a major effector of the p38 MAPK stress and DNA damage response signaling pathway, and a ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=4212089

Angiogenic Proteins: A new descriptor class has been added for proteins that regulate the proliferation of new blood vessels. ... Amino Acids, Peptides and Proteins (D12): 246 new descriptors were added. Proteins and Enzymes: A total of 65 new enzyme ... Electron Transport Chain Complex Proteins and Photosynthetic Reaction Center Complex Proteins were added as new descriptors. ... Receptors, G-Protein-Coupled was added as new class to the Cell Surface Receptors. There are over 100 descriptors now re-treed ...

http://www.nlm.nih.gov/pubs/techbull/nd03/nd03_mesh.html

They have found, just recently, an anti-angiogenic protein. Very, very fine work and very well done, and something that we in ... He had to work out the fundamentals on a related protein because there was an insufficient amount of the HIV protein for him to ... He did work for a number of years on a representative protein so that he could work out its technology until that point in time ... Frank Robey and his team shed some light on how GP-120, the large protein on the surface of HIV, adheres to its target CD4 ...

https://history.nih.gov/x/zwH0

4. Angiogenic protein expression in advanced epithelial ovarian cancer.. Barton DP; Cai A; Wendt K; Young M; Gamero A; De ... 1. The Development of an Angiogenic Protein "Signature" in Ovarian Cancer Ascites as a Tool for Biologic and Prognostic ... The angiogenic activity of ascites in the course of ovarian cancer as a marker of disease progression.. Gawrychowski K; ... 7. Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=27258020&mod=related&page=1&from=&outid=&proj=

Proteomics reveals differential adsorption of angiogenic platelet lysate proteins on calcium phosphate bone substitute ... Endosomal sorting results in a selective separation of the protein corona from nanoparticles. Nature Communications 14, 295 ( ... A new methodology combining QCM-D and proteomic profiling enables characterization of protein adsorption on 2D surfaces. ... Multicomponent encapsulation into fully degradable protein nanocarriers via interfacial azide-alkyne click reaction in ...

https://www.mpip-mainz.mpg.de/publication-search/125755?person=%2Fpersons%2Fresource%2Fpersons48370

Application of angiogenic factors for therapy of erectile dysfunction: protein and DNA transfer of VEGF 165 into the rat penis ... Certain genes become activated at critical times to produce proteins vital to sustaining this pathway. Some researchers have ... which work via calcium channel and protein kinase mechanisms (see the image below). This results in the relaxation of smooth ...

https://emedicine.medscape.com/article/444220-overview

Agouti-Related Protein [D12.644.276.074] * Angiogenic Proteins [D12.644.276.100] * Angiopoietin-like Proteins [D12.644.276.100. ... Agouti-Related Protein [D12.776.467.074] * Angiogenic Proteins [D12.776.467.100] * Angiopoietin-like Proteins [D12.776.467.100. ... Angiogenic Peptide Angiogenic Peptides Angiogenic Protein Registry Number. 0. Previous Indexing. Angiogenesis Modulating Agents ... Amino Acids, Peptides, and Proteins [D12] * Proteins [D12.776] * Intercellular Signaling Peptides and Proteins [D12.776.467] * ...

https://meshb.nlm.nih.gov/record/ui?ui=D042501

... have identified that this bioactive substance is actually a protein. They have also named this protein as Bartonella angiogenic ... the BafA protein. They also observed that exposing human endothelial cells to the isolated BafA protein caused the cells to ... involving proteins called mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases (ERKs). The MAPK/ ... This is the very first report of a vascular endothelial growth factor (VEGF for short)-like protein produced by bacteria. ...

https://scitechdaily.com/lesions-of-doom-how-a-parasitic-bacterium-disrupts-blood-vessels-in-the-human-body/

... studying the role of the extracellular matrix protein Fibulin-7 and its anti-angiogenic properties. My long-term goal is to ...

https://www.nidcr.nih.gov/research/conducted-at-nidcr/intramural-research-labs/oral-immunity-infection-section/people

We demonstrate that levels of angiogenic proteins regulated by hypoxia-inducible factor (HIF)-1 and -2 (HIFs) remain elevated ...

https://www.jci.org/articles/view/163290/ga

... is necessary and sufficient to initiate preeclampsia by causing an angiogenic imbalance. This protein represents a potential ... sFLT-1, a protein uniquely present in the placenta, ...

https://www.nibib.nih.gov/virtual-workshop-technology-to-improve-maternal-health/summary-workshop-discussion

Also, lixisenatide upregulated protein expression of cerebral endothelial nitric oxide synthase and the angiogenic marker, ...

https://www.ncbi.nlm.nih.gov/pubmed/29864411

Sen P, Choudhury T, Smith EO, Langston C. Expression of angiogenic and vasculogenic proteins in the lung in alveolar capillary ... The FOXF1 protein is important in development of the lungs and their blood vessels. The FOXF1 protein is also involved in the ... Deletion of one copy of the FOXF1 gene in each cell reduces the production of the FOXF1 protein. A shortage of FOXF1 protein ... The protein produced from the FOXF1 gene is a transcription factor, which means that it attaches (binds) to specific regions of ...

https://medlineplus.gov/genetics/condition/alveolar-capillary-dysplasia-with-misalignment-of-pulmonary-veins/

Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate ... The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. Todorovic, Viktor; Chen, Chih-Chiun; Hay, Nissim; Lau, Lester ... Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Franzen, Carrie A; Chen ... Detection of differentially expressed basal cell proteins by mass spectrometry. Todorovic, Viktor; Desai, Bhushan V; Eigenheer ...

https://pesquisa.bvsalud.org/perinatal/?lang=es&q=au:Todorovic,+Viktor

A library of protein families and subfamilies indexed by function. Sociedad Mexicana de Proteómica (Mexican Society of ... Effect of pharmacological preconditioning with Morphine or Fentanyl on the expression of proteins related to the angiogenic ... A library of protein families and subfamilies indexed by function. Sociedad Mexicana de Proteómica (Mexican Society of ... of transplantation increased expression of cytokines has been observed in addition to increased expression of adhesion proteins ...

https://www.intechopen.com/profiles/200199

This is a protein which is an Anti-angiogenic protein, meaning it is like a sponge and it sops up growth factors that are ... So if there is enough of this anti-angiogenic protein, there wont be a sufficient supply of these growth factors getting to ... which results in considerable amounts of protein being spilled into the urine from the blood and also in protein and fluid ... Or if you supplied some of these growth factors that these proteins sop up, you might be able to do the same thing; to cure the ...

https://www.nichd.nih.gov/news/resources/links/Pages/transcriptpreeclampsia.aspx

The use of genetic therapies to deliver the genes for these proteins to the injured or defective sites represents an exciting ... o Cytokines, Growth Factors, and Biological Response Modifiers Cytokines and polypeptide growth factors, including angiogenic ... growth factors and bone morphogenetic proteins, have been shown to regulate many of the processes involved in wound healing ...

https://grants.nih.gov/grants/guide/pa-files/PA-94-031.html

Intercellular Signaling Peptides and Proteins [D12.644.276]. *Angiogenic Proteins [D12.644.276.100]. *Angiopoietins [D12.644. ... Circulating angiogenic factors associated with response and survival in patients with acute graft-versus-host disease: results ... Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease. ...

https://profiles.ucdenver.edu/display/205621

... have determined how certain short protein fragments, called peptides, can protect neuronal cells found in the light-sensing ... PEDF protein (center) has two domains with different functions. The 34-mer (blue, left) has anti-angiogenic properties. The 44- ... The PEDF protein has functionally distinct domains. The Becerra lab previously found that each domain can work independently. ... Further, the 44-mer and 17-mer peptides work by binding to a protein receptor (PEDF-R) on the surface of neurons. PEDF ...

https://www.nei.nih.gov/about/news-and-events/news/scientists-unravel-function-sight-saving-growth-factor

... suggesting that this particular family of angiogenic proteins plays an important role in placental angiogenesis [3]. ... We investigated the relationship of VEGF as an angiogenic growth factor and endostatin as an angiogenic inhibitor in patients ... The excess protein might be derived from the placenta, maternal platelets, or smooth muscle cells. Its elevation might ... Circulating angiogenic factors and the risk of pre-eclampsia. New England journal of medicine, 2004, 350(7):672-83. ...

https://www.emro.who.int/ar/emhj-volume-12-2006/volume-12-issue-1-2/serum-endostatin-and-vascular-endothelial-growth-factor-levels-in-patients-with-pre-eclampsia.html

https://www.emro.who.int/emhj-volume-12-2006/volume-12-issue-1-2/serum-endostatin-and-vascular-endothelial-growth-factor-levels-in-patients-with-pre-eclampsia.html

... including the development of microscopic tumor capillaries and expression of a key angiogenic protein, compared with mice that ... Almog has extensive hands-on experience with a variety of techniques ranging from the molecular level (DNA, RNA and proteins) ... Losordo is internationally recognized for his groundbreaking work in the use of gene, protein, and cell therapies to promote ... He teaches Food Analysis and Food Protein Biotechnology. His current research interests include (i) the molecular mechanisms by ...

https://angio.org/high-tech-delivery-of-common-spice-into-tumors-holds-promise-for-cancer-prevention

Angiogenic Peptide. Angiogenic Peptides. Angiogenic Protein. Peptide, Angiogenic. Protein, Angiogenic. Tree number(s):. D12.644 ... Angiogenic Proteins - Preferred Concept UI. M0441466. Scope note. Intercellular signaling peptides and proteins that regulate ... Angiogenic Proteins Entry term(s). Angiogenic Protein Protein, Angiogenic Angiogenic Peptides - Related but not broader or ... Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ...

https://decs.bvsalud.org/en/ths/resource/?id=38236&filter=ths_exact_term&q=PROTE%C3%8DNAS+ANGIOG%C3%8ANICAS

Researchers identified a protein involved in advanced diabetic retinopathy. The finding may explain why current treatments don ... References: Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative ... Protein Involved in Diabetic Eye Disease. At a Glance. *Researchers identified a protein involved in an advanced stage of ... The protein was also present at high levels in low-VEGF aqueous fluid from the eyes of patients who had recently received anti- ...

https://www.nih.gov/news-events/nih-research-matters/protein-involved-diabetic-eye-disease

https://meshb-prev.nlm.nih.gov/record/ui?ui=D042501

Amino Acids, Peptides and Proteins (D12): 246 new descriptors were added. (nih.gov)
Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions ( ANGIOGENESIS, PHYSIOLOGICAL ). (nih.gov)
Researchers at the National Eye Institute (NEI) have determined how certain short protein fragments, called peptides, can protect neuronal cells found in the light-sensing retina layer at the back of the eye. (nih.gov)
A team led by Patricia Becerra, Ph.D., chief of the NEI Section on Protein Structure and Function, had previously derived these peptides from a protein called pigment epithelium-derived factor (PEDF), which is produced by retinal pigment epithelial cells that line the back of the eye. (nih.gov)
Further, the 44-mer and 17-mer peptides work by binding to a protein receptor (PEDF-R) on the surface of neurons. (nih.gov)

TGFβ family members, particularly BMP9 and TGFβ, are the most examined regulators of angiogenesis but have not been effective as targets for angiogenic therapy due to their pleiotropic functions in cancer and normal physiology 4 , 5 . (nature.com)
16. Biological Pathways Involved in Tumor Angiogenesis and Bevacizumab Based Anti-Angiogenic Therapy with Special References to Ovarian Cancer. (nih.gov)
Through these experiments, the scientists determined that B. henselae can stimulate angiogenesis in human endothelial cells only if it possesses a functional copy of the gene that "codes for," or guides the synthesis of, the BafA protein. (scitechdaily.com)
We believe that BafA proteins can be leveraged as tools for studying angiogenesis, and we also consider potential medical benefits," reports Prof Doi. (scitechdaily.com)
Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS . (nih.gov)
Patients may also receive drugs that inhibit vascular endothelial growth factor (VEGF), a protein that stimulates angiogenesis. (nih.gov)
In fact, anti-VEGF therapy didn't affect the ability of aqueous fluid from patients to trigger angiogenesis, despite low levels of the protein. (nih.gov)
Most importantly, inhibiting both VEGF and angiopoietin-like 4 reduced angiogenesis more than targeting just one of the proteins. (nih.gov)
Mice that received the curcumin microparticles had significantly less tumor growth and a reduction in markers of tumor angiogenesis, including the development of microscopic tumor capillaries and expression of a key angiogenic protein, compared with mice that received a placebo. (angio.org)
Oxygen tension and cytokines have been shown to influence trophoblast VEGF expression, suggesting that this particular family of angiogenic proteins plays an important role in placental angiogenesis [3]. (who.int)

Finally, members of two classes of angiogenic factors, originally proposed as important for embryonic and pathologic (tumorigenic) vasculogenesis, appear induced in the granulosa layer of the preovulatory follicle, i.e., vascular endothelial growth factor (VEGF) and angiopoietin (ANGPT). (nih.gov)
This is the very first report of a vascular endothelial growth factor (VEGF for short)-like protein produced by bacteria. (scitechdaily.com)
We demonstrate that levels of angiogenic proteins regulated by hypoxia-inducible factor (HIF)-1 and -2 (HIFs) remain elevated in diabetic eyes despite treatment with anti-VEGF therapy. (jci.org)
By restricting oxygen flow to retinal cells, the team went on to discover a protein called angiopoietin-like 4 that, like VEGF, is present at much higher levels in the oxygen-deprived cells. (nih.gov)
The protein was also present at high levels in low-VEGF aqueous fluid from the eyes of patients who had recently received anti-VEGF therapy. (nih.gov)
Meanwhile, the protein might prove useful for predicting which diabetic retinopathy patients will respond to anti-VEGF therapy. (nih.gov)
Nous avons déterminé la concentration d'endostatine et de VEGF dans le sérum de 20 femmes non enceintes en bonne santé et de 64 femmes enceintes : 20 en bonne santé, 20 ayant une prééclampsie bénigne et 24 une prééclampsie grave. (who.int)
We investigated the relationship of VEGF as an angiogenic growth factor and endostatin as an angiogenic inhibitor in patients with pre-eclampsia. (who.int)
Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. (neuromics.com)
Avastin exerts its anti-angiogenic activity by binding to soluble vascular endothelial growth factor (VEGF), a signaling protein that promotes the growth of new blood vessels. (sartorius.com)
Expression of ChM-I decreased, while expression of VEGF and other pro-angiogenic factors increased, in OA cartilage. (jrheum.org)

Receptors, G-Protein-Coupled was added as new class to the Cell Surface Receptors. (nih.gov)
By binding to these receptors, BafA triggered the activation of a process inside the cells, involving proteins called mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases (ERKs). (scitechdaily.com)
Proteomic analysis of EV produced by EC in the proinflammatory conditions showed presence of several pro-inflammatory and immune proteins along with an enrichment in angiogenic receptors. (nih.gov)

During my postdoctoral work, I gained experience in molecular biology and biochemistry, specifically, studying the role of the extracellular matrix protein Fibulin-7 and its anti-angiogenic properties. (nih.gov)
Our major research interests are in exploring the role of extracellular matrix components (soluble secreted proteins and extracellular vesicles) in cancer and intercellular communication. (edu.au)

Targeting inhibin in vivo through knockdown and anti-inhibin strategies robustly reduces permeability in vivo and alters the balance of pro and anti-angiogenic mechanisms resulting in vascular normalization. (nature.com)
Dr. Richard Levine - Preeclampsia is a disease of pregnancy usually occurring in first pregnancies and it is characterized by high blood pressure and generalized vascular leakiness, which results in considerable amounts of protein being spilled into the urine from the blood and also in protein and fluid penetrating the tissues. (nih.gov)
OBJECTIVE: Chondromodulin-I (ChM-I), a cartilage derived anti-angiogenic factor, has been shown to regulate the vascular invasion during endochondral bone formation. (jrheum.org)
Immunohistochemical studies showed that vascular invasion occurred in proximity to chondrocytes with high expression of pro-angiogenic markers, and decreased expression of ChM-I. CONCLUSION: High expression of ChM-I was detected in articular cartilage of growing and normal adult joints, implicating its role in the maintenance of avascularity of intact articular cartilage. (jrheum.org)

Proteomics reveals differential adsorption of angiogenic platelet lysate proteins on calcium phosphate bone substitute materials. (mpg.de)

MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer. (nih.gov)
4. Angiogenic protein expression in advanced epithelial ovarian cancer. (nih.gov)
7. Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study. (nih.gov)
An increase in endothelial angiogenic ability, as well as overall increases in secreted VEGFA, ICAM1, and VCAM1 protein expression, was noted after epithelial exposure. (cdc.gov)
Low IGFBP3 expression is associated with a high expression of angiogenic proteins related to HIF- 2? (rusthuisavondvrede.be)
RT-PCR and immunoblot analyses confirmed that MALAT1 suppression reduced FGF2 expression, and Enzyme-Linked Immunosorbent Assays revealed that transfection with MALAT1 siRNAs reduced FGF2 protein secretion from neuroblastoma cells. (garvan.org.au)
Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis. (jrheum.org)
RESULTS: Abundant expression of ChM-I protein was detected in avascular regions of the developing and adult healthy articular cartilage. (jrheum.org)

Secretome can be defined as the total set of proteins released from normal and/or cancer cells into the surrounding microenvironment. (edu.au)

Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). (bvsalud.org)

Previous studies on Bartonella henselae (B. henselae for short), the bacterium responsible for the cat-scratch disease, have shown that it can directly "inject" proteins that inhibit programmed cell death (apoptosis) into the endothelial cells. (scitechdaily.com)

This is a protein which is an Anti-angiogenic protein, meaning it is like a sponge and it sops up growth factors that are required for maintenance of the health of blood vessels. (nih.gov)
So if there is enough of this anti-angiogenic protein, there won't be a sufficient supply of these growth factors getting to where they need to go and the woman will develop Preeclampsia. (nih.gov)
Circulating angiogenic factors associated with response and survival in patients with acute graft-versus-host disease: results from Blood and Marrow Transplant Clinical Trials Network 0302 and 0802. (ucdenver.edu)
Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease. (ucdenver.edu)

They also observed that exposing human endothelial cells to the isolated BafA protein caused the cells to multiply. (scitechdaily.com)
A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. (neuromics.com)

Hypoxia, a driver of tumor growth and metastasis, regulates angiogenic pathways that are targets for vessel normalization and ovarian cancer management. (nature.com)

Proteins and Enzymes: A total of 65 new enzyme classes have been added to the category of Enzymes. (nih.gov)
Several new major enzyme categories include: DNA Repair Enzymes, Metalloexopeptidases, Oxidoreductases Acting on CH-CH Group Donors, Proprotein Convertases, and Ubiquitin-Protein Ligase Complexes. (nih.gov)

Mutations in the FOXF1 gene that cause ACD/MPV result in an inactive protein that cannot regulate development, leading to abnormal formation of the pulmonary blood vessels and gastrointestinal tract. (medlineplus.gov)

1. The Development of an Angiogenic Protein "Signature" in Ovarian Cancer Ascites as a Tool for Biologic and Prognostic Profiling. (nih.gov)
15. The angiogenic activity of ascites in the course of ovarian cancer as a marker of disease progression. (nih.gov)

Anti-Angiogenic (Metronomic) Chemotherapy in Children with Poor Prognosis. (alexslemonade.org)

Endosomal sorting results in a selective separation of the protein corona from nanoparticles. (mpg.de)

PEDF protein (center) has two domains with different functions. (nih.gov)
The PEDF protein has functionally distinct domains. (nih.gov)
Without the presence of proteins and other cells in their usual retinal environment, immature photoreceptors quickly die but can be preserved with PEDF. (nih.gov)
Becerra and colleagues found that PEDF stimulates amacrine cells to develop neurites in their cell culture model and that the 44-mer and 17-mer were at least as effective - or better - at stimulating these connections than the native protein. (nih.gov)
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. (neuromics.com)

MAPK-activated protein kinase 2 (MK2), a major effector of the p38 MAPK stress and DNA damage response signaling pathway, and a critical regulator of pro-inflammatory cytokine production, has been identified as a key contributor to colon tumorigenesis under conditions of chronic inflammation. (nih.gov)

They have also named this protein as Bartonella angiogenic factor A, or "BafA" for short. (scitechdaily.com)
The protein produced from the FOXF1 gene is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of many other genes. (medlineplus.gov)
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. (nih.gov)

Dr. Richard Levine - Basically in this article we described the characteristics of a second protein that we have discovered, maybe related to Preeclampsia and in this article we more or less demonstrate that it is important in causing what we believe is the cause of this disease. (nih.gov)
So the implications are if you could reduce even the level of one of these proteins, you could probably roll back the disease or prevent the disease from happening. (nih.gov)
We also think that since these proteins are elevated two to three months before the onset of the disease, high levels can be used as a marker to indicate that a woman is susceptible to developing the disease and may get the disease later on in the pregnancy. (nih.gov)
Researchers identified a protein involved in an advanced stage of diabetic retinopathy, a diabetic eye disease that threatens vision. (nih.gov)

Deletion of one copy of the FOXF1 gene in each cell reduces the production of the FOXF1 protein. (medlineplus.gov)

The scientists also speculate that BafA proteins could be used in regenerative medicine, which is a highly specialized branch of medicine that deals with replacing or regenerating lost or damaged parts of the body. (scitechdaily.com)

Moreover, we generated the iCMFs with hiPSC-CMs with mutations in myosin-binding protein C (MYBPC3) to have a proof-of-concept of iCMFs in modeling cardiac hypertrophic phenotype. (stanford.edu)

If we want to exploit the protein for therapeutics, we need to separate out the regions responsible for its various properties and determine how each of them works. (nih.gov)
The 34-mer (blue, left) has anti-angiogenic properties. (nih.gov)

Novel PGE-regulated genes are being identified in macaque granulosa cells, including adipose differentiation-related protein (ADFP). (nih.gov)
In eukaryotic cells, proteins can be secreted by classical and non-classical secretory pathways. (edu.au)

The FOXF1 protein is important in development of the lungs and their blood vessels. (medlineplus.gov)

The way to distinguish Preeclampsia from these other conditions would undoubtedly be to take a blood sample and find the high levels of one or both of these proteins. (nih.gov)

The FOXF1 protein is also involved in the development of the gastrointestinal tract. (medlineplus.gov)
A shortage of FOXF1 protein affects the development of pulmonary blood vessels and causes the main features of ACD/MPV. (medlineplus.gov)

Importantly, addition of recombinant FGF2 protein to the cell culture media reversed the effects of MALAT1 siRNA on vasculature formation. (garvan.org.au)

It is estimated that about 10-15% of the proteins encoded by the human genome can be secreted by the well characterised classical secretory pathway. (edu.au)
In particular, the present invention relates to angiogenic extracts obtained from deer antler velvet, and compositions containing said extracts for use in the treatment of wounds, injuries and diseases in human and animal medical practice. (patentsencyclopedia.com)

These two broad categories bring together the protein components that are part of biological respiration and photosynthesis. (nih.gov)

Antibacterial Nanostructured Surfaces Modulate Protein Adsorption, Inflammatory Responses, and Fibrous Capsule Formation. (mpg.de)

Dr. Richard Levine - Well this is the second protein of this type that we have found, and we believe that most of the types of Preeclampsia are caused by these two proteins. (nih.gov)

Anatomy2

Diseases1

Chemicals and Drugs14

Phenomena and Processes1

Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. (1/368)

Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: differential effect on proliferating endothelial cells. (2/368)

Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer. (3/368)

Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. (4/368)

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. (5/368)

Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (6/368)

Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. (7/368)

Circulating proangiogenic cytokines and angiogenesis inhibitor endostatin in untreated patients with chronic lymphocytic leukemia. (8/368)

Angiogenic Proteins

Cysteine-Rich Protein 61

Angiogenesis Inducing Agents

Vascular Endothelial Growth Factor A

Neovascularization, Physiologic

Neovascularization, Pathologic

Vascular Endothelial Growth Factor Receptor-1

Vascular Endothelial Growth Factors

Endothelial Growth Factors

Endothelial Cells

Lymphokines

Fibroblast Growth Factor 2

Angiogenesis Inhibitors

Endothelium, Vascular

Vascular Endothelial Growth Factor Receptor-2

Angiopoietin-1

Angiopoietin-2

Pregnancy Proteins

Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. (1/368)

Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: differential effect on proliferating endothelial cells. (2/368)

Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer. (3/368)

Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. (4/368)

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. (5/368)

Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (6/368)

Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. (7/368)

Circulating proangiogenic cytokines and angiogenesis inhibitor endostatin in untreated patients with chronic lymphocytic leukemia. (8/368)

Vascular endothelial growth inhibitor

Benjamin P. Sachs

Syndecan 1

Syndecan-2

Angiopoietin-related protein 1

Syndecan-4

CXCL1

Syndecan-3

NOV (gene)

EGLN1

Stem-cell niche

Histidine-rich glycoprotein

TMEM155

Thrombospondin 1

Mitogen-activated protein kinase kinase kinase 6

Placental growth factor

Exosome (vesicle)

JMJD6

Diabetic retinopathy

Silmitasertib

Lee Byung-heon (biochemist)

Angiogenesis

Proteases in angiogenesis

HYAL1

Cystine knot

Junctional adhesion molecule

FGFBP1

Pre-eclampsia

PEDF

GBP1

Proto-oncogene tyrosine-protein kinase Src

Interferon

Postpartum psychosis

Philip Lazarovici

Mitogen

Tasquinimod

TSPAN7

Chromosome 6

Mir-126

Reverse transcription polymerase chain reaction

Glucose-6-phosphate isomerase

Kidney cancer

MicroRNA

Pegaptanib

Mir-221 microRNA

Proser2

Platelet-derived growth factor

Vascular endothelial growth factor C

Ofranergene obadenovec

Cathelicidin

Oncolytic virus

Cartilage-derived angiogenesis inhibitor

DGKA

Aminoacyl tRNA synthetase