A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.
Agents that modulate the PHYSIOLOGIC ANGIOGENESIS process. This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety of other chemicals and pharmaceutical agents.
Endothelial cells that line venous vessels of the UMBILICAL CORD.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A highly vascularized extra-embryonic membrane, formed by the fusion of the CHORION and the ALLANTOIS. It is mostly found in BIRDS and REPTILES. It serves as a model for studying tumor or cell biology, such as angiogenesis and TISSUE TRANSPLANTATION.
The minute vessels that connect the arterioles and venules.
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
An extra-embryonic membranous sac derived from the YOLK SAC of REPTILES; BIRDS; and MAMMALS. It lies between two other extra-embryonic membranes, the AMNION and the CHORION. The allantois serves to store urinary wastes and mediate exchange of gas and nutrients for the developing embryo.
Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.
New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.
An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.
The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.
A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A cell line derived from cultured tumor cells.
The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
The finer blood vessels of the vasculature that are generally less than 100 microns in internal diameter.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Restoration of integrity to traumatized tissue.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
Six-carbon alicyclic hydrocarbons.
Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity.
Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Transplantation between animals of different species.
Glycoproteins which have a very high polysaccharide content.
Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A condition of decreased oxygen content at the cellular level.
The blood vessels which supply and drain the RETINA.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The formation of LYMPHATIC VESSELS.
A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Proteins that specifically inhibit the growth of new blood vessels (ANGIOGENESIS, PHYSIOLOGIC).
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.
Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
Relatively complete absence of oxygen in one or more tissues.
A basic helix-loop-helix transcription factor that plays a role in APOPTOSIS. It is composed of two subunits: ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR and HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT.
A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.
Elements of limited time intervals, contributing to particular results or situations.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Adherence of cells to surfaces or to other cells.
Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
An enzyme that catalyzes the transfer of 2-deoxy-D-ribose from THYMIDINE to orthophosphate, thereby liberating thymidine.
Compounds that inhibit the enzyme activity or activation of MATRIX METALLOPROTEINASES.
Dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and axonal guidance. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS, and binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Processes required for CELL ENLARGEMENT and CELL PROLIFERATION.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Established cell cultures that have the potential to propagate indefinitely.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The main trunk of the systemic arteries.
The movement of cells or organisms toward or away from a substance in response to its concentration gradient.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Proteins prepared by recombinant DNA technology.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Tumors or cancer of the LUNG.
Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)
Tumors or cancer of the human BREAST.
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
A vascular endothelial growth factor expressed in a variety of tissues. It binds with high specificity to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 and NEUROPILIN-1.
A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Gauze material used to absorb body fluids during surgery. Referred to as GOSSYPIBOMA if accidentally retained in the body following surgery.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Receptors such as INTEGRIN ALPHAVBETA3 that bind VITRONECTIN with high affinity and play a role in cell migration. They also bind FIBRINOGEN; VON WILLEBRAND FACTOR; osteopontin; and THROMBOSPONDINS.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
An enzyme that catalyzes the endonucleolytic cleavage of pancreatic ribonucleic acids to 3'-phosphomono- and oligonucleotides ending in cytidylic or uridylic acids with 2',3'-cyclic phosphate intermediates. EC 3.1.27.5.
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
A family of proteins that mediate axonal guidance. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
A transmembrane domain containing ephrin that binds with high affinity to EPHB1 RECEPTOR; EPHB3 RECEPTOR; and EPHB4 RECEPTOR. Expression of ephrin-B2 occurs in a variety of adult tissues. During embryogenesis, high levels of ephrin-B2 is seen in the PROSENCEPHALON; RHOMBENCEPHALON; developing SOMITES; LIMB BUD; and bronchial arches.
Signal molecules that are involved in the control of cell growth and differentiation.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The flow of BLOOD through or around an organ or region of the body.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Peptides composed of between two and twelve amino acids.
A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.
Tumors or cancer of the PROSTATE.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
An alpha integrin with a molecular weight of 160-kDa that is found in a variety of cell types. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds. Integrin alphaV can combine with several different beta subunits to form heterodimers that generally bind to RGD sequence-containing extracellular matrix proteins.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.
A vascular endothelial cell growth factor receptor whose expression is restricted primarily to adult lymphatic endothelium. VEGFR-3 preferentially binds the vascular endothelial growth factor C and vascular endothelial growth factor D and may be involved in the control of lymphangiogenesis.
A malignant epithelial tumor with a glandular organization.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
Antibodies produced by a single clone of cells.
Precursor of plasmin (FIBRINOLYSIN). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.
Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Tumors or cancer of the COLON.
An eph family receptor found in a variety of adult and embryonic tissues. Unlike the majority of proteins in this class there is little or no expression of EphB4 receptor in the BRAIN. It has been found at high levels in developing mammary glands and in invasive mammary tumors.
A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.
The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.
A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. (1/26)

Angiopoietin-1 (Ang1) has potential therapeutic applications in inducing angiogenesis, enhancing endothelial cell survival, and preventing vascular leakage. However, production of Ang1 is hindered by aggregation and insolubility resulting from disulfide-linked higher-order structures. Here, by replacing the N-terminal portion of Ang1 with the short coiled-coil domain of cartilage oligomeric matrix protein (COMP), we have generated a soluble, stable, and potent Ang1 variant, COMP-Ang1. This variant is more potent than native Ang1 in phosphorylating the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor and Akt in primary cultured endothelial cells, enhancing angiogenesis in vitro and increasing adult angiogenesis in vivo. Thus, COMP-Ang1 is an effective alternative to native Ang1 for therapeutic angiogenesis in vivo.  (+info)

Current methods for assaying angiogenesis in vitro and in vivo. (2/26)

Angiogenesis, the development of new blood vessels from an existing vasculature, is essential in normal developmental processes and in numerous pathologies, including diabetic retinopathy, psoriasis and tumour growth and metastases. One of the problems faced by angiogenesis researchers has been the difficulty of finding suitable methods for assessing the effects of regulators of the angiogenic response. The ideal assay would be reliable, technically straightforward, easily quantifiable and, most importantly, physiologically relevant. Here, we review the advantages and limitations of the principal assays in use, including those for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures and in vivo assays such as sponge implantation, corneal, chamber, zebrafish, chick chorioallantoic membrane (CAM) and tumour angiogenesis models.  (+info)

Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle. (3/26)

Increased skeletal muscle capillary density would be a logical adaptive mechanism to chronic hypoxic exposure. However, animal studies have yielded conflicting results, and human studies are sparse. Neoformation of capillaries is dependent on endothelial growth factors such as vascular endothelial growth factor (VEGF), a known target gene for hypoxia inducible factor 1 (HIF-1). We hypothesised that prolonged exposure to high altitude increases muscle capillary density and that this can be explained by an enhanced HIF-1alpha expression inducing an increase in VEGF expression. We measured mRNA levels and capillary density in muscle biopsies from vastus lateralis obtained in sea level residents (SLR; N=8) before and after 2 and 8 weeks of exposure to 4100 m altitude and in Bolivian Aymara high-altitude natives exposed to approximately 4100 m altitude (HAN; N=7). The expression of HIF-1alpha or VEGF mRNA was not changed with prolonged hypoxic exposure in SLR, and both genes were similarly expressed in SLR and HAN. In SLR, whole body mass, mean muscle fibre area and capillary to muscle fibre ratio remained unchanged during acclimatization. The capillary to fibre ratio was lower in HAN than in SLR (2.4+/-0.1 vs 3.6+/-0.2; P<0.05). In conclusion, human muscle VEGF mRNA expression and capillary density are not significantly increased by 8 weeks of exposure to high altitude and are not increased in Aymara high-altitude natives compared with sea level residents.  (+info)

Bartonella adhesin a mediates a proangiogenic host cell response. (4/26)

Bartonella henselae causes vasculoproliferative disorders in humans. We identified a nonfimbrial adhesin of B. henselae designated as Bartonella adhesin A (BadA). BadA is a 340-kD outer membrane protein encoded by the 9.3-kb badA gene. It has a modular structure and contains domains homologous to the Yersinia enterocolitica nonfimbrial adhesin (Yersinia adhesin A). Expression of BadA was restored in a BadA-deficient transposon mutant by complementation in trans. BadA mediates the binding of B. henselae to extracellular matrix proteins and to endothelial cells, possibly via beta1 integrins, but prevents phagocytosis. Expression of BadA is crucial for activation of hypoxia-inducible factor 1 in host cells by B. henselae and secretion of proangiogenic cytokines (e.g., vascular endothelial growth factor). BadA is immunodominant in B. henselae-infected patients and rodents, indicating that it is expressed during Bartonella infections. Our results suggest that BadA, the largest characterized bacterial protein thus far, is a major pathogenicity factor of B. henselae with a potential role in the induction of vasculoproliferative disorders.  (+info)

Vascular endothelial growth factor and angiogenesis. (5/26)

Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various ischemic and inflammatory diseases. A rich variety of pro- and antiangiogenic molecules have already been discovered. Vascular endothelial growth factor (VEGF) is an interesting inducer of angiogenesis and lymphangiogenesis, because it is a highly specific mitogen for endothelial cells. Signal transduction involves binding to tyrosine kinase receptors and results in endothelial cell proliferation, migration, and new vessel formation. In this article, the role of VEGF in physiological and pathological processes is reviewed. We also discuss how modulation of VEGF expression creates new therapeutic possibilities and describe recent developments in this field.  (+info)

The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. (6/26)

The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular development during embryogenesis. The soluble monomeric derivative of the extracellular domain of EphB4 (sEphB4) was designed as an antagonist of EphB4/EphrinB2 signaling. sEphB4 blocks activation of EphB4 and EphrinB2; suppresses endothelial cell migration, adhesion, and tube formation in vitro; and inhibits the angiogenic effects of various growth factors (VEGF and bFGF) in vivo. sEphB4 also inhibits tumor growth in murine tumor xenograft models. sEphB4 is thus a therapeutic candidate for vascular proliferative diseases and cancer.  (+info)

New insights into the biology of preeclampsia. (7/26)

Despite recent research progress, the biology of preeclampsia is still poorly understood and neither effective prediction nor causal therapy have yet emerged. Nevertheless, recent studies have documented new and exciting pathophysiological mechanisms for the origin and development of preeclampsia. These studies provide a more differentiated view on alterations of particular peptide systems with strong impact on angiogenesis and cardiovascular regulation in this pregnancy disorder. With the identification of the antiangiogenic factor soluble fms-like tyrosine kinase 1 and the agonistic autoantibody to the angiotensin II type 1 receptor, two factors have been described with a clear linkage to the development of the disease. This review focuses on the most recent and relevant insights into the biology of preeclampsia and develops hypotheses regarding possible links between the reported aspects of preeclampsia.  (+info)

A cell-based model exhibiting branching and anastomosis during tumor-induced angiogenesis. (8/26)

This work describes the first cell-based model of tumor-induced angiogenesis. At the extracellular level, the model describes diffusion, uptake, and decay of tumor-secreted pro-angiogenic factor. At the cellular level, the model uses the cellular Potts model based on system-energy reduction to describe endothelial cell migration, growth, division, cellular adhesion, and the evolving structure of the stroma. Numerical simulations show: 1), different tumor-secreted pro-angiogenic factor gradient profiles dramatically affect capillary sprout morphology; 2), average sprout extension speeds depend on the proximity of the proliferating region to the sprout tip, and the coordination of cellular functions; and 3), inhomogeneities in the extravascular tissue lead to sprout branching and anastomosis, phenomena that emerge without any prescribed rules. This model provides a quantitative framework to test hypotheses on the biochemical and biomechanical mechanisms that control tumor-induced angiogenesis.  (+info)

The aim: To find out typical pathomorphological differences in placenta of women with early and late preeclampsia. Materials and methods: Investigation includes 40 placentas from deliveries in women with preeclampsia (main group) and 40 placentas from physiological delivery in somatically healthy women, who had no complications during pregnancy (control group). Placentas in the main group were devided into two sub-groups (20 in each) - with early and late preeclampsia. Specialties of the blood vessels in normal pregnancy were investigated, and their structural transformation with the developement of preeclampsia, according to the appearence of perinatal pathology. Morphometrical data of the blood stream was investigated with the help of eyepiece and program Image Tools 3,6. Results: Significant decrease of weight (p,0,05), square and volume of placenta was common to early preeclampsia, comparing to the same characteristics in late Preeclampsia (PE). Specific gravity of villi without vessels, ...
Stay up-to-date on the latest research studies, and news. Be sure to subscribe here to get notified when we post new articles!. ​. #AskAnExpert , We asked our Preeclampsia Registry participants to submit their own research questions. Check out the Ask an Expert series providing answers to these questions. If you want to submit your research questions, enroll today or login!. ​. #ResearchRoundup , Read up on the latest preeclampsia, eclampsia, HELLP syndrome, and other hypertensive disorders of pregnancy research publications from each month in our Research Roundup. ...
Supplementary Materialsijms-20-03004-s001. colorimetric assay for evaluating cell metabolic activity (MTT assay) and HY build up was dependant on movement cytometry. Pro-angiogenic factor expression was determined by Western blot and quantitative real-time polymerase chain reaction (RT-qPCR). We confirmed the cytotoxic effect of HY-PDT and HP and showed that their effect is influenced by structural characteristics of the experimental model. We have pioneered a method for analyzing the effect of HP and cellular targeted HY-PDT on pro-angiogenic factor expression in CRC micro-tumors. Despite the inhibitory effect of HY-PDT and HP on CRC, the increased expression of some pro-angiogenic factors was observed. We also showed that CRC experimental micro-tumors created on quail CAM could be utilized for analyses of gene and protein expression. 0.05, ** 0.01, TG 003 *** 0.001). The experimental groups cultivated using 2D cell models were compared with experimental groups cultivated in 3D cell models (? ...
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sEphB4-HSA is a fusion protein that consists of the extracellular domain of human ephrin type-B receptor 4 (EphB4) and human serum albumin (HSA), which acts as a decoy to inhibit EphB4 signaling, leading to inhibition of tumor cell growth (PMID: 23721559, PMID: 25148033).. ...
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... angiogenesis modulating agents MeSH D27.505.696.377.077.077 - angiogenesis inducing agents MeSH D27.505.696.377.077.099 - ... fibrin modulating agents MeSH D27.505.519.421.500 - antifibrinolytic agents MeSH D27.505.519.421.750 - fibrinolytic agents MeSH ... lipotropic agents MeSH D27.505.954.248 - antineoplastic agents MeSH D27.505.954.248.025 - angiogenesis inhibitors MeSH D27.505. ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ...
Targeted agents are designed to be selective in their effects by modulating the activity of proteins necessary and essential ... for oncogenesis and maintenance of cancer, particularly enzymes driving the uncontrolled growth, angiogenesis, invasiveness, ... Targeted lung cancer agents in current use[edit]. While a very large number of agents targeting various molecular pathways are ... some small case series suggest that some agents currently in use may be beneficial in c-SCLC. Many targeted agents appear more ...
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For example, the Hsp90 inhibitor geldanamycin has been used as an anti-tumor agent. The drug was originally thought to function ... Together with its co-chaperones, Hsp90 modulates tumour cell apoptosis "mediated through effects on AKT, tumor necrosis factor ... angiogenesis, and metastasis. Hsp90 plays apparently conflicting roles in the cell, as it is essential for both the creation ... Both are important for de novo angiogenesis that is required for tumour growth beyond the limit of diffusion distance of oxygen ...
TNC is an adhesion-modulating extracellular matrix glycoprotein. It is highly expressed in tumor stroma and stimulates tumor- ... Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development. Cancer Biology, Vol. 12, 2002: pp ... potent bone resorptive agents) and stimulating bone resorption. After the breast-cancer cells have left the primary tumor, they ... MMP-2 is unlike other MMP's as its activity is modulated by metalloproteases called tissue inhibitor of metalloproteases (TIMP ...
These mosquito eaters have been used in the past as mosquito control agents, with varying success. Play media Many, if not all ... It is now well recognized that feeding ticks, sandflies, and, more recently, mosquitoes, have an ability to modulate the immune ... Mosquito saliva acts to reduce vascular constriction, blood clotting, platelet aggregation, angiogenesis and immunity, and ... Zeidner NS, Higgs S, Happ CM, Beaty BJ, Miller BR (January 1999). "Mosquito feeding modulates Th1 and Th2 cytokines in ...
In 1977, the growth modulating peptide was shown to be a glycyl-L-histidyl-L-lysine. It is proposed that GHK-Cu modulates ... In the late 1980s, copper peptide GHK-Cu started attracting attention as a promising wound healing agent. At picomolar to ... angiogenesis, and wound closure in both wound chambers and full thickness wounds. In one study, full‐thickness wounds of 6 ... GHK may directly modulate gene expression, which may explain the diversity of its biological actions. A repository of ...
In addition, S1P modulates the proliferation of skin cells. This in particular applies to keratinocytes while fibroblasts are ... Administration of S1P has been shown to protect oocytes from chemotherapeutic agents in vitro, as well as in vivo from ... In the vascular system, S1P regulates angiogenesis, vascular stability, and permeability. In the immune system, it is now ... angiogenesis. Given its role in creating new blood vessels, scientists recognize S1P as vital to human health - and a player in ...
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ROS have been shown to induce transcription factors and modulate signaling molecules involved in angiogenesis (MMP, VEGF) and ... The role of ROS in promoting tumor proliferation is further supported by the observation that agents with potential to inhibit ... In fact, most of the chemotherapeutic and radiotherapeutic agents kill cancer cells by augmenting ROS stress. The ability of ... Due to the dual role of ROS, both prooxidant and antioxidant-based anticancer agents have been developed. However, modulation ...
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... angiogenesis, and tissue regeneration. Microvesicles may also remove misfolded proteins, cytotoxic agents and metabolic waste ... Microparticles derived from monocytes aggravate atherosclerosis by modulating inflammatory cells. Additionally, microvesicles ... Angiogenesis, which is essential for tumor survival and growth, occurs when endothelial cells proliferate to create a matrix of ... Microvesicles play an important role in tumor angiogenesis and in the degradation of matrix due to the presence of ...
Cao, Yihai (2007-09-01). "Angiogenesis modulates adipogenesis and obesity". The Journal of Clinical Investigation. 117 (9): ... "Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome". ... "Angiogenesis in Obesity & Diabetes , School of Medicine". medicine.dundee.ac.uk. Retrieved 2017-02-22. "Axel Hirsch Prize for ... Cao, Y.; Chen, C.; Weatherbee, J. A.; Tsang, M.; Folkman, J. (1995-12-01). "gro-beta, a -C-X-C- chemokine, is an angiogenesis ...
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DG-041, a highly selective EP3 antagonist, has been proposed to warrant further study as anti-thrombosis agent. GR 63799X, MB- ... Takeuchi K, Kato S, Amagase K (2010). "Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity". ... and a tumor-associated angiogenesis and lymphangiogenesis. Many drugs that act on EP3 and, often, other prostaglandin receptors ...
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Gα12 and Gα13 modulate cytoskeletal remodeling and cell-shape changes and Gαq modulates several cellular effector functions. ... It was also shown in vivo that S1P synergizes with angiogenic factors such as FGF-2 and VEGF in inducing angiogenesis and ... Fingolimod, a drug which internalizes the receptor, is approved as a disease modifying agent in MS. There are other Sphingosine ... Depending on the G protein coupled with the S1PR1, diverse cellular effects are achieved: Gαi and Gαo modulate cellular ...
In catalyzing the synthesis of thromboxanes, TXA synthase is involved in a flux pathway that can modulate the amount of ... Ratti S, Quarato P, Casagrande C, Fumagalli R, Corsini A (August 1998). "Picotamide, an antithromboxane agent, inhibits the ... angiogenesis, and metastasis. Thromboxane synthesis Eicosanoid synthesis Prostanoid 12-Hydroxyheptadecatrienoic acid GRCh38: ...
Lessons learned from the successes and failures of siderophore-conjugate drugs evaluated during the development of novel agents ... and modulating the responses of dendritic cells and cells of the adaptive immune response. Animal models indicate that host ... and angiogenesis modulation. These immunomodulatory effects have only recently begun to receive attention. Several methods have ... Antimicrobial peptides have been used as therapeutic agents; their use is generally limited to intravenous administration or ...
As described above in mechanisms of tumor evasion, the tumor cells are modulating the immune response in their profit. It is ... The researchers report that when killing cancer cells with this agent uptake and presentation by antigen presenting dendritic ... promotion of tumor growth and angiogenesis. Tumor cells have non-classical MHC class I on their surface, for example HLA-G. HLA ...
Wolf A, Herb M, Schramm M, Langmann T (June 2020). "The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis ... TSPO ligands (endogenous or synthetic) modulate the action of this receptor, activating the transport of cholesterol from the ... "The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia ... Tanimoto Y, Onishi Y, Sato Y, Kizaki H (February 1999). "Benzodiazepine receptor agonists modulate thymocyte apoptosis through ...
It does not act as a chemotactic agent but rather decrease T cell migration suggesting a mechanism of heterologous receptor ... A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia. Sci Signal 10.28900043 Kim SV, ... G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin. Sci Rep 7:692.781.pdf Bauer ...
Norrby K (1995). "Evidence of a dual role of endogenous histamine in angiogenesis". Int J Exp Pathol. 76 (2): 87-92. PMC ... Consequently, unlike the H1-antihistamines which are sedating, H3-antihistamines have stimulant and cognition-modulating ... a close relative of diphenhydramine used mainly as a skeletal muscle relaxant and anti-Parkinsons agent) Periciazine (low- ... Histamine also promotes angiogenesis. Antihistamines suppress the histamine-induced wheal response (swelling) and flare ...
The role of angiogenesis in the support of myleoma was first discovered by Vacca in 1994. They discovered increased bone marrow ... The molecule had been reported to be an even more potent teratogenic agent than thalidomide in rats, rabbits and monkeys. ... Thalidomide and its immune-modulating analogs alter the production of the inflammatory cytokines TNF-α, IL-1, IL-6, IL-12 and ... Angiogenesis or the growth of new blood vessels has been reported to correspond with MM progression where vascular endothelial ...
"Gelatinase B modulates selective opening of the blood-brain barrier during inflammation". Department of Neurology, University ... "Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on ... Neurogenesis saling terkait dengan angiogenesis juga terjadi bergelombang yang diawali dengan migrasi neuroblas dengan ekspresi ... senyawa spin trap agent seperti alpha-phenyl-N-t-butylnitrone (PBN) dan disodium- [tert-butylimino)methyl]benzene-1,3- ...
Neurotrophic factors have the ability to modulate neuronal growth during development to maintain existing cells and to allow ... and inhibitors of angiogenesis, such as pigment epithelium-derived factor (PEDF), rAAV-mediated expression of PEDF, angiostatin ... Intravitreal medication, such as anti-VEGF or corticosteroid agents. *Vitreoretinal surgery. *Use of nutritional supplements ...
2005). "Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic ... a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma". Journal of Medicinal Chemistry. 58 (15): 6093-113. doi: ... positive regulation of angiogenesis. • G-protein coupled receptor signaling pathway. Sources:Amigo / QuickGO. ... "CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast ...
It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural ... is an NOS inhibitor that is under development as a neuroprotective agent for the treatment of traumatic brain injury.[1] Other ... is involved in regulation of cardiac function and angiogenesis (growth of new blood vessels). NO produced by eNOS has been ...
HA fragments promote angiogenesis, and hyaluronidases produce these fragments.[18] Hypoxia also increases production of HA and ... A fasciacyte is a type of biological cell that produces hyaluronan-rich extracellular matrix, and modulates the gliding of ... and minimal stabilisation of the HA chains through chemical agents such as NASHA (non-animal stabilised hyaluronic acid)[68] ... Due to its ability to regulate angiogenesis by stimulating endothelial cells to proliferate, hyaluronan can be used to create ...
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis». Proc. ... Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation». J ... Transforming growth factor-beta inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine ...
positive regulation of angiogenesis. • response to estrogen. • cellular response to indole-3-methanol. • negative regulation of ... DNA cross-linking agents are an important source of chromosome/DNA damage. Double-strand breaks occur as intermediates after ... "p300 Modulates the BRCA1 inhibition of estrogen receptor activity". Cancer Res. 62 (1): 141-51. PMID 11782371.. ... "Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1". Oncogene. 20 (34): 4640-9. doi:10.1038/sj.onc ...
Ikemoto, S.; Wise, R. A. (2002). "Rewarding effects of the cholinergic agents carbachol and neostigmine in the posterior ... Examples of such disruption include changes in normal odor-guided behavior, and impairments in modulating state and ... that is the area that modulates behavior during certain physiological and mental states. Thus, the olfactory tubercle may also ...
"A new anti-oestrogenic agent in late breast cancer".. Cite journal requires ,journal=. (help). ... Folkman discovered in the 1970s that angiogenesis - the growth of new blood vessels - plays a significant role in the ... and the complex then binds to DNA to modulate gene expression. Some of these proteins include NCoR and SMRT.[68] Tamoxifen ... It is a nonsteroidal agent with potent antiestrogenic properties which compete with estrogen for binding sites in breast and ...
"Saliva of the Yellow Fever mosquito, Aedes aegypti, modulates murine lymphocyte function"។ Parasite Immunology 26 (6-7): 295- ... Mosquito saliva also contains enzymes that aid in sugar feeding[៦៤] and antimicrobial agents to control bacterial growth in the ... Mosquito saliva negatively affects vascular constriction, blood clotting, platelet aggregation, angiogenesis and immunity, and ... It is now well recognized that feeding ticks, sandflies, and, more recently, mosquitoes, have an ability to modulate the immune ...
Lau L, Hansford LM, Cheng LS, Hang M, Baruchel S, Kaplan DR, Irwin MS (Mar 2007). "Cyclooxygenase inhibitors modulate the p53/ ... "Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents". Journal of the ... "COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality ...
AngiogenesisEdit. Further information: Angiogenesis. Also called neovascularization, the process of angiogenesis occurs ... Barritault D, Caruelle JP (March 2006). "[Regenerating agents (RGTAs): a new therapeutic approach]" [Regenerating agents (RGTAs ... It has been shown that the growth of tissue and extent of scar formation can be controlled by modulating the stress at a wound ... Angiogenesis occurs in overlapping phases in response to inflammation: *Latent period: During the haemostatic and inflammatory ...
Schoots O, Van Tol HH (2003). "The human dopamine D4 receptor repeat sequences modulate expression". Pharmacogenomics J. 3 (6 ... Dopamine receptors control neural signaling that modulates many important behaviors, such as spatial working memory.[19] ... This natural increase in delta FosB or viral overexpression of delta FosB within the NAc modulates sexual performance, and NAc ...
... is sold under the brand name Fibrimex for use as a binding agent for meat. The thrombin in Fibrimex derives from ... Esmon CT (July 1995). "Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the ... Tsopanoglou NE, Maragoudakis ME (February 2004). "Role of thrombin in angiogenesis and tumor progression". Seminars in ... Maragoudakis ME, Tsopanoglou NE, Andriopoulou P (April 2002). "Mechanism of thrombin-induced angiogenesis". Biochemical Society ...
Anti-Cancer Agents in Medicinal Chemistry (em inglês). 15 (1). *↑ Wang, Yi; Cortez, David; Yazdi, Parvin; Neff, Norma; Elledge ... positive regulation of angiogenesis. • response to estrogen. • cellular response to indole-3-methanol. • negative regulation of ... p300 Modulates the BRCA1 inhibition of estrogen receptor activity». Cancer Res. 62 (1): 141-51. PMID 11782371. A referência ... Anti-Cancer Agents in Medicinal Chemistry (em inglês). 15 (1). *↑ «INCA - Instituto Nacional de Câncer - Estimativa 2018 - ...
"The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly". Cell. 127 (3): 539-52. doi:10.1016/j.cell. ... frog embryos figured prominently in a study that used evolutionary principles to identify a novel vascular disrupting agent ... "An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis" ... "Telomerase modulates Wnt signalling by association with target gene chromatin". Nature. 460 (7251): 66-72. doi:10.1038/ ...
Immunomodulatory agents in the treatment of scleroderma INN. Mechanism of action[40][41]. Route of administration[40]. ... Immunoglobulin, modulates the immune system.. IV. N/A. Varies Methotrexate. Antifolate; inhibits dihydrofolate reductase.. PO, ... Cipriani P, Marrelli A, Liakouli V, Di Benedetto P, Giacomelli R (August 2011). "Cellular players in angiogenesis during the ... The inciting event is yet to be elucidated, but may be a viral agent, oxidative stress, or autoimmune. Endothelial cell damage ...
It is also suggested however that the pain modulated by the mu-opioid receptor and that modulated by the δ-opioid receptor are ... which does not produce the problems with convulsions seen with the earlier agents,[26] and the mixed μ/δ agonist DPI-3290, ... distinct types, with the assertion that DOR modulates the nociception of chronic pain, while MOR modulates acute pain.[9] ... "G-protein-coupled receptor heterodimerization modulates receptor function". Nature. 399 (6737): 697-700. doi:10.1038/21441 ...
CB2 receptors are also found throughout the gastrointestinal system, where they modulate intestinal inflammatory response.[32][ ... the active agent in cannabis, and other phytocannabinoids (plant cannabinoids).[5][7] The principal endogenous ligand for the ... "Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors". The Journal of Clinical ... The prevalence of this trend suggests that modulating CB2 receptor activity by either selective CB2 receptor agonists or ...
A fasciacyte is a type of biological cell that produces hyaluronan-rich extracellular matrix, and modulates the gliding of ... Due to its ability to regulate angiogenesis by stimulating endothelial cells to proliferate, hyaluronan can be used to create ... and minimal stabilisation of the HA chains through chemical agents such as NASHA (non-animal stabilised hyaluronic acid)[55] ... Matou-Nasri S, Gaffney J, Kumar S, Slevin M (2009). "Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 ...
Woodbury, Anna; Yu, Shan Ping; Wei, Ling; García, Paul (2013). "Neuro-Modulating Effects of Honokiol: A Review". Frontiers in ... Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo". Journal of Biological Chemistry. 278 (37): 35501-7. doi:10.1074/jbc. ... "Identification of Magnolol and Honokiol as Anxiolytic Agents in Extracts of Saiboku-to, an Oriental Herbal Medicine". Journal ... "Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent". Antioxidants & Redox Signaling. 11 (5): 1139-48. doi:10.1089/ ...
There is evidence that human-specific opioid-modulated cognitive traits rely not on coding differences for the receptors or ... and opioid receptor site-directed alkylating agent having narcotic agonist activity". Science. 204 (4390): 316-8. doi:10.1126/ ...
These are experimental agents and do not yet have a defined clinical use, although a number of drugs are currently in human ... Norby, K (April 1, 1995). "Evidence of a dual role of endogenous histamine in angiogenesis". PubMed. Int. J. Exp. Pathol. pp. ... Consequently, unlike the H1-antihistamines which are sedating, H3-antihistamines have stimulant and cognition-modulating ... Histamine also promotes angiogenesis.[6]. Antihistamines suppress the histamine-induced wheal response (swelling) and flare ...
It is also available as a flavoring agent, contributing a somewhat sour and astringent component to umami taste.[12] As an ... HIF1 is known to induce transcription of more than 60 genes, including genes involved in vascularization and angiogenesis, ... modulating epigenetic landscape or demonstrating hormone-like signaling.[6] As such, succinate links cellular metabolism, ... metabolism and angiogenesis.[42] The other two oncometabolites, fumarate and 2-hydroxyglutarate have similar structures to ...
angiogenesis modulating agent An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous ... morin (CHEBI:75092) has role angiogenesis modulating agent (CHEBI:50926) morin (CHEBI:75092) has role anti-inflammatory agent ( ... anti-inflammatory agent Any compound that has anti-inflammatory effects.. antihypertensive agent Any drug used in the treatment ... morin (CHEBI:75092) has role antibacterial agent (CHEBI:33282) morin (CHEBI:75092) has role antihypertensive agent (CHEBI:35674 ...
Antineoplastic Agents, Immunological. Antineoplastic Agents. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth ... More than 2 weeks since prior and no concurrent thrombolytic agents. * Anticoagulation therapy with warfarin or low molecular ...
Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Growth Inhibitors. Antineoplastic Agents, ... Antineoplastic Agents. Topoisomerase II Inhibitors. Topoisomerase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of ...
Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Physiological Effects of Drugs. Growth Inhibitors. ... Antineoplastic Agents. Antimetabolites. Molecular Mechanisms of Pharmacological Action. Antimetabolites, Antineoplastic. ...
Antineoplastic Agents. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Physiological Effects of ... Ling et al, 2007) A Chinese phase III clinical trial in advanced non-small-cell lung cancer, endostar--a new angiogenesis ... Ling et al, 2007) A Chinese phase III clinical trial in advanced non-small-cell lung cancer, endostar--a new angiogenesis ... It is hypothesized that other anti-angiogenic agents such as endostar, may augment the effect of chemotherapy regimens in CRC. ...
Antineoplastic Agents. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Physiological Effects of ... Antineoplastic Agents, Alkylating. Alkylating Agents. Molecular Mechanisms of Pharmacological Action. ... The FDA approved DTIC in 1975 and high dose intravenous bolus rIL-2 in 1998 and these are the only agents approved for therapy ... Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005 Feb 10;23(5):1011- ...
Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Growth Inhibitors. Antineoplastic Agents. To Top ...
Here we show that EM011 (9-bromonoscapine), a microtubule-modulating agent, inhibits a spectrum of angiogenic events by ... Here we show that EM011 (9-bromonoscapine), a microtubule-modulating agent, inhibits a spectrum... ... the master regulator of tumor angiogenesis. Thus, microtubule-disrupting agents that perturb the HIF-1α axis and ... the master regulator of tumor angiogenesis. Thus, microtubule-disrupting agents that perturb the HIF-1α axis and ...
Angiogenesis Modulating Agents / metabolism * Angiogenesis Modulating Agents / pharmacology * Angiogenic Proteins / ... In vivo Matrigel plug assay for angiogenesis, the inclusion of 1 nM apelin in the Matrigel resulted in clear capillary-like ...
Angiogenesis Modulating Agents (29). Angiotensin II Type 1 Receptor Blockers (21) • Agents that antagonize ANGIOTENSIN II TYPE ... Anti-Angiogenesis Effect (0) see Angiogenesis Inhibitors. Anti-Anxiety Agents (86) • Agents that alleviate ANXIETY, tension, ... Angiogenesis Inducing Agents (2). Angiogenesis Inhibitors (29) • Agents and endogenous substances that antagonize or inhibit ... Anti-Mycobacterial Agents (0) see Anti-Bacterial Agents. Anti-Obesity Agents (24) • Agents that increase energy expenditure and ...
... and/or antirestenotic agents are delivered to the wall of a blood vessel and antithrombotic agents, antiplatelet agents, and/or ... different quantities of therapeutic agents, or different release profiles of the same or different therapeutic agents in ... In particular, the invention relates to the delivery of different therapeutic agents, ... or antiangiogenic agents and/or vasodilators to a blood vessel. In one embodiment, antiproliferative, antineoplastic, ...
Angiogenesis Inhibitors. Phase 2. 8. Angiogenesis Modulating Agents. Phase 2. 9. Antibodies. Phase 2. ...
Angiogenesis Inhibitors. Phase 2. 46. Dihematoporphyrin Ether. Phase 2. 47. Angiogenesis Modulating Agents. Phase 2. ... Biomarkers of Angiogenesis and Disease in Patients With Unresectable Malignant Mesothelioma Treated on Clinical Trial CALGB- ...
Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and ... Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related ... Angiogenesis modulates adipogenesis and obesity J Clin Invest. 2007 Sep;117(9):2362-8. doi: 10.1172/JCI32239. ... Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and ...
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to ... This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits ... In vitro, these agents have been shown to increase the rate of apoptosis, and inhibit cell proliferation and angiogenesis. ... Check for active clinical trials using this agent. (NCI Thesaurus) fluorescent cRGDY PEG-Cy5.5 C dots An imaging agent composed ...
A number of molecularly targeted agents were reported to modulate angiogenesis, growth factor receptors, cell cycle, and ... and biologic agents [28]. Xanthohumol was reported to modulate activity of estrogen synthase and decrease estrogen synthesis in ... Xanthohumol is a prenylated chalcone naturally found in hop plants, previously reported to be an effective anticancer agent in ... However, at present, the use of these agents results in medical complications and different grades of toxicities, such as ...
"Angiogenesis Modulating Agents.". http://experiment.worldcat.org/entity/work/data/1433997986#Topic/angiogenesis_modulating_ ... Angiogenesis Modulating Agents.. This is a placeholder reference for a Topic entity, related to a WorldCat Entity. Over time, ... Angiogenesis Inducing Agents.. This is a placeholder reference for a Topic entity, related to a WorldCat Entity. Over time, ... http://experiment.worldcat.org/entity/work/data/1433997986#Topic/angiogenesis_modulating_agents ...
... has been directed toward the development of pharmacological agents that modulate specific pathways associated with angiogenesis ... Flt-1 and KDR ribozymes significantly decreased angiogenesis when tested in a corneal pocket model of VEGF-induced angiogenesis ... Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1: 27-31, 1995. ... Thomas K. A. Vascular endothelial growth factor, a potent and selective angiogenic agent. J. Biol. Chem., 271: 603-606, 1996. ...
Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effecter function of CD8þ T cells. Cancer Lett ... Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling. Carcinogenesis. 2010; ... Bhatt N. (2018) Cinnamon as a Cancer Therapeutic Agent. In: Waly M., Rahman M. (eds) Bioactive Components, Diet and Medical ... Rasayana drugs from the Ayurvedic system of medicine as possible radioprotective agents in cancer treatment. Integr Cancer Ther ...
The transcriptional regulation of ANGPTL4 can be modulated by several transcription factors, including PPAR,i,α,/i,, PPAR,i,β,/ ... including angiogenesis and vascular permeability, cell differentiation, tumorigenesis, glucose homoeostasis, lipid metabolism, ... protein belongs to a superfamily of secreted proteins structurally related to factors modulating angiogenesis known as ... modulating agents and structure-function relationships," Expert Review of Proteomics, vol. 9, no. 2, pp. 181-199, 2012. View at ...
... therapeutic efforts focused on modulating angiogenesis are increasing (32, 33, 34) . The initial agent investigated in this ... Is VEGF the best target if we wish to modulate angiogenesis in patients with MM? Although both preclinical and clinical data ... Patients receiving drugs and agents that inhibit or induce this enzyme, including some antifungal agents (45) and macrolide ... angiogenesis-modulating properties (34 , 61) . Thalidomide is a potent suppressor of VEGF in a number of in vitro models (62) ...
... angiogenesis modulating agents MeSH D27.505.696.377.077.077 - angiogenesis inducing agents MeSH D27.505.696.377.077.099 - ... fibrin modulating agents MeSH D27.505.519.421.500 - antifibrinolytic agents MeSH D27.505.519.421.750 - fibrinolytic agents MeSH ... lipotropic agents MeSH D27.505.954.248 - antineoplastic agents MeSH D27.505.954.248.025 - angiogenesis inhibitors MeSH D27.505. ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ...
A number of molecularly targeted agents had been reported to modulate angiogenesis development element receptors cell routine ... Nevertheless at present the usage of these real estate agents leads to medical complications and various marks of toxicities ... Amongst they are the chemotherapeutic real estate agents currently utilized as advanced and metastatic cervical tumor treatment ... Furthermore xanthohumol modulated the alkaline phosphatase isoenzymes which were indicated in malignant cells [8] and could ...
... endothelial cells are seeded on a thick gel of Basement Membrane Extract in the presence of angiogenesis modulating agents. If ... Cultrex® In Vitro Angiogenesis Assay Tube Formation Kit. $264.00. The Cultrex® In Vitro Angiogenesis Assay Tube Formation Kit ... Cultrex® In Vitro Angiogenesis Assay Kit provides a cost-effective method for investigation of prospective angiogenesis ... Cultrex® In Vitro Angiogenesis Assay Endothelial Cell Invasion Kit. View Details. $374.00 Add to cart ...
KEY WORDS: Endothelium; Exercise; Physiologic Neovascularization; Angiogenesis Modulating Agents.. How to cite this article. ... In this review, the main mechanisms involved in the physiological regulation of vasculogenesis and angiogenesis are addressed. ... angiogenesis). The angiogenic factor that induces morphological and functional changes in the endothelial cells is the VEGFA, ...
Angiogenesis Modulating Agents, Growth and Development, Lymphangiogenesis, Angiogenesis, Mouse Neonatal Retina, ... Angiogenesis plays a key role not only in normal development of organs and tissues, but also in many diseases in which blood ... Angiogenesis is the complex process of new blood vessel formation defined by the sprouting of new blood vessels from a pre- ... In adult life, blood vessels are generally quiescent so angiogenesis is an important target for novel drug development to try ...
Angiogenesis Modulating Agents, Wounds and Injuries, Wound healing, mouse, angiogenesis, diabetes mellitus, splint, surgical ... It has been utilized to investigate tumor angiogenesis, drug delivery and stem cell survival and engraftment1,2,6,7. With its ... There is, therefore, an increasing impetus to develop novel agents that promote wound repair. The testing of these has been ... Herein, we demonstrate the efficacy of these procedures by increasing oxidative stress in tissues by oxidant agents and ...
Angiogenesis is a physiological process implicated in growth, invasion and metastization of tumors. Here we have analyzed the ... Angiogenesis is a physiological process implicated in growth, invasion and metastization of tumors. Here we have analyzed the ... as an immune modulating agent. FEMS Immunol. Med. Microbiol. 50, 157-164. doi: 10.1111/j.1574-695X.2007.00258.x ... Human Angiogenesis-Related Proteins. The Human Angiogenesis Array Kit (Proteome ProfilerTM- ARY007 Array, R&D Systems, Inc., ...
Compared with other broad-spectrum agents that modulate angiogenesis through control of inflammation such as corticosteroid, ... Most of these agents modulate angiogenic pathways by blocking growth factors or specific signal mediators. Vascular endothelial ... Angiogenesis in wound healing. J Investig Dermatol Symp Proc . 2000; 5: 40-46. [CrossRef] [PubMed] ... Tumor angiogenesis. N Engl J Med . 2008; 358: 2039-2049. [CrossRef] [PubMed] ...
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. Clin Cancer ... Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis. Sharon ... Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis ... Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis ...
  • Angiogenesis Inhibitors. (worldcat.org)
  • The Cultrex® In Vitro Angiogenesis Assay Tube Formation Kit allows for the detection of inducers and inhibitors of endothelial cell tube formation. (trevigen.com)
  • The Cultrex® In Vitro Angiogenesis Assay Tube Formation Kit was developed for the evaluation of inducers and inhibitors of endothelial cell tube formation. (trevigen.com)
  • Cultrex ® In Vitro Angiogenesis Assay Kit provides a cost-effective method for investigation of prospective angiogenesis inhibitors in a 96 well plate format. (trevigen.com)
  • This study investigated the effects of Hsp90 inhibitors on client protein expression and key cellular functions required for tumor angiogenesis. (aacrjournals.org)
  • Thus, we identify Hsp90 inhibitors as important regulators of many aspects of tumor angiogenesis (and potentially lymphangiogenesis) and suggest that they may provide therapeutic benefit not only via direct effects on tumor cells but also indirectly by inhibiting the production of angiogenic cytokines and responses of activated endothelial cells that contribute to tumor progression and metastasis. (aacrjournals.org)
  • Chromatin remodeling agents such as histone deacetylase inhibitors have been shown to modulate gene expression in tumor cells and inhibit tumor growth and angiogenesis. (aacrjournals.org)
  • These results suggest that the combination of histone deacetylase inhibitors and VEGF receptor inhibitors may target multiple pathways in tumor progression and angiogenesis and represents a novel therapeutic approach in cancer treatment. (aacrjournals.org)
  • Attempts to target these critical processes involved in tumor angiogenesis have led to the clinical development of angiogenesis inhibitors. (aacrjournals.org)
  • The development of tumor-specific anti-angiogenic therapy was also catalyzed by the finding that inhibitors of angiogenesis appeared immune to the development of drug resistance by the tumor cells, a major restrain in current chemotherapy. (northwestern.edu)
  • Agents such as retinoids, cycloxygenase-2 (Cox-2) inhibitors, and epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitors are being tested for the prevention and treatment of hormonally unresponsive estrogen receptor-α-negative breast cancers. (aacrjournals.org)
  • Hwyda Arafat at the Kimmel Cancer Center at Thomas Jefferson University recently showed that angiotensin I-converting enzyme (ACE) was active in tumors from patients with pancreatic cancer, and that ACE inhibitors and angiotensin II receptor blockers (ARBs) blocked the production of a potent angiogenesis factor called VEGF in pancreatic cancer cell lines. (thefreedictionary.com)
  • As prostate tumors are also angiogenesis-dependent to grow and spread, angiogenesis inhibitors may help to reduce morbidity and mortality caused by such tumors. (farmabrasilis.org.br)
  • The association of angiogenesis inhibitors (e.g. (farmabrasilis.org.br)
  • While a very large number of agents targeting various molecular pathways are being developed and tested, the main classes and agents that are now being used in lung cancer treatment include: Inhibitors of Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI's): erlotinib (Tarceva)[unreliable medical source? (wikipedia.org)
  • Thus, microtubule-disrupting agents that perturb the HIF-1α axis and neovascularization cascade are attractive anticancer drug candidates. (oup.com)
  • Tumor proliferation requires neovascularization, the process of new blood vessel formation, otherwise known as angiogenesis. (cancernetwork.com)
  • A novel EC-specific tubulogenesis assay highlights strikingly different angiogenic properties of different EPCs: late OECs directly participate in tubulogenesis, whereas early EPCs augment angiogenesis in a paracrine fashion, with implications for optimizing cell therapies for neovascularization. (nih.gov)
  • Thus, we hypothesize that curcumin could promote neovascularization at sites of hindlimb ischemia in diabetes and might take effect via modulating the function of EPCs. (biomedcentral.com)
  • Neovascularization, including angiogenesis and vasculogenesis, plays a crucial role in the delivery of oxygen, nutrients, and other mediators at the injury and ischemic sites. (biomedcentral.com)
  • Although other angiogenic factors have been identified, VEGF is the most potent and specific regulator of angiogenesis and SU11248 targets not just one, but all 3 VEGF signaling pathways. (clinicaltrials.gov)
  • A number of molecularly targeted agents were reported to modulate angiogenesis, growth factor receptors, cell cycle, and inflammation in cervical cancer signaling pathways. (hindawi.com)
  • Considerable effort has been directed toward the development of pharmacological agents that modulate specific pathways associated with angiogenesis. (aacrjournals.org)
  • A number of molecularly targeted agents had been reported to modulate angiogenesis development element receptors cell routine and swelling in cervical tumor signaling pathways. (exposed-skin-care.net)
  • Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases. (bioportfolio.com)
  • Thus, suppression of specific integrin pathways or vascular endothelial growth factor signaling have been shown effective in the suppression of tumor-mediated angiogenesis and have led to subsequent initiation of clinical trials. (northwestern.edu)
  • Upon subcutaneous administration, factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex, which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways, thereby inhibiting tumor cell proliferation, angiogenesis, and metastasis of TF-overexpressing tumor cells. (newyorkoncology.com)
  • BACKGROUND AND PURPOSE: Angiogenesis involves multiple signaling pathways that must be considered when developing agents to modulate pathological angiogenesis. (bvsalud.org)
  • Targeted therapy of lung cancer refers to using agents specifically designed to selectively target molecular pathways responsible for, or that substantially drive, the malignant phenotype of lung cancer cells , and as a consequence of this (relative) selectivity, cause fewer toxic effects on normal cells. (wikipedia.org)
  • Studies have show that ursolic acid suppresses tumor formation, inhibits tumor growth, induces apoptosis, inhibits angiogenesis, inhibits signaling and activation pathways, induces tumor cell differentiation, and suppresses growth factor expression. (essense-of-life.com)
  • Recent research has suggested that plant polyphenols (which includes ursolic acid) might be used to sensitize tumor cells to chemotherapeutic agents and radiation therapy by inhibiting pathways that lead to treatment resistance. (essense-of-life.com)
  • In particular, we have investigated ribozymes that target the mRNA of the vascular endothelial growth factor (VEGF) receptors because VEGF signaling is an important mediator of tumor angiogenesis and metastasis. (aacrjournals.org)
  • Increased bone marrow angiogenesis and vascular endothelial growth factor (VEGF) levels are of adverse prognostic significance in patients with multiple myeloma (MM). VEGF, a soluble circulating angiogenic molecule, acts via receptor tyrosine kinases, including VEGF receptor 2. (aacrjournals.org)
  • One such pathway involves the vascular endothelial growth factor (VEGF) signal transduction, which is critical in angiogenesis and also important in tumor proliferation. (cancernetwork.com)
  • The vascular endothelial growth factor (VEGF) and the platelet-derived growth factor C (PDGF-C) are agents of great interest on tumour angiogenesis and may be modulated by the HIF-1. (usp.br)
  • The results were correlated with angiogenesis assessed by micro-vessel density (MVD) for CD34, CD105, VEGF and PDGF-C, with endothelial cell proliferation by nuclear staining for KI-67, and also with survival. (usp.br)
  • In this study, we investigated the biological effect of the histone deacetylase inhibitor NVP-LAQ824 in combination with the VEGF receptor tyrosine kinase inhibitor PTK787/ZK222584 on tumor growth and angiogenesis. (aacrjournals.org)
  • In addition, NVP-LAQ824 treatment inhibited the expression of angiogenesis-related genes such as angiopoietin-2 , Tie-2 , and survivin in endothelial cells and down-regulated hypoxia-inducible factor 1-α and VEGF expression in tumor cells. (aacrjournals.org)
  • Combination treatment with NVP-LAQ824 and PTK787/ZK222584 was more effective than single agents in inhibiting in vitro and in vivo VEGF-induced angiogenesis. (aacrjournals.org)
  • Evidence suggests that vascular endothelial growth factor (VEGF), a 40 kDa dimeric glycoprotein, promotes angiogenesis in each of these conditions, making it a highly significant therapeutic target. (elsevier.com)
  • The potential disadvantages of inhibiting VEGF will be discussed, as will the rationales for targeting other VEGF-related modulators of angiogenesis. (elsevier.com)
  • Moreover, treatment of human umbilical endothelial cells (HUVECs) with AnxA1 2-26 improved proliferation, shortened cycle, increased migration and actin polymerization similarly to those evoked by VEGF-A. The peptide treatment instead only potentiated the tube formation induced by VEGF-A. Collectively, our data showed that AnxA1 2-26 treatment favors the tissue regeneration after skin grafting by avoiding exacerbated inflammation and improving the angiogenesis process. (frontiersin.org)
  • Bevacizumab is a recombinant VEGF antibody derived from a humanized murine monoclonal antibody that can recognize all known isoforms of VEGF-A and prevents receptor binding, thereby inhibiting angiogenesis and tumour growth. (biomedcentral.com)
  • It is therefore likely, as has been demonstrated for other targeted agents such as herceptin, that benefit will be restricted to those patients whose tumours rely largely on VEGF signalling for their angiogenic response. (biomedcentral.com)
  • To investigate the possible influence of melatonin on angiogenesis, we studied the effect of melatonin on endogenous VEGF expression in three human cancer cell lines (PANC-1, HeLa and A549 cells). (ovid.com)
  • In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. (medkoo.com)
  • N-Acetylcysteine Suppresses LPS-Induced Pathological Angiogenesis. (bioportfolio.com)
  • Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS. (bioportfolio.com)
  • Angiogenesis occurs predominantly during development and is rare in adults ( 27 ) except for pathological states, where angiogenesis is a major contributor to several diseases, including rheumatoid arthritis ( 22 , 33 , 66 ), psoriasis ( 4 ), tumor growth and metastasis ( 28 ), diabetic retinopathy ( 23 ), cardiovascular disease ( 35 ), and bone repair ( 23 ). (asm.org)
  • These diseases are all characterized by the reduction of physiological angiogenesis and the following induction of pathological angiogenesis. (cdc.gov)
  • In addition, xanthohumol modulated the alkaline phosphatase isoenzymes that were expressed in malignant tissues [ 8 ] and was able to inhibit production of inflammatory factors, DNA synthesis and angiogenesis in MCF-7 cells, and breast cancer xenografts in mice [ 9 ]. (hindawi.com)
  • Furthermore xanthohumol modulated the alkaline phosphatase isoenzymes which were indicated in malignant cells [8] and could inhibit creation of inflammatory elements DNA synthesis and angiogenesis in MCF-7 cells and breasts tumor xenografts in mice [9]. (exposed-skin-care.net)
  • Helmestam M, Andersson H, Stavreusevers A, Brittebo E, Olovsson M. Tamoxifen modulates cell migration and expression of angiogenesis-related genes in human endometrial endothelial cells. (springer.com)
  • In the early 1970s (1) , Folkman hypothesized that solid tumor growth and metastasis are critically dependent on angiogenesis, the formation of new blood vessels from preexisting vasculature. (aacrjournals.org)
  • Angiogenesis has been acknowledged as an important requirement for growth and metastasis of tumors. (northwestern.edu)
  • Penfluridol: An antipsychotic agent suppresses lung cancer cell growth and metastasis by inducing G0/G1 arrest and apoptosis. (harvard.edu)
  • Discusses the role of chemokines in mediating leukocyte trafficking, angiogenesis, tumor cell metastasis, host defense, trauma-induced lung injury, and the progression of AIDS in the lung. (infibeam.com)
  • Targeted agents are designed to be selective in their effects by modulating the activity of proteins necessary and essential for oncogenesis and maintenance of cancer, particularly enzymes driving the uncontrolled growth, angiogenesis, invasiveness, and metastasis characteristic of malignant tumors. (wikipedia.org)
  • The role of myeloid cells in the promotion of tumour angiogenesis. (nih.gov)
  • In this Review the evidence for each of these cell types driving tumour angiogenesis is outlined, along with the mechanisms regulating their recruitment and activation by the tumour microenvironment. (nih.gov)
  • The attractiveness of the antiangiogenic approach has always been the wide therapeutic window, since all tumours (including liquid such as leukaemias) are angiogenesis dependent, that angiogenesis is highly restricted in the adult, that endothelium of the vessels are accessible and that any treatment would be amplified through subsequent tumour infarction. (biomedcentral.com)
  • Indeed, the central tenet that tumours are angiogenesis dependent (in that for a tumour to grow, this must be preceded by a wave of angiogenesis to deliver nutrients and meet the metabolic requirements of the growing tumour) has been challenged. (biomedcentral.com)
  • specifically, individual patients given antiangiogenic agents have yet to be selected based on the characteristics of their tumour. (biomedcentral.com)
  • The administration of agents based on the biology of the individual tumour (so-called personalized medicine) will become increasingly important not only to generate maximum therapeutic benefit to the patient but also to realize the optimal economic advantage from the finite resources available. (biomedcentral.com)
  • It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, a vascular endothelial growth factor receptor antagonist and an angiogenesis modulating agent. (nih.gov)
  • Recently, the dynamicity and integrity of microtubules have been implicated in the trafficking and efficient translation of the mRNA for HIF-1α (hypoxia-inducible factor), the master regulator of tumor angiogenesis. (oup.com)
  • GBM proliferates under a hypoxia environment and the hypoxia-inducible factor (HIF-1) plays a key role on the transcription of essential genes which promote angiogenesis and prevent cellular death. (usp.br)
  • Factors such as hypoxia, irradiation or chemotherapeutic agents can cause irreversible DNA damage and activate the apoptotic process, thus diminishing the risk of a possibly harmful mutation and malignant transformation (Kumar et al. (springeropen.com)
  • Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. (refine.bio)
  • Although it is known that exercise induces angiogenesis, a clear mechanism has remained elusive due to various experimental limitations. (bioportfolio.com)
  • Herein, we describe a targeted nanoparticle approach encapsulating either a PPARgamma activator or a prostaglandin E2 analog, each of which induces adipose tissue transformation and angiogenesis, facilitating the transformation of WAT into BAT. (pnas.org)
  • Here we show that EM011 (9-bromonoscapine), a microtubule-modulating agent, inhibits a spectrum of angiogenic events by interfering with endothelial cell invasion, migration and proliferation. (oup.com)
  • Here we show that angiogenesis is severely impaired in PSMA-null animals and that this angiogenic defect occurs at the level of endothelial cell invasion through the extracellular matrix barrier. (asm.org)
  • We show that PSMA inhibition, knockdown, or deficiency decreases endothelial cell invasion in vitro via integrin and PAK, thus abrogating angiogenesis. (asm.org)
  • An endothelial cell (EC)-specific angiogenesis assay was developed to functionally characterize angiogenic properties of 2 distinct putative endothelial progenitor cells (EPCs): early EPCs and late outgrowth endothelial cells (OECs). (nih.gov)
  • This book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis. (worldcat.org)
  • The impact of nanotechnology in advancing the applications of pro-and anti-angiogenesis strategies is also highlighted, along with stem cell and biotechnologies in research and development of angiogenesis modulating targets. (worldcat.org)
  • Our model reproduces corneal angiogenesis experiments and several anti-angiogenesis therapy results. (aimsciences.org)
  • Blocking one of these steps using an anti-angiogenesis agent may have limited results due to the tumor's ability to continue the angiogenesis process through use of angiogenesis factor redundancy. (thefreedictionary.com)
  • Ling et al, 2007) A Chinese phase III clinical trial in advanced non-small-cell lung cancer , endostar--a new angiogenesis inhibitor prolonged the overall survival, time to progression and improved response rate. (clinicaltrials.gov)
  • Sulforaphane [1- isothiocyanato-(4R)- methylsulfinyl)-butane], found in broccoli and other cruciferous vegetables, is a naturally occurring cancer chemopreventive agent, and is provided as a control inhibitor to visualize this process. (trevigen.com)
  • FOLFOX4 plus Avastin has been suggested as firstline regimen for advanced colorectal cancer by NCCN, a new angiogenesis inhibitor, known as Endostar(Recombinant Human Endostatin), prolonge. (bioportfolio.com)
  • Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. (drugbank.ca)
  • Withaferin A is cell permeable and potent angiogenesis inhibitor from the family of withanolides. (agscientific.com)
  • To identify biomarkers of effectiveness and to elucidate molecular mechanisms of action, we performed a comparative transcriptome profiling from p53-null mammary epithelium obtained from mice treated with three chemopreventive agents: a retinoid X receptor agonist (bexarotene, LGD1069), an EGFR-TK inhibitor (gefitinib, ZD1839), and a Cox-2 inhibitor (celecoxib, SC58635). (aacrjournals.org)
  • In vivo Matrigel plug assay for angiogenesis, the inclusion of 1 nM apelin in the Matrigel resulted in clear capillary-like formations with an increase of hemoglobin content in the plug. (nih.gov)
  • Despite the multiple steps involved in HIF activation, we demonstrate that peptides from two regions of the ODD not only stabilize HIFα but produce a transcriptional response that modulates angiogenesis and metabolism in vivo , suggesting that the peptides affect mechanisms that are common to all activation steps, or that when HIFα chains are present in large excess mechanisms inhibiting transcriptional activation ( 9 , 19 ) become saturated. (pnas.org)
  • Methods for using modulating agents to enhance or inhibit claudin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. (justia.com)
  • Inhibition of PDGF receptors has been shown to inhibit angiogenesis, tumor vascular maturation and maintenance, and tumor cell proliferation - inducing tumor regression. (clinicaltrials.gov)
  • Whilst requiring consistency and care, this murine model does not involve complicated surgical techniques and allows for the robust testing of promising agents that may, for example, promote angiogenesis or inhibit inflammation. (jove.com)
  • Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. (bioportfolio.com)
  • Proteins that specifically inhibit the growth of new blood vessels (ANGIOGENESIS, PHYSIOLOGIC). (bioportfolio.com)
  • EXPERIMENTAL APPROACH: Anti-angiogenic activities of S-NSAIDS, S-valproate, and the respective parent compounds were assessed using umbilical vein endothelial cells, muscle and tumor tissue explant angiogenesis assays, and developmental angiogenesis in Fli:EGFP transgenic zebrafish embryos. (bvsalud.org)
  • Here we show that EM011 (9-bromonoscapine), a microtubule-modulating agent, inhibits a spectrum. (oup.com)
  • One such agent, silibinin, inhibits the growth of various cancer cell lines and primary tumors in several chemically induced rodent models, including mouse lung ( 3 - 7 ). (aacrjournals.org)
  • In addition, this agent inhibits both the extrinsic and intrinsic coagulation cascades, preventing blood clot formation. (newyorkoncology.com)
  • In this review, the main mechanisms involved in the physiological regulation of vasculogenesis and angiogenesis are addressed. (intjmorphol.com)
  • Angiogenesis is a physiological process implicated in growth, invasion and metastization of tumors. (frontiersin.org)
  • Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). (bioportfolio.com)
  • Therapeutic angiogenesis, which supplements insufficient physiological angiogenesis, may be a therapeutic approach for ischemic conditions. (cdc.gov)
  • Angiogenesis, with a prominent role in tumor growth, is a physiological process through which new blood vessels are generated from pre-existing vasculature. (inria.fr)
  • Apicidin inhibited serum-induced cell migration, and modulated profiling of expression of genes encoding pro-oxidant and antioxidant enzymes. (bvsalud.org)
  • Mahmud T. Hassan Khan and Arjumand Ather, " Molecules from Nature: Modulating the Expression of Estrogen Receptor Genes in Breast Cancer Cells", Current Bioactive Compounds (2006) 2: 143. (eurekaselect.com)
  • However, the results of clinical trials evaluating the efficacy of modulators of angiogenesis in the treatment of cancer, macular degeneration, and cardiovascular disease suggest that more precisely targeted therapies are needed to improve the therapeutic regulation of angiogenesis in the treatment of angiogenesis-associated diseases ( 71 ). (asm.org)
  • The list of endogenous modulators of angiogenesis is growing and can offer additional and important tool for the generation of therapies to restrain tumor vascularization. (northwestern.edu)
  • With cell uptake much higher in tumor cells compared to normal cells, the F18 moiety of fluorodeoxygalactose F-18 can be visualized upon PET imaging and this agent can be used as a tracer for the evaluation of galactose tumor uptake and metabolism. (cancer.gov)
  • Radiolableled amino acid-based agents are useful in PET brain tumor imaging because F-18 fluoro-deoxyglucose (F-18 FDG), commonly used in PET tumor imaging, is relatively insensitive for detecting tumors in the brain due the high levels of glycolytic metabolism in the normal cortex and to a lesser extent in white matter. (cancer.gov)
  • An agent that modulates the physiologic angiogenesis process. (ebi.ac.uk)
  • Agents that induce or stimulate the PHYSIOLOGIC ANGIOGENESIS process. (bioportfolio.com)
  • Agents that modulate the PHYSIOLOGIC ANGIOGENESIS process. (bioportfolio.com)
  • Angiogenesis might be modulated by inflammation. (bioportfolio.com)
  • In view of the current knowledge the author will show that these S100-proteins are reliable clinical parameters as well as attractive targets to modulate inflammation. (eurekaselect.com)
  • AnxA1 2-26 ) on heterologous skin scaffolds transplantation in BALB/c mice, focusing on inflammation and angiogenesis. (frontiersin.org)
  • Angiogenesis plays a fundamental role in embryonic development, tissue and wound repair, resolution of inflammation, and onset of neoplasia. (thefreedictionary.com)
  • Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effecter function of CD8þ T cells. (springer.com)
  • Angiogenesis plays a central role in the progression of breast cancer. (cancernetwork.com)
  • Angiogenesis is a critical step in the progression of almost all human malignancies and some other life-threatening diseases. (bioportfolio.com)
  • Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. (nih.gov)
  • Peptidases and peptidase cascades have recently emerged as important regulators of angiogenesis ( 7 , 8 , 20 , 41 , 54 , 61 , 68 , 80 , 81 ) where new blood vessels are formed from existing vessels ( 31 ). (asm.org)
  • The workflow is successfully showcased on the basis of a series of matrigel images generated for the evaluation of angiogenesis inhibition compounds, and results are cross-validated with a manual expert scoring. (inria.fr)
  • PDGFR-α and -β are important new targets in tumor cell proliferation and angiogenesis. (clinicaltrials.gov)
  • By splinting the wound, the repair process is then dependent on epithelialization, cellular proliferation and angiogenesis, which closely mirror the biological processes of human wound healing. (jove.com)
  • However, many key signaling molecules involved in angiogenesis may be deregulated by Hsp90 inhibition, providing an additional benefit of Hsp90-targeted therapy. (aacrjournals.org)
  • This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents. (ebi.ac.uk)
  • Reflecting the increased amino acid transport capacity of tumor cells, F-18 fluroethyltyrosine (F-18 FET) is actively taken up in tumor cells via amino acid transport system L, but is neither incorporated into proteins nor readily degraded, resulting in high intracellular concentrations of this imaging agent. (cancer.gov)
  • The angiopoietin-like 4 (ANGPTL4) protein belongs to a superfamily of secreted proteins structurally related to factors modulating angiogenesis known as angiopoietins. (hindawi.com)
  • Although Flt-1 and KDR/Flk-1 receptors both appear to be involved in angiogenesis, their respective roles in this process are only partially elucidated. (aacrjournals.org)
  • TNP-470) with therapeutic agents that modulate steroid receptors (e.g. (farmabrasilis.org.br)
  • In summary, P-MAPA acts on androgen receptors and also blocks angiogenesis in an animal model for study of bladder cancer. (farmabrasilis.org.br)
  • 9. continued) Patients who receive irinotecan for non-therapeutic purposes unrelated to this study (such as presurgically for obtaining pharmacology data for the agent) will be eligible to enter the study provided they have recovered from the toxic effects of the agent if any. (comparetrials.com)
  • Therapeutic angiogenesis refers to strategies of inducing angiogenesis to treat diseases involving ischemic conditions. (cdc.gov)
  • In this review, we propose the clinical application of therapeutic angiogenesis for the treatment of pediatric ischemic retinopathy, including retinopathy of prematurity, familial exudative retinopathy, and NDP -related retinopathy. (cdc.gov)
  • Various molecules and modalities can be utilized to apply therapeutic angiogenesis for the treatment of ischemic retinopathy, as in coronary and peripheral artery diseases. (cdc.gov)
  • Angiogenesis, the formation of new vessels from preexisting vascular structures, is present during development, for example during embryogenesis, menstruation, and wound healing after tissue damage. (arvojournals.org)
  • The aim of this study was to investigate whether PDRN could improve peripheral tissue oxygenation and angiogenesis in diabetic foot ulcers. (bvsalud.org)
  • Given that adipose tissue expansion and transformation require active growth of new blood vasculature, angiogenesis offers a potential target for the treatment of obesity-associated disorders. (pnas.org)
  • In this system, released Rosi promotes both transformation of white adipose tissue (WAT) into brown-like adipose tissue and angiogenesis, which facilitates the homing of targeted NPs to adipose angiogenic vessels, thereby amplifying their delivery. (pnas.org)
  • We show that i.v. administration of these NPs can target WAT vasculature, stimulate the angiogenesis that is required for the transformation of adipose tissue, and transform WAT into brown-like adipose tissue, by the up-regulation of angiogenesis and brown adipose tissue markers. (pnas.org)
  • The present invention relates generally to methods for regulating claudin-mediated processes, and more particularly to the use of modulating agents comprising a claudin cell adhesion recognition sequence and/or an antibody that specifically recognizes such a sequence for inhibiting functions such as cell adhesion and the formation of tissue permeability barriers. (justia.com)
  • tumor angiogenesis the induction of the growth of blood vessels from surrounding tissue into a tumor by a diffusible protein factor released by the tumor cells. (thefreedictionary.com)
  • Angiogenesis is necessary so that a growing or enlarging tissue, with its increasing metabolic needs, obtains an adequate blood supply providing oxygen, nutrients and waste drainage. (thefreedictionary.com)
  • In one embodiment, antiproliferative, antineoplastic, angiogenic, antiangiogenic, anti-inflammatory, and/or antirestenotic agents are delivered to the wall of a blood vessel and antithrombotic agents, antiplatelet agents, and/or vasodilators are delivered to the lumen of a blood vessel. (google.es)
  • Uncontrolled tumor cell proliferation and new blood vessel formation (angiogenesis) are two major targets in the current cancer therapeutics. (aacrjournals.org)
  • Uptake of this agent depends upon the ER status of target tissues. (cancer.gov)
  • Angiogenesis also occurs in the healthy body for healing of wounds and restoring blood flow to tissues after injury. (thefreedictionary.com)
  • This work presents a continuous model for three early stage events in angiogenesis: initiation, sprout extension, and vessel maturation. (aimsciences.org)
  • L. Arakelyan, V. Vainstein and Z. Agur, A computer algorithm describing the process of vessel formation and maturation, and its use for predicting the effects of anti-angiogenic and anti-maturation therapy on vascular tumor growth ,, Angiogenesis , 5 (2002), 203. (aimsciences.org)
  • Apart from the crucial functions of the vessels, excessive vascular growth with angiogenesis can lead to undesirable conditions such as allograft rejection after organ transplantation and growth of tumors beyond the limits of oxygen diffusion from the existing vasculature. (arvojournals.org)
  • The transmembrane peptidase prostate-specific membrane antigen (PSMA) is universally upregulated in the vasculature of solid tumors, but its functional role in tumor angiogenesis has not been investigated. (asm.org)
  • Over the past few decades, many mediators of angiogenesis have been characterized, providing new and important targets for drug discovery research. (aacrjournals.org)
  • Therefore, elucidating the specific mechanisms governing angiogenesis will facilitate the identification of potential new targets for therapy. (asm.org)
  • The chemotherapy drug resistance and non-selectivity toward targets have turned the current cancer research on to the highly emerging selective targets for the development of potential anticancer agents. (intechopen.com)
  • We also discuss the therapeutic implications of recent findings that specific myeloid cell populations modulate the responses of tumours to agents such as chemotherapy and some anti-angiogenic therapies. (nih.gov)
  • TUMOURS need angiogenesis to provide the nutrients and oxygen for development and METASTATIS . (thefreedictionary.com)
  • Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. (nih.gov)
  • The Cultrex® In Vitro Angiogenesis Assay Tube Formation Kit is designed to interrogate endothelial assembly in response to compounds and soluble factors. (trevigen.com)
  • During the course of the assay, endothelial cells are seeded on a thick gel of Basement Membrane Extract in the presence of angiogenesis modulating agents. (trevigen.com)
  • Injection of tat -HIF polypeptides in a murine sponge angiogenesis assay causes a markedly accelerated local angiogenic response and induction of glucose transporter-1 gene expression. (pnas.org)
  • The effect of angiogenesis inhibition test agents to cell differentiation can be evaluated using the matrigel differentiation assay, an environment simulating in vitro the natural angiogenic process under study. (inria.fr)
  • Strikingly different angiogenic properties of endothelial progenitor cell subpopulations: insights from a novel human angiogenesis assay. (nih.gov)
  • The in-vitro study also revealed that the angiogenesis, migration, and proliferation abilities of EPCs and the number of senescent EPCs were reversed by curcumin application. (biomedcentral.com)
  • In addition, angiogenesis, migration, proliferation abilities, and senescence were determined in EPCs isolated from diabetic and nondiabetic mice. (biomedcentral.com)
  • This is the first report to describe a previously unrecognized, antiangiogenic property of a noscapinoid, EM011, and provides evidence for novel anticancer strategies recruited by microtubule-modulating drugs. (oup.com)
  • Xanthohumol is a prenylated chalcone naturally found in hop plants, previously reported to be an effective anticancer agent in various cancer cell lines. (hindawi.com)
  • Therefore, it would lead to providing a path for the development of novel target-specific and highly effective benzimidazole-based anticancer agents. (intechopen.com)
  • The critical contribution of this angiogenic factor in controlling many of the processes involved in angiogenesis and its importance as a paradigm for the rational design of an anticancer agent have been among the successes of antiangiogenic treatment, which was first suggested by Judah Folkman more than 35 years ago. (biomedcentral.com)
  • Conclusively our results strongly suggest that withaferin A is a potent anticancer agent as ascertained by its potent Hsp90-client modulating capability. (agscientific.com)
  • Angiogenesis contributes to malignancy by providing the necessary oxygenation and nutritional supplement for the tumour's growth and invasion. (usp.br)
  • At present there are no data available as to its possible influence on tumor angiogenesis, which is a major biological mechanism responsible for tumor growth and dissemination. (ovid.com)
  • Angiogenesis plays an important role in the growth and spread of cancer. (thefreedictionary.com)
  • A major protein involved in regulating the differentiation and proliferation of vascular endothelial cells thus promoting the growth of new blood vessels ( angiogenesis ). (thefreedictionary.com)
  • The invention relates to a use of an aurantiamide dipepetide derivative in the treatment or prevention of angiogenesis-related diseases. (patents.com)
  • Studies cytokines as natural agents for modulating diseases t. (infibeam.com)
  • These findings suggest that angiogenesis-targeting moieties with angiogenic stimulator-loaded NPs could be incorporated into effective therapeutic regimens for clinical treatment of obesity and other metabolic diseases. (pnas.org)
  • A drug delivery device is provided with openings for directional delivery of a plurality of therapeutic agents to blood vessels or other lumens or organs. (google.es)
  • On the other hand, the processes of remodeling and postnatal vascular proliferation are generated through the formation of new vessels from pre-existing vessels (angiogenesis). (intjmorphol.com)
  • Angiogenesis, the formation of new blood vessels, is required early on in tumor development. (aacrjournals.org)
  • Decreased production of angiogenesis factors may occur as a result of EGFR inhibition. (thefreedictionary.com)
  • This E-Update will focus on the role of angiogenesis in breast cancer and the impact of antiangiogenic therapy in the treatment of advanced breast cancer. (cancernetwork.com)
  • It is hypothesized that other anti-angiogenic agents such as endostar, may augment the effect of chemotherapy regimens in CRC. (clinicaltrials.gov)
  • There are many approaches to the treatment of MBC, including chemotherapy agents, hormonal therapies, biologics, and supportive care. (cancernetwork.com)
  • The transcriptional regulation of ANGPTL4 can be modulated by several transcription factors, including PPAR α , PPAR β / δ , PPAR γ , and HIF-1 α , and nutritional and hormonal conditions. (hindawi.com)
  • The effects of chemopreventive agents at the gene transcriptional level are poorly understood ( 7 ). (aacrjournals.org)