Angiogenesis modulating agents. Medical search

A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.

The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.

Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.

A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.

These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.

A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.

Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.

Agents that modulate the PHYSIOLOGIC ANGIOGENESIS process. This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety of other chemicals and pharmaceutical agents.

Endothelial cells that line venous vessels of the UMBILICAL CORD.

The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

A highly vascularized extra-embryonic membrane, formed by the fusion of the CHORION and the ALLANTOIS. It is mostly found in BIRDS and REPTILES. It serves as a model for studying tumor or cell biology, such as angiogenesis and TISSUE TRANSPLANTATION.

The minute vessels that connect the arterioles and venules.

A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).

An extra-embryonic membranous sac derived from the YOLK SAC of REPTILES; BIRDS; and MAMMALS. It lies between two other extra-embryonic membranes, the AMNION and the CHORION. The allantois serves to store urinary wastes and mediate exchange of gas and nutrients for the developing embryo.

Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.

New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.

An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.

The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.

Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.

A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A cell line derived from cultured tumor cells.

The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.

Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)

The finer blood vessels of the vasculature that are generally less than 100 microns in internal diameter.

Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.

The circulation of the BLOOD through the MICROVASCULAR NETWORK.

An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).

Experimental transplantation of neoplasms in laboratory animals for research purposes.

Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.

Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.

Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.

Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Restoration of integrity to traumatized tissue.

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.

Six-carbon alicyclic hydrocarbons.

Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity.

Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

Transplantation between animals of different species.

Glycoproteins which have a very high polysaccharide content.

Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

A condition of decreased oxygen content at the cellular level.

The blood vessels which supply and drain the RETINA.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

The formation of LYMPHATIC VESSELS.

A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.

Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

Proteins that specifically inhibit the growth of new blood vessels (ANGIOGENESIS, PHYSIOLOGIC).

The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)

A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.

Ability of neoplasms to infiltrate and actively destroy surrounding tissue.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.

Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

Relatively complete absence of oxygen in one or more tissues.

A basic helix-loop-helix transcription factor that plays a role in APOPTOSIS. It is composed of two subunits: ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR and HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT.

A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.

Elements of limited time intervals, contributing to particular results or situations.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.

Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

Adherence of cells to surfaces or to other cells.

Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

An enzyme that catalyzes the transfer of 2-deoxy-D-ribose from THYMIDINE to orthophosphate, thereby liberating thymidine.

Compounds that inhibit the enzyme activity or activation of MATRIX METALLOPROTEINASES.

Dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and axonal guidance. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS, and binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Processes required for CELL ENLARGEMENT and CELL PROLIFERATION.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells.

The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

Established cell cultures that have the potential to propagate indefinitely.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.

A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

The main trunk of the systemic arteries.

The movement of cells or organisms toward or away from a substance in response to its concentration gradient.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Proteins prepared by recombinant DNA technology.

An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.

A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Tumors or cancer of the LUNG.

Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)

Tumors or cancer of the human BREAST.

A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.

The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.

A vascular endothelial growth factor expressed in a variety of tissues. It binds with high specificity to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 and NEUROPILIN-1.

A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.

Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.

A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.

An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Gauze material used to absorb body fluids during surgery. Referred to as GOSSYPIBOMA if accidentally retained in the body following surgery.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Receptors such as INTEGRIN ALPHAVBETA3 that bind VITRONECTIN with high affinity and play a role in cell migration. They also bind FIBRINOGEN; VON WILLEBRAND FACTOR; osteopontin; and THROMBOSPONDINS.

Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

An enzyme that catalyzes the endonucleolytic cleavage of pancreatic ribonucleic acids to 3'-phosphomono- and oligonucleotides ending in cytidylic or uridylic acids with 2',3'-cyclic phosphate intermediates. EC 3.1.27.5.

Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.

Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.

A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.

A family of proteins that mediate axonal guidance. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.

A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.

A transmembrane domain containing ephrin that binds with high affinity to EPHB1 RECEPTOR; EPHB3 RECEPTOR; and EPHB4 RECEPTOR. Expression of ephrin-B2 occurs in a variety of adult tissues. During embryogenesis, high levels of ephrin-B2 is seen in the PROSENCEPHALON; RHOMBENCEPHALON; developing SOMITES; LIMB BUD; and bronchial arches.

Signal molecules that are involved in the control of cell growth and differentiation.

Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

The flow of BLOOD through or around an organ or region of the body.

Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

Peptides composed of between two and twelve amino acids.

A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.

Tumors or cancer of the PROSTATE.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

An alpha integrin with a molecular weight of 160-kDa that is found in a variety of cell types. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds. Integrin alphaV can combine with several different beta subunits to form heterodimers that generally bind to RGD sequence-containing extracellular matrix proteins.

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.

A vascular endothelial cell growth factor receptor whose expression is restricted primarily to adult lymphatic endothelium. VEGFR-3 preferentially binds the vascular endothelial growth factor C and vascular endothelial growth factor D and may be involved in the control of lymphangiogenesis.

A malignant epithelial tumor with a glandular organization.

Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.

A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.

Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.

A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.

The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.

Antibodies produced by a single clone of cells.

Precursor of plasmin (FIBRINOLYSIN). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent.

Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.

Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

Tumors or cancer of the COLON.

An eph family receptor found in a variety of adult and embryonic tissues. Unlike the majority of proteins in this class there is little or no expression of EphB4 receptor in the BRAIN. It has been found at high levels in developing mammary glands and in invasive mammary tumors.

A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.

The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.

A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. (1/26)

Angiopoietin-1 (Ang1) has potential therapeutic applications in inducing angiogenesis, enhancing endothelial cell survival, and preventing vascular leakage. However, production of Ang1 is hindered by aggregation and insolubility resulting from disulfide-linked higher-order structures. Here, by replacing the N-terminal portion of Ang1 with the short coiled-coil domain of cartilage oligomeric matrix protein (COMP), we have generated a soluble, stable, and potent Ang1 variant, COMP-Ang1. This variant is more potent than native Ang1 in phosphorylating the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor and Akt in primary cultured endothelial cells, enhancing angiogenesis in vitro and increasing adult angiogenesis in vivo. Thus, COMP-Ang1 is an effective alternative to native Ang1 for therapeutic angiogenesis in vivo. (+info)

Current methods for assaying angiogenesis in vitro and in vivo. (2/26)

Angiogenesis, the development of new blood vessels from an existing vasculature, is essential in normal developmental processes and in numerous pathologies, including diabetic retinopathy, psoriasis and tumour growth and metastases. One of the problems faced by angiogenesis researchers has been the difficulty of finding suitable methods for assessing the effects of regulators of the angiogenic response. The ideal assay would be reliable, technically straightforward, easily quantifiable and, most importantly, physiologically relevant. Here, we review the advantages and limitations of the principal assays in use, including those for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures and in vivo assays such as sponge implantation, corneal, chamber, zebrafish, chick chorioallantoic membrane (CAM) and tumour angiogenesis models. (+info)

Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle. (3/26)

Increased skeletal muscle capillary density would be a logical adaptive mechanism to chronic hypoxic exposure. However, animal studies have yielded conflicting results, and human studies are sparse. Neoformation of capillaries is dependent on endothelial growth factors such as vascular endothelial growth factor (VEGF), a known target gene for hypoxia inducible factor 1 (HIF-1). We hypothesised that prolonged exposure to high altitude increases muscle capillary density and that this can be explained by an enhanced HIF-1alpha expression inducing an increase in VEGF expression. We measured mRNA levels and capillary density in muscle biopsies from vastus lateralis obtained in sea level residents (SLR; N=8) before and after 2 and 8 weeks of exposure to 4100 m altitude and in Bolivian Aymara high-altitude natives exposed to approximately 4100 m altitude (HAN; N=7). The expression of HIF-1alpha or VEGF mRNA was not changed with prolonged hypoxic exposure in SLR, and both genes were similarly expressed in SLR and HAN. In SLR, whole body mass, mean muscle fibre area and capillary to muscle fibre ratio remained unchanged during acclimatization. The capillary to fibre ratio was lower in HAN than in SLR (2.4+/-0.1 vs 3.6+/-0.2; P<0.05). In conclusion, human muscle VEGF mRNA expression and capillary density are not significantly increased by 8 weeks of exposure to high altitude and are not increased in Aymara high-altitude natives compared with sea level residents. (+info)

Bartonella adhesin a mediates a proangiogenic host cell response. (4/26)

Bartonella henselae causes vasculoproliferative disorders in humans. We identified a nonfimbrial adhesin of B. henselae designated as Bartonella adhesin A (BadA). BadA is a 340-kD outer membrane protein encoded by the 9.3-kb badA gene. It has a modular structure and contains domains homologous to the Yersinia enterocolitica nonfimbrial adhesin (Yersinia adhesin A). Expression of BadA was restored in a BadA-deficient transposon mutant by complementation in trans. BadA mediates the binding of B. henselae to extracellular matrix proteins and to endothelial cells, possibly via beta1 integrins, but prevents phagocytosis. Expression of BadA is crucial for activation of hypoxia-inducible factor 1 in host cells by B. henselae and secretion of proangiogenic cytokines (e.g., vascular endothelial growth factor). BadA is immunodominant in B. henselae-infected patients and rodents, indicating that it is expressed during Bartonella infections. Our results suggest that BadA, the largest characterized bacterial protein thus far, is a major pathogenicity factor of B. henselae with a potential role in the induction of vasculoproliferative disorders. (+info)

Vascular endothelial growth factor and angiogenesis. (5/26)

Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various ischemic and inflammatory diseases. A rich variety of pro- and antiangiogenic molecules have already been discovered. Vascular endothelial growth factor (VEGF) is an interesting inducer of angiogenesis and lymphangiogenesis, because it is a highly specific mitogen for endothelial cells. Signal transduction involves binding to tyrosine kinase receptors and results in endothelial cell proliferation, migration, and new vessel formation. In this article, the role of VEGF in physiological and pathological processes is reviewed. We also discuss how modulation of VEGF expression creates new therapeutic possibilities and describe recent developments in this field. (+info)

The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. (6/26)

The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular development during embryogenesis. The soluble monomeric derivative of the extracellular domain of EphB4 (sEphB4) was designed as an antagonist of EphB4/EphrinB2 signaling. sEphB4 blocks activation of EphB4 and EphrinB2; suppresses endothelial cell migration, adhesion, and tube formation in vitro; and inhibits the angiogenic effects of various growth factors (VEGF and bFGF) in vivo. sEphB4 also inhibits tumor growth in murine tumor xenograft models. sEphB4 is thus a therapeutic candidate for vascular proliferative diseases and cancer. (+info)

New insights into the biology of preeclampsia. (7/26)

Despite recent research progress, the biology of preeclampsia is still poorly understood and neither effective prediction nor causal therapy have yet emerged. Nevertheless, recent studies have documented new and exciting pathophysiological mechanisms for the origin and development of preeclampsia. These studies provide a more differentiated view on alterations of particular peptide systems with strong impact on angiogenesis and cardiovascular regulation in this pregnancy disorder. With the identification of the antiangiogenic factor soluble fms-like tyrosine kinase 1 and the agonistic autoantibody to the angiotensin II type 1 receptor, two factors have been described with a clear linkage to the development of the disease. This review focuses on the most recent and relevant insights into the biology of preeclampsia and develops hypotheses regarding possible links between the reported aspects of preeclampsia. (+info)

A cell-based model exhibiting branching and anastomosis during tumor-induced angiogenesis. (8/26)

This work describes the first cell-based model of tumor-induced angiogenesis. At the extracellular level, the model describes diffusion, uptake, and decay of tumor-secreted pro-angiogenic factor. At the cellular level, the model uses the cellular Potts model based on system-energy reduction to describe endothelial cell migration, growth, division, cellular adhesion, and the evolving structure of the stroma. Numerical simulations show: 1), different tumor-secreted pro-angiogenic factor gradient profiles dramatically affect capillary sprout morphology; 2), average sprout extension speeds depend on the proximity of the proliferating region to the sprout tip, and the coordination of cellular functions; and 3), inhomogeneities in the extravascular tissue lead to sprout branching and anastomosis, phenomena that emerge without any prescribed rules. This model provides a quantitative framework to test hypotheses on the biochemical and biomechanical mechanisms that control tumor-induced angiogenesis. (+info)

... angiogenesis modulating agents MeSH D27.505.696.377.077.077 - angiogenesis inducing agents MeSH D27.505.696.377.077.099 - ... fibrin modulating agents MeSH D27.505.519.421.500 - antifibrinolytic agents MeSH D27.505.519.421.750 - fibrinolytic agents MeSH ... lipotropic agents MeSH D27.505.954.248 - antineoplastic agents MeSH D27.505.954.248.025 - angiogenesis inhibitors MeSH D27.505. ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D27)

Targeted agents are designed to be selective in their effects by modulating the activity of proteins necessary and essential ... for oncogenesis and maintenance of cancer, particularly enzymes driving the uncontrolled growth, angiogenesis, invasiveness, ... Many targeted agents appear more active in certain NSCLC variants. Given that c-SCLC contains components of NSCLC, and that the ... Targeted agents are beginning to permit the design of more rational treatment regimens for non-small cell lung cancer (NSCLC), ...

https://en.wikipedia.org/wiki/Targeted_therapy_of_lung_cancer

... the tumor microenvironment and counteracts cancer development by inhibiting angiogenesis and metastasis and by modulating the ... by laboratories at Johns Hopkins School of Medicine and Active Biotech Research AB identified tasquinimod as the lead agent for ... Tasquinimod reduces tumor angiogenesis; but its anti-angiogenic effects do not appear to be linked to vascular endothelial ...

https://en.wikipedia.org/wiki/Tasquinimod

... thereby reducing tumor agents and increasing efficiency of electron transfer by modulating the activity of glucose oxidase. ... The process of angiogenesis involves the use of both promoters and inhibitors, balancing the process by only forming new blood ... As AuNPs reduce angiogenesis, rheumatoid arthritis is reduced as a result. Chamberland et al studied the use of anti-TNF ... The issue of angiogenesis describes the formation of new blood vessels, which not only increased spread of cancerous cells, but ...

https://en.wikipedia.org/wiki/Gold_nanoparticles_in_chemotherapy

A key step forward in 1993 was the identification of the NF2 gene and its protein product Merlin, which modulates the complex ... A second important field of study in molecular biology investigates ways to stop the formation (angiogenesis) of the new blood ... such as tumor suppressing agents." Ideally, a drug could be found to permanently shrink or eradicate VSs, with minimal side ... angiogenesis) needed for tumor growth. Tumors may swell following radiation, but this increase in size is transient and does ...

https://en.wikipedia.org/wiki/Vestibular_schwannoma

For example, the Hsp90 inhibitor geldanamycin has been used as an anti-tumor agent. The drug was originally thought to function ... Together with its co-chaperones, Hsp90 modulates tumour cell apoptosis "mediated through effects on AKT, tumor necrosis factor ... angiogenesis, and metastasis. Hsp90 plays apparently conflicting roles in the cell, as it is essential for both the creation ... Both are important for de novo angiogenesis that is required for tumour growth beyond the limit of diffusion distance of oxygen ...

https://en.wikipedia.org/wiki/Hsp90

These mosquito eaters have been used in the past as mosquito control agents, with varying success. Many, if not all, blood- ... It is now well recognized that feeding ticks, sandflies, and, more recently, mosquitoes, have an ability to modulate the immune ... Mosquito saliva acts to reduce vascular constriction, blood clotting, platelet aggregation, angiogenesis and immunity, and ... Zeidner NS, Higgs S, Happ CM, Beaty BJ, Miller BR (January 1999). "Mosquito feeding modulates Th1 and Th2 cytokines in ...

https://en.wikipedia.org/wiki/Mosquito

In 1977, the growth modulating peptide was shown to be a glycyl-L-histidyl-L-lysine. It is proposed that GHK-Cu modulates ... In the late 1980s, copper peptide GHK-Cu started attracting attention as a promising wound healing agent. At picomolar to ... angiogenesis, and wound closure in both wound chambers and full thickness wounds. In one study, full‐thickness wounds of 6 ... Thus, GHK-Cu's ability to bind copper and to modulate its tissue level is a key factor determining its biological activity. " ...

https://en.wikipedia.org/wiki/Copper_peptide_GHK-Cu

In addition, S1P modulates the proliferation of skin cells. This in particular applies to keratinocytes while fibroblasts are ... Administration of S1P has been shown to protect oocytes from chemotherapeutic agents in vitro, as well as in vivo from ... In the vascular system, S1P regulates angiogenesis, vascular stability, and permeability. In the immune system, it is now ... angiogenesis. Given its role in creating new blood vessels, scientists recognize S1P as vital to human health - and a player in ...

https://en.wikipedia.org/wiki/Sphingosine-1-phosphate

Sequential single agent chemotherapy may have a more positive effect on progression-free survival. Taxanes are very active in ... TNC is an adhesion-modulating extracellular matrix glycoprotein. It is highly expressed in tumor stroma and stimulates tumor- ... Heparanase expressed by cancer cells participates in angiogenesis and neovascularization by degrading the polysaccharide ... MMP-2 is unlike other MMP's as its activity is modulated by metalloproteases called tissue inhibitor of metalloproteases (TIMP ...

https://en.wikipedia.org/wiki/Metastatic_breast_cancer

ROS have been shown to induce transcription factors and modulate signaling molecules involved in angiogenesis (MMP, VEGF) and ... The role of ROS in promoting tumor proliferation is further supported by the observation that agents with potential to inhibit ... In fact, most of the chemotherapeutic and radiotherapeutic agents kill cancer cells by augmenting ROS stress. The ability of ... Due to the dual role of ROS, both prooxidant and antioxidant-based anticancer agents have been developed. However, modulation ...

https://en.wikipedia.org/wiki/Reactive_oxygen_species

... the drugs in metronomic therapy suppress tumor growth mainly by inhibiting tumor angiogenesis and modulating the immune ... However, the side effects are often significant as the cytotoxic agents also kill the fast-dividing cells normally present in ... Angiogenesis supports tumor growth by ensuring sufficient oxygen and nutrient supply to the rapidly-proliferating tumor cells. ... In his commentary on two animal studies testing the effects of metronomic dosing of chemotherapeutic agents on tumor growth, he ...

https://en.wikipedia.org/wiki/Metronomic_therapy

All interferons share several common effects: they are antiviral agents and they modulate functions of the immune system. ... Interferons can also suppress angiogenesis by down regulation of angiogenic stimuli deriving from tumor cells. They also ... Stringfellow D, Glasgow L (1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrob Agents Chemother. 2 ( ... Unconfirmed results suggested that the combination of interferon and an antiviral agent may speed the healing process compared ...

https://en.wikipedia.org/wiki/Interferon

... angiogenesis, and tissue regeneration. Microvesicles may also remove misfolded proteins, cytotoxic agents and metabolic waste ... Microparticles derived from monocytes aggravate atherosclerosis by modulating inflammatory cells. Additionally, microvesicles ... Angiogenesis, which is essential for tumor survival and growth, occurs when endothelial cells proliferate to create a matrix of ... Microvesicles play an important role in tumor angiogenesis and in the degradation of matrix due to the presence of ...

https://en.wikipedia.org/wiki/Microvesicles

Cao, Yihai (2007-09-01). "Angiogenesis modulates adipogenesis and obesity". The Journal of Clinical Investigation. 117 (9): ... "Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome". ... "Angiogenesis in Obesity & Diabetes , School of Medicine". medicine.dundee.ac.uk. Retrieved 2017-02-22. "Axel Hirsch Prize for ... Cao, Y.; Chen, C.; Weatherbee, J. A.; Tsang, M.; Folkman, J. (1995-12-01). "gro-beta, a -C-X-C- chemokine, is an angiogenesis ...

https://en.wikipedia.org/wiki/Yihai_Cao

Inhibition of angiogenesis including VEGFR-2 inhibitors has been of much interest and research in recent decades because ... The urea derivatives block the VEGFR and/or one or more protein kinases and can therefore modulate, regulate and/or inhibit ... Generally it is well tolerated and safe but can have adverse effects which can be intensified by chemotherapeutic agents used ... Sorafenib is used as an oral drug which inhibits angiogenesis and tumor cell growth in VEGFR-2 and VEGFR-3 (inhibits the ...

https://en.wikipedia.org/wiki/VEGFR-2_inhibitor

... also helps promote angiogenesis. The roles of galectins and galectin-3, in particular, in cancer have been heavily ... Galectin-3 associates with the primary cilium and modulates renal cyst growth in congenital polycystic kidney disease. The ... targeting the actions of galectin-3 poses a promising therapeutic strategy for the development of effective therapeutic agents ... December 2006). "Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney ...

https://en.wikipedia.org/wiki/Galectin-3

It modulates the immune response to atherosclerosis, of which obesity is a predisposing and exercise a mitigating factor. ... Exogenous leptin can promote angiogenesis by increasing vascular endothelial growth factor levels. Hyperleptinemia produced by ... There are nutritional supplements and pharmacological agents capable of directing these factors and improving both conditions.[ ... Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI (August 1998). "Leptin modulates the T-cell immune response and ...

https://en.wikipedia.org/wiki/Leptin

DG-041, a highly selective EP3 antagonist, has been proposed to warrant further study as anti-thrombosis agent. GR 63799X, MB- ... Takeuchi K, Kato S, Amagase K (2010). "Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity". ... and a tumor-associated angiogenesis and lymphangiogenesis. Many drugs that act on EP3 and, often, other prostaglandin receptors ...

https://en.wikipedia.org/wiki/Prostaglandin_EP3_receptor

... metabolism of various foreign agents to carcinogens has been implicated in the formation of various types of human ... Additionally, the tumour suppressor p53 has been shown to impact CYP1A1 expression thereby modulating the metabolic activation ... Zhang G, Kodani S, Hammock BD (Jan 2014). "Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and ... inhibit angiogenesis, endothelial cell migration and endothelial cell proliferation; and inhibit the growth and metastasis of ...

https://en.wikipedia.org/wiki/CYP1A1

Its intracellular signalling cascades are responsible for modulating cell activity rather towards higher active state as in ... immunoglobulins or infectious agents. CX3CL1-CX3CR1 axis' signalling commences via activation of the receptor by its agonist's ... axis between endothelial cells and monocytes is responsible for formation of extracellular matrix and angiogenesis. It was ... where CX3CL1-CX3CR1 axis is a double agent, providing antitumoral effects (stimulating and recruiting immune cells to target ...

https://en.wikipedia.org/wiki/CX3CR1

In catalyzing the synthesis of thromboxanes, TXA synthase is involved in a flux pathway that can modulate the amount of ... Ratti S, Quarato P, Casagrande C, Fumagalli R, Corsini A (August 1998). "Picotamide, an antithromboxane agent, inhibits the ... angiogenesis, and metastasis. Thromboxane synthesis Eicosanoid synthesis Prostanoid 12-Hydroxyheptadecatrienoic acid GRCh38: ...

https://en.wikipedia.org/wiki/Thromboxane-A_synthase

Gα12 and Gα13 modulate cytoskeletal remodeling and cell-shape changes and Gαq modulates several cellular effector functions. ... It was also shown in vivo that S1P synergizes with angiogenic factors such as FGF-2 and VEGF in inducing angiogenesis and ... Fingolimod, a drug which internalizes the receptor, is approved as a disease modifying agent in MS. There are other Sphingosine ... Depending on the G protein coupled with the S1PR1, diverse cellular effects are achieved: Gαi and Gαo modulate cellular ...

https://en.wikipedia.org/wiki/S1PR1

As described above in mechanisms of tumor evasion, the tumor cells are modulating the immune response in their profit. It is ... The researchers report that when killing cancer cells with this agent uptake and presentation by antigen presenting dendritic ... promotion of tumor growth and angiogenesis. Tumor cells have non-classical MHC class I on their surface, for example HLA-G. HLA ...

https://en.wikipedia.org/wiki/Cancer_immunology

Wolf A, Herb M, Schramm M, Langmann T (June 2020). "The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis ... TSPO ligands (endogenous or synthetic) modulate the action of this receptor, activating the transport of cholesterol from the ... December 2007). "The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic ... Tanimoto Y, Onishi Y, Sato Y, Kizaki H (February 1999). "Benzodiazepine receptor agonists modulate thymocyte apoptosis through ...

https://en.wikipedia.org/wiki/Translocator_protein

Lessons learned from the successes and failures of siderophore-conjugate drugs evaluated during the development of novel agents ... and modulating the responses of dendritic cells and cells of the adaptive immune response. Animal models indicate that host ... and angiogenesis modulation. These immunomodulatory effects have only recently begun to receive attention. Several methods have ... Antimicrobial peptides have been used as therapeutic agents; their use is generally limited to intravenous administration or ...

https://en.wikipedia.org/wiki/Antimicrobial_peptides

These effects are modulated by the P2RY1 and the P2Y12 receptors. The P2RY1 receptor is responsible for shape change in ... Like most immunomodulating agents, ATP can act either as an immunosuppressive or an immunostimulatory factor, depending on the ... Adenosine receptors affect bronchial reactivity, endothelial permeability, fibrosis, angiogenesis and mucus production. ... Extracellular purines modulate fibroblast proliferation by binding onto adenosine receptors and P2 receptors to influence ...

https://en.wikipedia.org/wiki/Purinergic_signalling

Norrby K (1995). "Evidence of a dual role of endogenous histamine in angiogenesis". Int J Exp Pathol. 76 (2): 87-92. PMC ... Consequently, unlike the H1-antihistamines which are sedating, H3-antihistamines have stimulant and cognition-modulating ... Anti-Allergy Agents. Bentham Science Publishers. pp. 31-. ISBN 978-1-68108-337-7. Walter Sneader (31 October 2005). Drug ... Histamine also promotes angiogenesis. Antihistamines suppress the histamine-induced wheal response (swelling) and flare ...

https://en.wikipedia.org/wiki/Antihistamine

... modulating agents and structure-function relationships". Expert Review of Proteomics. 9 (2): 181-99. doi:10.1586/epr.12.12. ... June 2016). "Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts ... October 2011). "ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin ... ANGPTL4 plays an important role in numerous cancers and is implicated in the metastatic process by modulating vascular ...

https://en.wikipedia.org/wiki/ANGPTL4

Abrogates Cancer Cell Invasion and Angiogenesis by Modulating Extracellular Par-4". PLOS ONE. 7 (9): e44039. Bibcode:2012PLoSO ... Therefore, withaferin A can be a potential therapeutic agent for the treatment of cervical cancer without major side effects. ... 2004). "Withaferin A is a potent inhibitor of angiogenesis". Angiogenesis. 7 (2): 115-122. doi:10.1007/s10456-004-1026-3. PMID ... It is a potent inhibitor of angiogenesis. Anti-angiogenic and anti-tumor activity of withaferin A is due to the inhibition of ...

https://en.wikipedia.org/wiki/Withaferin_A

It has been observed that it not only induces apoptosis but can also inhibit the cell cycle, and has marked anti-angiogenesis ... Arsenic is a fairly ancient human therapeutic agent, however it has only recently returned to the forefront of cancer treatment ... "Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and ... HSCs secrete angiopoietin, and its receptor molecule Tie2 has been implicated in angiogenesis of tumors in both humans and mice ...

https://en.wikipedia.org/wiki/MECOM

These effects can all modulate the transcription of genes. Deubiquitinating enzymes (DUBs) oppose the role of ubiquination by ... Dou QP, Li B (August 1999). "Proteasome inhibitors as potential novel anticancer agents". Drug Resistance Updates. 2 (4): 215- ... HIF activates downstream targets such as the vascular endothelial growth factor (VEGF), promoting angiogenesis. Mutations in ... Vries EG, Verweij J (2000). "Clinical Cancer Research 2000: New Agents and Therapies". Drug Resistance Updates. 3 (4): 197-201 ...

https://en.wikipedia.org/wiki/Ubiquitin

While lipid tails primarily modulate bilayer phase behavior, it is the headgroup that determines the bilayer surface chemistry ... Because tumors induce rapid and uncontrolled angiogenesis they are especially "leaky" and allow liposomes to exit the ... "Negative Staining of Phospholipids and Their Structural Modification by Surface-Active Agents As Observed in the Electron ... One particularly important component of many mixed phase systems is cholesterol, which modulates bilayer permeability, ...

https://en.wikipedia.org/wiki/Lipid_bilayer

Cells treated with Azad, a demethylating agent, grow much slower than cells cultured in the absence of Azad. At the same time, ... migration and angiogenesis in tumorigenesis. Lottin et al. also found that the overexpression of H19 positively regulates post- ... "Steroid hormones modulate H19 gene expression in both mammary gland and uterus". Oncogene. 18 (31): 4460-4473. doi:10.1038/sj. ...

https://en.wikipedia.org/wiki/H19_(gene)

The agents that are competent to edit genetic codes are viruses or subviral RNA-agents. Although GEEN has higher efficiency ... It has been demonstrated that this strategy can be used to promote a process of angiogenesis in animals. It is also possible to ... The CRISPR-Cas9 system can be programmed to modulate the population of any bacterial species by targeting clinical genotypes or ... Carroll D (November 2008). "Progress and prospects: zinc-finger nucleases as gene therapy agents". Gene Therapy. 15 (22): 1463- ...

https://en.wikipedia.org/wiki/Genome_editing

Angiogenesis (blood vessel formation) is an essential part of the formation of large tumour masses. Angiogenesis can be ... becoming the first approved oncolytic agent in the western world. It is based on herpes simplex virus (HSV-1). It has also been ... "VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells". Molecular Therapy. 21 (5 ... The anti-angiogenesis drug Bevacizumab (anti-VEGF antibody) has been shown to reduce the inflammatory response to oncolytic HSV ...

https://en.wikipedia.org/wiki/Oncolytic_virus

These agents have several theoretical advantages over current therapy. They may be given orally. They have rapid onset of ... Sinha U, Wolf DL (February 1993). "Carbohydrate residues modulate the activation of coagulation factor X". The Journal of ... angiogenesis and atherosclerosis. Inhibition of the synthesis or activity of Factor X is the mechanism of action for many ... These agents known as vitamin K antagonists (VKA), inhibit the vitamin K-dependent carboxylation of Factors II (prothrombin), ...

https://en.wikipedia.org/wiki/Factor_X

For example, Zebularine, a demethylating agent, could be used to remove the methyl groups from the CpGs of the dlc1 promoter, ... Shih YP, Liao YC, Lin Y, Lo SH (2010). "DLC1 negatively regulates angiogenesis in a paracrine fashion". Cancer Research. 70 (21 ... Fidyk N, Wang JB, Cerione RA (Jun 2006). "Influencing cellular transformation by modulating the rates of GTP hydrolysis by ... As of 2010, current research indicates DLC1 negatively regulates angiogenesis in a paracrine fashion. This is by upregulation ...

https://en.wikipedia.org/wiki/DLC1

Choi S, Park S (September 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 ... Knowing which pathways involve Fyn will provide key insight for the development of potential pharmacologic agents to attenuate ... angiogenesis, and development of metastasis," all hallmarks of cancer progression. Fyn's normal function in cellular growth and ...

https://en.wikipedia.org/wiki/FYN

Altieri DC (November 1994). "Splicing of effector cell protease receptor-1 mRNA is modulated by an unusual retained intron". ... After, they tested resveratrol in combination with several different known anticancer agents. They found a consistent increase ... whereby mice given the vaccine had less angiogenesis from the tumour challenge than the control mice that were not given any of ... Altieri DC (1994). "Splicing of effector cell protease receptor-1 mRNA is modulated by an unusual retained intron". ...

https://en.wikipedia.org/wiki/Survivin

The isolated infectious agent was later called Sendai virus, which was used interchangeably with the name "Hemagglutinating ... By down regulation of angiogenic stimuli produced by tumor cells interferon can also suppress angiogenesis In addition, they ... "Longer and shorter forms of Sendai virus C proteins play different roles in modulating the cellular antiviral response". ... V. Senin and his team as an anticancer agent in a few dozen patients affected by various malignancies with metastatic growth in ...

https://en.wikipedia.org/wiki/Murine_respirovirus

In food manufacturing, it is used as a flavoring agent. In humans, butyric acid is one of two primary endogenous agonists of ... More recently, it has been shown that butyrate plays an essential and direct role in modulating gene expression of cytotoxic T- ... October 2008). "Butyrate-induced phosphatase regulates VEGF and angiogenesis via Sp1". Archives of Biochemistry and Biophysics ... Agents Chemother. 55 (6): 2897-904. doi:10.1128/AAC.00016-11. PMC 3101455. PMID 21464244. Zimmerman MA, Singh N, Martin PM, ...

https://en.wikipedia.org/wiki/Butyric_acid

Niacinamide, the active form of vitamin B3, acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby ... Release of lactate from tumor cells through MCT-4 was sufficient to stimulate angiogenesis and tumor growth through an IL-8- ... Hyaluronan is a glycosaminoglycan polymer critical for maintaining extracellular matrix integrity and modulating cell-cell ... The hypoxic zones of tumors generally evade traditional chemotherapeutic agents and ultimately contribute to relapse. In the ...

https://en.wikipedia.org/wiki/Tumor_hypoxia

Processes associated with angiogenesis, such as wound healing and reproduction, are seemingly not affected by endostatin. The ... Javaherian, K.; Park, S.Y.; Pickl, W.F.; LaMontagne, K.R.; Sjin, R.T.T.; Gillies, S.; Lo, K. (2002). "Laminin modulates ... It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. Endostatin is a broad-spectrum ... Among anti-angiogenesis inhibitors, endostatin has a wide range of anti-cancer spectrum targets, increasing its significance ...

https://en.wikipedia.org/wiki/Endostatin

Tumor angiogenesis rely on interactions between endothelial vascular growth factors which can all activate the PI3K/AKT/mTOR in ... The response rate in solid tumors where rapalogs have been used as a single-agent therapy have been modest. Due to partial mTOR ... October 2012). "Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive ... Tumors that depend on PI3K/mTOR pathway should respond to these agents but it is unclear if compounds are effective in cancers ...

https://en.wikipedia.org/wiki/MTOR_inhibitors

Further investigation of MSCs on self-assembled monolayers showed that modulating RGD density and the affinity of RGD for αvβ3 ... One of the most extensively examined targets of angiogenesis is integrin αVβ3. Radiolabeled peptides containing RGD show high ... Kloner, Robert A. (2013-08-02). "Current State of Clinical Translation of Cardioprotective Agents for Acute Myocardial ... Design, Synthesis and Clinical Evaluation". Anti-Cancer Agents in Medicinal Chemistry. 10 (10): 753-768. doi:10.2174/ ...

https://en.wikipedia.org/wiki/Arginylglycylaspartic_acid

Waller's group wished to determine the effect of 2 - deoxyriboguanylurea (GuaUre-dR), a chemotherapeutic agent, on i-motif DNA ... has the ability to selectively modulate the promoter regions of proteins such as KRAS and VGEF, in the presence of C-rich ... which is a signal protein for angiogenesis, induced a conformational change to a hairpin structure that inhibited it from ... Complex Between theBCL2i-Motif and hnRNP LL Is a Molecular Switch for Control of Gene Expression That Can Be Modulated by Small ...

https://en.wikipedia.org/wiki/I-motif_DNA

It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural ... is an NOS inhibitor that is under development as a neuroprotective agent for the treatment of traumatic brain injury.[1] Other ... is involved in regulation of cardiac function and angiogenesis (growth of new blood vessels). NO produced by eNOS has been ...

https://en.wikipedia.org/wiki/Nitric_oxide_synthase

June 2010). "Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of ... and Enhance Angiogenesis In Vitro". Stem Cells and Development. 24 (14): 1635-47. doi:10.1089/scd.2014.0316. PMC 4499790. PMID ... to specialize in cell-cell communications and provide an exclusive approach for the delivery of various therapeutic agents to ... "Fibrin glue mesh fixation combined with mesenchymal stem cells or exosomes modulates the inflammatory reaction in a murine ...

https://en.wikipedia.org/wiki/Exosome_(vesicle)

Both of these steroid work by modulating inflammatory cytokines. Endophthalmitis, or a bacterial infection within the eye ... "Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature". Eye. 27 ( ... preventing them from binding to VEGF receptors on the surface of endothelial cells thereby stopping the abnormal angiogenesis ... "Meta-Analysis of Endophthalmitis After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents". Retina. 31 (4 ...

https://en.wikipedia.org/wiki/Intravitreal_administration

Antineoplastic Agents, Immunological. Antineoplastic Agents. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth ... For this reason and because anti-angiogenic agents are known to be teratogenic, women of child-bearing potential and men must ... Participants receiving erythropoiesis-stimulating agents unless they are on a stable dose for at least 4 weeks prior to consent ... Pregnant women are excluded from this study because bevacizumab is an anti-angiogenic agent with the potential for teratogenic ...

https://clinicaltrials.gov/ct2/show/NCT04404881

Angiogenesis Modulating Agents. Growth Substances. Physiological Effects of Drugs. Growth Inhibitors. Antineoplastic Agents. ...

https://www.clinicaltrials.gov/ct2/show/NCT03823300

Angiogenesis Modulating Agents. *Regenerative Medicine. *Anti-Mullerian Hormone. .single-neutral-profile-picture_svg__cls-1{ ...

https://medicine.yale.edu/obgyn/drs/faculty/

Xanthohumol is a prenylated chalcone naturally found in hop plants, previously reported to be an effective anticancer agent in ... A number of molecularly targeted agents were reported to modulate angiogenesis, growth factor receptors, cell cycle, and ... and biologic agents [28]. Xanthohumol was reported to modulate activity of estrogen synthase and decrease estrogen synthesis in ... Xanthohumol is a prenylated chalcone naturally found in hop plants, previously reported to be an effective anticancer agent in ...

https://www.hindawi.com/journals/ecam/2015/921306/

... a pharmaceutically suitable carrier or diluent and an amount of the inhibitor composition effective to inhibit the angiogenesis ... Methods and kits using a pharmaceutical composition for use in inhibiting ocular angiogenesis or fibrosis are provided herein, ... the composition and/or the other anti-angiogenesis agent modulates expression or activity of a molecule in an angiogenesis ... and an anti-angiogenesis agent or an anti-fibrosis agent, wherein the product is effective for use in anti-angiogenesis or anti ...

https://patents.justia.com/patent/20150320782

Angiogenesis Modulating Agents - Preferred Concept UI. M0443876. Scope note. Agents that modulate the PHYSIOLOGIC ANGIOGENESIS ... Agents that modulate the PHYSIOLOGIC ANGIOGENESIS process. This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety ... general or unspecified; prefer specifics; coordinate with specific agents. Allowable Qualifiers:. AD administration & dosage. ... This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety of other chemicals and pharmaceutical agents. ...

https://decs.bvsalud.org/en/ths/resource/?id=38326

In this review, we provide an overview of extracellular vesicles (EVs), with a focus on their utility as therapeutic agents for ... In this review, we provide an overview of extracellular vesicles, with a focus on their utility as therapeutic agents for ... CDC-EVs induce cardiomyogenesis and angiogenesis, reduce fibrosis, modulate the immune response, and generally improve cardiac ... Extracellular Vesicles as Therapeutic Agents for Cardiac Fibrosis. Russell G. Rogers, Alessandra Ciullo, Eduardo Marbán* and ...

https://www.frontiersin.org/articles/10.3389/fphys.2020.00479/full

Angiogenesis Modulating Agents (Phase 2) Ascites (Phase 2) Astrocytoma (Phase 2) Barrett Esophagus (Phase 2) ... of the patients studied in RCC in order to manage the significant toxicities of this agent. NCATS ...

https://www.cdek.liu.edu/api/64654/

Angiogenesis Modulating Agents. Agentes Moduladores de la Angiogénesis. Anti-Retrovirais. Anti-Retroviral Agents. Agentes ... Angiogenesis Inducing Agents. Agentes Inductores de Angiogénesis. Agentes Moduladores da Angiogênese. ...

https://decs.bvs.br/P/new_2004.htm

Agents modulating oxidative stress, inflammation, and angiogenesis are quite promising for alleviation of diabetic skin ulcers ... Nevertheless, SCE is proposed as an anti-melanogenic and antioxidant agent, which could be further developed into cosmetic skin ... A novel alginate from Sargassum seaweed promotes diabetic wound healing by regulating oxidative stress and angiogenesis. ... Together, these results suggest that Gs have the ability to inhibit osteoclastogenesis by modulating IRF-8 signaling. ...

https://pesquisa.bvsalud.org/portal/?lang=pt&q=mh:Sargassum/metabolismo

Pharmacological Actions : Angiogenesis Modulating Agents. Additional Keywords : Polysaccharides. [+] Mulberry fruit cultivar ...

https://greenmedinfo.com/substance/indian-mulberry

Humans , Angiogenesis Modulating Agents , Endothelial Cells/physiology , Neovascularization, Physiologic/physiology , Exercise ... Animals , Chick Embryo , Female , Rats , Angiogenesis Inducing Agents/pharmacology , Calendula/chemistry , Flowers/chemistry , ... The final phase is characterized by vascular maturation of the physiological angiogenesis. In conclusion, coronary angiogenesis ... Angiogenesis Inducing Agents/pharmacology , Human Umbilical Vein Endothelial Cells/drug effects , Proteoglycans , Reference ...

https://pesquisa.bvsalud.org/gim/?lang=en&q=mh:%22Neovascularization,%20Physiologic/physiology%22

Cold triggers VEGF dependent but hypoxia independent angiogenesis in adipose tissues and anti-VEGF agents modulate adipose ... Cold triggers VEGF dependent but hypoxia independent angiogenesis in adipose tissues and anti-VEGF agents modulate adipose ... These findings demonstrate that VEGFR2 and VEGFR1 mediate polarized activities in modulating adipose angiogenesis and ... Taken together, our findings have conceptual implications in applying angiogenesis modulators for the treatment of obesity and ...

http://biogps.org/dataset/E-GEOD-13432/transcription-profiling-of-mouse-adipose-tissue-ex/

angiogenesis modulating agent metabolite angiogenesis modulating agent metabolite Show first 5 Terms ...

http://zfin.org/action/ontology/term-detail/CHEBI:2873

https://decs2011.bvsalud.org/P/new_2004.htm

Angiogenesis Inducing Agents. Agentes Indutores da Angiogênese. Agentes Moduladores de la Angiogénesis. Angiogenesis Modulating ... Emulsifying Agents. Emulsificantes. Agentes Inductores de Angiogénesis. ... Anti-Retroviral Agents. Anti-Retrovirais. Agentes Emulsionantes. ...

https://decs2018.bvsalud.org/E/new_2004.htm

https://decs2008.bvsalud.org/E/new_2004.htm

https://decs2012.bvsalud.org/E/new_2004.htm

https://decs2010.bvsalud.org/E/new_2004.htm

Angiogenesis Inducing Agents. Agentes Indutores da Angiogênese. Agentes Inductores de Angiogénesis. Angiogenesis Modulating ... Anti-Retroviral Agents. Anti-Retrovirais. Agentes Antirretrovirales. Emulsifying Agents. Emulsificantes. Agentes Emulsionantes ... Natriuretic Agents. Natriuréticos. Agentes Natriuréticos. Physiological Effects of Drugs. Efeitos Fisiológicos de Drogas. ... D18 - Cardiovascular Agents. Endothelium-Dependent Relaxing Factors. Fatores Relaxantes Dependentes do Endotélio. Factores ...

https://decs2019.bvsalud.org/I/new_2004.htm

https://decs2016.bvsalud.org/P/new_2004.htm

https://decs2009.bvsalud.org/I/new_2004.htm

https://decs2015.bvsalud.org/I/new_2004.htm

https://decs2013.bvsalud.org/E/new_2004.htm

https://decs2020.bvsalud.org/I/new_2004.htm

https://decs2014.bvsalud.org/E/new_2004.htm

https://decs2017.bvsalud.org/I/new_2004.htm

https://decs2007.bvsalud.org/I/new_2004.htm

NPs are versatile agents that can target major TME components to modulate the immunosuppressive environment. For example, ... They used gold NPs as a carrier for delivering recombinant endostatin, which inhibits angiogenesis and lymphatic metastasis by ... Those cascades are modulated by CAFs in tumors, promote the exclusion of T cells, and prevent contact between tumor and T cells ... Nanoparticle strategies for modulating the tumor extracellular matrix. Metastasis involves the spread and development of a ...

https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-022-01476-9

Angiogenesis Modulating Agents. *Growth Inhibitors. *Micronutrients. *Plant Growth Regulators. Below are MeSH descriptors whose ...

https://profiles.jefferson.edu/display/11653

The dual mTORC1/mTORC2 inhibitors, OSI-027, and OXA-01 have already been shown to significantly decrease angiogenesis and regrowth in comparison to rapamycin (mTORC1 inhibitor) by itself. (colinsbraincancer.com)
Findings highlight single agent X4P-001-IO has the ability to help restore immunity within the TME and has the potential to enhance the anti-tumor activity of agents such as checkpoint inhibitors. (x4pharma.com)
8 ] Therapies targeting angiogenesis were introduced in early 2003 with trials of inhibitors of VEGF-R2 and its ligand, VEGF, as well as the downstream mediator, mTOR. (jcancer.org)
These findings identify DNA damage agents and pharmacologic inhibitors of RhoJ/PAK1 as novel synergistic agents that can be used to treat melanomas that are resistant to conventional chemotherapies. (aacrjournals.org)
Cancer Biology division strives on the interdisciplinary research that translates the new findings into developing of angiogenesis inhibitors, early detection/therapeutics using cancer stem cells and gene editing, omics technology, radio-sensitizing agents, biosensors and genetic screening including epigenetics of cell cycle regulation and xenograft models for personalized medicine. (yenepoya.res.in)
Histone deacetylase inhibitors (HDACis) have emerged as a promising new class of multifunctional anticancer agents. (medscape.com)
Angiogenesis, which is the process by which new blood vessels develop from preexisting vessels, is governed by a very complex network of opposing signals that, under normal physiological conditions, are elicited by various highly regulated angiogenesis stimulators and inhibitors [ 1 ]. (hindawi.com)
During tumor-associated angiogenesis, the balance of angiogenesis stimulators and inhibitors is tipped in favor of angiogenesis by hypoxia-inducible factor-1 gene expression [ 2 ]. (hindawi.com)

The overexpression of Axl has been shown to be associated with epithelial-to-mesenchyaml transition (EMT), anticancer drug resistance and angiogenesis ( 16 - 18 ), whereas Axl inhibition decreased cancer cell growth and migration and increased sensitivity to anticancer drugs ( 19 ). (spandidos-publications.com)
Manipulation of c-MPL splicing in myeloid leukemia, evaluation of incidence for BRCA1 mutation in women, revealing the drug action in the tumor microenvironment, adjuvant treatment development for glioma by a combination of gamma radiation and angiogenesis inhibition, immune-modulation in lung cancer. (yenepoya.res.in)
Inhibition of angiogenesis can control tumor metastasis and improve the prognosis [ 3 - 6 ]. (hindawi.com)
Reduces cell proliferation and angiogenesis by inhibition of mTOR pathway. (medscape.com)

This pathway may also regulate angiogenesis by modulating appearance of nitric oxide and angiopoietins. (colinsbraincancer.com)
However, the exact mechanisms by which epoxygenases regulate angiogenesis are still unclear. (uni-frankfurt.de)

Abstract We recently demonstrated that a co-culture system of human umbilical vein endothelial cells (HUVECs) and human dental pulp stem cells (hDPSCs) could enhance angiogenesis ability in vitro. (bvsalud.org)
Hypoxia inducible factor (HIF) plays a pivotal role in the adaptation to ischemic conditions, and its activity is modulated by an oxygen-dependent hydroxylation of proline residues by prolyl hydroxylases (PHD). We discovered a unique compound TM6008, which inhibited PHD and stabilized HIF activity in vitro. (neurology-jp.org)
To clarify whether EphB4 is a critical determinant of CYP2C9-induced angiogenesis, endothelial cell sprouting was assessed using a collagen gel-based in vitro angiogenesis assay. (uni-frankfurt.de)
Moreover, it has been proven to be effective as anticancer agent in different tumor models both in vitro and in vivo , potentiating the cytotoxic effect of several chemotherapy compounds such as Lapatinib, Gemcitabine, Paclitaxel, Sorafenib and Irinotecan. (medsci.org)
The ability of overexpressed miRNAs within microvesicles to modulate a critical physiological process will be assessed using an in vitro model of angiogenesis. (ukri.org)
Endothelial cell (EC) proliferation assays using human retinal microvascular endothelial cells (HRMECs) or isolated primary retinal ECs are widely used in vitro models to study retinal angiogenesis. (harvard.edu)
In this study, we investigated the effect of N-desulfated heparin on bFGF expression, angiogenesis, and tumor metastasis in vitro and in vivo. (hindawi.com)

The protection was associated with amelioration of apoptosis but independent of enhanced angiogenesis. (neurology-jp.org)
NO has been suggested to modulate different cancer-related events including angiogenesis, apoptosis, cell cycle, invasion, and metastasis. (thetruthaboutcancer.com)
Vitamin D is safe for use in the pet and is known for its ability to aid in cell differentiation and apoptosis (ridding itself of dead cells), and also inhibits angiogenesis (blood supply to the tumor). (healyourlife.com)

Since the TME modulates drug function and penetration, it can aggravate drug resistance by protecting pro-proliferation factors in the TME and tumor mass [ 2 ]. (biomedcentral.com)
Many real estate agents have been made that may inhibit PI3K and/or mTOR signaling in tumor cells, and these medications have results on angiogenesis aswell as on tumor cell proliferation and success. (colinsbraincancer.com)
They have a number of roles in the regulation of vascular tone and homeostasis by activating different signal transduction pathways and have recently been reported to be involved in proliferation and angiogenesis. (uni-frankfurt.de)
According to research published in Clinics in Dermatology , they can be used in the dermatology and skin care industries to improve skin issues, such as inflammation, pigmentation, cell proliferation and migration, and changes in angiogenesis (making new blood vessels). (draxe.com)
mTOR, a serine/threonine kinase, is thought to play a central role in regulating cell growth, proliferation, cellular metabolism and angiogenesis [ 7 ]. (jcancer.org)
Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. (idrblab.net)

In 2005 and 2006, teams of researchers learned that ginger extract has the ability to modulate radiation-induced Conditioned Taste Aversion (CTA) (Sharma et al. (aphios.com)
Several agents have demonstrated an ability to modulate the tumour cell microenvironment, including immunotherapies such as sipuleucel T and ipilimumab. (touchoncology.com)

Angiogenesis is the physiological process involving the growth of new blood vessels from pre-existing vessels. (aphios.com)
We have chosen to concentrate on a critical physiological process called angiogenesis, whereby new blood vessels are formed from pre-existing vessels. (ukri.org)
Angiogenesis is essential for tumor growth beyond a few millimeters in diameter because of the tumor's requirement for a network of blood vessels to deliver oxygen and nutrients and to remove waste products of metabolism. (hindawi.com)
Angiogenesis, the development of new blood vessels from the preexisting ones, is essential for the growth and development of body tissues that can be affected by diabetes [3] , [4] . (eg.net)

Taken together, our findings have conceptual implications in applying angiogenesis modulators for the treatment of obesity and metabolic disorders. (biogps.org)

Xanthohumol is a prenylated chalcone naturally found in hop plants, previously reported to be an effective anticancer agent in various cancer cell lines. (hindawi.com)
The aim of this review is to put some light on the potential of this nutritional mixture as an anticancer agent and complement for the standard chemotherapy routine. (medsci.org)

They shape the TME by building large portions of the (ECM) and enhance tumorigenesis and angiogenesis through cytokines, growth factors and matrix metalloproteinases, which induce TME remodeling [ 2 , 3 ]. (biomedcentral.com)

Thus, tumor metabolism, gene expression, or epigenetic modifications are modulated, cell growth is impaired and angiogenesis and metastasis are inhibited. (drcolinholloway.com)
The present study was performed to investigate the effect of N-desulfated heparin on basic fibroblast growth factor (bFGF) expression, tumor angiogenesis and metastasis of gastric carcinoma. (hindawi.com)
N-desulfated heparin can inhibit the metastasis of gastric cancer through inhibiting tumor bFGF expression and tumor angiogenesis with no obvious anticoagulant activity. (hindawi.com)
Recent studies have showed that angiogenesis plays a crucial role in tumor growth and metastasis. (hindawi.com)
Anti-VEGF therapy is effective in inhibiting angiogenesis and metastasis of tumor [ 9 , 10 ]. (hindawi.com)

The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. (biogps.org)
Intriguingly, VEGFR2 blockage abolished the cold-induced angiogenesis, significantly impaired nonshivering thermogenesis capacity, and markedly reduced adipose metabolism. (biogps.org)
These findings demonstrate that VEGFR2 and VEGFR1 mediate polarized activities in modulating adipose angiogenesis and metabolism. (biogps.org)

In addition, xanthohumol modulated the alkaline phosphatase isoenzymes that were expressed in malignant tissues [ 8 ] and was able to inhibit production of inflammatory factors, DNA synthesis and angiogenesis in MCF-7 cells, and breast cancer xenografts in mice [ 9 ]. (hindawi.com)
Methods and kits using a pharmaceutical composition for use in inhibiting ocular angiogenesis or fibrosis are provided herein, such that composition includes a pharmaceutically suitable carrier or diluent and an amount of the inhibitor composition effective to inhibit the angiogenesis or the fibrosis by inhibiting expression and/or activity of a galectin protein or a portion thereof. (justia.com)
Together, these results suggest that Gs have the ability to inhibit osteoclastogenesis by modulating IRF-8 signaling. (bvsalud.org)
For instance, in 2006 a two-part series on "Natural Health Products That Inhibit Angiogenesis" (Sagar et al. (aphios.com)

In this review, we summarize EV biology, cellular and molecular players in myocardial fibrosis, the utility of EVs as therapeutic agents, and conclude with the promise of engineered EVs as next-generation therapeutic candidates. (frontiersin.org)
Conclusion: The induction of diabetes decreased angiogenesis in the myocardium, whereas our treatment using long-term voluntary exercise and garlic improved myocardial angiogenesis. (bvsalud.org)
Objectives: Cell sheet implantation induces angiogenesis for chronic myocardial infarction (MI), though insufficient capillary maturation and paucity of arteriogenesis may limit its therapeutic effects. (alliedacademies.org)

For example, angiogenesis and rapid tumor growth result in hypoxia and immunosuppression by activating T regs and MDSCs, which secrete vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-β [ 2 ]. (biomedcentral.com)
We wanted to investigate the role of epidermal growth factor-like domain 7 (EGFL7) in VEGF-driven angiogenesis using an ex vivo Matrigel-embedded mouse eye cup assay and siRNA mediated knockdown of EGFL7 by siRNA. (harvard.edu)
Thus, in conclusion, EGFL7 is required for VEGF upregulation of the Akt/Erk (1/2) pathway during angiogenesis, and may represent a new therapeutic target in diseases of pathological neovascularization. (harvard.edu)
Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) are the main factors promoting angiogenesis [ 7 , 8 ]. (hindawi.com)
Chemically modified heparin shows a significantly reduced anticoagulant activity and enhanced ability to interact with FGF, VEGF, and hepatocyte growth factor, which are known to stimulate angiogenesis [ 13 ]. (hindawi.com)
In fact, diabetes reduces the rate of angiogenesis by alteration in the expression angiogenic genes such as vascular endothelial growth factor (VEGF) [6] . (eg.net)

2001). Open up in another window Shape 1 PI3K/AKT/mTOR pathway in angiogenesis. (colinsbraincancer.com)

These results may provide the molecular MOA of CTO's observed clinical benefit in a broad spectrum of tumors with different genomic types and a tool to design customized combination therapies of CTO with other agents Arm C of the phase I/II study expected to initiate in December 2013 will include pharmacodynamic marker analysis. (tacticaltherapeutics.com)
Aside from its anticoagulant action, heparin binds to various growth factors, cytokines, and extracellular proteins and consequently is able to affect migration of cancer cells and angiogenesis in tumors. (hindawi.com)
Reports of chemotherapeutic agent use in the second and third trimester for other ovarian tumors exist, but caution should be taken because little is known about the long-term effects on the developing fetus. (medscape.com)

A number of molecularly targeted agents were reported to modulate angiogenesis, growth factor receptors, cell cycle, and inflammation in cervical cancer signaling pathways. (hindawi.com)
In the last 2 years, new molecules directed against integrins and integrin receptors have been developed and investigated in clinical trials, showing that anti-α4β7 integrin agents can be effective and safe for the induction and maintenance of remission in active CD and UC. (medscape.com)
They act through cell surface receptors to modulate communication between cells. (konsyse.com)
Current successful therapies include hormone-based agents that directly target these receptors. (medscape.com)

IMSEAR at SEARO: Dietary grapes (Vitis vinifera) feeding attenuates ethanol-induced oxidative stress in blood and modulates immune functions in mice. (who.int)
Results revealed that feeding of both grape skin and flesh (2.5 g/kg body wt/day) effectively attenuated the oxidative stress and alterations in immune function and angiogenesis induced by chronic ethanol consumption (1.6 g/kg body wt/day for 12 weeks) in mice. (who.int)

Angiogenesis-associated disorders in the eye, such as choroidal neovascularization, result in hemorrhaging and fibrosis in the eye, and visual loss. (justia.com)
Choroidal neovascularization is an angiogenesis-associated disorder that causes hemorrhaging, fibrosis, and visual loss (Kumar-Singh et al. (justia.com)

Therefore, the initial aim of the present study was to characterize the relevance of major signalling molecules that are involved in angiogenesis and to investigate possible signalling pathways involved. (uni-frankfurt.de)

9 , 10 ] Since that time, seven agents targeting the angiogenesis pathway have been FDA approved for use in patients with advanced kidney cancer. (jcancer.org)

In addition, through MAPK/Erk activation, ADM signaling modulates additional downstream pathways which enhance the growth and survival of endothelial cells [ 11 ]. (biomedcentral.com)

This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety of other chemicals and pharmaceutical agents. (bvsalud.org)
Therefore, KS and KSHV are recognized as an excellent model to study angiogenesis and to discover new angiogenic mechanisms, including coding and non-coding RNAs. (biomedcentral.com)

MicroRNAs (miRNAs) have emerged as master regulators of angiogenesis and other cancer-related events. (biomedcentral.com)
Discovering new angiogenesis-regulating microRNAs (angiomiRs) will eventually help in developing new therapeutic strategies for tumor angiogenesis and cardiovascular diseases. (biomedcentral.com)
The main expected outcome of this project is knowledge of whether gene expression can be modulated by microRNAs carried by microvesicles and if this is an important mechanism. (ukri.org)

NPs are versatile agents that can target major TME components to modulate the immunosuppressive environment. (biomedcentral.com)

Objective: The present study sought to explore the effect of garlic and voluntary exercise, alone or together, on miR-126 and miR-210 expressions and cardiac angiogenesis in rats with type 1 diabetes. (bvsalud.org)

Since the antioxidants play a crucial role in the modification of the angiogenesis [11] , it seems that the P. crispum plant can protect the angiogenesis in diabetic-induced stress. (eg.net)

Moreover, Dicer effects in vivo angiogenesis, a process which is unaffected by Drosha. (uni-frankfurt.de)
The ex vivo choroid-sprouting assay, including primary retinal pigment epithelium (RPE) and choroid, without retina was used to investigate whether FFAR4 affects choroidal angiogenesis. (harvard.edu)

arboxyamidotriazole-Orotate Inhibits the Growth of Imatinib-Resistant Chronic Myeloid Leukaemia Cells and Modulates Exosomes-Stimulated Angiogenesis. (tacticaltherapeutics.com)
The anti-cancer effects of curcumin include inhibiting the carcinogenesis, inhibiting angiogenesis, and inhibiting tumour growth. (lolitaink.shop)
The omentum, as a source of angiogenesis factors, has been used clinically to promote revascularization and healing of ischemic tissues by modulating growth of vasculature. (alliedacademies.org)
Inositol hexaphosphate is very effective for killing cancer cells, inhibits cancer growth, and modulates the immune system. (healyourlife.com)
They help modulate the immune system and slow cancer growth rate. (healyourlife.com)
Collectively, these data support the hypothesis that monocytes/macrophages exposed to filarial ES products may modulate lymphatic function through the secretion of soluble factors that stimulate the vessel growth associated with the pathogenesis of filarial disease. (cdc.gov)

In this review, we provide an overview of extracellular vesicles (EVs), with a focus on their utility as therapeutic agents for cardiac regeneration. (frontiersin.org)
Cardiac angiogenesis disruption occurs in diabetes. (eg.net)
The hydroalcoholic extract of P. crispum did not affect cardiac angiogenesis in normal and diabetic patients, which probably is due to the insufficient amounts of active ingredients, especially flavonoids available in P. crispum . (eg.net)

Angiogenesis 2020;23(3):385-394. (harvard.edu)

New treatment principles are emerging in current practice, such as metabolic modulation, therapeutic angiogenesis, and novel interventional techniques (coronary in-flow redistribution and approaches to chronic total occlusion). (nature.com)

how to add viewport in revit A unique way in which curcumin combats lung cancer is by modulating microRNA inside cancer cells.²⁸ ²⁹ ³⁰ These short stretches of genetic material regulate how the main …Non-small cell lung cancer (NSCLC) has the highest proportion of lung malignancies at 80%, and the absence of practical early-detection tools is one of the main reasons for its poor prognosis. (lolitaink.shop)
More importantly, as immunomodulating agents, they are important in cell signaling. (konsyse.com)
They also modulate the balance between humoral and cell-mediated immune responses. (konsyse.com)
Angiogenesis relies on cell-cell communication and can be readily studied in the laboratory setting. (ukri.org)

4,5 Current approved therapeutic options for advanced and CRPC include chemotherapy (docetaxel, cabazitaxel), immunotherapy (sipuleucel-T), bone targeted agents (denosumab, radium-223 [RA-223]) and new-generation endocrine therapies (abiraterone acetate, enzalatumide). (touchoncology.com)

Modulates the immune system, reduces some side effects of certain chemotherapy agents, and is a powerful anti-oxidant. (healyourlife.com)

Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers. (drcolinholloway.com)

CXCR4 is a chemokine receptor that modulates immune function and angiogenesis through the trafficking of key immune cells such as T- cells, dendritic cells, and myeloid derived suppressor cells. (x4pharma.com)
These include angiogenesis, breakdown of basement membrane walls, recruitment of immune-suppressive T regulatory cells, and suppression of antitumor immune responses. (aacr.org)
The company shares a broad strategic alliance with MD Anderson Cancer Center that is enabling them to discover antibodies from Elite Responders to cancer immunotherapy that target and modulate immune cells in the tumor microenvironment (TME). (scientificinquirer.com)

Several interventional agents of plant origin, in particular fruits and vegetables have been used to counteract these alterations induced by ethanol. (who.int)

Cytokines are immunomodulating agents responsible for regulating the immune response. (konsyse.com)

Although advances in basic science regarding the new potential therapeutic targets have been done, the anti-TNF-α agents are the only biological agents currently available in Europe for IBD, which may indirectly block mechanisms of leukocyte recruitment, through inhibiting angiogenesis. (medscape.com)

This study will provide information on understanding viral-host protein interactions affecting the modulation of angiogenesis and can lead to therapeutic targets for KSHV infection. (csu-icm.org)

Pathological choroidal angiogenesis, a salient feature of age-related macular degeneration, leads to vision impairment and blindness. (harvard.edu)

In this mouse model, the FFAR4 agonist suppressed CNV, suggesting FFAR4 to be a new molecular target to reduce pathological angiogenesis in CNV. (harvard.edu)

Kaposi's sarcoma (KS), which is induced by the etiological infectious agent KS-associated herpesvirus (KSHV), is a peculiar neoplasm that expresses both blood and lymphatic endothelial markers and possesses extensive neovasculature. (biomedcentral.com)
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus and the causative agent for Kaposi's sarcoma (KS). (csu-icm.org)
I hypothesize that KSHV vGPCR interacts with EMC10 and MGAT5 and that these interactions modulate angiogenesis. (csu-icm.org)

The effects of curcumin were compared with the lung tumor promoter, butylated hydroxytoluene (BHT), and the lung cancer chemopreventive agent, sulindac. (lolitaink.shop)

Anti-Inflammatory and Analgesic Potency of Carboxyamidotriazole, a Tumorostatic Agent. (tacticaltherapeutics.com)
The study concluded that Z. officinale , gingerol and shogaol show potential as anti-inflammatory agents to protect skin against UV irradiation damage. (aphios.com)

Currently there very few effective treatments for angiogenesis-associated disorders of the eye such as wet AMD and dry AMD. (justia.com)
Even though new treatments are now being implemented, administration of these chemotherapeutic agents remains as the first line option in many tumor types. (medsci.org)

Amongst these are the chemotherapeutic agents currently used as advanced and metastatic cervical cancer treatment options, such as cisplatin, paclitaxel, topotecan, cetuximab, and bevacizumab. (hindawi.com)

Anatomy29

Organisms13

Diseases33

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes35

Disciplines and Occupations1

Information Science1

COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. (1/26)

Current methods for assaying angiogenesis in vitro and in vivo. (2/26)

Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle. (3/26)

Bartonella adhesin a mediates a proangiogenic host cell response. (4/26)

Vascular endothelial growth factor and angiogenesis. (5/26)

The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. (6/26)

New insights into the biology of preeclampsia. (7/26)

A cell-based model exhibiting branching and anastomosis during tumor-induced angiogenesis. (8/26)

Neovascularization, Pathologic

Angiogenesis Inhibitors

Neovascularization, Physiologic

Angiogenesis Inducing Agents

Vascular Endothelial Growth Factor A

Endothelial Cells

Vascular Endothelial Growth Factors

Endothelial Growth Factors

Endothelium, Vascular

Vascular Endothelial Growth Factor Receptor-2

Lymphokines

Angiogenic Proteins

Angiogenesis Modulating Agents

Human Umbilical Vein Endothelial Cells

Cell Movement

Chorioallantoic Membrane

Capillaries

Fibroblast Growth Factor 2

Mice, Nude

Blood Vessels

Allantois

Antigens, CD31

Cell Proliferation

Receptors, Vascular Endothelial Growth Factor

Corneal Neovascularization

Angiopoietin-2

Angiopoietin-1

Cells, Cultured

Ischemia

Thrombospondin 1

Umbilical Veins

Receptor, TIE-2

Signal Transduction

Cell Line, Tumor

Chorion

Hindlimb

Microvessels

Mice, Inbred C57BL

Hypoxia-Inducible Factor 1, alpha Subunit

Neoplasms

Vascular Endothelial Growth Factor Receptor-1

Immunohistochemistry

Endostatins

Microcirculation

Integrin alphaVbeta3

Neoplasm Transplantation

Retinal Neovascularization

Intercellular Signaling Peptides and Proteins

Laminin

Cell Division

Carcinoma, Lewis Lung

Drug Combinations

Disease Models, Animal

Wound Healing

Xenograft Model Antitumor Assays

RNA, Messenger

Chick Embryo

Cyclohexanes

Angiostatins

Pericytes

Collagen

Transplantation, Heterologous

Proteoglycans

Receptors, Growth Factor

Apoptosis

Reverse Transcriptase Polymerase Chain Reaction

Cell Hypoxia

Retinal Vessels

Blotting, Western

Gene Expression Regulation, Neoplastic

Mice, Knockout

Mice, Inbred BALB C

Lymphangiogenesis

Angiopoietins

Neoplasms, Experimental

Up-Regulation

Receptor Protein-Tyrosine Kinases

Mice, SCID

Angiostatic Proteins

Cornea