Angina, Unstable: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.Sick Building Syndrome: A group of symptoms that are two- to three-fold more common in those who work in large, energy-efficient buildings, associated with an increased frequency of headaches, lethargy, and dry skin. Clinical manifestations include hypersensitivity pneumonitis (ALVEOLITIS, EXTRINSIC ALLERGIC); allergic rhinitis (RHINITIS, ALLERGIC, PERENNIAL); ASTHMA; infections, skin eruptions, and mucous membrane irritation syndromes. Current usage tends to be less restrictive with regard to the type of building and delineation of complaints. (From Segen, Dictionary of Modern Medicine, 1992)Acute Coronary Syndrome: An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Percutaneous Coronary Intervention: A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.Coronary Vessels: The veins and arteries of the HEART.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Superstitions: A belief or practice which lacks adequate basis for proof; an embodiment of fear of the unknown, magic, and ignorance.Heart: The hollow, muscular organ that maintains the circulation of the blood.Chest Pain: Pressure, burning, or numbness in the chest.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Angina Pectoris, Variant: A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Passive Cutaneous Anaphylaxis: An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Angina, Stable: Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.Food Hypersensitivity: Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Legislation, Food: Laws and regulations concerned with industrial processing and marketing of foods.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Job Application: Process of applying for employment. It includes written application for employment or personal appearance.Library Services: Services offered to the library user. They include reference and circulation.Libraries, MedicalStents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.Drug-Eluting Stents: Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.Coronary Restenosis: Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.Anticoagulants: Agents that prevent clotting.Saphenous Vein: The vein which drains the foot and leg.Actuarial Analysis: The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.Veins: The vessels carrying blood away from the capillary beds.Vascular Patency: The degree to which BLOOD VESSELS are not blocked or obstructed.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Leg: The inferior part of the lower extremity between the KNEE and the ANKLE.Graft Occlusion, Vascular: Obstruction of flow in biological or prosthetic vascular grafts.Myocardial Revascularization: The restoration of blood supply to the myocardium. (From Dorland, 28th ed)Acetanilides: Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.Secondary Care Centers: A healthcare facility equipped to provide all but the most specialized forms of care, surgery, and diagnostic techniques.

Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. (1/1246)

BACKGROUND: In a group of patients admitted for unstable angina, we investigated whether C-reactive protein (CRP) plasma levels remain elevated at discharge and whether persistent elevation is associated with recurrence of instability. METHODS AND RESULTS: We measured plasma levels of CRP, serum amyloid A protein (SAA), fibrinogen, total cholesterol, and Helicobacter pylori and Chlamydia pneumoniae antibody titers in 53 patients admitted to our coronary care unit for Braunwald class IIIB unstable angina. Blood samples were taken on admission, at discharge, and after 3 months. Patients were followed for 1 year. At discharge, CRP was elevated (>3 mg/L) in 49% of patients; of these, 42% had elevated levels on admission and at 3 months. Only 15% of patients with discharge levels of CRP <3 mg/L but 69% of those with elevated CRP (P<0.001) were readmitted because of recurrence of instability or new myocardial infarction. New phases of instability occurred in 13% of patients in the lower tertile of CRP (/=8.7 mg/L, P<0.001). The prognostic value of SAA was similar to that of CRP; that of fibrinogen was not significant. Chlamydia pneumoniae but not Helicobacter pylori antibody titers significantly correlated with CRP plasma levels. CONCLUSIONS: In unstable angina, CRP may remain elevated for at >/=3 months after the waning of symptoms and is associated with recurrent instability. Elevation of acute-phase reactants in unstable angina could represent a hallmark of subclinical persistent instability or of susceptibility to recurrent instability and, at least in some patients, could be related to chronic Chlamydia pneumoniae infection.  (+info)

A role for changes in platelet production in the cause of acute coronary syndromes. (2/1246)

Platelets are heterogeneous with respect to their size, density, and reactivity. Large platelets are more active hemostatically, and platelet volume has been found to be increased both in patients with unstable angina and with myocardial infarction. Furthermore, platelet volume is a predictor of a further ischemic event and death when measured after myocardial infarction. Platelets which are anucleate cells with no DNA are derived from their precursor, the megakaryocyte. Therefore, it is suggested that changes in platelet size are determined at thrombopoiesis in the megakaryocyte and that those changes might precede acute cardiac events. Understanding of the signaling system that controls platelet production may also further elucidate the cascade of events leading to acute vascular occlusion in some patients.  (+info)

Cardioprotection by opening of the K(ATP) channel in unstable angina. Is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil. CESAR 2 investigation. Clinical European studies in angina and revascularization. (3/1246)

AIMS: To assess the anti-ischaemic and anti-arrhythmic effects and overall safety of nicorandil, an ATP sensitive potassium (K+) channel opener, with 'cardioprotective' effects, in patients with unstable angina. METHODS: In a multicentre, randomized, double-blind, parallel-group, placebo-controlled study, oral nicorandil 20 mg twice daily or a matching placebo was administered for a minimum of 48 h to patients admitted with unstable angina. Treatment was standardized to include, where tolerated, oral aspirin, a beta-blocker and diltiazem. Continuous Holter ECG monitoring was performed for 48 h to assess the frequency and duration of transient myocardial ischaemia and any tachyarrhythmia, as the predefined end-points of the study. A pain chart recorded the incidence and severity of chest pain throughout the study period. Patients with myocardial infarction identified retrospectively from troponin-T analysis were excluded. RESULTS: Two hundred and forty-five patients were recruited into the study. Forty-three patients were excluded with an index diagnosis of myocardial infarction, two were not randomized and 12 had unsatisfactory tape data. In the remaining 188 patients, six out of 89 patients (6.7%) on nicorandil experienced an arrhythmia, compared with 17 out of 99 patients (17.2%) on placebo (P=0.04). Three nicorandil patients experienced three runs of non-sustained ventricular tachycardia compared to 31 runs in 10 patients on placebo (P=0.087 patients; P<0.0001 runs). Three nicorandil patients had four runs of supraventricular tachycardia, compared to 15 runs in nine patients on placebo (P=0.14 patients; P=0.017 runs). Eleven (12.4%) patients on nicorandil had 37 episodes of transient myocardial ischaemia (mostly silent) compared with 74 episodes in 21 (21.2%) patients on placebo (P=0.12 patients; P=0.0028 episodes). In the overall safety analysis, which included all patients who received at least one dose of study medication, there were no significant differences in the rates of myocardial infarction or death between the nicorandil or placebo-treated groups. CONCLUSIONS: Nicorandil, added to aggressive anti-anginal treatment for unstable angina, reduces transient myocardial ischaemia, non-sustained ventricular, and supraventricular arrhythmia compared to placebo. The anti-arrhythmic activity with nicorandil is probably a secondary effect resulting from its anti-ischaemic action and we suggest that this may be related to its effect on the ATP sensitive potassium channel causing pharmacological preconditioning.  (+info)

Platelet activation in patients after an acute coronary syndrome: results from the TIMI-12 trial. Thrombolysis in Myocardial Infarction. (4/1246)

This study was designed to determine the magnitude and time course of platelet activation during therapy of acute coronary syndromes with an oral platelet antagonist. BACKGROUND: Platelet activation and aggregation are central to the pathogenesis of the acute coronary syndromes (ACS). However, few data are available on levels of platelet activation over time in patients with ACS, especially in the setting of chronic glycoprotein (GP) IIb/IIIa inhibition. METHODS: The Thrombolysis in Myocardial Infarction (TIMI) 12 trial was a phase II, double-blind trial evaluating the effects of sibrafiban, an oral, selective antagonist of the platelet glycoprotein IIb/IIIa receptor in patients stabilized after an ACS. A subset of 90 of the 329 patients in the study had measurement of platelet activation as assessed by the expression of platelet associated P-Selectin on days 0, 7 and 28. Platelet activation was measured in blood samples that were fixed either immediately (spontaneous activation) or after 5 minute incubation with 0, 1 microM or 5 microM ADP in order to assess platelet responsiveness to very low or moderate stimulation. RESULTS: At baseline there was a significant elevation of spontaneous platelet activation as compared to samples obtained from normal donors or from patients who did not have acute coronary syndromes (ACS patients 27.6+/-18.7%, Normal controls 8.5+/-4.4%, Patient controls 10.9+/-7.1%, p < 0.005 for both). In addition, there was a significant decrease in the levels of platelet activation with time during the 28 days of treatment with sibrafiban. Nevertheless, even on day 28, the TIMI-12 patients continued to show elevated platelet activation in comparison to the control groups (p < 0.05 for both). CONCLUSIONS: These results suggest that platelets remain activated long after clinical stabilization post ACS. Although platelet activation decreased after one month of oral GPIIb/IIIa inhibition, levels remained higher than normal, suggesting the need for long-term antiplatelet therapy following ACS.  (+info)

Does coronary artery morphology predict favorable results of intracoronary thrombolysis in patients with unstable angina pectoris? (5/1246)

The efficacy of intracoronary thrombolysis (ICT) for unstable angina pectoris (UAP) has been limited, despite the similar pathogenesis between UAP and acute myocardial infarction. To ascertain the subset of UAP suitable for ICT, the clinical responses to ICT were assessed in patients with UAP. Eighty-2 patients with medically refractory angina were divided into 2 groups according to the coronary artery morphology of the culprit lesion before ICT: (1) lesions with acute cut off and/or filling defects (AC) and (2) lesions with a tapered shape (TA). The TIMI flow grade was determined from coronary angiograms before and immediately after ICT. The diameter stenosis (%DS) and minimal lumen diameter (MLD) of the culprit lesion were determined using quantitative coronary angiographic analysis before and immediately after ICT. In addition, inhospital cardiac event rates including urgent/emergency coronary angioplasty or bypass surgery, nonfatal myocardial infarction or cardiac death were compared between the 2 groups. Multivariate logistic regression analysis was performed using 13 clinical factors contributing to successful ICT. The results showed that all 3 coronary angiographic parameters (TIMI flow, %DS, and MLD) significantly improved in the AC group (p<0.01, p<0.01 and p<0.05, respectively), whereas none of these parameters improved in the TA group. The inhospital cardiac event rate after ICT was significantly higher in the TA group (76%) than in the AC group (48%; p=0.016). Odds ratio predicting successful ICT was 7.09 (p<0.01) for the AC lesion, and 2.54 (p<0.01) for new angina. In conclusion the AC lesions are more commonly associated with coronary thrombosis that responds to ICT than are the TA lesions. Thus, the coronary angiographic morphology may be an important predictor for a successful ICT in patients with medically refractory UAP.  (+info)

Coronary artery stenting in unstable angina pectoris: a comparison with stable angina pectoris. (6/1246)

OBJECTIVE: To compare early complication rates in unselected cases of coronary artery stenting in patients with stable v unstable angina. SETTING: Tertiary referral centre. PATIENTS: 390 patients with stable angina pectoris (SAP) and 306 with unstable angina (UAP). Patients treated for acute myocardial infarction (primary angioplasty) or cardiogenic shock were excluded. INTERVENTIONS: 268 coronary stents were attempted in 211 patients (30.3%). Stents used included AVE (63%), Freedom (14%), NIR (7%), Palmaz-Schatz (5%), JO (5%), and Multilink (4%). Intravascular ultrasound was not used in any of the cases. All stented patients were treated with ticlopidine and aspirin together with periprocedural unfractionated heparin. RESULTS: 123 stents were successfully deployed in 99 SAP patients v 132 stents in 103 UAP patients. Failed deployment occurred with nine stents in SAP patients, v four in UAP patients (NS). Stent thrombosis occurred in four SAP patients and 11 UAP patients. Multivariate analysis showed no relation between stent thrombosis and clinical presentation (SAP v UAP), age, sex, target vessel, stent length, or make of stent. Stent thrombosis was associated with small vessel size (p < 0.001) and bailout stenting (p = 0.01) compared with elective stenting and stenting for suboptimal PTCA, with strong trends toward smaller stent diameter (p = 0.052) and number of stents deployed (p = 0.06). Most stent thromboses occurred in vessels < 3 mm diameter. CONCLUSIONS: Coronary artery stenting in unstable angina is safe in vessels >/= 3 mm diameter, with comparable initial success and stent thrombosis rates to stenting in stable angina.  (+info)

Treatment with the antibiotic roxithromycin in patients with acute non-Q-wave coronary syndromes. The final report of the ROXIS Study. (7/1246)

AIMS: Mounting evidence suggests infection, specifically Chlamydia pneumoniae, plays a role in atherosclerosis. We tested whether antibiotic treatment with the macrolide roxithromycin improves clinical outcome in patients with acute non-Q-wave coronary syndromes. Preliminary reports revealed a reduction in events in the roxithromycin group at 30 days. We now report the long-term follow-up results. METHODS AND RESULTS: Sixty-four per cent of the initial 202 patients with unstable angina who were randomly assigned to receive either roxithromycin or placebo for 30 days completed the active treatment period. At day 30, the primary triple and double end-point rates were 9% and 4% in the placebo group compared to 2% and 0% in the roxithromycin group (unadjusted P = 0.032 and 0.058, respectively). The secondary triple and double end-point rates were again higher in the placebo group at day 90 (12.5% and 6.25% vs 4.37% and 0%, unadjusted P = 0.065 and 0.029, respectively), and at day 180 (14.6% and 7.29% vs 8.69% and 2.17%, unadjusted P = 0.259 and 0.17, respectively). Anti-C, pneumoniae IgG titres were unchanged in both groups while C-reactive protein levels decreased in both strategies, with a more significant decrease in the roxithromycin arm (P = 0.03). Elevated C-reactive protein levels predicted the need for revascularization. CONCLUSIONS: In this pilot trial, roxithromycin appears to extend the clinical benefit of preventing death and re-infarction for at least 6 months after initial treatment.  (+info)

Diagnostic marker cooperative study for the diagnosis of myocardial infarction. (8/1246)

BACKGROUND: Millions of patients present annually with chest pain, but only 10% to 15% have myocardial infarction. Lack of diagnostic sensitivity and specificity of clinical and conventional markers prevents or delays treatment and leads to unnecessary costly admissions. Comparative data are lacking on the new markers, yet using all of them is inappropriate and expensive. METHODS AND RESULTS: The Diagnostic Marker Cooperative Study was a prospective, multicenter, double-blind study with consecutive enrollment of patients with chest pain presenting to the emergency department. Diagnostic sensitivity and specificity and frequency of increase in patients with unstable angina were determined for creatine kinase-MB (CK-MB) subforms, myoglobin, total CK-MB (activity and mass), and troponin T and I on the basis of frequent serial sampling for +info)

*TIMI

"The TIMI Risk Score for Unstable Angina/Non-ST Elevation MI", JAMA, 2000 Antman, Elliott M.; Cohen, Marc; Bernink, Peter J. L. ... which assess the risk of death and ischemic events in patients experiencing unstable angina (UA) or a non-ST elevation ... "The TIMI Risk Score for Unstable Angina/Non-ST Elevation MI". JAMA. 284 (7): 835-42. doi:10.1001/jama.284.7.835. ISSN 0098-7484 ... At least 2 angina episodes within the last 24hrs ST changes of at least 0.5mm in contiguous leads Elevated serum cardiac ...

*Percutaneous coronary intervention

For patients with either non-ST-segment elevation myocardial infarction (nSTEMI) or unstable angina, treatment with medication ... The use of PCI in addition to anti-angina medication in stable angina may reduce the number of patients with angina attacks for ... PCI is also used in people after other forms of myocardial infarction or unstable angina where there is a high risk of further ... Finallly, PCI may be used in people with stable angina pectoris, particularly if the symptoms are difficult to control with ...

*Electrocardiography in myocardial infarction

Based on symptoms and electrocardiographic findings, practitioners can differentiate between unstable angina, NSTEMI and STEMI ... "The TIMI Risk Score for Unstable Angina/Non-ST Elevation MI: A Method for Prognostication and Therapeutic Decision Making". ... Because unstable ischemic syndromes have rapidly changing supply versus demand characteristics, a single ECG may not accurately ...

*Unstable angina

The pathophysiology of unstable angina is controversial. Until recently, unstable angina was assumed to be angina pectoris ... "unstable angina" at Dorland's Medical Dictionary Wiviott, S. D.; Braunwald, E (2004). "Unstable Angina and Non-ST-Segment ... the concept of unstable angina is being questioned with some calling for retiring the term altogether. Unstable angina is ... Unstable angina (UA) is a type of angina pectoris that is irregular. It is also classified as a type of acute coronary syndrome ...

*Intra-aortic balloon pump

Preoperative use is suggested for high-risk patients such as those with unstable angina with stenosis greater than 70% of main ... Unstable angina pectoris benefits from counterpulsation. Post cardiothoracic surgery-most common and useful is counterpulsation ...

*Myocardial infarction

Clinical guideline cg94: Unstable angina and NSTEMI. London, 2010. "UOTW #36 - Ultrasound of the Week". Ultrasound of the Week ... Unlike other causes of acute coronary syndromes, such as unstable angina, a myocardial infarction occurs when there is cell ... Plaques can become unstable, rupture, and additionally promote the formation of a blood clot that blocks the artery; this can ... Spasm of coronary arteries, such as Prinzmetal's angina may cause blockage. If impaired blood flow to the heart lasts long ...

*Management of acute coronary syndrome

... and unstable angina. Relief of the pain of angina is of paramount importance, not only for humane reasons but because the pain ... Unstable angina and non-ST elevation myocardial infarction". In Bonow RO; Mann DL; Zipes DP; Libby P. Braunwald's heart disease ... The principal symptom is typically chest pain, known as angina pectoris; people who present with angina must prompt evaluation ... the latter includes unstable angina and non-ST elevation myocardial infarction (NSTEMI). Treatment is generally more aggressive ...

*James S. Forrester (cardiologist)

His team discovered the presence of small, partially occlusive blood clots in patients with unstable angina (now called acute ... Cohen M, Fuster V (1990). "Insights into the pathogenetic mechanisms of unstable angina". Haemostasis. 20 (Suppl 1): 102-12. " ...

*Antianginal

They are not used in the treatment of unstable angina . In vitro, they dilate the coronary and peripheral arteries and have ... An antianginal is any drug used in the treatment of angina pectoris, a symptom of ischaemic heart disease. Drugs used are ... Nifedipine is more a potent vasodilator and more effective in angina. It is in the class of dihydropyridines and does not ... Short-acting nitrates are used to abort angina attacks that have occurred, while longer-acting nitrates are used in the ...

*Acute coronary syndrome

... "crescendo angina"). New-onset angina is also considered unstable angina, since it suggests a new problem in a coronary artery. ... In contrast with stable angina, unstable angina occurs suddenly, often at rest or with minimal exertion, or at lesser degrees ... Pollack CV, Sites FD, Shofer FS, Sease KL, Hollander JE (2006). "Application of the TIMI risk score for unstable angina and non ... The patient may still have suffered a "non-ST elevation MI" (NSTEMI). The accepted management of unstable angina and acute ...

*Iloprost

This is usually repeated every 8 to 12 weeks Contraindications: unstable angina; within 6 months of myocardial infarction; ...

*Wellens' syndrome

First described by Hein J. J. Wellens and colleagues in 1982 in a subgroup of patients with unstable angina, it does not seem ... March 1989). "Angiographic and clinical characteristics of patients with unstable angina showing an ECG pattern indicating ... coronary artery stenosis in patients with unstable angina. It is characterized by symmetrical, often deep (>2 mm), T wave ... "Anatomic and prognostic significance of new T-wave inversion in unstable angina". American Journal of Cardiology. 52 (1): 14-18 ...

*Mycoplasma hominis infection

"Detection of silent myocardial ischemia in asymptomatic selected population and in unstable angina". Advances in cardiology. 37 ...

*Coronary artery disease

Angina that changes in intensity, character or frequency is termed unstable. Unstable angina may precede myocardial infarction ... refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death. ... "unstable angina" is used. This process usually necessitates admission to hospital, and close observation on a coronary care ... "ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction ...

*Heparin

It is also used in the treatment of heart attacks and unstable angina. It is given by injection into a vein. Other uses include ...

*Prostacyclin receptor

For example, the IP agonist iloprost is contraindicated in patients with unstable angina; decompensated cardiac failure (unless ... However, PGI2 is very unstable, spontaneously converting to a far less active derivative 6-keto-PGF1 alpha within 1 minute of ...

*Diltiazem

Variant angina - it is effective owing to its direct effects on coronary dilation. Unstable angina (preinfarction, crescendo ... The drug is indicated for angina: Stable angina (exercise-induced) - diltiazem increases coronary blood flow and decreases ... Each of these effects results in reduced oxygen consumption by the heart, reducing angina symptoms. These effects also reduce ... angina pectoris, and some types of arrhythmia. It relaxes the smooth muscles in the walls of arteries, which opens (dilates) ...

*Coronary care unit

These units typically serve patients who require cardiac telemetry, such as those with unstable angina. Coronary care units ... As arrhythmias are relatively common in this group, patients with myocardial infarction or unstable angina are routinely ... unstable angina, cardiac dysrhythmia and (in practice) various other cardiac conditions that require continuous monitoring and ...

*N-terminal prohormone of brain natriuretic peptide

"Plasma N terminal pro-brain natriuretic peptide and cardiotrophin 1 are raised in unstable angina". Heart. 84 (4): 421-4. doi: ...

*Glycogen phosphorylase isoenzyme BB

A rapid rise in blood levels can be seen in myocardial infarction and unstable angina. Other enzymes related to glycogen ...

*Collateralization

64 had Q-wave infarction and 57 did not; 32 had unstable angina or subendocardial infarction. 74 totally occluded vessels and ... Whether angina causes collateral development is still debatable, but at least one investigator, Fujita, believes that angina is ... Fujita found that 2 of 19 patients without preinfarct angina had collaterals and 9 of 18 patients with angina had them. No ... Filling improved in 15 of 16 patients; neither chest pain nor pre-inflation angina correlated with the extent of collateral ...

*AA amyloidosis

"Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability". Institute ...

*Hyperhomocysteinemia

... arterial endothelial function in patients with unstable angina". The Indian journal of medical research. 129 (3): 279-84. PMID ...

*Francis M. Fesmire

"2011 ACCF/AHA focused update of the guidelines for the management of patients with unstable angina/non-ST-elevation myocardial ... "2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial ... "ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of ... Critical issues in the evaluation and management of patients with acute myocardial infarction or unstable angina". Annals of ...

*Kounis syndrome

This interferes with the blood flow to the heart muscle and causes symptoms otherwise indistinguishable from unstable angina. ... Kounis, NG; Zavras, GM (1991). "Histamine-induced coronary artery spasm: the concept of allergic angina". The British journal ...

*Cardiac catheterization

These comorbidity conditions include, aortic aneurysm, aortic stenosis, diabetes, obesity, renal insufficiency, unstable angina ... Unstable Angina) Abnormal Stress Test New-onset unexplained heart failure Survival of sudden cardiac death or dangerous cardiac ... arrhythmia Persistent chest pain despite optimal medical therapy Workup of suspected Prinzmetal Angina (coronary vasospasm) ...

*C-reactive protein

... the study group in this case consisted of patients who had been diagnosed with unstable angina pectoris; whether elevated CRP ...
A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction): Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine ...
Background: The presence of peripheral arterial disease (PAD) or cerebrovascular disease (CVD) increases the likelihood of significant coronary artery disease (CAD). The impact of PAD, CVD, prior CAD, or pre-existent disease in multiple arterial territories ("polyvascular" disease) in patients presenting with non-ST elevation acute coronary syndromes (ACS) has not been well studied.. Methods: A total of 95,749 patients enrolled from February 15, 2003 to September 30, 2006 at 484 sites in the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines (CRUSADE) registry were analyzed. Patients were categorized as having prior 0, 1, 2, or 3 affected arterial beds. The rates of in-hospital mortality, myocardial infarction (MI), stroke, and congestive (CHF) were analyzed, as were the rates of non-bypass surgery red blood cell transfusions.. Results: On presentation, a total of 11,345 (11.9%) patients had established PAD, ...
TY - JOUR. T1 - Pentraxin 3 in unstable angina and non-ST-segment elevation myocardial infarction. AU - Matsui, Shigeru. AU - Ishii, Junichi. AU - Kitagawa, Fumihiko. AU - Kuno, Atsuhiro. AU - Hattori, Kousuke. AU - Ishikawa, Makoto. AU - Okumura, Masanori. AU - Kan, Shino. AU - Nakano, Tadashi. AU - Naruse, Hiroyuki. AU - Tanaka, Ikuko. AU - Nomura, Masanori. AU - Hishida, Hitoshi. AU - Ozaki, Yukio. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Purpose: We prospectively investigated the prognostic value of pentraxin 3 (PTX3) in patients with unstable angina and non-ST-segment elevation myocardial infarction (UA/NSTEMI). Background: PTX3 may be a useful marker for localized vascular inflammation and damage to the cardiovascular system. Recent studies have shown that plasma PTX3 is elevated in patients with UA/NSTEMI; however, its prognostic value in UA/NSTEMI remains unclear. Methods: PTX3, high-sensitivity C-reactive protein (hsCRP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and cardiac ...
BACKGROUND: ST deviation and troponin are indicators of risk in unstable angina/non-ST-elevation myocardial infarction with related but distinct pathophysiology. We hypothesized that a combination of the two would offer complementary information rega
Stable vs Unstable Angina Stable angina and unstable angina are two clinical entities in cardiology caused by reduced blood supply to the heart muscle.
Video 24.8. Acute pulmonary embolism. TTE. Note dilated right heart with McConnells sign and paradoxical septal movements in a patient referred to the ER from the regional hospital due to suspected unstable angina. Echo-free space in front of the heart represents pericardial fat pad. Reproduced from Chapter 24: Echocardiography in the emergency room, in The EAE Textbook of Echocardiography. Edited by Leda Galiuto, Luigi Badano, Kevin Fox, Rosa Sicari, and Jose Luis Zamorano. © European Society of Cardiology. DOI: 10.1093/med/9780199599639.001.0001 The optimal therapy of patients presenting with unstable angina with or without enzyme rise but without ST elevation (UA/NSTEMI) is still debatable. Several (FRISC II, TACTICS-TIMI 18, RITA 3, ISAR-COOL, TIMACS), although not all (ICTUS, ELISA, OPTIMA, ABOARD, LIPSIA-NSTEMI), randomized trials have provided evidence in favour of an invasive strategy compared to conservative medical therapy in non-ST elevation acute coronary syndromes (NSTE-ACS). ...
Eugene Braunwald: Maestro Of American Cardiology pg. 7. For five "nail-biting" years, Braunwalds team waited for the results, which ultimately showed that patients who took pravastatin to lower serum cholesterol indeed reduced their risk for having another heart attack, stroke, or dying of cardiovascular causes.. More recent TIMI trials have examined the effect of driving cholesterol levels even lower, and have found not only that "lower is better," but that "much lower is much better." TIMI investigators are currently studying the effects of reducing a patients LDL to a level in the 50s, levels undreamed of ten years ago.. "Weve followed all of these patients extremely carefully and we dont see any serious side effects with even extreme cholesterol lowering," says Braunwald. "We have not yet reached the (LDL-concentration) floor.". For more than a half century as an academic physician-scientist, Braunwald has been instrumental in numerous discoveries that have saved millions of lives, and, ...
ABOARD: Angioplasty to Blunt the rise Of troponin in Acute coronary syndromes Randomized for an immediate or Delayed intervention. -Immediate versus Delayed Invasive Strategies in Patients with Non-ST Elevation ACS by Dr. Gilles Montalescot. ICTUS: Invasive Versus Conservative Treatment in Unstable Coronary Syndromes. -Early invasive strategy vs conservative, selective invasive strategy in troponin positive patients with non-STEMI ACS by Dr. Robbert J. De Winter. MATE: Medicine versus angiography in thrombolytic exclusion. -Triage angiography in suspected acute MI patients considered ineligible for reperfusion therapy by Dr. Peter A. McCullough. NRMI: National Registry of Myocardial Infarction. -Outcomes Among NSTEMI Patients Presenting to Hospitals With and Without Backup Cardiac Surgery by Dr. Yuri B. Pride. TACTICS TIMI 18: Treat Angina with Aggrastat + Determine Cost of Therapy with an Invasive or Conservative Strategy. -Treat Angina with Aggrastat + Determine Cost of Therapy with an ...
This is the first UK study to show that patients admitted to DGHs with unstable angina or NSTEMI and who are stratified at high risk wait significantly longer for angiography and revascularisation than similar patients admitted to a hospital containing a tertiary centre for cardiac services. Specifically, DGH patients were found to wait over two and a half times longer for angiography and over twice as long for revascularisation. The study hypothesis has therefore been proved.. The baseline characteristics of the MRI and DGH groups of patients were well matched except that more MRI than DGH patients had previously undergone coronary revascularisation. This is probably due to the fact that patients who have had a coronary procedure tend to represent to the hospital where they had it done and often remain under regular follow up at the tertiary centre. It is not clear why significantly more DGH patients had raised cholesterol.. If the "hit list" for invasive assessment and treatment of patients ...
Being unpredictable by nature, the pain can arise anywhere at any unexpected time and can, normally, last for 5-20 minutes. During unstable angina, no enzymes and bio markers of myocardial necrosis are released during unstable angina thereby making it to be an acute coronary syndrome. Symptoms related to unstable angina can be different for every individual. The most common symptoms include tightness or heaviness in the chest area, feeling of pain or pressure, a severe feeling originating in the thoracic region and spreading in neck, jaw, throat, arm and shoulder region, unease below the sternum (breast bone), breathlessness, trembling, and a heart burning sensation. The symptoms of unstable angina are somewhat similar to those of stable angina. But in view of the fact that unstable angina attacks a person all of a sudden, it might cause high levels of anxiety. Other associated symptoms include profuse sweating, nausea, and light headedness. It is advisable to take nitroglycerin so as to subside ...
Granger CB. Review: An early invasive strategy has similar benefits in men and women with NSTEMI or unstable angina. Ann Intern Med. 2008;149:JC5-7. doi: 10.7326/0003-4819-149-10-200811180-02007. Download citation file:. ...
article{d1a5f09c-7855-4503-ac4f-5599255a03dd, abstract = {,p,OBJECT: Subcutaneously intermittent administration of low molecular weight heparin (LMWH-Fragmin®) - (120IU/kgx2 BW) -in unstable angina has been introduced clinically during the last year, after reports of the FRISC and FRIC studies as an alternative to continous infusion of standard heparin. Fragmin® could possible endanger postoperative haemostasis after CABG due to uncomplete reversal of anti-Xa effects with protamine and an increased rise for heparin-rebound due to its longer half-life. METHODS: Thirty consecutive unstable angina patients undergoing CABG were studied. Sonoclot coagulation analyses (Sienco, USA) and Hemochrone®-ACT, routine coagulation and haematological analyses and anti-Xa analyses were performed pre and postoperatively. Patients were randomized into two groups for postoperative haemostasis correction. If bleeding exceeded 100 ml after the first hour in the intensive care unit, one group recieved a continous ...
Rx unstable angina: Immediate aggressive treatment to prevent final heart attack = angina is the precursor to mi. Angina is when heart oxygenation not able to provide support to the degree of daily activities for the person. A lot of mi heart attack) without even a warning sign of angina. 50% of mi result in immediate death. No time to waste. Sx vary a lot from person to person. Sudden stomach pain sx can be angina. ...Read more See 1 more doctor answer ...
What is the impact of metabolic syndrome (MS) on long-term clinical outcomes in patients with pure non−ST-segment elevation myocardial infarction (NSTEMI) or unstable angina pectoris (USAP)?. ...
An increased tissue endothelin-1 (ET-1) immunoreactivity has been demonstrated at the site of the culprit lesion (CL) in patients with unstable angina (UA) thus suggesting that ET-1 may be involved in the abnormal vasoreactivity of the CL in UA. The aim of this study was to establish whether an enhanced local release of ET-1 is involved in the pathogenesis of the enhanced vasoreactivity of the unstable plaque in patients with UA. We studied 9 patients with UA and 9 patients with stable angina (SA) with a single proximal lesion of the left anterior descending coronary artery. Luminal diameter of the CL and of the proximal, middle and distal normal-appearing coronary segments were measured by quantitative coronary angiography at baseline, during cold pressor test (CPT) and after intracoronary administration of nitroglycerine (NTG). ET-1 levels were measured in blood samples obtained proximally and distally to the coronary CL before and after successful stent implantation. During CPT, the CL in ...
During inflammation, reactive oxygen species promote the adhesion of blood cells to the vascular endothelium by eliciting production of inflammatory mediators or activating nuclear transcription factors that bind to genes encoding adhesion molecules and cytokines.32,33 CD40-40L signaling represents another pathway that enables blood cells to amplify the endothelial cell responses to inflammation and contribute to the regulation of hemostasis.7 Platelets can indirectly orchestrate (through CD40-40L interaction via the endothelium) changes in coagulation, leukocyte trafficking, and extracellular matrix modeling turnover.34 CD40L has been associated also with numerous vascular diseases including diabetes and acute coronary syndromes.35-41 In recent studies, the prognostic values of serum sCD40L in acute coronary syndromes42 and in unstable angina patients8 has been reported.. Reports of sCD40L release by platelets5,7 have led to studies examining the mechanism of CD40L expression,15 release,43,44 ...
Another name for Unstable Angina is Angina. The long-term treatment of angina depends on the severity of the coronary artery disease, the condition of ...
Among elderly patients with NSTE-ACS, invasive therapy was beneficial at reducing adverse cardiovascular events compared with conservative therapy. This was due to a reduction in recurrent MI and urgent revascularization procedures. There was suggestion of harm for patients ,90 years of age; however, definitive conclusions in this group were not possible due to the limited number of patients. This trial is unique in that no crossovers occurred between the treatment groups, unlike previous trials in which a large proportion of conservative patients underwent angiography. Elderly patients are at high risk for adverse events after a NSTE-ACS, and invasive therapy remains the optimal treatment to reduce this risk.. ...
The Thrombolysis In Myocardial Infarction, or TIMI Study Group is an Academic Research Organization (ARO) affiliated with Brigham and Womens Hospital and Harvard Medical School. The group has its headquarters in Boston, Massachusetts, and a satellite location in Quincy. The TIMI Study Group was founded by Eugene Braunwald, MD in 1984. Dr. Braunwald held the chairmanship until 2010, when he appointed Marc Sabatine, MD to the position. The group has conducted numerous practice-changing clinical trials in patients with cardiovascular disease or risk factors for cardiovascular disease. Among the groups most important contributions to medicine is the TIMI Risk Score, which assess the risk of death and ischemic events in patients experiencing unstable angina (UA) or a non-ST elevation myocardial infarction (NSTEMI). In patients with UA/NSTEMI, the TIMI risk score is a simple prognostication scheme that categorizes a patients risk of death and ischemic events and provides a basis for therapeutic ...
Another name for Unstable Angina is Angina. Facts about angina: * Heart disease is the leading cause of death in the United States. * Over two million ...
Diabetes mellitus is an etiologically and clinically heterogeneous group of metabolic disorders that share the commonality of hyperglycemia. Long-term hyperglycemia produces tissue damage, which ultimately manifests as microvascular and macrovascular disease, and neuropathy. The presence of macrovascular disease should alert clinicians to the possibility that the patient may have coronary artery disease, particularly because coronary artery disease and myocardial ischemia are likely to be silent. Elderly patients with diabetes mellitus are also more likely to develop congestive heart failure. Patients with unstable coronary syndromes, decompensated heart failure, and symptomatic cardiac arrhythmias are at increased risk of perioperative cardiovascular complications (myocardial infarction, heart failure, and sudden death) while undergoing noncardiac procedures. In addition, clinicians must avoid the risk of hypoglycemic episodes. Oral health care providers can expect to be called upon to care for ...
Chest pain is a nonspecific symptom that can have cardiac or noncardiac causes (see DDx). Unstable angina belongs to the spectrum of clinical presentations referred to collectively as acute coronary syndromes (ACSs), which range from ST-segment elevation myocardial infarction (STEMI) to non-STEMI (NSTEMI).
Chest pain is a nonspecific symptom that can have cardiac or noncardiac causes (see DDx). Unstable angina belongs to the spectrum of clinical presentations referred to collectively as acute coronary syndromes (ACSs), which range from ST-segment elevation myocardial infarction (STEMI) to non-STEMI (NSTEMI).
This guideline covers treatments for people aged 18 and over with unstable angina (recurring chest pain) or a type of heart attack called non-ST-segment-elevation myocardial infarction (NSTEMI). It aims to ensure that people get treatment quickly.
A retrospective study was made of 158 patients with unstable angina admitted to a coronary care unit over a 4-year period. Twenty patients (13 per cent) had myocardial infarcts while in hospital, and of these 3 died; three others died without preceding evidence of myocardial infarction. There was thus an acute mortality rate of 4 per cent. Patients with persisting angina after the first 24 hours and those without a previous history of myocardial ischaemia were more likely to develop a myocardial infarct or to die in hospital. Follow-up information, ranging from 3 to 7 years, was available in 144 of 152 hospital survivors. Patients older than 60 years (P less than 0-05), with cardiomegaly (P less than 0-01) and with pulmonary venous congestion (P less than 0-05) were found to have significantly increased long-term mortality. Long-term mortality was also found to rise with increasing coronary prognostic index. The average mortality rate for the whole group of hospital survivors was about 5 per ...
Unstable angina or sometimes referred to as acute coronary syndrome causes unexpected chest pain, and usually occurs while resting. The most common cause is reduced blood flow to the heart muscle because the coronary arteries are narrowed by fatty buildups (atherosclerosis) which can rupture causing injury to the coronary blood vessel resulting in blood clotting which blocks the flow of blood to the heart muscle ...
Covers causes of heart attack (myocardial infarction) and unstable angina. Discusses symptoms like chest pain or pressure. Explains MI and angina differences. Offers prevention tips. Covers diagnostic tests and treatment with medicines and surgery.
Covers causes of heart attack (myocardial infarction) and unstable angina. Discusses symptoms like chest pain or pressure. Explains MI and angina differences. Offers prevention tips. Covers diagnostic tests and treatment with medicines and surgery.
Covers causes of heart attack (myocardial infarction) and unstable angina. Discusses symptoms like chest pain or pressure. Explains MI and angina differences. Offers prevention tips. Covers diagnostic tests and treatment with medicines and surgery.
The choice of an "invasive" or "conservative" strategy for the initial management of patients with acute coronary syndromes (ACSs) has been evaluated in 7 RCTs, the results of which have been summarized by 2 groups using meta-analysis. Although it seems that the 2 meta-analyses reached different conclusions, both groups supported the invasive strategy in their respective discussion sections. Several trial limitations have confused the debate on what used to be a contentious subject, but the evidence now favors percutaneous coronary intervention (PCI) for NSTEMI. First, the terms that describe the strategies need to be clarified. The "invasive strategy" refers to the routine use of cardiac catheterization, not coronary revascularization with PCI or coronary artery bypass graft (CABG) surgery. The "conservative strategy" limits the use of cardiac catheterization to patients with spontaneous or provokable ischemia, but the term does not convey the fact that 50% of patients allocated to this ...
GlobalData, the industry analysis specialist, has released its new report, Unstable Angina Therapeutics - Pipeline Assessment and Market Forecast to 2018. The report is an essential source of information and analysis on the global Unstable Angina Therapeutics market. The report identifies the key trends shaping and driving the global Unstable Angina Therapeutics market. The report also provides insights on the prevalent competitive landscape and the emerging players expected to significantly alter the market positioning of the current market leaders. Most importantly, the report provides valuable insights on the pipeline products within the global Unstable Angina Therapeutics sector. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts.
Unstable angina is a potentially dangerous condition, and management should be tailored to prevent adverse outcomes. Patients should be admitted to the cardiac care unit, placed at bedrest, and begun on antianginal therapy with either P-blockers or calcium channel blockers, aspirin, and intravenous nitrates. (J-Blockers, when added to nitrates, have been shown to reduce symptoms […] Read more. ...
Learn about the drug Antiplatelet Medicine for Heart Attack and Unstable Angina. Includes generic and brand name examples, dosage, how the drug works, why it is used and side effects.
Unstable Angina and NSTEMIs: Management Principles. Meira Louis Lisa Campfens. Outline. Pick your/ cardios strategy Initial therapy...for everyone? Pick an anti-platelet...or two...or three... Protect the stomach??? PPI controversy Pick the right anti-coagulant Slideshow 2224058...
The clinical and pathologic findings in this case are interpreted as follows. A remote episode of transient ischemia in the distribution of the right coronary artery led to subepicardial foci of replacement fibrosis. No clinical events had been noted that correlated with these lesions. Two to three weeks before death, ulceration of the fibrous cap of an atherosclerotic plaque in the right coronary artery produced embolization of atheromatous debris, nonocclusive thrombosis on the ulcerated plaque and development of focal ischemic subepicardial necroses in the distribution of the artery. About 2 to 3 days before death, focal contraction band necrosis, attributed to coronary artery spasm, developed in the same subepicardial distribution. Death was probably due to another episode of arterial spasm at the site of the plaque that caused a prolonged episode of severe chest pain and precipitated a lethal arrhythmia. The rapidity of death would not allow time for the development of pathologically ...
Find out all information about angina at rest also known as unstable angina. This condition is marked by chest pain which appears while person is at rest
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The arteries that bring blood to the heart muscle (coronary arteries) can become clogged by plaque (a buildup of fat, cholesterol and other substances). Disease develops when a combination of fatty material, calcium, and scar tissue (plaque) builds up in the arteries that supply the heart with blood.
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My chest pains started up again about 2 months ago after 9 months without. I had one really bad attack, but then went for 10 days with hardly any. Thursday and Friday I had prolonged low-grade chest ...
To the best of our knowledge, there have been no studies investigating the association among diabetes, angiogenic factors, and oxidative stress in human heart tissue affected by ischemic insult. The main findings of our study demonstrate an association between diabetes, reduced expression of HIF-1α and VEGF, and increment of iNOS, O2−, and nitrotyrosine levels in heart specimens of patients with unstable angina. Diabetes amplifies oxidative reaction and worsens the angiogenic process. In nondiabetic patients, we detected increased steady-state levels of HIF-1α and VEGF after unstable angina. This accumulation of both mRNA and protein was limited to the region of affected myocardium. No HIF-1α and VEGF transcripts or proteins were detectable in nonischemic specimens. In diabetic patients, the picture is quite different because both HIF-1α and VEGF levels were significantly lower than those in nondiabetic heart specimens. Thus, the roles of HIF-1α and VEGF in beginning angiogenic process ...
Sigma-Aldrich offers abstracts and full-text articles by [Ke-Fei Dou, Bo-Qia Xie, Xiao-Jin Gao, Yan Li, Yue-Jin Yang, Zuo-Xiang He, Min-Fu Yang].
2006 (Swedish)In: Läkartidningen, ISSN 0023-7205, Vol. 103, no 30-31, 2240-1; discussion 2241 p.Article in journal (Refereed) Published ...
Fibrin, Plasma, 1,4-butanediamine, Homocysteine, Plasminogen, Cardiac Death, Concentration, Death, Infarction, Myocardial Infarction, Stroke, Unstable Angina, Adp, ATP, Collagen, Estradiol, Estrogenic Effects, Hand, Methods, Orientation
References: Anderson JL, Adams CD, Antman EM, et al. ACC/AHA Guidelines for the Management of Patients With Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina). Circulation. 2007;116:803-877.. Goldman L. Approach to the patient with possible cardiovascular disease. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 50.. Sabatine MS, Cannon CP. Approach to the patient with chest pain. In: Bonow RO, Mann DL, Zipes DP, Libby P, eds. Braunwalds Heart Disease: A Textbook of Cardiovascular Medicine. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 53.. Wright RS, Anderson JL, Adams CD, et al. 2011 ACCF/AHA Focused Update of the Guidelines for the Management of Patients with Unstable Angina/Non-ST-Elevation Myocardial Infarction (Updating the 2007 Guideline). ...
The present study specifically assessed whether a relation exists between serum neopterin concentration, a marker of macrophage activity, and angiographically demonstrated complex stenoses in patients with unstable angina pectoris. Compared with patients with stable angina pectoris, those with unstable angina have a higher number of complex coronary lesions (22,25). It has been shown that the progression of these stenoses is faster than that of smooth stenoses. A larger proportion of complex stenoses, as compared with smooth stenoses, progress rapidly in both patients with stabilized unstable angina (21) and those with chronic stable angina (14). It has been suggested that angiographically demonstrated complex lesions represent vulnerable plaques prone to disruption or truly disrupted plaques (5,6,22). Plaque vulnerability is a function of the increased number of macrophages and activated lymphocytes (4). Coronary plaques of patients with unstable angina have more extensive macrophage-rich areas ...
Objectives: This study sought to investigate long-term outcomes after early or delayed angiography in patients with non-ST-segment elevation acute coronary syndrome (nSTE-ACS) undergoing a routine invasive management. Background The optimal timing of angiography in patients with nSTE-ACS is currently a topic for debate.. Methods: Long-term follow-up after early (within 2 days) angiography versus delayed (within 3 to 5 days) angiography was investigated in the FRISC-II (Fragmin and Fast Revascularization During Instability in Coronary Artery Disease), ICTUS (Invasive Versus Conservative Treatment in Unstable Coronary Syndromes), and RITA-3 (Intervention Versus Conservative Treatment Strategy in Patients With Unstable Angina or Non-ST Elevation Myocardial Infarction) (FIR) nSTE-ACS patient-pooled database. The main outcome was cardiovascular death or myocardial infarction up to 5-year follow-up. Hazard ratios (HR) were calculated with Cox regression models. Adjustments were made for the FIR risk ...
The paradoxical use of cardiac catheterization in patients with non-ST-elevation acute coronary syndromes: lessons from the Can Rapid Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC /AHA Guidelines (CRUSADE) Quality Improvement Initiative.
Most patients with a non-ST elevation acute coronary syndrome (unstable angina and non-ST elevation myocardial infarction) undergo coronary angiography and revascularization during the index hospitalization. This topic will summarize the evidence sup
Our finding that mean platelet component is lower in acute myocardial infarction than in unstable angina, reflecting greater platelet activation, confirms the central role of thrombogenicity in the pathogenesis of acute coronary syndromes. Indeed, platelet activation was an independent predictor of the mode of presentation and, even in the subgroup of patients with unstable angina at high risk of future events, platelet activation was significantly lower than in those with myocardial infarction.. Some studies have not found a difference in platelet activation between unstable angina and myocardial infarction. However, Garlichs and colleagues2 found greater expression of the CD40 ligand in unstable angina than in myocardial infarction. This appears counterintuitive but may reflect greater hydrolysis and release of the ligand in myocardial infarction. Mathur and colleagues3 found a greater expression of P selectin in myocardial infarction than in unstable angina but also found that mean platelet ...
BACKGROUND: Unstable angina and non-ST elevation myocardial infarction (NSTEMI) are common acute coronary events. Homocysteine is a novel risk factor for coronary heart diseases. Together with the conventional risk factors, they may affect the outcom
Objective: To analyse intensity of treatment of high-risk patients with non-ST elevation acute coronary syndromes (NSTEACS) included in the DESCARTES (Descripción del Estado de los Sindromes Coronarios Agudos en un Registro Temporal Español) registry.. Patients and setting: Patients with NSTEACS (n = 1877) admitted to 45 randomly selected Spanish hospitals in April and May 2002 were studied.. Design: Patients with ST segment depression and troponin rise were considered high risk (n = 478) and were compared with non-high risk patients (n = 1399).. Results: 46.9% of high-risk patients versus 39.5% of non-high-risk patients underwent angiography (p = 0.005), 23.2% versus 18.8% (p = 0.038) underwent percutaneous revascularisation, and 24.9% versus 7.4% (p , 0.001) were given glycoprotein IIb/IIIa inhibitor. In-hospital and six-month mortality were 7.5% versus 1.1% and 17% versus 4.6% (p , 0.001), respectively. A treatment score (⩾ 4, 2-3 and , 2) was defined according to the number of class I ...
During the past few decades two treatment strategies have evolved for patients with unstable coronary artery disease (UCAD). The non-invasive strategy uses clinical investigations and non-invasive stress tests to identify patients who need diagnostic catheterisation. The early invasive strategy uses coronary catheterisation as the diagnostic instrument. The new technologies have consequences not only for the clinical endpoints of death or myocardial infarction (MI), but also in terms of health-related quality of life and costs. The economic evaluations are of great importance due to the high incidence of the disease and high short-term costs of the invasive strategy. The early costly intervention may prevent later complications and thereby partly or completely offset the higher initial treatment costs. Even if longterm costs remain higher, they can be justified by improved survival or quality of life. Such clinical effects in the long-term follow-up need to be seen in relation to the cost of the ...
Unstable angina: This may be a new symptom or a change from stable angina. The angina may occur more frequently, occur more easily at rest, feel more severe, or last longer. Although this can often be relieved with oral medications (such as nitroglycerin), it is unstable and may progress to a heart attack. Usually more intense medical treatment or a procedure are required to treat unstable angina. Non-ST segment elevation myocardial infarction (NSTEMI): This type of heart attack, or MI, does not cause major changes on an electrocardiogram (ECG). However, chemical markers in the blood indicate that damage has occurred to the heart muscle. In NSTEMI, the blockage may be partial or temporary, so the extent of the damage is usually relatively small. ST segment elevation myocardial infarction (STEMI): This type of heart attack, or MI, is caused by a sudden blockage in blood supply. It affects a large area of the heart muscle, and causes changes on the ECG as well as in blood levels of key chemical ...
Chest pain is considered the major clinical presentation of patients with acute coronary syndromes. The significant number of patients with acute coronary syndrome who do not have chest pain on initial presentation are at risk for receiving less aggressive care. Improved recognition of atypical symptoms of acute coronary syndrome may lead to more rapid treatment. Canto and associates used a retrospective review to determine the proportion of patients admitted with unstable angina pectoris who presented with atypical symptoms and to better characterize atypical presentations of the condition.. The study used data from the Alabama Unstable Angina Study of Medicare beneficiaries, which included patients hospitalized from 1993 to 1999, to review the presenting characteristics of persons with confirmed unstable angina pectoris.. Typical presentation included substernal chest pain and chest pain aggravated by exercise or relieved with rest or nitroglycerin. Atypical presentation was defined as the ...
BACKGROUND: Data are limited on whether clinical trials have randomized higher-risk patients over time and how trends in risk profiles and evidence-based pharmacotherapies have influenced trial outcomes. We quantified changes in baseline risk, treatment, and outcomes of patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) randomized in 9 phase 3 clinical trials of antithrombotic therapy over 15years. METHODS: We studied 58,771 patients in GUSTO IIb, PURSUIT, PARAGON-A, PARAGON-B, PRISM, PRISM-PLUS, GUSTO IV-ACS, SYNERGY, and EARLY ACS. Patient-level data were mapped to 3 pre-specified 5-year randomization periods. Temporal trends in GRACE score-predicted mortality were compared with trends in observed mortality. RESULTS: Over time, in-hospital and discharge use of thienopyridines (p=0.001), statins (p,0.0001), and angiotensin-converting enzyme inhibitors (p,0.0001) increased, and hospital length-of-stay decreased (p=0.024). Blood transfusion use increased (8.3% [1994-98], ...
In the current propensity‐matched analysis of contemporary real‐life data, an early invasive strategy was associated with an increased in‐hospital survival in NSTE‐ACS patients with concomitant DM. These results support the 2014 ACCF/AHA guideline recommendations for an early invasive strategy in diabetics, especially those with high‐risk features (eg, NSTEMI and cardiogenic shock).10 Meanwhile, the use of this strategy in lower risk patients, such as those with UA, may not be associated with improved survival.. The survival benefit of an early invasive strategy in the NSTE‐ACS population remains a matter of ongoing debate.20, 21, 22 Whereas none of the landmark trials comparing an early invasive with an initial conservative strategy illustrated a statistically significant reduction in mortality, these trials were not statistically powered to answer that question.21, 22, 23, 24 We calculated the minimal sample size required by a randomized trial to detect the difference in ...
BACKGROUND: 12-lead ECG monitoring of the ST segment is more sensitive than patients symptoms for detecting ischemia after thrombolytic therapy or catheter-based interventions, but it is unclear whether monitoring of the single lead showing maximum ST deviation would be as efficacious. OBJECTIVE: To determine whether monitoring all 12 ECG leads for changes in the ST segment is necessary to detect ongoing ischemia in patients with unstable coronary syndromes. METHODS: Continuous 12-lead ST segment monitoring was performed in 422 patients from the onset of myocardial infarction or during balloon inflation in catheter-based interventions until the patients discharge from the cardiac care unit. Computer-assisted techniques were used to determine (1) which lead showed the maximum ST deviation at the onset of myocardial infarction or during balloon inflation and (2) what proportion of later ischemic events were associated with ST deviation in this lead. RESULTS: The lead with the maximum ST ...
The correlation between persistent negative T wave on basal electrocardiogram and coronary anatomy or global and regional left ventricular function was investigated in 34 patients with unstable angina defined as new onset (| 2 months), crescendo or rest angina. The patients with history of previous myocardial infarction, pathological Q waves on electrocardiogram or documented elevation of CPK were excluded. Eighteen patients (group A) showed T wave inversion (| 1 mV) in at least two leads on the basal electrocardiogram, persisting for at least 48 hours before coronary arteriography. In 16 patients (group B) the basal electrocardiogram was normal. Left ventricular volumes and ejection fraction were calculated and the regional systolic wall motion was analyzed using the area method in the 30 degrees right anterior oblique view. Hypokinesis was defined as more than 2 standard deviation below the mean value calculated in 24 normal subjects. No difference was present for age (A: 61 +/- 9 vs B: 57 +/- 9 yrs)
Coronary syndromes vary in severity, ranging from unstable angina, non-ST segment elevation myocardial infarction (NSTEMI), to ST-segment elevation myocardial infarction (STEMI), the most severe diagnosis. Little data exist about changing trends in acute myocardial infarction and whether death rates are increasing or decreasing.
Q: For several years my husband has had anginal chest pains due to a bad heart. Recently he was hospitalized with a diagnosis of unstable angina. I would like to know the difference between regular
Looks at medicines to help people who have unstable angina or those having a heart attack. Lists generic and brand names such as metoprolol (Lopressor) and penbutolol (Levatol). Covers how they work and side effects.
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...PARSIPPANY N.J. and INDIANAPOLIS March 29 2011 /- Oral... Class I means that a given procedure/treatment should be performed/...Effient tablets are approved by the U.S. Food and Drug Administration ...The guidelines also include the following recommendations for the use ...,Effient®,Added,to,Updated,ACCF/AHA,Clinical,Guidelines,for,ACS-PCI,Patients,with,Unstable,Angina,and,Non-ST,Segment,Myocardial,Infarction,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
BACKGROUND: The long-term outcome of an interventional strategy in patients with non-ST-elevation acute coronary syndrome is unknown. We tested whether an interventional strategy (routine angiography followed by revascularisation) was better than a conservative strategy (ischaemia-driven or symptom-driven angiography) over 5 years follow-up. METHODS: In a multicentre randomised trial, 1810 patients (from 45 hospitals in England and Scotland, UK) with non-ST-elevation acute coronary syndrome were randomly assigned to receive an early intervention (n=895) or a conservative strategy (n=915) within 48 h of the index episode of cardiac pain. In each group, the aim was to provide the best medical treatment, and also to undertake coronary arteriography within 72 h in the interventional strategy with subsequent management guided by the angiographic findings. Analysis was by intention to treat and the primary outcome (composite of death or non-fatal myocardial infarction) had masked independent ...
Your heart muscle is working all the time, so it needs a constant supply of oxygen. This oxygen is provided by the coronary arteries, which carry blood.. When the heart muscle has to work harder, it needs more oxygen. Symptoms of angina occur when the coronary arteries are narrowed or blocked by hardening of the arteries (atherosclerosis), or by a blood clot.. The most common cause of angina is coronary heart disease (CHD). Angina pectoris is the medical term for this type of chest pain.. Stable angina is less serious than unstable angina, but it can be very painful or uncomfortable.. There are many risk factors for coronary heart disease. Some include:. ...
The global angina pectoris drugs market is expected to be valued at USD 10.6 Billion by 2022, as per a new report by Grand View Research, Inc. The global angina pectoris market is collectively driven by demand for disease-modifying and targeted treatments, increased expenditure on healthcare and availability of effective treatment methods across the emerging markets.. (Logo: http://photos.prnewswire.com/prnh/20160524/371361LOGO ) Additionally, the rising prevalence and incidence of angina pectoris is anticipated to fuel the market growth. Chronic stable angina pectoris has a prevalence of 2.0-4.0% in developed markets such as the U.S., the U.K., Germany, France, Italy, Spain and Japan. The prevalence of angina pectoris rises sharply with age in both genders, ranging from 2.0- 5.0% in men aged 45-54 to 10.0-20.0% in men aged 65-74, and from 0.1-1.0% in women aged 45-54 to 10.0-15.0% in women aged 65-74. The disease symptoms can be managed by following a healthy lifestyle.. Browse full research ...
Angina is the medical term used to describe the sharp, crushing pain that one experiences when there is a limited supply of blood to the heart causing the latter to be deprived of much needed oxygen. In most cases, the angina can be felt in the chest and can radiate towards the limbs. Most medical professionals do not treat angina as a disease on its own. Instead, it is seen as a sign or a symptom of an even more serious heart condition such as Coronary Heart Disease, or what most people refer to as CHD. In a CHD, there is a build up of plaque along the walls of the arteries. This causes narrowing of the path where the oxygen-rich blood can pass through.. Although most people see angina as only one kind, there is actually four major types of angina that a person might suffer from. Of these four, it is the stable angina that is considered to be the most common. In a stable angina, the onset is pretty much predictable. For one, a stable angina typically takes place only after too much physical ...
A heart attack and myocardial infarction (MI) are commonly used terms, and mean the same thing. However, the term MI is used less often now by doctors. This is because there is actually a range of conditions that can be caused by a sudden reduction in blood flow in a coronary artery. This range of conditions has an overall term called acute coronary syndrome (ACS).. Two main sub types of ACS can be diagnosed by what is seen on your heart tracing (electrocardiograph, or ECG). The two main types are called ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI). The ST elevation refers to a section on the ECG tracing.. NSTEMI can also include unstable angina. Most people with angina chest pains only have pain with a certain amount of exertion. This is called stable angina. If the pattern of your pain changes suddenly and the pains develop after minimal exertion, or while you are resting, this is called unstable angina. This is an emergency and needs immediate medical care. See separate leaflet ...
In simple terms, refractory angina (RFA) is a disabling chronic heart pain, as a result of heart disease. Angioplasty, coronary artery bypass surgery, or even medical therapy have failed to control this chest pain. A chronic chest pain can be determined if it occurs longer than three months. The blockage of arteries takes place due to a build-up of plaque. As a result, blood flow slows down and makes it hard for oxygen-rich blood to reach the heart. This causes angina or chest pain. Those suffering from angina may experience back, neck, shoulder, arm, or jaw pain. Those with RFA have angina symptoms that are more severe and difficult to manage than those who experience regular stable angina. The symptoms are usually unmanageable; however, there are few specialized treatments that can aid in reducing the severity of the symptoms. A non-invasive therapy known as Enhanced External Counter Pulsation (EECP) places compressive cuffs on the upper and lower legs (calves, upper, and thighs). Along with ...
Cathy suffers from unstable angina pectoris and has had one pre-heart attack. Hi! I am Cathy and 68 years old. Independence is the most important thing
Acute Coronary Syndromes OVERVIEW coronary artery disease accounts for | 30% of death in West CLASSIFICATION unstable angina: ischaemic pain that is more severe, frequent or prolonged than normal MI: ischaemic symptoms + raised biomarkers (NSTE-ACS and STE-ACS) ASSESSMENT HISTORY take pain history assess severity recent MI previous thrombolysis, stent or CABG CHF symptoms functional…
Doctors Ask: There are many reasons why the blood pressure is leaking. Fluctuations of pressure often depend on the gender, age, lifestyle of the patient and even his benefits to food. Today, the notion of acute coronary syndrome is widely used in urgent cardiology. This concept involves distinguishing from the outside, according to clinical manifestations, sharp variants of the course of coronary heart disease - myocardial infarction and unstable angina.
A coronary care unit (CCU) or cardiac intensive care unit (CICU) is a hospital ward specialized in the care of patients with heart attacks, unstable angina, cardiac dysrhythmia and (in practice) various other cardiac conditions that require continuous monitoring and treatment. The main feature of coronary care is the availability of telemetry or the continuous monitoring of the cardiac rhythm by electrocardiography. This allows early intervention with medication, cardioversion or defibrillation, improving the prognosis. As arrhythmias are relatively common in this group, patients with myocardial infarction or unstable angina are routinely admitted to the coronary care unit. For other indications, such as atrial fibrillation, a specific indication is generally necessary, while for others, such as heart block, coronary care unit admission is standard. In the United States, cardiac conditions accounted for eight of the eighteen conditions and procedures with high ICU utilization (ICU utilization in ...
The American Heart Association explains that acute coronary syndrome is an umbrella term for situations where the blood supplied to the heart muscle is suddenly blocked such as heart attack and unstable angina.
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Editor,-I enjoyed the prospective study by Cooke et al (Gut1998;42:323-329) on the relation between oesophageal abnormalities and chest pain in patients with normal coronary angiograms and with angina pectoris. This study confirms the findings of previous studies1 2 that the oesophagus is responsible for chest pain in a high percentage of patients with coronary artery disease, and that an episode of gastro-oesophageal reflux nearly always triggers this pain.. However, no explanation for this unexpected finding has been given. The tentative proposition that it is the result of a decreased angina threshold3 and a reflex coronary ischaemia, both induced by the contact of acid with the oesophageal mucosa, is not acceptable for two reasons: firstly, because this oesophagocardiac reflex may be the basis for linked angina but not for oesophageal angina and, secondly, because the patients should have shown simultaneous electrocardiographic (ECG) abnormalities during the pain induced by the acid ...
Angina - MedHelps Angina Center for Information, Symptoms, Resources, Treatments and Tools for Angina. Find Angina information, treatments for Angina and Angina symptoms.
The classification scheme for unstable angina was established by Braunwald. A totally occluded clot produces AMI. Both AMI and UA, can produce chest pain at rest, lead to changes in electrocardiogram and release of enzymes and proteins into blood. In Angina there is partial blockage leading to severe compressive referred chest pain at rest or excursion and in AMI there is large blockage causing necrosis, infarction, also has similar symptoms plus biochemical findings. ...
An episode of angina does not indicate that a heart attack is occurring, or that a heart attack is about to occur. Angina does indicate, however, that coronary heart disease is present and that some part of the heart is not receiving an adequate blood supply. Persons with angina have an increased risk of heart attack.. A person who has angina should note the patterns of his or her symptoms--what causes the chest pain, what it feels like, how long episodes usually last, and whether medication relieves the pain. Call for medical assistance if the angina episode symptoms change sharply.. ...
OBJECTIVE--To assess the effects of calcium channel blockers on development of infarcts, reinfarction, and mortality. DESIGN--A systematic overview of all randomised trials of calcium channel blockers in myocardial infarction and unstable angina. PATIENTS--19,000 Patients in 28 randomised trials. RESULTS--In the trials of myocardial infarction 873 deaths occurred among 8870 patients randomised to active treatment compared with 825 deaths among 8889 control patients (odds ratio of 1.06, 95% confidence interval of 0.96 to 1.18). There was no evidence of a beneficial effect on development and size of infarcts or rate of reinfarction. The results were similar in short term trials in which treatment was confined to the acute phase and those in which treatment was started some weeks later and continued for a year or two. There was no evidence of heterogeneity among different calcium channel blockers in their effects on any end point. The results were similar in the unstable angina trials (110 out of ...
NEW WHITE PAPER REVEALS CARDIOVASCULAR PANDEMIC AFFECTING TENS OF MILLIONS OF PEOPLE WORLDWIDE. SAN DIEGO, CA March 6, 2015 - Critical Diagnostics reported today that it has issued a White Paper titled, "The Pandemic Called Heart Failure." It is a contemporary look at the problem of heart failure, examining its global prevalence, why it will be a mounting problem for years to come, the economic and social impact it will have, and the outlook for heart failure and heart failure care in the future.. Dr. Eugene Braunwald, whose contributions to the field of cardiology are unparalleled, recently called heart failure a "pandemic." In his seminal paper, "The war against heart failure: the Lancet lecture," published in 2014, Braunwald declared, "the pandemic of heart failure represents a major global health problem . . . A concerted series of actions are needed to deal with this problem, hence the war against heart failure.". Despite major improvements in the treatment of virtually all cardiac ...
The Isfahan Cohort Study (ICS) was a population-based, longitudinal study of 6504 adults aged 35 years old or more. The subjects were recruited from urban and rural areas of three districts in central Iran consisting of Isfahan, Najafabad, and Arak from January to September 2001. The participants were followed biannually in order to detect major cardiovascular events including myocardial infarction, unstable angina pectoris, stroke, and sudden cardiac death until 2011. Baseline laboratory and clinical measurements were repeated in 2007; and for a subsample in 2013.. ...
OverviewThe Isfahan Cohort Study (ICS) was a population-based, longitudinal study of 6504 adults aged 35 years old or more. The subjects were recruited from urban and rural areas of three districts in central Iran consisting of Isfahan, Najafabad, and Arak from January to September 2001. The participants were followed biannually in order to detect major cardiovascular events including myocardial infarction, unstable angina pectoris, stroke, and sudden cardiac death until 2011.
Special precautions: In ischemic heart disease, a deterioration of cardiac function and a decrease in coronary blood flow could theoretically arise from antagonism of bradykinin B2 receptor. Caution when administering to patients with acute ischemic heart disease or unstable angina pectoris. In addition, caution should be observed in the administration of icatibant to patients in the weeks following a stroke. Although there is evidence to support a beneficial effect of B2 receptor blockade immediately following a stroke, there is a theoretical possibility that icatibant may attenuate the positive late phase neuroprotective effects of bradykinin ...
Angina pectoris is a term that describes chest pain caused by myocardial ischemia. It usually occurs on exertion and is relieved by rest. Angina generally is a symptom of coronary artery disease. In most severe cases, it occurs with minimal effort or at rest. Symptoms include anxiety, increased or irregular heart rate, paleness and cold…
Background and aim : Unstable angina, a common serious clinical entity, is associated with a high rate of complications. The aim of our study was to evaluate treatment costs of patients with uncomplicated and complicated follow-up in order to evaluate the economic consequences of new therapeutic strategies, like the introduction of GPIIb/Illa...
PCI is under siege. More and more evidence is accumulating that the " see stenosis and dilate" is bad practice. It looks like at the end of the day, PCI may only be genuinely indicated for patients with chest pains and even that we require unstable chest pains. The fact that optimal medical therapy is very good therapy for CAD, that the culprit lesion that are prognostic ally important are usually those less than 50% lesions, that PCI has not been shown to improve survival, all points to that PCI should be reserved for unstable angina, acute coronary syndromes and also MI ( STEMI / NSTEMI ). In fact there is even one meta-analysis which showed that even the presence of inducible ischemia is NOT a good indication for intervention ...
What is Angina Pectoris Angina pectoris is a term that describes chest pain caused by myocardial ischemia - a condition in which the amount of oxygen getting
The term angina pectoris refers to a feeling of pain or discomfort in the chest. Angina pectoris occurs when the heart muscle does not get enough blood and as a result, not enough oxygen, to function normally. Angina pectoris is usually caused by the hardening of the arteries. When plaques largely block the coronary
... , a term applied to a violent paroxysm of painful sensations in the chest, arising for the most part in connection with some form of heart disease. An attack of angina pectoris usually comes on with a sudden seizure of pain, felt at first over the region of the heart, but radiating through the chest in various directions, and frequently extending down the left arm. A feeling of constriction and of suffocation accompanies the pain, although there is seldom actual difficulty in breathing. When the attack comes on, as it often does, in the course of some bodily exertion, the sufferer is at once brought to rest, and during the continuance of the paroxysm expe-riences the most intense agony. The countenance becomes pale, the surface of the body cold, the pulse feeble, and death appears to be imminent, when suddenly the attack subsides, and complete relief is obtained. The duration of a paroxysm rarely exceeds two or three minutes, but it may last for a longer period. The attacks are ...
Angina, also called angina pectoris, is a recurring discomfort or pain in the chest that occurs when an inadequate supply of blood reaches the heart muscle. Angina is not a heart attack, though the symptoms are similar. It is a warning sign of a more serious condition, usually coronary artery disease. ...
Angina pectoris, also known as Angina, a symptoms of Ischemic heart disease, is defined as a condition of chest pain caused by poor blood flow through the blood vessels due to obstruction or spasm of the coronary arteries resulting of lack of blood that lead to lack of oxygen supply and waste removal. Preventions A. …. ...
... , also known as Angina, a symptoms of Ischemic heart disease, is defined as a condition of chest pain caused by poor blood flow through the blood vessels due to obstruction or spasm of the coronary arteries resulting of lack of blood that lead to lack of oxygen supply and waste removal. Types of …. ...
Angina is the medical term for chest pain caused by the heart. Learn more about whether your chest pain is angina, as well as how to handle angina symptoms.
The chest pain and discomfort common with angina may be described as pressure, squeezing, fullness or pain in the center of your chest. Some people with angina symptoms describe angina as feeling like a vise is squeezing their chest or feeling like a heavy weight has been placed on their chest. For others, it may feel like indigestion. ...
The thrombolysis in myocardial infarction (TIMI) risk score is a prognostic risk stratification system that categorises the risk of death and ischemic events in patients with unstable angina / NSTEMI and provides a basis for therapeutic decision ...
... Angina pain is not a heart attack. Angina pain means that some of the heart muscles have not been getting enough blood temporarily â€
2012 Writing Committee Members, Jneid H, Anderson JL, et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/Non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2012;126(7):875-910. PMID: 22800849 www.ncbi.nlm.nih.gov/pubmed/22800849. Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Circulation. 2010;122(24):2619-2633. PMID: 21060077 www.ncbi.nlm.nih.gov/pubmed/21060077. American College of Emergency Physicians; ...
Acute coronary syndrome continues to be a significant cause of morbidity and mortality in the United States. Family physicians need to identify and mitigate risk factors early, as well as recognize and respond to acute coronary syndrome events quickly in any clinical setting. Diagnosis can be made based on patient history, symptoms, electrocardiography findings, and cardiac biomarkers, which delineate between ST elevation myocardial infarction and non-ST elevation acute coronary syndrome. Rapid reperfusion with primary percutaneous coronary intervention is the goal with either clinical presentation. Coupled with appropriate medical management, percutaneous coronary intervention can improve short- and long-term outcomes following myocardial infarction. If percutaneous coronary intervention cannot be performed rapidly, patients with ST elevation myocardial infarction can be treated with fibrinolytic therapy. Fibrinolysis is not recommended in patients with non-ST elevation acute coronary syndrome;
Product Name: Prasugrel Tablets. Common Name: platelet inhibitor tablets. Strength: 60mg. Description: Prasugrel is used in combination with low dose aspirin to prevent thrombosis in patients with ACS, including unstable angina pectoris, non-ST elevation myocardial infarction (NSTEMI), and ST elevation myocardial infarction (STEMI), who are planned for treatment with PCI.. Prasugrel is a member of the thienopyridine class of ADP receptor inhibitors, like ticlopidine (trade name Ticlid) and clopidogrel (trade name Plavix).. Indications and Usage: Prasugrel is used with aspirin by patients with heart disease (recent heart attack, unstable angina) who undergo a certain heart procedure (angioplasty). This medication helps to prevent other serious heart/blood vessel problems (such as heart attacks, strokes, blood clots in stents). It works by blocking platelets from sticking together and prevents them from forming harmful blood clots. This "anti-platelet" effect helps to keep blood flowing smoothly ...
Apr 3, 2012 ... clopidogrel prices --- clopidogrel vs indocin --- stable angina asa plus clopidogrel ... Buy clopidogrel online at EXTRA LOW PRICES! including those with stable angina and found no advantage of clopidogrel plus aspirin compared to aspirin alone.17 Consistent with this, the current AHA/ACC ... Clopidogrel plus aspirin or aspirin alone in unstable angina. Shweta Gidwani and Richard Body ... He is haemodynamically stable. You treat him with oxygen, ... Apr 20, 2006 ... Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not ... been shown to reduce ischemic events in patients with unstable angina, ..... with stable cardiovascular disease or multiple cardiovascular risk factors. plus aspirin are the best options for people who have heart disease without symptoms or stable angina, while aspirin plus clopidogrel (Plavix) is the best option ... Stable angina - there is no evidence base to provide guidance; clopidogrel could be .... Clopidogrel plus omeprazole compared ...
... is a chapter in the book, Cardiovascular Medicine, containing the following 18 pages: Stable Coronary Artery Disease, Cocaine-Induced Coronary Vasospasm, Vasospastic Angina, Acute Coronary Syndrome, Acute Coronary Syndrome Immediate Management, Acute Coronary Syndrome Adjunctive Therapy, High Risk Acute Coronary Syndrome Management, Moderate Risk Acute Coronary Syndrome Management, Low Risk Acute Coronary Syndrome Management, Myocardial Infarction Stabilization, Post Myocardial Infarction Evaluation, Post Myocardial Infarction Medications, Cardiac Rehabilitation, Angina Pectoris, Angina Diagnosis, Unstable Angina, Unstable Angina Prognosis, Abnormal Coronary Arteries.
BACKGROUND: Measurement of high-sensitivity cardiac troponin levels is increasingly used in non-ST-elevation acute coronary syndrome (NSTE-ACS). However, studies investigating the distribution and prognostic implications of high-sensitivity troponin levels in men and women separately are currently lacking.. METHODS: Cardiac troponin I (cTnI) levels were determined using a high-sensitivity assay (Abbott Laboratories, Abbott Park, IL) in 1,677 male and 1,073 female NSTE-ACS patients participating in the GUSTO IV study. The prognostic associations of cTnI to outcome (30-day composite end point of recurrent myocardial infarction and 1-year mortality) were assessed in multivariable models, using cTnI both as a continuous variable and dichotomized at different sets of single and gender-specific 99th percentiles.. RESULTS: Median cTnI levels were 947 and 175 ng/L in men and women, respectively (P , .001). The adjusted odds ratios for cTnI (ln) were similar in men and women. The adjusted odds ratios for ...
Adult basic life support - Adult advanced life support - Universal treatment algorithm - Acute coronary syndrome (ACS) - ST elevation myocardial infarction (STEMI) - STEMI: diagnosis 1 - STEMI: diagnosis 2 - STEMI: general measures - STEMI: reperfusion therapy (thrombolysis) 1 - STEMI: thrombolysis 2 - STEMI: reperfusion by primary percutaneous coronary intervention (PCI) - Surgery for acute STEMI - STEMI: additional measures - Right ventricular (RV) infarction - STEMI: predischarge risk stratification - STEMI: complications - Ventricular septal defect post myocardial infarction (MI) - Acute mitral regurgitation post MI - Pseudoaneurysm and free wall rupture - Cocaine-induced MI - Ventricular tachyarrhythmia post MI - Atrial tachyarrhythmia post MI - Bradyarrhythmias and indications for pacing - Bradyarrhythmias post MI - Hypotension and shock post MI - Cardiogenic shock - Non-ST elevation myocardial infarction (NSTEMI)/unstable angina (UA) - NSTEMI/UA: diagnosis - NSTEMI/UA: risk stratification ...
Standard versus low-dose weight-adjusted heparin in patients treated with the platelet glycoprotein IIb/IIIa receptor antibody fragment Abciximab (c7E3 Fab) during percutaneous coronary revascularization Academic Article Article ...

Angina Unstable - DrugBankAngina Unstable - DrugBank

Also known as: Angina Pectoris, Unstable / Unstable Angina Pectoris / Unstable Angina (UA) / Angina, Unstable / Unstable Angina ... Accelerated angina / Intermediate coronary syndrome / Angina pectoris unstable / Angina at rest / Crescendo angina / Angina ... in the management of unstable angina (UA) and non-ST segment elevation myocardial infarction (NSTEMI); and in the management of ...
more infohttps://www.drugbank.ca/indications/DBCOND0035461

Unstable Angina Differential DiagnosesUnstable Angina Differential Diagnoses

Unstable angina belongs to the spectrum of clinical presentations referred to collectively as acute coronary syndromes (ACSs), ... encoded search term (Unstable%20Angina) and Unstable Angina What to Read Next on Medscape. Medscape Consult. ... Unstable Angina Differential Diagnoses. Updated: Dec 26, 2017 * Author: Walter Tan, MD, MS; Chief Editor: Eric H Yang, MD more ... Be aware that unstable angina can infrequently coexist or concurrently present with the following:. * Aortic dissection with ...
more infohttps://emedicine.medscape.com/article/159383-differential

Heart-Encyclopedia - unstable anginaHeart-Encyclopedia - unstable angina

unstable angina Unstable angina or sometimes referred to as acute coronary syndrome causes unexpected chest pain, and usually ...
more infohttp://www.heart.org/HEARTORG/Encyclopedia/Heart-Encyclopedia_UCM_445084_Encyclopedia.jsp?levelSelected=21&title=unstable%20angina

Unstable angina? - Heart Disease - MedHelpUnstable angina? - Heart Disease - MedHelp

Unstable angina?. My chest pains started up again about 2 months ago after 9 months without. I had one really bad attack, but ...
more infohttp://www.medhelp.org/posts/Heart-Disease/Unstable-angina/show/318197

Unstable Angina: Practice Essentials, Background, PathophysiologyUnstable Angina: Practice Essentials, Background, Pathophysiology

Unstable angina belongs to the spectrum of clinical presentations referred to collectively as acute coronary syndromes (ACSs), ... Unstable angina and NSTEMI: the early management of unstable angina and non-ST-segment-elevation myocardial infarction. London ... and death in unstable angina varies because of the broad clinical spectrum that is covered by the term unstable angina. The ... nearly 1 million hospitalized patients have a primary diagnosis of unstable angina. A similar number of unstable angina ...
more infohttps://emedicine.medscape.com/article/159383-overview

Unstable angina following anaphylaxis.Unstable angina following anaphylaxis.

The exact cause of her ongoing unstable angina was uncertain but may have reflected either ... A 55-year-old woman developed unstable angina following an episode of severe anaphylaxis which was treated with 0.5 mg ... Angina, Unstable / etiology*. Coronary Vasospasm / etiology. Epinephrine / administration & dosage*. Female. Food ... A 55-year-old woman developed unstable angina following an episode of severe anaphylaxis which was treated with 0.5 mg ...
more infohttp://www.biomedsearch.com/nih/Unstable-angina-following-anaphylaxis/19201942.html

Unstable anginaUnstable angina

... unstable angina patient,/b, and gave me medicines to be used for 6 months, which I am using continuously, but I am feeling ... after doing angiography my doctor diagnosed that I am an unstable angina patient and gave me medicines to be used for 6 months ... Home » Frequently asked Questions on Health » Unstable angina. Unstable angina. Answered by: Dr U Kaul , Director,. Director of ...
more infohttps://doctor.ndtv.com/faq/unstable-angina-1224

A Classification of Unstable Angina Revisited | CirculationA Classification of Unstable Angina Revisited | Circulation

... or unstable angina.. Angioscopic studies have revealed that the thrombus responsible for unstable angina is more commonly white ... secondary unstable angina. Most frequently, unstable angina is caused by coronary plaques that have undergone repeated phases ... correlate with the clinical severity of unstable angina.7 The plaque morphology in patients with higher grades of unstable ... "24 in unstable angina may therefore reflect the presence of an unstable plaque containing platelet-rich thrombus in the ...
more infohttp://circ.ahajournals.org/content/102/1/118.long

Heart Attack and Unstable Angina | CignaHeart Attack and Unstable Angina | Cigna

... and unstable angina. Discusses symptoms like chest pain or pressure. Explains MI and angina differences. Offers prevention tips ... Unstable angina. Unstable angina symptoms are similar to a heart attack. Call 911 or other emergency services immediately if ... What is angina, and why is unstable angina a concern?. Angina (say "ANN-juh-nuh" or "ann-JY-nuh") is a symptom of coronary ... Unstable angina means that your symptoms have changed from your typical pattern of stable angina. Your symptoms do not happen ...
more infohttps://www.cigna.com/healthwellness/hw/medical-topics/heart-attack-and-unstable-angina-tx2300

Unstable anginaUnstable angina

Any change from usual angina symptoms must be evaluated for presence of unstable angina or more severe ACS. *New-onset angina: ... which would be consistent with NSTEMI or unstable angina. Unstable angina can present in a variety of ways. Classically, acute ... Related topic: Angina pectoris. Codes. ICD10CM:. I20.0 - Unstable angina. SNOMEDCT:. 4557003 - Preinfarction syndrome. Look For ... Unstable angina. Subscriber Sign In VisualDx Mobile Feedback Select Language Share Enter a Symptom, Medication, or Diagnosis. ...
more infohttps://www.visualdx.com/visualdx/diagnosis/unstable+angina?moduleId=101&diagnosisId=55611

Unstable Angina: Long-Term CareUnstable Angina: Long-Term Care

The long-term treatment of angina depends on the severity of the coronary artery disease, the condition of ... ... Unstable Angina Long-Term Care. The long-term treatment of angina depends on the severity of the coronary artery disease, the ... PubMed Unstable Angina References *Abrams J. Clinical practice. Chronic stable angina. N Engl J Med. 2005 Jun 16;352(24):2524- ... Continue to Unstable Angina Diet Last Updated: Nov 7, 2007 References Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D ...
more infohttp://www.freemd.com/unstable-angina/treatment-long-term-care.htm

Heart Attack and Unstable AnginaHeart Attack and Unstable Angina

Explains MI and angina differences. Offers prevention tips. Covers diagnostic tests and treatment with medicines and surgery. ... and unstable angina. Discusses symptoms like chest pain or pressure. ... Unstable angina. Unstable angina symptoms are similar to a heart attack.. Call 911 or other emergency services immediately if ... What is angina, and why is unstable angina a concern?. Angina (say "ANN-juh-nuh" or "ann-JY-nuh") is a symptom of coronary ...
more infohttps://www.chathamhospital.org/ch/health-library/document-viewer/?id=tx2300

Heart Attack and Unstable AnginaHeart Attack and Unstable Angina

Explains MI and angina differences. Offers prevention tips. Covers diagnostic tests and treatment with medicines and surgery. ... and unstable angina. Discusses symptoms like chest pain or pressure. ... Unstable angina. Unstable angina symptoms are similar to a heart attack. Call 911 or other emergency services immediately if ... What is angina, and why is unstable angina a concern?. Angina (say "ANN-juh-nuh" or "ann-JY-nuh") is a symptom of coronary ...
more infohttps://www.concordhospital.org/wellness-resources/health-library/healthwise-document-viewer/?id=tx2300

Management of unstable angina soon after myocardial infarction.Management of unstable angina soon after myocardial infarction.

The recurrence of angina soon after myocardial infarction is not uncommon and represents areas of viable myocardium at risk ... Angina Pectoris / therapy*. Angina, Unstable / physiopathology, therapy*. Angioplasty, Balloon. Anticoagulants / therapeutic ... The recurrence of angina soon after myocardial infarction is not uncommon and represents areas of viable myocardium at risk ...
more infohttp://www.biomedsearch.com/nih/Management-unstable-angina-soon-after/2898267.html

Angioplasty for Heart Attack and Unstable AnginaAngioplasty for Heart Attack and Unstable Angina

... Treatment Overview. Angioplasty gets blood flowing back to the heart. It ... Only small areas of the heart are at risk, and you do not have disabling angina symptoms. ... Have frequent or severe angina that is not responding to medicine and lifestyle changes. ...
more infohttps://www.cardiosmart.org/Healthwise/tx43/03/tx4303

Uptake | Unstable angina and NSTEMI: early management | Guidance and guidelines | NICEUptake | Unstable angina and NSTEMI: early management | Guidance and guidelines | NICE

Unstable angina and NSTEMI: early management [CG94]. Measuring the use of this guidance. Recommendation: 1.5.1. Offer coronary ... Perform angiography as soon as possible for patients who are clinically unstable or at high ischaemic risk. ...
more infohttps://www.nice.org.uk/guidance/CG94/uptake

Unstable Angina Pectoris « Conditions « AdaUnstable Angina Pectoris « Conditions « Ada

... also known as unstable angina pectoris, is a medical emergency with sudden chest pain or tightness that worsens over a short ... Unstable Angina Pectoris. What is unstable angina pectoris?. Unstable angina, also known as unstable angina pectoris, is a ... Treatment of unstable angina involves short-term measures to reduce pain and long-term measures to reduce the risk of a heart ... The symptoms of unstable angina often come on quickly, and may have no predictable trigger. Some people experience symptoms ...
more infohttps://ada.com/conditions/unstable-angina-pectoris/

Effect of stopping smoking after unstable angina and myocardial infarction | The BMJEffect of stopping smoking after unstable angina and myocardial infarction | The BMJ

Effect of stopping smoking after unstable angina and myocardial infarction Br Med J (Clin Res Ed) 1984; 288 :146 ... Effect of stopping smoking after unstable angina and myocardial infarction. Br Med J (Clin Res Ed) 1984; 288 doi: https://doi. ...
more infohttp://www.bmj.com/content/288/6411/146.1

Heart Attack and Unstable Angina - WellSpan Health LibraryHeart Attack and Unstable Angina - WellSpan Health Library

... and unstable angina. Discusses symptoms like chest pain or pressure. Explains MI and angina differences. Offers prevention tips ... Unstable angina. Unstable angina symptoms are similar to a heart attack. Call 911 or other emergency services immediately if ... What is angina, and why is unstable angina a concern?. Angina (say "ANN-juh-nuh" or "ann-JY-nuh") is a symptom of coronary ... Unstable angina means that your symptoms have changed from your typical pattern of stable angina. Your symptoms do not happen ...
more infohttps://www.wellspan.org/health-library/Document.aspx?id=tx2300

Unstable Angina: Causes, symptoms, treatment, and preventionUnstable Angina: Causes, symptoms, treatment, and prevention

... unstable, and variant. This article will focus primarily on unstable angina, which is when plaque in the blood vessels either ... Unstable angina is not relieved by your common medications-rather, it requires emergency treatment ... In unstable angina, pain and symptoms may appear even while resting.. Unstable angina is a sign that arteries are narrowing and ... Treating unstable angina. Treatment for unstable angina depends on the severity of the condition. For starters, you may be put ...
more infohttps://www.belmarrahealth.com/unstable-angina-common-cause-heart-attack-causes-symptoms-treatment-prevention/

Drug-Eluting Balloon in Stable and Unstable Angina - Full Text View - ClinicalTrials.govDrug-Eluting Balloon in Stable and Unstable Angina - Full Text View - ClinicalTrials.gov

Drug-Eluting Balloon in Stable and Unstable Angina (DEBUT). The safety and scientific validity of this study is the ... Angina, Unstable. Heart Diseases. Cardiovascular Diseases. Arteriosclerosis. Arterial Occlusive Diseases. Vascular Diseases. ... Drug-Eluting Balloon in Stable and Unstable Angina: a Randomized Controlled Non-inferiority Trial. ... Stable angina or dyspnea and a coronary narrowing causing myocardial ischemia detected in the angiogram. Ischemia is documented ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01781546?term=heart+attack&lup_s=01%2F24%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14

Drug-Eluting Balloon in Stable and Unstable Angina - Full Text View - ClinicalTrials.govDrug-Eluting Balloon in Stable and Unstable Angina - Full Text View - ClinicalTrials.gov

Drug-Eluting Balloon in Stable and Unstable Angina (DEBUT). The safety and scientific validity of this study is the ... Angina, Unstable. Heart Diseases. Cardiovascular Diseases. Arteriosclerosis. Arterial Occlusive Diseases. Vascular Diseases. ... Drug-Eluting Balloon in Stable and Unstable Angina: a Randomized Controlled Non-inferiority Trial. ... Stable angina or dyspnea and a coronary narrowing causing myocardial ischemia detected in the angiogram. Ischemia is documented ...
more infohttps://clinicaltrials.gov/show/NCT01781546

Late Results Following Emergency Saphenous Vein Bypass Grafting For Unstable Angina | CirculationLate Results Following Emergency Saphenous Vein Bypass Grafting For Unstable Angina | Circulation

Late Results Following Emergency Saphenous Vein Bypass Grafting For Unstable Angina. LAWRENCE I. BONCHEK, SHAHBUDIN H. ... Late Results Following Emergency Saphenous Vein Bypass Grafting For Unstable Angina. LAWRENCE I. BONCHEK, SHAHBUDIN H. ... Late Results Following Emergency Saphenous Vein Bypass Grafting For Unstable Angina. LAWRENCE I. BONCHEK, SHAHBUDIN H. ... after extended follow-up indicate that emergency saphenous vein bypass grafting is an effective therapy for unstable angina. ...
more infohttp://circ.ahajournals.org/content/50/5/972

Unstable angina and NSTEMI: early management - NICE guideline | RCP LondonUnstable angina and NSTEMI: early management - NICE guideline | RCP London

This guideline covers treatments for people aged 18 and over with unstable angina (recurring chest pain) or a type of heart ... What is angina and NSTEMI? The term acute coronary syndromes encompasses a range of conditions from unstable angina to ST- ... Unstable angina and NSTEMI: early management - NICE guideline. Produced by:. NICE guidelines developed at NGC ... Management of unstable angina and NSTEMI would be enhanced if the relative place of these investigations was better understood ...
more infohttps://www.rcplondon.ac.uk/guidelines-policy/unstable-angina-and-nstemi-early-management-nice-guideline

Unstable angina | Multimedia Encyclopedia | Health Information | St. Lukes HospitalUnstable angina | Multimedia Encyclopedia | Health Information | St. Luke's Hospital

Unstable angina. Accelerating angina; New-onset angina; Angina - unstable; Progressive angina; CAD - unstable angina; Coronary ... unstable angina; Heart disease - unstable angina; Chest pain - unstable angina ... Unstable angina is chest pain that is sudden and often gets worse over a short period of time. You may be developing unstable ... Rare causes of angina are: Angina. Angina is a type of chest discomfort or pain due to poor blood flow through the blood ...
more infohttps://www.stlukes-stl.com/health-content/health-ency-multimedia/1/000201.htm
  • Unstable angina is characterized by at least one of the following: Occurs at rest or minimal exertion and usually lasts more than 20 minutes (if nitroglycerin is not administered) Being severe (at least Canadian Cardiovascular Society Classification 3) and of new onset (i.e. within 1 month) Occurs with a crescendo pattern (brought on by less activity, more severe, more prolonged or increased frequency than previously). (wikipedia.org)
  • The patient's history and diagnostic testing are generally more sensitive and specific for unstable angina than the physical examination, which may be unremarkable. (medscape.com)
  • Aside from a physical examination, your doctor will run other tests to better diagnose unstable angina. (belmarrahealth.com)
  • Long-term treatment for unstable angina often involves medications to thin the blood, to control blood pressure and to reduce cholesterol levels. (ada.com)
  • The fibrous cap is unstable and can rupture, leading to embolism of the plaque contents with distal obstruction or exposure of the pro-thrombotic core, leading to localized thrombosis. (visualdx.com)
  • This article will focus primarily on unstable angina, which is when plaque in the blood vessels either ruptures or forms a blood clot, suddenly reducing or blocking the blood flow. (belmarrahealth.com)
  • 8 Rupprecht et al 9 reported that the incidence of the angiographic evidence of complex lesions and/or thrombosis rose progressively with higher unstable angina classes. (ahajournals.org)
  • Despite advances in medicine and improving survival rates after myocardial infarction (MI), the incidence of angina is expected to rise despite various prevention measures currently in place. (belmarrahealth.com)