Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.Angina, Unstable: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.Angina Pectoris, Variant: A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.Angina, Stable: Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Microvascular Angina: ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Coronary Vasospasm: Spasm of the large- or medium-sized coronary arteries.Oxyfedrine: A drug used in the treatment of angina pectoris, heart failure, conduction defects, and myocardial infarction. It is a partial agonist at beta adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Isosorbide Dinitrate: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.Thimerosal: An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.Coronary Vessels: The veins and arteries of the HEART.Amino Alcohols: Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Chest Pain: Pressure, burning, or numbness in the chest.Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.Physical Exertion: Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.Atherectomy, Coronary: Percutaneous transluminal procedure for removing atheromatous plaque from the coronary arteries. Both directional (for removing focal atheromas) and rotational (for removing concentric atheromatous plaque) atherectomy devices have been used.Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.Acetanilides: Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Myocardial Revascularization: The restoration of blood supply to the myocardium. (From Dorland, 28th ed)Cineangiography: Motion pictures of the passage of contrast medium through blood vessels.Practolol: A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Angiocardiography: Radiography of the heart and great vessels after injection of a contrast medium.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Oxprenolol: A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.Phonocardiography: Graphic registration of the heart sounds picked up as vibrations and transformed by a piezoelectric crystal microphone into a varying electrical output according to the stresses imposed by the sound waves. The electrical output is amplified by a stethograph amplifier and recorded by a device incorporated into the electrocardiograph or by a multichannel recording machine.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Nicorandil: A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.Electrocardiography, Ambulatory: Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Genetic Variation: Genotypic differences observed among individuals in a population.Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Sympatholytics: Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Plaque, Atherosclerotic: Lesions formed within the walls of ARTERIES.Ludwig's Angina: Severe cellulitis of the submaxillary space with secondary involvement of the sublingual and submental space. It usually results from infection in the lower molar area or from a penetrating injury to the mouth floor. (From Dorland, 27th ed)Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.PropiophenonesCalcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.Ultrasonography, Interventional: The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Coronary Stenosis: Narrowing or constriction of a coronary artery.Placebos: Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.Spinal Cord Stimulation: Application of electric current to the spine for treatment of a variety of conditions involving innervation from the spinal cord.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Propanolamines: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Fibrinolysis: The natural enzymatic dissolution of FIBRIN.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Laser Therapy: The use of photothermal effects of LASERS to coagulate, incise, vaporize, resect, dissect, or resurface tissue.Recurrence: The return of a sign, symptom, or disease after a remission.Troponin T: One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Electric Stimulation Therapy: Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.Collateral Circulation: Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.Heart: The hollow, muscular organ that maintains the circulation of the blood.Photoinitiators, Dental: Chemical compound used to initiate polymerization of dental resins by the use of DENTAL CURING LIGHTS. It absorbs UV light and undergoes decomposition into free radicals that initiate polymerization process of the resins in the mix. Each photoinitiator has optimum emission spectrum and intensity for proper curing of dental materials.Neopterin: A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin.Exercise Tolerance: The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)Trimetazidine: A vasodilator used in angina of effort or ischemic heart disease.Diltiazem: A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.Eye Manifestations: Ocular disorders attendant upon non-ocular disease or injury.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Diagnostic Techniques, Cardiovascular: Methods and procedures for the diagnosis of diseases or dysfunction of the cardiovascular system or its organs or demonstration of their physiological processes.Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.Prenylamine: A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Indoramin: An alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Death, Sudden: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Colic: A clinical syndrome with intermittent abdominal pain characterized by sudden onset and cessation that is commonly seen in infants. It is usually associated with obstruction of the INTESTINES; of the CYSTIC DUCT; or of the URINARY TRACT.Pentaerythritol Tetranitrate: A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025)Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Platelet Aggregation Inhibitors: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.PropylaminesDipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Vectorcardiography: Recording of the moment-to-moment electromotive forces of the heart on a plane of the body surface delineated as a vector function of time.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Creatine Kinase: A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.Tomography, Emission-Computed, Single-Photon: A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Tomography, Spiral Computed: Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Syndrome: A characteristic symptom complex.Heart Ventricles: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.Northern IrelandDrug Tolerance: Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Hemostasis: The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.JapanPostcholecystectomy Syndrome: Abdominal symptoms after removal of the GALLBLADDER. The common postoperative symptoms are often the same as those present before the operation, such as COLIC, bloating, NAUSEA, and VOMITING. There is pain on palpation of the right upper quadrant and sometimes JAUNDICE. The term is often used, inaccurately, to describe such postoperative symptoms not due to gallbladder removal.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Investigation of the most effective provocation test for patients with coronary spastic angina: usefulness of accelerated exercise following hyperventilation. (1/135)

This study sought to compare the clinical usefulness of the hyperventilation plus cold stress test or the hyperventilation combined with accelerated exercise test with other single tests in patients with coronary spastic angina. The study examined 24 patients (23 men, mean age 66 years) with angiographically confirmed coronary spastic angina and less than 50% stenosis. Moreover, none had spontaneous ST segment elevation before the study. Under no medication for at least 24 h prior, 4 procedures were performed from 09.00 h to 11.00 h: (i) a hyperventilation test for 5 min (HV(5)); (ii) HV(5) combined with a cold stress test for the last 2 min (HV(5)+CS(2)); (iii) a treadmill exercise test based on Bruce's protocol (TM(3)); and (iv) a treadmill exercise test accelerated at 1 min intervals according to Bruce's protocol immediately after HV(5) (HV(5)+TM(1)). The rate of appearance of chest pain and ischemia-induced ECG changes due to HV(5)+TM(1) were significantly higher than the other 3 tests. HV(5)+CS(2) was not superior to HV(5) alone. The incidence of provoked ST segment elevation due to HV(5)+TM(1) was higher than with the other 3 procedures. Thus, in patients with coronary spastic angina, no spontaneous ST segment elevation and near normal coronary arteries, HV(5)+CS(2) was no more useful than HV(5) alone. It is recommended that the newly designed HV(5)+TM(1) combination test be used for documenting evidence of ischemia in patients with coronary spastic angina, low disease activity and near normal coronary arteries.  (+info)

Consumption of vitamin E in coronary circulation in patients with variant angina. (2/135)

OBJECTIVES: The plasma status of vitamin E has been suggested to be linked to the activity of coronary artery spasm. This study was designed to determine whether vitamin E is actually consumed in the coronary circulation in patients with active variant angina having repetitive spasm-induced transient myocardial ischemia and reperfusion. METHODS: Blood samples were obtained simultaneously from the aortic root, coronary sinus and right atrium in 12 patients with variant angina due to spasm of the left coronary artery, nine patients with stable effort angina and nine control subjects. Plasma vitamin E (alpha- and gamma-tocopherol) concentrations were determined by use of high-performance liquid chromatography and plasma lipid peroxides were measured as thiobarbituric acid-reactive substances (TBARS). RESULTS: At baseline, both plasma alpha- (p < 0.01) and gamma- (p < 0.05) tocopherol levels were significantly lower in the coronary sinus (5.50 +/- 0.50 and 0.55 +/- 0.07 mg/l, mean +/- SEM) than in the aortic root (6.63 +/- 0.57 and 0.63 +/- 0.08 mg/l) and also in the right atrium (6.44 +/- 0.61 and 0.63 +/- 0.09 mg/l) in the variant angina group. The TBARS level was significantly (p < 0.05) higher in the coronary sinus than in the aortic in this group. In contrast, these levels were not significantly different between the samples from the coronary sinus and the aortic root or the right atrium in the control group and also in the stable effort angina group. The coronary sinus-aortic difference in plasma vitamin E levels in the variant angina group was not significantly altered after left coronary artery spasm induced by intracoronary injection of acetylcholine. Also, the plasma vitamin E levels in the aortic root, coronary sinus and right atrium all remained unchanged in the stable effort angina group after pacing-induced angina and in the control group after intracoronary administration of acetylcholine. CONCLUSIONS: Transcardiac reduction in plasma vitamin E concentrations concomitant with lipid peroxide formation was demonstrated in patients with active variant angina, suggesting actual consumption of this major endogenous antioxidant. Oxidative stress and vitamin E exhaustion may be involved in the pathogenesis of coronary artery spasm.  (+info)

Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients. (3/135)

Japanese investigators have provided a substantial contribution in the understanding of coronary vasomotor reactivity. On occasions, their findings have been at variance with those undertaken on caucasian patients, raising speculation that vasomotor differences between races may exist. In a comparative review of the published literature, we evaluated the vasoreactive differences among Japanese and caucasian patients with variant angina or myocardial infarction. In variant angina, Japanese patients appear to have diffusely hyperreactive coronary arteries compared with caucasian people, manifested by their segmental rather than focal spasm, hyperreactive nonspastic vessels and multivessel spasm. These differences may reflect the increased basal tone among Japanese variant angina patients and may relate to controversial differences in endothelial nitric oxide production or autonomic nervous system activity. Provocative vasomotor studies of Japanese patients with a recent myocardial infarction report a higher incidence of inducible spasm than caucasian studies, an observation recently supported by a controlled study. Furthermore, the hyperreactivity was diffuse, occurring in both non-infarct- and infarct-related vessels. These observations support the existence of racial coronary vasomotor reactivity differences but require confirmation in further prospectively conducted studies.  (+info)

Alterations of autonomic nervous activity in recurrence of variant angina. (4/135)

OBJECTIVE: To investigate whether autonomic nervous activity is involved in the recurrence of spontaneous coronary spasm in variant angina. DESIGN: Retrospective analysis. SETTING: Cardiology department of a university hospital. PATIENTS: 18 patients with variant angina were divided into single attack group (SA; nine patients) and multiple attack group (MA; nine patients) according to the frequency of ischaemic episodes with ST segment elevation during 24 hour Holter monitoring. METHODS: Heart rate variability indices were calculated using MemCalc method, which is a combination of the maximum entropy method for spectral analysis and the non-linear least squares method for fitting analysis, at 30 second intervals for 30 second periods, from 40 minutes before the attack to 30 minutes after the attack. High frequency (HF; 0.04-0.15 Hz) was defined as a marker of parasympathetic activity, and the ratio of low frequency (LF; 0.15-0.40 Hz) to high frequency (LF/HF) as an indicator of sympathetic activity. The averaged value during the 40 to 30 minute period before an attack was defined as the baseline. RESULTS: Compared with baseline, the HF component decreased in both groups at two minutes before the attack (p < 0.01), and the LF/HF ratio decreased at three minutes before the attack (p < 0.01). The baseline LF/HF was lower in the MA group than in the SA group (p < 0. 01). CONCLUSIONS: A reduction of sympathetic activity may play a key role in determining the recurrence of transient ischaemic events caused by spontaneous coronary spasm in patients with variant angina.  (+info)

Vasospastic angina likely related to cisplatin-containing chemotherapy and thoracic irradiation for lung cancer. (5/135)

Vasospastic angina is rarely observed during cancer treatment. The present report describes two males with lung cancer, aged 73 and 61, who developed vasospastic angina during combination treatment of cisplatin-containing chemotherapy and thoracic irradiation. As both patients have smoked and their ages are typical for patients with coronary artery disease, such events may be incidental. However, oncologists should be aware of the possible development of myocardial ischemia during or following administration of antineoplastic agents, especially in elderly patients with pre-existing coronary risk factors or a history of thoracic radiotherapy.  (+info)

Prognostic significance of the pattern of multivessel spasm in patients with variant angina. (6/135)

Multivessel spasm in variant angina is believed to be a major prognostic factor. Three patterns of multivessel spasm have been detected: (1) spasm at different sites on different occasions (migratory spasm); (2) spasm sequentially affecting 2 different sites (sequential spasm); and (3) simultaneous spasm at more than 1 site (simultaneous spasm). The present study investigated the prognosis based on this factor for variant angina without fixed coronary stenosis and examined the influence of multivessel spasm on cardiac events. Twenty-six patients were diagnosed as having variant angina without fixed coronary stenosis using 12-lead 24-h ECG recording system and coronary cineangiography. These patients were followed up prospectively for 57.1+/-7.6 months. Of the 26 patients 13 had single-vessel spasm, 6 had migratory multivessel spasm angina, and 7 showed sequential and/or simultaneous multivessel spasm angina. The survival free of serious cardiac events and of all cardiac events was significantly lower for patients with sequential and/or simultaneous multivessel spasm than for those with migratory multivessel spasm (p<0.05, p<0.05), whereas for patients with migratory multivessel spasm the difference comparison with single-vessel spasm did not attain statistical significance (p = ns, p = ns). The results of this study suggest that there seems to be a high-risk subgroup (i.e., sequential and/or simultaneous multivessel spasm) among patients with variant angina.  (+info)

Plasma endothelin-1 elevation associated with alcohol-induced variant angina. (7/135)

Vasospastic angina as a result of alcohol ingestion has been reported, but the mechanism of alcohol-induced coronary artery spasm is presently unknown. This report presents 2 cases of alcohol-induced variant angina (VA) with elevated levels of plasma endothelin-1 after alcohol ingestion. In case 1, the plasma endothelin-1 concentration was 3.15 pg/ml before drinking (normal <2.30 pg/ml) and increased to 4.09 pg/ml when measured 5 h after alcohol ingestion. After 2 months of abstinence, the plasma endothelin-1 concentration was 2.88 pg/ml and 6 months after abstinence, it decreased to 2.03 pg/ml (normal range). In case 2, the plasma endothelin-1 concentration was 2.44 pg/ml before drinking and increased to 4.36 pg/ml when measured 5 h after alcohol ingestion. After 2 months of abstinence, the plasma endothelin-1 concentration was 3.04 pg/ml and 6 months after abstinence, it decreased to 2.09 pg/ml (normal range). These 2 cases suggest that a relationship may exist between alcohol-induced VA and elevation in the plasma endothelin-1 concentration after alcohol ingestion.  (+info)

Beware of the heart: the multiple picture of cardiac involvement in myositis. (8/135)

A 42-yr-old woman with dermatomyositis had two myocardial infarctions, episodes of acute chest pain and an acute lung oedema. These events were initially misinterpreted as atherosclerotic ischaemic heart disease accompanying the autoimmune disease. The lack of improvement of cardiac symptoms with anti-ischaemic and immunosuppressive drugs indicated other mechanisms. Intracoronary drug provocation as well as myocardial biopsy revealed a coincidence of small-vessel disease and vasospastic angina as a cause for the severe cardiac symptoms. After initiating therapy with high doses of calcium channel blockers, marked improvement of cardiac symptoms occurred. In the pathogenesis of cardiac involvement in dermatomyositis, two different mechanisms should be considered: inflammatory processes due to dermatomyositis and vasoconstriction caused by an impaired regulation of vascular tone, such as abnormal vessel reactivity or disturbed neuropeptide release. Signs of this generalized vasopathy are Raynaud's phenomenon, Prinzmetal's angina and small-vessel disease, which can coincide. In patients with severe cardiac symptoms and autoimmune diseases, Prinzmetal's angina should be excluded by intracoronary drug provocation using acetylcholine.  (+info)

*List of examples of Stigler's law

A variant form of angina pectoris. Preliminary report. Am Heart J 1959; 27:375. Grattan-Guinness, Ivor (1997): The Rainbow of ... Prinzmetal angina: also known as variant angina, referring to angina (chest pain) caused by vasospasm of the coronary arteries ... Electrocardiographic study during a paroxysm of angina pectoris. Am Heart J 1933; 9:259. Prinzmetal, M, Kennamer, R, Merliss, R ... Electrocardiographic changes during brief attacks of angina pectoris. Lancet 1931; 1:15. Brow, GR, Holman, DV. ...

*Prinzmetal's angina

"Angina pectoris I. A variant form of angina pectoris". The American Journal of Medicine. 27 (3): 375-88. doi:10.1016/0002-9343( ... "Prinzmetal's Angina, Variant Angina and Angina Inversa". American Heart Association. Retrieved 2015-06-20. Yoo, Sang-Yong; Kim ... also known as variant angina, vasospastic angina (VSA), angina inversa, or coronary vessel spasm) is a syndrome typically ... It was described as "A variant form of angina pectoris" in 1959 by the American cardiologist Myron Prinzmetal (1908-1987). ...

*List of MeSH codes (C23)

... angina pectoris MeSH C23.888.646.215.500.150 --- angina, unstable MeSH C23.888.646.215.500.150.150 --- angina pectoris, variant ...

*List of MeSH codes (C14)

... angina pectoris MeSH C14.280.647.250.125.150 --- angina, unstable MeSH C14.280.647.250.125.150.150 --- angina pectoris, variant ... angina pectoris MeSH C14.907.553.470.250.125.130 --- angina pectoris, variant MeSH C14.907.553.470.250.125.150 --- angina, ... angina pectoris, variant MeSH C14.280.647.500 --- myocardial infarction MeSH C14.280.647.500.375 --- myocardial stunning MeSH ... angina pectoris, variant MeSH C14.907.553.470.500 --- myocardial infarction MeSH C14.907.553.470.500.375 --- myocardial ...

*Propranolol

Hypertension Angina pectoris (with the exception of variant angina) Tachyarrhythmia Myocardial infarction Tachycardia (and ... It is used to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks ...

*Levine's sign

... myocardial infarction and angina pectoris). A variant of this sign which uses the entire palm instead of the clinched fist over ...

*Robert Ira Lewy

"Comparison of Plasma Concentrations of Thromboxane B-2 and Prinzmetal's Variant Angina and Classical Angina Pectoris". Clinical ... "Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina". Prostaglandines and Medicine. 2 (4): 243 ...

*Nicholas Kounis

Kounis syndrome (allergic angina and allergic myocardial infarction). Angina Pectoris. Etiology, Pathogenesis and Treatment. ... Elevation of plasma histamine concentration in the coronary circulation in patients with variant angina. Am J Cardiol 1996;77: ... Tryptase levels are elevated during spontaneous ischemic episodes in unstable angina but not after ergonovine test in variant ... "Kounis syndrome (allergic angina and allergic myocardial infarction): A natural paradigm?" Kounis NG. International Journal of ...

*Antianginal

An antianginal is any drug used in the treatment of angina pectoris, a symptom of ischaemic heart disease. Drugs used are ... They are contraindicated in variant angina and can precipitate heart failure. They are also contraindicated in severe ... and most effectively in the treatment of variant angina (directly preventing coronary artery vasospasm). They are not used in ... Nifedipine is more a potent vasodilator and more effective in angina. It is in the class of dihydropyridines and does not ...

*William Richards (minister)

He died at Lynn on 13 September 1818 of angina pectoris, and was buried alogside his wife in the General Baptist Burial Ground ... and by topographical and statistical information, with accounts of the religious houses formerly in Lynn, and of the progress ...

*C-reactive protein

... the study group in this case consisted of patients who had been diagnosed with unstable angina pectoris; whether elevated CRP ... a 2008 study compared people with various genetic CRP variants. Those with a high CRP due to genetic variation had no increased ... can be used for clinical decision-making without adjustment for CRP gene variants. acute phase erythrocyte sedimentation rate C ...

*Ayurveda

During this period, treatments were also prescribed for complex ailments, including angina pectoris, diabetes, hypertension, ... Hoernle identified the scribe of the medical portions of the manuscript to be a native of India using a northern variant of the ...

*Diltiazem

Variant angina - it is effective owing to its direct effects on coronary dilation. Unstable angina (preinfarction, crescendo ... angina pectoris, and some types of arrhythmia. It relaxes the smooth muscles in the walls of arteries, which opens (dilates) ... The drug is indicated for angina: Stable angina (exercise-induced) - diltiazem increases coronary blood flow and decreases ... "Long-acting diltiazem HCL for the chronotherapeutic treatment of hypertension and chronic stable angina pectoris". Expert ...

*Angina

Unstable angina (UA) (also "crescendo angina"; this is a form of acute coronary syndrome) is defined as angina pectoris that ... A variant form of angina-Prinzmetal's angina-occurs in patients with normal coronary arteries or insignificant atherosclerosis ... Worsening angina attacks, sudden-onset angina at rest, and angina lasting more than 15 minutes are symptoms of unstable angina ... Angina, also known as angina pectoris, is chest pain or pressure, usually due to not enough blood flow to the heart muscle. ...

*1896 in art

... is created 1st Baron Leighton in the peerage of the United Kingdom one day before his death in London of angina pectoris. ... English topographical artist, lithographer and photographer (born 1814) April 16 - Viktor Oskar Tilgner, Austrian sculptor ( ...

*Migraine treatment

1966). "The prophylactic value of propranolol in angina pectoris". Am J Cardiol. 18 (3): 370-83. doi:10.1016/0002-9149(66)90056 ... 1985). Frequencies of hemoglobin variants: thalassemia, the glucose-6-phosphate dehydrogenase deficiency, G6PD variants, and ... propranalol's effectiveness in headache treatment was a chance finding in patients receiving the drug for angina (chest pain ...

*Charles Darwin

In 1882 he was diagnosed with what was called "angina pectoris" which then meant coronary thrombosis and disease of the heart. ... The last word was the only variant of "evolved" in the first five editions of the book. "Evolutionism" at that time was ... and a Malthusian Nature selecting from chance variants so that "every part of newly acquired structure is fully practical and ...

*Framingham Heart Study

... leading to angina pectoris, myocardial infarction (MI), and coronary death, along with other important studies about smoking, e ... Apr 2006). "A common genetic variant is associated with adult and childhood obesity". Science. 312 (5771): 279-83. doi:10.1126/ ... and revealed a genetic variant associated with obesity. The researchers were able to replicate this particular result in four ...

*Pindolol

... is used for hypertension in the United States, Canada, and Europe, and also for angina pectoris outside the United ... Jasper JR, Kosaka A, To ZP, Chang DJ, Eglen RM (1997). "Cloning, expression and pharmacology of a truncated splice variant of ... Pindolol has modest beta-adrenergic agonist activity and is therefore used with caution in angina pectoris. Pindolol is a non- ... is a beta blocker which is used in the treatment of hypertension and angina pectoris. It is also an antagonist of the serotonin ...

*Toothache

The most critical nondental source is the radiation of angina pectoris into the lower teeth and the potential need for urgent ... A variant of the periodontal abscess is the gingival abscess, which is limited to the gingival margin, has a quicker onset, and ... Other non-dental causes of toothache include myofascial pain (muscle pain) and angina pectoris (which classically refers pain ... or angina pectoris, which can cause pain in the lower teeth. Toothache is the most common type of orofacial pain and, when ...

*Coronary artery disease

Cardiac syndrome X is chest pain (angina pectoris) and chest discomfort in people who do not show signs of blockages in the ... Other genome-wide studies have identified a firm risk variant on chromosome 9 (9p21.3). However, these and other loci are found ... Angina that changes in intensity, character or frequency is termed unstable. Unstable angina may precede myocardial infarction ... refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death. ...

*Ouabain

... in angina pectoris and myocardial infarction despite its poor and variable absorption. The positive properties of ouabain ... and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies. Sci Transl ...

*List of Indian inventions and discoveries

Angina pectoris:The condition was named "hritshoola" in ancient India and was described by Sushruta (6th century BC). Low-cost ... A variant of this game, called Luodo, made its way to England during the British Raj. Snakes and ladders: Vaikunta pali Snakes ... Chess spread throughout the world and many variants of the game soon began taking shape. This game was introduced to the Near ...

*Heart

... angina pectoris), to minimise heart muscle damage when an artery is completely occluded (myocardial infarction), or to prevent ... They may range from the relatively minor (e.g. patent foramen ovale, arguably a variant of normal) to serious life-threatening ... Severe narrowings may cause chest pain (angina) or breathlessness during exercise or even at rest. The thin covering of an ... Medications to improve angina symptoms include nitroglycerin, beta blockers, and calcium channel blockers, while preventative ...

*Andrew Lang

He died of angina pectoris at the Tor-na-Coille Hotel in Banchory, Banchory, survived by his wife. He was buried in the ... Andrew Lang, Introduction to Marian Roalfe Cox's Cinderella: Three Hundred and Forty-Five Variants of Cinderella, Catskin and, ...

*Marfan syndrome

... pectus excavatum) or protrusion (pectus carinatum) of the sternum, abnormal joint flexibility, a high-arched palate with ... A heart murmur, abnormal reading on an ECG, or symptoms of angina can indicate further investigation. The signs of ... Marfanoid-progeroid-lipodystrophy syndrome (MPL), also referred to as Marfan lipodystrophy syndrome (MFLS), is a variant of ... Pectus carinatum deformity = 2 (pectus excavatum or chest asymmetry = 1) Hindfoot deformity = 2 (plain pes planus = 1) Dural ...
We made continuous electrocardiographic recordings on magnetic tape during 15 episodes of ischemia in five patients with variant angina to determine the characteristics of the QRS changes. Orthogonal leads were used and the electrocardiograms were analyzed visually and by digital computer. Changes were quantified by subtracting baseline electrocardiograms from those obtained during ischemia. Large changes in the QRS occurred during ischemia but the waveform quickly returned to baseline when the episode subsided. In all patients there was prolongation of the QRS duration and an increase in QRS voltage during the terminal 40 msec of the waveform in the lead(s) showing the most marked ST displacement. The increase in the terminal QRS could be represented by a vector directed toward the ischemic zone. In a given patient the amplitude of ST displacement varied between episodes, presumably because of variation in the intensity of ischemia, but the QRS changes were directionally similar in each ...
A 24-year-old male student had three myocardial infarctions, one prior to and two following the angiographic documentation of normal coronary arteries. A spontaneous episode of variant angina prompted repeat coronary angiography, during which intravenous ergonovine caused spasm of the left anterior descending coronary artery, transient ST-segment elevation, and ischemic chest pain; the previously normal right coronary artery was found to be occluded proximally. This constellation of clinical and angiographic findings suggests that coronary spasm can cause acute myocardial infarction as well as variant angina. ...
Coronary artery spasm is an important pathogenetic mechanism in some forms of myocardial ischemic disease. Factors that may be important in the genesis of spasm include the autonomic nervous system, prostaglandins, endoperoxides, thromboxanes, and the calcium availability to the contractile apparatus. Spasm results in myocardial ischemia with attendant chest pain and electrocardiographic and hemodynamic changes; it is the primary pathogenetic mechanism in Prinzmetals variant angina and has been found in association with classic angina pectoris and acute myocardial infarction. Diagnosis of coronary artery spasm is firmly made only by coronary angiography. Treatment includes the use of both short- and long-acting nitrates and the slow-channel blocking agents such as verapamil, nifedipine, and perhexiline. ...
Patient has a history or clinical evidence of ischemic heart disease (e.g., angina pectoris of any type, history of myocardial infarction or documented silent ischemia) or symptoms or findings consistent with ischemic heart disease, coronary artery vasospasm (including Prinzmetals variant angina), or other significant underlying cardiovascular disease. Patient has uncontrolled hypertension. Patient has either demonstrated hypersensitivity to or experienced a serious adverse event in response to Rizatriptan or any of its inactive ingredients ...
Felodipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetals variant angina. Felodipine is similar to other peripheral vasodilators. Felodipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes blocking the calcium channels. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload ...
Amlodipine, a calcium-channel blocker, is used alone or with benazepril, an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetals variant angina. Amlodipine is similar to the peripheral vasodilator nifedipine and other members of the dihydropyridine class ...
Learn more about Variant Angina: Heart Spasms at Redmond Regional Medical Center Whenever most people think of chest pain, they associate it with a heart...
Vasospastic angina is presented by myocardial ischemia with spasm of coronary artery accompanying chest pain or discomfort. The precise mechanisms have not been established, but a reduction in NO (nitric oxide) production, an imbalance between endothelium-derived relaxing and contracting factors,or an injury of endothelium have been suggested.. Impaired FMD(flow mediated endothelium-dependent vasodilation) in the brachial artery was demonstrated in vasospastic angina,and improvement of endothelial dysfunction with treatment of statin is documented in several studies.. So, we expect that statin treatment for vasospastic angina provide additional therapeutic effects via improvement of endothelial dysfunction. ...
Her finder du det sidste nye om Prinzmetal Variant Angina og det Kardiologiske Syndrom X, samt et debatforum hvor patienter har mulighed for at komme i kontakt med andre i samme situation.
We conclude that 1) plasma levels of FPA, BTG, and PF4 were increased in patients with variant angina as compared with those with stable exertional angina; 2) there was a significant circadian variation in the plasma levels of FPA in parallel with that of the frequency of the attacks with the peak level occurring from midnight to early morning in patients with variant angina; and 3) elevated levels of plasma FPA are the result and not the cause of coronary spasm ...
It is believed that the vasoconstriction caused by thromboxanes plays a role in Prinzmetals angina. Omega-3 fatty acids are metabolized to produce higher levels of TxA,3 which is relatively less potent than TxA2 and PGI3; therefore, there is a balance shift toward inhibition of vasoconstriction and platelet aggregation. It is believed that this shift in balance lowers the incidence of myocardial infarction (heart attack) and stroke. Vasoconstriction and, perhaps, various proinflammatory effects exerted by TxA on tissue microvasculature, is probable reason why the TxA is pathogenic in various diseases, such as ischemia-reperfusion injury.,[2] hepatic inflammatory processes,[3] acute hepatotoxicity [4] etc. TxB2, a stable degradation product of TxA2, plays a role in acute hepatoxicity induced by acetaminophen.[5][6]. ...
Chest pain that results when blood flow through the coronary arteries is insufficient to meet the oxygen needs of the heart. Often simply called angina. It is marked by pressure, squeezing, or general discomfort in the heart, breast, and neck, and can also spread to the back, shoulders, jaw, arm, and fingers. People experiencing angina may also feel light-headed and have an abnormally fast or irregular heartbeat. See Stable angina, Unstable angina, and Variant angina.. ...
Variant angina was described in 1959 by Prinzmetal and colleagues1 and later recognised as a consequence of coronary spasm in normal coronary arteries.2 Coronary spasm is a multifactorial process (endothelial dysfunction, hypersensitivity to vasoconstrictor stimuli, hypercontractility of vascular smooth muscle). Coronary artery spasm may also have a broader role in patients with arteriosclerotic coronary artery disease.3 Intracoronary infusion of acetylcholine has been shown to induce severe coronary spasm in patients with variant angina.4 The standard treatment of patients with variant angina is to eliminate vasoconstrictive factors (cigarette smoking, hyperventilation, and cocaine use) and administer vasodilating drugs. Despite extensive treatment with vasodilators (nitrates, calcium antagonist, nicorandil, and nebivolol), our patient complained of daily angina and thus we sought an alternative mode of clinical management.. Brachytherapy is a recently proposed treatment for in-stent restenosis ...
Cardiac syndrome X is angina (chest pain) with signs associated with decreased blood flow to heart tissue but with normal coronary arteries. Cardiac syndrome X is sometimes referred to as microvascular angina when there are findings of microvascular dysfunction. Some studies have found increased risk of other vasospastic disorders in cardiac syndrome X patients, such as migraine and Raynauds phenomenon. It is treated with beta-blockers, such as metoprolol, and usually carries a favorable prognosis. This is a distinct diagnosis from Prinzmetals angina. While there is no formal definition for cardiac syndrome X, the general consensus is that it entails all of the following: Angina: This usually does not cause dysfunction on echocardiogram and can last longer than that of heart disease. Abnormal cardiac stress test: ST changes are typically similar to those of coronary artery disease, and the opposite of those of Prinzmetals angina. Myocardial perfusion imaging can be abnormal in 30% of ...
Symptoms are often very similar to pain associated with a more typical heart attack (development of a blockage in a heart artery). Symptoms often occur at rest, and at night. This is different than typical chest pain associated with heart artery blockages which is more typically experience during exertion.. ...
Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, which can present with a wide spectrum of clinical scenario. We report the cases of two patients diagnosed with vasospastic angina, with one of which presenting with sudden cardiac arrest, while the other presenting with a relatively benign syncope. But both of them have J waves formation on ECG during active ischemia. The diagnosis and management of vasospastic angina, as well as the proposed clinical significance of J waves during coronary spasm are discussed. ...
There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of SUMAVEL® DosePro®. SUMAVEL® DosePro® may cause coronary artery vasospasm (Prinzmetals angina). These types of reactions have occurred in some patients without known CAD. For triptan-naïve patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluation, consider administrating the first SUMAVEL® DosePro® dose in a medically-supervised setting and performing an electrocardiogram (ECG) immediately following SUMAVEL® DosePro® administration. For such patients, consider periodic cardiovascular evaluation in intermittent long-term users of SUMAVEL® DosePro®. Life-threatening arrhythmias have been reported within a few hours following the administration of 5-HT1 agonists. Discontinue SUMAVEL® DosePro® if these disturbances occur. Sensations of tightness, pain, pressure, and heaviness have been ...
Do not take Coreg if you are allergic to Coreg components.. Do not take Coreg if youre pregnant or you plan to have a baby, or you are a nursing mother.. Be careful with Coreg if you have a history of asthma, emphysema, thyroid disorder, pheochromocytoma, myasthenia gravis, low blood pressure, liver, kidney or heart disease diabetes, hyperthyroidism, depression, Prinzmetals angina, bronchitis.. Be careful using Coreg if you take monoamine oxidase inhibitors (tranylcypromine (such as Parnate), isocarboxazid (such as Marplan), selegiline (such as Zelapar, Eldepryl, Emsam), phenelzine (such as Nardil)); verapamil (such as Calan,Verelan, Covera-HS); paroxetine (such as Paxil); cimetidine (such as Tagamet); rifampin (such as Rifadin, Rimactane); clonidine (such as Catapres), cyclosporine (such as Sandimmune, Neoral); digoxin (such as Lanoxin, Lanoxicaps); quinidine; diltiazem (such as Tiazac, Cardizem); fluoxetine (such as Prozac); epinephrine (such as Epipen); oral diabetes medicines and insulin; ...
Exercise induced ST elevation in patients with previous myocardial infarction may simply indicate left ventricular wall asynergy. ST segment elevation without prior myocardial infarction is a rare condition and is commonly associated with critical coronary artery stenosis.1 Temporary ST segment elevation associated with chest pain is the hallmark of variant (Prinzmetal) angina, and is a consequence of severe coronary spasm. In a way that is not yet fully understood, exercise can induce coronary spasm in patients with variant angina, as demonstrated in small groups of patients subjected to supine bicycle exercise on the cardiac catheterisation table.2DSE is widely performed as a useful diagnostic tool in patients with known or suspected coronary artery disease. Through its inotropic and chronotropic effects, dobutamine increases the myocardial oxygen demand and may induce ischaemia and segmental wall motion abnormality in the presence of significant coronary artery disease. Myocardial ischaemia ...
In 1959 Myron Prinzmetal first described variant angina. Without the aid of selective coronary angiography he attributed the syndrome to the "temporary occlusion of a large diseased artery with a narrow lumen due to a normal increase in the tonus of the vessel wall.". A 66 year old woman who had been smoking 15 cigarettes each day for 50 years and who had a long history of Raynauds syndrome presented with an episode of severe chest pain associated with pronounced ST elevation in the inferior and lateral leads (left). She was enrolled in a thrombolytic trial that involved the performance of early coronary angiography. Ninety minutes after receiving 100 mg of tissue plasminogen activator the ST segments were still elevated. Coronary angiography of the right coronary artery showed a discrete 90% stenosis that resolved following 200 μg of intracoronary nitroglycerin (top). An ECG recorded 30 minutes later demonstrated complete resolution of the ST segments (bottom). There was no subsequent enzyme ...
There are three types of angina - stable, unstable and prinzmetals. Stable angina is the most common and symptoms usually last for a few minutes before they subside, often with the help of nitroglycerine tablets.. With unstable angina the symptoms can be more severe and not so predictable. The attacks often last much longer and can occur even at times of rest. An unstable attack can be a precursor to a heart attack and thus it is taken more seriously than stable angina. Medical attention should be sought immediately at the first sign of unstable angina.. Prinzmetals, is defined as angina that occurs when the patient is at rest, rather than the result of physical exercise. Dr James Pierce Ph.D., relates that hes identified the cause of this angina. He says that it generally occurs at certain times of the day, in the early morning and late afternoon.(1) These are, as it happens, the times of day when Mg is at its lowest ebb in the body.. Dr Pierce estimates that some 50% of sudden heart attacks ...
In patients with angina and nonobstructive coronary-artery disease, coexistence of epicardial coronary spasm and increased microvascular resistance (IMR) is associated with worse outcomes, according to Japanese researchers.
Angina pectoris,Types as stable,unstable and even Microvascular,Signs and Symptoms,Risk factors,Diagnosis,Life Style Modification and Prinzmetal Angina
Angina itself is not a disease, rather a symptom of an underlying heart problem such as coronary heart disease, the most common heart disease.
Prinzmetal angina olarak da bilinen vazospastik angina, bir ok fakt r n tetikleyebilece i bir damar a r duyarl l olarak d n lmektedir. T bbi tedaviye yan t s kl kla iyidir, ancak her be hastadan birinde diren li semptomlar g r lmektedir. Nadiren vazospazma ba l l mc l aritmiler g r lebilmektedir ve bu hastalarda prognoz daha k t d r. Burada, kalsiyum kanal blokeri ve nitrat tedavisine ra men semptomlar devam eden diren li bir vazospastik anginal olguyu sunduk. Hasta, hemodinamik bozuklu a yol a an ve tekrarlayan kardiyoversiyonlara diren li y ksek h zl ventrik ler ta ikardi ile ba vurdu. T bbi tedavisine ek olarak, koronerlerdeki belirgin vazospastik segmentlere stent yerle tirilerek tedavi edildi. Ayr ca, vazospazm kesin bir tedavisi olmayan yayg n bir vask ler hastal k oldu undan, ventrik l aritmilerine kar ikincil korunma ama l implante edilebilir defibrilat r yerle tirildi ...
The "Baseline" and "Classical" controllers use a classic cascaded-loop architecture with three inner P-only loops to control the angular rates p,q,r, and three outer PI loops to control the angular positions phi,alpha,beta. The six proportional gains and three integral gains are all scheduled as a function of alpha and beta. The "Baseline" variant contains the baseline design featured in docid:aeroblks_ug.f4-50264. Parts 2 and 3 of this series use the "Classical" variant to walk through the tuning process. The active variant is controlled by the workspace variable CTYPE. Set its value to 2 to activate the "Classical" variant of the controller.. ...
Collins, Hugh (2011) Constructive dismissal and the West Lothian question: Aberdeen City Council v McNeill. Industrial Law Journal, 40 (4). pp. 439-450. ISSN 0305-9332 ...
1. Armstrong PW. Stable ischemic syndromes. In: Topol E. Textbook of Cardiovascular Medicine. Philadelphia: Lippincott Raven Publishers 1998. 2. Chatterjee T, Juelke PD, Thum P et al. Successful brachytherapy of coronary vasospasm. Heart 2003; 89(9): 25. 3. Cheng TO. Clinical implication of the hyperventilation test in the diagnosis of coronary artery spasm. Am J Cardiol 1997; 80: 1647. 4. Gersh BJ, Braunwald E, Bonow BO. Chronic coronary artery disease. In: Braunwald E. Heart Disease. A textbook of cardiovascular medicine. 6th ed. Philadelphia: WB Saunders 2001. 5. Halawa B, Salomon P. Activity of transmembrane calcium transport and levels of endothelin-1 in patients with variant angina. Pol Arch Med Wewn 2000; 104(2): 447-453. 6. Hirano Y, Ozasa Y, Yamamoto T et al. Hyperventilation and cold pressor stress echocardiography for noninvasive diagnosis of coronary artery spasm. J Am Soc Echocardiogr 2001; 14(6): 626-633. 7. Hirano Y, Ozasa Y, Yamamoto T et al. Diagnosis of vasospastic angina by ...
The occurrence of vasospasm can be reduced by preventing the occurrence of atherosclerosis. This can be done in several ways, the most important being lifestyle modifications-decreasing low-density lipoprotein (LDL), quitting smoking, physical activity, and control for other risk factors including diabetes, obesity, and hypertension. Pharmacological therapies include hypolipidemic agents, thrombolytics and anticoagulants. Pharmacological options for reducing the severity and occurrence of ischemic episodes include the organic nitrates classified as having long acting (i.e. isosorbide dinitrate) and short acting (i.e. nitroglycerin) durations of action. These drugs work by increasing nitric oxide levels in the blood and inducing coronary vasodilation which will allow for more coronary blood flow due to a decreased coronary resistance, allowing for increased oxygen supply to the vital organs (myocardium). The nitric oxide increase in the blood resulting from these drugs also causes dilation of ...
Introduction Oral capecitabine is an oral prodrug of 5-fluorouracil that has been integrated into the management of multiple cancer types because of the convenience of administration and its efficacy...
Angina - MedHelps Angina Center for Information, Symptoms, Resources, Treatments and Tools for Angina. Find Angina information, treatments for Angina and Angina symptoms.
Rx unstable angina: Immediate aggressive treatment to prevent final heart attack = angina is the precursor to mi. Angina is when heart oxygenation not able to provide support to the degree of daily activities for the person. A lot of mi heart attack) without even a warning sign of angina. 50% of mi result in immediate death. No time to waste. Sx vary a lot from person to person. Sudden stomach pain sx can be angina. ...Read more See 1 more doctor answer ...
What is Angina Pectoris Angina pectoris is a term that describes chest pain caused by myocardial ischemia - a condition in which the amount of oxygen getting
The term angina pectoris refers to a feeling of pain or discomfort in the chest. Angina pectoris occurs when the heart muscle does not get enough blood and as a result, not enough oxygen, to function normally. Angina pectoris is usually caused by the hardening of the arteries. When plaques largely block the coronary
... , a term applied to a violent paroxysm of painful sensations in the chest, arising for the most part in connection with some form of heart disease. An attack of angina pectoris usually comes on with a sudden seizure of pain, felt at first over the region of the heart, but radiating through the chest in various directions, and frequently extending down the left arm. A feeling of constriction and of suffocation accompanies the pain, although there is seldom actual difficulty in breathing. When the attack comes on, as it often does, in the course of some bodily exertion, the sufferer is at once brought to rest, and during the continuance of the paroxysm expe-riences the most intense agony. The countenance becomes pale, the surface of the body cold, the pulse feeble, and death appears to be imminent, when suddenly the attack subsides, and complete relief is obtained. The duration of a paroxysm rarely exceeds two or three minutes, but it may last for a longer period. The attacks are ...
Angina pectoris, also known as Angina, a symptoms of Ischemic heart disease, is defined as a condition of chest pain caused by poor blood flow through the blood vessels due to obstruction or spasm of the coronary arteries resulting of lack of blood that lead to lack of oxygen supply and waste removal. Preventions A. …. ...
... , also known as Angina, a symptoms of Ischemic heart disease, is defined as a condition of chest pain caused by poor blood flow through the blood vessels due to obstruction or spasm of the coronary arteries resulting of lack of blood that lead to lack of oxygen supply and waste removal. Types of …. ...
Another name for Unstable Angina is Angina. Facts about angina: * Heart disease is the leading cause of death in the United States. * Over two million ...
Cathy suffers from unstable angina pectoris and has had one pre-heart attack. Hi! I am Cathy and 68 years old. Independence is the most important thing
Angina is the medical term for chest pain caused by the heart. Learn more about whether your chest pain is angina, as well as how to handle angina symptoms.
Study Flashcards On Medsurg: Cardiovascular: Angina Pectoris at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
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Angina is not a heart attack, but it does increase your risk of having a heart attack. Know the ways using which you can cope with Angina.
I saw a cardiologist a few months ago. She said my symptoms didnt sound like angina because angina pain is usually the same each time it happens. Does anyone have any views on her comment about ang...
Angina can be a painful chronic condition but with angina medications & treatments those with angina can reduce pain. Get more info & browse our Rx discounts.
You may have no problems when you are at rest; however, if you are doing some exercise or something that requires the heart to pump harder, it can cause a cramp-like central chest pain which is called... ...
Learn more about Angina at TriStar Southern Hills DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
'n Pasient met 'n siektegeskiedenis wat angina pectoris aandui, het by elektrokardiografiese ondersoek die bevinding van 'n positiewe inspanningstoets getoon.
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Angina pectoris is the medical term for chest pain caused by a lack of blood and/or oxygen in the heart muscle. The term comes from the Greek word "ankhon" meaning "strangling" and the Latin word "pectus" meaning "chest". This is most likely due to the fact that someone suffering from this condition describes the pain of an attack as a squeezing sensation, a tightness in the chest, or a feeling of pressure.. In addition to chest discomfort, pain from angina pectoris may also be felt in the upper abdomen, neck, jaw, back, or shoulders. The pain can be accompanied by sweating, breathlessness, or nausea. Angina pectoris attacks usually last for 1 to 5 minutes; pain lasting only a few seconds is normally not angina pectoris. Angina pectoris attacks that worsen as the attack progresses, angina pectoris that occurs suddenly while you are at rest, and angina pectoris lasting longer than 15 minutes are all considered signs of unstable angina. Unstable angina is an indication that an individual has a ...
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The global angina pectoris drugs market is expected to be valued at USD 10.6 Billion by 2022, as per a new report by Grand View Research, Inc. The global angina pectoris market is collectively driven by demand for disease-modifying and targeted treatments, increased expenditure on healthcare and availability of effective treatment methods across the emerging markets.. (Logo: http://photos.prnewswire.com/prnh/20160524/371361LOGO ) Additionally, the rising prevalence and incidence of angina pectoris is anticipated to fuel the market growth. Chronic stable angina pectoris has a prevalence of 2.0-4.0% in developed markets such as the U.S., the U.K., Germany, France, Italy, Spain and Japan. The prevalence of angina pectoris rises sharply with age in both genders, ranging from 2.0- 5.0% in men aged 45-54 to 10.0-20.0% in men aged 65-74, and from 0.1-1.0% in women aged 45-54 to 10.0-15.0% in women aged 65-74. The disease symptoms can be managed by following a healthy lifestyle.. Browse full research ...
Dr. Stern responded: Yes it can in some. If you are prone to coronary artery spasm, then emotional |a href="/topics/stress" track_data="{
Get information, facts, and pictures about angina pectoris at Encyclopedia.com. Make research projects and school reports about angina pectoris easy with credible articles from our FREE, online encyclopedia and dictionary.
An episode of angina does not indicate that a heart attack is occurring, or that a heart attack is about to occur. Angina does indicate, however, that coronary heart disease is present and that some part of the heart is not receiving an adequate blood supply. Persons with angina have an increased risk of heart attack.. A person who has angina should note the patterns of his or her symptoms--what causes the chest pain, what it feels like, how long episodes usually last, and whether medication relieves the pain. Call for medical assistance if the angina episode symptoms change sharply.. ...
Angina pectoris is a term that describes chest pain caused by myocardial ischemia. It usually occurs on exertion and is relieved by rest. Angina generally is a symptom of coronary artery disease. In most severe cases, it occurs with minimal effort or at rest. Symptoms include anxiety, increased or irregular heart rate, paleness and cold…
Is Angina Pectoris a common side effect of Valsacor? View Angina Pectoris Valsacor side effect risks. Male, 72 years of age, weighting 158.7 lb, was diagnosed with benign prostatic hyperplasia, hypertension and took Valsacor .
Stable vs Unstable Angina Stable angina and unstable angina are two clinical entities in cardiology caused by reduced blood supply to the heart muscle.
Angina pectoris is the result of myocardial ischemia caused by an imbalance between myocardial blood supply and oxygen demand. Angina is a common presenting symptom (typically, chest pain) among patients with coronary artery disease.
GlobalData, the industry analysis specialist, has released its new report, Unstable Angina Therapeutics - Pipeline Assessment and Market Forecast to 2018. The report is an essential source of information and analysis on the global Unstable Angina Therapeutics market. The report identifies the key trends shaping and driving the global Unstable Angina Therapeutics market. The report also provides insights on the prevalent competitive landscape and the emerging players expected to significantly alter the market positioning of the current market leaders. Most importantly, the report provides valuable insights on the pipeline products within the global Unstable Angina Therapeutics sector. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts.
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During Angine pectoris, patient suffers from actute chest pain accompanied by breathlessness, sweating and nausea. Beta blockers, Nitro-vasodilators, Calcium Channel Blockers, asprin combinations are used for the treatment of angina pectoris.
Another name for Unstable Angina is Angina. The long-term treatment of angina depends on the severity of the coronary artery disease, the condition of ...
But there is a disorder of the breast marked with strong and peculiar symptoms, considerable for the kind of danger belonging to it, and not extremely rare, which deserves to be mentioned more at length. The seat of it and the sense of strangling and anxiety with which it is attended, may make it not improperly be called angina pectoris. Those who are afflicted with it, are seized while they are walking (more especially if it be uphill, and soon after eating) with a painful and most disagreeable sensation in the breast, which seems as if it would extinguish life if it were to increase or to continue; but the moment they stand still, all this uneasiness vanishes. In all other respects, the patients are, at the beginning of this disorder, perfectly well, and in particular have no shortness of breath, from which it is totally different. The pain is sometimes situated in the upper part, sometimes in the middle, sometimes in the bottom of the os. sterni, and often more inclined to the left than to ...
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The chest pain and discomfort common with angina may be described as pressure, squeezing, fullness or pain in the center of your chest. Some people with angina symptoms describe angina as feeling like a vise is squeezing their chest or feeling like a heavy weight has been placed on their chest. For others, it may feel like indigestion. ...
Angina refers to a chest pain that occurs when blood flow to the heart muscle is reduced. What does angina feel like? How do you know if you are experiencing this coronary artery disease symptom?
Background and aim : Unstable angina, a common serious clinical entity, is associated with a high rate of complications. The aim of our study was to evaluate treatment costs of patients with uncomplicated and complicated follow-up in order to evaluate the economic consequences of new therapeutic strategies, like the introduction of GPIIb/Illa...
... is temporary moderate to severe pain or pressure in the chest. Sometimes the pain extends to the left shoulder and down the left arm or to the throat, ...
... occurs when the heart is not getting enough oxygen-rich blood for a short time. This section of the eMedTV archives provides an in-depth look at the three types of angina, their symptoms, causes, and treatment options.
This is named for obvious reasons. The J point is elevated and, along with the T wave, and it looks like a tombstone. In an anterior MI that shows "tombstoning," there is frequently 4 to 6 millimeter of ST segment elevation. Do not confuse the ST segment elevation with the T wave. Look specifically where the ST segment is - waaaaay up from the baseline. Recall that the J point is where we need to measure the elevation from baseline, and the baseline is always the TP segment (between the T wave and the P wave).. ...
While a number of causes of true cardiac pain may be eliminated by improvement in any loss of compensation by improvement of the heart tone by more or less recovery from myocardial or endocardial inflammation and by the w.
Cardiology news, research and treatment articles offering cardiology healthcare professionals cardiology information and resources to keep them informed.
One danger is that we might seek to build up our bank account of righteousness through our giving. A strategy to combat this is to give frivolously. Someone might say, "Why did you give them money? Theyre just going to buy alcohol." But this frivolous giving is basically a way of saying, "To hell with the world and worldly success." Ultimately, its a way of tearing up dollar bills in the middle of the street.". ...
Learn more about Angina at TriStar Centennial Parthenon Pavilion DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Angina at Largo Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Looking for online definition of angina pectoris variant in the Medical Dictionary? angina pectoris variant explanation free. What is angina pectoris variant? Meaning of angina pectoris variant medical term. What does angina pectoris variant mean?
Looking for Ergonovine? Find out information about Ergonovine. a uterine stimulant; one of the most common ergot alkaloids. Ergonovine is used in obstetrics in cases of uterine bleeding. It is administered orally in... Explanation of Ergonovine
Define angina pectoris. angina pectoris synonyms, angina pectoris pronunciation, angina pectoris translation, English dictionary definition of angina pectoris. n. Severe paroxysmal pain in the chest associated with an insufficient supply of blood to the heart. n. a sensation of crushing pressure in the chest, usu....
Angina is the medical term used to describe the sharp, crushing pain that one experiences when there is a limited supply of blood to the heart causing the latter to be deprived of much needed oxygen. In most cases, the angina can be felt in the chest and can radiate towards the limbs. Most medical professionals do not treat angina as a disease on its own. Instead, it is seen as a sign or a symptom of an even more serious heart condition such as Coronary Heart Disease, or what most people refer to as CHD. In a CHD, there is a build up of plaque along the walls of the arteries. This causes narrowing of the path where the oxygen-rich blood can pass through.. Although most people see angina as only one kind, there is actually four major types of angina that a person might suffer from. Of these four, it is the stable angina that is considered to be the most common. In a stable angina, the onset is pretty much predictable. For one, a stable angina typically takes place only after too much physical ...
2018 Medmovie.com. All rights reserved. Medmovie.com creates and licenses medical illustrations and animations for educational use. Our goal is to increase your understanding of medical terminology and help communication between patients, caregiver and healthcare professionals. The content in the Media Library is for your information and education purposes only. The Media Library is not a substitute for professional medical advice, diagnosis or treatment for specific medical conditions. ...
Summary of Facts and Submissions. I. European patent No 0 278 776 with the title Methods and deoxyribonucleic acid for the preparation of tissue factor protein was granted with 26 claims based on European patent application No.88 301 190.0, claiming priority from US 13743 of 12 February 1987, from US 35409 of 7 April 1987 and from US 152698 of 5 February 1988.. Granted claims 1, 11 and 20 read as follows:. 1. A polynucleotide as defined in Figure 2, or a variant thereof, encoding a biologically active tissue factor protein or a biologically active variant or fragment of the said tissue factor protein wherein at least one amino acid has been selectively inserted, deleted or substituted.. 11. A biologically active tissue factor protein capable of being encoded by a polynucleotide as defined in claim 1 or a biologically active variant or fragment of said tissue factor protein which either lacks glycosylation, or has non-mammalian glycosylation.. 20. A nucleotide sequence encoding a ...
... pectoris is a Latin phrase that means “Strangling in the chest†. Patients often describe angina as a squeezing, suffocating, or burning sensation in the chest. However, an episode of angina is not a heart attack.
... pectoris is a Latin phrase that means “Strangling in the chest†. Patients often describe angina as a squeezing, suffocating, or burning sensation in the chest. However, an episode of angina is not a heart attack.
Easy to read patient leaflet for Ergonovine. Includes indications, proper use, special instructions, precautions, and possible side effects.
Angina, also called angina pectoris, is a recurring discomfort or pain in the chest that occurs when an inadequate supply of blood reaches the heart muscle. Angina is not a heart attack, though the symptoms are similar. It is a warning sign of a more serious condition, usually coronary artery disease. ...
Jen Woodall wrote: , I strongly believe , that should be recognized in whatever way each person chooses. I always , acknowledge the date (well, close to it--cant always remember the exact , date) of my dx in some way. I know my diagnosis date EXACTLY, and I know exactly when my BGs started to go up, and I know when they went kablooie rapidly. I started to have problems in the summer of 1991; my BGs went kablooie starting on July 28, 1992, and I was officially diagnosed on Aug. 17, 1992 after landing in the hospital with a coronary artery spasm. Then they went back down again, and I was able to maintain on diet and exercise until the summer of 1993; in Sept. 1993, I went to the doc, and my BGs were once again rising rapidly, so she tried increasing doses and different sulfonylureas to no effect. I finally went on insulin on May 12, 1994, and THATs the date I celebrate! Like insulin gave me my life back, and I think THATs worth celebrating -- during my time on diet and orals, I was consistently ...
Angina pectoris (heart attack). Cardiology: Diagnostic in Herne, Germany ✈. Prices on BookingHealth.com - booking treatment online!
Reviews and ratings for taztia xt when used in the treatment of angina pectoris prophylaxis. Share your experience with this medication by writing a review.
What is Angina? From the Latin angere, which means to choke, angina refers to pain and intense pressure in the chest. The sensations are produced by inadequate blood flow to the muscles of the heart, leaving them starving for oxygen. Angina is one o
[114 Pages Report] Check for Discount on Stable Angina Global Clinical Trials Review, H2, 2016 report by GlobalData. Stable Angina Global Clinical Trials Review, H2, 2016 Summary GlobalData...
Covers causes of heart attack (myocardial infarction) and unstable angina. Discusses symptoms like chest pain or pressure. Explains MI and angina differences. Offers prevention tips. Covers diagnostic tests and treatment with medicines and surgery.
Covers causes of heart attack (myocardial infarction) and unstable angina. Discusses symptoms like chest pain or pressure. Explains MI and angina differences. Offers prevention tips. Covers diagnostic tests and treatment with medicines and surgery.
Recently active Chest Pain (Angina) forums and community discussion threads. Post your question or story about Chest Pain (Angina) and connect with others who have experience with the same medications. No registration is required and your identity remains anonymous.
View messages from patients providing insights into their medical experiences with Angina - Share Your Experience. Share in the message dialogue to help others and address questions on symptoms, diagnosis, and treatments, from MedicineNets doctors.
View messages from patients providing insights into their medical experiences with Angina - Types. Share in the message dialogue to help others and address questions on symptoms, diagnosis, and treatments, from MedicineNets doctors.
Generic Drugs prescribed for Angina Pectoris (Anti-Anginals) like Tiazac, Verapamil, Dilacor are now added to InternationalDrugMart.com
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Despite the high incidence of angina pectoris (Despite the high incidence of angina pectoris † and its varied causes, a relatively large number of patients, after most careful routine physical examination, roentgenological investigations, and routine electrocardiographic studies (including chest leads) yield findings within normal or nearly normal limits. In such cases the diagnosis must be made upon the description of symptoms obtained from the patient. According to Burnett1 one-third of the patients, and according to the experience of Paul D. White2 20 to 25 per cent of the patients having angina pectoris fall within this group.) and its varied causes, a relatively large number of patients, after most careful routine physical examination, roentgenological investigations, and routine electrocardiographic studies (including chest leads) yield findings within normal or nearly normal limits. In such cases the diagnosis must be made upon the description of symptoms obtained from the patient. ...
In recent years there has been growing interest in coronary artery disease in women, particularly with regard to gender differences. We know from the Framingham study that women develop coronary disease at an older age and often have different presenting manifestations. For example, women are more likely to have chest pain as their initial symptom (1). Several studies have investigated gender differences with respect to outcome after myocardial infarction but relatively few have examined outcomes after diagnosis of angina. The study by Orencia and colleagues compares outcomes in men and women with angina pectoris. The diagnosis of angina was based on symptoms alone and did not require objective evidence of ischemia. Details regarding the character of chest pain or the frequency of typical compared with atypical pain were not provided. The finding of a more favorable prognosis in women with an initial diagnosis of angina is encouraging but may be misleading. As the authors acknowledge, angina is ...
Native coronary artery spasm after coronary artery bypass grafting (CABG) is scarce. It frequently causes disastrous circulatory collapse. We report a 72-yr-old male, who experienced native coronary artery spasm and grafted artery spasm following CAB
Background and Purpose: Coronary artery disease in moyamoya disease (MMD) have been described sporadically in several case reports. The purpose of this study is to determine the prevalence and characteristics of coronary artery disease in patients with MMD.. Methods: From August 1991 to December 2012, 446 patients diagnosed with adult MMD at our hospital. Baseline characteristics and prevalence of coronary artery disease were reviewed based on medical records and laboratory findings. The findings of conventional coronary angiography and/or coronary computed tomography were also reviewed for the presence and appearance of coronary artery lesion.. Results: - Of 446 patients with adult MMD, 21 patients were found to have coronary artery disease. Ten patients were treated with coronary artery bypass graft (n=4) or percutaneous coronary intervention (n=6) for unstable angina or myocardial infarction. Eleven were treated with medication for stable angina (n=6) and variant angina with mild degree of ...

Inflammation and Microvascular Dysfunction in Cardiac Syndrome X Patients Without Conventional Risk Factors for Coronary Artery...Inflammation and Microvascular Dysfunction in Cardiac Syndrome X Patients Without Conventional Risk Factors for Coronary Artery...

Patients with angina at rest and those with Prinzmetals variant angina were not included in the study, and those with diabetes ... 2004) Angina pectoris and normal coronary arteries: cardiac syndrome X. Heart 90:457-463. ... Recently, it has become apparent that a large proportion of patients with typical angina pectoris have normal coronary ... 1997) Both endothelium-dependent and endothelium-independent function is impaired in patients with angina pectoris and normal ...
more infohttp://imaging.onlinejacc.org/content/6/6/660

The QRS complex during transient myocardial ischemia: studies in patients with variant angina pectoris and in a canine...The QRS complex during transient myocardial ischemia: studies in patients with variant angina pectoris and in a canine...

The QRS complex during transient myocardial ischemia: studies in patients with variant angina pectoris and in a canine ... The QRS complex during transient myocardial ischemia: studies in patients with variant angina pectoris and in a canine ... The QRS complex during transient myocardial ischemia: studies in patients with variant angina pectoris and in a canine ... The QRS complex during transient myocardial ischemia: studies in patients with variant angina pectoris and in a canine ...
more infohttp://circ.ahajournals.org/content/71/5/901

Angina Pectoris - AHealthyMe - Blue Cross Blue Shield of MassachusettsAngina Pectoris - AHealthyMe - Blue Cross Blue Shield of Massachusetts

... or simply angina - is chest pain or discomfort that keeps coming back. It happens when some part of your heart does not get ... Variant angina pectoris. This is also called Prinzmetals angina. It is rare. It occurs almost only at rest, not after exercise ... Angina Pectoris. What is angina pectoris?. Angina pectoris is chest pain or discomfort that occurs when a part of your heart ... Can angina pectoris be prevented?. Keeping up a healthy lifestyle can help to delay or prevent angina pectoris. A healthy ...
more infohttp://www.ahealthyme.com/Conditions/Neuroscience/85,P00194

Angina PectorisAngina Pectoris

Variant angina pectoris. (or Prinzmetals angina). *Is rare. *Occurs almost exclusively when a person is at rest ... Angina Pectoris. Conditions We Treat. Angina pectoris (or simply angina) is recurring chest pain or discomfort that happens ... Treatment of angina pectoris. Specific treatment for angina pectoris will be determined by the doctor based on:. * Your age, ... What are the symptoms of angina pectoris?. Angina pectoris occurs when the heart muscle (myocardium) does not receive an ...
more infohttp://www.lakelandhealth.org/medical-services/cardiology-services/heart-conditions/angina-pectoris

Vasospastic AnginaVasospastic Angina

... , Prinzmetals Angina, Variant Angina, Variant Angina Pectoris, Coronary Artery Vasospasm. ... angina, angina pectoris; variant, variant; angina, Angina pectoris, variant, Prinzmetal-angina, Variant angina pectoris. ... variant angina, Angina, Prinzmetal, VARIANT ANGINA, Prinzmetal angina, Prinzmetals angina, Variant angina pectoris, Variant ... Angina, Prinzmetals, Prinzmetal Angina, ANGINA VARIANT ,PRINZMETAL,, Variant Angina Pectoris, Variant Angina, variant angina ...
more infohttps://fpnotebook.com/CV/CAD/VspstcAngn.htm

Efficacy Study of Atorvastatin to Treat Variant Angina - Full Text View - ClinicalTrials.govEfficacy Study of Atorvastatin to Treat Variant Angina - Full Text View - ClinicalTrials.gov

Angina Pectoris. Angina Pectoris, Variant. Chest Pain. Pain. Neurologic Manifestations. Nervous System Diseases. Myocardial ... Efficacy Study of Atorvastatin to Treat Variant Angina (ESAVA). The recruitment status of this study is unknown. The completion ... Genetic and Rare Diseases Information Center resources: Prinzmetal's Variant Angina ... Vasospastic angina or spontaneous spasm during coronary angiography (Vasospastic angina is defined as Thrombolysis In ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00620204

Cardiovascular System - Fung Flashcards by Stephanie Rogers | BrainscapeCardiovascular System - Fung Flashcards by Stephanie Rogers | Brainscape

What are the variants of angina pectoris? 1. stable (most common). 2. prinzmetal. 3. unstable (crescendo) ... 1. angina pectoris. 2. MI. 3. chronic ischemic heart disease with heart failure. 4. sudden cardiac death (usually due to ...
more infohttps://www.brainscape.com/flashcards/cardiovascular-system-fung-3195121/packs/5063785

Dilacor XR  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | The Medicine ShoppeDilacor XR - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | The Medicine Shoppe

Angina Pectoris, Variant. *Atrial Fibrillation. *Atrial Flutter. *Hypertension. *Tachycardia, Supraventricular. How long have ...
more infohttps://www.medicineshoppe.com/dilacor-xr-0

Cardene  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | The Medicine ShoppeCardene - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | The Medicine Shoppe

Angina Pectoris, Variant. *Hypertension. How long have you been taking it?. Choose one ...
more infohttps://www.medicineshoppe.com/cardene

Similar articles for PubMed (Select 20159412) - PubMed - NCBISimilar articles for PubMed (Select 20159412) - PubMed - NCBI

Variant angina pectoris with demonstration of coronary spasm. Diagnostic and therapeutic considerations]. ... Variant (Prinzmetals) angina with diffuse coronary spasm without coronary sclerosis].. Willberg A, Lieb G, Nunberger D, ... Unstable angina, Prinzmetals variant and transient Q waves. Report of a case]. ... Variant angina and coronary artery spasm: the clinical spectrum, pathophysiology, and management. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=link&linkname=pubmed_pubmed&uid=20159412

Angina Pectoris			<span class=post-format-icon minor-meta>...Angina Pectoris <span class='post-format-icon minor-meta'>...

There are 2 other forms of angina pectoris. They are:. Variant angina pectoris. (or Prinzmetals angina) ... Angina pectoris-or simply angina-is chest pain or discomfort that keeps coming back. It happens when some part of your heart ... Angina pectoris-or simply angina-is chest pain or discomfort that keeps coming back. It happens when some part of your heart ... Angina Pectoris January 10, 2017. /in Aging Gracefully, Health Library, Health Library, Health Library, Health Library, In Full ...
more infohttps://www.awomansview.com/resources/young-on-your-way/angina-pectoris/

Calan  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiCalan - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

Angina Pectoris, Variant. *Hypertension. *Myocardial Infarction. *Tachycardia, Supraventricular. How long have you been taking ...
more infohttps://rxwiki.com/calan/

Verapamil  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiVerapamil - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

Angina Pectoris, Variant. *Hypertension. *Myocardial Infarction. *Tachycardia, Supraventricular. How long have you been taking ...
more infohttps://www.rxwiki.com/verapamil

Nicardipine  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiNicardipine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

Angina Pectoris, Variant. *Hypertension. How long have you been taking it?. Choose one ...
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Afeditab CR  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiAfeditab CR - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

Angina Pectoris, Variant. *Hypertension. How long have you been taking it?. Choose one ... Tell your healthcare provider right away if you have some or all of the following symptoms of angina:*a pressure, squeezing, ...
more infohttps://rxwiki.com/afeditab-cr

The Coronary Angiogram and Its Seminal Contributions to Cardiovascular Medicine Over Five Decades | CirculationThe Coronary Angiogram and Its Seminal Contributions to Cardiovascular Medicine Over Five Decades | Circulation

Angina pectoris: I. A variant form of angina pectoris. Am J Med. 1959; 27: 375-388. ... Coronary bypass surgery in stable angina pectoris: survival at two years. Lancet. 1979; 1: 889-893. ... the coronary angiogram not only provided objective evidence to support or refute the clinical diagnosis of angina pectoris but ... Coronary arterial spasm in Prinzmetal angina: documentation by coronary arteriography. N Engl J of Med. 1973; 288: 745-751. ...
more infohttp://circ.ahajournals.org/content/106/6/752.full?ijkey=c267fb2bc1db9ed6ea49af26f3c31346f09bb1db&keytype2=tf_ipsecsha

Angina Pectoris Clinical Presentation: History, Physical ExaminationAngina Pectoris Clinical Presentation: History, Physical Examination

Angina is a common presenting symptom (typically, chest pain) among patients with coronary artery disease. ... Angina pectoris is the result of myocardial ischemia caused by an imbalance between myocardial blood supply and oxygen demand. ... Angina decubitus. Angina decubitus is a variant of angina pectoris that occurs at night while the patient is recumbent. Some ... Angina Pectoris) and Angina Pectoris What to Read Next on Medscape. Related Conditions and Diseases. * Angina Pectoris ...
more infohttps://emedicine.medscape.com/article/150215-clinical

Effect of a new coronary vasodilator, nicorandil, on variant a...Effect of a new coronary vasodilator, nicorandil, on variant a...

... on variant angina pectoris.: The effect of nicorandil, a new coronary vasodilator, was evaluated in 32 patient ... Effect of a new coronary vasodilator, nicorandil, on variant angina pectoris.. Authors * Kishida, H ... The effect of nicorandil, a new coronary vasodilator, was evaluated in 32 patients with variant angina pectoris in a single- ... The results demonstrate the effectiveness of nicorandil in the treatment of variant angina pectoris. ...
more infohttps://www.mysciencework.com/publication/show/effect-new-coronary-vasodilator-nicorandil-variant-angina-pectoris-cd4f32d1

Angina in Non Coronary Artery Disease - Full Text View - ClinicalTrials.govAngina in Non Coronary Artery Disease - Full Text View - ClinicalTrials.gov

Angina Pectoris. Angina Pectoris, Variant. Chest Pain. Pain. Neurologic Manifestations. Nervous System Diseases. Myocardial ... Cause of angina equivalent symptoms in patients with no coronary artery disease [ Time Frame: One day ]. *Prognosis of patients ... Angina in Non Coronary Artery Disease (HeartQuest). This study is ongoing, but not recruiting participants. ... Schoenenberger AW, Felber S, Gujer S, Moser A, Jamshidi P, Stuck AE, Erne P. Invasive findings in patients with angina ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01318629?term=angina&lup_s=04%2F08%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14

NewYork-Presbyterian Queens - Angina PectorisNewYork-Presbyterian Queens - Angina Pectoris

Other types of angina pectoris. There are two other forms of angina pectoris, including:. Variant angina pectoris. (or ... What is angina pectoris?. Angina pectoris (or simply angina) is recurring chest pain or discomfort that happens when some part ... Angina Pectoris. Angina Vs. Heart Attack Angina may have similar symptoms to a heart attack, such as a crushing, squeezing pain ... Treatment of angina pectoris. Specific treatment for angina pectoris will be determined by the doctor based on:. *Your age, ...
more infohttp://www.nyhq.org/diw/Content.asp?PageID=DIW000194&language=Korean

NewYork-Presbyterian Queens - Heart Conditions in Adults - Angina PectorisNewYork-Presbyterian Queens - Heart Conditions in Adults - Angina Pectoris

Other types of angina pectoris. There are two other forms of angina pectoris, including:. Variant angina pectoris. (or ... What is angina pectoris?. Angina pectoris (or simply angina) is recurring chest pain or discomfort that happens when some part ... Treatment of angina pectoris. Specific treatment for angina pectoris will be determined by the doctor based on:. *Your age, ... Heart Conditions in Adults - Angina Pectoris. Angina Vs. Heart Attack Angina may have similar symptoms to a heart attack, such ...
more infohttp://www.nyhq.org/diw/Content.asp?PageID=DIW006303&More=WTN

Angina Pectoris | UCLA Health Library, Los Angeles, CAAngina Pectoris | UCLA Health Library, Los Angeles, CA

... or simply angina - is chest pain or discomfort that keeps coming back. It happens when some part of your heart does not get ... Variant angina pectoris. This is also called Prinzmetals angina. It is rare. It occurs almost only at rest, not after exercise ... Angina Pectoris. What is angina pectoris?. Angina pectoris is chest pain or discomfort that occurs when a part of your heart ... Can angina pectoris be prevented?. Keeping up a healthy lifestyle can help to delay or prevent angina pectoris. A healthy ...
more infohttp://healthinfo.uclahealth.org/Search/85,P00194

How It Works<...How It Works<...

Magnesium deficiency detected by intravenous loading test in variant angina pectoris. Am J Cardiol 1990;65:709-12. ... Cohen L, Kitzes R. Magnesium sulfate in the treatment of variant angina. Magnesium 1984;3:46-9. ... stimulus-induced vasoconstriction of different vascular beds by magnesium sulfate in patients with Prinzmetals angina. ...
more infohttps://www.evitamins.com/hk/encyclopedia/assets/nutritional-supplement/magnesium/how-it-works

How It Works<...How It Works<...

Magnesium deficiency detected by intravenous loading test in variant angina pectoris. Am J Cardiol 1990;65:709-12. ... Cohen L, Kitzes R. Magnesium sulfate in the treatment of variant angina. Magnesium 1984;3:46-9. ... stimulus-induced vasoconstriction of different vascular beds by magnesium sulfate in patients with Prinzmetals angina. ...
more infohttps://www.evitamins.com/de-ch/encyclopedia/assets/nutritional-supplement/magnesium/how-it-works

Angina PectorisAngina Pectoris

... -or simply angina-is chest pain or discomfort that keeps coming back. It happens when some part of your heart ... There are 2 other forms of angina pectoris. They are:. Variant angina pectoris. (or Prinzmetals angina) ... Angina Pectoris. What is angina pectoris?. Angina pectoris-or simply angina-is chest pain or discomfort that keeps coming back ... What causes angina pectoris?. Angina pectoris occurs when your heart muscle (myocardium) does not get enough blood and oxygen ...
more infohttp://myhealth.umassmemorial.org/Library/DiseasesConditions/Adult/Cardiovascular/85,P00194
  • 1,2 ⇓ As the first reliable in vivo marker for the presence of obstructing coronary lesions, the coronary angiogram not only provided objective evidence to support or refute the clinical diagnosis of angina pectoris but, quite importantly, led to our first studies of the natural history of patients with coronary artery disease (CAD). (ahajournals.org)
  • According to MD News , a clinical news magazine for physicians, there are approximately 500,000 new cases of angina pectoris diagnosed each year . (marijuanadoctors.com)
  • Percutaneous transmyocardial laser revascularisation for severe angina: the PACIFIC randomised trial. (medscape.com)