Gallbladder Diseases: Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Gallbladder: A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.Drug Discovery: The process of finding chemicals for potential therapeutic use.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Cholecystectomy: Surgical removal of the GALLBLADDER.Cholecystitis: Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.Emulsifying Agents: SURFACE-ACTIVE AGENTS that induce a dispersion of undissolved material throughout a liquid.Emulsions: Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.Anethole Trithione: Choleretic used to allay dry mouth and constipation due to tranquilizers.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Oils: Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Excipients: Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.Surface-Active Agents: Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Rhinitis, Vasomotor: A form of non-allergic rhinitis that is characterized by nasal congestion and posterior pharyngeal drainage.Xerostomia: Decreased salivary flow.Salivation: The discharge of saliva from the SALIVARY GLANDS that keeps the mouth tissues moist and aids in digestion.Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.Saliva: The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.Secretory Rate: The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).Nasal Decongestants: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)Mouth: The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.Brassica: A plant genus of the family Cruciferae. It contains many species and cultivars used as food including cabbage, cauliflower, broccoli, Brussel sprouts, kale, collard greens, MUSTARD PLANT; (B. alba, B. junica, and B. nigra), turnips (BRASSICA NAPUS) and rapeseed (BRASSICA RAPA).Isothiocyanates: Organic compounds with the general formula R-NCS.Brassica napus: A plant species of the family BRASSICACEAE best known for the edible roots.Brassica rapa: A plant species cultivated for the seed used as animal feed and as a source of canola cooking oil.Breast Neoplasms: Tumors or cancer of the human BREAST.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Vegetables: A food group comprised of EDIBLE PLANTS or their parts.Postmenopause: The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.Estrogens: Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.Pharmacies: Facilities for the preparation and dispensing of drugs.Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Pharmacy: The practice of compounding and dispensing medicinal preparations.Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Schools, Pharmacy: Educational institutions for individuals specializing in the field of pharmacy.Community Pharmacy Services: Total pharmaceutical services provided to the public through community pharmacies.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Education, Pharmacy, Graduate: Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.Pharmacy Service, Hospital: Hospital department responsible for the receiving, storing, and distribution of pharmaceutical supplies.Legislation, Pharmacy: Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.British Columbia: A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Femininity: Female-associated sex-specific social roles and behaviors unrelated to biologic function.Marketing of Health Services: Application of marketing principles and techniques to maximize the use of health care resources.United StatesDrug Costs: The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).Bedding and Linens: Articles of cloth, usually cotton or rayon and other synthetic or cotton-blend fabrics, used in households, hospitals, physicians' examining rooms, nursing homes, etc., for sheets, pillow cases, toweling, gowns, drapes, and the like.IrelandNorthern Ireland

Usefulness of basal and pilocarpine-stimulated salivary flow in primary Sjogren's syndrome. Correlation with clinical, immunological and histological features. (1/6)

OBJECTIVES: To examine salivary function in patients with primary Sjogren's syndrome (SS) by assessing unstimulated and stimulated flows using 5 mg of pilocarpine in a 5% solution, in order to define their clinical usefulness in the evaluation of xerostomia in patients with primary SS as well as to identify those factors related to the increase in salivary flow after pilocarpine stimulation. METHODS: We investigated the clinical and immunological characteristics of 60 consecutive patients with primary SS. All patients fulfilled four or more of the preliminary diagnostic European criteria for SS. We measured unstimulated (basal) salivary flow (BSF) in all patients. In patients with BSF +info)

A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia. (2/6)

BACKGROUND: Results from preclinical studies have suggested that the organosulfur compound anethole dithiolethione (ADT) may be an effective chemopreventive agent for lung cancer. We conducted a phase IIb study to determine the effects of ADT in smokers with bronchial dysplasia. METHODS: One hundred twelve current and former smokers with a smoking history of at least 30 pack-years and at least one site of bronchial dysplasia identified by an autofluorescence bronchoscopy-directed biopsy were randomly assigned to receive placebo or ADT at 25 mg orally thrice daily for 6 months. Each subject then underwent a follow-up bronchoscopy-directed biopsy. We used changes in histopathologic grade and nuclear morphometry index (MI) as the primary and secondary end point biomarkers, respectively. Chi-square tests with continuity correction were used to compare response rates on a lesion- and person-specific basis between the two study groups. All statistical tests were two-sided. RESULTS: One hundred one subjects had a follow-up bronchoscopy. In the lesion-specific analysis, progression rate of pre-existing dysplastic lesions by two or more grades and/or the appearance of new lesions was statistically significantly lower in the ADT group (8%) than in the placebo group (17%) (P<.001; difference = 9%, 95% confidence interval [CI] = 4% to 15%). In the person-specific analysis, the disease progression rate was statistically significantly lower in the ADT group (32%) than in the placebo group (59%) (P =.013; difference = 27%, 95% CI = 6% to 48%). The two treatment groups did not differ statistically significantly in terms of nuclear MI. Among individuals with an abnormal nuclear MI before treatment (29 in the ADT group and 25 in the placebo group), the progression rate in the ADT group (41%) was substantially lower than that in the placebo group (60%), although the difference was not statistically significant (P =.28; difference = 19%, 95% CI = -11% to 49%). Adverse events were mostly minor gastrointestinal symptoms that resolved with dose reduction or discontinuation of the medication. CONCLUSION: Our results suggest that, in smokers, ADT is a potentially efficacious chemoprevention agent for lung cancer.  (+info)

Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid. (3/6)

BACKGROUND AND PURPOSE: Angiogenesis involves multiple signaling pathways that must be considered when developing agents to modulate pathological angiogenesis. Because both cyclooxygenase inhibitors and dithioles have demonstrated anti-angiogenic properties, we investigated the activities of a new class of anti-inflammatory drugs containing dithiolethione moieties (S-NSAIDs) and S-valproate. EXPERIMENTAL APPROACH: Anti-angiogenic activities of S-NSAIDS, S-valproate, and the respective parent compounds were assessed using umbilical vein endothelial cells, muscle and tumor tissue explant angiogenesis assays, and developmental angiogenesis in Fli:EGFP transgenic zebrafish embryos. KEY RESULTS: Dithiolethione derivatives of diclofenac, valproate, and sulindac inhibited endothelial cell proliferation and induced Ser(78) phosphorylation of hsp27, a known molecular target of anti-angiogenic signaling. The parent drugs lacked this activity, but dithiolethiones were active at comparable concentrations. Although dithiolethiones can potentially release hydrogen sulphide, NaSH did not reproduce some activities of the S-NSAIDs, indicating that the dithioles regulate angiogenesis through mechanisms other than release of H(2)S. In contrast to the parent drugs, S-NSAIDs, S-valproate, NaSH, and dithiolethiones were potent inhibitors of angiogenic responses in muscle and HT29 tumor explants assessed by 3-dimensional collagen matrix assays. Dithiolethiones and valproic acid were also potent inhibitors of developmental angiogenesis in zebrafish embryos, but the S-NSAIDs, remarkably, lacked this activity. CONCLUSIONS AND IMPLICATION: S-NSAIDs and S-valproate have potent anti-angiogenic activities mediated by their dithiole moieties. The novel properties of S-NSAIDs and S-valproate to inhibit pathological versus developmental angiogenesis suggest that these agents may have a role in cancer treatment.  (+info)

Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. (4/6)

 (+info)

Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent. (5/6)

 (+info)

Chemoprevention of colon carcinogenesis by organosulfur compounds. (6/6)

It has been reported that several naturally occurring and related synthetic organosulfur compounds exert chemopreventive effects in several target organs in rodent models. The chemopreventive actions of 40 and 80% maximum tolerated doses (MTD) of organosulfur compounds, namely anethole trithione, diallyl disulfide, N-acetylcysteine, and taurine, administered in AIN-76A diet, on azoxymethane (AOM)-induced neoplasia were investigated in male F344 rats. Also, the effects of these agents on the activities of phase II enzymes, namely glutathione S-transferase (GST), NAD(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase, in the liver and colonic mucosa and tumors were assessed. The MTD levels of anethole trithione, diallyl disulfide, N-acetylcysteine, and taurine were determined in male F344 rats and found to be 250, 250, 1500, and 1500 ppm, respectively. At 5 weeks of age, animals were fed the control diet (AIN-76A) or experimental diets containing 40 or 80% MTD levels of each test agent. All animals in each group, except those allotted for vehicle (saline) treatment, were administered AOM s.c. at a dose rate of 15 mg/kg body weight once weekly for 2 weeks. All animals were necropsied during week 52 after the second AOM injection. Colonic mucosal and tumor and liver enzyme activities were measured in animals fed 80% MTD levels of each test agent. Colon tumors were subjected to histopathological evaluation and classified as invasive or noninvasive adenocarcinomas. Colon tumor incidence (percentage of animals with tumors) and tumor multiplicity (tumors/animal) were compared among various dietary groups. The results indicated that administration of 200 ppm (80% MTD) anethole trithione significantly inhibited the incidence and multiplicity of both invasive and noninvasive adenocarcinomas, whereas feeding of 100 ppm (40% MTD) anethole trithione or 100 (40% MTD) or 200 ppm (80% MTD) diallyl disulfide suppressed only invasive adenocarcinomas of the colon. Although diets containing N-acetylcysteine and taurine inhibited colon tumor multiplicity, the effect was somewhat marginal. GST, NAD-(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase activities in colonic mucosa and tumor and liver were significantly elevated in animals fed anethole trithione or diallyl disulfide, compared to those fed the control diet. N-Acetylcysteine and taurine slightly but significantly increased only the GST activity in the liver. Although other mechanisms are not excluded, inhibition of AOM-induced colon carcinogenesis by anethole trithione and diallyl disulfide may be associated, in part, with increased activities of phase II enzymes such as GST, NAD(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase in the liver and colon.  (+info)

*Self-microemulsifying drug delivery system

Jing Q; Shen Y; Ren F; Chen J; Jiang Z; Peng B; Leng Y; Dong J (November 2006). "HPLC determination of anethole trithione and ... SMEDDS in research or development include formulations of the drugs anethole trithione, oridonin, curcumin, vinpocetine, ... It employs the familiar ouzo effect displayed by anethole in many anise-flavored liquors. Microemulsions have significant ...

*Anethole trithione

... , anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. It is listed in ... Anethole trithione is an organosulfur compound, specifically, a dithiole-thione derivative. Felviten Halpen Hepasulfol - Franco ... EG Labo Tiopropen Tiotrifar Anethole Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. Retrieved ...

*Acetanisole

Sulfarlem (Anethole trithione) for treating Parkinson's disease. At room temperature 4-Methoxyacetophenone is solid, and has a ...

*List of MeSH codes (D02)

... anethole trithione MeSH D02.355.601.200.324 --- butylated hydroxyanisole MeSH D02.355.601.250 --- bis(chloromethyl) ether MeSH ... anethole trithione MeSH D02.355.726.158.324 --- butylated hydroxyanisole MeSH D02.355.726.453 --- guaiacol MeSH D02.355.726.453 ... anethole trithione MeSH D02.755.075.241 --- butylated hydroxyanisole MeSH D02.755.075.536 --- guaiacol MeSH D02.755.075.536.400 ...

*ATC code A16

A16AB16 Idursulfase beta A16AB17 Cerliponase alfa A16AB18 Vestronidase alfa A16AX01 Thioctic acid A16AX02 Anethole trithione ...
A matrix isolation study of the infrared spectra and structure of anethole (1-methoxy-4-(1-propenyl)benzene) has been carried out, showing the presence of two E conformers (AE1, AE2) of the molecule in the as-deposited matrices. Irradiation using ultraviolet-tunable laser light at 308-307 nm induced conformationally selective phototransformations of these forms into two less stable Z conformers (AZ1, AZ2). The back reactions were also detected upon irradiation at 301 nm. On the whole, the obtained results allow for full assignment of the infrared spectra of all the four experimentally observed anethole isomers and showed that the narrowband UV-induced E-Z photoisomerization is an efficient and selective way to interconvert the two isomers of anethole into each other, with conformational discrimination. Photolysis of anethole was observed as well, with initial methoxyl O-C bond cleavage and formation of CH{sub 3} and p-propenylphenoxy (AR) radicals, followed by radical recombination to form ...
Author: Dyke Shannon, Year: 2000, Abstract: As many as 3% of Americans suffer from Sjogrens syndrome, which affects populations worldwide and in all age groups. In this article, the author discusses the pathogenesis, symptoms and diagnosis of this disorder and treatment of ocular and oral symptoms (tear substitutes, antifungals, saliva substitutes, pilocarpine, anethole trithione, yohimbine and human interferon alpha). She also provides three formulas (Sodium Fluoride Gel [0.5% Fluoride] - 100 mL, Clotrimazole 10-mg Base A Troche - 24 Tr
Are you looking for some tips on fennel & other essential oils with (E)-anethole? From safety concerns, therapeutic actions, and applications you can find it...
soluble salts are particularly suitable. especially the benzanthrone sulfonic acids. Patented May 5, 1942 PATENT OFFICE LIGHT SENSITIVE MATERIAL Gottlieb von Poser, Wiesbaden, and Maximilian Paul Schmidt, Wiesbaden-Biebrich, Germany No Drawing. Application November 14, 1940, Se- rial No. 365,652. In Germany Claims. The present invention relates to light sensitive materials which may be used for photographic purposes. It is known that the light-sensitiveness of such organic dyestuffs as change their color or bleach out on exposure to light may be enhanced by adding sensitizers to the dyestufls.-. As such sensitizers there have been proposed, for instance, thiosinamine and anethole. By applying combinations of suitable dyestuffs with such. sensitizers on paperior a similar support, light-sensibasic groups, preferably amino groups. are also suitable triphenylmethane dyestuffs for tive materials are obtained which may be used for photographic purposes. Such light-sensitive materials, however, have ...
Thrombosis is defined as a condition of formation of a blood clot inside a blood vessel, leading to the obstruction of blood flow of the circulatory system. Anrise can help to reduce the risk of thrombosis due to the essential oil anethole, according to the study of "Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis" by Tognolini M, Ballabeni V, Bertoni S, Bruni R, Impicciatore M, Barocelli E., posted in PubMed (2), researchers found that both F. vulgare essential oil and anethole (100 mg kg(-1) oral administration) provided significant protection toward ethanol induced gastric lesions in rats. In conclusion, these results demonstrate for F. vulgare essential oil, and its main component anethole, a safe antithrombotic activity that seems due to their broad spectrum antiplatelet activity, clot destabilizing effect and vasorelaxant action ...
para-Methoxyamphetamine (PMA; "Death", "Dr. Death"), also known as 4-methoxyamphetamine (4-MA), is a designer drug of the amphetamine class with serotonergic effects. Unlike other similar drugs of this family, PMA does not produce stimulant, euphoriant, or entactogen effects, and behaves more like an antidepressant in comparison,[citation needed] though it does have some psychedelic properties. PMA has been found in tablets touted as MDMA (ecstasy) although its effects are markedly different compared to those of MDMA. The consequences of such deception have often included hospitalization and death for unwitting users. PMA is commonly synthesized from anethole, the flavor compound of anise and fennel, mainly because the starting material for MDMA, safrole, has become less available due to law enforcement action, causing illicit drug manufacturers to use anethole as an alternative. PMA has been associated with numerous adverse reactions including death. Effects of PMA ingestion include many ...
Progress in the field of fluorescence bronchoscopy has made it possible to locally diagnose bronchial dysplasia, thought sometimes to be the precancerous lesions of squamous cell carcinoma. We have recently reported the results of extensive studies of dysplasia in bronchial mucosa using white light bronchoscopy combined with fluorescence bronchoscopy.3 However, it proved impossible, even with a BF240 bronchovideoscope, to obtain findings other than swelling and redness in bronchial bifurcations, as previously reported.12,13 Because of the difficulty in diagnosing dysplasia by white light bronchoscopy, we attempted to obtain detailed white light observations of bronchial dysplasia using a direct viewing high magnification bronchovideoscope with the aim of developing a new method of bronchoscopic diagnosis.. In gastrointestinal endoscopy, high magnification endoscopy has been developed for observing and analysing epithelial microstructures. Moreover, there have been several recent reports on the ...
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radical, which can be toxic. Prince M, Li Y, Childers A, Itoh K, Yamamoto M, Kleiner HE (March 2009). "Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice". Toxicol. Lett. 185 (3): 180-6. doi:10.1016/j.toxlet.2008.12.014. PMC 2676710 . PMID 19150646. Zhang Y, Gordon GB (July 2004). "A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway". Mol. Cancer Ther. 3 (7): 885-93. PMID 15252150. Iida K, Itoh K, Kumagai Y, et al. (September 2004). "Nrf2 is ...
Terpene General Background, 8-Cineole, α-amyrin, α-Pinene, Anethole, Anti-microbial general, Antitumor Monoterpenes, Beta-Caryophyllene, Betulinic acid
Terpene General Background, 8-Cineole, α-amyrin, α-Pinene, Anethole, Anti-microbial general, Antitumor Monoterpenes, Beta-Caryophyllene, Betulinic acid
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of Polyphenon E, a substance found in green tea, may keep ca
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OBJECTIVES: I. Determine the efficacy of inhaled budesonide on the number and grade of bronchial epithelial dysplastic lesions in former and current smokers. II. Compare the effect of inhaled budesonide vs placebo in modulating several intermediate biomarkers (i.e., proliferation, apoptosis, morphometric, and methylation markers) in this patient population. III. Correlate the regression of bronchial dysplasia (number and grade) and improvement in sputum cytology (morphometric grade of atypical cells) with the modulations in molecular biomarkers in this patient population. IV. Compare the stability of the chemopreventive effect of these treatment regimens at six months after completion of these regimens in these patients. V. Compare the safety of these treatment regimens in these patients.. OUTLINE: This is a randomized, double-blind, placebo-controlled study. Patients are stratified according to gender, smoking status (current vs former), and morphometric index (no greater than 3.4 vs greater ...
actinole adrigole aerosoul agricole air-hole ale-pole altivole amitrole anethole annopole anticoal antigoal antihole antipole antiroll antitoll arm-hole arsehole arvicole asystole attomole autoroll autotoll backroll baggbole balokole bandrole bankroll barnsole basshole beadroll beanhole beanpole bed-roll belepole benapole bendroll betazole bettolle blogroll blowhole bocicoel boerboel bolthole bootsole borazole borecole borehole braciole bradpole brewpole briciole brignole britbowl bromvoel bunghole butthole buttsole c-scroll cabriole cakehole camisole capitoll capreole capriole caracole carneole carriole cat-hole ceresole chandole charcoal chetnole chrisole chughole claypole clodpole clypeole coalhole coloroll conazole copstole corehole corneole cornhole crabhole craphole cum-hole day-coal decimole delabole denehole deyrolle diacoele diarsole diastole dib-hole dickhole diindole dimazole disenrol ditazole dithiole dog-hole downhole drumroll drupeole duckhole duckmole dunghole dustbowl dyastole ...
Introduction and objectives Improving the early detection and chemoprevention of lung cancer are key to improving outcomes. The pathobiology of early squamous lung cancer is poorly understood. We have shown in a previous publication that amplification of SOX2 is an early and consistent event in the pathogenesis of this disease but its functional oncogenic potential remains uncertain. We aimed to test the impact of deregulated SOX2 expression in a novel organotypic system that recreates both the molecular and microenvironmental context in which squamous carcinogenesis occurs.. Our objectives are: ...
How bad is it to take advil or tylenol for a hangover - How bad is it to take Advil or tylenol (acetaminophen) for a hangover? Not bad. Its not bad, just remember to drink lots of fluids and dont take them on an empty stomach. The better solution is to try and not get a hangover in the first place. You can do this by not drinking excessively and staying hydrated. If youre getting hangovers every time you drink, then you should think long and hard about your drinking habits.
Cold sores are caused by the Herpes virus, commonly HSV 1 but can also be caused be caused by simplex 2. There are no known cures, as of right now, but essential oils that are rich in antiviral and anti-inflammatory compounds will help to reduce outbreaks and help to heal them faster. Essential oils are comprised of many different chemical constituents, and many of these constituents are antiviral, such as: Anethole Beta-caryophyllene Carvone Cinnamic aldehyde Citral Citronellol Eugenol Limonene Linalool […] ...
FENNEL. The same oils found in anise are found in fennel, giving both the tell-tale odor and taste of licorice. One of these oils, anethole, is believed to have anti-fungal and anti-bacterial properties. Known primarily for its use in Italian dishes, the fennel bulb contains the B vitamin complex but boasts a high amount of folate in particular. Fennel also contains vitamin C, calcium, copper, iron, magnesium, manganese, potassium, selenium and zinc.. The fennel bulb, which resembles a fattened celery bunch base, can be sliced thin and eaten raw in salads. In its raw form, it has a fresh, cool, mild flavor. To impart more of an anise flavor, cook the fennel. Any cooking method that induces caramelization, such as braising, roasting or grilling, will add a sweet element close to candied licorice. The entire plant is edible. So dont toss the dill-like leaves which can be utilized like an herb in any dish.. ...
Bronchial emphysema, bronchial atresia surgery, bronchial epithelium and smoking, bronchial congestion lungs and pediatric bronchial pneumonia treatment. Bronchial tapping procedure, bronchial hyperresponsiveness asthma, how to perform bronchial tapping pediatric patients and bronchial walls or bronchial dysplasia symptoms.
... : safety - Allergies - Avoid with known allergy or hypersensitivity to anise (-Pimpinella anisum-), its constituents, or members of the Apiaceae family, including celery, coriander, cumin, dill, and fennel. Some toothpastes contain anethole, a constituent of anise, which may cause contact allergy. Anaphylaxis, contact allergy, gastrointestinal symptoms, hives, lip inflammation, loss of taste sensation,...
2.4.4.Gangguan pernafasan, seperti batuk, sesak ringan karena asma.. 2.4.5.Melancarkan ASI.. 2.4.6.Mengatasi kesulitan tidur.. 2.4.7.Mengurangi poteinuria (penyebab tertentu).. 2.4.8.Gangguan akibat batu di saluran kencing.. 2.4.9.Gangguan akibat radang persendian. 2.4.10.Gangguan haid (datang bulan), misalnya nyeri waktu haid (dysmenorrhea).. 2.4.11.Sebagai obat luar (untuk luka) (1).. Pemanfaatan sebagai pengobatan alternatif masih belum didukung oleh penelitian, kecuali mungkin 2.4.3. dan 2.4.10. (3,4,7).. 3.Kandungan kimia. Adas mengandung minyak astiri (Oleum Foeniculi), anetol (anethole), fenkon (fenchone), pinen (alfa pinene), limonen, dipenten, felandren (alfa phellandrene), metilchavikol, anisaldehid, asam anisat, dan minyak lemak. Anetol kandungan Adas mengeluarkan aroma yang khas dan berkhasiat karminatif (menghilangkan rasa nyeri kolik akibat gas). (1,4).. 4.Penelitian. Diantara hasil penelitian Adas yang berhasil dikumpulkan:. 4.1.H. Özbek (2003) dengan Judul : Hepatoprotective ...
Also known as aniseed, anise (Pimpinella anisum) is an annual herb perhaps best known for its signature licorice-like flavor and spicy-sweet scent. It can reach a height of 2 feet, is covered in soft hairs, and bears white flowers and oblong schizocarp fruits. Aniseed should not be confused with star anise (Illicium verum), which is an entirely different plant that merely shares a similar flavor and scent profile. Aniseed is cultivated in southern Europe, Turkey, central Asia, India, China, and Japan, as well as Central and South America.. Anise seeds naturally contain flavonoids and fatty oils, as well as its main component anethole. These seeds have been used in cuisines around the world for their licorice-like flavor, and are popularly distilled to extract their spicy-sweet smelling essential oil. Anise seeds have also been used in ancient Egypt to make tea, by ancient Roman naturalist Pliny the Elder, and in traditional European wellness practices for an array of applications, such as in ...
Fennel is an aromatic herb and a member of the carrot family. It has a large pale green bulb, celery-like stems and feathery leaves. Sliced thinly, the fennel bulb can be used in salads or served with other vegetables and a dip. Uncooked fennel has a mild licorice flavor and crunchy texture. When fennel is cooked, the flavor becomes more delicate and the texture softens. Fennel can be sauteed, braised, baked and added to soups or stews. The feathery leaves have an even milder flavor and can be used in soups and salads or as a garnish.. Fennel contains a combination of phytonutrients that gives it strong antioxidant properties. It is one phytonutrient, anethole, that has been used in studies and proven to reduce inflammation and help reduce the risk of cancer. Fennel has been used to treat various digestive symptoms, including heartburn, gas and bloating.. Fennel is entirely edible. Cook the stalks as you would the bulb, or top dished with chopped fronds for garnish. Thoroughly rinse Fennel as ...
ISI Document Delivery No.: CJ8OP Times Cited: 0 Cited Reference Count: 50 Haywood, Tom Kealey, Steven Sanchez-Cabezas, Santiago Hall, James J. Allott, Louis Smith, Graham Plisson, Christophe Miller, Philip W. EPSRC [EP/L025140/1]; Royal Society [RG110449]; Imperial College-EPSRC Kick-Start programme We are grateful to the EPSRC (grant no. EP/L025140/1), The Royal Society (grant no. RG110449) and to the Imperial College-EPSRC Kick-Start programme for supporting this work. 0 WILEY-V C H VERLAG GMBH WEINHEIM CHEM-EUR ...
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Fennel has become a common word in shows that air lifestyle news. It is a fresh vegetable that belongs to the Umbelliferae family. Physically it composes of three parts; a bulb that is white or pale green closely arranged stalks growing from the bulb and feathery green leaves. Its flowers sprout above the leaves where they produce the fennel seeds. All the parts of fennel are edible. The vegetable is slightly sweet and crunchy and mostly associated with Italian cooking. The season for this vegetable is from the autumn through to the early season of spring. Food rating systems have rated fennel as either a good or excellent source of nutrients. This article discusses the various nutritional benefits that one derives from eating fennel.. Prevent against inflammation and occurrence of cancer. Fennel is known to contain a unique combination of phytonutrients that act as antioxidants that protect the body against inflammation. Anethole is the most active phytonutrient component in fennel. It is the ...
This very decorative spice is obtained by drying the star-shaped fruits of a small evergreen tree native to China. Despite the name, suggesting a connection with the common anise (pimpinella anisum) the two are not related. Anise is a member of the apiaceae family and native mostly to the Mediterranean region, while star anise comes from the shisandraceae family and is native to China. They do, however, have something in common, and that is the presence of anethole, which gives them their distinctive flavor. This accounts for the similarity in names ...
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Garlic (Allium sativum L.) has been used for culinary and medicinal purposes by many cultures for centuries (1). Garlic is a particularly rich source of organosulfur compounds, which are thought to be responsible for its flavor and aroma, as well as its potential health benefits (2). Consumer interest in the health benefits of garlic is strong enough to place it among the best-selling herbal supplements in the United States (3). Scientists are interested in the potential for organosulfur compounds derived from garlic to prevent and treat chronic diseases, such as cancer and cardiovascular disease.. Summary. * Garlic (Allium sativum L.) is a particularly rich source of organosulfur compounds, which are currently under investigation for their potential to prevent and treat disease. * Crushing or chopping garlic releases an enzyme called alliinase that catalyzes the formation of allicin. Allicin rapidly breaks down to form a variety of organosulfur compounds. * Since cooking can inactivate ...
Various plants have been used to relieve of infant colic, including catmint (Nepeta cataria), chamomille (Matricaria chamomilla), dill (Anethum graveolens), fennel (Foeniculum vulgare), lemon balm (Melissa officinalis), and others. Among these plants, fennel is the most frequently recommended by herbologists and naturopaths. All of these listed plants are rich in volatile oils, and their beneficial effect is attributed to volatile oils. The highest concentration of the fennel oil, ranging from 2 to 7%, is found in the seeds of fennel. Fennel volatile oil is a mixture of at least a dozen of different chemicals. The main component of fennel seed oil is anethole. Animal experiments have shown that fennel oil regulates contractility of the small intestine (36, 37, 38). Anethole has a chemical structure similar to a chemical naturally present in the body, called dopamine. Dopamine is known to have a relaxing effect on the intestine and beneficial effect of fennel oil in baby colic is attributed to ...
A low compression, resilient golf ball having a center and a cover, made from a polybutadiene reaction product having polybutadiene, a cis-to-trans catalyst including an organosulfur component, and a free radical source. The reaction product has a first dynamic stiffness measured at −50 C. that is less than about 130 percent of a second dynamic stiffness measured at 0 C. A multi-layer golf ball having a center, at least one intermediate layer disposed concentrically about the center, and a cover. At least a portion of at least one of the center, intermediate layer, or both, are made from a reaction product including polybutadiene having a cis-to-trans catalyst that includes at least one organosulfur component and a free radical source. The reaction product has a first dynamic stiffness measured at −50 C. that is less than about 130 percent of a second dynamic stiffness measured at 0 C. Addition of various combinations of polybutadiene, cis-to-trans catalyst including at least one organosulfur
Extracts of fresh garlic, or Allium sativum, that are aged over a prolonged period contain antioxidant phytochemicals that fight against oxidant damage. These antioxidant phytochemicals include unique water-soluble organosulfur compounds, lipid-soluble organosulfur components and flavonoids, notably allixin and selenium. Longterm extraction of garlic (up to 20 months) ages the extract, retaining garlic nutrients while creating antioxidant properties by modifying unstable molecules with antioxidant activity, such as allicin. This aging process also increases stable and highly bioavailable organosulfur compounds, such as Sallylcysteine and S allylmercaptocysteine more antioxidant phytochemicals. And the aging process results in a truly odorless supplement. As a result, in addition to offering heart, brain, colon and other health benefits, AGE works as a powerful antioxidant, age-defying supplement by scavenging those pesky ROS, enhancing certain cellular antioxidant enzymes and increasing ...
1574 Epidemiological data continues to support the notion that increased consumption of Allium vegetables may reduce the risk for different types of malignancies including cancer of the prostate. Moreover, allium vegetable derived organosulfur compounds, such as diallyl trisulfide (DATS; CH2=CH-CH2-(S)3-CH2-CH=CH2), are highly effective in affording protection against cancer development in animal models. Evidence is mounting to indicate that garlic-derived organosulfur compounds can suppress proliferation of cultured cancer cells by inhibiting cell cycle progression and causing apoptosis induction. Previous studies including those from our laboratory have offered novel insights into the mechanism of apoptosis induction by DATS. For instance we showed previously that DATS-induced apoptosis in PC-3 and DU145 human prostate cancer cells was associated with c-jun N-terminal kinase mediated phosphorylation of Bcl-2, which reduced Bax-Bcl-2 interaction to trigger activation of caspase-9/3. In the ...
Natural organosulfur compounds (OSCs) have been shown to have chemopreventive effects and to suppress the proliferation of tumor cells in vitro through the induction of apoptosis. The biochemical mech
Looking for Disulphide? Find out information about Disulphide. A compound that has two sulfur atoms bonded to a radical or element. One of a group of organosulfur compounds RSSR′ that may be symmetrical or unsymmetrical Explanation of Disulphide
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0091]The composition of the first or second mantle layer (22 or 40) may also contain an organosulfur compound or a metal salt thereof in addition to the base rubber and the unsaturated carboxylic acid metal salt, such as those disclosed in copending U.S. patent application Ser. No. 09/951,963 (now U.S. Pat. No. 6,635,716), the entirety of which is incorporated herein by reference. The addition of such organosulfur compounds to base rubber compositions exhibit increased COR, decreased compression, or both. The organosulfur compound or metal salt thereof is preferably a halogenated organosulfur compound, and more preferably a halogenated thiophenol, including, but not limited to, pentafluorothiophenol; 2-fluorothiophenol; 3-fluorothiophenol; 4-fluorothiophenol; 2,3-fluorothiophenol; 2,4-fluorothiophenol; 3,4-fluorothiophenol; 3,5-fluorothiophenol 2,3,4-fluorothiophenol; 3,4,5-fluorothiophenol; 2,3,4,5-tetrafluorothiophenol; 2,3,5,6-tetrafluorothiophenol; 4-chlorotetrafluorothiophenol; ...
The green onion is an unassuming little vegetable. Its generally content to hang around in the background of many dishes, including much of what you find at our Seattle Korean restaurant, rarely ever drawing notice to itself. In case youve ever paid them any thought, though, its worth noting the many health benefits that the green onion offers.. A typical vegetable, the green onion is low in calories and features no fat or cholesterol. A single stalk of the plant offers ten percent of your recommended daily intake of vitamin A, nine percent of your vitamin C, and a touch of calcium and iron.. Green onions also contain organosulfur compounds. These compounds are good for preventing the decline of your cartilage as you age. A diet rich on organosulfur compounds can therefore help you avoid osteoarthritis, a painful condition associated with the atrophy of cartilage in the joints.. Quercetin, a valuable flavonoid found in green onions, is a valuable part of a healthy body. Not only does it ...
Sulfur represents approximately 1/4% of our total body weight and occurs principally in the body as a constituent of the cysteine and methionine. It plays an important role in protein synthesis and enzyme reaction functions and is found abundantly in broccoli, cauliflower, cabbage, kale, kohlrabi, etc. Organosulfides Organosulfur compounds presented in natural food are generally …. ...

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