Anisoles
Pimpinella
Diclofenac
Carcinoma, Non-Small-Cell Lung
Sulindac
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Valproic Acid
Emulsifying Agents
Emulsions
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Drug Delivery Systems
Chemistry, Pharmaceutical
Oils
Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)
Solubility
Thyroid (USP)
Salivary Glands
Submandibular Gland
One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Gallbladder Diseases
Research Report
Gallbladder
Dietetics
Breast
Risk Factors
Prospective Studies
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Brassica
Brassica rapa
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Morphinans
Datura
Dose-Response Relationship, Drug
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21)
Usefulness of basal and pilocarpine-stimulated salivary flow in primary Sjogren's syndrome. Correlation with clinical, immunological and histological features. (1/6)
OBJECTIVES: To examine salivary function in patients with primary Sjogren's syndrome (SS) by assessing unstimulated and stimulated flows using 5 mg of pilocarpine in a 5% solution, in order to define their clinical usefulness in the evaluation of xerostomia in patients with primary SS as well as to identify those factors related to the increase in salivary flow after pilocarpine stimulation. METHODS: We investigated the clinical and immunological characteristics of 60 consecutive patients with primary SS. All patients fulfilled four or more of the preliminary diagnostic European criteria for SS. We measured unstimulated (basal) salivary flow (BSF) in all patients. In patients with BSF +info)A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia. (2/6)
BACKGROUND: Results from preclinical studies have suggested that the organosulfur compound anethole dithiolethione (ADT) may be an effective chemopreventive agent for lung cancer. We conducted a phase IIb study to determine the effects of ADT in smokers with bronchial dysplasia. METHODS: One hundred twelve current and former smokers with a smoking history of at least 30 pack-years and at least one site of bronchial dysplasia identified by an autofluorescence bronchoscopy-directed biopsy were randomly assigned to receive placebo or ADT at 25 mg orally thrice daily for 6 months. Each subject then underwent a follow-up bronchoscopy-directed biopsy. We used changes in histopathologic grade and nuclear morphometry index (MI) as the primary and secondary end point biomarkers, respectively. Chi-square tests with continuity correction were used to compare response rates on a lesion- and person-specific basis between the two study groups. All statistical tests were two-sided. RESULTS: One hundred one subjects had a follow-up bronchoscopy. In the lesion-specific analysis, progression rate of pre-existing dysplastic lesions by two or more grades and/or the appearance of new lesions was statistically significantly lower in the ADT group (8%) than in the placebo group (17%) (P<.001; difference = 9%, 95% confidence interval [CI] = 4% to 15%). In the person-specific analysis, the disease progression rate was statistically significantly lower in the ADT group (32%) than in the placebo group (59%) (P =.013; difference = 27%, 95% CI = 6% to 48%). The two treatment groups did not differ statistically significantly in terms of nuclear MI. Among individuals with an abnormal nuclear MI before treatment (29 in the ADT group and 25 in the placebo group), the progression rate in the ADT group (41%) was substantially lower than that in the placebo group (60%), although the difference was not statistically significant (P =.28; difference = 19%, 95% CI = -11% to 49%). Adverse events were mostly minor gastrointestinal symptoms that resolved with dose reduction or discontinuation of the medication. CONCLUSION: Our results suggest that, in smokers, ADT is a potentially efficacious chemoprevention agent for lung cancer. (+info)Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid. (3/6)
BACKGROUND AND PURPOSE: Angiogenesis involves multiple signaling pathways that must be considered when developing agents to modulate pathological angiogenesis. Because both cyclooxygenase inhibitors and dithioles have demonstrated anti-angiogenic properties, we investigated the activities of a new class of anti-inflammatory drugs containing dithiolethione moieties (S-NSAIDs) and S-valproate. EXPERIMENTAL APPROACH: Anti-angiogenic activities of S-NSAIDS, S-valproate, and the respective parent compounds were assessed using umbilical vein endothelial cells, muscle and tumor tissue explant angiogenesis assays, and developmental angiogenesis in Fli:EGFP transgenic zebrafish embryos. KEY RESULTS: Dithiolethione derivatives of diclofenac, valproate, and sulindac inhibited endothelial cell proliferation and induced Ser(78) phosphorylation of hsp27, a known molecular target of anti-angiogenic signaling. The parent drugs lacked this activity, but dithiolethiones were active at comparable concentrations. Although dithiolethiones can potentially release hydrogen sulphide, NaSH did not reproduce some activities of the S-NSAIDs, indicating that the dithioles regulate angiogenesis through mechanisms other than release of H(2)S. In contrast to the parent drugs, S-NSAIDs, S-valproate, NaSH, and dithiolethiones were potent inhibitors of angiogenic responses in muscle and HT29 tumor explants assessed by 3-dimensional collagen matrix assays. Dithiolethiones and valproic acid were also potent inhibitors of developmental angiogenesis in zebrafish embryos, but the S-NSAIDs, remarkably, lacked this activity. CONCLUSIONS AND IMPLICATION: S-NSAIDs and S-valproate have potent anti-angiogenic activities mediated by their dithiole moieties. The novel properties of S-NSAIDs and S-valproate to inhibit pathological versus developmental angiogenesis suggest that these agents may have a role in cancer treatment. (+info)Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. (4/6)
(+info)Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent. (5/6)
(+info)Chemoprevention of colon carcinogenesis by organosulfur compounds. (6/6)
It has been reported that several naturally occurring and related synthetic organosulfur compounds exert chemopreventive effects in several target organs in rodent models. The chemopreventive actions of 40 and 80% maximum tolerated doses (MTD) of organosulfur compounds, namely anethole trithione, diallyl disulfide, N-acetylcysteine, and taurine, administered in AIN-76A diet, on azoxymethane (AOM)-induced neoplasia were investigated in male F344 rats. Also, the effects of these agents on the activities of phase II enzymes, namely glutathione S-transferase (GST), NAD(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase, in the liver and colonic mucosa and tumors were assessed. The MTD levels of anethole trithione, diallyl disulfide, N-acetylcysteine, and taurine were determined in male F344 rats and found to be 250, 250, 1500, and 1500 ppm, respectively. At 5 weeks of age, animals were fed the control diet (AIN-76A) or experimental diets containing 40 or 80% MTD levels of each test agent. All animals in each group, except those allotted for vehicle (saline) treatment, were administered AOM s.c. at a dose rate of 15 mg/kg body weight once weekly for 2 weeks. All animals were necropsied during week 52 after the second AOM injection. Colonic mucosal and tumor and liver enzyme activities were measured in animals fed 80% MTD levels of each test agent. Colon tumors were subjected to histopathological evaluation and classified as invasive or noninvasive adenocarcinomas. Colon tumor incidence (percentage of animals with tumors) and tumor multiplicity (tumors/animal) were compared among various dietary groups. The results indicated that administration of 200 ppm (80% MTD) anethole trithione significantly inhibited the incidence and multiplicity of both invasive and noninvasive adenocarcinomas, whereas feeding of 100 ppm (40% MTD) anethole trithione or 100 (40% MTD) or 200 ppm (80% MTD) diallyl disulfide suppressed only invasive adenocarcinomas of the colon. Although diets containing N-acetylcysteine and taurine inhibited colon tumor multiplicity, the effect was somewhat marginal. GST, NAD-(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase activities in colonic mucosa and tumor and liver were significantly elevated in animals fed anethole trithione or diallyl disulfide, compared to those fed the control diet. N-Acetylcysteine and taurine slightly but significantly increased only the GST activity in the liver. Although other mechanisms are not excluded, inhibition of AOM-induced colon carcinogenesis by anethole trithione and diallyl disulfide may be associated, in part, with increased activities of phase II enzymes such as GST, NAD(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase in the liver and colon. (+info)
Essential Oil Component Spotlight: (E)-Anethole - Be Kind Botanicals, Inc.
Fennel & Other Essential Oils with (E)-anethole
Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell...
E)-anethole - Registration Dossier - ECHA
Theoretical Spectroscopy Group
Medical Advisor Journals, Kyle J. Norton Site, Health Tips for Better Living and Living Health: Popular #Herbs - Anise
Revulsan, camphor racemic, lavender oil, anethole, peppermint oi, eucalyptol, clove oil, cinnamon oil
Para-Methoxyamphetamine - Wikipedia
E)-anethole - Registration Dossier - ECHA
Subepithelial vascular patterns in bronchial dysplasias using a high magnification bronchovideoscope | Thorax
Oltipraz - Wikipedia
Aromatherapy References | Terpenes
Aromatherapy References | Terpenes
Turpentine, oil - Registration Dossier - ECHA
Turpentine, oil - Registration Dossier - ECHA
Green Tea Extract in Treating Current or Former Smokers With Bronchial Dysplasia
Sante - Tabac, drogue, alcohol
Budesonide in Treating Former and Current Smokers With Bronchial Dysplasia - Full Text View - ClinicalTrials.gov
How bad is it to take advil or tylenol for a hangover - Things You Didnt Know
illicium anisatum l [Tinkturenpresse]
chamomile Archives - Healed with Herbs
Persian Basil Seedling | So Delish
Fit & Happier
Bronchial rupture - Buy cheap bronchial
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Discount Anise Vitamins & Supplements | Piping Rock Health Products
Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: Effect of chemical...
Harvest Market - Roasted Fennel with Parmesan
Orbit Foundation Basic Chemistry Model Set w/ Orbitals
Diffusion Science radio: Search Results
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Reasons to include Organic fennel in your diet - The Organic Food Blog
Kitchen Witchcraft: Star anise (illicium verum)
Determination of Seven Organosulfur Compounds in Garlic by High-Performance Liquid Chromatography
Watch The Pit and the Pendulum (2009) Online - SolarMovie
Garlic | ENCOGNITIVE.COM
Isethionic acid (2-Hydroxyethanesulfonic acid) | Organosulfur Compound | MedChemExpress
Using Fennel to Treat Infant Colic - Sergei Shushunov MD Herbal treatment of Infant Colic, Ear Infection, Fever, ADD,...
Patente US6465578 - Low compression, resilient golf balls including an organosulfur catalyst and ... - Google Patentes
Defy Aging with AGE...
Plus it
Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy | SpringerLink
Disulphide | Article about Disulphide by The Free Dictionary
Difference between revisions of User:Torsten Waldminghaus - OpenWetWare
MULTILAYER GOLF BALL - Patent application
Fennel - Rhythm of Healing | Massage | Ayurveda | Yoga
Korean BBQ Archives - Page 2 of 7 - Old Village Korean BBQ
23 Health Benefits of Diallyl disulfide and tirsulfide - Health Articles
ATC code A16
A16AX02 Anethole trithione. A16AX03 Sodium phenylbutyrate. A16AX04 Nitisinone. A16AX05 Zinc acetate. A16AX06 Miglustat. A16AX07 ...
Acetanisole
Sulfarlem (Anethole trithione) for treating Parkinson's disease. At room temperature 4-Methoxyacetophenone is solid, and has a ...
Self-microemulsifying drug delivery system
Jing Q; Shen Y; Ren F; Chen J; Jiang Z; Peng B; Leng Y; Dong J (November 2006). "HPLC determination of anethole trithione and ... SMEDDS in research or development include formulations of the drugs anethole trithione, oridonin, curcumin, vinpocetine, ... It employs the familiar ouzo effect displayed by anethole in many anise-flavored liquors. Microemulsions have significant ...
Anethole
See also thujone, anethole dithione (ADT), and anethole trithione (ATT).) Anethole has estrogenic activity. It has been found ... In the USA, anethole is generally recognized as safe (GRAS). After a hiatus due to safety concerns, anethole was reaffirmed by ... Most anethole is obtained from turpentine-like extracts from trees. Of only minor commercial significance, anethole can also be ... Fennel, which contains anethole, has been found to have a galactagogue effect in animals. Anethole bears a structural ...
Anethole trithione
... , anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. It is listed in ... Anethole trithione is an organosulfur compound, specifically, a dithiole-thione derivative. Felviten Halpen Hepasulfol - Franco ... EG Labo Tiopropen Tiotrifar Anethole Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. Retrieved ...
Anethole trithione - Wikipedia
Anethole trithione, anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. It is listed in ... Anethole trithione is an organosulfur compound, specifically, a dithiole-thione derivative. Felviten Halpen Hepasulfol - Franco ... EG Labo Tiopropen Tiotrifar Anethole Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. Retrieved ...
Anethole Trithione - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Get up-to-date information on Anethole Trithione side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more ... How was your experience with Anethole Trithione?. First, a little about yourself. Male Female ... How likely would you be to recommend Anethole Trithione to a friend?. ... This is not a complete list of Anethole Trithionedrug interactions. Ask your doctor or pharmacist for more information. ...
Global and Chinese Anethol Trithione Industry, 2017 Market Research Report, Trends, Share, Size Research Report
Global and Chinese Anethol Trithione Industry, 2017 Market Research Report Size and Share Published in 2017-06-01 Available for ... 8.3 Effects to Anethol Trithione Industry. Chapter Nine Market Dynamics of Anethol Trithione Industry. 9.1 Anethol Trithione ... 1.1 Brief Introduction of Anethol Trithione. 1.2 Development of Anethol Trithione Industry. 1.3 Status of Anethol Trithione ... Figure Manufacturing Process of Anethol Trithione. Table Trends of Anethol Trithione Manufacturing Technology. Figure Anethol ...
Anethol Trithione GMP Factory, Oxycodone Hydrochloride GMP Factaraidh - NFC
ATC code A16 - Wikipedia
Characters counted between 500 and 8000
China (Mainland)
Breast Mask
Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell...
Acetanisole - Wikipedia
Self-microemulsifying drug delivery system - Wikipedia
SMEDDS in research or development include formulations of the drugs anethole trithione,[2] oridonin,[3][4][5] curcumin,[6] ... Jing Q; Shen Y; Ren F; Chen J; Jiang Z; Peng B; Leng Y; Dong J (November 2006). "HPLC determination of anethole trithione and ... It employs the familiar ouzo effect displayed by anethole in many anise-flavored liquors. Microemulsions have significant ...
Pro Concepta Zug products
Technilab Pharma products
Xerostomia induced by radiotherapy: an overview of the physiopathology | TCRM
Another medication is anethole trithione that is a bile secretion-stimulating drug, or cholagogue. It increases the secretion ... In one randomized, double-blind, crossover study, the effect of this medication was compared to that of anethole trithione in ... Treatment of xerostomia with the bile secretion-stimulant drug anethole trithione: a clinical trial. Am J Med Sci. 1999;318:146 ... Abbreviations: EC, ethylenedicysteine; ECD, N,N′-1,2-ethylenediylbis-L-cysteinediethylester; AT, anethole trithione; QLQ, ...
KEGG BRITE: Anatomical Therapeutic Chemical (ATC) Classification
Fight Aging! Newsletter, May 20th 2019 - BioscienceNews - LONGECITY
A Nursing Perspective on Radiation-Induced Xerostomia | Cancer Network
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Minari extract for preventing the induction and metastasis of cancer by carcinogens contained in cigarette smoke, fermented...
Global and United States Liver and Gallbladder disease drugs In-Depth Research Report 2017-2022, Trends, Share, Size Research...
Table Top Brands of Anethol Trithione Liver and Gallbladder disease drugs Products List. Figure Global Anethol Trithione Liver ... Table Top Brands of Anethol Trithione Liver and Gallbladder disease drugs Products List. Figure United States Anethol Trithione ... 1.2.6 Anethol Trithione. 1.3 Liver and Gallbladder disease drugs, by Drugs of Anti-hepatitis and pr 2012-2022. 1.3.1 Global ... 2.2.6 Anethol Trithione. 2.3 Liver and Gallbladder disease drugs, by Drugs of Anti-hepatitis and pr 2012-2022. 2.3.1 United ...
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Caries Prevention for Patients with Dry Mouth | jcda
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Find Research Outputs
- Okayama University
Sialor2
- Sialor is also known as Anethole Trithione - non Rx. (mapleleafmeds.com)
- Sialogogues such as Pilocarpine (Salagen), Cevimeline (Evoxac), Bethanechol (Urecholine), Anethole Trithione (Sialor) and sugar-free gum and candies may also help. (oasisdiscussions.ca)
Sulfarlem2
- Sanofi-Aventis Sulfarlem S - EG Labo Tiopropen Tiotrifar Anethole Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. (wikipedia.org)
- Sulfarlem (Anethole trithione) for treating Parkinson's disease. (wikipedia.org)
Dithiolethione2
- Jore, D. Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione. (okuk.info)
- ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfid. (targetmol.com)
Anetholtrithion1
- Anethole trithione, anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. (wikipedia.org)
Derivative1
- Anethole trithione is an organosulfur compound, specifically, a dithiole-thione derivative. (wikipedia.org)
Cell3
- Anethole suppressed cell survival and induced apoptosis in human breast cancer cells independent of estrogen receptor status. (thefreedictionary.com)
- Anethole induces apoptotic cell death accompanies by reactive oxygen species production and DNA fragmentation in Aspergillus fumigatus and Saccharomyces cerevisiae. (thefreedictionary.com)
- The key aromatic compound in star anise anethole has demonstrated both anti and pro-cancerous effects depending on the estrogen receptor statuses in individual cell lines. (thefreedictionary.com)
Market5
- The 'Global and Chinese Anethol Trithione Industry, 2012-2022 Market Research Report' is a professional and in-depth study on the current state of the global Anethol Trithione industry with a focus on the Chinese market. (researchmoz.us)
- The report provides key statistics on the market status of the Anethol Trithione manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. (researchmoz.us)
- Through the statistical analysis, the report depicts the global and Chinese total market of Anethol Trithione industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. (researchmoz.us)
- The report then estimates 2017-2022 market development trends of Anethol Trithione industry. (researchmoz.us)
- 5.2 Market Competition of Anethol Trithione Industry by Country (USA, EU, Japan, Chinese etc. (researchmoz.us)
Important3
- In the end, the report makes some important proposals for a new project of Anethol Trithione Industry before evaluating its feasibility. (researchmoz.us)
- Overall, the report provides an in-depth insight of 2012-2022 global and Chinese Anethol Trithione industry covering all important parameters. (researchmoz.us)
- The essence or volatile oil of the Fennel is a yellow liquid which is made by distillation of its fruit by steam, the most important components of which are Anethole , Fenchone, Esteragole, alkalis [24]. (thefreedictionary.com)
Potential1
- Kubo, I. Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent. (okuk.info)