Choleretic used to allay dry mouth and constipation due to tranquilizers.
A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.
Substances added to foods and medicine to improve the quality of taste.
A plant genus in the family APIACEAE (Umbelliferae) that is used in SPICES and is a source of anethole.

Usefulness of basal and pilocarpine-stimulated salivary flow in primary Sjogren's syndrome. Correlation with clinical, immunological and histological features. (1/6)

OBJECTIVES: To examine salivary function in patients with primary Sjogren's syndrome (SS) by assessing unstimulated and stimulated flows using 5 mg of pilocarpine in a 5% solution, in order to define their clinical usefulness in the evaluation of xerostomia in patients with primary SS as well as to identify those factors related to the increase in salivary flow after pilocarpine stimulation. METHODS: We investigated the clinical and immunological characteristics of 60 consecutive patients with primary SS. All patients fulfilled four or more of the preliminary diagnostic European criteria for SS. We measured unstimulated (basal) salivary flow (BSF) in all patients. In patients with BSF +info)

A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia. (2/6)

BACKGROUND: Results from preclinical studies have suggested that the organosulfur compound anethole dithiolethione (ADT) may be an effective chemopreventive agent for lung cancer. We conducted a phase IIb study to determine the effects of ADT in smokers with bronchial dysplasia. METHODS: One hundred twelve current and former smokers with a smoking history of at least 30 pack-years and at least one site of bronchial dysplasia identified by an autofluorescence bronchoscopy-directed biopsy were randomly assigned to receive placebo or ADT at 25 mg orally thrice daily for 6 months. Each subject then underwent a follow-up bronchoscopy-directed biopsy. We used changes in histopathologic grade and nuclear morphometry index (MI) as the primary and secondary end point biomarkers, respectively. Chi-square tests with continuity correction were used to compare response rates on a lesion- and person-specific basis between the two study groups. All statistical tests were two-sided. RESULTS: One hundred one subjects had a follow-up bronchoscopy. In the lesion-specific analysis, progression rate of pre-existing dysplastic lesions by two or more grades and/or the appearance of new lesions was statistically significantly lower in the ADT group (8%) than in the placebo group (17%) (P<.001; difference = 9%, 95% confidence interval [CI] = 4% to 15%). In the person-specific analysis, the disease progression rate was statistically significantly lower in the ADT group (32%) than in the placebo group (59%) (P =.013; difference = 27%, 95% CI = 6% to 48%). The two treatment groups did not differ statistically significantly in terms of nuclear MI. Among individuals with an abnormal nuclear MI before treatment (29 in the ADT group and 25 in the placebo group), the progression rate in the ADT group (41%) was substantially lower than that in the placebo group (60%), although the difference was not statistically significant (P =.28; difference = 19%, 95% CI = -11% to 49%). Adverse events were mostly minor gastrointestinal symptoms that resolved with dose reduction or discontinuation of the medication. CONCLUSION: Our results suggest that, in smokers, ADT is a potentially efficacious chemoprevention agent for lung cancer.  (+info)

Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid. (3/6)

BACKGROUND AND PURPOSE: Angiogenesis involves multiple signaling pathways that must be considered when developing agents to modulate pathological angiogenesis. Because both cyclooxygenase inhibitors and dithioles have demonstrated anti-angiogenic properties, we investigated the activities of a new class of anti-inflammatory drugs containing dithiolethione moieties (S-NSAIDs) and S-valproate. EXPERIMENTAL APPROACH: Anti-angiogenic activities of S-NSAIDS, S-valproate, and the respective parent compounds were assessed using umbilical vein endothelial cells, muscle and tumor tissue explant angiogenesis assays, and developmental angiogenesis in Fli:EGFP transgenic zebrafish embryos. KEY RESULTS: Dithiolethione derivatives of diclofenac, valproate, and sulindac inhibited endothelial cell proliferation and induced Ser(78) phosphorylation of hsp27, a known molecular target of anti-angiogenic signaling. The parent drugs lacked this activity, but dithiolethiones were active at comparable concentrations. Although dithiolethiones can potentially release hydrogen sulphide, NaSH did not reproduce some activities of the S-NSAIDs, indicating that the dithioles regulate angiogenesis through mechanisms other than release of H(2)S. In contrast to the parent drugs, S-NSAIDs, S-valproate, NaSH, and dithiolethiones were potent inhibitors of angiogenic responses in muscle and HT29 tumor explants assessed by 3-dimensional collagen matrix assays. Dithiolethiones and valproic acid were also potent inhibitors of developmental angiogenesis in zebrafish embryos, but the S-NSAIDs, remarkably, lacked this activity. CONCLUSIONS AND IMPLICATION: S-NSAIDs and S-valproate have potent anti-angiogenic activities mediated by their dithiole moieties. The novel properties of S-NSAIDs and S-valproate to inhibit pathological versus developmental angiogenesis suggest that these agents may have a role in cancer treatment.  (+info)

Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. (4/6)

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Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent. (5/6)

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Chemoprevention of colon carcinogenesis by organosulfur compounds. (6/6)

It has been reported that several naturally occurring and related synthetic organosulfur compounds exert chemopreventive effects in several target organs in rodent models. The chemopreventive actions of 40 and 80% maximum tolerated doses (MTD) of organosulfur compounds, namely anethole trithione, diallyl disulfide, N-acetylcysteine, and taurine, administered in AIN-76A diet, on azoxymethane (AOM)-induced neoplasia were investigated in male F344 rats. Also, the effects of these agents on the activities of phase II enzymes, namely glutathione S-transferase (GST), NAD(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase, in the liver and colonic mucosa and tumors were assessed. The MTD levels of anethole trithione, diallyl disulfide, N-acetylcysteine, and taurine were determined in male F344 rats and found to be 250, 250, 1500, and 1500 ppm, respectively. At 5 weeks of age, animals were fed the control diet (AIN-76A) or experimental diets containing 40 or 80% MTD levels of each test agent. All animals in each group, except those allotted for vehicle (saline) treatment, were administered AOM s.c. at a dose rate of 15 mg/kg body weight once weekly for 2 weeks. All animals were necropsied during week 52 after the second AOM injection. Colonic mucosal and tumor and liver enzyme activities were measured in animals fed 80% MTD levels of each test agent. Colon tumors were subjected to histopathological evaluation and classified as invasive or noninvasive adenocarcinomas. Colon tumor incidence (percentage of animals with tumors) and tumor multiplicity (tumors/animal) were compared among various dietary groups. The results indicated that administration of 200 ppm (80% MTD) anethole trithione significantly inhibited the incidence and multiplicity of both invasive and noninvasive adenocarcinomas, whereas feeding of 100 ppm (40% MTD) anethole trithione or 100 (40% MTD) or 200 ppm (80% MTD) diallyl disulfide suppressed only invasive adenocarcinomas of the colon. Although diets containing N-acetylcysteine and taurine inhibited colon tumor multiplicity, the effect was somewhat marginal. GST, NAD-(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase activities in colonic mucosa and tumor and liver were significantly elevated in animals fed anethole trithione or diallyl disulfide, compared to those fed the control diet. N-Acetylcysteine and taurine slightly but significantly increased only the GST activity in the liver. Although other mechanisms are not excluded, inhibition of AOM-induced colon carcinogenesis by anethole trithione and diallyl disulfide may be associated, in part, with increased activities of phase II enzymes such as GST, NAD(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase in the liver and colon.  (+info)

Anethole trithione is not a medical term, but a chemical compound. It's a synthetic compound that has been used in the past as a medication to treat certain types of cancer, specifically germ cell tumors and ovarian cancer. However, its use in medicine is no longer common due to the development of other more effective and less toxic treatments.

Anethole trithione works by damaging the DNA of cancer cells, which can lead to their death. It was often used in combination with other chemotherapy drugs to increase its effectiveness.

It's important to note that anethole trithione is not approved for use in many countries and should only be administered under the supervision of a qualified healthcare professional.

Anisoles are organic compounds that consist of a phenyl ring (a benzene ring with a hydroxyl group replaced by a hydrogen atom) attached to a methoxy group (-O-CH3). The molecular formula for anisole is C6H5OCH3. Anisoles are aromatic ethers and can be found in various natural sources, including anise plants and some essential oils. They have a wide range of applications, including as solvents, flavoring agents, and intermediates in the synthesis of other chemicals.

Flavoring agents are substances added to foods, beverages, pharmaceuticals, and sometimes even medical devices to enhance or modify their taste and aroma. They can be natural, derived from plants or animals, or synthetic, created in a laboratory. Flavoring agents do not necessarily provide any nutritional value and are typically used in small quantities.

In a medical context, flavoring agents may be added to medications to improve patient compliance, especially for children or individuals who have difficulty swallowing pills. These agents can help mask the unpleasant taste of certain medicines, making them more palatable and easier to consume. However, it is essential to ensure that the use of flavoring agents does not interfere with the medication's effectiveness or safety.

"Pimpinella" is a term that refers to a genus of plants in the family Apiaceae, also known as the carrot or parsley family. The most common species in this genus is Pimpinella anisum, which is known as anise or aniseed. This herb is native to the eastern Mediterranean region and Southwest Asia, and its seeds are used as a spice and medicinal plant.

Aniseed has been used in traditional medicine for various purposes, including treating digestive disorders such as bloating, gas, and indigestion. It contains a compound called anethole, which has been found to have antispasmodic, carminative, and analgesic properties. However, it's important to note that while aniseed may have some health benefits, it should not be used as a substitute for professional medical advice or treatment.

Therefore, "Pimpinella" is not a medical term per se but rather a botanical name for a genus of plants with potential medicinal uses.

... , anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. It is listed in ... Anethole trithione is an organosulfur compound, specifically, a dithiole-thione derivative. Felviten Halpen Hepasulfol - Franco ... Christen MO (1995). Anethole dithiolethione: biochemical considerations. Methods in Enzymology. Vol. 252. pp. 316-23. doi: ... EG Labo Tiopropen Tiotrifar Anethole Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. Retrieved ...
See also thujone, anethole dithione (ADT), and anethole trithione (ATT).) Anethole has estrogenic activity. It has been found ... In the USA, anethole is generally recognized as safe (GRAS). After a hiatus due to safety concerns, anethole was reaffirmed by ... Most anethole is obtained from turpentine-like extracts from trees. Of only minor commercial significance, anethole can also be ... Fennel, which contains anethole, has been found to have a galactagogue effect in animals. Anethole bears a structural ...
Jing Q; Shen Y; Ren F; Chen J; Jiang Z; Peng B; Leng Y; Dong J (November 2006). "HPLC determination of anethole trithione and ... SMEDDS in research or development include formulations of the drugs anethole trithione, oridonin, curcumin, vinpocetine, ... It employs the familiar ouzo effect displayed by anethole in many anise-flavored liquors. Microemulsions have significant ...
... anethole trithione MeSH D02.355.601.200.324 - butylated hydroxyanisole MeSH D02.355.601.250 - bis(chloromethyl) ether MeSH ... anethole trithione MeSH D02.355.726.158.324 - butylated hydroxyanisole MeSH D02.355.726.453 - guaiacol MeSH D02.355.726.453.400 ... anethole trithione MeSH D02.755.075.241 - butylated hydroxyanisole MeSH D02.755.075.536 - guaiacol MeSH D02.755.075.536.400 - ...
A16AB23 Cipaglucosidase alfa A16AB24 Pegzilarginase A16AB25 Olipudase alfa A16AX01 Thioctic acid A16AX02 Anethole trithione ...
Anethole trithione, anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. It is listed in ... Anethole trithione is an organosulfur compound, specifically, a dithiole-thione derivative. Felviten Halpen Hepasulfol - Franco ... Christen MO (1995). Anethole dithiolethione: biochemical considerations. Methods in Enzymology. Vol. 252. pp. 316-23. doi: ... EG Labo Tiopropen Tiotrifar Anethole Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. Retrieved ...
trans-Anethole 4180-23-8 C10H12O Anethole trithione 532-11-6 C10H8OS3 ...
Administration of organosulfur compounds such as diallyl sulfide,oltipraz, or anethole trithione during the initiation and/or ... and their substituted and synthetic analogues tested for their efficacy in our animal model assay included anethole trithione, ...
Sulfarlem is a drug containing a chemical called Anethole trithione. Anethole is an organic compound used as a flavouring, it ... Sulfarlem / Anethole trithione (AOL) for Autism secondary to Mitochondrial Dysfunction (AMD)? Not to mention Metastasis ... In one embodiment, said inhibitor is anethole trithione (AOL). In one embodiment, said inhibitor inhibits mitochondrial ... Anethole trithione and it is used to treat people with a dry mouth, mainly in French speaking countries (including Canada) and ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
Anethole Trithione D2.886.753.77. Angina Pectoris C14.280.647.250.125 C14.280.647.187. C14.907.553.470.250.125 C14.907.585.187 ...
This Anethole trithione was achieved by the synchronous electro-transfer of two DNA plasmids, a SB transposon (CD19RCD28) and a ... Carl June (University or college of Pennsylvania) for help generating and providing aAPC clone #4 and Anethole trithione Dr. ... To generate clinically-sufficient numbers of genetically altered T cells we use K562-derived artificial Anethole trithione ... Thomas Scott; National Foundation for Malignancy Anethole trithione Research; Pediatric Malignancy Research Foundation; ...
... anethole trithione (ADT), and a macrophage membrane. Co-MOF degradation in the tumour microenvironment releases Co2+, which ...
Anethole Trithione. *Dicyclomine Hcl…. *Methscopolamine Methylsulfate. *Omeprazole Sod.. *Mebeverine Hcl. *Belladonna Extract… ...
Anethole trithione schlippes sale ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE 4,4-Thiobis(6-tert-butyl-m- ...

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  • Anethole trithione, anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. (wikipedia.org)
  • The drug is Sulfarlem / Anethole trithione and it is used to treat people with a dry mouth, mainly in French speaking countries (including Canada) and in China, particularly Taiwan. (epiphanyasd.com)
  • Anethole trithione, anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. (wikipedia.org)
  • Sanofi-Aventis Sulfarlem S - EG Labo Tiopropen Tiotrifar Anethole Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. (wikipedia.org)