Anesthetics
Anesthetics, Local
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Anesthetics, Inhalation
Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)
Anesthetics, General
Agents that induce various degrees of analgesia; depression of consciousness, circulation, and respiration; relaxation of skeletal muscle; reduction of reflex activity; and amnesia. There are two types of general anesthetics, inhalation and intravenous. With either type, the arterial concentration of drug required to induce anesthesia varies with the condition of the patient, the desired depth of anesthesia, and the concomitant use of other drugs. (From AMA Drug Evaluations Annual, 1994, p.173)
Anesthetics, Intravenous
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
Isoflurane
Halothane
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Anesthetics, Combined
Enflurane
Lidocaine
Anesthesia
Anesthetics, Dissociative
Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed)
Propofol
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Anesthesia, Local
Methoxyflurane
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
Anesthesia, General
Anesthesia, Inhalation
Benzocaine
Ketamine
Nitrous Oxide
Nerve Block
Prilocaine
Thiopental
Etomidate
Procaine
Ether
Pentobarbital
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Dibucaine
Mepivacaine
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Anesthesia, Intravenous
Chloroform
Anesthesia, Conduction
Adjuvants, Anesthesia
Xylazine
Anesthesia Recovery Period
Anesthesia, Obstetrical
Hypnosis, Anesthetic
Fentanyl
Pregnanediones
Xenon
Dose-Response Relationship, Drug
Chlorofluorocarbons
Medetomidine
Monitoring, Intraoperative
Hypnotics and Sedatives
Anesthesia Department, Hospital
Ambulatory Surgical Procedures
Preanesthetic Medication
Amides
Receptors, GABA-A
Mandibular Nerve
Volatilization
Chloralose
Midazolam
A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
Barbiturates
Pain Measurement
Urethane
Zolazepam
1-Octanol
Consciousness Monitors
Alfaxalone Alfadolone Mixture
Conscious Sedation
Intubation, Intratracheal
Malignant Hyperthermia
Drug Interactions
Brachial Plexus
The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.
Dental Pulp Test
Electroencephalography
Rats, Sprague-Dawley
Analgesia, Epidural
Analgesics, Opioid
Intraoperative Complications
Sufentanil
Sodium Channels
Hemodynamics
Sciatic Nerve
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Double-Blind Method
Depression, Chemical
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
Dexmedetomidine
Felypressin
Analgesia, Obstetrical
Dogs
Epinephrine
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Ligand-Gated Ion Channels
Xenopus laevis
Potassium Channels, Tandem Pore Domain
Propanidid
Alcohols
Injections, Epidural
Flurothyl
Maxillary Nerve
Apoferritins
The protein components of ferritins. Apoferritins are shell-like structures containing nanocavities and ferroxidase activities. Apoferritin shells are composed of 24 subunits, heteropolymers in vertebrates and homopolymers in bacteria. In vertebrates, there are two types of subunits, light chain and heavy chain. The heavy chain contains the ferroxidase activity.
Anesthesia, Closed-Circuit
Inhalation anesthesia where the gases exhaled by the patient are rebreathed as some carbon dioxide is simultaneously removed and anesthetic gas and oxygen are added so that no anesthetic escapes into the room. Closed-circuit anesthesia is used especially with explosive anesthetics to prevent fires where electrical sparking from instruments is possible.
Sodium Channel Blockers
Gas Scavengers
Electrophysiology
Receptors, Glycine
Ion Channel Gating
The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.
Alfentanil
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Surgical Procedures, Operative
Pain
Droperidol
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Aminobenzoates
Prospective Studies
Patch-Clamp Techniques
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Unconsciousness
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Euthanasia, Animal
Reflex
Postoperative Complications
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Thiamylal
Drug Hypersensitivity
Injections, Spinal
Diazepam
Ethyl Chloride
Laryngismus
Femoral Nerve
Butorphanol
Batrachotoxins
Surgical Procedures, Minor
Chlorofluorocarbons, Methane
Receptors, Nicotinic
One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.
Operating Room Technicians
Stereoisomerism
Postanesthesia Nursing
Carbon Dioxide
Benzyl Alcohol
Drug Combinations
Morphine
Potassium Channels
GABA Modulators
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Oocytes
Binding Sites
Neurons
Pulmonary Alveoli
Rats, Wistar
Ischemic Preconditioning, Myocardial
Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
Receptors, GABA
Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.
Intraoperative Awareness
Trichloroethanes
Chlorinated ethanes which are used extensively as industrial solvents. They have been utilized in numerous home-use products including spot remover preparations and inhalant decongestant sprays. These compounds cause central nervous system and cardiovascular depression and are hepatotoxic. Include 1,1,1- and 1,1,2-isomers.
Subarachnoid Space
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Synaptosomes
Neuromuscular Nondepolarizing Agents
Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
Autonomic Nerve Block
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Pancuronium
Infusion Pumps
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Meperidine
Analgesia, Patient-Controlled
Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).
Oxygen
Ion Channels
Effect of remifentanil on the auditory evoked response and haemodynamic changes after intubation and surgical incision. (1/302)
We have observed the effect of intubation and incision, as measured by the auditory evoked response (AER) and haemodynamic variables, in 12 patients undergoing hernia repair or varicose vein surgery who received remifentanil as part of either an inhaled anaesthetic technique using isoflurane or as part of a total i.v. technique using propofol. Anaesthesia was induced with remifentanil 1 microgram kg-1 and propofol, neuromuscular block was achieved with atracurium 0.6 mg kg-1 before intubation, and anaesthesia was maintained with a continuous infusion of remifentanil in combination with either a continuous infusion of propofol or inhaled isoflurane. The AER and haemodynamic variables were measured before and after intubation and incision. The effects of intubation and incision on the AER and haemodynamic variables were not significantly different between the remifentanil-propofol and remifentanil-isoflurane groups. However, the study had a low power for this comparison. When the data for the two anaesthetic combinations were pooled, the only significant effects were increases in diastolic arterial pressure and heart rate immediately after intubation; these were not seen 5 min after intubation. There were no cardiovascular responses to incision. There were no significant changes in the AER after intubation or incision. (+info)Concentration and second-gas effects in the water analogue. (2/302)
The water analogue provides a visual model of the process of anaesthetic exchange. In the standard version, a single pipe connects the mouth container to the lung container and the conductance of this mouth-lung pipe is proportional to alveolar ventilation. This implies that inspired and expired ventilations are equal. In fact, with high inspired concentrations of nitrous oxide, early rapid uptake of gas by solution leads to a substantial difference between inspired and expired ventilation which in turn leads to concentration and second-gas effects. It is shown that by representing inspired and expired ventilations separately, and keeping one of them constant while varying the other to compensate for rapid uptake, concentration and second-gas effects are reproduced in the water analogue. Other means of reproducing the effects are reported but we believe that the first method is the most realistic and the most appropriate for teaching. (+info)Recovery after halothane anaesthesia induced with thiopental, propofol-alfentanil or halothane for day-case adenoidectomy in small children. (3/302)
We studied recovery from halothane anaesthesia in 93 children, aged 1-3 yr, undergoing day-case adenoidectomy. Children were allocated randomly to receive thiopental 5 mg kg-1 (group TH), alfentanil 10 micrograms kg-1 and propofol 3 mg kg-1 (group PAH) or 5% halothane (group HH) for induction of anaesthesia. In group TH, tracheal intubation was facilitated with succinylcholine (suxamethonium) 1.5 mg kg-1. In groups PAH and HH, tracheal intubation was performed without neuromuscular block, and succinylcholine was used only if required. Anaesthesia was maintained with 1-3% halothane during spontaneous respiration. Times to achieving predetermined recovery end-points were recorded. Quality of recovery was assessed using a score of 1-9 (best to worst) for sedation, crying, restlessness and agitation. A postoperative questionnaire was used to determine the well-being of the child at home, 24 h after operation. Emergence from anaesthesia (response to non-painful stimuli) occurred earlier in group HH (mean 9 (SD 6) min) than in groups PAH (13 (6) min, P < 0.01) and TH (18 (14) min, P < 0.01). Sitting up, walking and home readiness were achieved earlier in groups PAH and HH than in group TH (P < 0.05 for each variable). Children in group TH were more sedated during the first 30 min after anaesthesia than those in the two other groups (P < 0.05) while emergence-related delirium was more common in group HH than in group TH (P < 0.01). Well-being at home was similar in all groups. We conclude that induction of halothane anaesthesia with propofol-alfentanil or halothane provided more rapid recovery and earlier discharge than that with thiopental. (+info)Haemodynamic stability and ketamine-alfentanil anaesthetic induction. (4/302)
We have determined if alfentanil could obtund the haemodynamic instability commonly seen at induction of anaesthesia with ketamine. Five groups of ASA I and II patients received ketamine 1 mg kg-1 i.v., preceded by saline (group 1) or alfentanil 10, 20, 30 or 40 micrograms kg-1 (groups 2-5, respectively). Heart rate (HR), mean arterial pressure (AP), postoperative patient complaints and dysphoria were noted. All groups showed increases (P < 0.05) in both HR and AP after administration of ketamine, which were progressively smaller as the dose of alfentanil increased. After tracheal intubation, all groups showed further increases in HR and AP, with groups 3-5 (alfentanil 20-40 micrograms kg-1) showing significant obtundation (P < 0.05) of these increases compared with group 1. No patient in any group reported postoperative dysphoria or dissatisfaction with their anaesthetic. Ketamine 1 mg kg-1 with alfentanil 20-40 micrograms kg-1 provided statistically significant obtundation of the haemodynamic instability that is common with ketamine alone. (+info)Comparison of recovery of propofol and methohexital sedation using an infusion pump. (5/302)
Two sedative anesthetic agents administered by an infusion pump were compared during third molar surgery. Forty American Society of Anesthesiologists (ASA) class I or II volunteers were randomly allocated to two groups. All subjects received supplemental oxygen via a nasal hood, fentanyl (0.0007 mg/kg intravenous [i.v.] bolus), and midazolam (1 mg/2 min) titrated to effect. Patients then received either 0.3 mg/kg of methohexital or 0.5 mg/kg of propofol via an infusion pump. Upon completion of the bolus, a continuous infusion of 0.05 mg/kg/min methohexital or 0.066 mg/kg/min propofol was administered throughout the procedure. Hemo-dynamic and respiratory parameters and psychomotor performance were compared for the two groups and no significant differences were found. The continuous infusion method maintained a steady level of sedation. Patients receiving propofol had a smoother sedation as judged by the surgeon and anesthetist. (+info)Bone marrow harvesting using EMLA (eutectic mixture of local anaesthetics) cream, local anaesthesia and patient-controlled analgesia with alfentanil. (6/302)
Bone marrow harvesting (BMH) was performed on 40 consecutive allogeneic or autologous donors using EMLA (eutectic mixture of local anaesthetics), local anaesthesia (LA) and patient-controlled analgesia with alfentanil (PCA-A). The effect of alkalinizing the LA solution on reducing pain during LA infiltration in the presence of EMLA was also investigated. EMLA 10 g with occlusive dressing was applied to the harvest sites at least 60 min before BMH. The PCA device was programmed to deliver an intravenous loading dose of 15 microg/kg alfentanil, followed by a background alfentanil infusion of 0.05 microg/kg/min. Demand dose was 4 microg/kg and lockout time was 3 min. Donors were randomized to receive either alkalinized (n = 19) or non-alkalinized (n=21) LA solution (lignocaine 1% with 1:100000 adrenaline). While post-operative nausea and vomiting were the only side-effects, all donors in both groups reported satisfactory pain scores during LA infiltration and satisfactory overall intra-operative comfort scores. They completed BMH using either regimen successfully, found this technique acceptable and would recommend this form of anaesthesia to others. Alkalinizing the LA solution did not significantly improve the pain scores during LA infiltration in the presence of EMLA. In conclusion, BMH can be performed safely using EMLA, LA and PCA-A without major complications. (+info)Effects of propofol, propofol-nitrous oxide and midazolam on cortical somatosensory evoked potentials during sufentanil anaesthesia for major spinal surgery. (7/302)
Recording of cortical somatosensory evoked potentials (CSEP) enables monitoring of spinal cord function. We studied the effects of propofol, propofol-nitrous oxide or midazolam during sufentanil anaesthesia on CSEP monitoring during major spinal surgery. Thirty patients with normal preoperative CSEP were allocated randomly to one of the following anaesthesia regimens: propofol (2.5 mg kg-1 followed by 10-6 mg kg-1 h-1) with or without nitrous oxide, or midazolam (0.3 mg kg-1 followed by 0.15 mg kg-1 h-1) combined with sufentanil 0.5 microgram kg-1 h-1 in the propofol and midazolam groups, or 0.25 microgram kg-1 h-1 in the propofol-nitrous oxide group. CSEP were elicited by alternate right and left tibial posterior nerve stimulation and recorded before and after induction (15 min, 1, 2 and 3 h), and during skin closure. CSEP latencies were not significantly modified in the three groups. CSEP amplitude decreased significantly in the propofol-nitrous oxide group (from mean 2.0 (SEM 0.3) to 0.6 (0.1) microV; P < 0.05) but not in the propofol (from 1.8 (0.6) to 2.2 (0.3) microV) or midazolam (1.7 (0.5) to 1.6 (0.5) microV) groups. The time to the first postoperative voluntary motor response (recovery) delay was significantly greater in the midazolam group (115 (19) min) compared with the propofol and propofol-nitrous oxide groups (43 (8) and 41 (3) min, respectively). Consequently, the use of propofol without nitrous oxide can be recommended during spinal surgery when CSEP monitoring is required. (+info)Anaesthetic effects of pregnanolone in combination with allopregnanolone, thiopental, hexobarbital and flurazepam: an EEG study in the rat. (8/302)
The anaesthetic interactions of the steroid, 3 alpha-hydroxy-5 beta-pregnan-20-one, in male rats were investigated in different fixed binary combinations with the steroid allopregnanolone (3 alpha-hydroxy-5 alpha-pregnan-20-one), two barbiturates (thiopental and hexobarbital) and the benzodiazepine, flurazepam. Anaesthetic effects were determined using an EEG threshold method. Interactions were assessed using an isobolographic method. The interaction between the two steroids, pregnanolone and allopregnanolone, showed an anaesthetic effect significantly less than additive (antagonistic). The interactions between pregnanolone and the two barbiturates and the benzodiazepine showed an anaesthetic effect significantly greater than additive (potentiation) in all tests performed. These results could be explained by a pharmacodynamic interaction at the hypothetical GABA-benzodiazepine-barbiturate-steroid complex in the CNS. (+info)
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... an anesthetic process that involves combining a major neuroleptic tranquilizer/antipsychotic with a potent opioid analgesic to ... Anesthetics Sedation Twilight sleep Moby's Medical Dictionary. Elsevier. Iorio, M. A.; Paszkowska Reymer, T.; Frigeni, V. (1987 ... Efforts were also made to develop compounds which combined both types of activity in a single molecule. Neuroleptanalgesia ... "Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds". Journal of Medicinal Chemistry. 30 (10): ...
Anterior cutaneous nerve entrapment syndrome
Treatment consists of several such anesthetic injections, sometimes combined with corticosteroids. Such an approach yields ... Confirmation of a diagnosis of ACNES is warranted using an abdominal wall infiltration with a local anesthetic agent near the ... This involves a repeated exploration combined with a posterior neurectomy. This procedure has been shown to be beneficial in 50 ...
Epinephrine (medication)
Epinephrine is frequently combined with local anesthetic and can cause panic attacks. Epinephrine is mixed with cocaine to form ... When epinephrine is mixed with local anesthetic, such as bupivacaine or lidocaine, and used for local anesthesia or intrathecal ... "Benefit and Harm of Adding Epinephrine to a Local Anesthetic for Neuraxial and Locoregional Anesthesia: A Meta-analysis of ... injection, it prolongs the numbing effect and motor block effect of the anesthetic by up to an hour. ...
Sudocrem
... and a weak anesthetic. As well as nappy rash, it can also be used to treat eczema, bedsores, minor burns, surface wounds, ... and combined with, Actavis plc. On March 17, 2015 (2015-03-17), Actavis completed the acquisition of Allergan, creating a $23 ...
Temporomandibular joint dysfunction
Injections of local anesthetic, sometimes combined with steroids, into the muscles (e.g. the temoralis muscle or its tendon) ... Local anesthetics may provide temporary pain relief, and steroids inhibit pro-inflammatory cytokines. Steroids and other ... This may occur during dental treatment, with oral intubation whilst under a general anesthetic, during singing or wind ...
Humphry Davy
Anesthetics were not regularly used in medicine or dentistry until decades after Davy's death. Davy threw himself energetically ... At one point the gas was combined with wine to judge its efficacy as a cure for hangover (his laboratory notebook indicated ... His respiration of nitric oxide which may have combined with air in the mouth to form nitric acid (HNO3), severely injured the ...
Liposuction
The lipedema fat is removed using a fan-shaped jet of water, which includes the anesthetic. In contrast to tumescent ... Note that techniques can be combined; for instance one could refer to the procedure as "lymph-sparing, tumescent liposuction ... Paik, AM; Daniali, LN; Lee, ES; Hsia, HC (2014). "Local anesthetic use in tumescent liposuction: an American Society of Plastic ... Lidocaine was also added as a local anesthetic. Fournier also advocated using compression after the operation, and travelled ...
Epidural administration
This is called combined spinal and epidural anesthesia (CSE). The spinal anesthetic may be administered in one location, and ... This may result in a high block, or, more rarely, a total spinal, where anesthetic is delivered directly to the brainstem, ... For some procedures where both the rapid onset of a spinal anesthetic and the post-operative analgesic effects of an epidural ... In addition to blocking nerves which carry pain signals, local anesthetics may block nerves which carry other signals, though ...
Ketamine
It suppresses breathing much less than most other available anesthetics. When used at anesthetic doses, ketamine usually ... Hence, it appears most conventional antidepressants can be safely combined with ketamine. Antagonism of the NMDA receptor is ... At lower sub-anesthetic doses, psychiatric side effects are prominent. A majority of patients feel strange, spacey, woozy or ... At lower, sub-anesthetic doses, ketamine is a promising agent for pain and treatment-resistant depression. However, the ...
Ether Dome
Previous anesthetic approaches had utilized alcohol or even a simple blow to the jaw that would render the patient unconscious ... All the above-mentioned features were combined with knowledge gained after practice using this inhaler-such as that the slot ... It was the site of the first public demonstration of the use of inhaled ether as a surgical anesthetic on October 16, 1846, ... When the condensation is mixed with the ether and is inhaled, it develops the chemical properties of an anesthetic. The hot- ...
Epidural (disambiguation)
The term is most commonly used to refer to epidural administration of analgesics and anesthetics. It may also refer to: ... Epidural blood patch Caudal epidural Combined spinal and epidural anaesthesia (CSE) Epidural steroid injection Patient- ...
Hypodermic needle
Topical anesthetics can be used to desensitize the area where the injection will take place to reduce pain and discomfort. For ... Techniques include: distraction, hypnosis, combined cognitive behavioral therapy, and breathing techniques. Cannula Catheter ...
Barbiturate
... anesthetic effect of barbiturates in high doses when used in anesthetic concentration. Barbituric acid was first synthesized ... The middle two classes of barbiturates are often combined under the title "short/intermediate-acting." These barbiturates are ... However, barbiturates are still used as anticonvulsants (e.g., phenobarbital and primidone) and general anesthetics (e.g., ... However, while GABAA receptor currents are increased by barbiturates (and other general anesthetics), ligand-gated ion channels ...
Intravenous regional anesthesia
The veins are filled with the anesthetic, with the anesthetic setting into local tissue after approximately 6-8 minutes, after ... as well as dual-bladder tourniquet cuffs combined with dedicated safety lockouts that reduce human error. Additionally, IVRA ... or Bier's block anesthesia is an anesthetic technique on the body's extremities where a local anesthetic is injected ... The type of anesthetic agent, improper equipment use or selection, and technical error are prominent factors in most cases of ...
Flunitrazepam
It has also been shown to have therapeutic use in polysubstance use when combined with anesthetics, opioids, ethanol, cocaine, ... Rohypnol lowers the side effects of the anesthetic (ketamine), resulting in less confusion in awakening states, less negative ...
William Gibson A. Bonwill
About his dental research a long list of inventions have made him famous among professionals of his time, such as combine ... It was published in 1875 under the title "The air an anesthetic" and presented at the Franklin Institute. Bonwill invented an ... The Bonwill Brace is a support bracket - by combining two brackets, which includes two adjacent teeth. Erich Göhler, Bonwill ...
Benzocaine
It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined ... Overapplication of oral anesthetics such as benzocaine can increase the risk of pulmonary aspiration by relaxing the gag-reflex ... Benzocaine, sold under the brand name Orajel amongst others, is an ester local anesthetic commonly used as a topical pain ... Demare, Patricia; Regla, Ignacio (2012). "Synthesis of Two Local Anesthetics from Toluene: An Organic Multistep Synthesis in a ...
Divinyl ether
Leake predicted that vinyl ether would combine the properties of two anesthetic agents, ethyl ether, and ethylene. As an ... Vinyl ether is a potent anesthetic giving it a large safety margin; the ratio of the anesthetic to lethal does for vinyl ether ... The anesthetic product was inhibited with .01% phenyl-α-napthylamine which gave it a faint violet fluorescence. Vinyl ether ... Anesthetic machines of the time could suitably contain vinyl ether's potency, however, via the open drop technique smooth ...
Mitragyna speciosa
The leaves or extracts from them are used to heal wounds and as a local anesthetic. Extracts and leaves have been used to treat ... The herb is bitter and is generally combined with a sweetener. As of 2018[update], there have been no formal trials to study ...
Cataract surgery
The steps may be described as follows: Anaesthesia; Topical anesthetic agents are most commonly used and may be placed on the ... The patients with retinal detachment may be scheduled for a combined vitreo-retinal procedure, along with PC-IOL implantation. ... Anesthetic injection techniques include sub-conjunctival injections and or injections posterior to the globe (retrobulbar block ... In cases of uncontrolled glaucoma, a combined cataract-glaucoma procedure (phaco-trabeculectomy) can be planned and performed. ...
Isoxsuprine
It should therefore be used with caution if combined with other drugs that affect blood pressure, such as sedatives and ... anesthetic drugs. Isoxsuprine is most commonly used to treat hoof-related problems in the horse, most commonly for laminitis ...
Neuromuscular blocking agents
Combining different NMBAs can result in different degrees of neuromuscular block and management should be guided with the use ... Inhaled anesthetics inhibit nicotinic acetylcholine receptors (nAChRs) and potentiate neuromuscular blockage with ... Combining two nondepolarising NMBAs of the same chemical class (e.g. rocuronium and vecuronium) produces an additive effect, ... It depends on the type of volatile anesthetic (desflurane > sevoflurane > isoflurane > nitrous oxide), the concentration and ...
Cocaine
If vasoconstriction is desired for a procedure (as it reduces bleeding), the anesthetic is combined with a vasoconstrictor such ... Benzoyl-CoA then combines the two units to form cocaine. The biosynthesis begins with L-Glutamine, which is derived to L- ... This, combined with crop reductions in Bolivia and Peru, made Colombia the nation with the largest area of coca under ... There is also evidence that these cultures used a mixture of coca leaves and saliva as an anesthetic for the performance of ...
Hua Tuo
The name mafeisan combines ma (麻; "cannabis; hemp; numbed"), fei (沸; "boiling; bubbling") and san (散; "break up; scatter; ... The Records of the Three Kingdoms and the Book of the Later Han both credit him as creating this anesthetic during the Eastern ... Hua Tuo was an older contemporary of the physician Zhang Zhongjing (150-219). The name Hua Tuo combines the Chinese surname Hua ... He used a general anaesthetic combining wine with a herbal concoction called mafeisan (麻沸散; literally "cannabis boil powder"). ...
Hydromorphone
When combined therapy is contemplated, the dose of one or both agents should be reduced. Hydromorphone is a semi-synthetic μ- ... CNS depressants may enhance the depressant effects of hydromorphone, such as other opioids, anesthetics, sedatives, hypnotics, ... Simultaneous use of hydromorphone with other opioids, muscle relaxants, tranquilizers, sedatives, and general anesthetics may ...
Toxopneustes pileolus
When combined together into the holoprotein peditoxin, even low doses resulted in anaphylaxis-like shock and death. UT841, a ... and anesthetic coma. At higher doses it resulted in convulsions and death. Pedin itself is non-toxic, but it magnifies the ...
List of medieval European scientists
John Arderne (1307-1392) was an English physician and surgeon who invented his own anesthetic that combined hemlock, henbane, ... He combined Platonic philosophy with Christian doctrine and initiated a renewal of Byzantine classical learning that later ...
Shoulder replacement
Currently, data on combined usage of general anesthesia and interscalene blocks are limited. Some indications for combined ... A mixture of short and long-acting local anesthetics is used to prolong the duration as well as reduce the onset of the nerve ... One example of a commonly used regional anesthetic is an interscalene brachial plexus block and it has been used in a number of ... The following anesthetics are methods commonly used to assist with post-operative shoulder replacement pain management: Three ...
Obstetric anesthesiology
Neuraxial (regional) anesthetic and analgesia techniques: (e.g. epidural, spinal, combined spinal-epidural) are used most ... Following Morton's use of ether as an anesthetic, James Simpson conducted his own obstetric anesthetic trial on January 19, ... The inhalation of anesthetic agents do not affect the act of labor or the mechanism by which uterine contractions occur, but ... With this finding, along with the statistical records of safely executed anesthetic administrations, the medical opposition to ...
Douglas W. Owsley
... and combined some of his chemicals with some of his mother's bathroom cleaning solutions and developed an anesthetic. Testing ...
Alternative medicine
Some herbal remedies can cause dangerous interactions with chemotherapy drugs, radiation therapy, or anesthetics during surgery ... of extravagant claims by the alternative medical community combined with inadequate media scrutiny and attacks on critics.[122] ...
Chiropractic
"Combined chiropractic interventions for low-back pain". Cochrane Database of Systematic Reviews (4): CD005427. doi:10.1002/ ... involves sedation or local anesthetic and is done by a team that includes an anesthesiologist; a 2008 systematic review did not ... who attempt to combine the materialistic reductionism of science with the metaphysics of their predecessors and with the ... Chiropractic combines aspects from mainstream and alternative medicine, and there is no agreement about how to define the ...
GABAA receptor positive allosteric modulator
Selye H (1 January 1941). "Anesthetic Effect of Steroid Hormones". Experimental Biology and Medicine. 46 (1): 116-121. doi: ... Barbiturates were synthesized in 1864 by Adolf von Baeyer by combining urea and malonic acid (Figure 5). A synthesis process ... Although barbiturates fell out of favor, they continue to serve as a short-acting anesthetic and anti-epileptic drugs. ... Fig 2. Schematic diagram of a GABAA receptor protein ((α1)2(β2)2(γ2)) which illustrates the five combined subunits that form ...
Medical simulation
Combined with methods in debriefing, it is now also used to train students in anatomy, physiology, and communication during ... isoflurane and other anesthetic gases. PediaSIM HPS also responds to drug administration with a unique Drug Recognition System ... By combining these systems together, trainees can be contained to their respective areas of study while also studying the ...
Intravenous regional anesthesia
The veins are filled with the anesthetic, with the anesthetic setting into local tissue after approximately 6-8 minutes, after ... as well as dual-bladder tourniquet cuffs combined with dedicated safety lockouts that reduce human error.[9] Additionally, IVRA ... or Bier's block anesthesia is an anesthetic technique on the body's extremities where a local anesthetic is injected ... Cardiotoxic local anesthetic agents like bupivacaine and etidocaine are strictly contraindicated.[1][2][7] ...
Acute inhalation injury
A recent study documented in the AANA Journal discussed the use of volatile anesthetic agents, such as sevoflurane, to be used ... Thermal injury combined with inhalation injury compromises pulmonary function, producing microvascular hyperpermeability that ... It has been established that combined burn and smoke inhalation injury impairs hypoxic pulmonary vasoconstriction (HPV), the ...
Obstructive sleep apnea
NREM stage 2 and REM, which combined are 70% of an average person's total sleep time, are more associated with mental recovery ... RFA is usually performed in an outpatient setting, using either local anesthetics or conscious sedation anesthesia, the ... In this chromosomal abnormality, several features combine to make the presence of obstructive sleep apnea more likely. The ...
Artificial cardiac pacemaker
Some combine a pacemaker and defibrillator in a single implantable device. Others have multiple electrodes stimulating ... A pacemaker is typically inserted into the patient through a simple surgery using either local anesthetic or a general ... Weirich WL, Gott VL, Lillehei CW (1957). "The treatment of complete heart block by the combined use of a myocardial electrode ... CRT can be combined with an implantable cardioverter-defibrillator (ICD): such devices, known as CRT-D (for defibrillation), ...
Kava
Alcohol: It has been reported that combined use of alcohol and kava extract can have additive sedative effects.[36][79] ... The root of the plant is used to produce a drink with sedative, anesthetic, and euphoriant properties. Its active ingredients ... The ground root/bark is combined with only a little water, as the fresh root releases moisture during grinding. Pounding is ...
User:The ed17/Archives/34
So you can see that the volatile anesthetic agents of today are really a spin-off of the technology developed during the ... The 2010 WikiCup is over! It has been a long journey, but what has been achieved is impressive: combined, participants have ... All of the currently used volatile anesthetic agents, including methoxyflurane, are fluorinated haloalkanes. With the exception ...
Controlled Substances Act
Cocaine: used as a topical anesthetic and to stop severe epistaxis. *Codeine (pure) and any drug for non-parenteral ... Paregoric, an antidiarrheal and anti-tussive, which contains opium combined with camphor (which makes it less addiction-prone ... The CSA not only combined existing federal drug laws and expanded their scope, but it also changed the nature of federal drug ... Ketamine, a drug originally developed as a safer, shorter-acting replacement for PCP (mainly for use as a human anesthetic) but ...
Duchenne de Boulogne
... partial and combined. To stimulate the facial muscles and capture these "idealized" expressions of his patients, Duchenne ... and furthermore said that because the patient was suffering from an anesthetic condition of the face, he could experiment upon ...
Lamotrigine
A combined study of open cases and a meta-analysis". Revista de Psiquiatria y Salud Mental. 6 (4): 144-9. doi:10.1016/j.rpsm. ... Local anesthetics (e.g., lidocaine). *Mexiletine. *TCAs (e.g., amitriptyline, nortriptyline, desipramine) ...
Ketorolac
"Patient considerations in cataract surgery - the role of combined therapy using phenylephrine and ketorolac". Patient ... Local anesthetics (e.g., cocaine, lidocaine). *Mexiletine. *Nefopam. *Tricyclic antidepressants (e.g., amitriptyline#) ...
Theanine
Owen, Gail N.; Parnell, Holly; De Bruin, Eveline A.; Rycroft, Jane A. (2008). "The combined effects of L-theanine and caffeine ...
ഓക്സൈഡ് - വിക്കിപീഡിയ
Laughing gas, anesthetic (used in a combination with diatomic oxygen (O2) to make Nitrous oxide and oxygen anesthesia), ... form when oxygen combines with other elements ...
Serotonin-norepinephrine reuptake inhibitor
Papakostas GI, Thase ME, Fava M, Nelson JC, Shelton RC (December 2007). "Are antidepressant drugs that combine serotonergic and ... Local anesthetics (e.g., lidocaine). *Mexiletine. *TCAs (e.g., amitriptyline, nortriptyline, desipramine) ... Papakostas GI, Thase ME, Fava M, Nelson JC, Shelton RC (December 2007). "Are antidepressant drugs that combine serotonergic and ... Several studies have shown that antidepressant drugs which have combined serotonergic and noradrenergic activity are generally ...
Analgesic
These topical anesthetics contain anesthetic drugs such as lidocaine, tetracaine, benzocaine, and prilocaine in a cream, ... Smith, Howard S.; Raffa, Robert B.; Pergolizzi, Joseph V.; Taylor, Robert; Tallarida, Ronald J. (2014-07-01). "Combining opioid ... Lidocaine, an anesthetic, and steroids may be injected into joints for longer-term pain relief. Lidocaine is also used for ... They are distinct from anesthetics, which temporarily affect, and in some instances completely eliminate, sensation. Analgesics ...
Neutering
In one study the risk of anesthetic-related death (not limited to neutering procedures) was estimated at 0.05% for healthy dogs ... However, the incidence of adverse reactions for neutered and intact dogs combined is only 0.32%.[48] ... As with any surgical procedure, immediate complications of neutering include the usual anesthetic and surgical complications, ...
Stimulant
... and cocaine combined[clarification needed] is between 0.8% and 2.1%.[4] ... nasal congestion and as anesthetics.[24] Drugs used to treat obesity are called anorectics and generally include drugs that ... although it sees clinical use as a local anesthetic, in particular in ophthalmology. Most cocaine use is recreational and its ...
NMDA receptor
Maher, T.J. (2013). Anesthetic agents: General and local anesthetics. In: T.L. Lemke & D.A. Williams (editors). Foye's ... Activation of NMDA receptors results in the opening of the ion channel that is nonselective to cations, with a combined ... Antagonists of the NMDA receptor are used as anesthetics for animals and sometimes humans, and are often used as recreational ... Motor Discoordination Results from Combined Gene Disruption of the NMDA Receptor NR2A and NR2C Subunits, But Not from Single ...
C. Everett Koop
These four issues combined with Koop's personality and his willingness to make use of mass media brought to the office of ... He invented anesthetic and surgical techniques for small bodies and metabolisms and participated in the separation of several ...
Jet injector
The J-Tip is being used as a prenumber for needle procedures by giving an anesthetic effect within 1-2 minutes. It is being ... Researchers developed a new jet injection design by combining the drug reservoir, plunger and nozzle into a single-use ...
اتیلن - ویکیپدیا، دانشنامهٔ آزاد
An example of a niche use is as an anesthetic agent (in an 85% ethylene/15% oxygen ratio).[15] It can also be used to hasten ... This group also discovered that ethylene could be combined with chlorine to produce the oil of the Dutch chemists, 1,2- ... ethylene was used as an anesthetic.[55][5] It remained in use through the 1940s use even while chloroform was being phased out ... "Advantages of Ethylene-Oxygen as an anesthetic". California and Western Medicine. 27 (2): 216-218. PMC 1655579. PMID 18740435 ...
Saline (medicine)
Water privation combined with diuretic block does not produce as much risk of CPM as saline administration does; however, it ... antibiotics or topical anesthetics. Eye drops sometimes do not have medications in them and are only lubricating and tear- ...
Chemotherapy
Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or ... Electrochemotherapy is the combined treatment in which injection of a chemotherapeutic drug is followed by application of high- ... In regard to the potential benefit that drug-resistant cells can be recruited for effective therapy by combining chemotherapy ... Anemia in cancer patients can be a combined outcome caused by myelosuppressive chemotherapy, and possible cancer-related causes ...
Epinephrine (medication)
Epinephrine/adrenaline is frequently combined with dental and spinal anesthetics and can cause panic attacks in susceptible ... Local anesthetics[edit]. Adrenaline is added to injectable forms of a number of local anesthetics, such as bupivacaine and ... Some of the adverse effects of local anesthetic use, such as apprehension, tachycardia, and tremor, may be caused by adrenaline ... Due to epinephrine's vasoconstricting abilities, the use of epinephrine in localized anesthetics also helps to diminish the ...
Sepsis
Requirements for anesthetics may be reduced in sepsis. Inhalational anesthetics can reduce the level of proinflammatory ... or broad-spectrum carbapenem combined with fluoroquinolones, macrolides, or aminoglycosides) are recommended. The choice of ... "Sepsis pathophysiology and anesthetic consideration". Cardiovascular & Hematological Disorders Drug Targets. 15 (1): 57-69. ... Usually, inhalational and intravenous anesthetics are used. ...
Rofecoxib
... and an 8-fold increase in heart attacks and strokes combined compared to both control groups.[15][37] Although this was a ... Local anesthetics (e.g., cocaine, lidocaine). *Mexiletine. *Nefopam. *Tricyclic antidepressants (e.g., amitriptyline#) ...
Aspirin
... , either by itself or in a combined formulation, effectively treats certain types of a headache, but its efficacy may be ... Local anesthetics (e.g., cocaine, lidocaine). *Mexiletine. *Nefopam. *Tricyclic antidepressants (e.g., amitriptyline#) ... aspirin is combined with an ADP receptor inhibitor, such as clopidogrel, prasugrel, or ticagrelor to prevent blood clots. This ... Combining aspirin with other NSAIDs has also been shown to further increase this risk.[94] Using aspirin in combination with ...
New Technique Combines Electrical Currents and Local Anesthetic for Pain Management
Combined electrochemical nerve block reduced pain in 80% of patients with neuropathies and 50% of patients with intractable ... New Technique Combines Electrical Currents and Local Anesthetic for Pain Management. As Originally published by Practical Pain ... In addition, we have combined the new EST with local anesthetic injections (bupivacaine 0.25%) with clinical success. This ... Combined electrochemical nerve block reduced pain in 80% of patients with neuropathies and 50% of patients with intractable ...
Perioperative anesthetic management of a combined right atrial thrombectomy with living donor liver transplantation
Patient underwent combined right atrial thrombectomy and living donor liver transplantation (LDLT) in the same setting. ... Perioperative anesthesia management and perioperative concerns of two major combined procedures are discussed.... ... Perioperative anesthetic management of a combined right atrial thrombectomy with living donor liver transplantation. *. ... Patient underwent combined right atrial thrombectomy and living donor liver transplantation (LDLT) in the same setting. ...
Vadi, M.G., Patel, N. and Stiegler, M.P. (2014) Local Anesthetic Systemic Toxicity after Combined Psoas Compartment-Sciatic...
Local Anesthetic Systemic Toxicity after Combined Psoas Compartment-Sciatic Nerve Block Analysis of Decision Factors and ... Vadi, M.G., Patel, N. and Stiegler, M.P. (2014) Local Anesthetic Systemic Toxicity after Combined Psoas Compartment-Sciatic ... Features and Principles the Spread of Local Anesthetic Blockade of the Sciatic Nerve at Depends on the Amount of Anesthetic ... Pressure of Local Anesthetic Solution While Performing Sciatic Nerve Blockade in Human Subgluteal Area ...
Novel anesthetic technique for combined intracavitary and interstitial brachytherapy for cervix cancer in an outpatient setting...
Purpose : To determine the feasibility and safety of outpatient combined intracavitary and interstitial brachytherapy for ... Novel anesthetic technique for combined intracavitary and interstitial brachytherapy for cervix cancer in an outpatient setting ... "Novel anesthetic technique for combined intracavitary and interstitial brachytherapy for cervix cancer in an outpatient setting ... "Novel anesthetic technique for combined intracavitary and interstitial brachytherapy for cervix cancer in an outpatient setting ...
Anesthetics, Combined | The Chopra Library
A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation - Full Text View -...
Anesthetics, Local. Anesthetics. Central Nervous System Depressants. Physiological Effects of Drugs. Sensory System Agents. ... A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation. This study has been ... Known drug sensitivity to amide-type local anesthetics. *Unlikely to understand or be able to comply with study procedures, for ... The study drug is a metered-dose anesthetic spray, which is being developed for the treatment of premature ejaculation (PE). ...
Local anesthetic - Wikipedia
LA drugs are also often combined with other agents such as opioids for synergistic analgesic action.[1] Low doses of LA drugs ... List of local anesthetics. References[edit]. *^ Ryan, T (2019). "Tramadol as an adjunct to intra‐articular local anaesthetic ... of Wisconsin, Local Anesthesia and Regional Anesthetics *^ a b Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik ... A local anesthetic (LA) is a medication that causes absence of pain sensation. When it is used on specific nerve pathways ( ...
DailyMed - Search Results for Amide Local Anesthetic
October 26, 1946 | Science News
Patent US5149320 - Composite anesthetic article and method of use - Google Patents
... wherein the anesthetic comprises from about 0.5 to about 2.0% by weight of the composition, the composition further containing ... the composition containing a local parenteral anesthetic which in normal doses gives an acid pH of from about 2.5 to about 6.9 ... An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the ... Combined mixing syringe and container. US3978212 *. Dec 13, 1974. Aug 31, 1976. Chemo Drug Company. Electrolyte solutions ...
Labor Epidural Analgesia to Cesarean Section Anesthetic Conversion Failure: A National Survey
... then a lower dose of intrathecal local anesthetic was selected and alternative options such as combined-spinal epidural and ... the most influential factors determining further anesthetic management were the category of cesarean section (92%), dermatomal ... factors influencing the management and selection of anesthetic technique. Differences in management options between respondents ... Further administration of local anesthetic can moreover increase the risk of local anesthetic systemic toxicity [18], a ...
10-HOUR OUTPATIENT PEDIATRIC ANESTHETICS FOR COMBINED ATRESIA-MICROTIA (CAM) EAR RECONSTRUCTION - The anesthesia consultant
Our anesthesia group routinely performs 10-hour outpatient pediatric anesthetics for combined atresia-microtia ear ... 3 thoughts on "10-HOUR OUTPATIENT PEDIATRIC ANESTHETICS FOR COMBINED ATRESIA-MICROTIA (CAM) EAR RECONSTRUCTION" * bank post ... The surgical-anesthetic team to date has successfully performed the combined procedure on 55 patients, 90% of who were of the ... This combined atresia and microtia repair, requiring a total anesthetic time approaching ten hours, is a new procedure being ...
Principles and Practice of Anesthesia for Thoracic Surgery | SpringerLink
The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain and Hemodynamic Changes Due to Propofol Injection - Full...
Anesthetics, Local. Anesthetics. Central Nervous System Depressants. Physiological Effects of Drugs. Sensory System Agents. ... Anesthetics, Intravenous. Anesthetics, General. Central Nervous System Stimulants. Sympathomimetics. Autonomic Agents. ... The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain and Hemodynamic Changes Due to Propofol Injection. This ... Title: The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain Due to Propofol Injection in Patients Undergoing ...
Medications for Pain Relief During Labor and Delivery
... analgesics and anesthetics, explains this ACOG patient FAQ. ... Anesthetics: Drugs that relieve pain by loss of sensation.. ... They include the epidural block, spinal block, and combined spinal-epidural (CSE) block. The medication includes an anesthetic ... Breathing problems if the anesthetic affects your breathing muscles. *Numbness, tingling, or rapid heartbeat if the anesthetic ... The anesthetic drug is injected into the area around the nerves that carry feeling to the vagina, vulva, and perineum. Local ...
Anesthetic | medicine | Britannica.com
Anesthetic, any agent that produces a local or general loss of sensation, including pain. Anesthetics achieve this effect by ... Not infrequently, general anesthetics are combined with drugs that block neuromuscular impulse transmission. These additional ... Anesthetic, also spelled anaesthetic, any agent that produces a local or general loss of sensation, including pain. Anesthetics ... General anesthetics. General anesthetics induce anesthesia throughout the body and can be administered either by inhalation or ...
Patent US4529601 - Local anesthetic mixture for topical application and method for obtaining ... - Google Patents
... especially local anesthetic preparations and deals with the problem of i a obtaining a solution of a local anesthetic agent in ... This problem has been dissolved according to the present invention thereby that one local anesthetic agent in the form of its ... is provided with one other local anesthetic agent in the form of its base and as such having a melting point of above 30 C., ... It is further known to combine two or more local anesthetics in the form of acid addition salts in aqueous solutions for ...
Epidural Anesthesia
Combined spinal/epidural block, Combined spinal/epidural local anaesthetic block, Combined spinal/epidural local anesthetic ... combined spinal epidural anesthesia, Combined spinal/epidural local anesthetic block (procedure). ... Uses a combined injection of spinal (intrathecal) and Epidural Anesthesia. *Lower dose anesthetic (bupivicaine or ropivicaine) ... Local anesthetic epidural block, Local anesthetic epidural block, Epidural anesthesia (procedure), Epidural Block. ...
Plus it
Anesthetic Profile of Dexmedetomidine Identified by Stimulus-Response and Continuous Measurements in Rats. Cornelis J. J. G. ... Combined with previous results (Bol et al., 1997a), the data suggest that the proposed EEG measure may better reflect different ... Anesthetic Profile of Dexmedetomidine Identified by Stimulus-Response and Continuous Measurements in Rats. Cornelis J. J. G. ... Anesthetic Profile of Dexmedetomidine Identified by Stimulus-Response and Continuous Measurements in Rats. Cornelis J. J. G. ...
Anesthetic management during the first combined heart-liver transplant performed in Korea: a case report
... Article information. ... Anesthetic management of combined heart-liver transplantation in a patient with ischemic cardiomyopathy and cardiac cirrhosis: ... Diaz GC, Renz JF, Nishanian E, Kinkhabwala M, Emond JC, Wagener G. Anesthetic management of combined heart-liver ... Herein, we describe the anesthetic management during the first combined heart-liver transplant (CHLT) performed in Korea. ...
What is Dent-O-Kain/20 used for? | Anesthetic Agent - Sharecare
Benzocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body. It is a topical gel ... A combined spinal-epidural block during labor and delivery has the benefits of pain relief from both... ... Anesthetic Agent. Anesthetic is a drug or substance that blocks pain and causes loss of feeling. Anesthetic drugs are used on ... Topical anesthetics are medications that help soothe itchy or irritated skin. They work by numbing t... ...
A comparison of a needle-free injection system for local anesthesia versus EMLA for intravenous catheter insertion in the...
J-Tip is a needle-less Food and Drug Administration approved injection system that can be used for delivery of local anesthetic ... Anesthetics, Combined / administration & dosage* * Anesthetics, Local / administration & dosage* * Catheterization, Peripheral ... J-Tip is a needle-less Food and Drug Administration approved injection system that can be used for delivery of local anesthetic ... In this study, we compared the effectiveness of J-Tip versus eutectic mixture of local anesthetics (EMLA) to facilitate IV ...
Lidocaine-prilocaine patch decreases the pain associated with the subcutaneous administration of measles-mumps-rubella vaccine...
Homemade topical anesthetic - What You Need to Know
Eastern on homemade topical anesthetic: Administration of topical anesthetics to control pain associated with procedures such ... Topical Fucidin cream combine with lightening cream is it safe? Dr. Joseph Eastern Dr. Eastern ... Anesthetic (Definition) Anestheticss are a class of drugs which cause a reversible loss of sensation. The 2 main classes are ... General anesthetics cause unconsciousness and total loss of sensation. Local anesthetics cause loss of sensation to a limited ...
Does local anesthetic dilution influence the clinical effectiveness of multiple-injection axillary brachial plexus block?: a...
Our aim was to test whether using 3 different volumes of the same local anesthetic dose i ... and concentration of local anesthetic and the quality and success of regional anesthesia remains unclear. ... 19263066 - Preoperative intravenous dexamethasone combined with glossopharyngeal nerve block: role.... 1874226 - Post-operative ... Anesthetics, Local / administration & dosage*. Brachial Plexus / drug effects*. Double-Blind Method. Drug Administration ...
Enhanced Tonic Inhibition Influences the Hypnotic and Amnestic Actions of the Intravenous Anesthetics Etomidate and Propofol |...
The excitability of neurons is determined by the combined efficacies of phasic and tonic inhibition. To explore how neurons ... 2003) General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor β3 subunit. FASEB J 17 ... 2009) Anesthetics discriminate between tonic and phasic γ-aminobutyric acid receptors on hippocampal CA1 neurons. Anesth Analg ... In DGGCs, anesthetic concentrations of etomidate (3 μm) significantly enhanced IPSC amplitude in WT mice [control I = 28.9 ± ...
New long-acting local anesthetic derived from algae effectively blocks pain in surgical patients - Healthcanal.com :...
They have data from animals and exploratory studies in humans showing that combining Site-1 sodium channel blockers with ... Current local anesthetics act for less than 8 hours; when they wear off, patients generally need opioid analgesics, which cause ... "In my opinion, there has not been a truly innovative new local anesthetic medication in the last 40 to 50 years," notes study ... It is a site 1 sodium-channel blocker, part of a larger class of emerging anesthetics based on molecules derived from aquatic ...
Topical drug formulations for prolonged corneal anesthesia.
Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ability ... Anesthetics, Combined. Anesthetics, Local / pharmacology*. Animals. Cell Line. Chemistry, Pharmaceutical. Cornea / drug effects ... 0/Anesthetics, Combined; 0/Anesthetics, Local; 0/Quaternary Ammonium Compounds; 0/Sodium Channel Blockers; 15461-38-8/ ... PURPOSE: Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ...
Opioids | Psychology Today
Studies show that treatment for opioid addiction using methadone at an adequate dosage level combined with behavioral therapy ... These include corticosteroids, anticonvulsants, antidepressants, local anesthetics, and stimulants. Opioids are only safe to ... These drugs slow down breathing, and the combined effects can result in life-threatening respiratory depression. ...
AnesthesiaLidocaineBupivacaineOpioidMetered-dose anestheticAnalgesicWidely used anestheticSelection of anestheticRegional anestheticSurgicalMedicationInduceManagement and perioperativeInjectionToxicityDexmedetomidineUnconsciousnessAnalgesiaPropofolConsiderationsSedativeLoss of sensationSystemicCreamsClinicalCesarean sectionInhalationalGeneralMidazolamAdequateCatheterBlockadeNerve blockPatientIntravenous anestheticsSensationCommonlyPotencyOutpatientDrugsTechniqueSurgeriesEtomidatePainfulSurgeryPainRelieveInvolvesSpinal cordIntrathecalTopical anestheticsPerineumLipidInjectionsDrugPeripheralInhalation anestheticsDifferences
Anesthesia40
- Perioperative anesthesia management and perioperative concerns of two major combined procedures are discussed. (medworm.com)
- To determine the feasibility and safety of outpatient combined intracavitary and interstitial brachytherapy for cervix cancer with sedation and local anesthesia. (termedia.pl)
- Outpatient combined intracavitary and interstitial brachytherapy for cervix cancer with sedation and local anesthesia is feasible and safe. (termedia.pl)
- Sometimes, conduction anesthesia is combined with general anesthesia or sedation for the patient's comfort and ease of surgery. (wikipedia.org)
- If the sensory block level was higher or unilateral, then a lower dose of intrathecal local anesthetic was selected and alternative options such as combined-spinal epidural and general anesthesia were increasingly favored. (hindawi.com)
- If a cesarean delivery is needed in a parturient with an existing labor epidural, it is common practice to convert or "top up" the epidural catheter [ 2 ], with the aim of initiating surgical anesthesia by injecting more concentrated local anesthetic, usually combined with a lipid soluble opioid. (hindawi.com)
- Our anesthesia group routinely performs 10-hour outpatient pediatric anesthetics for combined atresia-microtia ear reconstruction surgeries. (theanesthesiaconsultant.com)
- A 5-year-old male was with congenital atresia and microtia of the left ear was scheduled for combined atresia repair and microtia reconstruction under general anesthesia. (theanesthesiaconsultant.com)
- General anesthetics induce anesthesia throughout the body and can be administered either by inhalation or by direct injection into the bloodstream. (britannica.com)
- The ideal anesthetic agent allows rapid and pleasant induction (the process that brings about anesthesia), close control of the level of anesthesia and rapid reversibility, good muscle relaxation, and few toxic or adverse effects. (britannica.com)
- These systemic anesthetics result in a rapid onset of anesthesia after a single dose, because of their high solubility in lipids and their relatively high perfusion rate in the brain. (britannica.com)
- The intravenous anesthetics are frequently used for induction of anesthesia and are followed by an inhalational agent for maintenance of the anesthetic state. (britannica.com)
- Local anesthetics provide restricted anesthesia because they are administered to the peripheral sensory nerves innervating a region, usually by injection . (britannica.com)
- With the use of opioids, i.v. anesthetic agents, and their combinations, this rank order of effects can change and may even be deliberately altered in accordance with the variable goals of anesthesia. (aspetjournals.org)
- PURPOSE: Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ability to delay corneal healing makes them unsuitable for long-term use. (biomedsearch.com)
- This randomized, double-blind study was designed to compare single injection pectoral nerve block (Pecs I and Pecs II) versus local anesthetic infiltration for ambulatory breast augmentation under monitored anesthesia care (MAC). (springeropen.com)
- Exclusion criteria were ASA class ≥ III, contraindications to regional anesthesia (including coagulopathy and infection at the injection site), history of chronic use of opioids, body mass index (BMI) ≥ 35, uncooperative patients, and patients with known allergy to local anesthetics, opioids, NSAIDs, or paracetamol. (springeropen.com)
- General anesthetics elicit a state of general anesthesia . (wikipedia.org)
- While general anesthesia induction may be facilitated by one general anesthetic, others may be used in parallel or subsequently to achieve and maintain the desired anesthetic state. (wikipedia.org)
- Administration of topical anesthetics to control pain associated with procedures such as laceration repair may avoid the need for infiltrative local anesthesia injections and associated pain from the injections. (healthtap.com)
- Although it is evident that intravenous anesthetics are able to enhance GABA A R subtypes that mediate phasic and tonic inhibition, the relative contribution of these distinct forms of inhibition to the mechanism of anesthesia remains elusive. (jneurosci.org)
- The aim of the present study was to investigate the application of propofol combined with sevoflurane anesthesia in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). (spandidos-publications.com)
- However, as ALPPS is complex and the operation time is longer than that of common hepatectomy, the anesthesia requirements for ALPPS are high, which limits the use of numerous anesthetic methods and anesthetics. (spandidos-publications.com)
- Midazolam (MDZ) is an anesthetic inducer used for general anesthesia. (mdpi.com)
- A regional anesthetic may be combined with another type of anesthesia. (massgeneral.org)
- Combined spinal epidural anesthesia (CSEA) has advantages over single injection epidural or subarachnoid blockades. (scielo.br)
- This leads to prolonged nerve exposure to local anesthetics and reduced plasma levels, in addition to the potency of intrinsic vasoconstriction being partially associated with duration of anesthesia produced by the local anesthetic [ 3 , 14 ]. (hindawi.com)
- The effect of local anesthesia depends not only on the properties and concentration of the drug, but also on the thickness of the myelin sheath of the nerve fiber that prevents the penetration of the anesthetic through the cell membrane. (moluch.ru)
- to Study the features-actions* of modern domestic articaine-containing anesthetic «Supercain» to improve the efficiency and safety of local anesthesia by introducing into dental practice. (moluch.ru)
- Ubistesin combined preparation for local anesthesia in dentistry. (moluch.ru)
- general anesthesia (GA) group (group I) and combined general/epidural anesthesia group (CGEA) (group II). (who.int)
- 2019-02-24 characteristics, anesthesia time, surgical time, heart rate, mean arterial pressure (MAP), anesthetic / analgesic requirements, the occurrence of intraoperative bradycardia and/or hypotension, time to extubation, time to post anesthesia care unit (PACU) discharge and duration of PACU stay were recorded and considered for analysis. (who.int)
- L mostly performed under general combined general/epidural anesthesia on early anesthesia (GA) which is associated with recovery after spine surgery. (who.int)
- Modern labor analgesia favors initiation and maintenance of analgesia with low-dose local anesthesia and opioid solutions to minimize risks of local anesthetic systemic toxicity (unintentional intravascular injection) or high- or total-spinal anesthesia (unintentional intrathecal injection). (medscape.com)
- measured by serum cardiac troponin-T (Tn-T) in patients undergoing elective major abdominal cancer surgery with general anaesthesia or combined general and lumbar epidural anesthesia. (omicsonline.org)
- 30 patients each to receive general anesthesia (G1) or combined general and epidural anesthesia (G2). (omicsonline.org)
- Hemodynamic effects of epinephrine associated to an epidural clonidine-bupivacaine mixture during combined lumbar epidural and general anesthesia. (ac.be)
- Combined epidural and general anesthesia induced a significant decrease in arterial pressure and heart rate in both groups. (ac.be)
- Low dose epidural epinephrine decreases arterial pressure instability during combined epidural and general anesthesia. (ac.be)
- In few cases anaesthetist combines both general and local anesthesia techniques. (altiusdirectory.com)
Lidocaine7
- As background information, the free esters or amides of local anesthetics such as Lidocaine, Mepivacaine and Bupivacaine are basic substances due to the presence of the amino group. (google.com)
- J-Tip application of 1% buffered lidocaine before IV cannulation is not painful and has better anesthetic effectiveness compared with EMLA. (nih.gov)
- Lidocaine is an anesthetic agent that acts by blocking the nerve signals between sensory nerves where it is applied or injected. (wikihow.com)
- Cumulative concentration-response curves to local anesthetics (levobupivacaine, ropivacaine, lidocaine, and mepivacaine) were obtained from isolated rat aorta. (hindawi.com)
- Levobupivacaine and ropivacaine are long-acting aminoamide local anesthetics, whereas mepivacaine and lidocaine have an intermediate duration [ 13 ]. (hindawi.com)
- The main component of all these drugs is a local anesthetic - articaine, which determines, on the one hand, the General features of the action of all these drugs, and on the other-their distinctive features in comparison with drugs created on the basis of lidocaine or mepivacaine. (moluch.ru)
- Anesthetics such as lidocaine or bupivacaine may be combined with narcotics such as fentanyl or morphine. (dummies.com)
Bupivacaine4
- In addition, we have combined the new EST with local anesthetic injections (bupivacaine 0.25%) with clinical success. (experts.com)
- Combined spinal epidural (CSE) anaesthesia with bupivacaine and sufentanil was used for cesarean section under optimal monitoring . (bvsalud.org)
- In a randomized, double-blind trial, patients given neosaxitoxin, a new local anesthetic derived from algae, had significantly less postoperative pain and recovered about two days sooner than those given the commonly used local anesthetic bupivacaine. (healthcanal.com)
- Combined spinal epidural block was performed in the T 5 -T 6 space and 8 mg of 0.5% isobaric bupivacaine with 50 µg of morphine were injected in the subarachnoid space. (scielo.br)
Opioid7
- The medication includes an anesthetic that may be mixed with an opioid analgesic. (acog.org)
- To the best of our knowledge there is no report in literature of the use of sufentanil as a neuraxial opioid in the anesthetic management of cesarean section in a patient with PPCM. (bvsalud.org)
- Their work in rats showed that the compounds lack the side effects of existing anesthetics and opioid analgesics. (healthcanal.com)
- Antipsychotics (a.k.a. neuroleptics or tranquilizers) were investigated by the anesthesiologists De Castro and Mundeleer who coined the term neuroleptanalgesia, an anesthetic process that involves combining a major neuroleptic tranquilizer/antipsychotic with a potent opioid analgesic to produce a detached, pain-free state. (wikipedia.org)
- Small-dose intraspinal local anesthetics, when added to either epidural or intrathecal opioids, synergistically enhance the antinociceptive effects of the opioid dose, as demonstrated by isobolographic analysis (2) , likely because of inhibition of neuronal excitability. (lww.com)
- Moreover, temporary use of a local anesthetic alone can allow a "drug holiday" when opioid tolerance becomes a limiting factor for treatment. (lww.com)
- In combined spinal-epidural analgesia, the epidural space is located in the same fashion, and prior to threading the epidural catheter, a small 25- to 27-gauge spinal needle is introduced through the epidural needle to puncture the dura and to bolus a single dose of local anesthetic with or without opioid. (medscape.com)
Metered-dose anesthetic1
- The study drug is a metered-dose anesthetic spray, which is being developed for the treatment of premature ejaculation (PE). (clinicaltrials.gov)
Analgesic2
- LA drugs are also often combined with other agents such as opioids for synergistic analgesic action. (wikipedia.org)
- CGEA was significantly associated with reduction of intraoperative anesthetics / analgesic requirements, shorter time to extubation, time for PACU discharge and duration of PACU stay but on the expense of higher incidence of intraoperative hypotension. (who.int)
Widely used anesthetic1
- It is the most widely used anesthetic in veterinary medicine and is used for some surgical procedures in humans. (medicalnewstoday.com)
Selection of anesthetic2
- It obtained information on factors influencing the decision to utilize an existing labor epidural for cesarean section and, if epidural top up resulted in no objective sensory block, bilateral T10 sensory block, or unilateral T6 sensory block, factors influencing the management and selection of anesthetic technique. (hindawi.com)
- the existence of neurologic disorders (e.g., epilepsy or myasthenia gravis) influences the selection of anesthetic. (slideshare.net)
Regional anesthetic1
- It's a regional anesthetic that can be given at any stage of labor to numb the abdomen and therefore block the pain of contractions, but it's typically given when the woman is at least 4 cm dilated . (familyeducation.com)
Surgical8
- As of 2018, we are the only surgical/anesthetic practice in the world performing this surgery in high volume, and we are proud to have restored hearing and a cosmetic ear to hundreds of children from North America, Asia, Europe, and South America. (theanesthesiaconsultant.com)
- The surgical team of Joseph Roberson, M.D. and John Reinisch, M.D. regularly performs Combined Atresia-Microtia (CAM) ear reconstruction surgery on children born without normal ear anatomy. (theanesthesiaconsultant.com)
- The surgical procedure was combined atresia repair of the middle ear, reconstruction of the external auditory canal, and Medpor microtia reconstruction of an external ear. (theanesthesiaconsultant.com)
- Advances in surgical techniques and anesthetic management have rendered simultaneous multiple organ transplantation a viable option for carefully selected patients. (ekja.org)
- Thus, local anesthetics are useful in minor surgical procedures, such as the extraction of teeth . (britannica.com)
- As an adjuvant, it reduces anesthetic requirements and attenuates the hemodynamic responses to tracheal intubation and surgical stimuli, providing cardiovascular stability during surgery. (aspetjournals.org)
- Anesthetic drugs are used on patients prior to surgery to numb part of the body or to make a the patient unconscious during the surgical procedure. (sharecare.com)
- Boston, MA - A U.S.-Chile collaboration is bringing surgical patients closer to having a long-acting local anesthetic. (healthcanal.com)
Medication8
- A local anesthetic (LA) is a medication that causes absence of pain sensation. (wikipedia.org)
- Benzocaine is a local anesthetic (numbing medication). (sharecare.com)
- In my opinion, there has not been a truly innovative new local anesthetic medication in the last 40 to 50 years," notes study coauthor Charles Berde, MD, PhD, chief of the Division of Pain Medicine at Children's Hospital Boston. (healthcanal.com)
- The timing of IV insertion in our ED would allow for full medication effect of the currently marketed topical anesthetics in the majority of ED patients. (aappublications.org)
- 1-4 However, it has not been common practice to use these medications in the emergency department (ED). The requirements for successful and efficient application of topical anesthetic in the ED are 1) prospective identification of patients receiving IV insertions and 2) sufficient time between triage and IV insertion for the medication to take effect. (aappublications.org)
- Combining anesthetic ESI with anti-inflammatory medication seems to relieve neck pain better than either medication alone. (socom.mil)
- Glen's team wanted to find a medication that possesses the anesthetic power of thiopentone, but allows rapid recovery. (laskerfoundation.org)
- [ 14 , 15 ] A likely mechanism is the dural hole acts as a conduit to enhance epidural medication translocation into the intrathecal space, allowing enhanced coverage of sacral nerve roots while avoiding the side effects associated with conventional combined spinal-epidural analgesia. (medscape.com)
Induce6
- General anaesthetics (or anesthetics , see spelling differences ) are often defined as compounds that induce a loss of consciousness in humans or loss of righting reflex in animals. (wikipedia.org)
- [3] [5] It is possible to deliver anaesthesia solely by inhalation or injection, but most commonly the two forms are combined, with an injection given to induce anaesthesia and a gas used to maintain it. (wikipedia.org)
- General anesthetics that agonize them are typically used to induce a state of sedation and/or unconsciousness. (wikipedia.org)
- We propose that our isoflurane-2P imaging paradigm can serve as an attractive model system to dissect cellular and molecular mechanisms that induce the anesthetic state, and it might also provide important insight into sleep-like brain states and consciousness. (frontiersin.org)
- Aminoamide local anesthetics induce vasoconstriction in vivo and in vitro . (hindawi.com)
- Aminoamide local anesthetics induce vasoconstriction at low doses and vasodilation at high doses [ 1 ]. (hindawi.com)
Management and perioperative1
- Because of the rarity of pheochromocytoma, most data on the anesthetic management and perioperative outcomes have been reported in small case series that spanned many years. (uptodate.com)
Injection8
- An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the onset thereof, and for increasing its duration, and a means for preparing and dispensing the same, the composition containing a local parenteral anesthetic which in normal doses. (google.com)
- The invention also concerns a unique pH buffered, neutral or slightly basic aqueous composition containing a normally acidic parenteral anesthetic, but wherein a pH adjustment from acid to neutral or basic is made completely within a composite article in a hermetically sealed manner substantially immediately prior to injection of the composition. (google.com)
- The acid pH ranging, for example, between 3.5 to 6.5, of intradermal or subcutaneous anesthetic solutions and of most intravenous anesthetic solutions has been implicated as a factor responsible for local irritation at the site of injection, which leads to pain or discomfort during the period of infiltration. (google.com)
- An injection of an anesthetic drug into the space between the wall of the spinal canal and the covering of the spinal cord. (fpnotebook.com)
- J-Tip is a needle-less Food and Drug Administration approved injection system that can be used for delivery of local anesthetic before IV cannulation. (nih.gov)
- Combining a medium-viscosity dispersive and a viscous-cohesive viscoelastic in one syringe separated by an innovative bypass stopper system for a planned sequential injection. (zeiss.com)
- To gain access to the brain, anesthetics must be lipid soluble, but to achieve compatibility with blood, they must be presented in an aqueous solution for injection. (laskerfoundation.org)
- Depending on the vascularity of the injection site, vasoconstriction induced by local anesthetic and the addition of epinephrine may contribute to decreased absorption of local anesthetics into systemic circulation [ 14 ]. (hindawi.com)
Toxicity2
- Vadi, M.G., Patel, N. and Stiegler, M.P. (2014) Local Anesthetic Systemic Toxicity after Combined Psoas Compartment-Sciatic Nerve Block Analysis of Decision Factors and Diagnostic Delay. (scirp.org)
- They are not addictive, have no cardiac toxicity and don't cross the blood-brain barrier, thus avoiding the risk of seizures occasionally seen with existing local anesthetics. (healthcanal.com)
Dexmedetomidine4
- This study characterizes the anesthetic profile of dexmedetomidine on the basis of steady-state plasma concentrations using defined stimulus-response, ventilatory, and continuous electroencephalographic (EEG) and cardiovascular effect measures in rats. (aspetjournals.org)
- Recently, α 2 -adrenergic agonists, like dexmedetomidine, are being studied for potential use in anesthetic practice. (aspetjournals.org)
- To date, the anesthetic profile of dexmedetomidine has not been quantified on the basis of drug concentrations. (aspetjournals.org)
- The aim of this study was to compare the effect of ultrasound-guided pectoral nerve block and local anesthetic infiltration during ambulatory breast augmentation under MAC with dexmedetomidine on postoperative morphine consumption (our primary outcome), pain scores, postoperative nausea and vomiting (PONV), and patients' satisfaction. (springeropen.com)
Unconsciousness3
- [2] General anesthetics, however, typically elicit several key reversible effects: immobility, analgesia , amnesia , unconsciousness, and reduced autonomic responsiveness to noxious stimuli. (wikipedia.org)
- General anesthetics cause unconsciousness and total loss of sensation. (healthtap.com)
- The type of drug he sought-an induction agent-is used to sedate people so they can then tolerate inhaled anesthetics that maintain unconsciousness for long procedures. (laskerfoundation.org)
Analgesia13
- In this study, we compared the effectiveness of J-Tip versus eutectic mixture of local anesthetics (EMLA) to facilitate IV cannulation and provide adequate analgesia before IV placement. (nih.gov)
- The development of tolerance to morphine is delayed, and the quality of analgesia can be improved because of the morphine-sparing effect of local anesthetics (3) . (lww.com)
- Tachyphylaxis to local anesthetics is defined as a decrease in duration, segmental spread, or intensity of analgesia despite repeated constant dosages. (lww.com)
- Labor neuraxial analgesia is usually initiated by one of two methods: epidural or combined spinal-epidural analgesia (Figure 2). (medscape.com)
- [ 6 ] Combined spinal-epidural analgesia is often used for initiation of analgesia in advanced labor because of rapid onset of effective analgesia. (medscape.com)
- [ 7 , 8 ] Combined spinal-epidural analgesia has faster onset (2 to 5 min) than epidural analgesia (15 to 20 min), greater uniformity in sensory blockade, and improved sacral dermatome coverage. (medscape.com)
- [ 9 ] While some studies report greater satisfaction and sense of control associated with combined spinal-epidural analgesia, the meta-analyses do not support this observation. (medscape.com)
- however, a 2016 study suggests that may not be the case, and favors combined spinal-epidural analgesia for earlier detection of failed epidural analgesia. (medscape.com)
- [ 13 ] A higher risk of uterine tachysystole after combined spinal-epidural analgesia than epidural analgesia has been reported and may be attributable to the rapid decrease in circulating catecholamines (which have a tocolytic effect) that accompanies rapid-onset of labor analgesia. (medscape.com)
- Epidural analgesia technique ( A ) versus combined spinal-epidural technique ( B ). In epidural analgesia, the epidural space is located using an epidural needle, by a loss-of-resistance technique. (medscape.com)
- A modification of the combined spinal-epidural technique is dural puncture epidural analgesia. (medscape.com)
- Dural puncture epidural analgesia may be associated with improved sacral analgesia compared to epidural analgesia, with less pruritus, hypotension, supplemental epidural doses, and uterine tachysystole than combined spinal-epidural analgesia. (medscape.com)
- en] Clonidine or epinephrine are frequently combined to epidural local anesthetics to strengthen sensory block and prolong analgesia. (ac.be)
Propofol3
- Collectively, these observations suggest that potentiation of tonic inhibition mediated by α4 subunit containing GABA A Rs contributes to the hypnotic and amnestic actions of the intravenous anesthetics, etomidate and propofol. (jneurosci.org)
- In conclusion, propofol combined with sevoflurane has a good application value in ALPPS. (spandidos-publications.com)
- Propofol delivered its anesthetic effects smoothly and safely, and people recovered quickly, with minimal grogginess, nausea, or other lingering unpleasantness. (laskerfoundation.org)
Considerations4
- In this case report, we focus on the specific anesthetic considerations for CHLT pertaining to the challenges associated with dual pathophysiology. (ekja.org)
- Perioperative and anesthetic considerations in truncus arteriosus. (seattlechildrens.org)
- Anesthetic and Perioperative Considerations for Combined Heart-Kidney Transplantation. (amedeo.com)
- Donohue syndrome: A review of literature, case series, and anesthetic considerations. (amedeo.com)
Sedative1
- Tramadol may increase central nervous system and respiratory depression when combined with alcohol, anesthetics, narcotics, tranquilizers, or sedative hypnotics. (medicinenet.com)
Loss of sensation1
- Anesthetic , also spelled anaesthetic , any agent that produces a local or general loss of sensation, including pain . (britannica.com)
Systemic2
- They have data from animals and exploratory studies in humans showing that combining Site-1 sodium channel blockers with existing local anesthetics can produce nerve blockade for up to 2 to 4 days - with minimal local or systemic side effects. (healthcanal.com)
- Mohamed SA, Fares KM, Hasan-Ali H, Bakry R (2013) The Effect of Anesthetic Technique on Cardiac Troponin-T and Systemic Inflammatory Response after Major Abdominal Cancer Surgery. (omicsonline.org)
Creams3
- The use of anesthetic in topical creams has been well established. (clinicaltrials.gov)
- Could we use mild topical anesthetic creams for cancer patients? (healthtap.com)
- Can mild topical anesthetic creams be used for cancer patients? (healthtap.com)
Clinical7
- Clinical LAs belong to one of two classes: aminoamide and aminoester local anesthetics. (wikipedia.org)
- Based on this finding, Children's Hospital Boston, a co-investigator on the study, has signed a collaboration agreement with biotech start-up company Proteus SA (Santiago, Chile) to move the new anesthetic toward clinical adoption. (healthcanal.com)
- We have published hundreds of Forgiveness Combined With Acetaminophen Alleviate Social Pain news stories on BioPortfolio along with dozens of Forgiveness Combined With Acetaminophen Alleviate Social Pain Clinical Trials and PubMed Articles about Forgiveness Combined With Acetaminophen Alleviate Social Pain for you to read. (bioportfolio.com)
- In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Forgiveness Combined With Acetaminophen Alleviate Social Pain Companies in our database. (bioportfolio.com)
- committee, this prospective, randomized, Fast-track anesthetic management was controlled, single-blinded clinical study was demonstrated to be highly safe and efficient to conducted in Zagazig University Hospitals improve patient recovery and satisfaction from 12/2016 to 12/2017. (who.int)
- one week before operation and rechecked at Adequate anesthetic state was considered the night of surgery according to the standard when heart rate (HR) and arterial blood protocols including history taking, clinical pressure (ABP) remained stable for 10 examination, assessment of the minutes or more after the start of surgery. (who.int)
- General Anesthetics to Treat Major Depressive Disorder: Clinical Relevance and Underlying Mechanisms. (amedeo.com)
Cesarean section3
- In the setting of a failed epidural top up, the most influential factors determining further anesthetic management were the category of cesarean section (92%), dermatomal level of blockade (78%), and the assessment of maternal airway. (hindawi.com)
- Peripartum cardiomyopathy (PPCM) is a rare entity, and anesthetic management for cesarean section of a patient with this condition can be challenging. (bvsalud.org)
- We hereby present the anesthetic management of a patient with PPCM complicated with preeclampsia scheduled for cesarean section , along with a mini review of literature . (bvsalud.org)
Inhalational2
- Inhalational anesthetics are administered in combination with oxygen, and most are excreted by the lungs with little or no metabolism by the body. (britannica.com)
- Except for the naturally occurring gas nitrous oxide (laughing gas), all the major inhalational anesthetics are hydrocarbons , compounds formed of carbon and hydrogen atoms. (britannica.com)
General10
- A previous general anesthetic for adenoidectomy at the age of 2 was unremarkable. (theanesthesiaconsultant.com)
- In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general anesthetic. (wikipedia.org)
- In general, there are two types of drugs for pain relief: 1) analgesics and 2) anesthetics . (acog.org)
- The relationship between the amount of general anesthetic administered and the depression of the brain's sensory responsiveness is arbitrarily, but usefully, divided into four stages. (britannica.com)
- Not infrequently, general anesthetics are combined with drugs that block neuromuscular impulse transmission. (britannica.com)
- Individual general anesthetics vary with respect to their specific physiological and cognitive effects. (wikipedia.org)
- General anesthetics are commonly used in animal models to study how sensory signals are represented in the brain. (frontiersin.org)
- Here, we used two-photon (2P) calcium activity imaging with cellular resolution to investigate how neuronal activity in layer 2/3 of the mouse barrel cortex is modified under the influence of different concentrations of chemically distinct general anesthetics. (frontiersin.org)
- Each general anesthetic involves the use of many different medications. (hubpages.com)
- May be the patient requires additional analgesics, IV sedation, or a light general anesthetic. (altiusdirectory.com)
Midazolam1
- Hidaka Y, Chiba-Ohkuma R, Karakida T, Onuma K, Yamamoto R, Fujii-Abe K, Saito MM, Yamakoshi Y, Kawahara H. Combined Effect of Midazolam and Bone Morphogenetic Protein-2 for Differentiation Induction from C2C12 Myoblast Cells to Osteoblasts. (mdpi.com)
Adequate1
- Narcotics decrease the amount of local anesthetics needed to achieve adequate comfort. (dummies.com)
Catheter2
- To investigate the potential for pediatric emergency department (ED) triage nurses to apply a topical anesthetic (ie, eutectic mixture of local anesthetic) for intravenous catheter (IV) insertion. (aappublications.org)
- Topically applied local anesthetics have been shown to reduce the pain associated with intravenous catheter (IV) insertion significantly. (aappublications.org)
Blockade1
- Epidural anesthetic blockade is considered an in the study. (who.int)
Nerve block3
- Combined electrochemical nerve block reduced pain in 80% of patients with neuropathies and 50% of patients with intractable back pain. (experts.com)
- This technique provides a combined (electrical and chemical) nerve block that enhances treatment of a neuropathy or a painful condition (see Tables 1 and 2, page 63). (experts.com)
- When it is used on specific nerve pathways ( local anesthetic nerve block ), paralysis (loss of muscle power) also can be achieved. (wikipedia.org)
Patient2
- Patient underwent combined right atrial thrombectomy and living donor liver transplantation (LDLT) in the same setting. (medworm.com)
- A nurse needs to accompany the patient to see to their medical needs en route. (aol.com)
Intravenous anesthetics3
- Intravenous anesthetics exert a component of their actions via potentiating inhibitory neurotransmission mediated by γ-aminobutyric type-A receptors (GABA A Rs). (jneurosci.org)
- Intravenous anesthetics are known to act via γ-aminobutyric acid type A receptors (GABA A Rs), which are ligand-gated ion channels assembled from multiple subunit classes. (jneurosci.org)
- through mergers, ICI eventually became AstraZeneca) to help find new short-acting intravenous anesthetics. (laskerfoundation.org)
Sensation1
- When the local anesthetic is injected, you may feel a scratching sensation and experience a very short-lived sting in the area between the vertebrae bones. (familyeducation.com)
Commonly1
- Nitrous oxide (N 2 O) is a commonly used inhaled anesthetic in outpatient dental procedures. (nih.gov)
Potency5
- The goals of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contraction. (hindawi.com)
- The potency of the vasoconstriction in the endothelium-denuded aorta induced by local anesthetics is determined primarily by lipid solubility and, in part, by other physicochemical properties including potency and pKa. (hindawi.com)
- In addition, the membrane disordering efficiency of local anesthetics corresponds to their potency [ 4 ]. (hindawi.com)
- However, to our knowledge, the physicochemical property of local anesthetics that is primarily responsible for determining the local anesthetic-induced vasoconstriction potency has not yet been identified. (hindawi.com)
- Therefore, the aims of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to determine which physicochemical property is principally involved in determining this potency in isolated rat aortic rings. (hindawi.com)
Outpatient1
- Leong Y, Tan K, Ai Choo B, Koh V, Tang J. Novel anesthetic technique for combined intracavitary and interstitial brachytherapy for cervix cancer in an outpatient setting. (termedia.pl)
Drugs6
- These drugs slow down breathing, and the combined effects can result in life-threatening respiratory depression . (psychologytoday.com)
- You can also find out about relevant Forgiveness Combined With Acetaminophen Alleviate Social Pain Drugs and Medications on this site too. (bioportfolio.com)
- Study design and methodology were chosen to dissociate the state-related changes in consciousness from the effects of the anesthetic drugs. (jneurosci.org)
- It did not cause the muscle twitching and tremors that plagued many anesthetics, and it could be combined safely with a variety of other drugs typically used for sedation. (laskerfoundation.org)
- It may cause serotonin syndrome when combined with other drugs that also increase serotonin (see drug interactions section). (medicinenet.com)
- Ketamine belongs to a class of drugs known as dissociative anesthetics. (medicalnewstoday.com)
Technique2
- This case provides evidence that segmental spinal block can be the anesthetic technique used in gastrointestinal surgeries with spontaneous respiration. (scielo.br)
- [ 10 ] Other studies have shown that epidural catheters sited as part of a combined spinal-epidural technique fail less often, both during labor and for intrapartum cesarean delivery. (medscape.com)
Surgeries3
- The total anesthetic time for these surgeries regularly totals 9- 10 hours. (theanesthesiaconsultant.com)
- Surgeries are performed at California Ear Institute in East Palo Alto, CA, and Waverley Surgery Center in Palo Alto, CA. The text below describes a the anesthetic care for a typical CAM reconstruction. (theanesthesiaconsultant.com)
- This study proved that CGEA seems to be an effective fast track anesthetic protocol in patients undergoing elective lumbar spine surgeries. (who.int)
Etomidate1
- Y365/7F mice exhibited a gender-specific enhancement of tonic inhibition in the dentate gyrus that was more sensitive to modulation by the anesthetic etomidate, together with a deficit in long-term potentiation. (jneurosci.org)
Painful2
- Diagnostic tests such as bone marrow aspiration, lumbar puncture (spinal tap) and aspiration of cysts or other structures are made to be less painful upon administration of local anesthetic before insertion of larger needles. (wikipedia.org)
- For painful joints anesthetic and steroid can be injected. (jefferson.edu)
Surgery3
- The perfect match of two OVDs for the entire surgery, provided in two seperate syringes or combined in one syringe. (zeiss.com)
- However, many of these products can have serious and potentially harmful side effects when combined with medications prescribed during and after surgery, according to a review article in the Journal of the American Academy of Orthopaedic Surgeons (JAAOS). (bio-medicine.org)
- The anesthetic action extends for longer time than required and that provides pain relief for several hours after the surgery. (altiusdirectory.com)
Pain14
- This article describes a new electromagnetic device and its use in combination with local anesthetic therapy to treat pain problems. (experts.com)
- Anesthetics relieve pain by blocking most feeling, including pain. (acog.org)
- Local anesthetics provide relief from pain in these areas. (acog.org)
- Measurements of success of cannulation (number of attempts for IV placement) and pain (0-10 visual analog scale) at application of local anesthetic and at cannulation were performed. (nih.gov)
- Anesthetic is a drug or substance that blocks pain and causes loss of feeling. (sharecare.com)
- Elma is a topical local anesthetic that aids in reducing the pain of IV placement. (healthtap.com)
- All of these are topical anesthetics, meaning that they can be applied directly to skin or mucous membranes to treat minor pain such as teething or scrapes, or itching from poison ivy or insect bites. (healthtap.com)
- Here you can see the latest Forgiveness Combined With Acetaminophen Alleviate Social Pain articles that have been published worldwide. (bioportfolio.com)
- However, ESIs are frequently combined with various other types of treatments for chronic pain. (socom.mil)
- Moreover, other factors of pharmacodynamic origin have been implicated, such as antagonistic effects of nucleotides or increased sodium concentration, increased afferent input from nociceptors, or receptor downregulation of the sodium channels, and often the interpretation is quite difficult because of time-dependent variations in pain or circadian changes in the duration of local anesthetic action: phenomena that are named pseudotachyphylaxis (5) . (lww.com)
- The following are the choices of pain-relief medications are available: Analgesics and anesthetics. (mommybknowsbest.com)
- Anesthetics block nerve transmission to pain centers, resulting in blocking the feeling of pain. (mommybknowsbest.com)
- The anesthetic drug is given just before delivery to relieve pain during childbirth. (mommybknowsbest.com)
- Before dehorning a cow, it is recommended that local anesthetics be injected into the corneal nerve to remove any pain that might be felt by the cow during dehorning. (wikihow.com)
Relieve1
- How do topical anesthetics relieve itchy skin? (sharecare.com)
Involves2
- An anesthetic procedure that involves administering pharmaceutical agents into the epidural space of the spinal canal. (fpnotebook.com)
- Analysis of a medical term involves breaking down the term into its prefix, word root (or combining form), and suffix. (answers.com)
Spinal cord2
Intrathecal2
Topical anesthetics1
- Topical anesthetics are medications that help soothe itchy or irritated skin. (sharecare.com)
Perineum1
- The anesthetic drug is injected into the area around the nerves that carry feeling to the vagina , vulva , and perineum . (acog.org)
Lipid1
- The application of this material with a clinically useful anesthetic presented the possibility of testing a bank of previously synthesized lipid-soluble chemicals that ICI had stored in its compound collection. (laskerfoundation.org)
Injections2
- This invention concerns the modification of materials normally employed as parenteral anesthetics in acidic solution, and particularly concerns a composite article and its method of use which provides in a very convenient manner a buffering system for addition to these acidic materials for reducing certain adverse physiological effects thereof such as burning or stinging generally resulting from injections thereof. (google.com)
- local anesthetics combined with long-acting corticosteroid injections. (spineuniverse.com)
Drug3
- An anesthetic drug is given through an IV line or through a mask. (mommybknowsbest.com)
- In addition to serving as a new induction agent, such a drug might maintain sedation and thus provide an injected alternative to inhaled anesthetics. (laskerfoundation.org)
- It is a class III scheduled drug and is approved for use in hospitals and other medical settings as an anesthetic. (medicalnewstoday.com)
Peripheral2
- Anesthetics achieve this effect by acting on the brain or peripheral nervous system to suppress responses to sensory stimulation. (britannica.com)
- Expert opinion: There are arguments that the current topical therapeutics for NP rely too heavily on the use of local anesthetics and capsaicinoids, and more research is certainly needed on topical therapies that are multimodal and/or are targeted at the peripheral sources of pathology. (unboundmedicine.com)
Inhalation anesthetics1
- It may depress cardiovascular function in particular when combined with inhalation anesthetics. (lww.com)
Differences1
- We found MEPs could be induced under both anesthetics, with no differences in the resting motor threshold or the average baseline amplitudes. (frontiersin.org)