Anesthetics: Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Anesthetics, Inhalation: Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)Anesthetics, General: Agents that induce various degrees of analgesia; depression of consciousness, circulation, and respiration; relaxation of skeletal muscle; reduction of reflex activity; and amnesia. There are two types of general anesthetics, inhalation and intravenous. With either type, the arterial concentration of drug required to induce anesthesia varies with the condition of the patient, the desired depth of anesthesia, and the concomitant use of other drugs. (From AMA Drug Evaluations Annual, 1994, p.173)Anesthetics, Intravenous: Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.Halothane: A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)Anesthetics, Combined: The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.Enflurane: An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.Methyl Ethers: A group of compounds that contain the general formula R-OCH3.Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.Anesthetics, Dissociative: Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed)Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.Anesthesia, Local: A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.Methoxyflurane: An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)Anesthesia, General: Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.Bupivacaine: A widely used local anesthetic agent.Anesthesia, Inhalation: Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.Benzocaine: A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.Anesthesia, Dental: A range of methods used to reduce pain and anxiety during dental procedures.Tetracaine: A potent local anesthetic of the ester type used for surface and spinal anesthesia.Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.Nerve Block: Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.Thiopental: A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.Etomidate: Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.Anesthesiology: A specialty concerned with the study of anesthetics and anesthesia.Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)Dibucaine: A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)Anesthesia, Intravenous: Process of administering an anesthetic through injection directly into the bloodstream.Etidocaine: A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.Carticaine: A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.Anesthesia, Conduction: Injection of an anesthetic into the nerves to inhibit nerve transmission in a specific part of the body.Anesthesia, Epidural: Procedure in which an anesthetic is injected into the epidural space.Adjuvants, Anesthesia: Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.Anesthesia Recovery Period: The period of emergence from general anesthesia, where different elements of consciousness return at different rates.Anesthesia, Obstetrical: A variety of anesthetic methods such as EPIDURAL ANESTHESIA used to control the pain of childbirth.EthersHypnosis, Anesthetic: Procedure in which an individual is induced into a trance-like state to relieve pain. This procedure is frequently performed with local but not general ANESTHESIA.Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)Pregnanediones: Pregnane derivatives in which two side-chain methyl groups or two methylene groups in the ring skeleton (or a combination thereof) have been oxidized to keto groups.Xenon: A noble gas with the atomic symbol Xe, atomic number 54, and atomic weight 131.30. It is found in the earth's atmosphere and has been used as an anesthetic.Anesthesia, Spinal: Procedure in which an anesthetic is injected directly into the spinal cord.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Chlorofluorocarbons: A series of hydrocarbons containing both chlorine and fluorine. These have been used as refrigerants, blowing agents, cleaning fluids, solvents, and as fire extinguishing agents. They have been shown to cause stratospheric ozone depletion and have been banned for many uses.Medetomidine: An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.Monitoring, Intraoperative: The constant checking on the state or condition of a patient during the course of a surgical operation (e.g., checking of vital signs).Hypnotics and Sedatives: Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.Octanols: Isomeric forms and derivatives of octanol (C8H17OH).Anesthesia Department, Hospital: Hospital department responsible for the administration of functions and activities pertaining to the delivery of anesthetics.Pain, Postoperative: Pain during the period after surgery.Ambulatory Surgical Procedures: Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.Preanesthetic Medication: Drugs administered before an anesthetic to decrease a patient's anxiety and control the effects of that anesthetic.Amides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)Receptors, GABA-A: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.Mandibular Nerve: A branch of the trigeminal (5th cranial) nerve. The mandibular nerve carries motor fibers to the muscles of mastication and sensory fibers to the teeth and gingivae, the face in the region of the mandible, and parts of the dura.Volatilization: A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.Chloralose: A derivative of CHLORAL HYDRATE that was used as a sedative but has been replaced by safer and more effective drugs. Its most common use is as a general anesthetic in animal experiments.Ethyl EthersMidazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.Acepromazine: A phenothiazine that is used in the treatment of PSYCHOSES.Barbiturates: A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Urethane: Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.Tiletamine: Proposed anesthetic with possible anticonvulsant and sedative properties.Zolazepam: A pyrazolodiazepinone with pharmacological actions similar to ANTI-ANXIETY AGENTS. It is commonly used in combination with TILETAMINE to obtain immobilization and anesthesia in animals.1-Octanol: A colorless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticizers. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Consciousness Monitors: Devices used to assess the level of consciousness especially during anesthesia. They measure brain activity level based on the EEG.Injections: Introduction of substances into the body using a needle and syringe.Alfaxalone Alfadolone Mixture: A 3:1 mixture of alfaxalone with alfadolone acetate that previously had been used as a general anesthetic. It is no longer actively marketed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1445)Conscious Sedation: A drug-induced depression of consciousness during which patients respond purposefully to verbal commands, either alone or accompanied by light tactile stimulation. No interventions are required to maintain a patent airway. (From: American Society of Anesthesiologists Practice Guidelines)Intubation, Intratracheal: A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.Malignant Hyperthermia: Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Brachial Plexus: The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.Operating Rooms: Facilities equipped for performing surgery.Dental Pulp Test: Investigations conducted on the physical health of teeth involving use of a tool that transmits hot or cold electric currents on a tooth's surface that can determine problems with that tooth based on reactions to the currents.Analgesia: Methods of PAIN relief that may be used with or in place of ANALGESICS.Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Analgesia, Epidural: The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Intraoperative Complications: Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.Sufentanil: An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.Anesthesia, IntratrachealSodium Channels: Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.CyclobutanesHemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Sciatic Nerve: A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.Consciousness: Sense of awareness of self and of the environment.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Depression, Chemical: The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.Dexmedetomidine: A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound.Felypressin: A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.Perioperative Care: Interventions to provide care prior to, during, and immediately after surgery.Intraoperative Period: The period during a surgical operation.Chloral Hydrate: A hypnotic and sedative used in the treatment of INSOMNIA.Analgesia, Obstetrical: The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Ligand-Gated Ion Channels: A subclass of ion channels that open or close in response to the binding of specific LIGANDS.Hexanols: Isomeric forms and derivatives of hexanol (C6H11OH).Hydrocarbons, HalogenatedTooth Extraction: The surgical removal of a tooth. (Dorland, 28th ed)Xenopus laevis: The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.Potassium Channels, Tandem Pore Domain: Potassium channels that contain two pores in tandem. They are responsible for baseline or leak currents and may be the most numerous of all K channels.Propanidid: An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918)Alcohols: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)Injections, Epidural: The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.Cesarean Section: Extraction of the FETUS by means of abdominal HYSTEROTOMY.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Flurothyl: A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.Maxillary Nerve: The intermediate sensory division of the trigeminal (5th cranial) nerve. The maxillary nerve carries general afferents from the intermediate region of the face including the lower eyelid, nose and upper lip, the maxillary teeth, and parts of the dura.Apoferritins: The protein components of ferritins. Apoferritins are shell-like structures containing nanocavities and ferroxidase activities. Apoferritin shells are composed of 24 subunits, heteropolymers in vertebrates and homopolymers in bacteria. In vertebrates, there are two types of subunits, light chain and heavy chain. The heavy chain contains the ferroxidase activity.Anesthesia, Closed-Circuit: Inhalation anesthesia where the gases exhaled by the patient are rebreathed as some carbon dioxide is simultaneously removed and anesthetic gas and oxygen are added so that no anesthetic escapes into the room. Closed-circuit anesthesia is used especially with explosive anesthetics to prevent fires where electrical sparking from instruments is possible.Needles: Sharp instruments used for puncturing or suturing.Sodium Channel Blockers: A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.Gas Scavengers: Apparatus for removing exhaled or leaked anesthetic gases or other volatile agents, thus reducing the exposure of operating room personnel to such agents, as well as preventing the buildup of potentially explosive mixtures in operating rooms or laboratories.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Receptors, Glycine: Cell surface receptors that bind GLYCINE with high affinity and trigger intracellular changes which influence the behavior of cells. Glycine receptors in the CENTRAL NERVOUS SYSTEM have an intrinsic chloride channel and are usually inhibitory.Ion Channel Gating: The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.Alfentanil: A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.Surgical Procedures, Operative: Operations carried out for the correction of deformities and defects, repair of injuries, and diagnosis and cure of certain diseases. (Taber, 18th ed.)Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)Aminobenzoates: Derivatives of BENZOIC ACID that contain one or more amino groups attached to the benzene ring structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobenzoate structure.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Patch-Clamp Techniques: An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.Unconsciousness: Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Postoperative Nausea and Vomiting: Emesis and queasiness occurring after anesthesia.Euthanasia, Animal: The killing of animals for reasons of mercy, to control disease transmission or maintain the health of animal populations, or for experimental purposes (ANIMAL EXPERIMENTATION).Reflex: An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Thiamylal: A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)Analgesics: Compounds capable of relieving pain without the loss of CONSCIOUSNESS.Hydrocarbons, FluorinatedDrug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.Molar, Third: The aftermost permanent tooth on each side in the maxilla and mandible.Injections, Spinal: Introduction of therapeutic agents into the spinal region using a needle and syringe.Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.Ethyl Chloride: A gas that condenses under slight pressure. Because of its low boiling point ethyl chloride sprayed on skin produces an intense cold by evaporation. Cold blocks nerve conduction. Ethyl chloride has been used in surgery but is primarily used to relieve local pain in sports medicine.Laryngismus: A disorder in which the adductor muscles of the VOCAL CORDS exhibit increased activity leading to laryngeal spasm. Laryngismus causes closure of the VOCAL FOLDS and airflow obstruction during inspiration.Nordefrin: A norepinephrine derivative used as a vasoconstrictor agent.Femoral Nerve: A nerve originating in the lumbar spinal cord (usually L2 to L4) and traveling through the lumbar plexus to provide motor innervation to extensors of the thigh and sensory innervation to parts of the thigh, lower leg, and foot, and to the hip and knee joints.Butorphanol: A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.Batrachotoxins: Batrachotoxin is the 20-alpha-bromobenzoate of batrachotoxin A; they are toxins from the venom of a small Colombian frog, Phyllobates aurotaenia, cause release of acetylcholine, destruction of synaptic vesicles and depolarization of nerve and muscle fibers.Surgical Procedures, Minor: Surgery restricted to the management of minor problems and injuries; surgical procedures of relatively slight extent and not in itself hazardous to life. (Dorland, 28th ed & Stedman, 25th ed)Chlorofluorocarbons, Methane: A group of methane-based halogenated hydrocarbons containing one or more fluorine and chlorine atoms.Receptors, Nicotinic: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.Operating Room Technicians: Specially trained personnel to assist in routine technical procedures in the operating room.1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Postanesthesia Nursing: The specialty or practice of nursing in the care of patients in the recovery room following surgery and/or anesthesia.Carbon Dioxide: A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.Benzyl Alcohol: A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.GABA Modulators: Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.Oocytes: Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Injections, Intra-Articular: Methods of delivering drugs into a joint space.Pulmonary Alveoli: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.Vasoconstrictor Agents: Drugs used to cause constriction of the blood vessels.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Ischemic Preconditioning, Myocardial: Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.Receptors, GABA: Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.Intraoperative Awareness: Occurence of a patient becoming conscious during a procedure performed under GENERAL ANESTHESIA and subsequently having recall of these events. (From Anesthesiology 2006, 104(4): 847-64.)Blood Gas Analysis: Measurement of oxygen and carbon dioxide in the blood.Trichloroethanes: Chlorinated ethanes which are used extensively as industrial solvents. They have been utilized in numerous home-use products including spot remover preparations and inhalant decongestant sprays. These compounds cause central nervous system and cardiovascular depression and are hepatotoxic. Include 1,1,1- and 1,1,2-isomers.Heart: The hollow, muscular organ that maintains the circulation of the blood.Subarachnoid Space: The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.CyclopropanesAdministration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Synaptosomes: Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates.Neuromuscular Nondepolarizing Agents: Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.Autonomic Nerve Block: Interruption of sympathetic pathways, by local injection of an anesthetic agent, at any of four levels: peripheral nerve block, sympathetic ganglion block, extradural block, and subarachnoid block.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Pancuronium: A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.Infusion Pumps: Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.Analgesia, Patient-Controlled: Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Syringes: Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Adrenergic alpha-Agonists: Drugs that selectively bind to and activate alpha adrenergic receptors.Equipment and Supplies, Hospital: Any materials used in providing care specifically in the hospital.

Effect of remifentanil on the auditory evoked response and haemodynamic changes after intubation and surgical incision. (1/302)

We have observed the effect of intubation and incision, as measured by the auditory evoked response (AER) and haemodynamic variables, in 12 patients undergoing hernia repair or varicose vein surgery who received remifentanil as part of either an inhaled anaesthetic technique using isoflurane or as part of a total i.v. technique using propofol. Anaesthesia was induced with remifentanil 1 microgram kg-1 and propofol, neuromuscular block was achieved with atracurium 0.6 mg kg-1 before intubation, and anaesthesia was maintained with a continuous infusion of remifentanil in combination with either a continuous infusion of propofol or inhaled isoflurane. The AER and haemodynamic variables were measured before and after intubation and incision. The effects of intubation and incision on the AER and haemodynamic variables were not significantly different between the remifentanil-propofol and remifentanil-isoflurane groups. However, the study had a low power for this comparison. When the data for the two anaesthetic combinations were pooled, the only significant effects were increases in diastolic arterial pressure and heart rate immediately after intubation; these were not seen 5 min after intubation. There were no cardiovascular responses to incision. There were no significant changes in the AER after intubation or incision.  (+info)

Concentration and second-gas effects in the water analogue. (2/302)

The water analogue provides a visual model of the process of anaesthetic exchange. In the standard version, a single pipe connects the mouth container to the lung container and the conductance of this mouth-lung pipe is proportional to alveolar ventilation. This implies that inspired and expired ventilations are equal. In fact, with high inspired concentrations of nitrous oxide, early rapid uptake of gas by solution leads to a substantial difference between inspired and expired ventilation which in turn leads to concentration and second-gas effects. It is shown that by representing inspired and expired ventilations separately, and keeping one of them constant while varying the other to compensate for rapid uptake, concentration and second-gas effects are reproduced in the water analogue. Other means of reproducing the effects are reported but we believe that the first method is the most realistic and the most appropriate for teaching.  (+info)

Recovery after halothane anaesthesia induced with thiopental, propofol-alfentanil or halothane for day-case adenoidectomy in small children. (3/302)

We studied recovery from halothane anaesthesia in 93 children, aged 1-3 yr, undergoing day-case adenoidectomy. Children were allocated randomly to receive thiopental 5 mg kg-1 (group TH), alfentanil 10 micrograms kg-1 and propofol 3 mg kg-1 (group PAH) or 5% halothane (group HH) for induction of anaesthesia. In group TH, tracheal intubation was facilitated with succinylcholine (suxamethonium) 1.5 mg kg-1. In groups PAH and HH, tracheal intubation was performed without neuromuscular block, and succinylcholine was used only if required. Anaesthesia was maintained with 1-3% halothane during spontaneous respiration. Times to achieving predetermined recovery end-points were recorded. Quality of recovery was assessed using a score of 1-9 (best to worst) for sedation, crying, restlessness and agitation. A postoperative questionnaire was used to determine the well-being of the child at home, 24 h after operation. Emergence from anaesthesia (response to non-painful stimuli) occurred earlier in group HH (mean 9 (SD 6) min) than in groups PAH (13 (6) min, P < 0.01) and TH (18 (14) min, P < 0.01). Sitting up, walking and home readiness were achieved earlier in groups PAH and HH than in group TH (P < 0.05 for each variable). Children in group TH were more sedated during the first 30 min after anaesthesia than those in the two other groups (P < 0.05) while emergence-related delirium was more common in group HH than in group TH (P < 0.01). Well-being at home was similar in all groups. We conclude that induction of halothane anaesthesia with propofol-alfentanil or halothane provided more rapid recovery and earlier discharge than that with thiopental.  (+info)

Haemodynamic stability and ketamine-alfentanil anaesthetic induction. (4/302)

We have determined if alfentanil could obtund the haemodynamic instability commonly seen at induction of anaesthesia with ketamine. Five groups of ASA I and II patients received ketamine 1 mg kg-1 i.v., preceded by saline (group 1) or alfentanil 10, 20, 30 or 40 micrograms kg-1 (groups 2-5, respectively). Heart rate (HR), mean arterial pressure (AP), postoperative patient complaints and dysphoria were noted. All groups showed increases (P < 0.05) in both HR and AP after administration of ketamine, which were progressively smaller as the dose of alfentanil increased. After tracheal intubation, all groups showed further increases in HR and AP, with groups 3-5 (alfentanil 20-40 micrograms kg-1) showing significant obtundation (P < 0.05) of these increases compared with group 1. No patient in any group reported postoperative dysphoria or dissatisfaction with their anaesthetic. Ketamine 1 mg kg-1 with alfentanil 20-40 micrograms kg-1 provided statistically significant obtundation of the haemodynamic instability that is common with ketamine alone.  (+info)

Comparison of recovery of propofol and methohexital sedation using an infusion pump. (5/302)

Two sedative anesthetic agents administered by an infusion pump were compared during third molar surgery. Forty American Society of Anesthesiologists (ASA) class I or II volunteers were randomly allocated to two groups. All subjects received supplemental oxygen via a nasal hood, fentanyl (0.0007 mg/kg intravenous [i.v.] bolus), and midazolam (1 mg/2 min) titrated to effect. Patients then received either 0.3 mg/kg of methohexital or 0.5 mg/kg of propofol via an infusion pump. Upon completion of the bolus, a continuous infusion of 0.05 mg/kg/min methohexital or 0.066 mg/kg/min propofol was administered throughout the procedure. Hemo-dynamic and respiratory parameters and psychomotor performance were compared for the two groups and no significant differences were found. The continuous infusion method maintained a steady level of sedation. Patients receiving propofol had a smoother sedation as judged by the surgeon and anesthetist.  (+info)

Bone marrow harvesting using EMLA (eutectic mixture of local anaesthetics) cream, local anaesthesia and patient-controlled analgesia with alfentanil. (6/302)

Bone marrow harvesting (BMH) was performed on 40 consecutive allogeneic or autologous donors using EMLA (eutectic mixture of local anaesthetics), local anaesthesia (LA) and patient-controlled analgesia with alfentanil (PCA-A). The effect of alkalinizing the LA solution on reducing pain during LA infiltration in the presence of EMLA was also investigated. EMLA 10 g with occlusive dressing was applied to the harvest sites at least 60 min before BMH. The PCA device was programmed to deliver an intravenous loading dose of 15 microg/kg alfentanil, followed by a background alfentanil infusion of 0.05 microg/kg/min. Demand dose was 4 microg/kg and lockout time was 3 min. Donors were randomized to receive either alkalinized (n = 19) or non-alkalinized (n=21) LA solution (lignocaine 1% with 1:100000 adrenaline). While post-operative nausea and vomiting were the only side-effects, all donors in both groups reported satisfactory pain scores during LA infiltration and satisfactory overall intra-operative comfort scores. They completed BMH using either regimen successfully, found this technique acceptable and would recommend this form of anaesthesia to others. Alkalinizing the LA solution did not significantly improve the pain scores during LA infiltration in the presence of EMLA. In conclusion, BMH can be performed safely using EMLA, LA and PCA-A without major complications.  (+info)

Effects of propofol, propofol-nitrous oxide and midazolam on cortical somatosensory evoked potentials during sufentanil anaesthesia for major spinal surgery. (7/302)

Recording of cortical somatosensory evoked potentials (CSEP) enables monitoring of spinal cord function. We studied the effects of propofol, propofol-nitrous oxide or midazolam during sufentanil anaesthesia on CSEP monitoring during major spinal surgery. Thirty patients with normal preoperative CSEP were allocated randomly to one of the following anaesthesia regimens: propofol (2.5 mg kg-1 followed by 10-6 mg kg-1 h-1) with or without nitrous oxide, or midazolam (0.3 mg kg-1 followed by 0.15 mg kg-1 h-1) combined with sufentanil 0.5 microgram kg-1 h-1 in the propofol and midazolam groups, or 0.25 microgram kg-1 h-1 in the propofol-nitrous oxide group. CSEP were elicited by alternate right and left tibial posterior nerve stimulation and recorded before and after induction (15 min, 1, 2 and 3 h), and during skin closure. CSEP latencies were not significantly modified in the three groups. CSEP amplitude decreased significantly in the propofol-nitrous oxide group (from mean 2.0 (SEM 0.3) to 0.6 (0.1) microV; P < 0.05) but not in the propofol (from 1.8 (0.6) to 2.2 (0.3) microV) or midazolam (1.7 (0.5) to 1.6 (0.5) microV) groups. The time to the first postoperative voluntary motor response (recovery) delay was significantly greater in the midazolam group (115 (19) min) compared with the propofol and propofol-nitrous oxide groups (43 (8) and 41 (3) min, respectively). Consequently, the use of propofol without nitrous oxide can be recommended during spinal surgery when CSEP monitoring is required.  (+info)

Anaesthetic effects of pregnanolone in combination with allopregnanolone, thiopental, hexobarbital and flurazepam: an EEG study in the rat. (8/302)

The anaesthetic interactions of the steroid, 3 alpha-hydroxy-5 beta-pregnan-20-one, in male rats were investigated in different fixed binary combinations with the steroid allopregnanolone (3 alpha-hydroxy-5 alpha-pregnan-20-one), two barbiturates (thiopental and hexobarbital) and the benzodiazepine, flurazepam. Anaesthetic effects were determined using an EEG threshold method. Interactions were assessed using an isobolographic method. The interaction between the two steroids, pregnanolone and allopregnanolone, showed an anaesthetic effect significantly less than additive (antagonistic). The interactions between pregnanolone and the two barbiturates and the benzodiazepine showed an anaesthetic effect significantly greater than additive (potentiation) in all tests performed. These results could be explained by a pharmacodynamic interaction at the hypothetical GABA-benzodiazepine-barbiturate-steroid complex in the CNS.  (+info)

The interaction index has been discussed by several authors, such as Berenbaum (9), Tallarida (14), and Meadows and colleagues (15). The definition of the interaction index coincides with Chou and Talalays definition of the combination index for mutually exclusive drugs, published in 1984 (16). The field of drug combination research spans more than 100 years and has been addressed within many disciplines. Chou and Talalays seminal article has made important contributions and has been widely cited in the literature. However, this article was not the first nor the only one that generates concepts supporting Eqs. 1 and 2 and applies these equations to study drug interactions. Lee and colleagues directed the reader to reviews of these methods, with proper citation of the appropriate references therein (17), and derived the confidence interval estimation for the interaction index and compared its performance with four methods based on response surface models. Although several equations are indeed ...
Atıf İçin Kopyala Toklu S., Iyilikci L., Gonen C. , Ciftci L., Gunenc F., Sahin E., et al. European journal of anaesthesiology, cilt.26, ss.370-6, 2009 (SCI İndekslerine Giren Dergi) ...
Application of A-line autoregressive model with exogenous input index during the wake-up test in spinal surgery under propofol-remifentanil anaesthesia.:
The increase of Corrected QT (QTc) interval is associated with age. It is known that most inhalation anesthetics or intravenous anesthetics can influence the QTc. In addition, tracheal intubation during induction can stimulates sympathetic activity, which, as a results, prolong the QTc interval. Therefore, the aim of study is to find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients ...
TY - JOUR. T1 - Visual acuity and pupillary reactions after peribulbar anaesthesia. AU - Talks, S.J.. AU - Chong, N.H.. AU - Gibson, J M. AU - Francis, I.R.. PY - 1994. Y1 - 1994. N2 - The effect of peribulbar anaesthesia on optic nerve function in 20 patients, before and after cataract surgery, was measured. All the patients had decreased visual acuity. Five (25%) had no perception of light. Seventeen (85%) developed a relative afferent pupil defect (RAPD). No patients saw the operating instruments. Seven (35%) had improved visual acuity immediately postoperatively. Patients should be warned that they may lose vision completely on being given a peribulbar anaesthetic; however their vision will improve, but not necessarily immediately, postoperatively. Examination for an RAPD is a good method of providing reassurance that the operating instruments will not be seen.. AB - The effect of peribulbar anaesthesia on optic nerve function in 20 patients, before and after cataract surgery, was measured. ...
A Quatro sensor (Aspect Medical Systems, Newton, MA) was mounted on the forehead according to the manufacturers guidelines, with another Quatro sensor mounted ipsilaterally according to Shiraishi et al .4 proposed occipital placement. The occipital process was considered the midline guide point with electrode 1 placed few centimeters cranially, electrodes 2 and 4 placed slanting, and electrode 3 placed laterally (fig. 1). The Quatro sensors were connected to two BIS-Vista™ monitors with the clocks synchronized to the exact "hour: minute: second." The raw electroencephalography signals were band-pass filtered to 2-70 Hz and processed in real time using BIS-Vista™ version 1.4 algorithm. In addition, the BIS-Vista™ monitor calculates the electromyography power in the 70-110 Hz frequency band displayed in decibels. BIS recordings were started after verifying a signal quality index more than 95% and electrodes impedance less than 5 kΩ. With the help of the USB-A port, electroencephalographic ...
BACKGROUND: The aepEX Plus monitor (aepEX) utilizes a mid-latency auditory evoked potential-derived index of depth of hypnosis (DoH). OBJECTIVE: This observational study evaluates the performance of the aepEX as a DoH monitor for pediatric patients receiving propofol-remifentanil anesthesia. METHODS: aepEX and BIS values were recorded simultaneously during surgery in three groups of 25 children (aged 1-3, 3-6 and 6-16 years). Propofol was administered by target-controlled infusion. The University of Michigan Sedation Scale (UMSS) was used to clinically assess the DoH during emergence ...
ABSTRACT: Response surface methodology based on a 3-variable, 5-level central composite rotatable design matrix was used to optimize the synthesis. The influence of selected variables, namely, enzyme/substrate (E/S) ratio, substrate concentration, and temperature was investigated. E/S ratio and temperature had a strong effect on esterification, while substrate concentration did not. Reaction time did not show significant effect on ester yields, and conversions could be completed in less than 24 h. The response surface model has been found to describe the experimental results adequately. Product yield at optimum conditions (24 g/mol E/S ratio, 1.5 M substrate concentration 20 °C) was 1.4 M, representing 93% conversion, which is in good agreement with the predicted one. ...
My preliminary communication to the Lancet was published in 1961. While according to dictionary definition I was the inventor of a premixed N2O/O2 gas mixture, subsequently called Entonox, BOC did not involve me with the patent. I was too unsophisticated for the matter even to enter my mind at that time. It is worth noting that BOC avoided listing the first published paper on premixed gas (in the Lancet) in their promotional booklet, published in September 1970, called the "Entonox Digest". The digest was a 35 page summary of articles, correspondence and papers. There were extracts of various publications in the medical literature on the clinical uses of Entonox ...
Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ...
The clinical studies demonstrate more powerful analgesic effect among female to both μ- and κ-opioid agonist (Fillingim et al. 2004). The antitussive effect of opioid is mediated predominantly by μ-, κ-opioid receptors (Kamei J. 1996). Therefore, the investigators hypothesized that there are sex differences in the antitussive responses to opioid.. It has been reported that target-controlled infusion (TCI) of remifentanil can reduce cough against endotracheal tube during emergence from general anesthesia. Some studies, reporting the EC50 and EC95 of remifentanil in effect-site TCI for preventing cough during emergence in different sex and surgeries (B. Lee et al. 2009, E.M.Choi et al. 2012), showed differences in EC50 and EC95.. The purpose of this study was to find out EC50 and EC95 of remifentanil in effect-site TCI for preventing cough during emergence in each sex and to evaluate whether there were sex differences in EC50 and EC95 of remifentanil in effect-site TCI or not. ...
What is a eutectic mixture? Eutectic comes from the Greek eutektos for "easily melted"(any resemblence to tectonic is, I believe, purely accidental - tectonic also comes from the Greek, but for building, not melting!). An eutectic mixture is one in which the melting point of the mix is lower than the melting point of either of the components. The binary phase diagram has a "eutectic point". EMLA is a mixture of equal weights of lidocaine and prilocaine, made into an emulsion ...
Teng WN, Tsou MY, Chen PT, Liou JY, Yu L, Westenskow DR, Ting CK, A desflurane and fentanyl dosing regimen for wake-up testing during scoliosis surgery: Implications for the time-course of emergence from anesthesia. J Formos Med Assoc 2017 Aug;116(8):606-612. Hsu WC, Orr J, Lin SP, Yu L, Tsou MY, Westenskow DR, Ting CK, Efficiency of oxygen delivery through different oxygen entrainment devices during sedation under low oxygen flow rate: a bench study. J Clin Monit Comput 2017 May 2;:. Chang KC, Orr J, Hsu WC, Yu L, Tsou MY, Westenskow DR, Ting CK, Accuracy of CO2 monitoring via nasal cannulas and oral bite blocks during sedation for esophagogastroduodenoscopy. J Clin Monit Comput 2016 Apr;30(2):169-73. Ting CK, Johnson KB, Teng WN, Synoid ND, Lapierre C, Yu L, Westenskow DR, Response surface model predictions of wake-up time during scoliosis surgery. Anesth Analg 2014 Mar;118(3):546-53. Yu L, Ting CK, Hill BE, Orr JA, Brewer LM, Johnson KB, Egan TD, Westenskow DR, Using the Entropy of Tracheal ...
MATA, Lukiya Birungi Silva Campos et al. Anestesia por infusão contínua de propofol associado ao remifentanil em gatos pré-tratados com acepromazina. Rev. Ceres [online]. 2010, vol.57, n.2, pp.198-204. ISSN 0034-737X. https://doi.org/10.1590/S0034-737X2010000200010.. O presente trabalho avaliou a associação anestésica do propofol, um anestésico geral de ação ultracurta e metabolismo rápido, ao remifentanil, opioide de grande poder analgésico, que potencializa os anestésicos gerais. O objetivo principal foi desenvolver um protocolo anestésico de uso intravenoso, por infusão contínua, que proporcione conforto ao paciente, segurança, com grande relaxamento muscular e analgesia em gatos submetidos a cirurgias eletivas como a ovariosalpingoisterectomia e orquiectomia. Foram utilizados 30 gatos, aleatoriamente distribuídos em 3 grupos de 10 animais. Em todos eles realizou-se a tranquilização com acepromazina (0,1 mg/kg, IM) e indução anestésica com propofol (6 mg/kg, IV). No ...
The combination midazolam-remifentanil presented a lower synergistic effect compared with propofol-remifentanil. The first fact documented a mean BIS of 62.5 +3 vs. 64.7 +4 midazolam-remifentanil association and has finally, although sporadic, incidents of desaturation content and never , 30%. The evaluation of the kinetic values of BIS, the interesting fact that emerges concerns the values, 70, which represented a significant predictor in the study to better recovery of consciousness, which has helped the fast-traking ongoing day-surgery. ...
Neuro-anesthetic contri- bution to the impedance of complications caused nearby perfunctory cerebral retraction: concept of a chemical thought retractorAge-at-death diagnosis and firmness of life-history param- eters past incremental lines in vulnerable dental cementum as an fingering helpDispensation of N2 O alone or adding it to a fentanyl-midazolam anes- thetic ,,05] or a propofol-remifentanil anesthetic did not interchange the BIS in rhyme study ,,06]If epidemiological statistics put up with inferences about clinical data, 2029 3039 4049 5059 Grow older 0 5 10 15 20 25 30 35 40 45 Men Women Ubiquity(%) 6069 ,70 REPRESENTATION 5.1 Age-specific ubiquitousness of metabolic syndrome ,a href=http://eiendomnorge.no/wp-content/notations/c/purchase-fluoxetine-online-no-rx/,purchase fluoxetine 10mg with visa,/a,. The convert an eye to developing engagement amelioration plans in the direction of each core program involves realization of an corroboration reassessment hardened to notify the phenomenon ...
A eutectic is a mixture that contains two or more components in proportions that allow them to solidify at the same temperature...
Malling 26 was bred at East Malling from a cross between M-9 and the very vigorous rootstock M-16 (Metziner Ideal). A virus-indexed EMLA clone was introduced by East Malling in 1969 / 1970.
This meeting will highlight and detail the development obstacles and features of propofol that have led to its wide range of applications.
Leser om anestesimidler blant annet propofol. Der står det misbruk og avhengighet av propofol (først og fremst hos helsepersonell). Ante ikke at noen ...
Who knew after having our coffee this morning we would end up at the Auto Club Speedway for the Petty Driving Experience....HOLY SHIT! is what I thought when Celi call this morning and asked how Marco was doing...I told her he was feeling better slowly but surely. She asked if I thought he would be willing to meet at the track and I told her I didnt know. So I went to ask Marco what he thought and he said YES! Well we left the house like bats out of hell ...
BACKGROUND We evaluated the anesthetic efficacy and the postoperative analgesic effects of 0.75% levobupivacaine versus 0.75% ropivacaine for peribulbar anesthesia in patients undergoing primary vitreoretinal surgery. METHODS We investigated 120 patients subjected to vitreoretinal surgery under peribulbar anesthesia. They were randomized into two equal groups according to the local anesthetic (LA) used, namely, 0.75% levobupivacaine or 0.75% ropivacaine, both with the addition of hyaluronidase. Nerve block was carried out by injection of 5-7 mL of the LA using single injection percutaneous peribulbar anesthesia with a short needle. RESULTS When compared with 0.75% ropivacaine, 0.75% levobupivacaine provided more successful akinesia at 10 min after block (P=0.026), fewer supplementary injections (P=0.026), and less volume (mL) was used (P=0.031). Also, levobupivacaine provided significantly longer motor block duration (342±27 min versus 206±40 min, P=0.001) and significantly longer sensory block
The aim of our study is to see if a new combination of anaesthetic drugs results in a better long-term developmental outcome than the current standard of care
SIMONI, Ricardo Francisco; PEREIRA, Antônio Márcio Sanfim Arantes; BOREGA, Renato dos Santos and SIMOES, Daniel Caldeira Pereira. Remifentanil versus Sufentanil em infusão contínua em intervenções cirúrgicas videolaparoscópicas: estudo comparativo. Rev. Bras. Anestesiol. [online]. 2008, vol.58, n.3, pp.193-201. ISSN 0034-7094. http://dx.doi.org/10.1590/S0034-70942008000300001.. JUSTIFICATIVA E OBJETIVOS: A infusão contínua (IC) de remifentanil na técnica de anestesia venosa total é prática comum. Já o sufentanil em IC para cirurgias de curta/média duração tem sido pouco utilizado. O objetivo desse estudo foi comparar duas técnicas de anestesia venosa total, utilizando remifentanil ou sufentanil em IC, quanto ao comportamento anestésico no intra-operatório e às características da recuperação anestésica em pacientes submetidos à videolaparoscopia. MÉTODO: Participaram desse estudo 60 pacientes divididos em 2 grupos iguais (GR e GS). O GR foi induzido com remifentanil IC ...
AbstractFor a commercially viable recombinant intracellular protein production process, efficient cell lysis and protein release is a major bottleneck. The recovery of recombinant protein, cholesterol oxidase (COD) was studied in a continuous bead milling process. A full factorial Response Surface Model (RSM) design was employed and compared to Artificial Neural Networks coupled with Genetic Algorithm (ANN-GA). Significant process variables, cell slurry feed rate (A), bead load (B), cell load (C) and run time (D), were investigated and optimized for maximizing COD recovery. RSM predicted an optimum of feed rate of 310.73 mL/h, bead loading of 79.9% (v/v), cell loading OD600 nm of 74, and run time of 29.9 min with a recovery of ~3.2 g/L. ANN coupled with GA predicted a maximum COD recovery of ~3.5 g/L at an optimum feed rate (mL/h): 258.08, bead loading (%, v/v): 80%, cell loading (OD600 nm): 73.99, and run time of 32 min. An overall 3.7-fold increase in productivity is obtained when compared to a batch
The total intravenous anesthesia (TIVA) is a commonly used technique in humans and has been instituted in anesthesia of small animals. The use of this technique only became popular in the last decade, due to lack of drugs ...
Detailed drug Information for remifentanil Intravenous. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
A Moderate Drug Interaction exists between Allfen CX and remifentanil. View detailed information regarding this drug interaction.
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Notes: Production, means the output of Propofol Revenue, means the sales value of Propofol This report studies Propofol in Global market, especially in Nor
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TY - JOUR. T1 - Menthol-based eutectic mixtures. T2 - Hydrophobic low viscosity solvents. AU - Ribeiro, Bernardo D.. AU - Florindo, Catarina. AU - Iff, Lucas C.. AU - Coelho, Maria A Z. AU - Marrucho Ferreira, Isabel Maria. PY - 2015/9/10. Y1 - 2015/9/10. N2 - Inspired by one of the major problems in the pharmaceutical industry, we advantageously used the formation of eutectic mixtures to synthesize new solvents. The aim of this work is to identify low viscosity, cheap, biodegradable and hydrophobic eutectic solvents from natural resources. Consequently, novel eutectic mixtures based on DL-menthol and naturally occurring acids, namely pyruvic acid, acetic acid, L-lactic acid, and lauric acid, were synthesized and are here reported for the first time. The obtained DLmenthol-based eutectic mixtures were analyzed using NMR and FTIR spectroscopy in order to check their structures and purities and to confirm the interaction of the two compounds leading to the eutectic formation. Important solvent ...
This project was designed to compare the dose requirements and the development of tolerance on the sedative/analgesic effect of propofol versus propofol plus remifentanil administered in rabbits under prolonged mechanical ventilation (PMV).. Eight male, clinically healthy New Zealand White rabbits were intubated under xylazine-ketamine-isoflurane anesthesia. After isoflurane discontinuation, the animals received either propofol (group P, n=4) or propofol plus remifentanil (group P/R, n=4) by continuous intravenous infusion for a maximum period of 38 hours. Arterial pressure (AP), heart rate (HR), respiratory rate (RR), electrocardiograph (ECG) and spO2 were continuously measured while arterial blood gases were analysed periodically. Initial doses were adjusted in order to achieve adequate level of sedation and analgesia based on reflexes, HR, arterial pressure and attempt for spontaneous breathing. Tolerance on the sedative/analgesic effect of the agents was indicated by the increase of their ...
No definitive outcomes study has explored whether administering a total intravenous anesthetic via TCI or with conventional continuous infusion rates impacts emergence. One might hypothesize that if administering a lengthy anesthetic, TCI would provide a more economical anesthetic and avoid unnecessary drug delivery that would perhaps delay emergence. Figure 30-1 presents a simulation of 2 intravenous techniques: one using TCI and the other set infusion rates for 2, 4, 6, and 8 hours. Both approaches used a high-dose remifentanil and low dose propofol technique. In fact the TCI target effect-site concentrations were selected to be near the effect-site concentrations that resulted from propofol infusions of 100 mcg/kg/min and remifentanil 0.2 mcg/kg/min. In general, with increasing duration of the anesthetic, the simulation predicted the time to emergence would become longer. Time to emergence was defined as the time required for the model of loss of responsiveness to predict that only 1 out of ...
The aim of this study was to determine the combined effects of slightly acidic electrolyzed water SAEW (pH range 5.06.5, oxidationreduction potential 6501000 mV, available chlorine concentration 1080 mg/L) containing 0, 15, and 30 ppm chlorine and 0, 50, and 100 min of ultrasound US (37 kHz, 380 W) using the central composite design (CCD) on the reductions of Escherichia coli and Vibrio parahaemolyticus (initial value, approximately 67 log10 colony forming unit (CFU) of E. coli or V. parahaemolyticus/g) and the sensory properties on freshly sliced shad (Konosirus punctatus), in comparison with SAEW or US alone. Another aim was to develop the response surface model for E. coli and V. parahaemolyticus in the shad treated with the combination of SAEW and US. Single treatments with SAEW (chlorine 15 ppm), SAEW (chlorine 30 ppm), or US for 50 min caused a much-less-than-1-log10 reduction in the number of both E. coli and V. parahaemolyticus in the shad. In contrast, the combination of SAEW (15 or 30 ...
Background and study aims : In endoscopic procedures, propofol can be safely administered either alone or in conjunction with remifentanil. The aim of the study is to compare the effects of the administration of propofol alone and the administration of remifentanil in addition to propofol on patient and endoscopist satisfaction, preoperative hemodynamic response, and propofol consumption. ...
METHODS: We recruited 15 patients. For each patient of our study we defined a skin area of 3 cm2 from two forearms: on one side, we used skin needling first and immediately thereafter applied the EMLA in occlusion for 60 minutes; on the other one, we only applied EMLA in occlusion for 60 minutes. Then, pain was induced in each patients forearm by introducing a 27 G needle into the skin 4 mm deep three times. Lastly, pain sensation measures were registered and a middle value was calculated ...
EMLA Patch (lidocaine 2.5% and prilocaine 2.5%) is a topical anesthetic which causes a temporary numbness to the skin area. This combination product contains two medications: lidocaine and prilocaine. Both of these medications belong to the family of topical anesthetics. Together, they are used to reduce the pain or di
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4. Kurita TUraoka MMorita KSuzuki MMorishima YSato S: Influence of haemorrhage on the pseudo-steady-state remifentanil concentration in a swine model: a comparison with propofol and the effect of haemorrhagic shock stage. Br J Anaesth 107:719-7252011. ...
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... - Key words: Intravenous anesthesia, remifentanyl, propofol, infusion pump, .. Aguilera L. Conceptos básicos de farmacocinética farmacodinámia en TIVA.
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Anesthetics Sedation Twilight sleep Moby's Medical Dictionary. Elsevier. "Combined analgesic/neuroleptic activity in N- ... an anesthetic process that involves combining a major neuroleptic tranquilizer/antipsychotic with a potent opioid analgesic to ... Efforts were also made to develop compounds which combined both types of activity in a single molecule. Neuroleptanalgesia ...
Treatment consists of several such anesthetic injections, sometimes combined with corticosteroids. Such an approach yields ... Confirmation of a diagnosis of ACNES is warranted using an abdominal wall infiltration with a local anesthetic agent near the ... This involves a repeated exploration combined with a posterior neurectomy. This procedure has been shown to be beneficial in 50 ...
Suprascapular with or without Axillary Nerve Blockade Combined with Local Anesthetic Wound InfiltrationEdit. Since the ... data on combined usage of general anesthesia and interscalene blocks are limited. Some indications for combined anesthesia ... A mixture of short and long-acting local anesthetics is used to prolong the duration as well as reduce the onset of the nerve ... The following anesthetics are methods commonly used to assist with post-operative shoulder replacement pain management: ...
... a combined anesthetic and medicine. Other Ganymedian life-forms include the whale-like Gamma Rorqual, the tentacled land leet, ...
Injections of local anesthetic, sometimes combined with steroids, into the muscles (e.g. the temoralis muscle or its tendon) ... Local anesthetics may provide temporary pain relief, and steroids inhibit pro-inflammatory cytokines.[49] Steroids and other ... This may occur during dental treatment, with oral intubation whilst under a general anesthetic, during singing or wind ...
Anesthetics were not regularly used in medicine or dentistry until decades after Davy's death. Davy threw himself energetically ... At one point the gas was combined with wine to judge its efficacy as a cure for hangover (his laboratory notebook indicated ... His respiration of nitric oxide which may have combined with air in the mouth to form nitric acid (HNO3), severely injured the ...
Clinical local anesthetics belong to one of two classes: aminoamide and aminoester local anesthetics. Synthetic local ... Anesthetists sometimes combine both general and local anesthesia techniques. The following terms are often used interchangeably ... Conduction anesthesia encompasses a great variety of local and regional anesthetic techniques. A local anesthetic is a drug ... lack of anesthetic effect due to infectious pus such as an abscess. Local pain management that uses other techniques than ...
... and a weak anesthetic. As well as nappy rash, it can also be used to treat eczema, bedsores, acne, minor burns, surface wounds ... and combined with, Actavis plc. On March 17, 2015, Actavis completed the acquisition of Allergan, creating a $23 billion ...
The Records of the Three Kingdoms and the Book of the Later Han both credit him as creating this anesthetic during the Eastern ... The name mafeisan combines ma (麻; "cannabis; hemp; numbed"), fei (沸; "boiling; bubbling") and san (散; "break up; scatter; ... The name Hua Tuo combines the Chinese surname Hua (華, literally "magnificent; China") with the uncommon Chinese given name Tuo ... He used a general anaesthetic combining wine with a herbal concoction called mafeisan (麻沸散; literally "cannabis boil powder"). ...
... anesthetic effect of barbiturates in high doses when used in anesthetic concentration. Barbituric acid was first synthesized ... The middle two classes of barbiturates are often combined under the title "short/intermediate-acting." These barbiturates are ... However, barbiturates are still used as anticonvulsants (e.g., phenobarbital and primidone) and general anesthetics (e.g., ... then the combined effects of the drugs increase the channels overall function by 900%, not 600%). The longest-acting ...
When combined together into the holoprotein peditoxin, even low doses resulted in anaphylaxis-like shock and death. UT841, a ... and anesthetic coma. At higher doses it resulted in convulsions and death. Pedin itself is non-toxic, but it magnifies the ...
About his dental research a long list of inventions have made him famous among professionals of his time, such as combine ... It was published in 1875 under the title "The air an anesthetic" and presented at the Franklin Institute. Bonwill invented an ... The Bonwill Brace is a support bracket - by combining two brackets, which includes two adjacent teeth. Erich Göhler, Bonwill ...
It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined ... Applying an oral anesthetic and consuming beverages before going to bed can be particularly hazardous. The topical use of ... Overapplication of oral anesthetics such as benzocaine can increase the risk of pulmonary aspiration by relaxing the gag-reflex ... Benzocaine, sold under the brand name Orajel among others, is an ester local anesthetic commonly used as a topical pain ...
It should therefore be used with caution if combined with other drugs that affect blood pressure, such as sedatives and ... anesthetic drugs. Isoxsuprine is most commonly used to treat hoof-related problems in the horse, most commonly for laminitis ...
... (/ˈpraɪləˌkeɪn/) is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Löfgren. In ... It is also often combined with lidocaine as a topical preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for ... People with pseudocholinesterase deficiency may have difficulty metabolizing this anesthetic. It is given as a combination with ... "Topical Anesthesia Use in Children: Eutectic Mixture of Local Anesthetics". Medscape.com. Retrieved 2014-01-07. The United ...
... at anesthetic doses in 1973, and the drug was abandoned as a general anesthetic in the late 1970s. In 1999, the manufacturer ... The biodegradation of methoxyflurane produces inorganic fluoride and dichloroacetic acid (DCAA). The combined effects of these ... It was found to be necessary to administer an intravenous anesthetic agent such as sodium thiopental to ensure a smooth and ... It is a powerful analgesic agent at well below full anesthetic concentrations. Because of its low volatility and very high ...
If vasoconstriction is desired for a procedure (as it reduces bleeding), the anesthetic is combined with a vasoconstrictor such ... Benzoyl-CoA then combines the two units to form cocaine. The biosynthesis begins with L-Glutamine, which is derived to L- ... This, combined with crop reductions in Bolivia and Peru, made Colombia the nation with the largest area of coca under ... There is also evidence that these cultures used a mixture of coca leaves and saliva as an anesthetic for the performance of ...
The leaves or extracts from them are used to heal wounds and as a local anesthetic. Extracts and leaves have been used to treat ... The herb is very bitter and is generally combined with a sweetener. Across Southeast Asia, and especially in Thailand in the ...
... is synthesized by combining dibromofluorescein with mercuric acetate and sodium hydroxide or alternatively, through ... the majority of alkaloid salts and most local anesthetics.[8] ... action of the mercuric acetate upon (or combining with) sodium ...
When combined therapy is contemplated, the dose should be reduced of one or both agents. Hydromorphone is a semi-synthetic μ- ... CNS depressants may enhance the depressant effects of hydromorphone, such as other opioids, anesthetics, sedatives, hypnotics, ... Simultaneous use of hydromorphone with other opioids, muscle relaxants, tranquilizers, sedatives, and general anesthetics can ...
John Arderne (1307-1392) was an English physician and surgeon who invented his own anesthetic that combined hemlock, henbane, ...
Currently, data on combined usage of general anesthesia and interscalene blocks are limited. Some indications for combined ... A mixture of short and long-acting local anesthetics is used to prolong the duration as well as reduce the onset of the nerve ... One example of a commonly used regional anesthetic is an interscalene brachial plexus block and it has been used in a number of ... The following anesthetics are methods commonly used to assist with post-operative shoulder replacement pain management: Three ...
Neuraxial (regional) anesthetic and analgesia techniques: (e.g. epidural, spinal, combined spinal-epidural) are used most ... Following Morton's use of ether as an anesthetic, James Simpson conducted his own obstetric anesthetic trial on January 19, ... The inhalation of anesthetic agents do not affect the act of labor or the mechanism by which uterine contractions occur, but ... With this finding, along with the statistical records of safely executed anesthetic administrations, the medical opposition to ...
Epinephrine/adrenaline is frequently combined with dental and spinal anesthetics and can cause panic attacks in susceptible ... Local anesthetics[edit]. Adrenaline is added to injectable forms of a number of local anesthetics, such as bupivacaine and ... Some of the adverse effects of local anesthetic use, such as apprehension, tachycardia, and tremor, may be caused by adrenaline ... Due to epinephrine's vasoconstricting abilities, the use of epinephrine in localized anesthetics also helps to diminish the ...
... is sometimes combined with opioids, especially ones of the open-chain class like methadone, dextropropoxyphene, and ... It possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Its antiemetic and antivertigo ... dipipanone (originally combined with meclizine's parent drug cyclizine, the brand name of this combination being Diconal). ...
Some herbal remedies can cause dangerous interactions with chemotherapy drugs, radiation therapy, or anesthetics during surgery ... of extravagant claims by the alternative medical community combined with inadequate media scrutiny and attacks on critics.[122] ...
Local anesthetic Drug Prilocaine Hcl material manufacturer wholesaler at steroidliquid.com, Pain RELIEF with Good Effect. ... Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting ... It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment ... Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or ...
CAUTION! Sedative and anesthetic drug dosages for African elephants often vary from those for Asian elephants. Do not assume ... c) 0.1 mg/kg IM for Asian elephants; if combined with other drugs, dose can be reduced by up to 50% (Nayar, 2002). ... Other CNS depressant agents (barbiturates, narcotics, anesthetics, etc.) may cause additive CNS depression if used with ... b) 40-60 mg acepromazine/metric ton (0.04-0.06 mg/kg) combined with 100 mg xylazine/metric ton for Asian elephants (Cheeran, et ...
Combined electrochemical nerve block reduced pain in 80% of patients with neuropathies and 50% of patients with intractable ... New Technique Combines Electrical Currents and Local Anesthetic for Pain Management. As Originally published by Practical Pain ... In addition, we have combined the new EST with local anesthetic injections (bupivacaine 0.25%) with clinical success. This ... Combined electrochemical nerve block reduced pain in 80% of patients with neuropathies and 50% of patients with intractable ...
Patient underwent combined right atrial thrombectomy and living donor liver transplantation (LDLT) in the same setting. ... Perioperative anesthesia management and perioperative concerns of two major combined procedures are discussed.... ... Perioperative anesthetic management of a combined right atrial thrombectomy with living donor liver transplantation. *. ... Patient underwent combined right atrial thrombectomy and living donor liver transplantation (LDLT) in the same setting. ...
Purpose : To determine the feasibility and safety of outpatient combined intracavitary and interstitial brachytherapy for ... Novel anesthetic technique for combined intracavitary and interstitial brachytherapy for cervix cancer in an outpatient setting ... "Novel anesthetic technique for combined intracavitary and interstitial brachytherapy for cervix cancer in an outpatient setting ... "Novel anesthetic technique for combined intracavitary and interstitial brachytherapy for cervix cancer in an outpatient setting ...
BACKGROUND AND OBJECTIVE: Combined (local and general) anaesthesia or Balanced (intravenous analgesics and inhalational ...
Receiving Set Combines Hearing Aid Radio October 26, 1946 by Science News ...
Anesthetics, Local. Anesthetics. Central Nervous System Depressants. Physiological Effects of Drugs. Sensory System Agents. ... A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation. This study has been ... Known drug sensitivity to amide-type local anesthetics. *Unlikely to understand or be able to comply with study procedures, for ... The study drug is a metered-dose anesthetic spray, which is being developed for the treatment of premature ejaculation (PE). ...
LA drugs are also often combined with other agents such as opioids for synergistic analgesic action.[1] Low doses of LA drugs ... List of local anesthetics. References[edit]. *^ Ryan, T (2019). "Tramadol as an adjunct to intra‐articular local anaesthetic ... of Wisconsin, Local Anesthesia and Regional Anesthetics *^ a b Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik ... A local anesthetic (LA) is a medication that causes absence of pain sensation. When it is used on specific nerve pathways ( ...
12093-20 COMBINED SPINAL/EPIDURAL 18G TUOHY/27G HIGH FLOW WHITACRE () kit NDC Code(s): 0409-1209-65, 0409-7241-61, 51688-9913-2 ... SEARCH RESULTS for: Amide Local Anesthetic [Drug Class] (2214 results) * Share : JavaScript needed for Sharing tools. Bookmark ...
... wherein the anesthetic comprises from about 0.5 to about 2.0% by weight of the composition, the composition further containing ... the composition containing a local parenteral anesthetic which in normal doses gives an acid pH of from about 2.5 to about 6.9 ... An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the ... Combined mixing syringe and container. US3978212 *. Dec 13, 1974. Aug 31, 1976. Chemo Drug Company. Electrolyte solutions ...
Our anesthesia group routinely performs 10-hour outpatient pediatric anesthetics for combined atresia-microtia ear ... 3 thoughts on "10-HOUR OUTPATIENT PEDIATRIC ANESTHETICS FOR COMBINED ATRESIA-MICROTIA (CAM) EAR RECONSTRUCTION" * bank post ... The surgical-anesthetic team to date has successfully performed the combined procedure on 55 patients, 90% of who were of the ... This combined atresia and microtia repair, requiring a total anesthetic time approaching ten hours, is a new procedure being ...
Pancoast Tumors and Combined Spinal Resections Andrew Kaufman, David Amar, Valerie W. Rusch ... Anesthetic Considerations for Infectious, Congenital, and Acquired Pulmonary Disorders Peter Slinger, Rebecca Jacob ...
Anesthetics, Local. Anesthetics. Central Nervous System Depressants. Physiological Effects of Drugs. Sensory System Agents. ... Anesthetics, Intravenous. Anesthetics, General. Central Nervous System Stimulants. Sympathomimetics. Autonomic Agents. ... The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain and Hemodynamic Changes Due to Propofol Injection. This ... Title: The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain Due to Propofol Injection in Patients Undergoing ...
... analgesics and anesthetics, explains this ACOG patient FAQ. ... Anesthetics: Drugs that relieve pain by loss of sensation.. ... They include the epidural block, spinal block, and combined spinal-epidural (CSE) block. The medication includes an anesthetic ... Breathing problems if the anesthetic affects your breathing muscles. *Numbness, tingling, or rapid heartbeat if the anesthetic ... The anesthetic drug is injected into the area around the nerves that carry feeling to the vagina, vulva, and perineum. Local ...
Combined spinal/epidural block, Combined spinal/epidural local anaesthetic block, Combined spinal/epidural local anesthetic ... combined spinal epidural anesthesia, Combined spinal/epidural local anesthetic block (procedure). ... Uses a combined injection of spinal (intrathecal) and Epidural Anesthesia. *Lower dose anesthetic (bupivicaine or ropivicaine) ... Local anesthetic epidural block, Local anesthetic epidural block, Epidural anesthesia (procedure), Epidural Block. ...
... Article information. ... Anesthetic management of combined heart-liver transplantation in a patient with ischemic cardiomyopathy and cardiac cirrhosis: ... Diaz GC, Renz JF, Nishanian E, Kinkhabwala M, Emond JC, Wagener G. Anesthetic management of combined heart-liver ... Herein, we describe the anesthetic management during the first combined heart-liver transplant (CHLT) performed in Korea. ...
Anesthetic injection system. US8425464. Jun 11, 2012. Apr 23, 2013. Carticept Medical, Inc.. Imaging-guided anesthetic ... 30, 1974 COMBINED IRRIGATOR, INJECTOR AND EVACUATOR [52] US. Cl. 32/40 R, 32/57 [51] Int. Cl. A61c 3/00 [58] Field of Search 32 ... Combined coaxial and bimanual irrigation/aspiration apparatus. US9468720. Nov 12, 2013. Oct 18, 2016. Allergan, Inc.. Injection ... n 30 A N APR 30 I974 3807LO48 SHEET u 0F 4 COMBINED IRRIGATOR, INJECTOR AND EVACUATOR RELATED APPLICATIONS This application is ...
Anesthetics, Combined / administration & dosage* * Anesthetics, Local / administration & dosage* * Antibodies / blood * Double- ...
Anesthetic, any agent that produces a local or general loss of sensation, including pain. Anesthetics achieve this effect by ... Not infrequently, general anesthetics are combined with drugs that block neuromuscular impulse transmission. These additional ... Anesthetic, also spelled anaesthetic, any agent that produces a local or general loss of sensation, including pain. Anesthetics ... General anesthetics. General anesthetics induce anesthesia throughout the body and can be administered either by inhalation or ...
Anesthetic Profile of Dexmedetomidine Identified by Stimulus-Response and Continuous Measurements in Rats. Cornelis J. J. G. ... Combined with previous results (Bol et al., 1997a), the data suggest that the proposed EEG measure may better reflect different ... Anesthetic Profile of Dexmedetomidine Identified by Stimulus-Response and Continuous Measurements in Rats. Cornelis J. J. G. ... Anesthetic Profile of Dexmedetomidine Identified by Stimulus-Response and Continuous Measurements in Rats. Cornelis J. J. G. ...
Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ability ... Anesthetics, Combined. Anesthetics, Local / pharmacology*. Animals. Cell Line. Chemistry, Pharmaceutical. Cornea / drug effects ... 0/Anesthetics, Combined; 0/Anesthetics, Local; 0/Quaternary Ammonium Compounds; 0/Sodium Channel Blockers; 15461-38-8/ ... PURPOSE: Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ...
Anesthetics, Combined / administration & dosage * Anesthetics, Local / administration & dosage * Attitude of Health Personnel ... Combined thoracic paravertebral plus pectoral nerve block with intra-operative sedation is a feasible technique for breast ... Combined Thoracic Paravertebral and Pectoral Nerve Blocks for Breast Surgery Under Sedation: A Prospective Observational Case ...
Anesthetics, Local / administration & dosage, pharmacology*, therapeutic use. Animals. Animals, Newborn. Bupivacaine / ... Local anaesthetic combined with wound cautery virtually abolished the cortisol response until at least 24 h after dehorning. ... CONCLUSION: Combining local anaesthesia with cautery of the amputation wounds substantially reduced the cortisol response until ...
0 (Anesthetics, Combined); 0 (Blood Glucose); CYS9AKD70P (Isoflurane); MR15E85MQM (Medetomidine); R60L0SM5BC (Midazolam); ...
  • Propofol delivered its anesthetic effects smoothly and safely, and people recovered quickly, with minimal grogginess, nausea, or other lingering unpleasantness. (laskerfoundation.org)
  • Propofol and local anesthetics carry a theoretical risk of arrhythmogenic potential in BrS patients, but clear evidence is lacking. (springer.com)
  • Toutefois, le fait d'être conscients de leur potentiel à induire des arythmies justifie que nous fassions preuve de prudence, particulièrement en ce qui touche aux perfusions de propofol. (springer.com)
  • The goals of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contraction. (hindawi.com)
  • The potency of the vasoconstriction in the endothelium-denuded aorta induced by local anesthetics is determined primarily by lipid solubility and, in part, by other physicochemical properties including potency and pKa. (hindawi.com)
  • In addition, the membrane disordering efficiency of local anesthetics corresponds to their potency [ 4 ]. (hindawi.com)
  • However, to our knowledge, the physicochemical property of local anesthetics that is primarily responsible for determining the local anesthetic-induced vasoconstriction potency has not yet been identified. (hindawi.com)
  • Therefore, the aims of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to determine which physicochemical property is principally involved in determining this potency in isolated rat aortic rings. (hindawi.com)
  • Anesthetic Care for Orthopedic Patients:Is There a Potential for Differences in Care? (asahq.org)
  • Small-dose intraspinal local anesthetics, when added to either epidural or intrathecal opioids, synergistically enhance the antinociceptive effects of the opioid dose, as demonstrated by isobolographic analysis (2) , likely because of inhibition of neuronal excitability. (lww.com)
  • Analyzed data includs demographics, classification of tumor, perioperative anesthetic management and monitoring approaches, IVC clamping time , vital signs during cardiopulmonary bypass(CPB), estimated blood loss (EBL), usage of blood products, hospitalization time and ICU time , as well as postoperative outcomes. (urotoday.com)
  • Multivariable analyses were conducted to identify the independent impact of choice of anesthetic on outcomes. (ovid.com)
  • Hidaka Y, Chiba-Ohkuma R, Karakida T, Onuma K, Yamamoto R, Fujii-Abe K, Saito MM, Yamakoshi Y, Kawahara H. Combined Effect of Midazolam and Bone Morphogenetic Protein-2 for Differentiation Induction from C2C12 Myoblast Cells to Osteoblasts. (mdpi.com)
  • Conclusions: The anesthetic management of Inferior vena cava (IVC) tumor thrombus is rather challenging.The preoperative evaluation with accurate classification of the tumor and the intraoperative intense monitoring of vital signs with appropriate reaction are the key points of anesthetic management for this kind of surgery. (urotoday.com)
  • Knowledge of the mechanism of action might enable the design, synthesis, and testing of improved anesthetics and the prevention of adverse events such as intraoperative awareness and postoperative cognitive dysfunction. (aspetjournals.org)
  • Some anesthetics have been rejected for therapeutic use because they form explosive mixtures with air, because of their excessive irritant action on the cells that line the major bronchioles of the lung , or because of their adverse effects on the liver or other organ systems. (britannica.com)
  • The perfect match of two OVDs for the entire surgery, provided in two seperate syringes or combined in one syringe. (zeiss.com)
  • However, many of these products can have serious and potentially harmful side effects when combined with medications prescribed during and after surgery, according to a review article in the Journal of the American Academy of Orthopaedic Surgeons (JAAOS). (bio-medicine.org)