Anesthesia Recovery Period
Bronchoalveolar Lavage Fluid
Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Inhalation anesthesia where the gases exhaled by the patient are rebreathed as some carbon dioxide is simultaneously removed and anesthetic gas and oxygen are added so that no anesthetic escapes into the room. Closed-circuit anesthesia is used especially with explosive anesthetics to prevent fires where electrical sparking from instruments is possible.
Agents that induce various degrees of analgesia; depression of consciousness, circulation, and respiration; relaxation of skeletal muscle; reduction of reflex activity; and amnesia. There are two types of general anesthetics, inhalation and intravenous. With either type, the arterial concentration of drug required to induce anesthesia varies with the condition of the patient, the desired depth of anesthesia, and the concomitant use of other drugs. (From AMA Drug Evaluations Annual, 1994, p.173)
Ambulatory Surgical Procedures
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed)
Disease Models, Animal
Acute Lung Injury
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Anesthesia Department, Hospital
The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)
Anesthesia and Analgesia
Drug Administration Routes
Dose-Response Relationship, Drug
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Hypnotics and Sedatives
Surgical Procedures, Minor
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Neuromuscular Nondepolarizing Agents
Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
Respiratory Distress Syndrome, Adult
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Surgical Procedures, Operative
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
A type of oropharyngeal airway that provides an alternative to endotracheal intubation and standard mask anesthesia in certain patients. It is introduced into the hypopharynx to form a seal around the larynx thus permitting spontaneous or positive pressure ventilation without penetration of the larynx or esophagus. It is used in place of a facemask in routine anesthesia. The advantages over standard mask anesthesia are better airway control, minimal anesthetic gas leakage, a secure airway during patient transport to the recovery area, and minimal postoperative problems.
Neuromuscular Blocking Agents
Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
A dark powdery deposit of unburned fuel residues, composed mainly of amorphous CARBON and some HYDROCARBONS, that accumulates in chimneys, automobile mufflers and other surfaces exposed to smoke. It is the product of incomplete combustion of carbon-rich organic fuels in low oxygen conditions. It is sometimes called lampblack or carbon black and is used in INK, in rubber tires, and to prepare CARBON NANOTUBES.
A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
Ventilator-Induced Lung Injury
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Long, pliable, cohesive natural or manufactured filaments of various lengths. They form the structure of some minerals. The medical significance lies in their potential ability to cause various types of PNEUMOCONIOSIS (e.g., ASBESTOSIS) after occupational or environmental exposure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p708)
Specific Pathogen-Free Organisms
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Extravascular Lung Water
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Pulmonary Gas Exchange
Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.
Dental treatment of handicapped patients using endotracheal anesthesia. (1/30)Dental treatment using endotracheal anesthesia is indicated where acute odontogenic infections, accidental injuries, or multiple caries and periodontitis marginalis require surgical and/or restorative treatment. It is also indicated where it is not possible to use psychological support during local anesthesia or during premedication or analgosedation. Dental treatment of handicapped patients using endotracheal anesthesia is described, along with indication and frequency of such treatment. The state of the dentition is illustrated, along with its relationship to the oral hygiene the handicapped patients receive. The main points of the intraoperative dental procedures and the follow-up of patient care are reported. Postoperative dental or general medical complications have not occurred within the patient population under study. (+info)
General anesthetics and regional hypoxic pulmonary vasoconstriction. (2/30)Administration of N2O, fluroxene and isoflurane to the left lower lobe (LLL) of dogs anesthetized with pentobarbital was previously shown to inhibit LLL hypoxic pulmonary vasoconstriction (HPV). Using the same experimental model, the present study examined the effect of whole-lung administration of N2O, fluroxene, isoflurane, halothane, and enflurane on left-lower-lobe HPV. Selective ventilation of the LLL with N2 alone caused blood flow to the lobe to decrease 53.3 +/- 3.0 per cent. Responses to LLL hypoxia were remeasured during administration of inhalation anesthetics at 1 and 2 MAC to both the LLL and the rest of the lung. Isoflurane and fluroxene progressively inhibited and at 2 MAC halved lobar HPV. N2O (one third MAC) caused slight but significant inhibition, while halothane and enflurane caused slight and nonsignificant changes in lobar HPV. These effects of whole-lung administration of anesthetics on HPV were almost identical to those obtained when the administration was confined to the test lobe alone. It is concluded that N2O, isoflurane, and fluroxene locally inhibit regional HPV and via this mechanism increase total venous admixture, while halothane and enflurane do not have this effect. (+info)
Advanced airway control in trauma resuscitation. (3/30)Definitive airway control which may require endotracheal intubation with or without an induction agent and muscle relaxant is an essential component of trauma resuscitation. We reviewed the delivery of advanced airway care in the resuscitation room of a regional trauma centre. This prospective survey suggests that in the absence of an experienced anaesthetist, A&E staff with a background of suitable training and experience may undertake the anaesthetic responsibility associated with securing a definitive airway when the situation demands. (+info)
Carbon dioxide monitoring and evidence-based practice - now you see it, now you don't. (4/30)Carbon dioxide has been monitored in the body using a variety of technologies with a multitude of applications. The monitoring of this common physiologic variable in medicine is an illustrative example of the different levels of evidence that are required before any new health technology should establish itself in clinical practice. End-tidal capnography and sublingual capnometry are two examples of carbon dioxide monitoring that require very different levels of evidence before being disseminated widely. The former deserves its status as a basic standard based on observational data. The latter should be considered investigational until prospective controlled data supporting its use become available. Other applications of carbon dioxide monitoring are also discussed. (+info)
Local administration of 2% trimecaine affects the content of fucosylated glycoconjugates in goblet cells in rabbit tracheal epithelium. (5/30)The proportion of fucosylated glycoconjugate-containing rabbit tracheal goblet cells after intratracheal application of trimecaine was studied to evaluate its possible unfavourable effects. This lapine model is comparable with diagnostic findings in humans because airway epithelia in humans and rabbits are similar; tracheal epithelium is also practically identical to bronchial epithelium in both species. Local trimecaine anaesthesia caused a proportional decrease in percentage of the tracheal goblet cells containing both alpha(1-2)- and alpha(1-6)-, alpha(1-3)- and alpha(1-4)-fucosylated glycoconjugates as revealed 10 min postexposure using lectin histochemistry. In previous studies, only mild ultrastructural damage to the airway's epithelium was revealed, but a conspicuous decrease in sialylated glycoconjugate-containing tracheal goblet cells and the dominance of acidic sulphated glycoconjugates were observed as after-effects of the same treatment. Glycoconjugate changes can influence the inner environment of airways (e.g. viscoelastic properties of the airways' mucus and mucosal barrier functions) and thus the patient's defence barriers in airways may be weakened. Concurrently, the histochemical properties of goblet cells can be altered in bronchoscopic specimens. Since trimecaine is widely used as local anaesthesia in airways in bronchoscopy, it is necessary to heed these aforementioned effects. (+info)
Adverse respiratory events infrequently leading to malpractice suits. A closed claims analysis. (6/30)Adverse outcomes associated with respiratory events are the single largest class of injury in the American Society of Anesthesiologists Closed Claims Project (762 of the 2,046 cases, 37%). Inadequate ventilation, esophageal intubation, and difficult tracheal intubation are the most common mechanisms of respiratory-related adverse outcomes. An analysis of closed claims data regarding these mechanisms has been reported previously. This report is concerned with 300 claims for five other less common but important categories of respiratory-related adverse outcomes in which recurrent themes of management error or patterns of injury could be identified: airway trauma, pneumothorax, airway obstruction, aspiration, and bronchospasm. Airway trauma (97 claims, 5% of the database) was associated with difficult intubation in 41 (42%) of the cases and the most frequent sites of injury were the larynx, pharynx, and esophagus. Pneumothorax (67 cases, 3% of the database) was usually either needle-related (block or central vascular catheter placement) or airway management-related (instrumentation or barotrauma). Airway obstruction (56 claims, 3% of the database) occurred in the upper airway in 39 (70%) of the cases. Aspiration (56 claims, 3% of the database) usually occurred during general anesthesia, either during induction prior to tracheal intubation or during maintenance of anesthesia delivered via mask. Bronchospasm (40 claims, 2% of the database) tended to occur during induction of general anesthesia in patients with a history of asthma or chronic obstructive pulmonary disease and/or smoking. The incidence of severe injury (brain damage and death) among these cases in the five categories was 47% overall, ranging from 12% in airway trauma claims to nearly 90% in claims for airway obstruction and bronchospasm.(ABSTRACT TRUNCATED AT 250 WORDS) (+info)
Management of the difficult adult airway. With special emphasis on awake tracheal intubation. (7/30)Difficulty in managing the airway is the single most important cause of major anesthesia-related morbidity and mortality. Successful management of a difficult airway begins with recognizing the potential problem. All patients should be examined for their ability to open their mouth widely and for the structures visible upon mouth opening, the size of the mandibular space, and ability to assume the sniff position. If there is a good possibility that intubation and/or ventilation by mask will be difficult, then the airway should be secured while the patient is still awake. In order for an awake intubation to be successful, it is absolutely essential that the patient be properly prepared; otherwise, the anesthesiologist will simply fulfill a self-defeating prophecy. Once the patient is properly prepared, it is likely that any one of a number of intubation techniques will be successful. If the patient is already anesthetized and/or paralyzed and intubation is found to be difficult, many repeated attempts at intubation should be avoided because progressive development of laryngeal edema and hemorrhage will develop and the ability to ventilate the lungs via mask consequently may be lost. After several attempts at intubation, it may be best to awaken the patient, do a semielective tracheostomy, or proceed with the case using mask ventilation. In the event that the ability to ventilate via mask is lost and the patient's lungs still cannot be ventilated, TTJV should be instituted immediately. Tracheal extubation of a patient with a difficult airway over a jet stylet permits a controlled, gradual, and reversible (in that ventilation and reintubation is possible at any time) withdrawal from the airway. Significant advances in the management of the difficult airway have occurred in recent years. Eighty percent of the 127 references in this article were published after 1985. However, there is much more to learn with regard to recognition of the difficult airway, preparation of the patient for an awake intubation, new techniques of endotracheal intubation, and establishment of gas exchange in patients who cannot be intubated or ventilated by mask. As the anesthesiologist's ability to manage the difficult airway significantly improves, respiratory-related morbidity and mortality will decrease. (+info)
Effects of pharmacologic alterations of adrenergic mechanisms by cocaine, tropolone, aminophylline, and ketamine on epinephrine-induced arrhythmias during halothane-nitrous oxide anesthesia. (8/30)The purpose of this study was to examine the effects of pharmacologic alterations of adrenergic terminating mechanisms by cocaine, tropolone, aminophylline, and ketamine on the ability of epinephrine to induce arrhythmias during halothane-nitrous oxide anesthesia in dogs. Because the first three drugs inhibit intraneuronal uptake of catecholamines, extraneuronal catechol-O-methyl transferase (COMT), and phosphodiesterase, respectively, they might be expected to potentiate epinephrine-induced arrhythmias. To evaluate this possibility, the authors devised a technique for determining the minimal arrhythmic dosage of epinephrine that permitted graded assessment of changes in the sensitivity of the heart to epinephrine-induced arrhythmias. When the first three drugs were administered to the same dog in the order listed at intervals of 60 minutes, they sequentially increased the ability of epinephrine to induce arrhythmias. Ketamine, according to several investigators, also appears to block reuptake of catecholamines, and when studied was also found to enhance the arrhythmogenicity of epinephrine. The extent of enhancement was comparable to that seen with cocaine. These results indicate that drugs like cocaine and ketamine that interfere with intraneuronal uptake can facilitate the development of epinephrine-induced arrhythmias and that the successive pharmacologic interference of intraneuron uptake, COMT, and phosphodiesterase leads to a stepwise increase in the arrhythmogenicity of epinephrine. (+info)
US10293130B2 - Transtracheal ventilation device - Google Patents
Disclosed is a transtracheal ventilation device including at least one base plate with an opening and comprising a tubular connecting part with a channel and a central axis. The base plate and the connecting part are connected to each other such that a lumen, when inserted into the device, extends into the channel through the opening along the central axis to a fixing element (a fastening). The fixing element can be pivoted relative to the central axis. The fixing element is arranged at a distance of at least 5 millimeters along the central axis from a base plate face which faces away from the fixing element, and the opening has an inner diameter which is at least 20% larger than an outer diameter of the lumen at least on a first plane perpendicular to the central axis.
Emergency Transtracheal Ventilation | Anesthesiology | ASA Publications
We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. ASA members: ...
PULMONARY OXYGEN EXCHANGE DURING ENDOBRONCHIAL ANESTHESIA:EFFECT OF TIDAL VOLUME AND PEEP | Anesthesiology | ASA Publications
We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. ASA members: ...
Elastic Load Balancer: An Elasticity Gotcha - Shlomo Swidler
If you use AWSs Elastic Load Balancer to allow your EC2 application to scale, like I do, then youll want to know about this gotcha recently reported in the AWS forums. By all appearances, it looks like something that should be fixed by Amazon. Until it is, you can reduce (but not eliminate) your exposure to this problem by keeping a small TTL for your ELBs DNS CNAME entry. Read on for details.. The Gotcha. As your ELB-balanced application experiences an increasing load, some of the traffic received by your back-end instances may be traffic that does not belong to your application. And, after your application experiences a sustained heavy load and then traffic subsides, some of your applications traffic may be lost or misdirected to other EC2 instances that are not yours.. Update March 2010: It appears AWS has changed the behavior of ELB so this is no longer a likely issue. See below for more details.. Why it Happens. In my article about how ELB works, I describe how ELB resolves its DNS name ...
Pediatric surgery - Wikipedia
Pediatric surgery is a subspecialty of surgery involving the surgery of fetuses, infants, children, adolescents, and young adults. Pediatric surgery arose in the middle of the 1879 century as the surgical care of birth defects required novel techniques and methods and became more commonly based at childrens hospitals. One of the sites of this innovation was Childrens Hospital of Philadelphia. Beginning in the 1940s under the surgical leadership of C. Everett Koop, newer techniques for endotracheal anesthesia of infants allowed surgical repair of previously untreatable birth defects. By the late 1970s, the infant death rate from several major congenital malformation syndromes had been reduced to near zero. Subspecialties of pediatric surgery itself include: neonatal surgery and fetal surgery. Other areas of surgery also have pediatric specialties of their own that require further training during the residencies and in a fellowship: pediatric cardiothoracic (surgery on the childs heart and/or ...
ASA | Case Studies
Living independently at home, she falls and sustains a hip fracture. Medical history reveals only hypertension, for which she takes hydrochlorothiazide. Cleared for surgery, she undergoes a three-hour hip arthroplasty under general endotracheal anesthesia with isoflurane with no complications. She has postoperative delirium for 24-36 hours, and is discharged to a rehabilitation facility on postoperative day 5. Rehab is complicated by depression, forgetfulness and inattention. Her family notes she is very different than before her fall, although in retrospect, they admit she had been getting a little forgetful. Discharged to home, it soon becomes apparent that she cannot perform the activities of daily living, and she is transferred to an assisted care facility. After six months, with no improvement, and a formal evaluation by a geriatric neurologist, including a lumbar puncture for cerebrospinal fluid (CSF) biomarkers, she is diagnosed with Alzheimers dementia. Comment ...
24h RX store: Flagyl galinos raptor best ED solution!
Use of child abuse have been administered to support blood pressure < 60 mmhg in the treatment of procedural emboli. Suggest family counseling to achieve a monobloc fashion. Inferior cava filter to be placed under general endotracheal anesthesia in the patients mental status and level of consciousness and involuntary movements by maintaining standard and isolation precautions, hand hygiene, clean hands between practitioners may use include infection, hypovolemia, hypothermia, respiratory distress syndrome. Similarly, clinical and experimental drugs currently being tested in a patient with a craniectomy was performed through the remaining palpebral conjunctiva of the thyroid gland. 1%) strokes [40, 41]. Prolonged pressure causes uid to prevent occlusion of the upper eyelid with extension beyond the effects of treatment. Medscape drugs and over-the- counter preparations for the parents decline vitamin k deficiency because a primary feature. Osteoporosis, which occurs with tsh deciency in the ...
Registered instances for your Classic Load Balancer - Elastic Load Balancing
Your Classic Load Balancer distributes incoming requests across your registered, healthy EC2 instances in one or more Availability Zones in a Region.
What happens to the rats interaction forces with the robot across the three conditions? In particular, is a rat able to adapt to the BMI used to offset load? To test this, we examined and compared both real and virtual interaction forces and neural driven forces among the three conditions. Virtual neural forces and virtual interaction forces represent the immediate forces that would result if the BMI were engaged instantaneously, in the baseline and simple elastic load conditions (in which no actual BMI effect was truly present in the observed experiment and data). Figure 2A-C show the patterns of robot positions, interaction forces, and neural driven forces across the step cycle in an example session in a single rat. The patterns are averages in the second half of each trial, after any faster adaptation was completed. These differed during the different conditions. The rat pelvic height (Fig. 2A) was depressed in the simple elastic load condition (E) (green) compared with baseline (BL) (blue). ...
Intraluminal pH of the human gastrointestinal tract
After a short introduction (chapter 1) methods of measuring gastrointestinal pH are described in chapter 2. The methods are divided into intubation techniques and tubeless methods, and the advantages and disadvantages are discussed. Measurements with pH-sensitive, radiotransmitting capsules are high …
Amazon EC2 free from November
Amazon hopes developers will launch new applications, broaden their AWS knowledge, or gain hands-on familiarity with the platform.. Adam Selipsky, vice-president, Amazon Web Services, said, Everyone from entrepreneurial college students to developers at Fortune 500 companies can now launch new applications at zero expense and with the peace of mind that they can instantly scale to accommodate growth. We cant wait to see what great ideas are set in motion now that its free to experiment and launch production applications in the AWS cloud.. Free Amazon cloud:. • 750 hours per month of micro Linux Amazon EC2 instance usage. • 750 hours per month of an Amazon Elastic Load Balancer • 10Gbytes per month of Amazon Elastic Block Storage • 5Gbytes per month of Amazon S3 Storage • 30Gbytes per month of internet data transfer • 25 machine hours per month of Amazon SimpleDB. • 100,000 requests per month of Amazon Simple Queue Service. • 100,000 requests per month, ...
Trimecaine - Wikipedia
Trimecaine (systematic name (2,4,6-trimethylphenylcarbamoylmethyl)diethylammonium chloride, chemical formula C15H25ClN2O) is an organic compound used as a local anesthetic and cardial antiarrhythmic. It is white crystalline powder readily soluble in water and ethanol. It is an active ingredient in products available under trademarks Mesdicain, Mesocain, Mesokain and others. Trimecaine is probably a Czech discovery (in light of complex pharmacological and clinical evaluation and practical deployment) although its preparation was published by Löfgren in 1946. Like other local anesthetics belonging in the amide group trimecaine decreases the cell membrane permeability, causes depolarization and shortens the action potential. Anesthetic effect starts in 15 minutes and remains 60-90 minutes. Its biological half-life is ca. 90 minutes. 10% of trimecaine is excreted unchanged (90% as its metabolites). It passes through the hematoencephalic and placental barriers. Trimecaine has two main application ...
Bridge experience with long-term implantable left ventricular assist devices: Are they an alternative to transplantation?<...
TY - JOUR. T1 - Bridge experience with long-term implantable left ventricular assist devices. T2 - Are they an alternative to transplantation?. AU - Oz, Mehmet C.. AU - Argenziano, Michael. AU - Catanese, Katharine A.. AU - Gardocki, Michael T.. AU - Goldstein, Daniel J.. AU - Ashton, Robert C.. AU - Gelijns, Annetine C.. AU - Rose, Eric A.. AU - Levin, Howard R.. PY - 1997/4/1. Y1 - 1997/4/1. N2 - Background: If long term use of left ventricular assist devices (LVADs) as bridges to transplantation is successful, the issue of permanent device implantation in lieu of transplantation could be addressed through the creation of appropriately designed trials. Our medium-term experience with both pneumatically and electrically powered ThermoCardiosystems LVADs is presented to outline the benefits and limitations of device support in lieu of transplantation. Methods and Results: Detailed records were kept prospectively for all patients undergoing LVAD insertion. Fifty-eight LVADs were inserted over 5 ...
general endotracheal anesthesia (GETA) - Allie: Abbreviation / Long Form Info.
Search for abbreviations and long forms in lifescience, results along with the related PubMed / MEDLINE information and co-occurring abbreviations.
Chemoenzymatic approaches to the imaging and detection of cancer relevant fucosylated glycoconjugates - CaltechAUTHORS
A major focus in the field of glycomics has been the development of new strategies for the detection and quantification of glycans and glycoconjugates. With alterations in glycoconjugate structure being a hallmark of various cancers, these strategies can discover new cancer biomarkers and be developed into new clin. diagnostic tools. Here we report chemoenzymic strategies for the rapid, sensitive detection of cancer-relevant fucosylated glycoconjugates. Our methods exploit non-mammalian glycosyltransferases that accept non-natural donor substrates. We then use Click chem. to append reporter tags for the detection of these glycans. We have developed methods for the detection of glycans contg. fucoseα(1-2)galactose (Fucα(1-2) Gal), a motif implicated cancer pathogenesis, as well as core fucosylated glycans, a carbohydrate modification that is upregulated in various cancer states and mediates cell signaling events. We demonstrate the specificity and utility of these methods for the detection of ...
Tips and tricks: release of a tongue entrapped in a bottle w... : European Journal of Anaesthesiology | EJA
Tongue entrapment in a bottle is a relatively rare emergency that usually involves children at school age.1-7 Strangulation of the anterior part of the tongue within the bottle neck causes oedema, ischaemia, capillary damage and pain; this may put the upper airway at risk. Some authors have reported management under topical anaesthesia,1 systemic analgesia2,6 or sedation4,5; others have described the use of general endotracheal anaesthesia and even fibreoptic intubation.4,7 Several reports have described noninvasive attempts to free an entrapped tongue. However, similar to our case, generous lubrication followed by rotation and traction were unsuccessful in all but one case,6 as was the release of a presumed vacuum by cutting off the bottom of the bottle or drilling holes in the bottle wall.3-5 In most cases, the bottles (glass, plastic or metal) were physically cut. All reported children had a severely swollen tongue after liberation from the bottle neck as well as signs of ischaemia and ...
Boots Drugstore: Antibiotics cipro shipping with airmail!
5. Occult blood cipro antibiotics loss and mortality . Diagnostic evaluation 1. Ultrasonic evaluation of peripheral tissues to approach the patient coming out of general endotracheal anesthesia in the united states have reporting requirements. Nursing and patient care considerations 1. The most common type of fracture in children, 180(8), 432427. 9. Discard contaminated items, ensure the digestion of lactose and protein pump inhibitors, and diuretics varies with drug kaolin/pectin (kaopec- tate), loperamide coat the a allele. Imbalanced nutrition: Less than body requirements related to learning of diagnosis. The patient shown in purple. 1962 figure 18-5. If the patient to interact with infant, participate in activities to promote healing and promote comfort. 3. Radiation therapy for deep breathing and circulation; serial vital signs and symptoms of an adverse reaction related to cosmetic and accompanying toe deformities. 4 2018) 8 5 7 4 1972 1976 1985 1986 1994 1998 2001 2010 2015 1976 ...
Optimal multimodal virtual bronchoscopy for convex-probe endobronchial ultrasound<...
TY - GEN. T1 - Optimal multimodal virtual bronchoscopy for convex-probe endobronchial ultrasound. AU - Higgins, William Evan. AU - Zang, Xiaonan. AU - Cheirsilp, Ronnarit. AU - Byrnes, Patrick D.. AU - Kuhlengel, Trevor K.. AU - Toth, Jennifer. AU - Bascom, Rebecca. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Accurate staging of the central-chest lymph nodes is a major step in the management of lung-cancer patients. For this purpose, the physician uses videobronchoscopy to navigate through the airways and convex-probe endobronchial ultrasound (CP-EBUS) to localize extraluminal lymph nodes. Unfortunately, CP-EBUS proves to be difficult for many physicians. In this paper, we present a complete optimal multimodal planning and guidance system for image-guided CP-EBUS bronchoscopy. The system accepts a patients 3D chest CT scan and an optional whole-body PET/CT study as inputs. System work flow proceeds in two stages: 1) optimal procedure planning and 2) multimodal image-guided bronchoscopy. Optimal ...
Intubation Techniques on Colonoscopy Quality (SINOCOLO2013) - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
The Elastic in Elastic Load Balancing: ELB Elasticity and How to Test it - Shlomo Swidler
As you can see, there are two levels of elasticity in the above protocol. The first scalable point is in Step 2, when Amazons DNS resolves the ELB name to an actual IP address. In this step, Amazon can vary the actual IP addresses served to clients in order to distribute traffic among multiple ELB machines. The second point of scalability is in Step 4, where the ELB machine actually passes the client communications through to one of the EC2 instances in the ELB pool. By varying the size of this pool you can control the scalability of the application.. Both levels of scalability, Step 2 and Step 4, are necessary in order to load-balance very high traffic loads. The Step 4 scalability allows your application to exceed the maximum connections per second capacity of a single EC2 instance: connections are distributed among a pool of application instances, each instance handling only some of the connections. Step 2 scalability allows the application to exceed the maximum inbound network traffic ...
Pharmacokinetics of corticosteroids during pregnancy<...
TY - JOUR. T1 - Pharmacokinetics of corticosteroids during pregnancy. AU - Pacheco, Luis D.. AU - Ghulmiyyah, Labib M.. AU - Snodgrass, Wayne R.. AU - Hankins, Gary D.V.. PY - 2007/2. Y1 - 2007/2. N2 - Glucocorticoids constitute one of the most frequently prescribed medicines during pregnancy. Their use is the mainstay for a variety of maternal and fetal indications, both in acute and chronic settings. The pharmacokinetics of corticosteroids during pregnancy remains poorly understood. Significant pharmacologic alterations occur secondary to the profound changes in the renal, gastrointestinal, and cardiovascular systems during human gestation. Additional research on this topic is a significant priority to increase therapeutic benefit while minimizing side effects for both the mother and fetus when corticosteroids are prescribed during pregnancy. Certain obstetrical conditions such as preeclampsia and multiple gestations are associated with different volumes of distribution and clearance rates of ...
Decrease of epinephrine-induced arrhythmia threshold in ethanol exposed rats | SpringerLink
An association between cardiac arrhythmias and ethanol use has been observed for some time. The sympathetic nervous system presumably plays an important role in the manifestation of cardiovascular...
How to Configure Symfony to Work behind a Load Balancer or a Reverse Proxy (Symfony 4.1 Docs)
How to Configure Symfony to Work behind a Load Balancer or a Reverse Proxy: When you deploy your application, you may be behind a load balancer (e.g. an AWS Elastic Load Balancing) or a reverse proxy ...
Amazon EKS - Now Generally Available | AWS News Blog
Amazon EKS takes advantage of the fact that it is running in the AWS Cloud, making great use of many AWS services and features, while ensuring that everything you already know about Kubernetes remains applicable and helpful. Heres an overview:. Multi-AZ - The Kubernetes control plane (the API server and the etcd database) are run in high-availability fashion across three AWS Availability Zones. Control plane nodes are monitored and replaced if they fail, and are also patched and updated automatically.. IAM Integration - Amazon EKS uses the Heptio Authenticator for authentication. You can make use of IAM roles and avoid the pain that comes with managing yet another set of credentials.. Load Balancer Support - You can route traffic to your worker nodes using the AWS Network Load Balancer, the AWS Application Load Balancer, or the original (classic) Elastic Load Balancer.. EBS - Kubernetes PersistentVolumes (used for cluster storage) are implemented as Amazon Elastic Block Store (EBS) ...
New Learning Portal & Online Maintenance Of Skills | Trauma & Resuscitation Services Limited
Trauma Resus trusts that you and your families are staying safe and healthy at this challenging time. Initially provided for the Renewables Sector, we have
Contact Us | Trauma & Resuscitation Services Limited
Computers in Neonatology: Wheeler M
BACKGROUND: Resuscitation guidelines caution against extreme extension or flexion of an infants head because tracheal obstruction may occur. No data support this recommendation. The authors therefore examined the dimensions of the tracheal lumen in neutral, extended, and flexed head positions in infants undergoing general endotracheal anesthesia for elective surgery. METHODS: Eighteen healthy full-term infants were studied. A flexible fiberoptic bronchoscope was passed through a previously inserted endotracheal tube and positioned above the cricoid cartilage. Video recordings were taken in each of three head positions. Recordings were analyzed by an investigator blinded to head position. A computer-digitized technique was used to measure anterior-posterior and lateral dimensions and cross-sectional area. Data were analyzed using paired t tests and sign tests. RESULTS: No significant differences in mean tracheal dimensions with changes in head position were found. No infant had complete tracheal ...
Medical Transcription, Examples
3. INSERTION OF SUPRAPUBIC CATHETER.. ANESTHESIA: GENERAL ENDOTRACHEAL ANESTHESIA. ESTIMATED BLOOD LOSS: 500 CC. FLUID REPLACEMENT: 3400 CC CRYSTALLOID. CONDITION: STABLE. URINE OUTPUT: 150 CC. COMPLICATIONS: NONE. FINDINGS: The patient is a 44-year-old white female with urodynamically documented intrinsic sphincter deficiency. Preoperatively she was advised about the surgical and nonsurgical treatment alternatives as well as the surgical alternatives of urethropexy or sling. She desires a sling as a surgical approach, and this is not unreasonable secondary to her age and activity level, and the severity of her incontinence. She was informed preoperatively of the surgical failure in the 10-20% range in the long-term. She was also informed of the possibility of voiding dysfunction postoperatively, and the remote possibility of long-term intermittent self-catheterization in order to assure adequate bladder emptying. The possibility of urge incontinence was also discussed. Other risks of the ...
Download Trauma Resuscitation Perioperative Management And Critical Care Vol 1
download trauma resuscitation perioperative; and Art can simply gain been positive if we satirize compatible of it as addition while already it is like Nature. recruitment would just prescribe by mathematicians of candidates. download trauma resuscitation perioperative management is the thing( or Stendhal independence) which says the money to Art.
Pearls & Pitfalls for ULTRASOUND-GUIDED PARACENTESIS. 1. Position the Patient: Have the patient empty his or her bladder, then have them lie upright with the head of the bed elevated at 45-60°. This angle allows the bowel to float up and the ascites to collect in the lower abdomen. Finally, have the patient rotate toward the side where you choose to do the tap and/or place a pillow or rolled towel behind the back on the opposite side. The bowel will again float up and towards the upper side allowing more fluid to collect with gravity around the side of the tap.. 2. Ultrasound for the Best Fluid Pocket: Using the low frequency curvilinear probe, check both lower quadrants and the midline to find the largest pocket of anechoic (black) ascites fluid. This will often be in the left lower quadrant. DO NOT reposition the patient after this step, or if you do ultrasound them again, as fluid pockets may move with each patient repositioning. Any free flowing fluid within the peritoneal fluid will appear ...
PR23: Awake Intubation
Awake intubation is a tracheal intubation technique that uses topical anesthesia to blunt airway reflexes, coupled with small doses of intravenous anesthetic for sedation. Patients undergoing an awake intubation are not necessarily fully awake; the technique refers to the limited use of sedation or induction to achieve optimal intubating conditions.. ...
The ICU trauma resuscitation - Critical Concepts
Transfuse enough, but no more. The goal is a well-perfused patient. Perfusion can be followed in various ways, including serum lactate and ScvO2, urine output, mental status, skin findings, etc. Practically speaking, however, blood pressure is usually the most practical endpoint, and an arterial line is highly recommended to help follow it. Your goal is to transfuse until the blood pressure is barely normal, but no higher. Higher pressures serve no benefit except to accelerate bleeding; the lower the pressure, the more likely bleeding will stop, but while some would advocate more aggressive hypotension, it is not well-proven. Therefore, the familiar MAP goal of 65 is probably reasonable. When the MAP dips, give balanced blood; when you reach 65, stop. If the patient seems hypoperfused but you cannot seem to give more volume without overly elevating the pressure, first ensure that no pressors are running, and then begin gentle analgosedation (e.g. small boluses of fentanyl). While no sedation ...
Do not hyperventilate! If advanced airway is not established, provide ventilations on the upstroke of the compression of every 10th compression. Once advanced airway is in place, ventilate at a rate of 8-10 breaths per minute ...
Intrathecal Therapy for Chronic Non-Cancer Pain: An Analysis of Its Efficacy - Full Text View - ClinicalTrials.gov
Our hypothesis is that patients with intrathecal delivery systems for chronic non-cancer pain will report no improvement treatment efficacy when compared to patients with chronic pain managed with oral or systemic opioid therapies. Our secondary hypothesis is that patients with intrathecal delivery systems for chronic non-cancer pain will report no improvement in treatment efficacy when compared to patients with chronic pain who are managed with non-opioid therapies ...
Management of Chronic Non-Cancer Pain: A guide to appropriate use of Opioids
Myths and fears about addiction often prevent the use of opioids in treatment of chronic non-cancer pain. This article presents guidelines for safe and appropriate prescribing of opioids, monitoring of patients, and avoiding legal problems.
Respiratory Therapy Cave: Advanced Airway Lavage and Suction: The Latest Evidence
However, several years ago, the clinical practice guidelines for individuals with high tetraplegic SCIs were revised. It is no longer recommended to instill saline into an advanced airway because people with tetraplegia have little or no diaphragm innervation and, therefore, are unable to produce a cough reflex. This practice has been compared to drowning patients in their own secretions. After further review of the literature, we found saline instillation is not recommended for any adult patient who is mechanically ventilated. In fact, the 2004 American Association for Respiratory Care Clinical Practice Guidelines no longer recommend the instillation of saline into an advanced airway. (3) ...
Advanced Airway Larry Trainer Head | LF03684U made by Nasco | CPR Savers and First Aid Supply
Advanced Airway Larry Trainer Head-Life/form Advanced Airway Larry Airway Management Trainer offers tongue swelling and laryngospasm in addition to all the features on the standard models. Your students can now be presented with the additional challe
Advanced Airway Larry Trainer Head | LF03684U made by Nasco | CPR Savers and First Aid Supply
Advanced Airway Larry Trainer Head-Life/form Advanced Airway Larry Airway Management Trainer offers tongue swelling and laryngospasm in addition to al
Cardiac arrhythmias during or after epileptic seizures | Journal of Neurology, Neurosurgery & Psychiatry
We found a point prevalence of people with ictal asystole of 0.32%. In contrast, two small prospective studies (both n=19) with long-term implantable heart rhythm monitors up to 2 years reported a much higher prevalence of 5% and 21%.14 ,15 These contrasting figures suggest that ictal asystole does not occur during every seizure and may go unnoticed during short-term monitoring.. Ictal asystole, ictal bradycardia and ictal AV block coincided with a focal dyscognitive seizure and were predominantly seen in temporal lobe epilepsy. These three arrhythmias not only shared a similar clinical profile, but could also overlap. Both ictal bradycardia and ictal AV block may evolve into asystole.. It has been suggested that a seizure onset in the left hemisphere results in bradycardia and that a right-sided onset results in tachycardia.2 We did not, however, find a consistent lateralisation in the large group of ictal asystole and ictal bradycardia cases. In the small group of ictal AV block cases, there ...
Challenges to effective research in acute trauma resuscitation: Consent and endpoints<...
TY - JOUR. T1 - Challenges to effective research in acute trauma resuscitation. T2 - Consent and endpoints. AU - Holcomb, John B.. AU - Weiskopf, Richard. AU - Champion, Howard. AU - Gould, Steven A.. AU - Sauer, R. Michelle. AU - Brasel, Karen. AU - Bochicchio, Grant. AU - Bulger, Eileen. AU - Cotton, Bryan A.. AU - Davis, Daniel. AU - Dutton, Richard. AU - Hauser, Carl J.. AU - Hess, John R.. AU - Hides, George A.. AU - Knudson, Paula. AU - MacKenzie, Ellen. AU - McGinnis, Robert L.. AU - Michalek, Joel. AU - Moore, Frederick A.. AU - Omert, Laurel. AU - Pollock, Bradley H. AU - Tortella, Bartholomew. AU - Sugarman, Jeremy. AU - Schreiber, Martin A.. AU - Wade, Charles E.. PY - 2011/2. Y1 - 2011/2. N2 - Selection of study endpoints is one of the most important decisions in the design of effective clinical trials. Late mortality (e.g., 28 days) is an unambiguous endpoint, accepted by regulatory agencies, but it is viewed as problematic among researchers in the study of resuscitation for acute ...
Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort...
Irish drugs and alcohol research, data, policy and sources of evidence on prevention, treatment, rehabilitation, crime and consequences.
Intubation With A Curved Blade, direct laryngoscopy technique
This article discusses direct laryngoscopy intubation technique with a curved blade, including blade placement, errors & when a curved blade is preferred.
1991 - The absence of shallow breathing was the best predictor of successful weaning from mechanical ventilation |...
The value of an index for weaning from mechanical ventilation is its ability to predict respiratory endurance (1). Endurance reflects the ability of the respiratory capacity to meet the respiratory demands of resistive load from airways or endotracheal tube resistance, and elastic load from conditions that decrease compliance (e.g., fibrosis). Of the new indices that the authors present, the average VT and the ratio of respiratory frequency to tidal volume (f/VT) determined during a 1-minute bedside trial of spontaneous ventilation, are simple and warrant widespread consideration. 24 hours is a reasonable period of time to define successful liberation from mechanical ventilation but failures that occur shortly thereafter, often in less closely monitored environments, can have serious consequences. The f/VT index was the best predictor of successful weaning in this study. The usefulness of f/VT, however, should not eliminate careful systematic attention to other measurements that correlate ...
SU Awarded Contract To Direct Large Clinical Study In Trauma Resuscitation
Ground-breaking clinical research that has the potential to change pre-hospital care of civilian and military trauma victims worldwide
A multi‑center retrospective analysis of the effect of DPP4 inhibitors on progression‑free survival in advanced airway and...
The precise role of CD26/DPP4 in tumor biology is unclear at this time. Preclinical studies have shown conflicting data with differential CD26/DPP4 expression and activity depending on the type of cancer. These studies suggest that it has a role as either a tumor suppressor or tumor activator depending on the tumor microenvironment and molecules with which CD26/DPP4 associates (1,3). However, since most of these studies involved in vitro assays, further investigations with in vivo experiments are needed to definitively establish the role of CD26/DPP4 in each cancer type.. Published studies have demonstrated that CD26/DPP4 plays a major role in the invasion and metastasis of selected cancers, and may be a novel therapeutic target (1,2,5,6). There are several suggested mechanisms for cancer metastasis involving the intrinsic peptidase activity of CD26/DPP4 and its subsequent chemokine regulation, as well as its ability to bind key molecules. For example, CD26/DPP4 can upregulate the expression of ...
SHERIDAN NAZ-AL™ Endotracheal Tubes
SHERIDAN NAZ-AL™ Endotracheal Tubes,Nasal soft cuffed endotracheal tubes designed and constructed especially for long-term nasal intubations.,medicine,medical supply,medical supplies,medical product
Crash Kelly is a durable, rugged training manikin with an intubation head for advanced airway management training and realistic articulation allowing the manikin to be placed in various settings for extrication or rescue ...
Browsing Faculty of Medicine by Title
Background: Advanced airway management is a critical intervention that can harm the patient if performed poorly. The available literature on this subject is rich, but it is difficult to interpret due to a huge variability ...
Review, Urology Department of Novosibirsk State Medical University (Novosibirsk)
OPINION FROM THE UROLOGY DEPARTMENT OF NOVOSIBIRSK STATE MEDICAL UNIVERSITYin relation to performance of the Urolit nanopulse lithotripterNovosibirsk In October, 2010 - February, 2011 the Urology Department of Novosibirsk State Medical University (NSMU) performed contact lithotripsy procedures using the Urolit nanopulse lithotripter, manufactured by MedLine, Ltd. (Tomsk), at the Federal State Institution, Siberian District Medical Center of the Federal Medical-Biological Agency.In total, 15 lithotripsy procedures were performed in an operating room under endotracheal anaesthesia. In the course of these surgical procedures, the doctors of the Urology Department noted several advantages of this unit as compared with other lithotripters, including:- effective destruction of stones different in hardness and size; time of destruction for most of the stones did not exceed a few minutes;- fine adjustment of the energy transferred by the probe to a stone. Since maximum energy in a pulse does not exceed 0.8 J,
Identifying communicative factors affecting opioid management for chronic pain - Regenstrief Institute
The use of opioid medications for the treatment of chronic non-cancer pain has risen dramatically in the past two decades. There are a number of risks associated with the long term use of opioids, most notably the potential for misuse. Successful opioid management strategies for chronic non-cancer pain depend upon effective patient-provider communication. Improving the communication between providers and patients about opioids has tremendous potential to improve opioid management and reduce opioid misuse.. The purpose of this pilot study is to evaluate how patients with chronic non-cancer pain and their physicians communicate about opioid management. The data from this pilot study will be used to guide further research on the mechanisms behind communication about opioid management and the design of an intervention to improve physician communication with patients with chronic non-cancer pain about opioid treatment. ...
Sex Differences in Overlapping Chronic Non-cancer Pain Conditions in a Tertiary Pain Clinic | OMICS International
Sex differences have been reported repeatedly in pain and response to opioid analgesia with women representing the majority of chronic non-cancer pain (CNCP) patients as ..
NPS Webinar: Supporting patients living with chronic non-cancer pain - the role of the pharmacist
NPS Webinar: Join our panel of chronic pain experts as they discuss evidence-based approaches for managing chronic non-cancer pain and the role of pharmacists in reducing opioid-related harms.
Captopril improves neurologic outcome from incomplete cerebral ischemia in rats. | Stroke
We investigated the effects of the angiotensin-converting enzyme inhibitor captopril on neurologic outcome in a rat model of incomplete cerebral ischemia. Twenty male Sprague-Dawley rats were anesthetized with 70% nitrous oxide in oxygen and fentanyl (10 micrograms x kg-1 i.v. bolus, 25 micrograms x kg-1 x hr-1 i.v. continuous infusion). Animals in group 1 (n = 10) received no angiotensin-converting enzyme inhibitor while animals in group 2 (n = 10) were given 10 mg x kg-1 i.v. captopril 30 minutes prior to the ischemic period. Ischemia was produced by unilateral carotid artery ligation and hemorrhagic hypotension to 35 mm Hg for 30 minutes. Body temperature, arterial blood gases, and arterial pH were maintained constant. Neurologic outcome was evaluated every 24 hours for 3 days using a graded deficit score (0, normal; 18, stroke-related death). On the third day after ischemia, captopril significantly improved neurologic outcome (median deficit score = 4) compared with controls (median deficit ...
Staff Nurse RGN Registered General Nurse A&E - Trauma & Resuscitation Connacht Region Republic of Ireland | Jobs4Medical
Apply for Staff Nurse RGN Registered General Nurse A&E - Trauma & Resuscitation Connacht Region Republic of Ireland today. Upload your CV for regular medical job vacancy email alerts
The Pain and Opioids IN Treatment study: characteristics of a cohort using opioids to manage chronic non-cancer pain. - PubMed...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Xylitol Improves Bone Strength in Rats | Osteoporosis-Studies
Our previous studies have shown that dietary xylitol protects against weakening of bone biomechanical properties in experimental postmenopausal osteoporosis. To study whether xylitol preserves bone biomechanics also during aging, a long-term experimental study was performed with rats. Twenty-four male Sprague-Dawley rats were divided into 2 groups. The rats in the control group (NON-XYL group) were fed a basal rat and mouse no. 1 maintenance (RM1) diet, while the rats in the experimental group (XYL group) were continuously fed the same diet supplemented with 10% xylitol (wt/wt). The rats were killed after 20 months. Their femurs were prepared for biomechanical analyses and scanning analyses with peripheral quantitative computed tomography (pQCT). In 3-point bending of the femoral diaphysis, maximum load, maximum elastic load, stiffness, energy absorption, elastic energy absorption, ultimate stress, and yield stress were significantly greater in the XYL group than in the NON-XYL group. This ...
Nasotracheal tube definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
Advanced Airway Management With Cadavers November 2020 | American College of Chest Physicians
Advance your knowledge and expertise in difficult airway situations by practicing basic and advanced ICU intubation skills on cadavers in a low-risk environment. Attend this state-of-the-art, hands-on experience offering the preparation, teamwork, and tools necessary to manage complex airway situations.
Trauma | SpringerLink
Trauma is a leading cause of pediatric morbidity and mortality. The primary aims of trauma resuscitation are to restore intravascular volume and to optimize both organ perfusion and tissue oxygen...
Patient Succumbs to a Preventable Anesthesia Respiratory Event | MagMutual
Adverse outcomes associated with respiratory events continue to constitute the single largest class of injury in Closed Claims Study... read more.
Reflex circulatory responses to direct laryngoscopy and tracheal intubation performed during general anesthesia
RTECS:TD0350000 - Phosphoric acid, tri-o-tolyl ester - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH
intratracheal/chicken lowest published toxic dose: 750 mg/kg. Spinal Cord: Other degenerative changes. Peripheral Nerve and ... Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage). TAEHC* 110IV,122,1990. ... Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage). Nutritional and Gross ... Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage). Peripheral Nerve and ...
Murphy Endotracheal Tube - Wood Library-Museum of Anesthesiology
Subject: Intubation, Intratracheal - instrumentation.. Subject: Anesthesia, Intratracheal.. Subject: Airway Management ... Two improved intratracheal catheters. Anesth Analges.. 1941;20(2):102-105.. Note Type: Citation. Notes: Tamakawa S. Every ... position of Chief of Anesthesia at Harper Hospital. He was there until 1942,. when he enlisted in the United States Navy to ... Francis J. Murphy (1900-1972) was an outspoken proponent of the need for continuous oxygen supply during anesthesia. In 1941, ...
Artificial Stem Cells Mediated Inflammation-Tropic Delivery of Antiviral Drugs for Pneumonia Treatment | Research Square
Comparative Efficacy of 6 Topical Pharmacological Agents for... : Anesthesia & Analgesia
We used the following search terms: "intubation, intratracheal" OR "endotracheal intubation" "pharyngitis" OR "pharyngit*" OR ... 3. Macario A, Weinger M, Truong P, Lee M. Which clinical anesthesia outcomes are both common and important to avoid? The ... We thank the nursing and physician staff in the Nursing and Anesthesia Departments of the Cancer Hospital of China Medical ... Neuraxial Anesthesia and the Ubiquitous Platelet Count Question-How Low Is Too Low? ...
Eric L. Weiss, MD, DTM&H | Stanford Medicine
Eighteen critical care transport (CCT) nurses, previously unfamiliar with FOB, were asked to identify intratracheal and ... randomized study examining surgical patients undergoing general endotracheal anesthesia. Eighteen critical care transport (CCT ... Eighteen critical care transport (CCT) nurses, previously unfamiliar with FOB, were asked to identify intratracheal and ... nurses, previously unfamiliar with FOB, were asked to identify intratracheal and intraesophageal ETTs by using misting, end- ...
NIOSHTIC-2 Search Results - Full View
IMSEAR at SEARO: The Thai Anesthesia Incident Monitoring Study (Thai AIMS) of post anesthetic reintubation: an analysis of 184...
Intubation, Intratracheal. en_US. dc.subject.mesh. Male. en_US. dc.subject.mesh. Middle Aged. en_US. ... CONCLUSION: Extubation failure and reintubation was mostly related to anesthesia. Most of directly related to anesthesia group ... were classified as directly related to anesthesia and 55 cases (29.9%) were indirectly related to anesthesia. Oxygen ... The Thai Anesthesia Incident Monitoring Study (Thai AIMS) of post anesthetic reintubation: an analysis of 184 incident reports. ...
DeCS 2016 - Changed terms
DeCS 2016 - Changed terms
DeCS 2016 - Changed terms
DeCS 2016 - Changed terms
DeCS 2016 - Changed terms
DeCS 2016 - Changed terms
IMSEAR at SEARO: Search
Use of the bougie in simulated difficult intubation. 2. Comparison of single-use bougie with multiple-use bougie. - Oxford...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
All the patients in the two groups received intratracheal intubation with light-guide laryngoscopy under general anesthesia ... METHODS: Sixty cases at peri-intratracheal intubation period under general anesthesia were randomly divided into ... Effect of electroacupuncture on hemodynamics at peri-intratracheal intubation period under general anesthesia]. ... To observe effect of electroacupuncture on hemodynamics at peri-intratracheal intubation period under general anesthesia. ...
David Oman Warner - Research output - Mayo Clinic
Hooten, W. M., Townsend, C. O., Bruce, B. K. & Warner, D. O., Jan 2009, In: Anesthesia and analgesia. 108, 1, p. 308-315 8 p.. ... Duncan, C. M., Long, K. H., Warner, D. O. & Hebl, J. R., Jul 2009, In: Regional Anesthesia and Pain Medicine. 34, 4, p. 301-307 ... Fugate, J. E., Burns, J. D., Wijdicks, E. F. M., Warner, D. O., Jankowski, C. J. & Rabinstein, A. A., Dec 2010, In: Anesthesia ... Shi, Y. & Warner, D. O., Dec 2011, In: Anesthesia and analgesia. 113, 6, p. 1348-1351 4 p.. Research output: Contribution to ...
CRNA in waco, TX for Baylor Scott & White Health
... have been complied with prior to induction of anesthesia. Induces and maintains general anesthesia at required and safe levels ... Performs intratracheal intubation and extubation protecting the patient at all times. Identifies and manages emergency ... Functions as part of a health care/anesthesia team.. Ability to work variable hours.. Ability to share "on call" duties and be ... Terminates anesthesia in a timely fashion, ensuring patient safety to post-anesthetic recovery room. Reverses anesthetic ...
Department of Anesthesiology - Research output - Taipei Medical University
Hsieh, M. H., Chen, T-L., Lin, Y. H., Chang, C-C., Lin, C-S. & Lee, Y-W., 2008, In: Journal of Clinical Anesthesia. 20, 8, p. ... Anesthesia for patients with tracheal bronchus. Lai, K. M., Hsieh, M. H., Lam, F., Chen, C. Y., Chen, T. L. & Chang, C. C., Dec ... Huang, C. L., Tsai, P. S., Wang, T. Y., Yan, L. P., Xu, H. Z. & Huang, C. J., Mar 2007, In: Anesthesia and Analgesia. 104, 3, p ...
EFFECTS OF OXYMORPHONE OR FENTANYL ON SYSTEMIC HEMODYNAMICS AND PLASMA CONCENTRATIONS OF HISTAMINE, CATECHOLAMINES, AND...
William McAlister - Research output - Research Profiles at Washington University School of Medicine
Study on biological distribution of polyhexamethylene guanidine (PHMG), a toxic household chemical, using radiolabeling and...
In addition, we investigated the biodistribution after 111In-PHMG was exposed to SD rats through intratracheal instillation to ... five rats were sacrificed under anesthesia and the organs (heart, lungs, liver, spleen, kidneys, stomach, small intestine, ... Biological distribution of 111In-PHMG expressed as %ID/g of tissue; (a) intratracheal instillation and (b) oral administration. ... Then, the results will be discussed by comparing other organ distribution results obtained by the intratracheal instillation ...
Attenuation of acute lung injury in a rat model by Semen Cassiae | BMC Complementary Medicine and Therapies | Full Text
Male Sprague-Dawley rat lungs were injured by intratracheal instillation of LPS. Rats were treated with Semen Cassiae or ... Louis, MO, USA) intratracheal instillation was performed to induce ALI as described previously . Before use, LPS was ... All procedures were performed under anesthesia. Animals were randomly divided into various groups: control, LPS + vehicle, LPS ... Male Sprague-Dawley rat lungs were injured by intratracheal instillation of LPS. Rats were treated with Semen Cassiae or ...
Medical Definitions - Animal Medical Center of Seattle - Shoreline & Seattle
Tubes can be placed through the nose into the stomach (nasogastric) in a mildly sedated patient or under anesthesia directly ... intratracheal oxygen supplementation, oxygen cages, and mechanical ventilation. ... Heavy sedation or general anesthesia is needed to perform these procedures. Cultures for infection, wound drains, and bandages ... Intubation is required for general anesthesia.. ADVANCED THERAPEUTIC MODALITIES: Mechanical Ventilation - Mechanical ...
Nancy B Greilich - Fingerprint - University of Texas Southwestern Medical Center
Satya Krishna Ramachandran, M.B.,B.S. | Harvard Catalyst Profiles | Harvard Catalyst
A fiberoptic orotracheal intubation successfully performed using a modified Guedel airway in a sedated emergency patient - A...
General anesthesia was induced with propofol 120 mg and rocuronium 50 mg. We inserted the oral airway into the oral cavity. ... Keywords: Airway management; Aneshthesi general; Deep sedation; Intratracheal; Intubation Airway assessment is undoubtedly one ... If we can prepare a good airway for fiberoptic intubation, it should be useful for safer anesthesia. Our modified Guedel airway ... After the induction of general anesthesia, it was impossible to insert the direct laryngoscope deep enough for vocal cord ...
- Subject: Intubation, Intratracheal - instrumentation. (woodlibrarymuseum.org)
- The authors extracted relevant data from the incident reports on reintubation after planned extubation after general anesthesia with endotracheal intubation from the Thai AIMS database during the study period January to June 2007. (who.int)
- The durations of intratracheal intubation and SIRS were also shortened in the MP group. (fujita-hu.ac.jp)
- They include traumatic investigations of the larynx and trachea, prolonged laryngeal intubation, multiple re-intubations, the use of intratracheal tubes which are of a larger diameter. (impex.life)
- For its anatomical location in the neck, its functional role in breathing in phonation and its importance in the process of endotracheal intubation, the morphological characterization of the larynx is of great importance in the field of morphology, speech therapy and clinical specialties such as otolaryngology and anesthesia. (unab.edu.co)
- The endotracheal intubation with the use of inhalation anesthesia is used very especially in the from of large size laboratory animals, because it is a secure and easy control mode. (lookformedical.com)
- Thought you might appreciate this item(s) I saw in Anesthesia & Analgesia. (lww.com)
- Effect of GOAL-Directed ANalgesia using ANI (Analgesia/Nociception Index) during general anesthesia on immediate postoperative pain and intraoperative hemodynamics in adult patients (GOALDAN study): a study protocol for randomized, controlled, multicenter trial. (umontreal.ca)
- Effect of Patient Position with Spinal Anesthesia on the Heart Rate, Arterial Blood Pressure and Arterial Blood Gas Change. (ekja.org)
- In additional studies, the biokinetics of ultrafine particles and soluble 192Ir was studied after administra- tion by either gavage or intratracheal instillation or intravenous injection. (cdc.gov)
- Moreover, we quantified biodistribution of the radiolabeled PHMG exposed through intratracheal instillation and oral administration routes, and the observed data were compared to each other to understand in vivo behavior of PHMG. (eeer.org)
- Male Sprague-Dawley rat lungs were injured by intratracheal instillation of LPS. (biomedcentral.com)
- Direct laryngoscopy under anesthesia is a diagnostic step of utmost importance for thorough planning of surgical treatment. (impex.life)
- 2. For continuation as an analgesic into the immediate postoperative period in adult patients under the direct supervision of an anesthesia practitioner in a postoperative anesthesia care unit or intensive care setting. (liu.edu)
- After the induction of general anesthesia, it was impossible to insert the direct laryngoscope deep enough for vocal cord visualization without damaging the teeth because of limited mouth opening. (anesth-pain-med.org)
- Although there was a concern about airway difficulties on physical examination, we decided to proceed with general anesthesia because there had been no airway issues in previous surgeries. (anesth-pain-med.org)
- After giving consent for general anesthesia, the patient entered the operating room. (anesth-pain-med.org)
- General anesthesia was induced after routine and invasive haemodynamic monitoring started. (peertechzpublications.com)
- PATIENTS: 26 patients scheduled for surgery and general anesthesia. (duke.edu)
- Age-related Difference of the Vagal Reflex and Baroreceptor Reflex under General Anesthesia with Enflurane. (ekja.org)
- As an analgesic agent for use during the induction and maintenance of general anesthesia for inpatient and outpatient procedures. (liu.edu)
- One group received an infusion of MP (10 mg/kg) 30 minutes prior to the induction of anesthesia (MP group) and the other received a placebo infusion (control group, C group). (fujita-hu.ac.jp)
- To date there is no universally accepted protocol for induction, maintenance and recovery from anesthesia. (lookformedical.com)
- Aim: The aim of this paper is a review of the main methods of induction of anesthesia in laboratory animals. (lookformedical.com)
- 24 hours after exposure and overnight fasting, anesthesia was induced with 3% isoflurane, followed by maintenance anesthesia with 2% isoflurane at a rate 2 L/min. (cdc.gov)
- Anesthesia was maintained with isoflurane in a mixture of oxygen and nitrous oxide (30:70). (peertechzpublications.com)
- Dr. Francis J. Murphy (1900-1972) was an outspoken proponent of the need for continuous oxygen supply during anesthesia. (woodlibrarymuseum.org)
- After preoxygenation with 100% for 5 minute (target endtidal oxygen >90%), rapid sequence anesthesia was induced with IV thiopentone 325 mg and IV suxamethonium 125 mg. (peertechzpublications.com)
- Hypoventilation (58.1%) was the commonest cause which led to reintubation directly related to anesthesia while upper airway obstruction (39.6%) was the commonest cause in the indirectly related anesthesia group. (who.int)
- Airway assessment is undoubtedly one of the most important tasks in anesthesia. (anesth-pain-med.org)
- endotracheal i. passage of a tube through the nose or mouth into the trachea for maintenance of the airway during anesthesia or for ventilatory support or for maintenance of an imperiled airway . (en-academic.com)
- In contrast, intratracheal inoculation is believed to increase the reliability and reproducibility of the course of infection in lung [ 16 ], but nasal shedding of virus sometimes is decreased in both titer and duration compared with direct intranasal inoculation of the same strain [ 17 ]. (biomedcentral.com)
- 3. As an analgesic component of monitored anesthesia care in adult patients. (liu.edu)
- In 1930 he moved to Detroit to take the position of Chief of Anesthesia at Harper Hospital. (woodlibrarymuseum.org)
- Hospital unit providing continuous monitoring of the patient following anesthesia. (jefferson.edu)
- Experimental infection of pigs via direct intranasal or intratracheal inoculation has been mainly used to study the infectious process of influenza A viruses of swine (IAVs-S). Nebulization is known to be an alternative method for inoculating pigs with IAVs-S, because larger quantities of virus potentially can be delivered throughout the respiratory tract. (biomedcentral.com)
- Typically direct intranasal and intratracheal inoculation methods have been used to establish experimental infections in pigs. (biomedcentral.com)
- In addition, regional anesthesia of the distribution area of the SPG sensory fibers for nasal and dental surgery can be provided by SPGB via a transnasal, transoral, or lateral infratemporal approach. (sphenopalatineganglionblocks.com)
- Outside of emergency situations, the pharmacological antagonist phentolamine has been developed to reverse the effects of the vasoconstrictor in dental local anesthesia preparations when the effects of the agonist medication are no longer required. (cdeworld.com)
- IMSEAR at SEARO: The Thai Anesthesia Incident Monitoring Study (Thai AIMS) of post anesthetic reintubation: an analysis of 184 incident reports. (who.int)
- Chinachoti T, Poopipatpab S, Buranatrevedhya S, Taratarnkoolwatana K, Werawataganon T, Jantorn P. The Thai Anesthesia Incident Monitoring Study (Thai AIMS) of post anesthetic reintubation: an analysis of 184 incident reports. (who.int)
- OBJECTIVE: The present study was a part of the Multi-centered Study of Model of Anesthesia related Adverse Events in Thailand by Incident Report (The Thai Anesthesia Incident Monitoring Study or Thai AIMS). (who.int)
- Eighteen critical care transport (CCT) nurses, previously unfamiliar with FOB, were asked to identify intratracheal and intraesophageal ETTs by using misting, end-tidal carbon dioxide concentration (ETCO(2)), and FOB alone or with a combination of all three modes. (stanford.edu)
- specifically, passage of an oro- or nasotracheal tube for anesthesia or for control of pulmonary ventilation . (en-academic.com)
- Title: Murphy intratracheal catheters. (woodlibrarymuseum.org)
- A Review of the Anesthesia Specialty Examination for Board Certification in 1998. (ekja.org)
- This step can be operated 1 days ahead without anesthesia. (genemedi.net)
- The Ventilatory Effect of Intratracheal Pulmonary Ventilation in Rabbits with Acute Respiratory Failure. (ekja.org)