Anemia hypoplastic congenital. Medical search

A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.

A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).

Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)

Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.

Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)

Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).

A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)

A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.

Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow.

A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS.

A species of LENTIVIRUS, subgenus equine lentiviruses (LENTIVIRUSES, EQUINE), causing acute and chronic infection in horses. It is transmitted mechanically by biting flies, mosquitoes, and midges, and iatrogenically through unsterilized equipment. Chronic infection often consists of acute episodes with remissions.

The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.

A severe sometimes chronic anemia, usually macrocytic in type, that does not respond to ordinary antianemic therapy.

Hemolytic anemia due to various intrinsic defects of the erythrocyte.

Viral disease of horses caused by the equine infectious anemia virus (EIAV; INFECTIOUS ANEMIA VIRUS, EQUINE). It is characterized by intermittent fever, weakness, and anemia. Chronic infection consists of acute episodes with remissions.

Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.

The type species of GYROVIRUS, a small, non-enveloped DNA virus originally isolated from contaminated vaccines in Japan. It causes chicken infectious anemia and may possibly play a key role in hemorrhagic anemia syndrome, anemia dermatitis, and blue wing disease.

A familial disorder characterized by ANEMIA with multinuclear ERYTHROBLASTS, karyorrhexis, asynchrony of nuclear and cytoplasmic maturation, and various nuclear abnormalities of bone marrow erythrocyte precursors (ERYTHROID PRECURSOR CELLS). Type II is the most common of the 3 types; it is often referred to as HEMPAS, based on the Hereditary Erythroblast Multinuclearity with Positive Acidified Serum test.

A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)

A diverse group of proteins whose genetic MUTATIONS have been associated with the chromosomal instability syndrome FANCONI ANEMIA. Many of these proteins play important roles in protecting CELLS against OXIDATIVE STRESS.

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.

The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.

The mildest form of erythroblastosis fetalis in which anemia is the chief manifestation.

Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.

Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.

A Fanconi anemia complementation group protein that regulates the activities of CYTOCHROME P450 REDUCTASE and GLUTATHIONE S-TRANSFERASE. It is found predominately in the CYTOPLASM, but moves to the CELL NUCLEUS in response to FANCE PROTEIN.

A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.

The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.

A Fanconi anemia complementation group protein that is the most commonly mutated protein in FANCONI ANEMIA. It undergoes PHOSPHORYLATION by PROTEIN KINASE B and forms a complex with FANCC PROTEIN in the CELL NUCLEUS.

The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.

Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte. Common causes include deficiencies in GLUCOSE-6-PHOSPHATE ISOMERASE; PYRUVATE KINASE; and GLUCOSE-6-PHOSPHATE DEHYDROGENASE.

A clinical manifestation consisting of an unnatural paleness of the skin.

The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.

Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.

ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).

Measurement of hemoglobin concentration in blood.

The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)

Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.

A Fanconi anemia complementation group protein that undergoes PHOSPHORYLATION by CDC2 PROTEIN KINASE during MITOSIS. It forms a complex with other FANCONI ANEMIA PROTEINS and helps protect CELLS from DNA DAMAGE by genotoxic agents.

A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.

The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.

Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.

Organic and inorganic compounds that contain iron as an integral part of the molecule.

Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.

Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.

The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.

The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.

A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)

The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.

A genus in the family ORTHOMYXOVIRIDAE containing one species: Infectious salmon anemia virus.

Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.

A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.

A Fanconi anemia complementation group protein. It is an essential component of a nuclear core complex that protects the GENOME against CHROMOSOMAL INSTABILITY. It interacts directly with FANCG PROTEIN and helps stabilize a complex with FANCA PROTEIN and FANCC PROTEIN.

Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)

A Fanconi anemia complementation group protein that interacts with FANCC PROTEIN and FANCD2 PROTEIN. It promotes the accumulation of FANCC protein in the CELL NUCLEUS.

The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.

A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.

Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.

Enlargement of the spleen.

Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.

RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.

Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.

Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.

The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Inorganic or organic compounds that contain divalent iron.

Proteins prepared by recombinant DNA technology.

An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)

The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.

Abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells. They are seen in thalassemias, enzymopathies, hemoglobinopathies, and after splenectomy.

Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.

Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.

A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.

A subnormal level of BLOOD PLATELETS.

An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.

Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.

A glycoprotein secreted by the cells of the GASTRIC GLANDS that is required for the absorption of VITAMIN B 12 (cyanocobalamin). Deficiency of intrinsic factor leads to VITAMIN B 12 DEFICIENCY and ANEMIA, PERNICIOUS.

A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.

A group of familial congenital hemolytic anemias characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.

The process by which fetal Rh+ erythrocytes enter the circulation of an Rh- mother, causing her to produce IMMUNOGLOBULIN G antibodies, which can cross the placenta and destroy the erythrocytes of Rh+ fetuses. Rh isoimmunization can also be caused by BLOOD TRANSFUSION with mismatched blood.

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.

The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.

A republic in eastern Africa, south of UGANDA and north of MOZAMBIQUE. Its capital is Dar es Salaam. It was formed in 1964 by a merger of the countries of TANGANYIKA and ZANZIBAR.

An infant during the first month after birth.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.

The co-occurrence of pregnancy and parasitic diseases. The parasitic infection may precede or follow FERTILIZATION.

Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.

The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children.

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

The persistent eating of nonnutritive substances for a period of at least one month. (DSM-IV)

State of the body in relation to the consumption and utilization of nutrients.

Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.

Virus infections caused by the PARVOVIRIDAE.

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

An imbalanced nutritional status resulted from insufficient intake of nutrients to meet normal physiological requirement.

Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Surgical procedure involving either partial or entire removal of the spleen.

A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.

Disorders of the blood and blood forming tissues.

An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.

An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE production. Reticulocytosis occurs during active BLOOD regeneration (stimulation of red bone marrow) and in certain types of ANEMIA, particularly CONGENITAL HEMOLYTIC ANEMIA.

Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.

A republic in eastern Africa, south of ETHIOPIA, west of SOMALIA with TANZANIA to its south, and coastline on the Indian Ocean. Its capital is Nairobi.

Tests used in the analysis of the hemic system.

The condition of being heterozygous for hemoglobin S.

A commercially important species of SALMON in the family SALMONIDAE, order SALMONIFORMES, which occurs in the North Atlantic.

Elements of limited time intervals, contributing to particular results or situations.

In utero transfusion of BLOOD into the FETUS for the treatment of FETAL DISEASES, such as fetal erythroblastosis (ERYTHROBLASTOSIS, FETAL).

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.

Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.

Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed)

A synthetic hormone with anabolic and androgenic properties. It is used mainly in the treatment of anemias. According to the Fourth Annual Report on Carcinogens (NTP 85-002), this compound may reasonably be anticipated to be a carcinogen. (From Merck Index, 11th ed)

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.

Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production.

A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups.

The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.

Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.

Pathological processes of the KIDNEY or its component tissues.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

Stable iron atoms that have the same atomic number as the element iron, but differ in atomic weight. Fe-54, 57, and 58 are stable iron isotopes.

Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.

Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)

Removal of bone marrow and evaluation of its histologic picture.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

A republic in western Africa, south of BURKINA FASO and west of TOGO. Its capital is Accra.

Neutrophil functions in patients with inherited bone marrow failure syndromes. (1/1)

(+info)

... is a type of aplastic anemia which is primarily due to a congenital disorder. Associated genes ... Examples include: Fanconi anemia Diamond-Blackfan anemia Online Mendelian Inheritance in Man (OMIM): 609135 v t e (Articles ... with short description, Short description is different from Wikidata, Aplastic anemias, All stub articles, Disease stubs, ...

https://en.wikipedia.org/wiki/Congenital_hypoplastic_anemia

Diamond LK, Allen DW, Magill FB (1961). "Congenital (erythroid) hypoplastic anemia: a 25 year study". Am. J. Dis. Child. 102 (3 ... GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia OMIM entries on Diamond-Blackfan Anemia Diamond-Blackfan anemia ... who described congenital hypoplastic anemia in 1938. Responsiveness to corticosteroids was reported in 1951. In 1961, Diamond ... Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia that usually presents in infancy. DBA causes low red blood cell ...

https://en.wikipedia.org/wiki/Diamond–Blackfan_anemia

December 2018). "Complexities of genetic diagnosis illustrated by an atypical case of congenital hypoplastic anemia". Cold ... Meanwhile, those with PRCA can display a similar disease to Diamond-Blackfan anemia. The onset of PRCA caused by DADA2 is ... Sasa G (2015). "Adenosine Deaminase 2 Deficiency As a Cause of Pure Red Cell Aplasia Mimicking Diamond Blackfan Anemia". Blood ... whereas mutations in the catalytic domain lead to the Diamond Blackfan anemia-like phenotype. In another study, specific ...

https://en.wikipedia.org/wiki/Adenosine_deaminase_2_deficiency

... lymphoma and congenital (erythroid) hypoplastic anemia. Pulmonary: aspiration pneumonitis, chronic beryllium disease, ... Endocrinology: congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis, and primary or ... Hematology: acquired (autoimmune) hemolytic anemia, idiopathic thrombocytopenic purpura, secondary thrombocytopenia, ...

https://en.wikipedia.org/wiki/Methylprednisolone

"Effect of subcutaneous deferoxamine and oral vitamin C on iron excretion in congenital hypoplastic anemia and refractory anemia ... Hereditary hemolytic anemias, Disorders of globin and globulin proteins). ... with β-thalassemia trait should be warned that their condition can be misdiagnosed for the common Iron deficiency anemia. They ...

https://en.wikipedia.org/wiki/Management_of_thalassemia

Anemia Anemia, Diamond-Blackfan Anemia, hypoplastic, congenital Anemia, pernicious Anemia, sideroblastic Anemia sideroblastic ... congenital Adrenal hypertension Adrenal hypoplasia Adrenal hypoplasia congenital, X-linked Adrenal incidentaloma Adrenal ... congenital Antisocial personality disorder Antisynthetase syndrome Antithrombin deficiency, congenital Antley-Bixler syndrome ... anemia due to Adenylosuccinate lyase deficiency Adie syndrome Adiposis dolorosa, aka Dercum's disease Adolescent benign focal ...

https://en.wikipedia.org/wiki/List_of_diseases_(A)

... anemia, aplastic MeSH C15.378.190.196.080 - anemia, hypoplastic, congenital MeSH C15.378.190.196.080.090 - anemia, diamond- ... MeSH C15.378.071.085 - anemia, aplastic MeSH C15.378.071.085.080 - anemia, hypoplastic, congenital MeSH C15.378.071.085.080.090 ... anemia, hemolytic, autoimmune MeSH C15.378.071.141.150 - anemia, hemolytic, congenital MeSH C15.378.071.141.150.095 - anemia, ... anemia, hemolytic, congenital nonspherocytic MeSH C15.378.071.141.150.150 - anemia, sickle cell MeSH C15.378.071.141.150.150. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C15)

... is a type of multiple congenital anomaly/intellectual disability (MCA/MR) syndrome. It is characterized by ... Symptoms include megalocephaly, external ear deformities, dental caries, micromelia, hypoplastic bone deformities, hypogonadism ... hypochromic anemia with occasional tumors, and intellectual disability. Firkin, Barry G.; Whitworth, Judith A. (2001). ... v t e (Articles with short description, Short description is different from Wikidata, Congenital disorders, Syndromes affecting ...

https://en.wikipedia.org/wiki/Benjamin_syndrome

CHARGE syndrome Cleft palate Coarctation of the aorta Congenital adrenal hyperplasia Congenital diaphragmatic hernia Congenital ... Diseases of concern during the neonatal period include: Anemia of prematurity Apnea of prematurity Atrial septal defect ... hemangiomatosis DiGeorge syndrome Encephalocele Gastroschisis Hemolytic disease of the newborn Hirschsprung disease Hypoplastic ... congenital malformations (birth defects), sepsis, pulmonary hypoplasia or birth asphyxia. Though high infant mortality rates ...

https://en.wikipedia.org/wiki/Neonatology

... hypoplastic). Ultimately, this leads to respiratory failure. Epilepsy (seizures) can occur and can prove lethal. Regions of ... perinatal hypophosphatasia can be distinguished from even the most severe forms of osteogenesis imperfecta and congenital ... developing, unmineralized bone (osteoid) may expand and encroach on the marrow space, resulting in myelophthisic anemia. In ... X-rays readily distinguish hypophosphatasia from osteogenesis imperfecta and congenital dwarfism. Some stillborn skeletons show ...

https://en.wikipedia.org/wiki/Hypophosphatasia

... such as Turner's hypoplasia Chambers of the heart in hypoplastic left heart syndrome and hypoplastic right heart syndrome Optic ... It is technically not the opposite of hyperplasia (too many cells). Hypoplasia is a congenital condition, while hyperplasia ... Breasts during puberty Testes in Klinefelter's syndrome Ovaries in Fanconi anemia, gonadal dysgenesis, trisomy X Thymus in ... Hypoplasia (from Ancient Greek ὑπo- hypo- 'under' + πλάσις plasis 'formation'; adjective form hypoplastic) is underdevelopment ...

https://en.wikipedia.org/wiki/Hypoplasia

Congenital disorders of endocrine system, Congenital disorders of nervous system, Pituitary disorders, Syndromes affecting the ... and Fanconi anaemia. PSIS may be isolated, or, commonly, present with extra-pituitary malformations. PSIS features in neonates ... an ectopic or absent posterior pituitary and/or absent or hypoplastic anterior pituitary. Affected individuals may present with ... Pituitary stalk interruption syndrome (PSIS) is a congenital disorder characterised by the triad of an absent or exceedingly ...

https://en.wikipedia.org/wiki/Pituitary_stalk_interruption_syndrome

Type VII of radial polydactyly is associated with several syndromes: Holt-Oram syndrome, Fanconi anemia (aplastic anemia by the ... Flatt AE (1977). The care of congenital hand anomalies. St. Louis: Mosby. McCarroll, H.Relton (November 2000). "Congenital ... The little finger can be hypoplastic or fully developed. Type B varies from a nubbin to an extra, non-functional little finger ... children with a congenital upper extremity deformity should be examined by a geneticist for other congenital anomalies. This ...

https://en.wikipedia.org/wiki/Polydactyly

Congenital disorders, Congenital disorders of musculoskeletal system, Rare diseases, Fingers). ... Children with Fanconi anemia can sometimes display hypoplasia of the thumb.[citation needed] Three main points in diagnosing ... Children with type III are the most difficult patients to treat because there is not one specific treatment for the hypoplastic ... Thumb hypoplasia is a spectrum of congenital abnormalities of the thumb varying from small defects to complete absence of the ...

https://en.wikipedia.org/wiki/Thumb_hypoplasia

AR Anemia, congenital dyserythropoietic, type I; 224120; CDAN1 Anemia, dyserythropoietic congenital, type II; 224100; SEC23B ... hypomaturation-hypoplastic type, with taurodontism; 104510; DLX3 Amelogenesis imperfecta, hypoplastic/hypomaturation type; ... SCN5A Heinz body anemia; 140700; HBA2 Heinz body anemias, alpha-; 140700; HBA1 Heinz body anemias, beta-; 140700; HBB HELLP ... RPL5 Diamond-Blackfan anemia 7; 612562; RPL11 Diamond-Blackfan anemia 8; 612563; RPS7 Diamond-Blackfan anemia 9; 613308; RPS10 ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

15 to 33 percent of patients with TO fistulas will also have congenital heart disease. However these babies usually have ... Vertebral anomalies, or defects of the spinal column, usually consist of small (hypoplastic) vertebrae or hemivertebra where ... Baller-Gerold syndrome CHARGE syndrome Currarino syndrome DiGeorge syndrome Fanconi anemia Feingold syndrome Fryns syndrome ... Limb defects occur in up to 70 percent of babies with VACTERL association and include a displaced or hypoplastic thumb, extra ...

https://en.wikipedia.org/wiki/VACTERL_association

... pigmentosa diabetes mellitus Muscular dystrophy congenital infantile cataract hypogonadism Muscular dystrophy congenital, ... meningococcal Meningitis Meningocele Meningococcemia Meningoencephalocele Meningoencephalocele-arthrogryposis-hypoplastic thumb ... ophthalmoplegia hypoacousia areflexia Myopathy tubular aggregates Myopathy with lactic acidosis and sideroblastic anemia ... congenital Mirhosseini-Holmes-Walton syndrome Mirror hands feet nasal defects Mirror polydactyly segmentation and limbs defects ...

https://en.wikipedia.org/wiki/List_of_diseases_(M)

Syndrome is associated with this syndrome usually presenting as a Hypoplastic Bone Marrow that can resemble Aplastic Anemia, ... Dyskeratosis congenita (DKC), also known as Zinsser-Engman-Cole syndrome, is a rare progressive congenital disorder with a ... anemia, testicular atrophy in the male carriers, and predisposition to cancer. Many of these symptoms are characteristic of ... Congenital disorders, Rare diseases, DNA replication and repair-deficiency disorders, Telomeres, Progeroid syndromes). ...

https://en.wikipedia.org/wiki/Dyskeratosis_congenita

Manske PR, Goldfarb CA (2009). "Congenital failure of formation of the upper limb". Hand Clin. 25 (2): 157-70. doi:10.1016/j. ... Hypoplastic radius in miniature Type III: Absent distal radius Type IV: Complete absent radius Type V: Complete absent radius ... the gastrointestinal VATER syndrome and the hematologic Fanconi anemia and TAR syndrome. Other possible causes are an injury to ... Radial dysplasia, also known as radial club hand or radial longitudinal deficiency, is a congenital difference occurring in a ...

https://en.wikipedia.org/wiki/Radial_dysplasia

Urobilinogen will be greater than 2 units, as hemolytic anemia causes increased heme metabolism; one exception being the case ... congenital hypothyroidism) Sepsis or other infectious causes Transient neonatal jaundice is one of the most common conditions ... genetic defect resulting in hypoplastic intrahepatic bile ducts) Progressive familial intrahepatic cholestasis Pyknocytosis ( ... These diseases may cause jaundice due to increased erythrocyte hemolysis: Sickle-cell anemia Spherocytosis Thalassemia Pyruvate ...

https://en.wikipedia.org/wiki/Jaundice

Congenital erythropoietic porphyria (Gunther disease) is a rare congenital form of porphyria, and may be associated with red or ... More severe cases show severely hypoplastic patches of enamel, which are also prone to accumulation of surface stains. ... One such condition is hemolytic disease of the newborn (erythroblastosis fetalis). Thalassemia and sickle cell anemia may be ...

https://en.wikipedia.org/wiki/Tooth_discoloration

Hypoplastic left heart syndrome Hypoplastic right heart microcephaly Hypoplastic thumb mullerian aplasia Hypoplastic thumbs ... congenital Hillig syndrome Hing-Torack-Dowston syndrome Hinson-Pepys disease Hip dislocation Hip dysplasia Beukes type Hip ... Hereditary t Hereditary nodular heterotopia Hereditary non-spherocytic hemolytic anemia Hereditary pancreatitis Hereditary ... congenital essential Hemeralopia, familial Hemi 3 syndrome Hemifacial atrophy agenesis of the caudate nucleus Hemifacial ...

https://en.wikipedia.org/wiki/List_of_diseases_(H)

... (TPT) is a congenital malformation where the thumb has three phalanges instead of two. The extra phalangeal ... Syndromes include: Holt-Oram syndrome Aase syndrome Diamond-Blackfan anemia Townes-Brocks syndrome Malformations include: ... the surgical treatment typically consists of removing the additional mostly hypoplastic thumb(s). Further procedures of ... Wood, treatment of the triphalangeal thumb, Clin Orthop, 1976 Buck-Gramcko, congenital and development conditions, the ...

https://en.wikipedia.org/wiki/Triphalangeal_thumb

CDC (2019-11-19). "Congenital Heart Defects - Facts about Hypoplastic Left Heart Syndrome". Centers for Disease Control and ... Younger age - Pregnant teenagers are more likely to develop anemia, have preterm births, and have low birth weight babies. ... Congenital defects: The management of congenital defects in the fetus depends on the specific condition. For example, certain ... for congenital syphilis) or antifungals. Another option for prevention of transmission includes delivery via Caesarian delivery ...

https://en.wikipedia.org/wiki/High-risk_pregnancy

Hypoplastic left heart syndrome - Defect in the development of the left heart such that it is hypoplastic (under developed). ... Uhl anomaly - A congenital heart defect in which the right ventricular myocardium is too thin or absent. It is a very rare ... The main cause of angina is coronary artery disease, but can result from other non-atherosclerotic causes such as anemia and ... Ebstein's anomaly - A congenital heart defect that results in the tricuspid valve leaflets being deeper in the heart (toward ...

https://en.wikipedia.org/wiki/Outline_of_cardiology

... congenital MeSH C16.320.070.100 - anemia, hemolytic, congenital nonspherocytic MeSH C16.320.070.150 - anemia, sickle cell MeSH ... hypoplastic left heart syndrome MeSH C16.131.240.400.685 - Leopard syndrome MeSH C16.131.240.400.701 - levocardia MeSH C16.131. ... anemia, Diamond-Blackfan MeSH C16.320.077.280 - fanconi anemia MeSH C16.320.099.037 - activated protein C resistance MeSH ... congenital MeSH C16.131.621.551 - Klippel-Feil syndrome MeSH C16.131.621.585 - limb deformities, congenital MeSH C16.131. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C16)

These are known as cyanotic congenital heart defects and are often more serious. Major congenital heart defects are often ... These often include a full blood count investigating for anaemia, and basic metabolic panel that may reveal any disturbances in ... hypoplastic left heart syndrome). Common abnormalities include those that affect the heart muscle that separates the two side ... More minor forms of congenital heart disease may remain undetected for many years and only reveal themselves in adult life (e.g ...

https://en.wikipedia.org/wiki/Heart

... lipodystrophy Congenital insensitivity to pain Congenital myasthenic syndrome Congenital nephrotic syndrome Congenital rubella ... Hyperventilation syndrome Hyperviscosity syndrome Hypohidrotic ectodermal dysplasia Hypoplastic left heart syndrome Hypoplastic ... lysis syndrome Tumor necrosis factor receptor associated periodic syndrome Turner syndrome Twiddler's syndrome Twin Anemia- ... syndrome Complex regional pain syndrome Computer vision syndrome Congenital bilateral perisylvian syndrome Congenital ...

https://en.wikipedia.org/wiki/List_of_syndromes

... anemia, prematurity, low birth weight, renal failure, heavy metal intoxication or tobacco smoke, among others. Regional ... suggesting that the a3 gene mutation found in V-ATPases also plays a role in the development of hypomineralized and hypoplastic ... congenital syphilis), hypocalcemia, fluoride ingestion, birth injury, preterm birth, infection or trauma from a deciduous tooth ...

https://en.wikipedia.org/wiki/Human_tooth_development

... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q ...

https://apps.who.int:80/iris/handle/10665/25/browse?authority=Anemia%2C+Hypoplastic%2C+Congenital&type=mesh

Browsing by Subject "Anemia, Hypoplastic, Congenital". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W ...

https://extranet.who.int/iris/restricted/browse?authority=Anemia%2C+Hypoplastic%2C+Congenital&type=mesh

CHA congenital hypoplastic anemia. CHB complete heart block. CHD congestive heart disease; coronary heart disease; congenital ... PA pernicious anemia; paralysis agitans; pulmonary artery; peripheral arteriosclerosis. PAC premature auricular contraction; ...

https://www.cdc.gov/nchs/nvss/manuals/2020/2a-appendix-2020.htm

Diamond-Blackfan anemia is a disorder that primarily affects the bone marrow. Explore symptoms, inheritance, genetics of this ... Chronic congenital agenerative anemia. *Congenital erythroid hypoplastic anemia. *Congenital hypoplastic anemia of Blackfan and ... The resulting shortage of red blood cells (anemia. ) usually becomes apparent during the first year of life. Symptoms of anemia ... Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome. Adv Biol ...

https://medlineplus.gov/genetics/condition/diamond-blackfan-anemia/

Acquired (autoimmune) hemolytic anemia. Erythroblastopenia (RBC anemia). Congenital (erythroid) hypoplastic anemia. 9. ... Congenital adrenal hyperplasia. Hypercalcemia associated with cancer. Nonsuppurative thyroiditis. 2. Rheumatic Disorders As ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84c6be5c-df0d-41b4-9b0d-641fba970ac2

Congenital hypoplastic anemia. 4 / 7739 89. (HPO:0010701) Abnormal immunoglobulin level. Occasional [Orphanet] 49 / 7739 ... In all but 1 patient, anemia developed before 5 months of age; the remaining patient developed aplastic anemia at 2.5 years of ... The reticulocyte index was always low in relation to the anemia. Anemia, which was most prevalent and severe during infancy, ... Most patients had normocytic anemia, but 2 had macrocytic anemia. Five patients had thrombocytosis. Follow-up of the living ...

http://mips.helmholtz-muenchen.de/phenodis/disease/show/1355

For the treatment of acquired (autoimmune) hemolytic anemia, erythroblastopenia (RBC anemia), or congenital hypoplastic anemia ... anemia / Delayed / Incidence not known. glossitis / Early / Incidence not known. hepatomegaly / Delayed / Incidence not known. ... For primary (Addisons disease) or secondary adrenocortical insufficiency or for the treatment of congenital adrenal ... Micafungin: (Moderate) Leukopenia, neutropenia, anemia, and thrombocytopenia have been associated with micafungin. Patients who ...

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... hemolytic anemia; erythroblastopenia (RBC anemia); congenital (erythroid) hypoplastic anemia. Neoplastic DiseasesFor palliative ... congenital adrenal hyperplasia; hypercalcemia associated with cancer; nonsuppurative thyroiditis. Rheumatic DisordersAs ...

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Ravilla R, Joiner AK, Alapat D, Arnaoutakis K. An Unusual Case of Acute Promyelocytic Leukemia Presenting With Hypoplastic Bone ... A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. ... Cai B, Said Q, Li X, Li FY, Arcona S. Healthcare resource use and direct costs in severe aplastic anemia (SAA) patients before ... Cai B, Said Q, Li X, Li FY, Arcona S. Healthcare costs and resource utilization in patients with severe aplastic anemia in the ...

https://uams-triprofiles.uams.edu/profiles/display/99522

Congenital Hypoplastic Anemia Congenital Hypoplastic Anemias Hypoplastic Anemia, Congenital Hypoplastic Anemias, Congenital ... Anemia, Congenital Hypoplastic. Anemias, Congenital Hypoplastic. Congenital Hypoplastic Anemia. Congenital Hypoplastic Anemias ... Anemia, Hypoplastic, Congenital Entry term(s). Anemia, Congenital Hypoplastic Anemias, Congenital Hypoplastic ... Hypoplastic Anemia, Congenital. Hypoplastic Anemias, Congenital. Tree number(s):. C15.378.071.085.080. C15.378.190.223.500.500 ...

https://decs.bvsalud.org/en/ths/resource/?id=36022

Congenital hypoplastic anemia (disorder). Code System Preferred Concept Name. Congenital hypoplastic anemia (disorder). ... Chronic constitutional pure red cell anaemia Active Synonym false false 508247011 Familial hypoplastic anaemia Active Synonym ... Diamond-Blackfan anemia Active Synonym false false 147326019 Chronic constitutional pure red cell anemia Active Synonym false ... Congenital hypoplastic anemia Active Synonym false false 147329014 Familial hypoplastic anemia Active Synonym false false ...

https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=88854002

Congenital Hypoplastic Anaemia. Issue Date: Oct-2011. Citation: Singh Sunita, Singh Sukhbir, Singh Pawan, Marwah Nisha, Singh ... Bone marrows of hospitalized children with anaemia were examined to study the incidence and profile of erythroblastopenia in ... The disease was found to be associated with PEM and nutritional anaemia (55%), gastroenteritis (12.5%) and respiratory tract ... Forty children aged between 7 months to 12 years with anaemia, reticulocytopenia and isolated erythroblastopenia on Bone marrow ...

https://imsear.searo.who.int/handle/123456789/172099

Acquired aplastic anemia, congenital anemia, myelofibrosis, and hypoplastic anemias. Recreational anabolic-androgenic steroid ... Anadrol-50 (oxymetholone) is an anabolic steroid used to treat certain types of anemia (lack of red blood cells), including ... Anadrol-50 (oxymetholone) is an anabolic steroid used to treat certain types of anemia (lack of red blood cells), including ... Androl-50 (oxymetholone) (anabolic steroids-oral). Anemia caused by deficient red cell production. ...

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congenital hypoplastic anemia. DOID:1342. 0. 0.014. immune system disease. DOID:2914. 0. 0.014. ...

http://imp.princeton.edu/predictions/gene/yeast-context-global/25678/

Congenital (erythroid) hypoplastic anemia. *Neoplastic Diseases For palliative management of: * Leukemias and lymphomas in ... Congenital Adrenal Hyperplasia,Hemolytic Anemia,Hypercalcemia,Dermatitis,Dermatitis Herpetiformis,Dermatitis,Atopic,Dermatitis, ... Acquired (autoimmune) hemolytic anemia. * Idiopathic thrombocytopenic purpura in adults (IV only; IM administration is ... Addisons Disease,Allergic Conjunctivitis,Anemia,Ankylosing Spondylitis,Arthritis,Osteoarthritis,Asthma,Atopic Dermatitis, ...

https://pillintrip.com/medicine/a-methapred

Erythroblastopenia (RBC anemia). Congenital (erythroid) hypoplastic anemia. 9. Neoplastic Diseases For palliative management of ... Congenital adrenal hyperplasia Nonsuppurative thyroiditis Hypercalcemia associated with cancer. 2. Rheumatic Disorders As ... Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia. ...

https://medlibrary.org/lib/rx/meds/cortisone-acetate-6/

Acquired (autoimmune) hemolytic anemia. Erythroblastopenia (RBC anemia). Congenital (erythroid) hypoplastic anemia. 9. ... Congenital adrenal hyperplasia. Nonsuppurative thyroiditis. 2. Rheumatic Disorders. As adjunctive therapy for short-term ...

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Anemia, Hypoplastic, Congenital. Genetic Diseases, Inborn. DNA Repair-Deficiency Disorders. Metabolic Diseases. Renal Tubular ... Genetic and Rare Diseases Information Center resources: Aplastic Anemia Fanconi Anemia Congenital Aplastic Anemia Fanconi ... Anemia. Anemia, Aplastic. Fanconi Anemia. Bone Marrow Failure Disorders. Pancytopenia. Hemoglobinuria, Paroxysmal. Anemia, ... Anemia, Hemolytic. Myelodysplastic Syndromes. Red-Cell Aplasia, Pure. Skin Abnormalities. Congenital Abnormalities. Genetic ...

https://clinicaltrials.gov/ct2/show/NCT00027274

Parvovirus infections and hypoplastic crisis in sickle-cell anaemia (Letter). Lancet 1981;1:664-5. * Knott PD, Welply GAC, ... Patients with Congenital and Acquired Immunodeficiencies The exposed patient with a congenital or acquired immunodeficiency ... Patients at risk for TAC include those with chronic hemolytic anemias and those with anemias associated with acute or chronic ... Patients with Chronic Hemolytic Anemia The exposed patient with chronic hemolytic anemia should be managed by alerting the ...

https://wonder.cdc.gov/wonder/prevguid/m0001348/m0001348.asp

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Sickle cell anemia, Sickle cell disease, Sickle cell trait, Amino acid disorders, Argininosuccinic aciduria, Citrullinemia, ... Congenital Adrenal Hyperplasia, CAH, Newborn, Newborn screening, Newborn screens, Expanded screening, Expanded newborn ... CCHD is the name given to specific congenital heart defects. These defects in the heart occur before birth, cause blood to flow ... These include: hypoplastic left heart syndrome, pulmonary atresia, tetralogy of fallot, total anomalous pulmonary venous return ...

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... congenital amegakaryocytic thrombocytopenia, severe congenital neutropenia, and Diamond-Blackfan anemia with a focus on ... Herein we review several overlapping acquired marrow failure entities including aplastic anemia, hypoplastic myelodysplasia, ... Anemia Aplástica/complicações , Medula Óssea/patologia , Mutação em Linhagem Germinativa/genética , Células Germinativas , ...

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Congenital aplastic anemia, myelofibrosis and the hypoplastic anemias due to the administration of. Hemathologic risk of ... Hemolytic anemia: anemia due to the destruction, rather than underproduction, of red blood cells. Hemolytic anemia can result ... Anabolic steroids for anemia. Sometimes doctors prescribe anabolic steroids to help people with certain kinds of anemia and men ... Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body ...

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Anemia, Aplastic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
This graph shows the total number of publications written about "Anemia, Aplastic" by people in UAMS Profiles by year, and whether "Anemia, Aplastic" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Anemia, Aplastic" by people in Profiles over the past ten years. (uams.edu)
Cai B, Said Q, Li X, Li FY, Arcona S. Healthcare resource use and direct costs in severe aplastic anemia (SAA) patients before and after treatment with eltrombopag. (uams.edu)
Aplastic Anemia in Two Patients with Sex Chromosome Aneuploidies. (uams.edu)
Acquired aplastic anemia, congenital aplastic. (bulletizers.in)
This report* was developed to assist physicians, public health officials, and other health-care professionals respond to public concerns about recently recognized, serious complications of human parvovirus B19 (B19) infection, including transient aplastic crisis (TAC), chronic anemia, and fetal death. (cdc.gov)
Men who have been on testosterone for long periods of time and who are not careful about their testosterone will experience a decrease in their ability to have or maintain a satisfactory erection, anabolic steroids in aplastic anemia. (festaditeatroecologico.com)
Acquired aplastic anemia, congenital aplastic anemia, myelofibrosis and the hypoplastic anemias due to the administration of myelotoxic drugs often respond, parabolan dosering. (flowingspineyoga.com)
Patients with aplastic anemia are considered contagious before the onset of symptoms and for at least 1 week. (medscape.com)
Although B19V infection may manifest with pancytopenia, it is not believed to contribute significantly as an etiology of true aplastic anemia. (medscape.com)
Vitamin b12 deficiency, iron deficiency iron deficiency chest chield chest dimondblackfan syndrome hands triphalangeal thumbs hypoplastic of thenar eminence spoon nails pure red cell aplasia fanconis aplastic anemia iron deficiency spleen enlargement congenital hemolytic anemia. (firebaseapp.com)
Furthermore, aplastic anemia may develop later in life. (medscape.com)

For primary (Addison's disease) or secondary adrenocortical insufficiency or for the treatment of congenital adrenal hyperplasia. (pdr.net)

Bone marrows of hospitalized children with anaemia were examined to study the incidence and profile of erythroblastopenia in childhood. (who.int)
Forty children aged between 7 months to 12 years with anaemia, reticulocytopenia and isolated erythroblastopenia on Bone marrow aspiration were evaluated during 2 years duration. (who.int)
Idiophatic thrombocytopenia purpura and secondary thrombocytopenia in adults, acquired (autoimmune) haemolytic anaemia, erythroblastopenia, and congenital hypoplastic anaemia. (infionpharma.com)

Since its discovery, B19 has been shown to be the causative agent of erythema infectiosum (EI) (also known as fifth disease) and is the primary etiologic agent of TAC in patients with chronic hemolytic anemias (2-4). (cdc.gov)
B19 is the primary etiologic agent causing TAC in patients with chronic hemolytic anemias (e.g., sickle cell disease, hemoglobin SC disease, hereditary spherocytosis, alpha-thalassemia, and autoimmune hemolytic anemia) (22,23). (cdc.gov)
Although decreases in hemoglobin levels of greater than 1 g/dL are rare in healthy children infected with parvovirus B19, decreases of 2-6 g/dL may be observed in patients with hemoglobinopathies or hemolytic anemias. (medscape.com)

Hundred cases of microcytic mcv anemia hb deficiency anemia fe deficiency excluded anemia ferritin 33270 pmoll high normal or low fe absent fe present 29 anemia workup mcv iron deficiency anemia of chronic disease thalassemias hemoglobinopathies sideroblastic anemia microcytic anemia of chronic disease early iron deficiency hemoglobinopathies primary marrow disorders combined. (firebaseapp.com)

These include: hypoplastic left heart syndrome, pulmonary atresia, tetralogy of fallot, total anomalous pulmonary venous return, transposition of the great arteries, tricuspid atresia, and truncus arterious. (mo.gov)
Please do not use anadrol-50 tablet for acquired immune deficiency syndrome and anemia without consulting first with your doctor. (anastasiaevents.com)
Patients with ataxia telangiectasia, also known as Louis-Bar syndrome, are hypersensitive to ionizing radiation, while patients with Bloom syndrome, Fanconi anemia, and xeroderma pigmentosum are sensitive to UV radiation. (medscape.com)
This is a syndrome of congenital anomalies that includes vertebral dysgenesis, anal atresia with or without fistula, cardiac defects (ventricular septal defect [VSD]), tracheoesophageal fistula, and renal and limb anomalies. (medscape.com)

Diamond-Blackfan anemia is a disorder that primarily affects the bone marrow. (medlineplus.gov)
Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. (ouhsc.edu)

Pernicious anaemia pa is a disease of the stomach that is characterised by megaloblastic anaemia due to vitamin b12 deficiency. (firebaseapp.com)

B19 has also been associated with fetal death (both spontaneous abortions and stillbirths), acute arthralgias and arthritis, and chronic anemia in immunodeficient patients (5-14). (cdc.gov)
Adverse Maternal Fetal Environment Partially Mediates Disparate Outcomes in Non-White Neonates with Major Congenital Heart Disease. (ucsf.edu)

In children and adults with severe chronic neutropenia (severe congenital, periodic and malignant neutropenia), the drug stably increases the number of peripheral blood neutrophilic granulocytes and reduces the incidence of infectious complications. (mysalve.com)
With prolonged therapy aimed at increasing the number of neutrophilic granulocytes, to reduce the frequency and duration of infectious complications in children and adults with severe congenital, periodic or malignant neutropenia (the absolute number of neutrophilic granulocytes is 500 in 1 mm 3 ) and with severe or recurring infections in the anamnesis. (mysalve.com)
The World Health Organization (WHO) criterion for anemia in adults is a hemoglobin (Hb) value of less than 12.5 g/dL. (medscape.com)

Approximately half of individuals with Diamond-Blackfan anemia have physical abnormalities. (medlineplus.gov)

Anaemia in the tropics is usually regarded as secondary to some tropical disease, such as the haemolysis of malaria and the blood sucking of hookworms. (firebaseapp.com)

Severe Congenital Neutropenia: neutropenia, pyogenic infections, bone marrow maturation arrest. (clinicaltrials.gov)

Many rare or uncommon diseases have iron overload or anemia as a consequence of the disease itself or the treatment (blood transfusion or iron infusion). (irondisorders.org)

The manifestations of TAR and Fanconi anemia frequently overlap. (medscape.com)

For anemia and osteoporosis without the side effects of oxymetholone. (bulletizers.in)
Anadrol (oxymetholone) is a medication used to treat anemia. (russlacasse.com)

Many types of anemia exist, such as iron deficiency. (firebaseapp.com)

Anadrol-50 is indicated in the treatment of anemias caused by deficient red cell production. (bulletizers.in)
Anadrol tablets are called anadrol-50, which are used for anemia in the. (bulletizers.in)
Anadrol-50 is a prescription medicine used to treat the symptoms of anemia caused by deficient red cell production. (thccollections.com)
Envíos gratis en el día ✓ comprá anadrol 50 mg pura potencia en cuotas sin interés! (thccollections.com)
Anadrol 50 es un producto oral que los culturistas suelen utilizar en un ciclo de esteroides. (thccollections.com)
Si manger sain et équilibré est primordial pour rester en bonne santé, ça l’est également pour votre vie sexuelle et votre libido, anadrol 50 india. (uncommonmovement.net)
You need to look out for certain signs that may signify low testosterone levels, anadrol 50 precio en méxico. (uncommonmovement.net)

Irondeficiency anemia is a more severe condition in which low levels of iron are associated with anemia and the presence of microcytic hypochromic red cells. (firebaseapp.com)

In Diamond-Blackfan anemia, the bone marrow malfunctions and fails to make enough red blood cells, which carry oxygen to the body's tissues. (medlineplus.gov)
People with Diamond-Blackfan anemia have an increased risk of several serious complications related to their malfunctioning bone marrow. (medlineplus.gov)
Individuals with Diamond-Blackfan anemia also have an increased risk of developing a bone marrow cancer known as acute myeloid leukemia (AML), a type of bone cancer called osteosarcoma, and other cancers. (medlineplus.gov)
The severity of Diamond-Blackfan anemia may vary, even within the same family. (medlineplus.gov)
Increasingly, individuals with "non-classical" Diamond-Blackfan anemia have been identified. (medlineplus.gov)
Diamond-Blackfan anemia affects approximately 5 to 7 per million newborn babies worldwide. (medlineplus.gov)
Diamond-Blackfan anemia can be caused by mutations in one of many genes, including the RPL5 , RPL11 , RPL35A , RPS10 , RPS17 , RPS19 , RPS24 , and RPS26 genes. (medlineplus.gov)
These and other genes associated with Diamond-Blackfan anemia provide instructions for making ribosomal proteins, which are components of cellular structures called ribosomes . (medlineplus.gov)
Approximately 25 percent of individuals with Diamond-Blackfan anemia have mutations in the RPS19 gene. (medlineplus.gov)
Abnormal regulation of cell division or inappropriate triggering of apoptosis may contribute to the other health problems that affect some people with Diamond-Blackfan anemia. (medlineplus.gov)

Thrombopoietin in patients with congenital thrombocytopenia and absent radii: elevated serum levels, normal receptor expression, but defective reactivity to thrombopoietin. (medscape.com)
Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii. (medscape.com)

Anemia of chronic disease acd may coexist with an element of true iron deficiency. (firebaseapp.com)

Sometimes doctors prescribe anabolic steroids to help people with certain kinds of anemia and men who do not produce enough testosterone on their ownwill also try them as part of a men's steroid program. (festaditeatroecologico.com)
If it becomes so severe that it becomes obvious it is causing problems for the patient, then they should seek medical attention for it immediately, anabolic steroids for anemia. (festaditeatroecologico.com)
For this reason, they should only take testosterone that has been proven appropriate for their needs before deciding on which medication to use for treatment, steroids and iron deficiency anemia. (festaditeatroecologico.com)
Anabolic steroids are now only available to treat medical conditions such as delayed puberty, endometriosis, and even anemia in some cases. (festaditeatroecologico.com)

Iron deficiency with and without anemia are a key focus areas for Iron Disorders Institute. (irondisorders.org)
Iron deficiency anemia hematology and oncology msd manual. (firebaseapp.com)
Regardless of the cause be it from low dietary intake of iron or via excessive blood loss, iron deficiency anemia has the following signs and symptoms, which are linked to the essential functions of iron in. (firebaseapp.com)
Diagnosis and management of iron deficiency anaemia. (firebaseapp.com)
Bleeding is a leading cause of iron deficiency anemia. (firebaseapp.com)
Social and biological determinants of iron deficiency anemia. (firebaseapp.com)
Iron deficiency anemia is almost always due to blood loss. (firebaseapp.com)
Iron deficiency anemia is a condition that develops from having insufficient iron levels in the body resulting in fewer and smaller red blood cells containing lower amounts of hemoglobin. (firebaseapp.com)
Iron deficiency anemia has been shown to increase the risk of low birthweight and possibly preterm birth. (firebaseapp.com)
Iron deficiency is one of several causes of low haemoglobin, and causes iron deficiency anaemia ida. (firebaseapp.com)
Global burden of iron deficiency anaemia in the year 2000. (firebaseapp.com)
Prevalence of iron deficiency anaemia in global view. (firebaseapp.com)
Iron deficiency continues to be a major health issue worldwide and iron deficiency anaemia is associated with welldocumented adverse health outcomes. (firebaseapp.com)
Iron deficiency anemia ida constitutes the major anemia during. (firebaseapp.com)
Iron deficiency refers to the reduction of iron stores that precedes overt irondeficiency anemia or persists without progression. (firebaseapp.com)
Iron deficiency anaemia ida remains prevalent in australia and worldwide, especially among highrisk groups. (firebaseapp.com)

Point-of-care technologies are emerging as a portable and convenient method of screening for anemia that is particularly appropriate for low- and middle-income countries, where anemia is most prevalent. (medscape.com)

Ravilla R, Joiner AK, Alapat D, Arnaoutakis K. An Unusual Case of Acute Promyelocytic Leukemia Presenting With Hypoplastic Bone Marrow and Pancytopenia. (uams.edu)
With anemia due to acute blood loss, a reduction in oxygen-carrying capacity occurs along with a decrease in intravascular volume, with resultant hypoxia and hypovolemia. (medscape.com)

Often, the etiology of a patient's anemia can be determined if the red blood cells (RBCs) are altered in either size or shape or if they contain certain inclusion bodies. (medscape.com)
Anemia, like a fever, is a sign that requires investigation to determine the underlying etiology. (medscape.com)
The purpose of this article is to provide a method of determining the etiology of an anemia. (medscape.com)

The most serious complications of severe anemia arise from tissue hypoxia. (medscape.com)
Although it is improving with the more severe anemia. (aaan.org)

Effective January 1, 2014, state law mandates screening all infants born in Missouri for critical congenital heart disease (CCHD) through pulse oximetry screening. (mo.gov)

For example, some affected individuals have mild anemia beginning later in childhood or in adulthood, while others have some of the physical features but no bone marrow problems. (medlineplus.gov)
Studies indicate that a shortage of functioning ribosomes may increase the self-destruction of blood-forming cells in the bone marrow, resulting in anemia. (medlineplus.gov)
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. (uams.edu)

Anemia caused by deficient red cell production. (thccollections.com)
It can also cause TAC in other conditions in which increased red cell production is necessary to maintain stable red cell indices, as may occur in anemia due to blood loss. (cdc.gov)
The Sickle Cell Anemia Program provides information to the public and health professionals about sickle cell anemia and sickle cell trait, and promotes and provides screening, referral, counseling and follow-up services for Missouri citizens at risk for sickle cell disease. (mo.gov)
Conditions with an increase in plasma volume, such as during the last trimester of pregnancy, are associated with lower values without an existent anemia, because the red cell mass is normal. (medscape.com)
Anemia is strictly defined as a decrease in red blood cell (RBC) mass. (medscape.com)

The disease was found to be associated with PEM and nutritional anaemia (55%), gastroenteritis (12.5%) and respiratory tract infections (12.5%) amongst others. (who.int)
The first step in the diagnosis of anemia is detection with reliable, accurate tests so that important clues to underlying disease are not overlooked and patients are not subjected to unnecessary tests for and treatment of nonexistent anemia. (medscape.com)
Treatment congenital toxoplasmosis in active disease more common problems that may progress to joint destruction ie, hemophilic arthropathy. (aaan.org)

realizando el tratamiento de rejuvenecimiento facial con péptidos con resultados muy buenos sobre todo en pieles muy castigadas, valori ottimali testosterone uomo. (activistcareproject.com)

CCHD is the name given to specific congenital heart defects. (mo.gov)

In anemia, a decrease in the number of RBCs transporting oxygen and carbon dioxide impairs the body's ability for gas exchange. (medscape.com)

Diagnostic approach to anemia arup university of utah. (firebaseapp.com)

Often, practicing physicians overlook mild anemia. (medscape.com)

Anemia types and characteristic finding classification of. (firebaseapp.com)

Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the. (firebaseapp.com)

Anemia is suggested in males with Hb levels less than 13.5 g/dL and in females with Hb levels less than 12.5 g/dL. (medscape.com)
Use in males: for management of congenital or. (sagradafeminidad.com)

Anatomy8

Organisms6

Diseases53

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology1

Phenomena and Processes16

Technology, Industry, Agriculture2

Information Science1

Named Groups1

Health Care9

Geographicals3

Neutrophil functions in patients with inherited bone marrow failure syndromes. (1/1)

Anemia

Anemia, Aplastic

Anemia, Hemolytic

Fanconi Anemia

Anemia, Hemolytic, Autoimmune

Anemia, Hypochromic

Anemia, Macrocytic

Anemia, Pernicious

Anemia, Sickle Cell

Anemia, Sideroblastic

Anemia, Megaloblastic

Infectious Anemia Virus, Equine

Hemoglobins

Anemia, Refractory

Anemia, Hemolytic, Congenital

Equine Infectious Anemia

Erythropoietin

Chicken anemia virus

Anemia, Dyserythropoietic, Congenital

Anemia, Diamond-Blackfan

Fanconi Anemia Complementation Group Proteins

Iron

Pregnancy Complications, Hematologic

Anemia, Neonatal

Hematinics

Anemia, Refractory, with Excess of Blasts

Fanconi Anemia Complementation Group C Protein

Fanconi Anemia Complementation Group D2 Protein

Hematocrit

Fanconi Anemia Complementation Group A Protein

Erythropoiesis

Anemia, Hemolytic, Congenital Nonspherocytic

Pallor

Erythrocyte Count

Ferritins

Erythrocyte Indices

Hemoglobinometry

Blood Transfusion

Erythrocytes

Fanconi Anemia Complementation Group G Protein

Coombs Test

Reticulocyte Count

Iron, Dietary

Iron Compounds

Hepcidins

Erythrocytes, Abnormal

Erythrocyte Transfusion

Prevalence

Vitamin B 12 Deficiency

Erythrocyte Aging

Bone Marrow

beta-Thalassemia

Isavirus

Pancytopenia

Thalassemia

Fanconi Anemia Complementation Group F Protein

Phenylhydrazines

Fanconi Anemia Complementation Group E Protein

Fetal Hemoglobin

Malaria

Blood Cell Count

Treatment Outcome

Folic Acid Deficiency

Pregnancy

Vitamin B 12

Horses

Splenomegaly

Erythroblasts

Osmotic Fragility

Reticulocytes

Antilymphocyte Serum

Parasitemia

Risk Factors

Ferrous Compounds

Recombinant Proteins

Iron Overload

Kidney Failure, Chronic

Mitomycin

Heinz Bodies

Hookworm Infections