Anemia hemolytic. Medical search

A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).

Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.

Hemolytic anemia due to various intrinsic defects of the erythrocyte.

The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.

A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.

Substances that are toxic to blood in general, including the clotting mechanism; hematotoxins may refer to the hematopoietic system.

Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)

Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte. Common causes include deficiencies in GLUCOSE-6-PHOSPHATE ISOMERASE; PYRUVATE KINASE; and GLUCOSE-6-PHOSPHATE DEHYDROGENASE.

A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.

Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)

Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).

A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)

A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.

Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. Biosynthesis may be regulated by HEMOLYSIN FACTORS.

The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.

Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow.

Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.

A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.

A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS.

A species of LENTIVIRUS, subgenus equine lentiviruses (LENTIVIRUSES, EQUINE), causing acute and chronic infection in horses. It is transmitted mechanically by biting flies, mosquitoes, and midges, and iatrogenically through unsterilized equipment. Chronic infection often consists of acute episodes with remissions.

A severe sometimes chronic anemia, usually macrocytic in type, that does not respond to ordinary antianemic therapy.

A screening assay for circulating COMPLEMENT PROTEINS. Diluted SERUM samples are added to antibody-coated ERYTHROCYTES and the percentage of cell lysis is measured. The values are expressed by the so called CH50, in HEMOLYTIC COMPLEMENT units per milliliter, which is the dilution of serum required to lyse 50 percent of the erythrocytes in the assay.

Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.

A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)

Viral disease of horses caused by the equine infectious anemia virus (EIAV; INFECTIOUS ANEMIA VIRUS, EQUINE). It is characterized by intermittent fever, weakness, and anemia. Chronic infection consists of acute episodes with remissions.

A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.

Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)

The type species of GYROVIRUS, a small, non-enveloped DNA virus originally isolated from contaminated vaccines in Japan. It causes chicken infectious anemia and may possibly play a key role in hemorrhagic anemia syndrome, anemia dermatitis, and blue wing disease.

A group of familial congenital hemolytic anemias characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.

A familial disorder characterized by ANEMIA with multinuclear ERYTHROBLASTS, karyorrhexis, asynchrony of nuclear and cytoplasmic maturation, and various nuclear abnormalities of bone marrow erythrocyte precursors (ERYTHROID PRECURSOR CELLS). Type II is the most common of the 3 types; it is often referred to as HEMPAS, based on the Hereditary Erythroblast Multinuclearity with Positive Acidified Serum test.

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.

Abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells. They are seen in thalassemias, enzymopathies, hemoglobinopathies, and after splenectomy.

The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.

A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)

A diverse group of proteins whose genetic MUTATIONS have been associated with the chromosomal instability syndrome FANCONI ANEMIA. Many of these proteins play important roles in protecting CELLS against OXIDATIVE STRESS.

The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.

The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.

The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.

The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.

RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.

The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.

Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.

The mildest form of erythroblastosis fetalis in which anemia is the chief manifestation.

The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)

A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.

Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.

Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.

ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).

The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.

A Fanconi anemia complementation group protein that regulates the activities of CYTOCHROME P450 REDUCTASE and GLUTATHIONE S-TRANSFERASE. It is found predominately in the CYTOPLASM, but moves to the CELL NUCLEUS in response to FANCE PROTEIN.

Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.

A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.

A Fanconi anemia complementation group protein that is the most commonly mutated protein in FANCONI ANEMIA. It undergoes PHOSPHORYLATION by PROTEIN KINASE B and forms a complex with FANCC PROTEIN in the CELL NUCLEUS.

Measurement of hemoglobin concentration in blood.

Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).

Exotoxins produced by certain strains of streptococci, particularly those of group A (STREPTOCOCCUS PYOGENES), that cause HEMOLYSIS.

Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.

A clinical manifestation consisting of an unnatural paleness of the skin.

The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.

An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

A toxin produced by SHIGELLA DYSENTERIAE. It is the prototype of class of toxins that inhibit protein synthesis by blocking the interaction of ribosomal RNA; (RNA, RIBOSOMAL) with PEPTIDE ELONGATION FACTORS.

An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).

Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.

Surgical procedure involving either partial or entire removal of the spleen.

Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.

Enlargement of the spleen.

Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.

Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.

The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.

The process by which fetal Rh+ erythrocytes enter the circulation of an Rh- mother, causing her to produce IMMUNOGLOBULIN G antibodies, which can cross the placenta and destroy the erythrocytes of Rh+ fetuses. Rh isoimmunization can also be caused by BLOOD TRANSFUSION with mismatched blood.

Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.

A Fanconi anemia complementation group protein that undergoes PHOSPHORYLATION by CDC2 PROTEIN KINASE during MITOSIS. It forms a complex with other FANCONI ANEMIA PROTEINS and helps protect CELLS from DNA DAMAGE by genotoxic agents.

A subnormal level of BLOOD PLATELETS.

Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.

Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.

A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.

Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.

A class of Echinodermata characterized by long, slender bodies.

Stable chromium atoms that have the same atomic number as the element chromium, but differ in atomic weight. Cr-50, 53, and 54 are stable chromium isotopes.

A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.

Small, abnormal spherical red blood cells with more than the normal amount of hemoglobin.

Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.

Infections with bacteria of the species ESCHERICHIA COLI.

A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.

In utero transfusion of BLOOD into the FETUS for the treatment of FETAL DISEASES, such as fetal erythroblastosis (ERYTHROBLASTOSIS, FETAL).

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A verocytotoxin-producing serogroup belonging to the O subfamily of Escherichia coli which has been shown to cause severe food-borne disease. A strain from this serogroup, serotype H7, which produces SHIGA TOXINS, has been linked to human disease outbreaks resulting from contamination of foods by E. coli O157 from bovine origin.

The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.

Organic and inorganic compounds that contain iron as an integral part of the molecule.

Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.

Hemolytic anemia due to the ingestion of fava beans or after inhalation of pollen from the Vicia fava plant by persons with glucose-6-phosphate dehydrogenase deficient erythrocytes.

Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)

The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.

The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.

Proteins prepared by recombinant DNA technology.

A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.

A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.

A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.

The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.

Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.

An infant during the first month after birth.

The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.

A toxin produced by certain pathogenic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157. It shares 50-60% homology with SHIGA TOXIN and SHIGA TOXIN 1.

Disorders of the blood and blood forming tissues.

A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.

A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)

C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.

A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

An encapsulated lymphatic organ through which venous blood filters.

An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE production. Reticulocytosis occurs during active BLOOD regeneration (stimulation of red bone marrow) and in certain types of ANEMIA, particularly CONGENITAL HEMOLYTIC ANEMIA.

A toxin produced by certain pathogenic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157. It is closely related to SHIGA TOXIN produced by SHIGELLA DYSENTERIAE.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.

A genus in the family ORTHOMYXOVIRIDAE containing one species: Infectious salmon anemia virus.

Elements of limited time intervals, contributing to particular results or situations.

Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)

Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.

A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.

Strains of ESCHERICHIA COLI with the ability to produce at least one or more of at least two antigenically distinct, usually bacteriophage-mediated cytotoxins: SHIGA TOXIN 1 and SHIGA TOXIN 2. These bacteria can cause severe disease in humans including bloody DIARRHEA and HEMOLYTIC UREMIC SYNDROME.

A Fanconi anemia complementation group protein. It is an essential component of a nuclear core complex that protects the GENOME against CHROMOSOMAL INSTABILITY. It interacts directly with FANCG PROTEIN and helps stabilize a complex with FANCA PROTEIN and FANCC PROTEIN.

Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production.

Proteins found in any species of bacterium.

A Fanconi anemia complementation group protein that interacts with FANCC PROTEIN and FANCD2 PROTEIN. It promotes the accumulation of FANCC protein in the CELL NUCLEUS.

A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B.

Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

Plasmids controlling the synthesis of hemolysin by bacteria.

Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.

The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children.

A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

Virus infections caused by the PARVOVIRIDAE.

Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.

Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.

An individual in which both alleles at a given locus are identical.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

An intrinsic defect of erythrocytes inherited as an autosomal dominant trait. The erythrocytes assume an oval or elliptical shape.

A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

A bile pigment that is a degradation product of HEME.

An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.

Endogenous proteins that inhibit or inactivate COMPLEMENT C3B. They include COMPLEMENT FACTOR H and COMPLEMENT FACTOR I (C3b/C4b inactivator). They cleave or promote the cleavage of C3b into inactive fragments, and thus are important in the down-regulation of COMPLEMENT ACTIVATION and its cytolytic sequence.

Venoms produced by FISHES, including SHARKS and sting rays, usually delivered by spines. They contain various substances, including very labile toxins that affect the HEART specifically and all MUSCLES generally.

Glycosphingolipids which contain as their polar head group a trisaccharide (galactose-galactose-glucose) moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in ceramide trihexosidase, is the cause of angiokeratoma corporis diffusum (FABRY DISEASE).

Plasma glycoproteins that form a stable complex with hemoglobin to aid the recycling of heme iron. They are encoded in man by a gene on the short arm of chromosome 16.

Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.

The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.

Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.

Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).

Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.

A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.

Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.

A genus of large SEA CUCUMBERS possessing the primitive radial configuration of podia in all five ambulacral areas.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)

Inorganic or organic compounds that contain divalent iron.

A subspecialty of internal medicine concerned with morphology, physiology, and pathology of the blood and blood-forming tissues.

An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

The condition of being heterozygous for hemoglobin S.

Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.

Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.

Specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS.

Substances that reduce the growth or reproduction of BACTERIA.

Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.

A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.

A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs singly, in pairs, or in short chains. Its organisms are found in fresh water and sewage and are pathogenic to humans, frogs, and fish.

Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.

A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.

A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431)

A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.

Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.

The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

Volume of circulating ERYTHROCYTES . It is usually measured by RADIOISOTOPE DILUTION TECHNIQUE.

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

Venoms from jellyfish; CORALS; SEA ANEMONES; etc. They contain hemo-, cardio-, dermo- , and neuro-toxic substances and probably ENZYMES. They include palytoxin, sarcophine, and anthopleurine.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

A glycoprotein secreted by the cells of the GASTRIC GLANDS that is required for the absorption of VITAMIN B 12 (cyanocobalamin). Deficiency of intrinsic factor leads to VITAMIN B 12 DEFICIENCY and ANEMIA, PERNICIOUS.

A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a cofactor for their inactivation. CD46 also interacts with a wide variety of pathogens and mediates immune response.

The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.

Serum proteins that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is potentially dangerous for the host. The complement system is tightly regulated by inactivators that accelerate the decay of intermediates and certain cell surface receptors.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Extraction of erythrocyte membrane proteins by sulfhydryl inhibitors. (1/616)

Human red cell membrane proteins were extracted by incubation of the ghost with hypotonic phosphate buffer (pH 7.4), N-ethylmaleimide and p-hydroxy-mercuribenzoate. In paroxysmal nocturnal hemoglobinuria (PNH), hereditary spherocytosis (HS) and hereditary elliptocytosis, the amount of proteins extracted by these procedures was significantly less than the amount extractable from the ghost of normal and aplastic anemia red cells. Polypeptide patterns of red cell membranes in these hematological disorders were essentially similar to those of normal ghosts. Analysis of the supernatant by SDS polyacrylamide gel electrophoresis revealed that this reduction was mainly due to the reduced amount of peripheral proteins extracted. The extraction of peripheral proteins by sulfhydryl reagents was accompanied by shape changes resulting in the formation of membrane vesicles, suggesting an important role of peripheral proteins in the maintenance of ghost shape. It is also suggested that qualitative abnormalities of peripheral proteins such as altered reactivity to sulfhydryl reagents and/or strong binding to the membrane are present in PNH, HS and hereditary elliptocytosis red cells. (+info)

Reduced glutathione accelerates the oxidative damage produced by sodium n-propylthiosulfate, one of the causative agents of onion-induced hemolytic anemia in dogs. (2/616)

The oxidative effects of sodium n-propylthiosulfate, one of the causative agents of onion-induced hemolytic anemia in dogs, were investigated in vitro using three types of canine erythrocytes, which are differentiated by the concentration of reduced glutathione and the composition of intracellular cations. After incubation with sodium n-propylthiosulfate, the methemoglobin concentration and Heinz body count in all three types of erythrocytes increased and a decrease in the erythrocyte reduced glutathione concentration was then observed. The erythrocytes containing high concentrations of potassium and reduced glutathione (approximately five times the normal values) were more susceptible to oxidative damage by sodium n-propylthiosulfate than were the normal canine erythrocytes. The susceptibility of the erythrocytes containing high potassium and normal reduced glutathione concentrations was intermediate between those of erythrocytes containing high concentrations of potassium and reduced glutathione and normal canine erythrocytes. In addition, the depletion of erythrocyte reduced glutathione by 1-chloro-2, 4-dinitrobenzene resulted in a marked decrease in the oxidative injury induced by sodium n-propylthiosulfate in erythrocytes containing high concentrations of potassium and reduced glutathione. The generation of superoxide in erythrocytes containing high concentrations of potassium and reduced glutathione was 4.1 times higher than that in normal canine erythrocytes when the cells were incubated with sodium n-propylthiosulfate. These observations indicate that erythrocyte reduced glutathione, which is known as an antioxidant, accelerates the oxidative damage produced by sodium n-propylthiosulfate. (+info)

Rumen bacteria are involved in the onset of onion-induced hemolytic anemia in sheep. (3/616)

The mechanism of onion-induced hemolytic anemia in ruminants was investigated. The ether-extract obtained from the mixture of rumen fluid and onion juice incubated at 38.5 degrees C for 9 hr induced oxidative damage in sheep erythrocytes in vitro, indicating the production of certain oxidants in the mixture. The increase of the oxidative effect in the mixture was inhibited completely by the removal of rumen microorganisms and partly by treatment with antibiotics and by oxygen gas. The sheep fed onions (50 g/kg body weight/day) for 15 days developed more severe Heinz body hemolytic anemia than did the sheep fed the equivalent amount of onions with 5 g/day ampicillin sodium salt. The results indicated that certain rumen bacteria appear to be involved in the onset of onion-induced hemolytic anemia in sheep. (+info)

Erythroid accelerating activity of rat serum in early stage of drug induced hemolysis. (4/616)

An increase in the number of erythroblasts can be seen to some extent in the bone marrow of rats in the early stage of experimentally induced hemolytic anemia prior to any elevation in the plasma erythropoietin (Epo) level. This observation suggests that there is another erythroid stimulating factor present other than Epo. We studied the enhancing effect of serum, taken sequentially during experimentally induced hemolysis in rats, on erythroid proliferation, differentiation and maturation in vitro. Single intraperitoneal injection of 60 mg/kg of acetylphenylhydrazine (APH) induced self-limited hemolytic anemia in rats, in which the hematocrit dropped rapidly with a nadir at day 4 after APH injection, followed by a gradual increase with return to normal level by day 8. Serum obtained consecutively every day after APH injection from day 1 to day 7 was applied to an in vitro culturing system of erythroid progenitors. Addition of day 1 serum, in which an elevation of Epo level had not occurred, to a conventional methyl-cellulose culture of rat bone marrow mononuclear cells (BM-MNCs) resulted in a significant increase in the number of colonies derived from colony forming unit erythroid, but not in burst forming unit erythroid. This erythropoietic activity of the serum was particularly evident in the presence of Epo. In the liquid culture of BM-MNCs, day 1 serum also showed some enhancing effect on erythroblast formation. We were able to see significant differences in these erythroid enhancing activities induced by serum drawn on day 1 in comparison to the serum drawn on subsequent days. These results suggest that an unknown erythroid enhancing factor besides Epo stimulates erythropoiesis in the early stage of hemolytic anemia or sudden hypoxia before there is a measurable rise in the serum Epo level. We propose that this factor be termed erythroid accelerating factor (EAF). (+info)

Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation. (5/616)

BACKGROUND: Following orthotopic liver transplantation (OLT) histological examination of explant livers from patients with alcoholic liver disease (ALD) sometimes shows extensive iron deposits in a distribution suggestive of homozygous haemochromatosis. AIMS: To use haemochromatosis gene (HFE) assays to distinguish between ALD with notable siderosis and hereditary haemochromatosis. To evaluate the possible influence of spur cell haemolytic anaemia on hepatic iron loading. PATIENTS: Thirty seven patients with ALD were abstinent for at least six months prior to OLT. Twenty three patients had transferrin saturations greater than 55%, 16 also had increased serum ferritin (>350 micrograms/l). Eight of 37 (22%) explant livers had grade 3 or 4 hepatic iron deposition, predominantly in hepatocytes. Of these, four had a hepatic iron index greater than 1. 9 and most seemed to have spur cell haemolytic anaemia. METHODS: Mutation analysis for C282Y and H63D mutations was performed on DNA extracts from peripheral blood or explant liver. Spur cell haemolytic anaemia was diagnosed when the haemoglobin was 105 g/l in the presence of notable acanthocytosis. RESULTS: None of the eight patients with grade 3 or 4 hepatic iron had evidence of the C282Y mutation. Two of the eight were heterozygous for H63D. None of the remaining 28 patients tested showed homozygous HFE mutations. Spur cell anaemia was present in six of the eight patients with heavy iron deposition and only one of the remaining patients. CONCLUSIONS: The HFE mutation was not present in these patients with advanced ALD and heavy iron loading. Spur cell haemolytic anaemia provides an alternative potential mechanism for the heavy iron loading. (+info)

The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency. (6/616)

Gamma-glutamylcysteine synthetase catalyzes the first step in glutathione synthesis. The enzyme consists of 2 subunits, heavy and light, with the heavy subunit serving as the catalytic subunit. A patient with hemolytic anemia and low red blood cell glutathione levels was found to have a deficiency of gamma-glutamylcysteine synthetase activity. Examination of cDNA from the patient and her mother showed that she was homozygous and that her mother was heterozygous for a A-->T transversion at nt1109 producing a deduced amino acid change of His370Leu. The partial genomic structure of the catalytic subunit of gamma-glutamylcysteine synthetase (GLCLC) was determined, providing some intron/exon boundaries to make it possible to sequence an affected part of the coding region from genomic DNA. The 1109A-->T mutation was not present in the DNA of 38 normal subjects. In the course of these studies we found a diallelic polymorphism in nt +206 of an intron and another polymorphism that consisted of a duplication of a CAGC at cDNA nt1972-1975 in the 3' untranslated region. The 2 polymorphisms were found to be only in partial linkage disequilibrium. (+info)

Molecular basis and enzymatic properties of glucose 6-phosphate dehydrogenase volendam, leading to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections. (7/616)

We have investigated the blood cells from a woman with a low degree of chronic nonspherocytic hemolytic anemia and frequent bacterial infections accompanied by icterus and anemia. The activity of glucose 6-phosphate dehydrogenase (G6PD) in her red blood cells (RBCs) was below detection level, and in her leukocytes less than 3% of normal. In cultured skin fibroblasts, G6PD activity was approximately 15% of normal, with 4- to 5-fold increased Michaelis constant (Km) for NADP and for glucose 6-phosphate. Activated neutrophils showed a decreased respiratory burst. Family studies showed normal G6PD activity in the RBCs from all family members, including both parents and the 2 daughters of the patient. Sequencing of polymerase chain reaction (PCR)-amplified genomic DNA showed a novel, heterozygous 514C-->T mutation, predicting a Pro172-->Ser replacement. Analysis of G6PD RNA from the patient's leukocytes and fibroblasts showed only transcripts with the 514C-->T mutation. This was explained by the pattern of X-chromosome inactivation, studied by means of the human androgen receptor (HUMARA) assay, which proved to be skewed in the patient, her mother, and one of the patient's daughters. Thus, the patient has inherited a de novo mutation in G6PD from her father and an X-chromosome inactivation determinant from her mother, causing exclusive expression of the mutated G6PD allele. Purified mutant protein from an Escherichia coli expression system showed strongly decreased specific activity, increased Km for NADP and for glucose 6-phosphate, and increased heat lability, which indicates that the defective phenotype is due to 2 synergistic molecular dysfunctions: decreased catalytic efficiency and protein instability. (+info)

Reversal of metabolic block in glycolysis by enzyme replacement in triosephosphate isomerase-deficient cells. (8/616)

Inherited deficiency of the housekeeping enzyme triosephosphate isomerase (TPI) is the most severe clinical disorder of glycolysis. Homozygotes manifest congenital hemolytic anemia and progressive neuromuscular impairment, which in most cases pursues an inexorable course with fatal outcome in early childhood. No effective therapy is available. Hitherto specific enzyme replacement has not been attempted in disorders of glycolysis. Primary skeletal muscle myoblasts and Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines generated from homozygous TPI-deficient patients were cultured in the presence of exogenous enzyme or cocultured with human K562 erythroleukemia cells as an exogenous source of TPI. Uptake of active enzyme by TPI-deficient cells resulted in reversal of intracellular substrate accumulation, with a reduction in dihydroxyacetone phosphate (DHAP) concentration to levels seen in TPI-competent cells. Evidence of successful metabolic correction of TPI deficiency in vitro establishes the feasibility of enzyme replacement therapy, and has important implications for the potential role of allogeneic bone marrow transplantation and gene therapy as a means of sustained delivery of functional enzyme in vivo. (+info)

Anemia. *Placental hemorrhage. *Severe hemolytic disease. *Sepsis[7]. Pathophysiology[edit]. The exact pathologic mechanism for ...

https://en.wikipedia.org/wiki/Renal_Cortical_Necrosis

"What Is Hemolytic Anemia? - NHLBI, NIH". United States National Institutes of Health. 2011-04-01. Retrieved 2012-11-24.. ... The main consequence of hemolysis is hemolytic anemia, condition that involves the destruction of erythrocytes and their later ...

https://en.wikipedia.org/wiki/Hemolysin

talk , contribs)‎ (→‎Mechanical hemolytic anemia). *(diff , hist) . . m Wikipedia:Reference desk/Science‎; 02:56 . . (+358)‎ ... talk , contribs)‎ (→‎Mechanical hemolytic anemia). *(diff , hist) . . Wikipedia:Reference desk/Science‎; 17:19 . . (+314)‎ . . ...

https://en.wikipedia.org/wiki/Special:RecentChangesLinked/Wikipedia:Reference_desk/Archives/Science/2009_August_3

This variant causes a mild chronic hemolytic anemia.. *Hemoglobin E (α2βE2) - Another variant due to a variation in the β-chain ... This variant causes a mild chronic hemolytic anemia.. *Hemoglobin AS - A heterozygous form causing sickle cell trait with one ... Anemia has many different causes, although iron deficiency and its resultant iron deficiency anemia are the most common causes ... Anemias are classified by the size of red blood cells, the cells that contain hemoglobin in vertebrates. The anemia is called " ...

https://en.wikipedia.org/wiki/Hemoglobin_deficiency

"Undetectable Glycosolated Hemoglobin in Autoimmune Hemolytic Anemia" (PDF). repository.oai.yamaguchi-u.ac.jp. Retrieved 2009-08 ... In autoimmune hemolytic anemia, concentrations of hemoglobin A1 (HbA1) is undetectable. Administration of prednisolone (PSL) ... hemolytic anemia, or genetic differences in the hemoglobin molecule (hemoglobinopathy) such as sickle-cell disease and other ... Results can be unreliable in many circumstances, for example after blood loss, after surgery, blood transfusions, anemia, or ...

https://en.wikipedia.org/wiki/Hemoglobin_A1C

In 1956 Alving and colleagues showed that in some African Americans the antimalarial drug primaquine induces hemolytic anemia, ... Therefore, pyruvate kinase deficiency can cause hemolytic anemia. There is a significant correlation between severity of PK ... It has long been known that a kind of anemia, termed thalassemia, has a high frequency in some Mediterranean populations, ... In Gambians, it was estimated that AS heterozygotes have 90% protection against P. falciparum-associated severe anemia and ...

https://en.wikipedia.org/wiki/Genetic_Resistance_to_Malaria

"Hemolytic Anemia". Johns Hopkins Medicine Health Library. Retrieved 2019-04-09. "Hemolytic Disease of the Newborn (HDN) - ... causing the aforementioned haemolytic reaction in the foetus known as haemolytic disease of the newborn. This disease is ... The baby may have pale skin due to anaemia. The yellowing of the umbilical cord, skin and eyes, also known as jaundice, may ... Tachycardia, the increase in heart rate, is also a symptom of the haemolytic disease. In the case of pregnancy, when an RhD- ...

https://en.wikipedia.org/wiki/Rh_factor_testing

"Hemolytic Anemia". John Hopkins Medicine. Goodpasture Syndrome at eMedicine Graves Disease at eMedicine Descotes, Jacques; ... can also occur during the transmission of incompatible maternal antibodies to fetal red blood cells causing hemolytic anemia in ... An example of complement dependent type II hypersensitivity is an acute haemolytic transfusion reaction following transfusion ...

https://en.wikipedia.org/wiki/Type_II_hypersensitivity

"Hemolytic Anemia". University of Virginia Health System. Retrieved 2009-05-01. CS1 maint: discouraged parameter (link) Schaer ... Main symptoms that may appear in anemia. (See also Wikipedia:Anemia#Signs and symptoms). To discuss image, please see Template ... This is an effect of intravascular hemolysis, in which hemoglobin separates from red blood cells, a form of anemia. ... which is known as anemia. If the test shows higher levels than normal, it means they have hemoglobinemia.[citation needed] The ...

https://en.wikipedia.org/wiki/Hemoglobinemia

Tishler, M; Abramov, A (1983). "Phenazopyridine-induced hemolytic anemia in a patient with G6PD deficiency". Acta Haematol. 70 ... February 1982). "Acquired methemoglobinemia and hemolytic anemia after usual doses of phenazopyridine". Drug Intell Clin Pharm ... Galun E, Oren R, Glikson M, Friedlander M, Heyman A (November 1987). "Phenazopyridine-induced hemolytic anemia in G-6-PD ... Mercieca JE, Clarke MF, Phillips ME, Curtis JR (4 Sep 1982). "Acute hemolytic anaemia due to phenazopyridine hydrochloride in G ...

https://en.wikipedia.org/wiki/Phenazopyridine

... hemolytic anemia causes increased heme metabolism; exception: infants where gut flora has not developed). Serum: increased ... Commonly, diseases of the kidney, such as hemolytic uremic syndrome, can also lead to coloration. In jaundice secondary to ... Certain genetic diseases, such as sickle cell anemia, spherocytosis, thalassemia, pyruvate kinase deficiency, and glucose 6- ... and hemolytic disorders that include hereditary spherocytosis, glucose-6-phosphate dehydrogenase deficiency, pyruvate kinase ...

https://en.wikipedia.org/wiki/Jaundice

"Bilirubin and hemolytic anemia". eClinpath. Archived from the original on 2018-08-07. Retrieved 2019-05-05. Namita Roy- ... In jaundice owing to hemolysis (Prehepatic (or hemolytic) jaundice), the pathophysiology is that overproduction of bilirubin ...

https://en.wikipedia.org/wiki/Bilirubin_glucuronide

Brodsky RA (November 2015). "Complement in hemolytic anemia". Blood. 126 (22): 2459-65. doi:10.1182/blood-2015-06-640995. PMID ...

https://en.wikipedia.org/wiki/CD55_deficiency

A low Hx level is one of the diagnostic features of an intravascular hemolytic anemia. Hx has been implicated in cardiovascular ... "Bilirubin and hemolytic anemia". eClinpath. Retrieved 2019-05-08. Online Mendelian Inheritance in Man (OMIM): Orthosatic ... In past there have been reports showing that in patients with sickle cell disease, spherocytosis, autoimmune hemolytic anemia, ... and underlies the rationale for exogenous Hp and Hx as therapeutic proteins in hemolytic or hemorrhagic conditions. Hemopexin ...

https://en.wikipedia.org/wiki/Hemopexin

Autoimmune hemolytic anemia (AIHA, also called immune-mediated hemolytic anemia, or IMHA) and immune-mediated thrombocytopenia ... McDonald, Nancy (2013). "Immune Mediated Hemolytic Anemia". BichonHealth.org. Bichon Frise Club of America. Archived from the ... Hematologic causes of death were divided between autoimmune hemolytic anemia (AIHA) and immune-mediated thrombocytopenia (ITP ... In AIHA, the dog's immune system attacks its own red blood cells, leading to severe, life-threatening anemia. Symptoms include ...

https://en.wikipedia.org/wiki/Bichon_Frise

"Bilirubin and hemolytic anemia". eClinpath. Retrieved 2019-05-08. Schaer, D. J.; Buehler, P. W.; Alayash, A. I.; Belcher, J. D ... William C Mentzer; Jennifer S Tirnauer (eds.). "Diagnosis of hemolytic anemia in the adult". UpToDate. Archived from the ... "Hazard classification of chemicals inducing haemolytic anaemia: An EU regulatory perspective" (PDF). Regulatory Toxicology and ... However, during hyper-hemolytic conditions or with chronic hemolysis, haptoglobin is depleted so the remaining free hemoglobin ...

https://en.wikipedia.org/wiki/Intravascular_hemolysis

Autoimmune hemolytic anemia,[64] which is an autoimmune blood disorder.[65]. *Sebaceous adenitis[66][67][68] is an autoimmune ... Day, M.J (1999). "Antigen specificity in canine autoimmune haemolytic anaemia". Veterinary Immunology and Immunopathology. 69 ( ...

https://en.wikipedia.org/wiki/American_Akita

Acquired Autoimmune Hemolytic Anemia Allgood, JW; Chaplin, H Jr (1967). "Idiopathic acquired autoimmune hemolytic anemia. A ... "Type-specific cold auto-antibodies as a cause of acquired hemolytic anemia and hemolytic transfusion reactions: biologic test ... Berentsen, Sigbjørn; Sundic, Tatjana (2015-01-29). "Red Blood Cell Destruction in Autoimmune Hemolytic Anemia: Role of ... Lodi, Gianluca; Resca, Daniela; Reverberi, Roberto (2010-08-06). "Fatal cold agglutinin-induced haemolytic anaemia: a case ...

https://en.wikipedia.org/wiki/Cold_sensitive_antibodies

The cause was hemolytic anemia. ... "R.I.P. Syd Field, "guru of all screenwriters"". News. Retrieved 2020-01-02. "Syd Field ...

https://en.wikipedia.org/wiki/Syd_Field

Hemolytic anemia contributes to jaundice. A feature of leptospirosis is acute haemolytic anaemia and conjugated ...

https://en.wikipedia.org/wiki/Leptospirosis

It is sometimes prescribed for extreme cases of immune-mediated hemolytic anemia.[61] ...

https://en.wikipedia.org/wiki/Ciclosporin

He was born with hemolytic anemia. His older brother, Walter Jr., played college basketball for Texas-Rio Grande Valley and ...

https://en.wikipedia.org/wiki/Herbert_Jones_(basketball)

Yoo, D; Lessin, LS (1992). "Drug-associated 'bite cell' Hemolytic anemia". The American Journal of Medicine. 92 (3): 243-8. doi ... Patients may attempt to decrease exposure to hypoxia, which can then lead to hemolytic disorders. If one is not G6PD deficient ...

https://en.wikipedia.org/wiki/Degmacyte

A cause of hereditary hemolytic anemia". The New England Journal of Medicine. 286 (11): 557-61. doi:10.1056/NEJM197203162861101 ... Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. Model organisms have ... "A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia". Blood. 95 (7): ... "Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia". Blood. 75 (1): 271-3. doi:10.1182/blood.V75.1.271.271. PMID ...

https://en.wikipedia.org/wiki/GCLC

... hemolytic anemia List of hematologic conditions Paroxysmal cold hemoglobinuria Warm antibody autoimmune hemolytic anemia "Cold ... the number of symptoms and severity of symptoms may depend on how severe the anemia is. Signs and symptoms of hemolytic anemia ... In most cases, the diagnosis is based on evidence of hemolytic anemia (from symptoms and/or blood tests). A person may also be ... It is a form of autoimmune hemolytic anemia, specifically one in which antibodies bind red blood cells only at low body ...

https://en.wikipedia.org/wiki/Cold_agglutinin_disease

... in cases of DCT positive haemolytic anaemia). Platelet counts may be reduced, increased or normal. Haemoglobin levels are ... Blood transfusions and EPO administration are used to raise haemoglobin levels in cases with anaemia. Azacitidine is a drug ...

https://en.wikipedia.org/wiki/Chronic_myelomonocytic_leukemia

Hemolytic anemia resulting from the treatment of burns with copper compounds is infrequent. Chronic (long-term) effects of ...

https://en.wikipedia.org/wiki/Copper_toxicity

SEC23B Anemia, hemolytic, due to UMPH1 deficiency; 266120; NT5C3 Anemia, hemolytic, Rh-null, regulator type; 268150; RHAG ... SLC40A1 Hemolytic anemia due to adenylate kinase deficiency; 612631; AK1 Hemolytic anemia due to gamma-glutamylcysteine ... GCLC Hemolytic anemia due to glutathione synthetase deficiency; 231900; GSS Hemolytic anemia due to hexokinase deficiency; ... HK1 Hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency; 613470; GPI Hemolytic uremic syndrome, ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

Hemolytic anemia also is known to occur.[citation needed] Progressive Retinal Atrophy (PRA) is also present in the breed. The ...

https://en.wikipedia.org/wiki/Entlebucher_Mountain_Dog

Schneider, Arthur S.; William N. Valentine; Hattori M; H. L. Heins Jr (1965). "Hereditary Hemolytic Anemia with Triosephosphate ... It is a unique glycolytic enzymopathy that is characterized by chronic haemolytic anaemia, cardiomyopathy, susceptibility to ...

https://en.wikipedia.org/wiki/Triosephosphate_isomerase_deficiency

Other autoimmune diseases that have been treated with rituximab include autoimmune hemolytic anemia, pure red cell aplasia, ... Autoimmune Hemolytic Anemia, and Evans Syndrome" (PDF). Mayo Clinic Proceedings. 78: 1340-1346. doi:10.4065/78.11.1340. PMID ... chronic inflammatory demyelinating polyneuropathy and autoimmune anemias.[16] The most dangerous, although among the most rare ...

https://en.wikipedia.org/wiki/Rituximab

A 4-year-old boy with icteric (jaundiced) sclera which later proved to be a manifestation of hemolytic anemia due to G6PD ...

https://or.wikipedia.org/wiki/ଜଣ୍ଡିସ୍

非結合性膽紅素過高可能是因為溶血性貧血（英語：Hemolytic anemia）、血腫（英語：Hematoma）、像吉爾波特症候群

https://zh.wikipedia.org/zh-tw/黄疸

... chronic hemolytic anemia,[34] immunosuppression,[35] hemophilia B Leyden,[36] and thrombophlebitis and myocardial infarction.[ ...

https://en.wikipedia.org/wiki/TATA_box

This can occur in hemolytic anemia and idiopathic thrombocytopenic purpura. Eosinophilia. Main article: Eosinophilia ... Blood cell dysfunction - aplastic anemia. *Infectious diseases - viral (AIDS, SARS, West Nile encephalitis, hepatitis, herpes, ... Blood cell dysfunction - megaloblastic anemia, myelodysplasia, marrow failure, marrow replacement, acute leukemia ...

https://en.wikipedia.org/wiki/Immune_cell

... such as in sickle cell anemia, where there is a risk of massive hemolysis due to low oxygen tension or hemolytic crisis due to ...

https://en.m.wikipedia.org/wiki/Intravenous_regional_anesthesia

... haemolytic-uraemic syndrome, membranoproliferative glomerulonephritis) Factor D deficiency (Neisserial infections) Properdin ... Blau syndrome Chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anemia (Majeed syndrome) DIRA ( ...

https://en.wikipedia.org/wiki/Primary_immunodeficiency

haemolytic jaundice - caused by destruction of red blood cells. This causes increased bilirubin formation and anaemia ... Other causes of jaundice are pernicious anaemia and diseases affecting the liver such as typhoid, malaria, yellow fever and ...

https://simple.wikipedia.org/wiki/Jaundice

Risk factors for pigment stones include hemolytic anemias (such as from sickle-cell disease and hereditary spherocytosis), ... "Studies on the Pathogenesis of Pigment Gallstones in Hemolytic Anemia". Journal of Clinical Investigation. 65 (6): 1301-8. doi: ...

https://en.m.wikipedia.org/wiki/Gallstones

Hemolytic anemia வில் குருதிச் சிவப்பணுக்கள் அழிவடைவதால், மஞ்சள் காமாலை நோய் ஏற்படும். மேலும் எலும்புகளில் அமைப்பு மாற்றம், ... Macrocytic anemia (MCV,100) Normocytic anemia (80,MCV,100) Microcytic anemia (MCV,80) ... merriam-webster dictionary --, anemia Retrieved on May 25, 2009 *↑ eMedicineHealth , anemia article Author: Saimak T. Nabili, ... World Health Organization (2008). Worldwide prevalence of anaemia 1993-2005. Geneva: World Health Organization. ISBN ...

https://ta.wikipedia.org/wiki/குருதிச்சோகை

Autoimmune hemolytic anemia. *Immune thrombocytopenic purpura. *Bullous pemphigoid. *Pemphigus vulgaris. *Rheumatic fever ...

https://en.wikipedia.org/wiki/Antibody-dependent_cellular_cytotoxicity

Autoimmune hemolytic anemia. *Immune thrombocytopenic purpura. *Bullous pemphigoid. *Pemphigus vulgaris. *Rheumatic fever ...

https://en.wikipedia.org/wiki/Food_allergy

Autoimmune hemolytic anemia. *Immune thrombocytopenic purpura. *Bullous pemphigoid. *Pemphigus vulgaris. *Rheumatic fever ...

https://en.wikipedia.org/wiki/Type_IV_delayed_hypersensitivity_reaction

... hemolytic anemia, acute kidney injury, liver toxicity, and blindness.[27] In people with atrial fibrillation, conduction ... cause unpredictable serious and life-threatening blood and cardiovascular reactions including low platelet count and hemolytic- ...

https://en.wikipedia.org/wiki/Quinine

... and microangiopathic hemolytic anemia. ...

https://en.wikipedia.org/wiki/Hypertensive_emergency

... haemolytic anaemia, leucopenia, thrombocytopenia, and coagulation disorders. Also reported diarrhoea (including antibiotic- ...

https://en.wikipedia.org/wiki/Benzylpenicillin

It can have several causes and can result in hemolytic anemia.. *The malaria parasite spends part of its life-cycle in red ... Eryptosis is increased in a wide variety of diseases including sepsis, haemolytic uremic syndrome, malaria, sickle cell anemia ... Iron deficiency anemia is the most common anemia; it occurs when the dietary intake or absorption of iron is insufficient, and ... Pernicious anemia is an autoimmune disease wherein the body lacks intrinsic factor, required to absorb vitamin B12 from food. ...

https://en.m.wikipedia.org/wiki/Red_blood_cells

Haematologic: Autoimmune haemolytic anaemia, Idiopathic thrombocytopenic purpura. *Neurological: Multiple sclerosis, Myasthenia ... In addition to chronic and/or recurrent infections many autoimmune diseases including arthritis, autoimmune hemolytic anemia, ... The idea of molecular mimicry arose in the context of Rheumatic Fever, which follows infection with Group A beta-haemolytic ...

https://en.wikipedia.org/wiki/Autoimmune

Autoimmune hemolytic anemia · Idiopathic thrombocytopenic purpura · Bullous pemphigoid · Pemphigus vulgaris · Rheumatic fever · ...

https://kn.wikipedia.org/wiki/ಅಲರ್ಜಿ

K. Santucci, B.Shah (2000). Association of naphthalene with acute hemolytic anemia. Acad Emerg Med. 7 (1): 42-47. ...

https://sl.m.wikipedia.org/wiki/Naftalen

Hemolytic anemia, in which red blood cells are destroyed and removed from the blood, also develops. Chills, sweats, and ... When people do develop symptoms, the most common are fever and hemolytic anemia, symptoms that are similar to those of malaria. ... In bovine species, the organism causes hemolytic anemia, so an infected animal shows pale mucous membranes initially. As the ... and cause hemolytic anemia, quite similar to malaria. Unlike the Plasmodium parasites that cause malaria, Babesia species lack ...

https://en.wikipedia.org/wiki/Babesiosis

... as mice lacking peroxiredoxin 1 or 2 have shortened lifespan and suffer from hemolytic anaemia, while plants use peroxiredoxins ...

https://en.wikipedia.org/wiki/Free_radical_scavenger

... is known to cause hemolytic anemia in people who have the genetic disease glucose-6-phosphate dehydrogenase deficiency ...

https://en.wikipedia.org/wiki/Acetylsalicylic_acid

Micro-: Iron deficiency anemia (Plummer-Vinson syndrome). Macro-: Megaloblastic anemia (Pernicious anemia) ... Hemolytic. (mostly Normo-). Hereditary. enzymopathy: G6PD · glycolysis (PK, TI, HK) hemoglobinopathy: Thalassemia (alpha, beta ... Cooley's anemia)। নবজাতক যেসব শিশুর এই সমস্যা থাকে তারা জন্মের সময় বেশ স্বাস্থ্যবান থাকে। তবে জন্মের প্রথম দুই বছরের মধ্যেই এর ...

https://bn.wikipedia.org/wiki/থ্যালাসেমিয়া

Antibodies directed against red blood cell surface antigens in immune mediated hemolytic anemia are detected with the Coombs ... Urbaniak S, Greiss M (2000). "RhD haemolytic disease of the fetus and the newborn". Blood Rev. 14 (1): 44-61. doi:10.1054/blre. ... at risk for hemolytic disease of the newborn.[66] ... "Chapter 4: Hemolytic disease of the newborn". Blood Groups and ...

https://en.wikipedia.org/wiki/Antibody

... haemolytic anemia, and a very rapid age-dependent decline in female fertility.[9] ...

https://en.wikipedia.org/wiki/Superoxide

... hemolytic anemia），這取決於用量的多少和病情的嚴重性。[72] 不建議登革熱患者服用該藥，

https://zh.wikipedia.org/zh-hant/阿斯匹林

Hemolytic anemia is a type of anemia that happens when red blood cells break down faster than the body can make them. ... Anemia hemolítica. What Is Hemolytic Anemia?. Anemia is when the number of red blood cells in the body gets too low. Red blood ... Symptoms of hemolytic anemia may be mild and slowly get worse, or become severe quickly. Someone with hemolytic anemia might:. ... How Is Hemolytic Anemia Treated?. Treatment for hemolytic anemia depends on the cause. A hematologist (a doctor who treats ...

https://www.kidshealth.org/Nemours/en/parents/anemia-hemolytic.html

Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body ... Outcome depends on the type and cause of hemolytic anemia. Severe anemia can make heart disease, lung disease, or ... Hemolytic anemia occurs when the bone marrow isnt making enough red cells to replace the ones that are being destroyed. ... Hemolytic anemias: red blood cell membrane and metabolic defects. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ...

https://medlineplus.gov/ency/article/000571.htm

Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to the ... Immune hemolytic anemia occurs when antibodies form against the bodys own red blood cells and destroy them. This happens ... Michel M, Jäger U. Autoimmune hemolytic anemia. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic ... In hemolytic anemia, red blood cells in the blood are destroyed earlier than normal. ...

https://medlineplus.gov/ency/article/000576.htm

A hemolytic anemia will develop if bone marrow activity cannot compensate for the erythrocyte loss. ... encoded search term (Hemolytic Anemia) and Hemolytic Anemia What to Read Next on Medscape. Medscape Consult. ... Arbach O, Funck R, Seibt F, Salama A. Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated ... Go to Anemia, Iron Deficiency Anemia, and Chronic Anemia for complete information on these topics. ...

https://emedicine.medscape.com/article/201066-differential

Autoimmune hemolytic anemia, or AIHA, is an immune condition where the immune system destroys red blood cells. It can lead to a ... Autoimmune hemolytic anemia (AIHA), or immune hemolytic anemia, happens when the immune system does not work properly. It ... All about autoimmune hemolytic anemia. Medically reviewed by Alana Biggers, M.D., MPH on. December 14, 2018. - Written by ... Hemolytic anemia develops when there are not enough red blood cells because the body destroys them sooner than it should. Red ...

https://www.medicalnewstoday.com/articles/312508

if you have a disease thats causing your anemia, your doctor will treat. if a medicine is the cause, youll likely have to ... "How is Hemolytic Anemia Diagnosed?" "Types of Hemolytic Anemia," "What Are the Signs and Symptoms of Hemolytic Anemia?" "What ... "How is Hemolytic Anemia Diagnosed?" "Types of Hemolytic Anemia," "What Are the Signs and Symptoms of Hemolytic Anemia?" "What ... How is acquired autoimmune hemolytic anemia (AIHA) treated?. ANSWER If you have a disease thats causing your anemia, your ...

https://www.webmd.com/a-to-z-guides/qa/how-is-acquired-autoimmune-hemolytic-anemia-aiha-treated

Hemolytic anemia definition, an anemic condition characterized by the destruction of red blood cells: seen in some drug ... hemolytic anemia in Medicine Expand. hemolytic anemia n. Anemia resulting from the abnormal destruction of of red blood cells, ... Anemia resulting from the lysis of red blood cells, as in response to certain toxic or infectious agents and in certain ...

http://www.dictionary.com/browse/hemolytic-anemia

G. Garratty, "Drug-induced immune hemolytic anemia," Hematology/the Education Program of the American Society of Hematology. ... G. Garratty, "Immune hemolytic anemia associated with drug therapy," Blood Reviews, vol. 24, no. 4-5, pp. 143-150, 2010. View ... Drug-induced autoimmune hemolytic anemia is a rare condition. We report the case of a 32-year-old white female who presented to ... The patient had evidence of hemolytic anemia with a hemoglobin of 6.7 g/dL which dropped to 5 g/dL on day 2, the direct Coombs ...

https://www.hindawi.com/journals/criid/2014/201015/

... hemolytic anemia occurs. Learn the myriad causes of hemolytic anemia, common symptoms, and treatments to address this condition ... How is hemolytic anemia treated?. Treatment options for hemolytic anemia differ depending on the reason for anemia, severity of ... Hemolytic anemia can be extrinsic or intrinsic.. Extrinsic hemolytic. Extrinsic hemolytic anemia develops by several methods, ... Causes of hemolytic anemia. Its possible that a doctor may not be able to pinpoint the source of hemolytic anemia. However, ...

https://www.healthline.com/health/hemolytic-anemia

Symptomatic Haemolytic Anaemia. Br Med J 1968; 2 doi: https://doi.org/10.1136/bmj.2.5601.354-a (Published 11 May 1968) Cite ...

http://www.bmj.com/content/2/5601/354.2

... (IMHA) or Autoimmune hemolytic anemia (AIHA) In hemolytic anemia, a loss of red blood cells ( ... Immune mediated hemolytic anemia in Giant Schnauzer Question: I have a very sick giant schnauzer with hemolytic anemia. It ... Immune mediated hemolytic anemia (also known as auto-immune hemolytic anemia) can occur as a primary problem -- no discernible ... So the short answer is that immune mediated hemolytic anemia is one particular cause of hemolytic anemia but there are other ...

https://www.vetinfo.com/dimhanemia.html

The hemolytic anemias are a group of disorders in which the red blood cells are destroyed faster than the bone marrow can make ... Hemolytic Anemia in Children. What is hemolytic anemia in children?. Hemolytic anemia is a group of disorders in which the red ... What causes hemolytic anemia in a child?. Hemolytic anemia has 2 types of causes:. * Intrinsic. This is when the destruction of ... Key points about hemolytic anemia in children. * Hemolytic anemias are a group of conditions in which red blood cells are ...

https://www.nationwidechildrens.org/conditions/health-library/hemolytic-anemia-in-children

... Article Translations: (Spanish). What Is Hemolytic Anemia?. Anemia is when the number of red blood cells in ... Symptoms of hemolytic anemia may be mild and slowly get worse, or become severe quickly. Someone with hemolytic anemia might:. ... How Is Hemolytic Anemia Treated?. Treatment for hemolytic anemia depends on the cause. A hematologist (a doctor who treats ... Hemolytic anemias that are not inherited include:. * autoimmune hemolytic anemia: This happens when the infection-fighting ...

https://www.childrensmn.org/educationmaterials/parents/article/18374/hemolytic-anemia/

Ask questions and get answers about Autoimmune Hemolytic Anemia. Our support group helps people share their own experience. 6 ... Home › Q & A › Support Groups › Autoimmune Hemolytic Anemia. Join the Autoimmune Hemolytic Anemia group to help and get ... Autoimmune Hemolytic Anemia Support Group. Related terms: Drug-Induced Immune Hemolytic Anemia ... Hemolytic Anemia. Related Drug Support Groups. prednisone, Deltasone, Sterapred, Liquid Pred, Sterapred DS, Meticorten, Orasone ...

https://www.drugs.com/answers/support-group/autoimmune-hemolytic-anemia/

C. H. Packman, "Hemolytic anemia due to warm autoantibodies," Blood Reviews, vol. 22, no. 1, pp. 17-31, 2008. View at Publisher ... L. D. Petz, "Treatment of autoimmune hemolytic anemias," Current Opinion in Hematology, vol. 8, no. 6, pp. 411-416, 2001. View ... B. C. Gehrs and R. C. Friedberg, "Autoimmune hemolytic anemia," American Journal of Hematology, vol. 69, no. 4, pp. 258-271, ... K. E. King and P. M. Ness, "Treatment of autoimmune hemolytic anemia," Seminars in Hematology, vol. 42, no. 3, pp. 131-136, ...

https://www.hindawi.com/journals/jir/2013/561852/ref/

Non-spherocytic Haemolytic Anaemia. Br Med J 1961; 1 doi: https://doi.org/10.1136/bmj.1.5220.210-a (Published 21 January 1961) ...

http://www.bmj.com/content/1/5220/210.2

Microangiopathic hemolytic anemia occurs when the red cell membrane is damaged in circulation, leading to intravascular ... Disorders of red blood cell enzymes, membranes, and hemoglobin cause hereditary hemolytic anemias. Glucose-6-phosphate ... Common acquired causes of hemolytic anemia are autoimmunity, microangiopathy, and infection. Immune-mediated hemolysis, caused ... Sickle cell anemia and thalassemia are hemoglobinopathies characterized by chronic hemolysis. ...

https://www.aafp.org/afp/2004/0601/p2599.html

Video Tag: Congenital Hemolytic Anemia. SAGES Webinar : Preparing for the ABSITE-December 2016. ... congenital hemolytic anemia, constipation, continence, COPD, corticosteroids, Crohns colitis, Crohns disease, CT scan, CXR, ... sideroblastic anemia, sigmoid colectomy, sigmoid colon resection, sigmoid diverticulitis, sigmoidoscopy, skin, small bowel, ... microcytic hypochromic anemia, midline episiotomy, morphine-neostigmine Nardi test, mortality, mucin, mucosa, mucosal ...

https://www.sages.org/video-tag/congenital-hemolytic-anemia/

Low-grade hemolytic anemia occurs in 70% of prosthetic heart valve recipients, and severe hemolytic anemia occurs in 3%.[4] ... In cold hemolytic anemia there is advantage in transfusing warmed blood.. *In severe immune-related hemolytic anemia, steroid ... Similarly, poisoning by arsine or stibine also causes hemolytic anemia.. *Runners can suffer hemolytic anemia due to " ... Main articles: Congenital hemolytic anemia and Acquired hemolytic anemia. They may be classified according to the means of ...

https://en.m.wikipedia.org/wiki/Hemolytic_anemia

... , Autoimmune Hemolysis, Immune Hemolytic Anemia, AIHA, Warm Hemolysis, Cold Hemolysis, Cold ... Warm Autoimmune Hemolytic Anemia, Cold Autoimmune Hemolytic Anemia. ... immune hemolytic anemia, anemias hemolytic immune, anemia hemolytic immune, immune hemolytic anemias, Immune Hemolytic Anemia, ... anemia hemolytic autoimmune, hemolytic autoimmune anemia, anemia autoimmune hemolytic, autoimmune hemolytic anemia, anaemia ...

https://fpnotebook.com/legacy/HemeOnc/Hemolysis/AtmnHmlytcAnm.htm

Microangiopathic hemolytic anemia definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and ...

https://www.dictionary.com/browse/microangiopathic-hemolytic-anemia

The major diagnostic problems encountered with hemolytic disorders are when the known causes for hemolysis have been excluded ... Drugs & Diseases , Hematology , Anemia Q&A When are major challenges in the diagnosis of hemolytic anemias?. Updated: Oct 08, ... When are major challenges in the diagnosis of hemolytic anemias?) and When are major challenges in the diagnosis of hemolytic ... Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation. Blood Adv. 2018 ...

https://www.medscape.com/answers/198475-155092/780334-overview

Drug-induced immune hemolytic anemia is a rare blood disorder. It occurs when medication you take leads your immune system to ... What Is Drug-Induced Immune Hemolytic Anemia?. Drug-induced immune hemolytic anemia (DIIHA) is an extremely rare blood disorder ... Drug-Induced Immune Hemolytic Anemia. Medically reviewed by Steve Kim, MD on January 11, 2016. - Written by Cindie Slightham ... Outlook for Drug-Induced Immune Hemolytic Anemia. Your outlook is good as long as the medication is stopped quickly. Your body ...

https://www.healthline.com/health/drug-induced-immune-hemolytic-anemia

Donath-Landsteiner hemolytic anemia (DLHA) and cold agglutinin disease. DLHA is an intravascular hemolytic anemia caused by a ... Two forms of cold antibody autoimmune hemolytic anemias are generally recognized: ... encoded search term (Donath-Landsteiner Hemolytic Anemia) and Donath-Landsteiner Hemolytic Anemia What to Read Next on Medscape ... Two forms of cold antibody autoimmune hemolytic anemias are generally recognized: Donath-Landsteiner hemolytic anemia (DLHA) ...

https://emedicine.medscape.com/article/955176-overview

The methemoglobinemia and hemolytic anemia observed in experimental animals given aniline has been shown to be mediated by its ... Hemolytic Anemia Hemolytic Activity Erythrocyte Suspension Aniline Derivative Erythrocyte Membrane Protein These keywords were ... The methemoglobinemia and hemolytic anemia observed in experimental animals given aniline has been shown to be mediated by its ... 4-Dichlorophenylhydroxylamine in Propanil-Induced Hemolytic Anemia. In: Witmer C.M., Snyder R.R., Jollow D.J., Kalf G.F., ...

https://link.springer.com/chapter/10.1007%2F978-1-4684-5877-0_44

Experimental onion-induced hemolytic anemia in dogs.. Harvey JW, Rackear D.. Abstract. Within one day following a single oral ... As with Heinz body-containing cells, the percentages of eccentrocytes present declined as anemia developed. The packed cell ...

https://www.ncbi.nlm.nih.gov/pubmed/4035943

Hand selected websites about Hemolytic Anemia. Free. Healthcare information from the top websites about physical and mental ... Top / Health / Conditions and Illness / Blood Disorders / Anemia / Hemolytic All Reference Health: Hemolytic Anemia Reveals ... Answers.com: Hemolytic Anemia Offers a guide to the disorders symptoms, causes, diagnoses and therapies. ... Wrong Diagnosis: Hemolytic Anemia Locate statistics, symptoms, types, causes, prognoses and a glossary of terms. ...

https://botw.org/top/Health/Conditions_and_Illness/Blood_Disorders/Anemia/Hemolytic/

... Hemolytic anemiaClassification & external resources ICD-10 D55.-D59. ICD-9 282, 283, 773 DiseasesDB 5534 ... Iron deficiency anemia, Plummer-Vinson syndrome, Megaloblastic anemia (Pernicious anemia). hereditary hemolytic anemia: G6PD ... acquired hemolytic anemia: Autoimmune (Warm), HUS, MAHA, PNH, PCH aplastic anemia: Acquired PRCA, Diamond-Blackfan anemia, ... Immune mediated hemolytic anaemia (direct Coombs test is positive) *Autoimmune hemolytic anemia *Warm antibody autoimmune ...

https://www.bionity.com/en/encyclopedia/Hemolytic_anemia.html

... fully recovered from an Immune Mediated Hemolytic Anemia (IMHA) or Autoimmune Hemolytic Anemia (AIHA). Also cases of congestive ... Dog Recovers From Auto Immune Hemolytic Anaemia (AIHA) "My dog Arnie had been given up on by the vet. He had acute anemia ... Maltese saved from Auto Immune Hemolytic Anemia (AIHA). On March 26, 2007 my maltese, Mya, woke up not feeling well at all. She ... It was at this point the doctor requested labs be drawn to rule out Immune-Mediated Hemolytic Anemia (IMHA). While he did not ...

https://www.shirleys-wellness-cafe.com/Testimonials/AmailBag2

Learn more about Hemolytic Anemia symptoms, diagnosis, and treatments from experts at Boston Childrens, ranked best Childrens ... Learn more about hemolytic anemia, including types of hemolytic anemias and hemolytic anemia treatments, on the Dana-Farber/ ... Hemolytic anemias can be divided into two categories.. *Inherited (or intrinsic) hemolytic anemia is caused by a defect in the ... Hemolytic Anemia. Hemolytic anemia is a type of blood disorder that occurs when the body has fewer red blood cells than normal ...

http://www.childrenshospital.org/conditions-and-treatments/conditions/h/hemolytic-anemia

Autoimmune hemolytic anemia (AIHA), or immune hemolytic anemia, happens when the immune system does not work properly. (medicalnewstoday.com)
How is acquired autoimmune hemolytic anemia (AIHA) treated? (webmd.com)
This page includes 3 cases of dogs who fully recovered from an Immune Mediated Hemolytic Anemia (IMHA) or Autoimmune Hemolytic Anemia (AIHA). (shirleys-wellness-cafe.com)
Autoimmune hemolytic anemia (AIHA) is a relatively uncommon disorder caused by autoantibodies directed against self red blood cells. (nih.gov)
AIHA may develop gradually, or have a fulminant onset with life-threatening anemia. (nih.gov)
Autoimmune hemolytic anemia (AIHA) is characterized by shortened red cell survival that is caused by autoantibodies directed against RBCs, with or without the participation of complement on the red cell membrane. (unboundmedicine.com)
Through a series of case studies, the speakers will discuss the diagnosis of warm autoimmune hemolytic anemia (AIHA), including the required clinical information, and the essential laboratory tests necessary to help identify the type of autoantibody. (aabb.org)
Despite continued aggressive treatment for presumed autoimmune hemolytic anemia (AIHA), the patient developed progressive hepatic, renal, and respiratory failure with marked acidosis requiring multiple transfusions of platelets and fresh frozen plasma, hemodialysis, and endotracheal intubation. (aacc.org)
Immune mediated hemolytic anemia (IMHA), also known as auto-immune mediated hemolytic anemia (AIHA), is a disease in which the body's immune system, which is designed to attack and kill germs, attacks and kills the body's own red blood cells. (petplace.com)
Autoimmune Hemolytic Anemia (AIHA) is characterized by antibody-induced erythrocyte destruction. (oncologynurseadvisor.com)
If AIHA is secondary to an underlying disease or drug, the signs and symptoms may be more related to the primary condition than to the anemia itself. (oncologynurseadvisor.com)
AIHA could be confused with a hemolytic crisis in patients with G-6-PD deficiency, pyruvate kinase (PK) deficiency, or another more rare congenital enzymopathy. (oncologynurseadvisor.com)
Hemolytic anemia may be due to other immune mediated mechanisms such as with ABO incompatibility (in the neonate) or with transfusion reactions but these conditions are not likely to be confused with AIHA. (oncologynurseadvisor.com)
2. Autoimmune hemolytic anemia (AIHA), is the result of antibody-mediated or complement-targeted red blood cell destruction. (renalandurologynews.com)
BALTIMORE-The B-cell directed monoclonal antibody rituximab (Rituxan) can produce durable complete remissions without the need for maintenance therapy in patients with cold agglutinin autoimmune hemolytic anemia (AIHA) and might also represent a treatment option in warm agglutinin AIHA, according to Edward Lee, MD. Dr. Lee is director of hematology and medical oncology at Sinai Hospital in Baltimore, and Director of the Bone Marrow Transplantation Program. (cancernetwork.com)
Autoimmune hemolytic anemia (AIHA), also called immune-mediated hemolytic anemia (IMHA), is a common, often manageable but potentially fatal condition in domestic dogs. (petwave.com)
Autoimmune hemolytic anaemia (AIHA) is a type of hemolytic anaemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction (hemolysis). (ndtv.com)
In autoimmune hemolytic anemia (AIHA), also called immune-mediated hemolytic anemia (IMHA) or idiopathic non-regenerative immune-mediated hemolytic anemia, the dog's immune system sees the red blood cells as foreign bodies and sends antibodies to attack the RBCs. (justusdogs.com.au)
Drugs That Can Cause Warm Antibody Hemolytic Anemia ) stimulate production of autoantibodies against Rh antigens (alpha- methyldopa -type of AIHA). (merckmanuals.com)

Hemolysis presents as acute or chronic anemia, reticulocytosis, or jaundice. (aafp.org)
Microangiopathic hemolytic anemia occurs when the red cell membrane is damaged in circulation, leading to intravascular hemolysis and the appearance of schistocytes. (aafp.org)
Sickle cell anemia and thalassemia are hemoglobinopathies characterized by chronic hemolysis. (aafp.org)
While hemolysis can be a lifelong asymptomatic condition, it most often presents as anemia when erythrocytosis cannot match the pace of red cell destruction. (aafp.org)
Anemia most often is discovered through laboratory tests, but the history and physical examination can provide important clues about the presence of hemolysis and its underlying cause. (aafp.org)
Along with anemia, a characteristic laboratory feature of hemolysis is reticulocytosis, the normal response of the bone marrow to the peripheral loss of red blood cells. (aafp.org)
The anemia of hemolysis usually is normocytic, although a marked reticulocytosis can lead to an elevated measurement of mean corpuscular volume, because the average mean corpuscular volume of a reticulocyte is 150 fL. (aafp.org)
Hemolytic anemia is a form of anemia due to hemolysis , the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular, but usually in the spleen ). (wikipedia.org)
Runners can suffer hemolytic anemia due to " footstrike hemolysis ", owing to the destruction of red blood cells in feet at foot impact. (wikipedia.org)
For all patients, hemolysis and worsening anemia were described after parasite clearance, 8-32 days after completion of artesunate therapy. (cdc.gov)
The patient's own antibodies are directed against antigens on their own red blood cells resulting in hemolysis and anemia. (oncologynurseadvisor.com)
Confirm that the anemia is due to hemolysis. (renalandurologynews.com)
Avoid empiric red blood cell and platelet transfusion unless the etiology of hemolysis is definitively known, or if life-threatening bleeding or anemia is present. (renalandurologynews.com)
Available at: http://www.merckmanuals.com/professional/hematology-and-oncology/anemias-caused-by-hemolysis/autoimmune-hemolytic-anemia. (epnet.com)
With warm antibody hemolytic anemia the hemolysis occurs mainly in the spleen. (nethealthbook.com)
In this patient's case, 1 even if she was experiencing autoimmune hemolysis, the reticulocyte count was inappropriately low to fully explain her degree of anemia (hemoglobin, 9.6 g/dL after transfusion of 4 units of packed red blood cells). (jaoa.org)
In warm antibody hemolytic anemia, hemolysis occurs primarily in the spleen and is not due to direct lysis of RBCs. (merckmanuals.com)
The PPVs were comparable in the three main categories of overall hemolysis, and congenital and acquired hemolytic anemia. (dovepress.com)

Microangiopathic hemolytic anemia (MAHA) is a microangiopathic subgroup of hemolytic anemia (loss of red blood cells through destruction) caused by factors in the small blood vessels. (wikipedia.org)
Microangiopathic hemolytic anemia is also seen in cancer. (wikipedia.org)
Microangiopathic hemolytic anemia may be suspected based on routine medical laboratory tests such as a CBC (complete blood cell count). (wikipedia.org)
Microangiopathic hemolytic anemia results in isolated increase in serum bilirubin levels. (wikipedia.org)
Other types include Microangiopathic Hemolytic Anemia, Nonspherocytic Hemolytic Anemia, Toxic Hemolytic Anemia (due to toxic agents, including drugs, bacterial lysins, and snake venoms) and Hemolytic Anemia of Newborn. (diagnose-me.com)
These are immune hemolytic anemia, microangiopathic hemolytic anemia, and by direct destruction of the red blood cell by the pathogen. (oncologynurseadvisor.com)
Microangiopathic hemolytic anemia (MAHA) is characterized by mechanical destruction of red blood cells. (oncologynurseadvisor.com)
Twelve months later while in complete clinical remission, pulmonary hypertension and microangiopathic hemolytic anemia were recognized, progressed, and ended in his demise 6 months later. (nih.gov)
Pulmonary veno-occlusive disease may occur in association with microangiopathic hemolytic anemia and cancer chemotherapy. (nih.gov)

Drug-induced immune hemolytic anemia (DIIHA) is an extremely rare blood disorder. (healthline.com)
What Are the Symptoms of Drug-Induced Immune Hemolytic Anemia? (healthline.com)
Drug-induced immune hemolytic anemia is a blood disorder that occurs when a medicine triggers the body's defense (immune) system to attack its own red blood cells. (limamemorial.org)

Symptoms of hemolytic anemia are similar to other forms of anemia ( fatigue and shortness of breath ), but in addition, the breakdown of red cells leads to jaundice and increases the risk of particular long-term complications, such as gallstones and pulmonary hypertension . (wikipedia.org)
Symptoms of hereditary spherocytic hemolytic anemia may include excessive tiredness and a moderate persistent yellow appearance to the skin (jaundice). (rarediseases.org)
Usually people with hereditary spherocytic hemolytic anemia have a family history of anemia, jaundice, or spleen enlargement (splenomegaly). (rarediseases.org)
Additional symptoms and findings may include irritability, bizarre behavior, absence of menstrual cycles in affected females (amenorrhea), gastrointestinal complaints, low levels of circulating red blood cells (anemia), enlargement of the spleen (splenomegaly), and/or persistent yellowing of the skin, mucuous membranes, and whites of the eyes (jaundice). (rarediseases.org)
Symptomatic hemolytic anemia may be defined as a hemolytic syndrome often indistinguishable by hematological methods from the well-known picture of familial hemolytic jaundice, but showing a definite etiological relationship to such underlying diseases as neoplasm (teratoma, sarcoma), leukemia, and Hodgkin's disease. (annals.org)
The absence of jaundice and/or hemoglobinuria may suggest "warm" or IgG complement mediated immune hemolytic disease. (oncologynurseadvisor.com)
Immune-mediated hemolytic anemia ( IMHA ) is the condition where the body's immune system attacks and removes its own red blood cells, thus leading to severe anemia, an unhealthy yellow coloring of the tissues called jaundice or icterus as well as an assortment of life-threatening complications. (veterinarypartner.com)
The infant patient we reported was the first child of a non-consanguineous married Chinese woman, with no family history of jaundice or anemia. (lww.com)
Symptoms of Auto-immune Hemolytic Anemia are jaundice, fainting, pale gums, lips and eye margins, dark tea colored urine, lethargy and rapid heartbeats. (dogtime.com)
mild anemia and jaundice 2. (scribd.com)
At the final episode, she presented with haemolytic anaemia with fatigue, jaundice and loss of appetite. (prohealth.com)

An enlarged spleen also raises a question of hemolytic anemia . (diagnose-me.com)

It was diagnosed as Auto Immune Hemolytic Anemia . (ndtv.com)
OBJECTIVE: To present an unusual case of recurrent auto-immune hemolytic anemia and the laparoscopic approach to identify and remove multiple accessory spleens. (sages.org)
Auto-immune Hemolytic Anemia is a life threatening disease where the body attacks its own red blood cells. (dogtime.com)
If Auto-immune Hemolytic Anemia is left untreated it will generally result in death. (dogtime.com)

HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia . (nih.gov)
Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency . (nih.gov)
Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia . (nih.gov)
Hereditary nonspherocytic hemolytic anemia and hexokinase deficiency . (nih.gov)
Hereditary nonspherocytic hemolytic anemia caused by a deficiency in erythrocytic hexokinase associated with glycogenosis of muscles]. (nih.gov)
Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic fragility associated with erythrocyte membrane defects, multiple intracellular enzyme deficiencies or other defects, or unstable hemoglobins. (diagnose-me.com)
Pyruvate kinase (PK) deficiency is the most common cause of hereditary nonspherocytic hemolytic anemia. (semanticscholar.org)
Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA). (semanticscholar.org)
Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia. (semanticscholar.org)
Metabolic abnormalities of erythrocytes from patients with congenital nonspherocytic hemolytic anemia. (semanticscholar.org)

Cold antibody hemolytic anemia (CAHA) is a rare autoimmune disorder characterized by the premature destruction of red blood cells (rbcs) by the body's natural defenses against invading organisms (antibodies). (rarediseases.org)
As their names imply, cold antibody hemolytic anemia occurs at temperatures of approximately 0 to 10 degrees centigrade, while warm antibody hemolytic anemia (WAHA) occurs at temperatures of 37 degrees centigrade or higher. (rarediseases.org)
Cold antibody hemolytic anemia may also occur as a secondary disorder in association with a number of different underlying disorders such as certain infectious diseases (e.g., mycoplasma infection, mumps, cytomegalovirus, infectious mononucleosis), immunoproliferative diseases (e.g., non-Hodgkin's lymphoma, chronic lymphocytic leukemia), or connective tissue disorders (e.g., systemic lupus erythematosus). (rarediseases.org)
The blood of patients with cold antibody hemolytic anemia, when exposed to cold temperatures, behaves in ways that are quite different from the blood of healthy people. (rarediseases.org)
Although cold antibody hemolytic anemia is known to be an autoimmune disorder, neither its exact underlying cause nor the process by which the disorder becomes apparent is fully understood. (rarediseases.org)
Cold antibody hemolytic anemia most commonly affects older people. (rarediseases.org)
Symptoms of the following disorders can be similar to those of Cold Antibody Hemolytic Anemia. (rarediseases.org)
The one type destroys red blood cells at temperatures above 37 degrees C (warm antibody hemolytic anemia). (nethealthbook.com)
Warm antibody hemolytic anemia is more common in women and is often associated with lupus, chronic lymphatic leukemia or lymphoma. (nethealthbook.com)
However, certain drugs can also induce warm antibody hemolytic anemia. (nethealthbook.com)
There is a long list of unstable haptens that can cause warm antibody hemolytic anemia with well known names: hydrochlorothiazide (diuretic for high blood pressure), diclofenac (for arthritis), isoniacide (for tuberculosis), doxepin (an antidepressant) and many more. (nethealthbook.com)
Autoimmune hemolytic anemia is caused by autoantibodies that react with RBCs at temperatures ≥ 37 ° C (warm antibody hemolytic anemia) or 37 ° C (cold agglutinin disease). (merckmanuals.com)
Most of the autoantibodies in warm antibody hemolytic anemia are IgG. (merckmanuals.com)

In diseases such as hemolytic uremic syndrome, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and malignant hypertension, the endothelial layer of small vessels is damaged with resulting fibrin deposition and platelet aggregation. (wikipedia.org)
MAHA is caused by thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), disseminated intravascular coagulation (DIC), or shear force created by extremely turbulent blood flow. (oncologynurseadvisor.com)
Thrombotic thrombocytopenic purpura (TTP, idiopathic or secondary), hemolytic uremic syndrome (HUS, typical or atypical). (renalandurologynews.com)
Other such conditions are extremely high blood pressure (malignant hypertension), thrombotic thrombocytopenic purpura, disseminated intravascular coagulation (DIC), disseminated cancer, hemolytic-uremic syndrome, lupus erythematosus and polyarteritis nodosa that can also lead to traumatic hemolytic anemia because of damaged small blood vessels. (nethealthbook.com)

Hemolytic anemia can be extrinsic or intrinsic. (healthline.com)
Intrinsic hemolytic anemia develops when the red blood cells produced by your body don't function properly. (healthline.com)
Inherited (or intrinsic) hemolytic anemia is caused by a defect in the red blood cells themselves and results when one or more genes that control red blood cell production don't function properly. (childrenshospital.org)
The general classification of hemolytic anemia is either intrinsic or extrinsic. (wikipedia.org)
The causes of hemolytic anemia may be either intrinsic, or extrinsic. (oncologynurseadvisor.com)
Intrinsic causes of hemolytic anemia are specific problems of the red blood cell, and are typically hereditary. (oncologynurseadvisor.com)
There are two types of hemolytic anemia, intrinsic and extrinsic. (nyhq.org)
Intrinsic hemolytic anemias are often inherited, such as sickle cell anemia and thalassemia. (nyhq.org)

Acquired hemolytic anemia may be caused by immune-mediated causes, drugs and other miscellaneous causes. (wikipedia.org)
Immune-mediated causes could include transient factors as in Mycoplasma pneumoniae infection ( cold agglutinin disease ) or permanent factors as in autoimmune diseases like autoimmune hemolytic anemia (itself more common in diseases such as systemic lupus erythematosus , rheumatoid arthritis , Hodgkin's lymphoma , and chronic lymphocytic leukemia ). (wikipedia.org)
Acquired haemolytic anaemia can be further divided into immune and non-immune mediated. (bionity.com)
They determined that she had Immune-Mediated Hemolytic Anemia (IMHA), a condition where her immune system attacks her own body. (shirleys-wellness-cafe.com)
My beautiful dog, Bea, passed away yesterday from a horrible illness called IMHA - Immune Mediated Hemolytic Anemia. (thriftyfun.com)
Dogs with immune-mediated hemolytic anemia are usually 2 to 8 years old and female. (petcarerx.com)
Immune Mediated Hemolytic Anemia can be a primary autoimmune disease that attacks red blood cells or secondary to infection with mycoplasma, a tick-borne parasite and some tumors. (ashgi.org)

Blood transfusions can be used in dogs with IMHA if necessary but they can make the condition worse so most vets reserve this approach for dogs that appear to be in imminent danger of dying due to severe anemia. (vetinfo.com)
These examinations may help rule out causes of anemia other than IMHA, or may help identify triggers that preceded development of IMHA. (petplace.com)

Immune hemolytic anemia occurs when antibodies form against the body's own red blood cells and destroy them. (medlineplus.gov)
When antibodies form against red blood cells for no reason, the condition is called idiopathic autoimmune hemolytic anemia. (medlineplus.gov)
Screening for antibodies in donated blood and in the recipient may prevent hemolytic anemia related to blood transfusions. (medlineplus.gov)
Often, the antibodies and anemia go away once the infection has gone. (medicalnewstoday.com)
Autoimmune hemolytic anemia is an immune disorder caused by antibodies directed against autologous red cells. (hindawi.com)
Acquired (or extrinsic) hemolytic anemia is caused by factors outside the red blood cell, such as antibodies from an autoimmune disorder, burns or drug medications. (childrenshospital.org)
The immune hemolytic anemias are classified according to the optimal temperature at which the antibodies act to destroy red blood cells. (rarediseases.org)
In cold antibody anemia, the auto antibodies turn active and affect RBC at a temperature below the standard body temperatures. (womenhealthzone.com)
In the warm form of antibody anemia, the auto antibodies are attached to and destroy red blood cells at temperature which is of or higher than the usual body temperature. (womenhealthzone.com)
The presence of autoimmune hemolytic anemia can be confirmed with the help of blood tests that detect the presence of enhanced numbers of antibodies which may be attached to the RBC (found through Coombs or direct antiglobulin test) or on the liquid part of your blood (found through Coombs or indirect antiglobulin test). (womenhealthzone.com)
Warm agglutinin disease accounts for the majority of autoimmune hemolytic anemia and is generally mediated by IgG antibodies to the Rh system of erythrocytes. (oncologynurseadvisor.com)
Paroxysmal cold hemoglobinuria is a self-limiting autoimmune hemolytic anemia mediated by IgG antibodies names Donath-Landsteiner antibodies directed against P antigen on erythrocytes. (oncologynurseadvisor.com)
C3d: Also known as the Anti-Human Globulin Anti-IgG is a direct antiglobulin test to determine the presence of in-vivo coating of red blood cells with antibody molecules and/or complement components (like autoantibodies, maternal antibodies in hemolytic disease of the newborn, and alloantibodies against red blood cells in transfusion reactions) (Biotest Medical Diagnostics, 2008). (mindmeister.com)
Hemolytic Disease of the New born (HDN) First Pregnancy Rh+ve fetus in Rh-ve mother-no antibodies present. (scribd.com)
Autoimmune hemolytic anemia is caused by antibodies that are directed against red blood cells. (nethealthbook.com)
Autoimmune hemolytic anemia due to warm antibodies (wAIHA) accounts for approximately 70% to 80% of all AIHAs in adults. (em-consulte.com)

Hemolytic anemia occurs when the bone marrow isn't making enough red cells to replace the ones that are being destroyed. (medlineplus.gov)
When destruction of red blood cells outpaces your bone marrow's production of these cells, hemolytic anemia occurs. (healthline.com)
Extrinsic hemolytic anemia develops by several methods, such as when the spleen traps and destroys healthy red blood cells, or an autoimmune reaction occurs. (healthline.com)
Hemolytic disease of the newborn is a condition that occurs when a mother and baby have incompatible blood types, usually because of Rh incompatibility. (healthline.com)
In hemolytic anemia, a loss of red blood cells (rbcs) occurs due to destruction of the rbcs. (vetinfo.com)
Anemia occurs when there are insufficient red blood cells, or they don't function properly. (drugs.com)
Anemia occurs when you do not have enough healthy red blood cells to carry oxygen to your tissues. (healthline.com)
Hemolytic anemia is a type of blood disorder that occurs when the body has fewer red blood cells than normal. (childrenshospital.org)
Congenital Hemolytic Anemia is a general term for hemolytic anemia that is present from birth and in which the lifespan of red blood cells is diminished, such as occurs in hereditary spherocytosis . (diagnose-me.com)
Infectious causes should be considered in all patients with hemolytic anemia that was preceded by or occurs concurrently with fever, and in patients with underlying immunodeficiency. (oncologynurseadvisor.com)
Anemia occurs when the rate of destruction exceeds the rate of production of additional red blood cells by the bone marrow. (renalandurologynews.com)
This occurs when the red blood cells are attacked by the dog's own immune system, and is the most common form of hemolytic anemia in dogs past puppyhood. (petcarerx.com)

Depending on the type of hemolytic anemia, symptoms can be mild or very severe. (kidshealth.org)
Treatment options and prognosis depend on knowing what specific type of hemolytic anemia your dog has. (petcarerx.com)

There are different types of hemolytic anemia such as Hemoglobin SC Disease, hemolytic anemia due to G6PD deficiency, hereditary ovalocytosis, hereditary elliptocytosis, idiopathic autoimmune hemolytic anemia and many others. (womenhealthzone.com)

The etiology of severe hemolytic anemia in most patients with recessive hereditary spherocytosis (rHS) and the related disorder hereditary pyropoikilocytosis (HPP) is unknown. (jci.org)

Some types of extrinsic hemolytic anemia are temporary and go away over several months. (nationwidechildrens.org)

This condition is often inherited, such as in people with sickle cell anemia or thalassemia , who have abnormal hemoglobin. (healthline.com)
It includes sickle cell anemia, thalassemia, or erythrocytosis. (nationwidechildrens.org)
Leg ulcers occur in some chronic hemolytic states, such as sickle cell anemia. (aafp.org)
Hemoglobin disorders (sickle cell anemia, thalassemia). (renalandurologynews.com)
Sickle cell anemia and Thalassemia are also subtypes of this anemia. (womenhealthzone.com)
Sickle cell anemia is a disease passed down through families. (limamemorial.org)

A rare form of the disorder is hemolytic anemia from a lack of glucose-6 phosphate dehydrogenase (G6PD) . (limamemorial.org)

Michel M. Autoimmune and intravascular hemolytic anemias. (medlineplus.gov)
Paroxysmal nocturnal hemoglobinuria (PNH), sometimes referred to as Marchiafava-Micheli syndrome, is a rare, acquired, potentially life-threatening disease of the blood characterized by complement-induced intravascular hemolytic anemia. (wikipedia.org)
DLHA, also known as paroxysmal cold hemoglobinuria, is an intravascular hemolytic anemia caused by a cold-reacting immunoglobulin (Ig). (medscape.com)

National Organization for Rare Disorders: "Anemia, Hemolytic, Acquired Autoimmune. (webmd.com)
Anemia resulting from the abnormal destruction of of red blood cells, as in response to certain toxic or infectious agents and in certain inherited blood disorders. (dictionary.com)
Anemia resulting from the lysis of red blood cells, as in response to certain toxic or infectious agents and in certain inherited blood disorders. (dictionary.com)
Hemolytic anemia is a group of disorders in which the red blood cells are destroyed faster than the bone marrow can make them. (nationwidechildrens.org)
Disorders of red blood cell enzymes, membranes, and hemoglobin cause hereditary hemolytic anemias. (aafp.org)
and not enough family members can be tested to differentiate between hereditary intracorpuscular hemolytic disorders and acquired extracorpuscular defects. (medscape.com)
Children and teens with hematolytic anemia are treated through the Blood Disorders Center at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, an integrated pediatric hematology and oncology partnership between Dana-Farber Cancer Institute and Boston Children's Hospital - and a world leader in the treatment and research of all types of pediatric blood disorders. (childrenshospital.org)
The differential diagnoses are rifampicin or probenecid use, inherited disorders like Gilbert's syndrome and other hemolytic disorders. (wikipedia.org)
Hereditary hemolytic anemia encompasses a heterogeneous group of anemias characterized by decreased red blood cell survival because of inherited membrane, enzyme, or hemoglobin disorders. (frontiersin.org)
Idiopathic autoimmune hemolytic anemia is known as a rare collection of disorders which can strike the patient at any age group. (womenhealthzone.com)

Efficacy and safety of rituximab in adults' warm antibody autoimmune haemolytic anemia: retrospective analysis of 27 cases," American Journal of Hematology , vol. 84, no. 3, pp. 153-157, 2009. (hindawi.com)

What Are the Signs & Symptoms of Hemolytic Anemia? (kidshealth.org)
In general, signs of anemia ( pallor , fatigue, shortness of breath, and potential for heart failure ) are present. (wikipedia.org)
Signs of anemia are generally present ( fatigue , later heart failure ). (bionity.com)
Though the readily observable symptoms of hemolytic anemia are similar to those of other types of anemias, there are several signs that can aid in a more specific diagnosis. (microscopyu.com)
Some key signs of the hemolytic form of the condition are only recognizable with the aid of a microscope. (microscopyu.com)
Symptoms of hemolytic anemia are similar to the general signs of anemia. (wikipedia.org)
Dogs suffering from autoimmune hemolytic anemia typically show the same signs as dogs suffering from other forms of anemia. (petwave.com)

A number of pathogens including viruses, bacteria, parasites and fungi may cause hemolytic anemias. (oncologynurseadvisor.com)
Quantitative and functional abnormalities of certain RBC membrane proteins (alpha- and beta-spectrin, protein 4.1, F-actin, ankyrin) cause hemolytic anemias. (merckmanuals.com)

Extrinsic nonimmune hemolytic anemias. (medscape.com)

Go to Anemia , Iron Deficiency Anemia , and Chronic Anemia for complete information on these topics. (medscape.com)
B-cell depletion with rituximab as treatment for immune hemolytic anemia and chronic thrombocytopenia," Haematologica , vol. 87, no. 2, pp. 189-195, 2002. (hindawi.com)
Autoimmune hemolytic anemia can occur in patients who have chronic lymphocytic leukemia (CLL). (fpnotebook.com)
Go to Pediatric Chronic Anemia , Anemia of Prematurity , Fanconi Anemia , Pediatric Acute Anemia , and Pediatric Megaloblastic Anemia for complete information on these topics. (medscape.com)
Hemolytic Anemia includes any of a group of acute or chronic anemias characterized by shortened survival of mature erythrocytes and the inability of bone marrow to compensate for the decreased life span. (diagnose-me.com)
Anemia as a result of chronic inflammation is a characteristic but not especially common feature of active SLE. (diagnose-me.com)
The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia. (jci.org)
A 85-year-old female treated for chronic inflammatory demyelinating polyradiculoneuropathy had three episodes of anaemia one week following treatment with large doses (2g/kg body weight) of immunoglobulin (Ig). (prohealth.com)

Rituximab for warm-type idiopathic autoimmune hemolytic anemia: a retrospective study of 11 adult patients," European Journal of Haematology , vol. 79, no. 1, pp. 53-58, 2007. (hindawi.com)
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies," Blood , vol. 119, no. 16, pp. 3691-3697, 2012. (hindawi.com)

If a mother has a negative Rh blood type and her baby's father has a positive one, there's a chance hemolytic disease of the newborn can occur if the baby's red blood cells are then positive for Rh factor. (healthline.com)
Examples of problems that can lead to hemolytic anemia include ehrlichiosis (a blood parasite), reactions to sulfa antiseptics or penicillin antibiotics, zinc toxicosis -- which can occur due to the ingestion of pennies. (vetinfo.com)
In small children, failure to thrive may occur in any form of anemia. (wikipedia.org)
In rare cases, death can occur as a result of severe anemia. (healthline.com)
If hemolytic anemia symptoms are seen later in life, they could occur due to abnormal immune system responses, certain infections and reactions to certain medications and in cases, due to blood clots in small blood vessels. (womenhealthzone.com)
Essentially there are three mechanisms by which hemolytic anemia can occur. (nethealthbook.com)
Autoimmune hemolytic anemia is known to occur in patients infected with infectious mononucleosis, cytomegalovirus (CMV), Mycoplasma pneumonia, Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), viral hepatitis, and human parvovirus B-19. (daisygreenmagazine.co.uk)

Protein which, if defective, causes hereditary hemolytic anemia, a hereditary disease characterized by the premature destruction of red blood cells. (uniprot.org)
In all hemolytic anemias, there is excessive destruction of red blood cells. (rarediseases.org)
Hemolytic anemia is caused by the destruction of red blood cells that exceeds the ability of the bone marrow to replace them. (oncologynurseadvisor.com)
A condition which is characterized by anaemia due to the destruction of red blood cells. (rightdiagnosis.com)
The condition called hemolytic anemia is caused by a rapid and premature destruction of red blood cells. (womenhealthzone.com)

See also Overview of Hemolytic Anemia . (merckmanuals.com)

There are several possible causes of hemolytic anemia. (medlineplus.gov)
The following drugs, medications, substances or toxins are some of the possible causes of Hemolytic anemia as a symptom. (rightdiagnosis.com)

The following are the most common symptoms of hemolytic anemia. (nyhq.org)

These results demonstrate that a unique mechanism of human genetic disease contributes to the etiology of a third of rHS cases, facilitating diagnosis and treatment of severe anemia and identifying a new target for therapeutic manipulation. (jci.org)

The thrombotic thrombocytopenic purpura and hemolytic uremic syndromes: overview of pathogenesis (Experience of The Oklahoma TTP-HUS Registry, 1989-2007). (medscape.com)

Hemolytic disease of the newborn is a problem because the baby can become significantly anemic, which causes further complications. (healthline.com)

American Association of Clinical Chemistry: "Hemolytic Anemias. (webmd.com)
Clinical findings in haemolytic anaemias: 1. (bionity.com)
Case reports were considered relevant if the patient had received artesunate therapy for the treatment of severe malaria and then experienced worsening hemolytic anemia after initial clinical improvement and resolution of parasitemia. (cdc.gov)
1 The Coombs test is an essential diagnostic test in the clinical approach to hemolytic anemia because of its substantial positive predictive value and its ability to differentiate warm from cold autoantibodies. (jaoa.org)

3 Second, the patient in this case 1 received only 40 mg/d of prednisone-below the current weight-dependent guidelines of 1 mg/kg prednisone (usually administered in dosages of 60-100 mg/d) for patients with hemolytic anemia. (jaoa.org)
3 Most patients with hemolytic anemia will require this dosage for 1 to 3 weeks, while 20% to 30% of patients will be refractory to steroids and will require other treatment modalities, such as rituximab, cyclophosphamide, intravenous immunoglobulin, or a splenectomy. (jaoa.org)

Two forms of cold antibody autoimmune hemolytic anemias are generally recognized: Donath-Landsteiner hemolytic anemia (DLHA) and cold agglutinin disease. (medscape.com)

Anemia is when the number of red blood cells in the body gets too low. (kidshealth.org)
Hemolytic (hee-muh-LIT-ik) anemia is a type of anemia that happens when red blood cells break down faster than the body can make them. (kidshealth.org)
A hematologist (a doctor who treats blood problems) helps children with hemolytic anemia get the treatment they need. (kidshealth.org)
Anemia is a condition in which the body does not have enough healthy red blood cells. (medlineplus.gov)
In hemolytic anemia, red blood cells in the blood are destroyed earlier than normal. (medlineplus.gov)
A test called a complete blood count (CBC) can help diagnose anemia and offer some hints to the type and cause of the problem. (medlineplus.gov)
Hemolytic anemias: red blood cell membrane and metabolic defects. (medlineplus.gov)
Autoimmune hemolytic anemia is a rare red blood cell disorder and an immune disorder. (medicalnewstoday.com)
Hemolytic anemia develops when there are not enough red blood cells because the body destroys them sooner than it should. (medicalnewstoday.com)
They destroy the red blood cells, and this results in anemia. (medicalnewstoday.com)
National Heart, Lung, and Blood Institute: "How is Hemolytic Anemia Diagnosed? (webmd.com)
The patient was diagnosed with drug-induced autoimmune hemolytic anemia (DIIHA) secondary to fluoroquinolone use and was treated supportively with intravenous hydration and red blood cells transfusions. (hindawi.com)
One of the most severe forms of hemolytic anemia is the kind caused by receiving a red blood cell transfusion of the wrong blood type. (healthline.com)
Finding spherocytes on a blood smear almost guarantees that some form of hemolytic anemia is occurring. (vetinfo.com)
Since this disorder does not stop the production of red blood cells, there are usually immature red blood cells in the bloodstream which can be detected on the blood smears as well (a regenerative anemia). (vetinfo.com)
Review of the peripheral blood smear is a critical step in the evaluation of any anemia. (aafp.org)
An acquired anemia caused by destruction of the red blood cells by autoantibodies. (fpnotebook.com)
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS. (fpnotebook.com)
This can cause your immune system to break down red blood cells, and consequently lead to anemia. (healthline.com)
Blood typing should be performed on all patients even if anemia is mild. (medscape.com)
If the anemia is severe or rapidly progressive, however, supportive care with transfusions of packed red blood cells may be warranted. (medscape.com)
In children with hemolytic anemia, the low red blood cell count is caused by the destruction, rather than the underproduction, of red blood cells. (childrenshospital.org)
Hereditary spherocytic hemolytic anemia is a rare blood disorder characterized by defects within red blood cells (intracorpuscular) that result in a shortened survival time for these cells. (rarediseases.org)
An infection is the most common cause of the temporary failure of the bone marrow to produce blood components (aplastic crisis) in people with hereditary spherocytic hemolytic anemia. (rarediseases.org)
Hemolytic anemias, including hereditary spherocytic hemolytic anemia, have two distinct laboratory findings: a reduction in the life span of red blood cells and the retention of iron within the body particularly in those cells that have the ability to dispose of wastes and toxins (reticuloendothelial system or RES). (rarediseases.org)
The severity of the anemia is determined by the length of time that the red blood cells survive and by the rate at which the bone marrow continues to create new red blood cell production. (rarediseases.org)
Other indicators that an individual's anemia is hemolytic include elevated levels of lactate dehydrogenase and unbound bilirubin in the blood as well as a decrease in the protein haptoglobin. (microscopyu.com)
George Hoyt Whipple, a Nobel prize winner, and W. L. Bradford, a professor of pediatrics at the University of Rochester, coined the term thalassemia in 1936, which in Greek means anemia of the sea (Thalassa means "sea", and emia means "blood"), due to the fact that it is very common in the area of the Mediterranean Sea. (intechopen.com)
Hereditary (inherited) hemolytic anemia can be due to : Defects of red blood cell membrane production (as in hereditary spherocytosis and hereditary elliptocytosis). (wikipedia.org)
It is identified by the finding of anemia and schistocytes on microscopy of the blood film. (wikipedia.org)
In hereditary hemolytic anemias, the underlying molecular defect affects and determines red blood cell vesiculation, resulting in shedding microvesicles of different compositions and concentrations. (frontiersin.org)
Despite extensive research into red blood cell biochemistry and physiology, little is known about red cell deformability and vesiculation in hereditary hemolytic anemias, and the associated pathophysiological role is incompletely assessed. (frontiersin.org)
Also, we review recent scientific findings on the molecular defects of hereditary hemolytic anemias, and their correlation with red blood cell deformability and vesiculation. (frontiersin.org)
Integrating bio-analytical findings on abnormalities of red blood cells and their microvesicles will be critical for a better understanding of the pathophysiology of hereditary hemolytic anemias. (frontiersin.org)
This is an uncommon anemia that develops when red blood cells are destroyed faster than bone marrow can replace them. (diagnose-me.com)
Infectious Hemolytic Anemia is due to an incompletely compensated decrease in red blood cell survival secondary to infectious agents, including protozoa (e.g. (diagnose-me.com)
If hemolytic anemia is present, there will be a higher number of young red blood cells than normal. (diagnose-me.com)
Malaria may cause anemia because of the loss of red blood cells . (diagnose-me.com)
Complete blood count (CBC) should be performed on all dogs suspected of having anemia (decreased number of red blood cells), regardless of the cause. (petplace.com)
Autoimmune hemolytic anemia (aw-toe-ih-MEWN HEE-mah-lih-tik a-NEE-mee-a) is a disease of the immune system that causes red blood cells to break open or lyse (break down). (stjude.org)
This causes anemia (low red blood cell levels). (stjude.org)
When red blood cell levels are low, patients have anemia. (stjude.org)
Confirm that the hemolytic anemia is due to microangiopathy by identification of schistocytes on the peripheral blood smear. (renalandurologynews.com)
Congenital hemolytic anemia (CHA) can be caused by the defect of any component in red blood cell (RBC), including hemoglobinopathies, membrane and cytoskeleton defects, and metabolic enzymopathies etc. (lww.com)
Anemia is a low level of healthy red blood cells (RBCs). (epnet.com)
Sometimes it could be conditions such as pulmonary high blood pressure (which may cause fainting or chest pain) or increased incidence of gall stones (because of increased excretion of bilirubin) that may alert a woman that she has hemolytic anemia. (womenhealthzone.com)
The free hemoglobin count in blood and urine can indicate hemolytic anemia. (womenhealthzone.com)
Once the diagnosis has been made based on hemolytic anemia symptoms and the results of the blood tests and other diagnostics, the doctor can decide how best to treat the condition. (womenhealthzone.com)
Hemolytic anemia is a form of anemia that speeds up the natural process of red blood cells. (petcarerx.com)
Hemolytic anemia in dogs is a type of anemia in which the otherwise natural cycle of red blood cells is sped up. (petcarerx.com)
Anemia " means a shortage of red blood cells in your pet's body, which can have a serious negative impact on how their organ's function. (petcarerx.com)
The blood tests show the hallmarks of a hemolytic anemia with a low mean corpuscular volume (MCV), but a high distributions width due to the fragments of red blood cells in the blood. (nethealthbook.com)
Autoimmune hemolytic anemia is an autoimmune disorder in which red blood cells are destroyed, causing a severe, acute form of anemia. (daisygreenmagazine.co.uk)
In their December 2007 case report, Damon L. Baker, DO, and colleagues 1 concluded that their patient's elevated lactate dehydrogenase level and reticulocyte count indicated hemolytic anemia, and that the results from a peripheral blood smear suggested normocytic anemia with granulocytosis and thrombocytosis. (jaoa.org)
Also arguing against a diagnosis of hemolytic anemia in the case report by Baker et al 1 was the lack of spherocytosis, anisocytosis, and polychromatophilia on the patient's peripheral blood smear. (jaoa.org)
When red blood cell destruction is severe, blood transfusions are sometimes needed, but they do not treat the cause of the anaemia and provide only temporary relief. (ndtv.com)
Dogs that show symptoms of anemia are usually tested for complete blood count, a urinalysis, and have a serum biochemistry test done. (justusdogs.com.au)
Hemolytic anemia is a disorder in which the red blood cells are destroyed faster than the bone marrow can produce them. (nyhq.org)
The symptoms of hemolytic anemia may resemble other blood conditions or medical problems. (nyhq.org)

Piriyakhuntorn P, Tantiworawit A, Rattanathammethee T, Chai-Adisaksopha C, Rattarittamrong E, Norasetthada L. The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients. (medscape.com)
George Hoyt Whipple, a Nobel prize winner, and W. L. Bradford, a professor of pediatrics at the University of Rochester, coined the term thalassemia in 1936, which in Greek means anemia of the sea (Tha. (intechopen.com)

Singh A, Mandal A, Patel A, Mishra S. Autoimmune Haemolytic Anaemia-A Spectrum of Presentation in Children. (medscape.com)
In autoimmune haemolytic anaemia direct antiglobulin test also referred to as direct Coombs test is positive. (ndtv.com)

Questionable Diagnosis of Hemolytic Anemia? (jaoa.org)
All patients with a first-ever diagnosis of hemolytic anemia from either specialist outpatient clinic contact or inpatient admission at Odense University Hospital from January 1994 through December 2011 were considered for inclusion. (dovepress.com)

Hereditary spherocytosis (HS) is the most common type of hereditary hemolytic anemia. (frontiersin.org)

Autoimmune hemolytic anemia following allogeneic hematopoietic stem cell transplantation in adult patients. (medscape.com)
Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation. (medscape.com)

Anatomy12

Organisms18

Diseases70

Chemicals and Drugs89

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology1

Phenomena and Processes32

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Extraction of erythrocyte membrane proteins by sulfhydryl inhibitors. (1/616)

Reduced glutathione accelerates the oxidative damage produced by sodium n-propylthiosulfate, one of the causative agents of onion-induced hemolytic anemia in dogs. (2/616)

Rumen bacteria are involved in the onset of onion-induced hemolytic anemia in sheep. (3/616)

Erythroid accelerating activity of rat serum in early stage of drug induced hemolysis. (4/616)

Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation. (5/616)

The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency. (6/616)

Molecular basis and enzymatic properties of glucose 6-phosphate dehydrogenase volendam, leading to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections. (7/616)

Reversal of metabolic block in glycolysis by enzyme replacement in triosephosphate isomerase-deficient cells. (8/616)

Anemia

Anemia, Hemolytic

Anemia, Hemolytic, Autoimmune

Anemia, Hemolytic, Congenital

Hemolysis

Anemia, Aplastic

Hemolytic Agents

Fanconi Anemia

Anemia, Hemolytic, Congenital Nonspherocytic

Hemolytic-Uremic Syndrome

Anemia, Hypochromic

Anemia, Macrocytic

Anemia, Pernicious

Anemia, Sickle Cell

Hemolysin Proteins

Hemoglobins

Anemia, Sideroblastic

Erythrocytes

Coombs Test

Anemia, Megaloblastic

Infectious Anemia Virus, Equine

Anemia, Refractory

Complement Hemolytic Activity Assay

Erythropoietin

Hemolytic Plaque Technique

Equine Infectious Anemia

Erythroblastosis, Fetal

Phenylhydrazines

Chicken anemia virus

Spherocytosis, Hereditary

Anemia, Dyserythropoietic, Congenital

Iron

Heinz Bodies

Erythrocyte Count

Anemia, Diamond-Blackfan

Fanconi Anemia Complementation Group Proteins

Pregnancy Complications, Hematologic

Reticulocyte Count

Hematocrit

Erythrocyte Aging

Osmotic Fragility

Erythropoiesis

Erythrocytes, Abnormal

Anemia, Neonatal

Blood Transfusion

Glucosephosphate Dehydrogenase Deficiency

Hematinics

Anemia, Refractory, with Excess of Blasts

Erythrocyte Indices

Erythrocyte Membrane

Fanconi Anemia Complementation Group C Protein

Rh-Hr Blood-Group System

Fanconi Anemia Complementation Group D2 Protein

Fanconi Anemia Complementation Group A Protein

Hemoglobinometry

Complement System Proteins

Streptolysins

Ferritins

Pallor

Erythrocyte Transfusion

Complement Factor H

Shiga Toxin

Blood Group Incompatibility

Hemoglobins, Abnormal

Splenectomy

Antimicrobial Cationic Peptides

Splenomegaly

Cytotoxins

Thrombotic Microangiopathies

Molecular Sequence Data

Hemoglobinuria, Paroxysmal

Reticulocytes

Complement Activation

Rh Isoimmunization

Bacterial Toxins

Fanconi Anemia Complementation Group G Protein

Thrombocytopenia

Horses

Plasma Exchange

Thalassemia