Androsterone: A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.Etiocholanolone: The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.Glucuronosyltransferase: A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.17-Ketosteroids: Steroids that contain a ketone group at position 17.3-alpha-Hydroxysteroid Dehydrogenase (B-Specific): A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.Rats, Gunn: Mutant strain of Rattus norvegicus which is used as a disease model of kernicterus.Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.Phenolphthaleins: A family of 3,3-bis(p-hydroxyphenyl)phthalides. They are used as CATHARTICS, indicators, and COLORING AGENTS.NitrophenolsEpitestosterone: The 17-alpha isomer of TESTOSTERONE, derived from PREGNENOLONE via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse.Androstanes: The family of steroids from which the androgens are derived.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.Comamonas testosteroni: A species of gram-negative, aerobic rods formerly called Pseudomonas testosteroni. It is differentiated from other Comamonas species by its ability to assimilate testosterone and to utilize phenylacetate or maleate as carbon sources.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Glucuronates: Derivatives of GLUCURONIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the 6-carboxy glucose structure.Androstane-3,17-diol: The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.Cholestenone 5 alpha-Reductase: An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. It plays an important role in the conversion of TESTOSTERONE into DIHYDROTESTOSTERONE and PROGESTERONE into DIHYDROPROGESTERONE.3-Hydroxysteroid Dehydrogenases: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Biogenic Amines: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.Hydroxysteroid Dehydrogenases: Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.Estriol: A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.Theca Cells: The flattened stroma cells forming a sheath or theca outside the basal lamina lining the mature OVARIAN FOLLICLE. Thecal interstitial or stromal cells are steroidogenic, and produce primarily ANDROGENS which serve as precusors of ESTROGENS in the GRANULOSA CELLS.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.

Androgen secreting adrenocortical tumours. (1/160)

BACKGROUND: Androgen secreting adrenocortical tumours are rare in children and the determination of their malignant potential can be difficult. OBJECTIVES: To assess the presentation, histology, and clinical behaviour of these tumours. SETTING: Two tertiary referral centres. STUDY DESIGN: Retrospective analysis of children diagnosed with an androgen secreting adrenocortical tumour between 1976 and 1996. PATIENTS: Twenty three girls and seven boys aged 0-14 years. RESULTS: Pubic hair was observed in all children, clitoromegaly or growth of the phallus in 23 children, acceleration of linear growth in 22 children, and advanced bone age (> 1.5 years) in 18 children. Hypersecretion of androgens was detected by assessment of serum androgen concentrations alone in four patients and by 24 hour urine steroid excretion profiles in 22 patients. All 16 tumours measuring < 5 cm in diameter were benign. Of the tumours measuring 5-9 cm, three were malignant and seven were benign, whereas all four tumours > 10 cm were malignant. Histological slides were available for reassessment in 25 children. Although mitoses and necrosis were more characteristic of tumours with malignant behaviour, no exclusive histological features of malignancy were seen. CONCLUSION: Histological criteria for malignancy are not reliable, whereas tumour size is important in assessing malignant potential.  (+info)

Identification by chimera formation and site-selected mutagenesis of a key amino acid residue involved in determining stereospecificity of guinea pig 3-hydroxysteroid sulfotransferase isoforms. (2/160)

The 3-hydroxysteroid sulfotransferases that have been isolated and cloned from humans and rodents appear to have broad substrate specificities. In the guinea pig, however, two 3-hydroxysteroid sulfotransferases have been isolated that function according to an innate stereospecificity: the alpha-isoform acts on steroids with a 3-hydroxyl group oriented in the alpha position, whereas the beta-isoform acts on steroids where the 3-hydroxyl group is in a beta orientation. To examine the structural basis for this remarkable stereoselectivity, chimeras of the two enzymes, which are 87% identical, were constructed. A chimera consisting of the NH(2)-terminal 91 amino acids of the alpha-isoform and the COOH-terminal 196 amino acids of the beta-isoform displayed activity similar to that of the alpha-isoform. Site-selected mutagenesis of this 3alpha/beta-hydroxysteroid sulfotransferase chimera involving the 12 amino acid differences that exist between the two isoforms within the 91 amino acid NH(2)-terminal region revealed that the amino acid residue at position 51 plays a fundamental role in determining the stereospecificity exhibited by the alpha- and beta-isoforms, i.e. if residue 51 is an asparagine, alpha activity predominates, whereas if an isoleucine is in that position, beta activity prevails.  (+info)

Dexamethasone-induced apoptosis of mouse thymocytes: prevention by native 7alpha-hydroxysteroids. (3/160)

Dehydroepiandrosterone (DHEA) has been shown to decrease the dexamethasone (DEX)-induced apoptosis of thymocytes and to be one of the native 3beta-hydroxysteroids extensively 7alpha-hydroxylated in thymus. This led us to question whether DHEA or 7alpha-hydroxy-DHEA is responsible for the decrease in DEX-induced apoptosis of thymocytes and whether this property is shared with other native 3beta-hydroxysteroids and their 7alpha-hydroxylated metabolites. Treatment of mice with DHEA or 7alpha-hydroxy-DHEA prior to DEX led to a smaller decrease in thymus weight than with DEX alone and to a disappearance of the DEX-induced changes in thymocyte phenotypes. Thymocyte apoptosis induced by DEX treatment was significantly lowered in DHEA- and 7alpha-hydroxy-DHEA-treated thymi, even after 18 h culture with additional 10-6 mol/L DEX. Extensive apoptosis of thymocytes cultured with 10-7 mol/L DEX was brought back to control levels when 10-5 mol/L 7alpha-hydroxy-DHEA or 10-5 mol/L 7alpha-hydroxy-epiandrosterone was added. After use of DHEA and epiandrosterone or pregnenolone, less significant and no significant changes were obtained, respectively. These findings imply that the 7alpha-hydroxylation of 3beta-hydroxysteroids may be a prerequisite for an exquisite regulation of the thymocyte-positive selection driven by the glucocorticoids produced in thymic epithelial cells.  (+info)

Hormone profiles in hormone-dependent cancers. (4/160)

Studies on the relationship of urinary excretion of androgen metabolites and estrogens to the natural history of breast cancer are reviewed. The importance of distinguishing between "within-population" studies (i.e., cancer patients versus normal controls) and "between populations" studies (i.e., low-risk versus high-risk populations) is emphasized, and it is pointed out that "qualitative" agreement (i.e. the same direction of differences) between the two types of studies must be present in order to implicate a hormonal parameter as a determinant of the natural history of breast cancer. For reasons detailed in this paper, it is concluded that the reported relationship of low urinary androgen metabolite excretion to increased risk of developing breast cancer and poor response to adrenalectomy or hypophysectomy and the validity of the "estriol hypothesis," namely, that a high urinary ratio of estriol to estrone-plus-estradiol in early life is protective against subsequent development of breast cancer, are both dubious. A new hypothesis concerning the relationship of estrogens to breast cancer risk is presented: "A period of of time, prior to age 30, during which the amount of biological availability of active estrogens' (i.e., estrone and estradiol) is diminished, protects against subsequent development of cancer." This hypothesis is shown to be compatible with the epidemiological and biochemical data. Reports concerning the influence of nutrition on endocrine parameters are reviewed. Inanition and obesity have been shown to alter steroid metabolism but it is not known whether nutritional "microdifferences" (i.e., differences between populations or individuals that are due to cultural, geographic, or socioeconomic factors, but that fall within the range of "normal" or adequate nutrition) can also alter steroid metabolism.  (+info)

Strain differences in rat liver (UDP-glucuronyltransferase activity towards androsterone. (5/160)

Male Donryu, Wistar King rats showed discontinuous variations in hepatic microsomal UDP-glucuronyltransferase activities towards androsterone, but not towards testosterone, bilirubin, phenolphthalein and 4-nitrophenol. Fresh microsomal fraction with a low transferase activity towards androsterone formed 0.049--0.080 nmole of glucuronide/min per mg of protein, whereas fresh microsomal fraction with a high transferase activity towards androsterone formed 0.335--0.557 nmol of glucuronide/min per mg of protein. The microsomal fraction with low enzyme activity towards androsterone was not stimulated by treatment with Triton X-100 or freezing and thawing. In contrast, male Long Evans and Sprague-Dawley rats did not exhibit such diversity.  (+info)

Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men. (6/160)

Men with higher endogenous 5alpha-reductase activity may have higher prostate cancer risk. This hypothesis raises two questions: (a) Could racial differences in 5alpha-reductase activity explain the observed racial differences in prostate cancer risk? and (b) Could a man reduce his activity level by modifying his lifestyle? To address these questions, we measured two hormonal indices of 5alpha-reductase activity [serum levels of androstane-3alpha-17beta-diol glucuronide (3alpha-diol G) and androsterone glucuronide (AG)] in healthy, older African-American, white, and Asian-American men, who are at high, intermediate, and low prostate cancer risk, respectively. We also examined associations between these metabolite levels and such lifestyle characteristics as body size and physical activity as well as select aspects of medical history and family history of prostate cancer. Men included in this cross-sectional analysis (n = 1054) had served as control subjects in a population-based case-control study of prostate cancer we conducted in California, Hawaii, and Vancouver, Canada and provided information on certain personal attributes and donated blood between March 1990 and March 1992. In this study, concentrations of 3alpha-diol G declined significantly with age and increased significantly with body mass index. Mean levels of 3alpha-diol G, adjusted for age and body mass index, were 6.1 ng/ml in African-Americans, 6.9 ng/ml in whites and 4.8 ng/ml in Asian-Americans. These differences were statistically significant (African-Americans versus whites: P < 0.01; whites versus Asian-Americans: P < 0.001). Concentrations of AG decreased significantly with age, but only in whites, and were unrelated to any of the reported personal attributes. Mean levels of AG, adjusted for age, were 44.1 ng/ml in African-Americans, 44.9 ng/ml in whites, and 37.5 ng/ml in Asian-Americans (Asian-Americans versus whites, P < 0.001). In conclusion, older African-American and white men have similar levels of these two indices of 5alpha-reductase activity, and these levels are higher than those of older Asian-American men. This difference may be related to the lower prostate cancer risk in Asian-Americans.  (+info)

16alpha-bromoepiandrosterone, a dehydroepiandrosterone (DHEA) analogue, inhibits Plasmodium falciparum and Plasmodium berghei growth. (7/160)

Dehydroepiandrosterone (DHEA) and its analogue, 16alpha-bromoepiandrosterone (alpha-epi-Br), may have activity against viral and parasitic infections, including human immunodeficiency virus (HIV) and Cryptosporidium parvum. Therefore, we evaluated its antimalarial effects on Plasmodium falciparum and Plasmodium berghei. In vitro, chloroquine (CQ)-sensitive and resistant strains of P. falciparum parasitized red blood cells were incubated with escalating doses of alpha-epi-Br or CQ. In vivo, 62 rats were infected with P. berghei and treated with CQ or alpha-epi-Br. At the highest doses tested against a CQ-sensitive strain, parasitemias decreased from 25.4% in the saline control group to 4.3% and 4.8% in the alpha-epi-Br and CQ groups, respectively (P < 0.05). Against two CQ-resistant strains, parasitemias decreased from 22.3-28.8% and 24.8-30% in the CQ and saline groups, respectively, to 2.5-2.7% in the alpha-epi-Br groups (P = 0.003). In vivo, on Day 4, parasitemias decreased from 23% in the saline group to 9-12% and 12% in the in alpha-epi-Br and CQ groups, respectively (P < 0.05). These data demonstrate that alpha-epi-Br shows activity against CQ-sensitive and resistant strains of P. falciparum in vitro. At the doses tested against P. berghei in vivo in rats, alpha-epi-Br is comparable to CQ.  (+info)

Familial resemblance for free androgens and androgen glucuronides in sedentary black and white individuals: the HERITAGE Family Study. Health, Risk Factors, Exercise Training and Genetics. (8/160)

Familial correlation analyses were used to evaluate the familial aggregation of plasma androgens and androgen glucuronides (testosterone (TESTO), dihydrotestosterone (DHT), androstane-3 alpha,17 beta-diol glucuronide (3 alpha-DIOL-G), and androsterone glucuronide (ADT-G)) in 505 members of 99 white families and 296 members of 111 black families participating in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study. Each of these four measures was determined by RIA after separation of conjugated and unconjugated steroid using C18 column chromatography. All participants were sedentary prior to being including in this study. Significant spouse correlations, as well as parent-offspring and sibling correlations, were found for TESTO, DHT, 3 alpha-DIOL-G, and ADT-G in the white sample, suggesting that common familial environments and genes contribute to the familial resemblance. In the black sample, significant sibling and parent-offspring correlations were found for all four phenotypes, while the spouse correlation was marginally significant for 3 alpha-DIOL-G and not significant for TESTO, DHT, and ADT-G. The non-significance of spouse correlations in the black individuals may be due to the small number of spouse pairs. The maximal heritability estimates of TESTO, DHT, 3 alpha-DIOL-G, and ADT-G were 69%, 87%, 74%, and 56% for white individuals and 70%, 73%, 62%, and 48% for black individuals respectively. Sex differences in heritability estimates were found in the white individuals, but they were less dramatic in the black individuals. In conclusion, plasma levels of androgens and androgen glucuronides are highly heritable in both white individuals and black individuals. There are notable sex differences in the white individuals.  (+info)

*Biological passport

... androsterone, and etiocholanolone. The World Anti-Doping Agency recently released the 2014 Prohibited Substances list and it ...

*Etiocholanolone

... , also known as 5β-androsterone, as well as 3α-hydroxy-5β-androstan-17-one or etiocholan-3α-ol-17-one, is an ... Etiocholanolone glucuronide Epietiocholanolone Androsterone Epiandrosterone Reddy DS (2010). "Neurosteroids: endogenous role in ... Kaminski RM, Marini H, Kim WJ, Rogawski MA (June 2005). "Anticonvulsant activity of androsterone and etiocholanolone". ... "Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural ...

*Androsterone

... is sulfated into androsterone sulfate and glucuronidated into androsterone glucuronide and these conjugates are ... Androsterone has been shown to naturally occur in pine pollen and is well known in many animal species. Androsterone was first ... Androsterone has been found to affect human behavior when smelled. Androsterone and its 5β-isomer, etiocholanolone, are ... Androsterone is found in the human axilla and skin as well as in the urine. It may also be secreted by human sebaceous glands. ...

*Androsterone glucuronide

... (ADT-G) is a major circulating and urinary metabolite of testosterone and dihydrotestosterone (DHT). ... ADT-G is formed from androsterone by UDP-glucuronosyltransferases, with the major enzymes being UGT2B15 and UGT2B17. It is a ... 837-. ISBN 978-1-4557-2758-2. Metabocard for Androsterone Glucuronide (HMDB02829) - Human Metabolome Database. ... Androsterone sulfate Etiocholanolone glucuronide 3α-Androstanediol http://www.hmdb.ca/metabolites/HMDB02829 Jerome F. Strauss, ...

*Androsterone sulfate

... , also known as 3α-hydroxy-5α-androstan-17-one 3α-sulfate, is an endogenous, naturally occurring steroid ... Androsterone glucuronide Steroid sulfate Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA (2015). "The Regulation of ... It is a steroid sulfate which is formed from sulfation of androsterone by the steroid sulfotransferase SULT2A1 and can be ... http://www.hmdb.ca/metabolites/HMDB02759 Metabocard for Androsterone Sulfate (HMDB02759) - Human Metabolome Database. ...

*1-Androsterone

... (also known as 1-andro, 1-dehydroepiandrosterone, 1-DHEA, δ1-epiandrosterone, or 5α-androst-1-en-3β-ol-17-one) ... "1-Androsterone": identification as 3β-hydroxy-5α-androst-1-en-17-one and its urinary elimination". Steroids. 76 (6): 540-7. doi ... 4-Dehydroepiandrosterone Androsterone Epiandrosterone Parr MK, Opfermann G, Geyer H, Westphal F, Sönnichsen FD, Zapp J, ...

*Steroid sulfotransferase

Androsterone (to androsterone sulfate); Pregnenolone (to pregnenolone sulfate) SULT2B1a: Pregnenolone (to pregnenolone sulfate ...

*Dehydroepiandrosterone (disambiguation)

1-androsterone) Androstenediol Androstenedione Androstenolone. ...

*Timeline of biology and organic chemistry

1931 - Adolf Butenandt discovered androsterone. 1932 - Hans Adolf Krebs discovered the urea cycle. 1933 - Tadeus Reichstein ...

*5β-Dihydrotestosterone

Kaminski RM, Marini H, Kim WJ, Rogawski MA (June 2005). "Anticonvulsant activity of androsterone and etiocholanolone". ... 3α-Androstanediol 3β-Androstanediol Androsterone Epiandrosterone Hormones, Brain and Behavior Online. Academic Press. 18 June ...

*List of neurosteroids

Kaminski RM, Marini H, Kim WJ, Rogawski MA (2005). "Anticonvulsant activity of androsterone and etiocholanolone". Epilepsia. 46 ... 5α-androst-16-en-3-one Androsterone: 5α-androstan-3α-ol-17-one Estratetraenol: estra-1,3,5(10),16-tetraen-3-ol 4-Androstadienol ... GABAA receptor positive allosteric modulator Androsterone: 5α-androstan-3α-ol-17-one - GABAA receptor positive allosteric ...

*16-Androstene

Androstane Androsterone Estratetraenol Gower, D. B.; Ruparelia, B. A. (1993). "Olfaction in humans with special reference to ...

*UFC 183

Silva's team was unable to explain the presence of androsterone in the Jan. 9 test. The commission rejected the defense and ... Silva also had traces of androsterone, a form of endogenous testosterone and also another banned substance. Silva was also ... overturned after he tested positive for drostanolone and androsterone. Diaz also tested positive for marijuana. The following ...

*Testosterone (medication)

It is excreted mainly as androsterone glucuronide and etiocholanolone glucuronide. It is also excreted to a small extent as ... The major urinary metabolites of testosterone are androsterone glucuronide and etiocholanolone glucuronide. The elimination ...

*List of androgens/anabolic steroids (alternate)

Androsterone Bolandione (19-nor-4-androstenedione)* Dehydroandrosterone (DHA; 5-dehydroandrosterone) Epiandrosterone * Only ...

*Briken Calja

In 2013 Calja was suspended for two years for using androsterone. London 2012 Archived 2012-08-01 at the Wayback Machine. "Rio ...

*3α-Androstanediol

Androsterone Androstenol Etiocholanolone Androstanediol glucuronide Membrane androgen receptor Reddy DS (2010). "Neurosteroids ...

*Dehydroepiandrosterone

Some isomers of DHEA are 1-dehydroepiandrosterone (1-androsterone) and 4-dehydroepiandrosterone. These isomers are also ...

*Athletics at the 2005 National Games of China

The result did not stand, however, as Sun failed a drugs test for androsterone. Her test at the Beijing Marathon the previous ...

*Etiocholanolone glucuronide

Along with androsterone glucuronide, it is one of the major inactive metabolites of testosterone. 3α,5β-Androstanediol 5β- ...

*Androstanediol glucuronide

3β-Androstanediol Androsterone glucuronide Etiocholanolone glucuronide Moghissi E, Ablan F, Horton R (September 1984). "Origin ...

*Concerns and controversies at the 2014 Asian Games

Iraqi weightlifter Mohammed al Aifuri tested for positive for etiocholanolone and androsterone. It was his second failed drug ...

*19-Norandrosterone

Androsterone 19-Noretiocholanolone 5α-Dihydronandrolone 5α-Dihydronorethisterone "THE 2007 PROHIBITED LIST INTERNATIONAL ...

*Pheromone

... and androsterone. Androstenol is the putative female pheromone. In a 1978 study by Kirk-Smith, people wearing surgical masks ...

*Mary Ellen Jones (chemist)

add NAE ref]. She pursued these interests by studying androsterone and monopalmitin at Armour, and cathepsin C at Yale. Jones ... Their research led to Munson and Jones publishing two papers on androsterone and monopalmitin in the Journal of Biological ...
Product Description Product Description Factory Supply Prohormone Steroid Powder Epiandrosterone CAS 481-29-8 Epiandrosterone CAS: 481-29-8 Epiandrosterone MF: C19H30O2 Epiandrosterone MW: 290.44 Epiandrosterone EINECS: 207-563-3 Epiandrosterone Purity: 99%min Epiandrosterone Appearance: White crystalline powder Epiandrosterone Standard: USP/BP/EP/Enterprise Standard Epiandrosterone Usage: Anabolic steroid; A steroid hormone that is present in normal human urine as a minor constituent , it is a less…
Epiandrosterone is a prohormone that is completely legal and available over the counter. It may also appear under the name 3b-hydroxy-etioallocholan-17-one. Epiandrosterone is a precursor to Stanolone, a powerful steroid hormone. Epiandrosterone can be found naturally occuring in most mammals and is excreted in urine as a normal part of human metabolism. One of the reasons that this prohormone is legal because it has been found to be naturally occurring in pine pollen. Epiandrosterone and Androsterone are very closely related. Androsterone is the 3-alpha isomer and epiandrosterone is the 3-beta isomer of this compound. The actions of the two isomers in the body are different, but still very similar. Most epiandrosterone supplements are actually a mix of the two isomers, meaning that they contain some androsterone as well as the main ingredient epiandrosterone ...
Epiandrosterone acetate 1239-31-2 route of synthesis, Epiandrosterone acetate chemical synthesis methods, Epiandrosterone acetate synthetic routes ect.
Epiandrosterone acetate 1239-31-2 MSDS report, Epiandrosterone acetate MSDS safety technical specifications search, Epiandrosterone acetate safety information specifications ect.
China White Crystalline Muscle Building Steroids Powder Androsterone 53-41-8, Find details about China Androsterone, Male Hormone from White Crystalline Muscle Building Steroids Powder Androsterone 53-41-8 - Wuhan Lianshangwang Technology Co., Ltd.
China Purity 98% Androsterone CAS No.: 53-41-8, Find details about China Androsterone, CAS No.: 53-41-8 from Purity 98% Androsterone CAS No.: 53-41-8 - Shenzhen Simeiquan Biotechnology Co., Ltd.
... 1-Androsterone, prohormone, 1-DHEA1-androsterone (aka 1-DHEA) is a prohormone that undergoes a two step conversion through the enzy
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Super-Rb DHEA is 3-beta-undecanoyloxy-5-alpha-androstan-17-one which is more commonly knonwn as Epiandrosterone. Epiandrosterone and Androsterone (sometimes referred to as R-DHEA) are almost identical in structure, with Epiandrosterone being the 3-beta isomer (thus why it may also be referred to as Isoandrosterone) and Androsterone being the 3-alpha isomer. It is a naturally produced metabolite of the adrenal hormone Dehydroepiandrosterone (DHEA) by the enzyme 5a-reductase.. DHT also functions as an antagonist of estrogen which may cause gynecomastia in some men by reducing DHT levels in the body, and thus reducing DHTs antagonism of estrogen in the body. DHT directly inhibits estrogens activity on tissues, either by acting as a competitive antagonist to the estrogen receptor or by decreasing estrogen-induced RNA transcription at a point subsequent to estrogen receptor binding. It also directly blocks the production of estrogens from androgens by inhibiting the activity of aromatase. Studies ...
By Patrick Arnold "Steroids" is a prestigious journal that covers the science of….take a guess…steroids. An abstract has just recently been released http://www.ncbi.nlm.nih.gov/pubmed/21310167 for an article that is soon to be published in Steroids. The article concerns the product 1-Androsterone by Advanced Muscle Science (AMS). It explains how this product was seized by some German FBI type agency and then sent to a lab to be analyzed for both capsule content and in-vivo metabolism. I am sure this was a major bust for the neo-gestapo over there. I mean its not like you can just openly buy this stuff over dozens of websites.. Anyway, the study did find that the product contained the proper amount of the proper compound (which BTW is technically 1-DHEA and not 1-androsterone). Kudos to AMS for that at least, since so many hormonal products on the market are mislabeled and under dosed. The study also showed that ingestion of the product caused an increase in urinary excretion of ...
Product Description Product Description Sex Hormone Powder Androgen 1- DHEA /1-Androsterone Safe Shipping Quick details 1-DHEA / 1-Androsterone Alias:Androsta-1-ene-3b-ol,17-one;Androstene-3b-ol,17-one;1-Dehydropiandrosterone CAS register number:76822-24-7 Assay:99% EINECS No.:76822-24-7 Appearance: white or off white crystalline powder Related Substances: Pharmaceutical Grade Storage: Shading, confined preservation Description: Items Tested Specification Result Characters White or almost white crystalline powder Confirms Assay (HPLC) 99.0--101.0%…
Dehydroepiandrostenedione (more correctly didehydroepiandrosterone), also known as androstenolone or prasterone, as well as 3β-hydroxyandrost-5-en-17-one or 5-androsten-3β-ol-17-one, is an important endogenous steroid hormone. It is the most abundant circulating steroid hormone in humans, in whom it is produced in the adrenal glands, the gonads, and the brain, [4] where it functions predominantly as a metabolic intermediate in the biosynthesis of the androgen and estrogen *** steroids. However, Dehydroisoandrosterone also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a neurosteroid. Dehydroisoandrosterone Usage ...
Alternative (backdoor) androgen production and masculinization in the human fetus{{#pmid:30763313,PMID30763313}} Masculinization of the external genitalia in humans is dependent on formation of 5α-dihydrotestosterone (DHT) through both the canonical androgenic pathway and an alternative (backdoor) pathway. The fetal testes are essential for canonical androgen production, but little is known about the synthesis of backdoor androgens, despite their known critical role in masculinization. ...Results show that androsterone is the principal backdoor androgen in the male fetal circulation and that DHT is undetectable (,1 ng/mL), while in female fetuses, there are significantly lower levels of androsterone and testosterone. In the male, intermediates in the backdoor pathway are found primarily in the placenta and fetal liver, with significant androsterone levels also in the fetal adrenal. Backdoor intermediates, including androsterone, are only present at very low levels in the fetal testes. This ...
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pheromonesLove Scent Pheromone - What are Androsterone Pheromones?Once the only form of communication between animals, pheromones are chemical messengers from one being to another that affect the behavior of the receiver. From ...
1903-1995) German organic chemist and biochemist. Butenandt, who was born at Bremerhaven-Lehe (now Wesermünde) in Germany, took his first degree in chemistry at the University of Marburg and gained his doctorate in 1927 under Adolf Windaus at Göttingen. He remained at Göttingen as Privatdozent until 1933. Following the work of Windaus on cholesterol, Butenandt investigated the sex hormones and in 1929 he isolated the first pure sex hormone, estrone, from the urine of pregnant women (the compound was also discovered independently by Edward Doisy). A search for the male sex hormone resulted in the isolation in 1931 of 15 milligrams of androsterone from 3960 gallons of urine.. In 1933 he became professor of organic chemistry at the Danzig Institute of Technology and here he demonstrated the similarities between the molecular structures of androsterone and cholesterol. His proposed structure for androsterone was confirmed by Leopold Ružičkas synthesis in 1934. The male hormone testosterone was ...
Androsterone then again is a masculine pheromone that lacks the aggressive vibe produced by androstenone. From here signals are despatched by neurons (nerves) to the accent olfactory bulbs, which is the part of the brain liable for processing the data relayed by the pheromones and mediating a response. Curiously, essentially the most considerable pheromone on the market is androstenone , but this pheromone has been shown to don`t have any motion within the VNO. It picks up scents that aren`t normally detected, ones that carry an excessive amount of details about an individual. It might therefore be doable to tailor a pheromone combine specifically for an individual, in essence creating the impression of a great companion, but in the meanwhile that is beyond current know-how. You`ll find a lot of web sites which have information about the science of scent attraction ...
1) ,endocrinology, A male sex hormone, derived from progesterone, which is seven times weaker than testosterone. It is found in the plasma and urine of both men and women. Formula: C19H30O2. (2) A steroid hormone excreted in urine that reinforces masculine characteristics ...
High Purity 7-Keto-Dehydroepiandrosterone for Weight Loss CAS 566-19-8 7-Keto-DHEA Basic Info: Model NO.: 1-DHEA Customized: Non-Customized Suitable for: Elderly, Adult Purity: |99% 1-Androsterone Alias: 1-DHEA 1-Androsterone Formula: C19h28o2...
Matrix metalloproteinases (MMPs) are a family of Zinc- dependent endopeptidases that degrade extracellular matrix proteins. MMP-9 serum is quantitated using an ELISA (Enzyme Linked Immunosorbent Assay) procedure. It is a two-step sandwich-type immunoassay using two antibodies to MMP-9 Learn more.
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The rabbit aortic strip preparation of Furchgott was used to test the effect of adrenal steroids upon the muscle contraction produced by 0.1 to 0.2 µg. of levarterenol. The steroids tested were corticosterone, hydrocortisone, aldosterone acetate, androsterone, and dehydroisoandrosterone. Amounts of 1 to 300 µg. were added to the 20-ml. muscle bath. Potentiation was produced by each steroid; the percentage increase of amplitude of contraction was from 36.1 to 74.2 percent. Corticosterone produced consistent potentiation in amounts as small as 5 µg.; 200 µg. of aldosterone acetate was required to produce potentiation. Maximum potentiation was produced by hydrocortisone. The observed potentiation may be due to an effect of adrenal steroids upon transcellular sodium and potassium gradients.. ...
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LURE-Wangian Pemikat Wanita (for him) Mengandungi bahan pheromone sintetik bernama Androstenone, 5-alpha-an-drost-16-ene-one, androstenol, androsterone, estrat
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Phero-Max mengandungi bahan pheromone sintetik bernama Androstenone, 5-alpha-an-drost-16-ene-one, androstenol, androsterone, estratetraenol dan androstadienone
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Although testosterone was not isolated until 1935, four years after its metabolite androsterone, the basic origins and effects of the substance have been known for a much longer period of time.
Although androsterone and dehydroandrosterone, two substances of androgenic character, have been separated from human urine, very little is known as to the significance of their occurrence and still less as to the fluctuations in the rate of excretion in health and disease. It is generally assumed that these substances are waste products formed from testosterone secreted into the blood stream by the gonads, but it is just as reasonable to expect that one or both of these urinary products may be precursors of testosterone or that they, or still other androgenic substances, may originate in part in other tissues or ...
... with 4-Androsterone: A compound that is also known as 4-DHEA and is a DHEA derivative, this compound converts into the master hormone, testosterone. Testosterone is both anabolic and androgenic, meaning
Application of androgen (testosterone or androsterone) delayed the barrier recovery, and the delay was overcome by co-application of β-estradiol. Progesterone also delayed the barrier recovery, but in this case the delay was enhanced by β-estradiol. Conclusions ...
Androsterone Pheromone Concentrate, What are the MostPheromones have left the arena of little-known biological chemicals and entered the realm of topics that ca
Androsterone Reviews - Is He Straight Into You?Probably the most is it the real thing or is it a scam? are they the same? could start with extremely little chemistry at all. ...
Etiocholanolone, also known as 5β-androsterone, as well as 3α-hydroxy-5β-androstan-17-one or etiocholan-3α-ol-17-one, is an etiocholane (5β-androstane) steroid as well as an endogenous 17-ketosteroid that is produced from the metabolism of testosterone. It causes fever, immunostimulation, and leukocytosis, and is used to evaluate adrenal cortex function, bone marrow performance, and in neoplastic disease to stimulate the immune system. Etiocholanolone is also known to be an inhibitory androstane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor, and possesses anticonvulsant effects. The unnatural enantiomer of etiocholanolone is more potent as a positive allosteric modulator of GABAA receptors and as an anticonvulsant than the natural form. Etiocholanolone is produced from 5β-dihydrotestosterone, with 3α,5β-androstanediol as an intermediate. Etiocholanolone glucuronide Epietiocholanolone Androsterone Epiandrosterone Reddy DS (2010). "Neurosteroids: endogenous ...
To the Editor: In the December 1967 issue of the ANNALS, statement on p. 1291 (1) that the syndrome of etiocholanolone fever "has been widely accepted" was supported by reference to one textbook of medicine (2) but not to another (3). In both books, the subject is discussed and related to periodic fever and to periodic peritonitis. Etiocholanolone fever as such may exist, but its connection with febrile periodic disorders is unproved, to say the least. Bondy, who first proposed a relation, later questioned whether increase in the amount of etiocholanolone causes the fever in periodic disorders, is an incidental ...
Human pheromones are said to increase sex drive and many products claim to have an aphrodisiac property that will help to promote a higher libido and attract members of the opposite sex. There are four main molecules that make up most pheromone colognes and over the counter products. These include androstenone, androsterone, androstadienone and androstenol. The different molecules work in different ways to achieve their desired effects. Sexual products for instance that contain higher levels of androstenone tend to work better as attractants for the opposite sex.. Androstenone - Of the four basic molecules, androstenone contains the most potent molecules regarding sexual attraction. This particular pheromone can increase sexual desire in women and can help men to be more attractive to women looking for a potential mate or sexual partner.. Androsterone - Those products that contain androsterone help to make wearers seem more trustworthy and appear more masculine.. Androstadienone - Products that ...
Androsterone can be worn by women, though the effects of the pheromone are not as strong when women wear it. Men will usually experience an elevated mood when detecting this pheromone on a woman. Androsterone is usually mixed with other pheromones in order to enhance the effectiveness of the other chemicals, as it acts as a subtle boost to the other pheromones that will make them and it more effective. There are no effects resulting from too much androsterone, making it one of the best and strongest pheromones. ...
Proliferation assessed by determination of expression levels of proteins involved in cell cycle progression, cyclin D3, and cyclin-dependent kinase 4 (CDK4) with Western blot analysis, and determination of DNA synthesis with bromodeoxyuridine (BrdU) incorporation assay; activation of AMPK, Erk1/2, and S6K1 determined by Western blot analysis with the use of antibodies specific for the phosphorylated (activated) forms.. Result(s): ...
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B2 acts on various endogenous steroids, especially etiocholanolone and androsterone.
We synthesized two series of androstane derivatives as inhibitors of type 3 and type 5 17β-hydroxysteroid dehydrogenases (17β-HSDs). In the first series, four monospiro derivatives at position C17 were prepared from androsterone (ADT) or epi-ADT. After the protection of the alcohol at C3, the C17-ketone was alkylated with the lithium acetylide of tetrahydro-2-(but-3-ynyl)-2-H-pyran, the triple bond was hydrogenated, the protecting groups hydrolysed and the alcohols oxidized to give the corresponding 3-keto-17-spiro-lactone derivative. The other three compounds were generated from this keto-lactone by reducing the ketone at C3, or by introducing one or two methyl groups. In the second series, two dispiro derivatives at C3 and C17 were prepared from epi-ADT. After introducing a spiro-δ-lactone at C17 and an oxirane at C3, an aminolysis of the oxirane with L-isoleucine methyl ester provided an amino alcohol, which was treated with triphosgene or sodium methylate to afford a carbamate- or a morpholinone
Ive never had success with women and Ive struck out more times than I can count. Its not that Im nervous to approach them, its just that I have a hard time closing the deal, if you know what I mean. I heard from a buddy of mine about a pheromone called Alpha 7 Unscented. Ive seen pheromones advertised before but I never knew if they actually worked or not. But since my buddy recommended it, I decided to give Alpha 7 a try. I decided to try it out at the new club that just opened up downtown.. What Is It?. The Alpha 7 Unscented arrived in a small vial in a plain box. I still had time before I was going to head to the club, so I decided to get on Google to research it. I found out that Alpha 7 unscented is an andro heavy pheromone that contains 40% more pheromone than competing pheromone products except top brands like Pherazone. The mixture is comprised of 6mg of Androstenone and 1mg of Androsterone.. How Does It Work?. But what does all of that mean? Well, apparently, Alpha 7 is pretty ...
According to some Chikara review, the cologne is actually a mixture of three essential pheromones, particularly androsterone, androstenone, and androstenol in addition to other ingredients. This is the reason behind its success since the vomeronasal organ can detect them, making the wearer appear sexually attractive to the opposite sex. This organ picks up the pheromone and carries it to the hypothalamus that in flip, sends signals to the brain. An individual carrying Chikara is made extra attractive the opposite sex so his chances of getting a good associate enhance - that is principally how Chikara works. The pheromone that is being released is actually way superior than those that are being produced from the body so an individual can get to become more appealing to different people particularly to the opposite sex ...
In the Your Amazing Brain exhibition in Bristol, UK, weve tested our visitors with a pheromone called androstenone. This pheromone is produced by men and is now sold over the internet as date-mate - a spray which guarantees to make you irresistible to women.. Thousands of our visitors have given their opinion on androstenone. This is what they said:. ...
Hormone Regulation Kit 1-Andro + 4-AD + Arom-X + 1-Androsterone Remember when Prohormones worked as advertised without harsh side effects or dangers?
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.‎Melatonin and Xanax Drug · ‎Aspirin Low Strength and · ‎Benadryl · ‎Tylenol. Learn about drug interactions between loratadine-pseudoephedrine oral and melatonin sl and use the RxList drug interaction checker to check drug combinations. Allergy-Congestion Relief-D Oral, Claritin-D 12 Hour Oral, Claritin-D 24 Hour Oral, Clear-Atadine-D Oral, Lorata-D Oral, lorata-dine D Oral, Loratadine-D Oral. My androsterone told me to take a Claritin befor bed. Epoxy 4, , cuztomize.info "My escort told me to take a Claritin befor can you take claritin and melatonin together.. ...
Mens apocrine glands are better than womens, and they stash more aggressively during time of excitement. Men stash more androsterone than women do, and ironically most men are powerless to reveal the things they are producing. Intesupportingly, women have a fierce, convinced and kind outcome to the smell of androsterone pheromone around ovulation, when their intuit of smell becomes more precision and when they are most probable to conceive. This may be perhaps due to changes in their bodies hormonal equals around ovulation. Women choose the smell of those men whose genetically hinted immunities are different from their own. Supporting prove for the life of individual-explicit bouquet comes from studies in which mothers have identified their own child infants from the smell of a previously shabby T-shirt ...
One of the greatest and most common myths is that human pheromone products do not work and are scams. Unfortunately, this myth does present with a small degree of truth as there are numerous products such as Nexus Pheromones claiming to have human pheromones as an ingredient when they do not. As a result of this, the product will not work as necessary. This is one method to scam people out of their money as individuals will pay a large amount to purchase items with human pheromones included in the product.. Methods to avoid being scammed are to increase knowledge of what has and does not have human pheromones as an ingredient. The three primary pheromone substances include androstenone, androstenol, and androsterone. If a product claims to, and actually does, contain one of these compounds it will operate as required of pheromones. However, to ensure the product contains the item it is necessary to check the product ingredients before each purchase.. ...
For when you just cant get enough...If you want to inspire endless hunger then try our amazing alchemy of all the drool-worthy lust-inspiring scents women love on male flesh...But the sexy secret is our exclusive WANTED MAN pheromone mix, the bad boy blend of Androsterone and Androstenone wome
Albert Eschenmoser (born August 5, 1925) is a Swiss organic chemist best known for his work on the synthesis of complex heterocyclic natural compounds, most notably vitamin B12. In addition to his significant contributions to the field of organic synthesis, Eschenmoser pioneered work in the Origins of Life (OoL) field with work on the synthetic pathways of artificial nucleic acids. Before retiring in 2009, Eschenmoser held tenured teaching positions at the ETH Zurich and The Skaggs Institute for Chemical Biology at The Scripps Research Institute in La Jolla, California as well as visiting professorships at the University of Chicago, Cambridge University, and Harvard. Eschenmoser began his scientific career as a graduate student in the laboratory of Leopold Ružička, at the Eidgenossische Technische Hochschule (ETH) in Zurich. Ruzicka was a notable organic chemist himself having been awarded the Nobel Prize in Chemistry in 1939 for his work on the synthesis of androsterone and testosterone. ...
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Vertebrate females produce their full complement of oocytes during embryogenesis and, over time, these are either released (and fertilized or not) or undergo cell death. Oocyte death ultimately leads to sterility as the animals age and conditions that accelerate death of the eggs cause premature infertility. Nutt et al. used unfertilized Xenopus eggs and egg extracts that recapitulate many of the cell death events to investigate the molecular mechanisms that control oocyte survival. Caspase-2 was known to regulate mouse oocyte survival, and Nutt et al. show that caspase-2 activity is inhibited in Xenopus oocytes by NADPH, which is produced as a by-product of metabolic flux through the pentose-phosphate pathway. Addition of glucose-6-phosphate (G6P) or other intermediates in the pentose-phosphate pathway, but not the glycolytic pathway, inhibited activation of caspase-2 and caspase-3, cytochrome c release, and oocyte cell death. Inhibition of G6P dehydrogenase by dehydroisoandrosterone (DHEA), ...
Celery - yes, I actually mean celery as in what you probably have in your frig right now. Its so common you wouldnt normally associate it with the food of Gods but in fact, with Celery there is more than meets the eye as it is known to contain androstenone - which is a steroid that when given to female animals in heat, have been known to make them more sexually aggressive. Some suggest that female humans may have the asme result. Also in humans androstenone is used as a pheromone.. ...
The average nose size for adult males is 5.8 centimeters and for adult females is 5.1 centimeters. The width of the human nose usually increases with age. Mens noses grow larger than womens...
Hormonal 6 Epsilon -lower alkanoylthio-3-oxo-4-en-steroids are prepared from corresponding 6 Epsilon -halo-3-oxo-delta-4steroids and 6 Epsilon -lower alkanoylthio-5-hydroxy-3-oxosteroids. They are also useful as intermediates for synthesis of hormonal thieno-(4,3,2-4,5,6,)steroids which have been disclosed in U.S. Pat. No. 3,300,485.
GenBank) porD pyruvate synthase subunit porD (EC 1.2.7.1) (pyruvate oxidoreductase delta chain) (pyruvate ferredoxin oxidoreductase ...
Identification of etiocholanolone as the primary metabolite of testosterone has important implications for understanding the potential embryonic effects of yolk testosterone. Etiocholanolone has been shown to be a potent stimulator of erythropoiesis in mammals [34] and birds [35,36]. The potency of etiocholanolone is closely related to its 5β configuration, as several 5β androgens and 5β pregnanes stimulate erythropoiesis, while their respective 5α epimers are much less potent [35,37]. The conversion of yolk testosterone, and presumably androstenedione, to etiocholanolone may function to stimulate the production of erythrocytes early in development. Chick blastoderms increase erythropoiesis in response to exogenous etiocholanolone [36], and data from the present study suggest that yolk testosterone may serve as an endogenous precursor for etiocholanolone production. The idea that erythropoiesis may be increased in response to increased yolk androgens is consistent with existing data, which ...
Primary cultures of stromal-vascular (S-V) cells from adipose tissue were used to investigate the regulation of preadipocyte development. Differentiation of S-V cells was found to be under hormonal control. Insulin and glucocorticoids are essential for S-V cell differentiation in culture. S-V cells from both newborn and mature pig adipose tissue and sera from both ages were used to examine the effect of age on preadipocyte development. S-V cells from newborn pigs replicated faster and appeared more responsive to serum borne factors influencing S-V cell growth and development in culture. Serum source (newborn vs mature) did not affect differentiation of S-V cells from newborn or mature pig adipose tissue. When sera from fed or fasted pigs were used to culture newborn pig S-V cells, fasted pig sera stimulated greater differentiation and decreased cell replication as indicated by DNA content of rat S-V cell culture. Lean pig serum compared to obese pig serum, increased differentiation activity in ...
Results of recent studies have demonstrated that genetic variants of the enzyme steroid 5 reductase type II (SRD5A2) are associated with serum concentrations of major androgen metabolites such as conjugates of androstane-3,17β-diol-glucuronide (3-diol-G). However, this association was not consistently found among different ethnic groups. Thus, we aimed to determine whether the association with SRD5A2 genetic variations exists in a cohort of healthy Chinese elderly men, by examining 2 metabolite conjugates: androstane-3,l7β-diol-3-glucuronide (3-diol-3G) and androstane-3,17β-diol-17-glucuronide (3-diol-17G).. ...
Pork from organic pigs that are not soiled in manure and that have a reduced live weight at slaughter has a reduced risk of boar taint.
US - A US Department of Animal Sciences study has shown that repeated exposure to boar taint makes people more susceptible and aware of the smell.
16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one: a synthetic adrenal hormone that reduced the incidence of tuberculosis and other opportunistic infections in AIDS patients
Study by Ewert G. in which he observed the duration it took tracers to travel 2mm that were placed inside the human nose at varying levels of air humidity.
Study by Ewert G. in which he observed the duration it took tracers to travel 2mm that were placed inside the human nose at varying levels of air humidity.
Buy Nexus Pheromones DISCOUNT on Selected Package, CLICK HERE!. Nexus is really a pheromone item which has a great deal of hype surrounding it and it is really a item which has been on the market for some time. According towards the manufacturer, Nexus includes pure androstenone pheromone concentrate, which may be the active ingredient that is supposed to help men attract women. The product comes in a full one ounce bottle and is to be applied to pulse points. The company also offers a money back guarantee for those who are not satisfied with the item.. Item Description. Nexus Phermone spray is precisely what you should attract and excite ladies. Nexus works immediately and without anybody elses knowledge. Simply utilize the spray and you will immediately start radiating sexiness! Youll immediately notice which you have an increased sex appeal, much more eye contact, smiles, and interest from the opposite sex, a restoration of the existing relationship, much more lovemaking, a soothing, ...
Buy Nexus Pheromones DISCOUNT on Selected Package, CLICK HERE!. Nexus is really a pheromone item which has a great deal of hype surrounding it and it is really a item which has been on the market for some time. According towards the manufacturer, Nexus includes pure androstenone pheromone concentrate, which may be the active ingredient that is supposed to help men attract women. The product comes in a full one ounce bottle and is to be applied to pulse points. The company also offers a money back guarantee for those who are not satisfied with the item.. Item Description. Nexus Phermone spray is precisely what you should attract and excite ladies. Nexus works immediately and without anybody elses knowledge. Simply utilize the spray and you will immediately start radiating sexiness! Youll immediately notice which you have an increased sex appeal, much more eye contact, smiles, and interest from the opposite sex, a restoration of the existing relationship, much more lovemaking, a soothing, ...
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Bad timing is the most common reason for women seeking abortions at Royal Womens Hospital, the first report on women using its pregnancy advisory service finds.
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Western-blot analysis using antiserum to 3T3-L1-cell fatty acid binding protein (FABP) revealed that pig adipose tissue contains a 15 kDa protein immunologically similar to the murine protein. This 15 kDa protein was purified from pig adipose tissue by sequential application of Sephadex G-50 gel filtration, cation exchange and covalent chromatography on Thiol-Sepharose-4B. The purity of the pig protein was established by two-dimensional polyacrylamide-gel electrophoresis. Isoelectric focusing indicated that the pig adipose FABP (a-FABP) exists with two charge isoforms (pI 5.1 and 5.2), both of which persist after delipidation. The N-terminus of the purified pig a-FABP was blocked; however, cleavage with CNBr allowed recovery of a 12-amino-acid peptide which was identical with the murine a-FABP sequence (residues 36-48) at 10 of 12 positions. The pig a-FABP bound 12-(9-anthroyloxy)oleic acid saturably and stoichiometrically, with an apparent dissociation constant of 1.0 microM. Northern-blot ...
Pure Temptation for Women contains trace quantities of Androstenone to help create a vibe of a sexually confident woman. Women naturally produce copulins (female pheromones) when ovulating that makes them desirable, irresistible to men - a pure temptation. This pheromone is intended to mimic this sexually-charged time in a womans cycle to create an air of enchantment that is unmistakable to men. Make it impossible for him to take his eyes off you at the next event where youre destined to meet - with Pure Temptation. You may find it drives him wild with passion and set the stage for a night full of seduction and spice. See our full line of pheromones for women. Our premium pheromones are designed to provide the extra confidence you need in any situation - whether its a business meeting or blind date. You can choose from our pheromone products to help achieve your desired outcome - whether you want to boost your success in the boardroom, or the bedroom, impress the woman of your dreams or get a ...
This investigation aimed to establish noninvasive methods for endocrine monitoring of estrous cycles and pregnancy in the Indian rhinoceros. Fecal samples were collected 1-3 times per week from nonpregnant and pregnant captive females (n = 7). Enzyme
The purpose of this paper is to reduce boar taint, degrade one of the substances that caused boar taint-skatole by processing, so skatole blend of organic solution was selected as test material in vit
THE NETHERLANDS - With regulations ahead restricting castration of male pigs in a number of countries, Hypor is working on the selection of boars with a reduced incidence of boar taint.
Surgical castration of piglets is a common practice in farms to avoid boar taint (androstenone and skatole) in meat, and to improve its sensory quality. The European Commission is planning to ban surgical castration by ...
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Posted by Philip Dru on 4/19/09 U.S. manufacturers, including major drugmakers, have legally released at least 271 million pounds of pharmaceuticals into
Robert Biggum Henderson, a convicted drug dealer and admitted junkie, says he has lived most of his life by the law of the streets. Dont snitch. I dont talk about...
Wearing a pheromone cologne instills a breeze of confidence in the person wearing the cologne. However, it is also not good to be able to have too much confidence in you. Dont you ever think that if you walk in the middle of the lime light, in the midst of a beautiful and handsome crowd, people will notice you instantly. The main function of a pheromone cologne is actually to help you have a sense of confidence in you. It will help you feel good about yourself and create an impression that you are an attractive person. Once you get the heat, continue to create a good impression and let them notice you and eventually get attracted to you. Mingle in the event that you must. Have conversations with different kind of people and get those pheromones going ...
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Page: 593. M. Okrouhláa, R. Stupkaa, J. Číteka, D. Urbanováa, K. Vehovskýa, and L. Kouřimskáb a Department of Animal Husbandry, b Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Prague, Czech Republic Keywords: boar taint, androstenone, skatole, indole, high performance liquid chromatography method, back fat Summary Full text (PDF) ...
1OHS: Crystal Structure of 5-3-Ketosteroid Isomerase Mutant Y14F/D38N from Pseudomonas Testosteroni Complexed with Androstanedione
Barbaccia M. L., Lello S., Sidiropoulou T., Cocco T., Sorge R. P., Cocchiarale A., Piermarini V., Sabato A. F., Trabucchi M. and Romanini C. (2000) Plasma 5α-androstane-3α,17β-diol, an endogenous steroid that positively modulates GABAA receptor function, and anxiety: a study in menopausal women. Psychoneuroendocrinology 25, 659-675. ...
... Some of the colognes that have pheromones are Alpha Dreams L2K and Nexus Pheromones. Both of them contain a high concentration of androstenone. The Nexus Pheromones cologne goes a couple of steps further and comes with seven different pheromones designed to help you get noticed by women.
The earthy smell of a fresh beet may spark delicious thoughts for us, but for a fruit fly, that smell screams danger. Geosmin, a naturally occurring
The earthy smell of a fresh beet may spark delicious thoughts for us, but for a fruit fly, that smell screams danger. Geosmin, a naturally occurring
Learn more about Dehydroepiandrosterone (DHEA) at Aventura Hospital & Medical Center Supplement Forms/Alternate Names DHEA Sulfate Uses Principal Proposed...
E. coli Source ß-Glucuronidases
ß-Glucuronidase is a ~290 kDa tetrameric protein with an isoelectric point of 4.8.1 Unlike the enzyme preparations from mollusks that naturally contain ß-glucuronidase and sulfatase activities in almost equal amounts, the preparation of ß-glucuronidase from E. coli is essentially free of sulfatase activity. The enzyme from E. coli has a high rate of hydrolytic activity and it retains this activity during hydrolysis better than similar enzymes that are more sensitive to changes in the concentration of ß-glucuronide conjugates. The enzyme preparation from E. coli has been shown to be useful for determining the presence of androsterone, 17-hydroxycorticosteroids, and estriol in urine.2 The E. coli enzyme has also been shown to be more active against estrogen conjugates than other sources of the enzyme.3
Optimal pH: 6-7

References
1. Kim, D-H, et al., Biol. Pharm.
A method for the analysis of testosterone, androstenedione, 5β-dihydrotestosterone, 11-ketotestosterone, estrone, 17β-estradiol, 17α-hydroxyprogesterone, 17α,20β-dihydroxy-4-pregnen-3-one, 5β-pregnane-3α,17α,20α-triol, 5β-androstane-3α,17β-diol, 5β-androstane-3β,17β-diol, 5β-pregnane-3α,17α,20β-triol, 5β-androstane-3α,11β-diol-17-one, 5β-pregnane-3α,17α-diol-20-one, 17α,20β,21-trihydroxy-pregn-4-en-3-one and 11-deoxycortisol in water was developed using gas chromatography-mass spectrometry with selected ion monitoring.. Fish sex steroids were extracted from holding water using C18 SPE cartridges, and eluted using methanol. Free and glucuronide conjugate levels of steroids were determined, glucuronide conjugates by hydrolysis using β-glucuronidase prior to. derivatisation and free steroids by direct derivatisation. The method thus developed was applied to twelve goldfish holding water samples.. Androstenedione was found to be excreted in considerably higher quantities ...
by Matthew Cobb I suppose I have to explain why I stumbled across this video. I am giving a talk about the sense of smell tomorrow, and will be giving my (adult) audience some androstenone to smell. Some people have suggested this is a human pheromone - indeed it is marketed as a sex aid…
Credit: Dr Kai-hung Fung of Pamela Youde Nethersole Eastern Hospital in Hong Kong. Who would have imagined that the examination of a 33-year-old Chinese woman for thyroid disease would result in the picture shown above? Dr Kai-hung Fung was a co-winner in the photography category for the 2007 International Science and Engineering Visualization Challenge. The…
WASHINGTON Insect fragments and animal hairs taint 12 percent of imported spices, the Food and Drug Administration said Thursday.
In the final part of this series, we take a closer look at the evidence base supporting the use of immunological castration in the commercial setting. This article also considers the practical issues surrounding this new form of management, including operator safety and quality control.
In female zebrafish ovulation could be induced by male holding water, testis homogenates, and testis fractions containing steroid glucuronides. Deglucuronidation of these fractions led to a loss of ovulation-inducing potency, indicating steroid glucuronides as ovulation inducers. The chemical substances were perceived by the recipient females by means of olfaction. Incubation ... read more experiments showed the capacity of the testes to synthesize various C19 and C21 steroids and seven different steroid glucuronides, i.e., 17α,20β-dihydroxy-4-pregnen-3-one-, testosterone-, androsterone-, epiandrosterone-, 5α-androstane-3α,17β-diol-, and 5α-androstane-3β,17β-diol glucuronide. GC-MS analysis showed the presence of glucuronides of 5α-androstane-3α,17β-diol and cholesterol in male holding water, the latter probably originating from the liver. These compounds may be among the steroid glucuronides functioning as ovulation-inducing pheromones. show less ...
Weinstein, Y, "20alpha-hydroxysteroid Dehydrogenase. A t lymphocyte-associated enzyme." (1977). Subject Strain Bibliography 1977. 930 ...

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Epiandrosterone and Androsterone are very closely related. Androsterone is the 3-alpha isomer and epiandrosterone is the 3-beta ... 2. It is less active than androsterone and excreted in small amounts in normal human urine. 3. Epiandrosterone is a metabolite ... Most epiandrosterone supplements are actually a mix of the two isomers, meaning that they contain some androsterone as well as ... it is a less active 3β-isomer of the androgen Androsterone (A635535). Controlled Substance. Usage Anabolic steroid ...
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The biosynthesis of steroid glucuronides in the testis of the zebrafish, Brachydanio rerio, and their pheromonal function as...The biosynthesis of steroid glucuronides in the testis of the zebrafish, Brachydanio rerio, and their pheromonal function as...

... androsterone-, epiandrosterone-, 5α-androstane-3α,17β-diol-, and 5α-androstane-3β,17β-diol glucuronide. GC-MS analysis showed ...
more infohttps://dspace.library.uu.nl/handle/1874/16135

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Human Metabolome Database: Showing metabocard for Androsterone sulfate (HMDB0002759)Human Metabolome Database: Showing metabocard for Androsterone sulfate (HMDB0002759)

Androsterone sulfate. Description. Androsterone sulfate (Andros-S) is the most abundant 5-alpha-reduced androgen metabolite in ... Androsterone sulfate, sodium salt, (3alpha,5beta)-isomer. MeSH. Androsterone sulfate, sodium salt, (3beta,5alpha)-isomer. MeSH ... Showing metabocard for Androsterone sulfate (HMDB0002759). IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological ... Chang HJ, Shi R, Rehse P, Lin SX: Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone ...
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Androsterone is sulfated into androsterone sulfate and glucuronidated into androsterone glucuronide and these conjugates are ... Androsterone has been shown to naturally occur in pine pollen and is well known in many animal species. Androsterone was first ... Androsterone has been found to affect human behavior when smelled. Androsterone and its 5β-isomer, etiocholanolone, are ... Androsterone is found in the human axilla and skin as well as in the urine. It may also be secreted by human sebaceous glands. ...
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Androsterone glucuronide - WikipediaAndrosterone glucuronide - Wikipedia

Androsterone glucuronide (ADT-G) is a major circulating and urinary metabolite of testosterone and dihydrotestosterone (DHT). ... ADT-G is formed from androsterone by UDP-glucuronosyltransferases, with the major enzymes being UGT2B15 and UGT2B17. It is a ... 837-. ISBN 978-1-4557-2758-2. Metabocard for Androsterone Glucuronide (HMDB02829) - Human Metabolome Database. ... Androsterone sulfate Etiocholanolone glucuronide 3α-Androstanediol http://www.hmdb.ca/metabolites/HMDB02829 Jerome F. Strauss, ...
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Genetic deficiency of androsterone UDP-glucuronosyltransferase activity in Wistar rats is due to the loss of enzyme protein |...Genetic deficiency of androsterone UDP-glucuronosyltransferase activity in Wistar rats is due to the loss of enzyme protein |...

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Measuring faecal epi-androsterone as an indicator of gonadal activity in spotted hyenas (Crocuta crocuta)Measuring faecal epi-androsterone as an indicator of gonadal activity in spotted hyenas (Crocuta crocuta)

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Reference range data on androsterone glucuronide in healthy male and female volunteers and clinical uses of the assay |...Reference range data on androsterone glucuronide in healthy male and female volunteers and clinical uses of the assay |...

Androsterone glucuronide (ADG) is a major metabolite of the androgen dihydrotestosterone and has also been shown to arise from ... Reference range data on androsterone glucuronide in healthy male and female volunteers and clinical uses of the assay. Joanne ... Reference range data on androsterone glucuronide in healthy male and female volunteers and clinical uses of the assay (. ... the intracrine conversion of other adrenal androgens such as androstenedione and androsterone. ADG has been shown to be raised ...
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  • 1-Androsterone is currently available over the counter, and is contained in Iron Mag Labs 1-Andro-Rx, Advanced Muscle Science 1-Androsterone RD, and Primordial Performance 1-T. 1-Androsterone is a true prohormone, converting to 1-testosterone (dihydroboldenone). (passionchemical.com)
  • Orally, 1-Androsterone has about a 10% conversion rate to 1-testosterone. (passionchemical.com)
  • Androsterone is one of the androgens, which are steroid hormones that affect the masculinization of the fetus and child and that maintain or create masculine traits in adults. (chinacomputerparts.com)
  • Androsterone, or 5α-androstan-3α-ol-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. (wikipedia.org)
  • There is literally no other true product in the muscle building supplement category on the market that converts via the 2-step process to the powerful target hormone like 1-Androsterone RDe™ does. (vitanatural.net)
  • When 1-Androsterone is consumed (via our cyclodextrin based orally disintegrating tablets), it comes in contact with various tissues throughout the body (blood, fat, muscle, liver, etc) (1-3). (anabolicminds.com)
  • Androsterone (ADT) in serum and plasma is extracted with a mixture of hexane / ethyl acetate before drying under nitrogen. (panlaboratories.com)
  • The unnatural enantiomer of androsterone is more potent as a positive allosteric modulator of GABAA receptors and as an anticonvulsant than the natural form. (wikipedia.org)
  • Androsterone is a manly scent. (paxwa.com)
  • Numerous guys have reported utilizing the androsterone scent in sports or company environments to be seen and acquire respect. (paxwa.com)
  • It's use as a pheromone is born out of the fact that males with a higher ratio of Androsterone to Etiocholanone are more masculine. (chinacomputerparts.com)
  • Because 1-Androsterone is non-methylated, it can be stacked with methylated steroids or prohormones without putting additional stress on the liver. (passionchemical.com)
  • Elevated levels of Androsterone tend to have a cholesterol lowering effect and male sexual charecteristics , including male baldness. (panlaboratories.com)
  • ADT-G is formed from androsterone by UDP-glucuronosyltransferases, with the major enzymes being UGT2B15 and UGT2B17. (wikipedia.org)
  • When showed to women, it was discovered that men in the androsterone-sprayed pictures were rated as more attractive. (forumotion.com)
  • The two most common side effects seen with 1-Androsterone are lethargy (general sleepiness), and a loss of libido (the drive to have sex). (anabolicminds.com)
  • At that point you still only want to use the minimally effective dose of 4-AD that mitigates the 1-Androsterone side effects. (anabolicminds.com)
  • Androsterone has been found to affect human behavior when smelled. (wikipedia.org)
  • 1-androsterone review - If you are looking to learn more about 1 - Andro , you should definitely check out the reviews on our product page. (venez.fr)
  • Because of this you want to stagger your 4-AD dose as the typical 1-Androsterone sides to not prop their ugly heads up for a week or two into the cycle. (anabolicminds.com)
  • To understand how 1-Androsterone creates this powerful effect you must also understand the conversion pathway. (anabolicminds.com)