A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.
The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
Steroids that contain a ketone group at position 17.
A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.
Mutant strain of Rattus norvegicus which is used as a disease model of kernicterus.
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
A family of 3,3-bis(p-hydroxyphenyl)phthalides. They are used as CATHARTICS, indicators, and COLORING AGENTS.
The 17-alpha isomer of TESTOSTERONE, derived from PREGNENOLONE via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse.
The family of steroids from which the androgens are derived.
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
A species of gram-negative, aerobic rods formerly called Pseudomonas testosteroni. It is differentiated from other Comamonas species by its ability to assimilate testosterone and to utilize phenylacetate or maleate as carbon sources.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Derivatives of GLUCURONIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the 6-carboxy glucose structure.
The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.
An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. It plays an important role in the conversion of TESTOSTERONE into DIHYDROTESTOSTERONE and PROGESTERONE into DIHYDROPROGESTERONE.
Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
The flattened stroma cells forming a sheath or theca outside the basal lamina lining the mature OVARIAN FOLLICLE. Thecal interstitial or stromal cells are steroidogenic, and produce primarily ANDROGENS which serve as precusors of ESTROGENS in the GRANULOSA CELLS.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The surgical removal of one or both testicles.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
Mechanical food dispensing machines.
The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.
The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A synthetic pregnadiene derivative with anti-aldosterone activity.
The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.
A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
The use of fluorescence spectrometry to obtain quantitative results for the FLUORESCENT ANTIBODY TECHNIQUE. One advantage over the other methods (e.g., radioimmunoassay) is its extreme sensitivity, with a detection limit on the order of tenths of microgram/liter.
Chemical substances, excreted by an organism into the environment, that elicit behavioral or physiological responses from other organisms of the same species. Perception of these chemical signals may be olfactory or by contact.
Pheromones that elicit sexual attraction or mating behavior usually in members of the opposite sex in the same species.
Cell surface receptors that respond to PHEROMONES.
An accessory chemoreceptor organ that is separated from the main OLFACTORY MUCOSA. It is situated at the base of nasal septum close to the VOMER and NASAL BONES. It forwards chemical signals (such as PHEROMONES) to the CENTRAL NERVOUS SYSTEM, thus influencing reproductive and social behavior. In humans, most of its structures except the vomeronasal duct undergo regression after birth.
Sexual activities of animals.

Androgen secreting adrenocortical tumours. (1/160)

BACKGROUND: Androgen secreting adrenocortical tumours are rare in children and the determination of their malignant potential can be difficult. OBJECTIVES: To assess the presentation, histology, and clinical behaviour of these tumours. SETTING: Two tertiary referral centres. STUDY DESIGN: Retrospective analysis of children diagnosed with an androgen secreting adrenocortical tumour between 1976 and 1996. PATIENTS: Twenty three girls and seven boys aged 0-14 years. RESULTS: Pubic hair was observed in all children, clitoromegaly or growth of the phallus in 23 children, acceleration of linear growth in 22 children, and advanced bone age (> 1.5 years) in 18 children. Hypersecretion of androgens was detected by assessment of serum androgen concentrations alone in four patients and by 24 hour urine steroid excretion profiles in 22 patients. All 16 tumours measuring < 5 cm in diameter were benign. Of the tumours measuring 5-9 cm, three were malignant and seven were benign, whereas all four tumours > 10 cm were malignant. Histological slides were available for reassessment in 25 children. Although mitoses and necrosis were more characteristic of tumours with malignant behaviour, no exclusive histological features of malignancy were seen. CONCLUSION: Histological criteria for malignancy are not reliable, whereas tumour size is important in assessing malignant potential.  (+info)

Identification by chimera formation and site-selected mutagenesis of a key amino acid residue involved in determining stereospecificity of guinea pig 3-hydroxysteroid sulfotransferase isoforms. (2/160)

The 3-hydroxysteroid sulfotransferases that have been isolated and cloned from humans and rodents appear to have broad substrate specificities. In the guinea pig, however, two 3-hydroxysteroid sulfotransferases have been isolated that function according to an innate stereospecificity: the alpha-isoform acts on steroids with a 3-hydroxyl group oriented in the alpha position, whereas the beta-isoform acts on steroids where the 3-hydroxyl group is in a beta orientation. To examine the structural basis for this remarkable stereoselectivity, chimeras of the two enzymes, which are 87% identical, were constructed. A chimera consisting of the NH(2)-terminal 91 amino acids of the alpha-isoform and the COOH-terminal 196 amino acids of the beta-isoform displayed activity similar to that of the alpha-isoform. Site-selected mutagenesis of this 3alpha/beta-hydroxysteroid sulfotransferase chimera involving the 12 amino acid differences that exist between the two isoforms within the 91 amino acid NH(2)-terminal region revealed that the amino acid residue at position 51 plays a fundamental role in determining the stereospecificity exhibited by the alpha- and beta-isoforms, i.e. if residue 51 is an asparagine, alpha activity predominates, whereas if an isoleucine is in that position, beta activity prevails.  (+info)

Dexamethasone-induced apoptosis of mouse thymocytes: prevention by native 7alpha-hydroxysteroids. (3/160)

Dehydroepiandrosterone (DHEA) has been shown to decrease the dexamethasone (DEX)-induced apoptosis of thymocytes and to be one of the native 3beta-hydroxysteroids extensively 7alpha-hydroxylated in thymus. This led us to question whether DHEA or 7alpha-hydroxy-DHEA is responsible for the decrease in DEX-induced apoptosis of thymocytes and whether this property is shared with other native 3beta-hydroxysteroids and their 7alpha-hydroxylated metabolites. Treatment of mice with DHEA or 7alpha-hydroxy-DHEA prior to DEX led to a smaller decrease in thymus weight than with DEX alone and to a disappearance of the DEX-induced changes in thymocyte phenotypes. Thymocyte apoptosis induced by DEX treatment was significantly lowered in DHEA- and 7alpha-hydroxy-DHEA-treated thymi, even after 18 h culture with additional 10-6 mol/L DEX. Extensive apoptosis of thymocytes cultured with 10-7 mol/L DEX was brought back to control levels when 10-5 mol/L 7alpha-hydroxy-DHEA or 10-5 mol/L 7alpha-hydroxy-epiandrosterone was added. After use of DHEA and epiandrosterone or pregnenolone, less significant and no significant changes were obtained, respectively. These findings imply that the 7alpha-hydroxylation of 3beta-hydroxysteroids may be a prerequisite for an exquisite regulation of the thymocyte-positive selection driven by the glucocorticoids produced in thymic epithelial cells.  (+info)

Hormone profiles in hormone-dependent cancers. (4/160)

Studies on the relationship of urinary excretion of androgen metabolites and estrogens to the natural history of breast cancer are reviewed. The importance of distinguishing between "within-population" studies (i.e., cancer patients versus normal controls) and "between populations" studies (i.e., low-risk versus high-risk populations) is emphasized, and it is pointed out that "qualitative" agreement (i.e. the same direction of differences) between the two types of studies must be present in order to implicate a hormonal parameter as a determinant of the natural history of breast cancer. For reasons detailed in this paper, it is concluded that the reported relationship of low urinary androgen metabolite excretion to increased risk of developing breast cancer and poor response to adrenalectomy or hypophysectomy and the validity of the "estriol hypothesis," namely, that a high urinary ratio of estriol to estrone-plus-estradiol in early life is protective against subsequent development of breast cancer, are both dubious. A new hypothesis concerning the relationship of estrogens to breast cancer risk is presented: "A period of of time, prior to age 30, during which the amount of biological availability of active estrogens' (i.e., estrone and estradiol) is diminished, protects against subsequent development of cancer." This hypothesis is shown to be compatible with the epidemiological and biochemical data. Reports concerning the influence of nutrition on endocrine parameters are reviewed. Inanition and obesity have been shown to alter steroid metabolism but it is not known whether nutritional "microdifferences" (i.e., differences between populations or individuals that are due to cultural, geographic, or socioeconomic factors, but that fall within the range of "normal" or adequate nutrition) can also alter steroid metabolism.  (+info)

Strain differences in rat liver (UDP-glucuronyltransferase activity towards androsterone. (5/160)

Male Donryu, Wistar King rats showed discontinuous variations in hepatic microsomal UDP-glucuronyltransferase activities towards androsterone, but not towards testosterone, bilirubin, phenolphthalein and 4-nitrophenol. Fresh microsomal fraction with a low transferase activity towards androsterone formed 0.049--0.080 nmole of glucuronide/min per mg of protein, whereas fresh microsomal fraction with a high transferase activity towards androsterone formed 0.335--0.557 nmol of glucuronide/min per mg of protein. The microsomal fraction with low enzyme activity towards androsterone was not stimulated by treatment with Triton X-100 or freezing and thawing. In contrast, male Long Evans and Sprague-Dawley rats did not exhibit such diversity.  (+info)

Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men. (6/160)

Men with higher endogenous 5alpha-reductase activity may have higher prostate cancer risk. This hypothesis raises two questions: (a) Could racial differences in 5alpha-reductase activity explain the observed racial differences in prostate cancer risk? and (b) Could a man reduce his activity level by modifying his lifestyle? To address these questions, we measured two hormonal indices of 5alpha-reductase activity [serum levels of androstane-3alpha-17beta-diol glucuronide (3alpha-diol G) and androsterone glucuronide (AG)] in healthy, older African-American, white, and Asian-American men, who are at high, intermediate, and low prostate cancer risk, respectively. We also examined associations between these metabolite levels and such lifestyle characteristics as body size and physical activity as well as select aspects of medical history and family history of prostate cancer. Men included in this cross-sectional analysis (n = 1054) had served as control subjects in a population-based case-control study of prostate cancer we conducted in California, Hawaii, and Vancouver, Canada and provided information on certain personal attributes and donated blood between March 1990 and March 1992. In this study, concentrations of 3alpha-diol G declined significantly with age and increased significantly with body mass index. Mean levels of 3alpha-diol G, adjusted for age and body mass index, were 6.1 ng/ml in African-Americans, 6.9 ng/ml in whites and 4.8 ng/ml in Asian-Americans. These differences were statistically significant (African-Americans versus whites: P < 0.01; whites versus Asian-Americans: P < 0.001). Concentrations of AG decreased significantly with age, but only in whites, and were unrelated to any of the reported personal attributes. Mean levels of AG, adjusted for age, were 44.1 ng/ml in African-Americans, 44.9 ng/ml in whites, and 37.5 ng/ml in Asian-Americans (Asian-Americans versus whites, P < 0.001). In conclusion, older African-American and white men have similar levels of these two indices of 5alpha-reductase activity, and these levels are higher than those of older Asian-American men. This difference may be related to the lower prostate cancer risk in Asian-Americans.  (+info)

16alpha-bromoepiandrosterone, a dehydroepiandrosterone (DHEA) analogue, inhibits Plasmodium falciparum and Plasmodium berghei growth. (7/160)

Dehydroepiandrosterone (DHEA) and its analogue, 16alpha-bromoepiandrosterone (alpha-epi-Br), may have activity against viral and parasitic infections, including human immunodeficiency virus (HIV) and Cryptosporidium parvum. Therefore, we evaluated its antimalarial effects on Plasmodium falciparum and Plasmodium berghei. In vitro, chloroquine (CQ)-sensitive and resistant strains of P. falciparum parasitized red blood cells were incubated with escalating doses of alpha-epi-Br or CQ. In vivo, 62 rats were infected with P. berghei and treated with CQ or alpha-epi-Br. At the highest doses tested against a CQ-sensitive strain, parasitemias decreased from 25.4% in the saline control group to 4.3% and 4.8% in the alpha-epi-Br and CQ groups, respectively (P < 0.05). Against two CQ-resistant strains, parasitemias decreased from 22.3-28.8% and 24.8-30% in the CQ and saline groups, respectively, to 2.5-2.7% in the alpha-epi-Br groups (P = 0.003). In vivo, on Day 4, parasitemias decreased from 23% in the saline group to 9-12% and 12% in the in alpha-epi-Br and CQ groups, respectively (P < 0.05). These data demonstrate that alpha-epi-Br shows activity against CQ-sensitive and resistant strains of P. falciparum in vitro. At the doses tested against P. berghei in vivo in rats, alpha-epi-Br is comparable to CQ.  (+info)

Familial resemblance for free androgens and androgen glucuronides in sedentary black and white individuals: the HERITAGE Family Study. Health, Risk Factors, Exercise Training and Genetics. (8/160)

Familial correlation analyses were used to evaluate the familial aggregation of plasma androgens and androgen glucuronides (testosterone (TESTO), dihydrotestosterone (DHT), androstane-3 alpha,17 beta-diol glucuronide (3 alpha-DIOL-G), and androsterone glucuronide (ADT-G)) in 505 members of 99 white families and 296 members of 111 black families participating in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study. Each of these four measures was determined by RIA after separation of conjugated and unconjugated steroid using C18 column chromatography. All participants were sedentary prior to being including in this study. Significant spouse correlations, as well as parent-offspring and sibling correlations, were found for TESTO, DHT, 3 alpha-DIOL-G, and ADT-G in the white sample, suggesting that common familial environments and genes contribute to the familial resemblance. In the black sample, significant sibling and parent-offspring correlations were found for all four phenotypes, while the spouse correlation was marginally significant for 3 alpha-DIOL-G and not significant for TESTO, DHT, and ADT-G. The non-significance of spouse correlations in the black individuals may be due to the small number of spouse pairs. The maximal heritability estimates of TESTO, DHT, 3 alpha-DIOL-G, and ADT-G were 69%, 87%, 74%, and 56% for white individuals and 70%, 73%, 62%, and 48% for black individuals respectively. Sex differences in heritability estimates were found in the white individuals, but they were less dramatic in the black individuals. In conclusion, plasma levels of androgens and androgen glucuronides are highly heritable in both white individuals and black individuals. There are notable sex differences in the white individuals.  (+info)

Product Description Product Description Factory Supply Prohormone Steroid Powder Epiandrosterone CAS 481-29-8 Epiandrosterone CAS: 481-29-8 Epiandrosterone MF: C19H30O2 Epiandrosterone MW: 290.44 Epiandrosterone EINECS: 207-563-3 Epiandrosterone Purity: 99%min Epiandrosterone Appearance: White crystalline powder Epiandrosterone Standard: USP/BP/EP/Enterprise Standard Epiandrosterone Usage: Anabolic steroid; A steroid hormone that is present in normal human urine as a minor constituent , it is a less…
Epiandrosterone is a prohormone that is completely legal and available over the counter. It may also appear under the name 3b-hydroxy-etioallocholan-17-one. Epiandrosterone is a precursor to Stanolone, a powerful steroid hormone. Epiandrosterone can be found naturally occuring in most mammals and is excreted in urine as a normal part of human metabolism. One of the reasons that this prohormone is legal because it has been found to be naturally occurring in pine pollen. Epiandrosterone and Androsterone are very closely related. Androsterone is the 3-alpha isomer and epiandrosterone is the 3-beta isomer of this compound. The actions of the two isomers in the body are different, but still very similar. Most epiandrosterone supplements are actually a mix of the two isomers, meaning that they contain some androsterone as well as the main ingredient epiandrosterone ...
Epiandrosterone is a naturally occurring steroid synthesized in the adrenal cortex, gonads, brain, and gastrointestinal tract. It is less active than androsterone and excreted in small amounts in normal human urine. Epiandrosterone is a metabolite of the most abundant adrenal androgenic steroid dehydroepiandrosterone (DHEA) in young adult humans, but is not completely inactive and is considered an effector as well. Epiandrosterone is a precursor or substrate for cytochrome P450 species and enzymes (EC 1.14.13.100, 25-hydroxycholesterol 7alpha-hydroxylase) that produce 7alpha- and 7beta-hydroxylated metabolites in the human brain and other organs. These 7-hydroxylated derivatives exert anti-glucocorticoid and neuroprotective effects (PMID: 17017935 , 12475725 , 15650074 , 15784286 ...
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5α-androstenone is a very lipophilic molecule. The water solubility of 5α-androstenone is only 230 μg/l at 25°C [18]. The steroid appears to be easily transferred from plasma to adipose tissue. It has been found that if the level of 5α-androstenone in peripheral plasma exceeds about 15 ng/ml, a heavy accumulation of androstenone in fat usually follows [19]. Sinclair et al [20] reported that peripheral plasma levels of androstenone below 15 ng/ml were associated with low androstenone concentrations in fat, while a wide range of androstenone concentrations can be found in fat in animals with plasma levels above this value.. The levels of androstenone in adipose tissue can be doubled within a day following stimulation of androstenone production by the testes by hCG injection [21]. However, when the concentration of androstenone in peripheral plasma decreases from high levels, the concentration in adipose tissue do also gradually decrease. Thus there appear to be a dynamic relationship between ...
1-Androsterone prohormone 1-DHEA Pharmade USP Raw Prohormone Powders1-Androsterone, prohormone, 1-DHEA1-androsterone (aka 1-DHEA) is a prohormone that undergoes a two step conversion through the enzy
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Product Description Product Description Sex Hormone Powder Androgen 1- DHEA /1-Androsterone Safe Shipping Quick details 1-DHEA / 1-Androsterone Alias:Androsta-1-ene-3b-ol,17-one;Androstene-3b-ol,17-one;1-Dehydropiandrosterone CAS register number:76822-24-7 Assay:99% EINECS No.:76822-24-7 Appearance: white or off white crystalline powder Related Substances: Pharmaceutical Grade Storage: Shading, confined preservation Description: Items Tested Specification Result Characters White or almost white crystalline powder Confirms Assay (HPLC) 99.0--101.0%…
Dehydroepiandrostenedione (more correctly didehydroepiandrosterone), also known as androstenolone or prasterone, as well as 3β-hydroxyandrost-5-en-17-one or 5-androsten-3β-ol-17-one, is an important endogenous steroid hormone. It is the most abundant circulating steroid hormone in humans, in whom it is produced in the adrenal glands, the gonads, and the brain, [4] where it functions predominantly as a metabolic intermediate in the biosynthesis of the androgen and estrogen *** steroids. However, Dehydroisoandrosterone also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a neurosteroid. Dehydroisoandrosterone Usage ...
Alternative (backdoor) androgen production and masculinization in the human fetus{{#pmid:30763313,PMID30763313}} Masculinization of the external genitalia in humans is dependent on formation of 5α-dihydrotestosterone (DHT) through both the canonical androgenic pathway and an alternative (backdoor) pathway. The fetal testes are essential for canonical androgen production, but little is known about the synthesis of backdoor androgens, despite their known critical role in masculinization. ...Results show that androsterone is the principal backdoor androgen in the male fetal circulation and that DHT is undetectable (,1 ng/mL), while in female fetuses, there are significantly lower levels of androsterone and testosterone. In the male, intermediates in the backdoor pathway are found primarily in the placenta and fetal liver, with significant androsterone levels also in the fetal adrenal. Backdoor intermediates, including androsterone, are only present at very low levels in the fetal testes. This ...
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pheromonesLove Scent Pheromone - What are Androsterone Pheromones?Once the only form of communication between animals, pheromones are chemical messengers from one being to another that affect the behavior of the receiver. From ...
1903-1995) German organic chemist and biochemist. Butenandt, who was born at Bremerhaven-Lehe (now Wesermünde) in Germany, took his first degree in chemistry at the University of Marburg and gained his doctorate in 1927 under Adolf Windaus at Göttingen. He remained at Göttingen as Privatdozent until 1933. Following the work of Windaus on cholesterol, Butenandt investigated the sex hormones and in 1929 he isolated the first pure sex hormone, estrone, from the urine of pregnant women (the compound was also discovered independently by Edward Doisy). A search for the male sex hormone resulted in the isolation in 1931 of 15 milligrams of androsterone from 3960 gallons of urine.. In 1933 he became professor of organic chemistry at the Danzig Institute of Technology and here he demonstrated the similarities between the molecular structures of androsterone and cholesterol. His proposed structure for androsterone was confirmed by Leopold Ružičkas synthesis in 1934. The male hormone testosterone was ...
Androsterone then again is a masculine pheromone that lacks the aggressive vibe produced by androstenone. From here signals are despatched by neurons (nerves) to the accent olfactory bulbs, which is the part of the brain liable for processing the data relayed by the pheromones and mediating a response. Curiously, essentially the most considerable pheromone on the market is androstenone , but this pheromone has been shown to don`t have any motion within the VNO. It picks up scents that aren`t normally detected, ones that carry an excessive amount of details about an individual. It might therefore be doable to tailor a pheromone combine specifically for an individual, in essence creating the impression of a great companion, but in the meanwhile that is beyond current know-how. You`ll find a lot of web sites which have information about the science of scent attraction ...
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1) ,endocrinology, A male sex hormone, derived from progesterone, which is seven times weaker than testosterone. It is found in the plasma and urine of both men and women. Formula: C19H30O2. (2) A steroid hormone excreted in urine that reinforces masculine characteristics ...
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Matrix metalloproteinases (MMPs) are a family of Zinc- dependent endopeptidases that degrade extracellular matrix proteins. MMP-9 serum is quantitated using an ELISA (Enzyme Linked Immunosorbent Assay) procedure. It is a two-step sandwich-type immunoassay using two antibodies to MMP-9 Learn more.
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Phero-Max mengandungi bahan pheromone sintetik bernama Androstenone, 5-alpha-an-drost-16-ene-one, androstenol, androsterone, estratetraenol dan androstadienone
Phero-Max mengandungi bahan pheromone sintetik bernama Androstenone, 5-alpha-an-drost-16-ene-one, androstenol, androsterone, estratetraenol dan androstadienone
Kit Contents: Adrenaline Epinephrine, Aldosterone, Androsterone, Calcitonin, Corticosterone, Cortisol, DHEA Dehydroepiandrosterone, Estradiol, Estriol, Estrogen, Estrone, FSH Follicle-stimulating Hormone, Gastrin, Glucagon, HGH Human Growth Hormone, Insulin, LH Luteinizing Hormone, Melatonin, Noradrenaline Norepinephri
Although testosterone was not isolated until 1935, four years after its metabolite androsterone, the basic origins and effects of the substance have been known for a much longer period of time.
Although androsterone and dehydroandrosterone, two substances of androgenic character, have been separated from human urine, very little is known as to the significance of their occurrence and still less as to the fluctuations in the rate of excretion in health and disease. It is generally assumed that these substances are waste products formed from testosterone secreted into the blood stream by the gonads, but it is just as reasonable to expect that one or both of these urinary products may be precursors of testosterone or that they, or still other androgenic substances, may originate in part in other tissues or ...
Androgens are the male sex hormones and include testosterone, androsterone and androstenedione. The main function of these hormones is to promote the
4 Glory by Sparta Nutrition with GenXLabs Testabol with 4-Androsterone: A compound that is also known as 4-DHEA and is a DHEA derivative, this compound converts into the master hormone, testosterone. Testosterone is both anabolic and androgenic, meaning
Androsterone Pheromone Concentrate, What are the MostPheromones have left the arena of little-known biological chemicals and entered the realm of topics that ca
Androsterone Reviews - Is He Straight Into You?Probably the most is it the real thing or is it a scam? are they the same? could start with extremely little chemistry at all. ...
Etiocholanolone, also known as 5β-androsterone, as well as 3α-hydroxy-5β-androstan-17-one or etiocholan-3α-ol-17-one, is an etiocholane (5β-androstane) steroid as well as an endogenous 17-ketosteroid that is produced from the metabolism of testosterone. It causes fever, immunostimulation, and leukocytosis, and is used to evaluate adrenal cortex function, bone marrow performance, and in neoplastic disease to stimulate the immune system. Etiocholanolone is also known to be an inhibitory androstane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor, and possesses anticonvulsant effects. The unnatural enantiomer of etiocholanolone is more potent as a positive allosteric modulator of GABAA receptors and as an anticonvulsant than the natural form. Etiocholanolone is produced from 5β-dihydrotestosterone, with 3α,5β-androstanediol as an intermediate. Etiocholanolone glucuronide Epietiocholanolone Androsterone Epiandrosterone Reddy DS (2010). Neurosteroids: endogenous ...
To the Editor: In the December 1967 issue of the ANNALS, statement on p. 1291 (1) that the syndrome of etiocholanolone fever has been widely accepted was supported by reference to one textbook of medicine (2) but not to another (3). In both books, the subject is discussed and related to periodic fever and to periodic peritonitis. Etiocholanolone fever as such may exist, but its connection with febrile periodic disorders is unproved, to say the least. Bondy, who first proposed a relation, later questioned whether increase in the amount of etiocholanolone causes the fever in periodic disorders, is an incidental ...
Materials. 4MU, 4-methylumbelliferone-β-d-glucuronide, β-glucuronidase (from Escherichia coli), alamethicin (from Trichoderma viride), amitriptyline (hydrochloride salt), androsterone, AZT, canrenoic acid (potassium salt), GAZT (3′-azido-3′-deoxythymidine 5′-β-d-glucuronide), hecogenin, phenylbutazone, TFP (dihydrochloride salt), trifluoroacetic acid, quinidine (hydrochloride monohydrate salt), quinine (hemisulfate salt hydrate), sulfinpyrazone, UDPGA (trisodium salt), and dialysis cellulose membrane (molecular mass cutoff 12,000 Da) were purchased from Sigma-Aldrich (St. Louis, MO). Solvents and other reagents were of analytical reagent grade.. Human Liver Microsomes. Microsomes were prepared from four human livers (HL10, 12, 29, and 40; obtained from the Department of Clinical Pharmacology human liver bank) according to the method of Bowalgaha et al. (2005). Microsomes were activated by preincubation with alamethicin (50 μg/mg protein) on ice for 30 min before their use in ...
Human pheromones are said to increase sex drive and many products claim to have an aphrodisiac property that will help to promote a higher libido and attract members of the opposite sex. There are four main molecules that make up most pheromone colognes and over the counter products. These include androstenone, androsterone, androstadienone and androstenol. The different molecules work in different ways to achieve their desired effects. Sexual products for instance that contain higher levels of androstenone tend to work better as attractants for the opposite sex.. Androstenone - Of the four basic molecules, androstenone contains the most potent molecules regarding sexual attraction. This particular pheromone can increase sexual desire in women and can help men to be more attractive to women looking for a potential mate or sexual partner.. Androsterone - Those products that contain androsterone help to make wearers seem more trustworthy and appear more masculine.. Androstadienone - Products that ...
Boar taint is an offensive odour, which affects the smell and taste of cooked pork, resulting mainly from the accumulation of skatole and androstenone in the back fat of intact males, explain A.B. Strathe of the University of Copenhagen and colleagues there and at the Danish Agriculture & Food Councils Pig Research Centre.. The aim of their study published in Journal of Animal Science was to estimate genetic parameters for skatole and androstenone and their genetic relationship to production and litter size traits. Concentrations of skatole and androstenone in the back fat were available for approximately 6,000 and 1,000 Landrace boars, respectively. The concentrations were log-transformed to align phenotypic measures to a normal distribution. Heritability estimates for Log(skatole) and Log(androstenone) were 0.33 and 0.59, respectively. The genetic correlation between the two measures of boar taint was 0.37, suggesting that genetic selection against boar taint based on only one of the chemical ...
Androsterone can be worn by women, though the effects of the pheromone are not as strong when women wear it. Men will usually experience an elevated mood when detecting this pheromone on a woman. Androsterone is usually mixed with other pheromones in order to enhance the effectiveness of the other chemicals, as it acts as a subtle boost to the other pheromones that will make them and it more effective. There are no effects resulting from too much androsterone, making it one of the best and strongest pheromones. ...
Alpha-Androstenol, BETA-Androstenol, Androsterone, Androstenone, Androstadienone, Androstanone, Copulinen, Pregnenolone, Epiandrosterone und Estratetraenol ...
According to some surveys, about 50% of adult humans cant detect androstenone, unless the concentration is extremely high. Those who can detect androstenone say that its smell is not very pleasant. Androstenone is the main pheromone that men unknowingly secrete that attract women. Both men and women secrete pheromones when they sweat. However, since our body naturally only secretes small amounts of pheromones, they are effective for only a brief amount of time. The good news is that scientists have succeeded in identifying and synthesizing both androstenone and androstenol in the laboratory ...
Pheromone information are usually detected with an wood a few inches within the nasal area referred to as the actual Vomeronasal Wood ( VNO ). Once the VNO registers the actual pheromone, this sends an answer indication for the mind. So, while the sense of smell is mainly discussed in research associated with pheromone fascination, it is really the substance reaction that develops, instead of a particular identifiable odor. To go into detail, she responds for a chemistry over a subconscious level, along with feelings associated with attraction, arousal, interest and also exhilaration. Accept the way things are in life. Only then will you be able to accept these points on Pheromone. Pheromone can be considered to be part and parcel of life ...
Originally named Chikara 7, after the number of pheromone compounds, this product contains the three pheromones found in most pheromone products: androstenol, androstenone and androsterone, as well as four new ingredients never before used in perfumery. The total guaranteed pheromone content per bottle is 10 mg. Chikara is great on its own, but it can also be combined with other products, especially those with more androstenone. This product is also available in gel packs ...
We synthesized two series of androstane derivatives as inhibitors of type 3 and type 5 17β-hydroxysteroid dehydrogenases (17β-HSDs). In the first series, four monospiro derivatives at position C17 were prepared from androsterone (ADT) or epi-ADT. After the protection of the alcohol at C3, the C17-ketone was alkylated with the lithium acetylide of tetrahydro-2-(but-3-ynyl)-2-H-pyran, the triple bond was hydrogenated, the protecting groups hydrolysed and the alcohols oxidized to give the corresponding 3-keto-17-spiro-lactone derivative. The other three compounds were generated from this keto-lactone by reducing the ketone at C3, or by introducing one or two methyl groups. In the second series, two dispiro derivatives at C3 and C17 were prepared from epi-ADT. After introducing a spiro-δ-lactone at C17 and an oxirane at C3, an aminolysis of the oxirane with L-isoleucine methyl ester provided an amino alcohol, which was treated with triphosgene or sodium methylate to afford a carbamate- or a morpholinone
Nexus Pheromones Attract Women Instantly 8. amzn_assoc_default_search_phrase = Pheromone Colognes for Men; Take your time and get one that suits you best, and you who knows? 2020 Buyers Guide for Best Rated Pheromones Pheromones-Experts.com was established to Rate Review and Compare different Pheromone products on the market. The best thing about it is that it lasts long letting you enjoy its miraculous effect longer unlike other colognes for men. Unlike other similar products, this one does not have an overwhelming smell and you can effortlessly pair it with another cologne. Have a look at our list and choose the ones you like the most. We Do The Research So You Get the Results! 6 Best Polo Colognes For Men in 2021 - Reviews & Top Picks . The reaction you get when you wear it … To put this in another way, this pheromone cologne for men contains more than 18g of Androstenol, Androsterone Pheromone, Androstenone and Androstadienone blend. This is among the few effective pheromones colognes ...
Ive never had success with women and Ive struck out more times than I can count. Its not that Im nervous to approach them, its just that I have a hard time closing the deal, if you know what I mean. I heard from a buddy of mine about a pheromone called Alpha 7 Unscented. Ive seen pheromones advertised before but I never knew if they actually worked or not. But since my buddy recommended it, I decided to give Alpha 7 a try. I decided to try it out at the new club that just opened up downtown.. What Is It?. The Alpha 7 Unscented arrived in a small vial in a plain box. I still had time before I was going to head to the club, so I decided to get on Google to research it. I found out that Alpha 7 unscented is an andro heavy pheromone that contains 40% more pheromone than competing pheromone products except top brands like Pherazone. The mixture is comprised of 6mg of Androstenone and 1mg of Androsterone.. How Does It Work?. But what does all of that mean? Well, apparently, Alpha 7 is pretty ...
According to some Chikara review, the cologne is actually a mixture of three essential pheromones, particularly androsterone, androstenone, and androstenol in addition to other ingredients. This is the reason behind its success since the vomeronasal organ can detect them, making the wearer appear sexually attractive to the opposite sex. This organ picks up the pheromone and carries it to the hypothalamus that in flip, sends signals to the brain. An individual carrying Chikara is made extra attractive the opposite sex so his chances of getting a good associate enhance - that is principally how Chikara works. The pheromone that is being released is actually way superior than those that are being produced from the body so an individual can get to become more appealing to different people particularly to the opposite sex ...
Pherazone For Women - 15X Strength Buy Today and SAVE $50.00 Reported to be the Most Powerful Concentration of Pheromones on Marketplace Today with a Staggering 108 mg of pheromones per ounce Contains 7 powerful pheromones (5-alpha-Androstenone, 5-alpha-Androstenol, Androsterone, Androstadienone, Androstadienol, beta-a
Hormone Regulation Kit 1-Andro + 4-AD + Arom-X + 1-Androsterone Remember when Prohormones worked as advertised without harsh side effects or dangers?
Make unshaken she cognize how and though so that wonting this physical medicine. They beggary over against acquaintance but herself are ovulating and yet in order to nurture sensual pairing. This preference accretion the look-in in point of a pregnancy.. Visit your assist pale normalcy meticulousness accomplished as ethyl gas checks vis-a-vis your enrichment. Yours truly may homelessness tests into retardment the androsterone levels opening your group cross themselves may own on route to ceremony home-urine tests so lacuna parce que ovulation. Essentialize toward control a certain appointments.. Compared in passage to unessential affluence treatments, this embryology does not pretty much offshoot your chances re having multiform babies. An exasperated arise with regard to having twins may indwell near capriciously 5 disengaged every 100 women who blaze this medication.. Stop siren this snake medicine decisively and correspond with your starets erminites normalcy sadness diplomatist if I ...
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.‎Melatonin and Xanax Drug · ‎Aspirin Low Strength and · ‎Benadryl · ‎Tylenol. Learn about drug interactions between loratadine-pseudoephedrine oral and melatonin sl and use the RxList drug interaction checker to check drug combinations. Allergy-Congestion Relief-D Oral, Claritin-D 12 Hour Oral, Claritin-D 24 Hour Oral, Clear-Atadine-D Oral, Lorata-D Oral, lorata-dine D Oral, Loratadine-D Oral. My androsterone told me to take a Claritin befor bed. Epoxy 4, , cuztomize.info My escort told me to take a Claritin befor can you take claritin and melatonin together.. ...
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Androsterone is a chemical byproduct created during the breakdown of androgens, or derived from progesterone, that also exerts ... Androsterone. 10. 5α-Dihydrotestosterone (DHT) was 2.4 times more potent than testosterone at maintaining normal prostate ...
Adolf Butenandt discovers androsterone. The first electroencephalography is performed by Hans Berger. Ernst Ruska and Max Knoll ...
Adolf Butenandt discovers androsterone. John Haven Emerson and August Krogh introduce new forms of negative pressure ventilator ...
androsterone acetate. 1482-78-6 C21H32O3. oxymetholone. 434-07-1 ...
Androsterone Epiandrosterone Etiocholanolone Arun Nagrath; Narendra Malhotra; Seth Shikha (31 July 2012). Progress in ...
1931 - Adolf Butenandt discovered androsterone. 1932 - Hans Adolf Krebs discovered the urea cycle. 1933 - Tadeus Reichstein ...
... , also known as 5β-androsterone, as well as 3α-hydroxy-5β-androstan-17-one or etiocholan-3α-ol-17-one, is an ... Androsterone Epiandrosterone Epietiocholanolone Etiocholanolone glucuronide Reddy DS (2010). Neurosteroids: endogenous role in ... Kaminski RM, Marini H, Kim WJ, Rogawski MA (June 2005). "Anticonvulsant activity of androsterone and etiocholanolone". ... "Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural ...
Androstane Androsterone Estratetraenol Gower, D. B.; Ruparelia, B. A. (1993). "Olfaction in humans with special reference to ...
Kaminski RM, Marini H, Kim WJ, Rogawski MA (June 2005). "Anticonvulsant activity of androsterone and etiocholanolone". ... 3α-Androstanediol 3β-Androstanediol Androsterone Epiandrosterone Hormones, Brain and Behavior Online. Academic Press. 18 June ...
Kaminski RM, Marini H, Kim WJ, Rogawski MA (2005). "Anticonvulsant activity of androsterone and etiocholanolone". Epilepsia. 46 ... 5α-androst-16-en-3-one Androsterone: 5α-androstan-3α-ol-17-one Estratetraenol: estra-1,3,5(10),16-tetraen-3-ol 4-Androstadienol ... GABAA receptor positive allosteric modulator Androsterone: 5α-androstan-3α-ol-17-one - GABAA receptor positive allosteric ...
Androgen backdoor pathway Androsterone van Rooyen D, Gent R, Barnard L, Swart AC (April 2018). "The in vitro metabolism of 11β- ... 11-Ketoandrosterone is a 11-keto form of androsterone. 11-Ketoandrosterone belongs to a group of 11-oxyandrogens, i.e. 11- ...
E.h.) Androsterone Conjugated estriol Epiandrosterone Pregnenolone Szöllösi-Janze, Margit (2001). Science in the Third Reich ( ... progesterone and androsterone 1942: War Merit Cross, Second Class (Germany) 1943: War Merit Cross, First Class (Germany) 1953: ...
It is excreted mainly as androsterone glucuronide and etiocholanolone glucuronide. It is also excreted to a small extent as ... The major urinary metabolites of testosterone are androsterone glucuronide and etiocholanolone glucuronide. The elimination ...
Androstanediol glucuronide Androsterone glucuronide Etiocholanolone glucuronide Testosterone glucuronide Wishart, David S.; ...
Silva's team was unable to explain the presence of androsterone in the Jan. 9 test. The commission rejected the defense and ... Silva also had traces of androsterone, a form of endogenous testosterone and also another banned substance. Silva was also ... overturned after he failed a drug test for drostanolone and androsterone. Diaz also failed a drug test for marijuana. The ...
In 2013 Calja was suspended for two years for using androsterone. He competed at the 2016 Summer Olympics in 69kg division ...
Androsterone. 1.1. 14. 2.0. 4.22. 0.73. 0.52. 94.5. 1.5. 4.18. 1.77. 0.54. 93.5 ...
The result did not stand, however, as Sun failed a drugs test for androsterone. Her test at the Beijing Marathon the previous ...
3β-Androstanediol Androsterone glucuronide Etiocholanolone glucuronide Moghissi E, Ablan F, Horton R (September 1984). "Origin ...
Silva's team was unable to explain the presence of androsterone in the Jan 9 test. The commission rejected the defense and ...
Androsterone and etiocholanolone are then glucuronidated and to a lesser extent sulfated similarly to testosterone. The ... Subsequently, 3α-androstanediol and 3α-etiocholanediol are converted by 17β-HSD into androsterone and etiocholanolone, which is ... An additional 40% of testosterone is metabolized in equal proportions into the 17-ketosteroids androsterone and etiocholanolone ...
Iraqi weightlifter Mohammed al Aifuri tested for positive for etiocholanolone and androsterone. It was his second failed drug ...
OH-androsterone) on 7 May 2006, at the International 42nd Presidential Cycling Tour of Turkey. He received a 2-year suspension ...
Silva's team was unable to explain the presence of androsterone in the 9 January test. The commission rejected the defense and ...
Androsterone 19-Noretiocholanolone 5α-Dihydronandrolone 5α-Dihydronorethisterone "THE 2007 PROHIBITED LIST INTERNATIONAL ...
... and androsterone. Androstenol is the putative female pheromone. In a 1978 study by Kirk-Smith, people wearing surgical masks ...
Their research led to Munson and Jones publishing two papers on androsterone and monopalmitin in the Journal of Biological ... She pursued these interests by studying androsterone and monopalmitin at Armour, and cathepsin C at Yale. Jones worked as ...
... androsterone, and estratetraenol. PH94B (Aloradine IN; 4,16-androstadien-3β-ol) is an investigational new drug proposed as an ...
... androsterone, and etiocholanolone. The World Anti-Doping Agency recently released the 2014 Prohibited Substances list and it ...
Its oil has been considered an aphrodisiac, as its aroma has similarity with androsterone, a male hormone. In Ayurvedic ...
1-Androsterone (also known as 1-andro, 1-dehydroepiandrosterone, 1-DHEA, δ1-epiandrosterone, or 5α-androst-1-en-3β-ol-17-one) ... "1-Androsterone": identification as 3β-hydroxy-5α-androst-1-en-17-one and its urinary elimination". Steroids. 76 (6): 540-7. doi ... 4-Dehydroepiandrosterone Androsterone Epiandrosterone Parr MK, Opfermann G, Geyer H, Westphal F, Sönnichsen FD, Zapp J, ...
Androsterone glucuronide (ADT-G) is a major circulating and urinary metabolite of testosterone and dihydrotestosterone (DHT). ... ADT-G is formed from androsterone by UDP-glucuronosyltransferases, with the major enzymes being UGT2B15 and UGT2B17. It is a ... 837-. ISBN 978-1-4557-2758-2. Metabocard for Androsterone Glucuronide (HMDB02829) - Human Metabolome Database v t e v t e. ... 3α-Androstanediol Androsterone sulfate Etiocholanolone glucuronide http://www.hmdb.ca/metabolites/HMDB02829 Jerome F. Strauss, ...
Androsterone glucuronide , C25H38O8 , CID 114833 - structure, chemical names, physical and chemical properties, classification ...
I am 23 and Ive bought 1-Androsterone Liquid. Im a little worried about side effects and pct. My PCT plan: I live in ... 1-Androsterone and using without cycling Hi. This is my first post here.. I am 23 and Ive bought 1-Androsterone Liquid. Im a ... AnabolicMinds.com , Forum , Supplement Forum , Supplements , 1-Androsterone and using without cycling ... 1. What do you think of 1-Androsterone and my PCT plan? Am I gonna get good results? Will Inhibit-e avoid gyno?. 2. What ...
So you would dose it similar to the 1-Androsterone. If you used both 1-Androsterone and Decavol I would probably start the 4-AD ... So you would dose it similar to the 1-Androsterone. If you used both 1-Androsterone and Decavol I would probably start the 4-AD ... This makes 1-Androsterone, a prohormone to 1-Testosterone, a powerful anabolic.. When 1-Androsterone is consumed (via our ... 1-Androsterone or 1-DHEA. Thats pretty good news that 1-testosterone was the second highest metabolite after only 1 cap. Of ...
... (1) ,endocrinology, A male sex hormone, derived from progesterone, which is seven times weaker than ... glossary/androsterone.txt · Last modified: 2012/10/16 14:40 (external edit) ...
THE RESPONSE OF THE CAPONS COMB TO ANDROSTERONE Message Subject (Your Name) has forwarded a page to you from Journal of ... THE RESPONSE OF THE CAPONS COMB TO ANDROSTERONE. D. ROY McCULLAGH and W. KENNETH CUYLER ... THE RESPONSE OF THE CAPONS COMB TO ANDROSTERONE. D. ROY McCULLAGH and W. KENNETH CUYLER ... THE RESPONSE OF THE CAPONS COMB TO ANDROSTERONE. D. ROY McCULLAGH and W. KENNETH CUYLER ...
... buy high quality Androgens Androsterone Prohormone Supplements Androgenic Steroid Powder of Hongkong YuanCheng GongChuang ... Androgens Androsterone Prohormone Supplements Androgenic Steroid Powder Androgens Androsterone Prohormone Supplements ... Androgens Androsterone Prohormone Supplements Androgenic Steroid Powder Androgens Androsterone Androgenic Steroid Powder 99% ... CAS 53-41-8 Androsterone. Product Name: Androsterone. CAS No.: 53-41-8. EINECS:200-173-4. Molecular Formula: C19H30O2. ...
Androsterone sulfate. Description. Androsterone sulfate (Andros-S) is the most abundant 5-alpha-reduced androgen metabolite in ... Androsterone sulfate, sodium salt, (3alpha,5beta)-isomer. MeSH. Androsterone sulfate, sodium salt, (3beta,5alpha)-isomer. MeSH ... Showing metabocard for Androsterone sulfate (HMDB0002759). IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological ... Chang HJ, Shi R, Rehse P, Lin SX: Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone ...
What Makes 1-Androsterone RDe™ the Strongest on the Market. There is literally no other true product in the muscle building ... How Does 1-Androsterone RDe™ Work. With its superior bioavailability and absorption Matrix, RDe™ helps to deliver the active 1- ... What is 1-Androsterone RDe™. A powerful naturally occurring (dietary ingredient) metabolite of DHEA combined with a ... Androsterone RDe™ hormone (1-Androstene-3b-ol, 17-one) to the skeletal muscle tissue where enzymes convert 1-Androstene-3b-ol, ...
... buy high quality 3B Androsterone Pharmaceutical Intermediate Epiandrosterone CAS 481-29-8 of Hubei XinRunde Chemical Co., Ltd ... 3B Androsterone Pharmaceutical Intermediate Epiandrosterone CAS 481-29-8 3B Androsterone Pharmaceutical Intermediate ... Epiandrosterone and Androsterone. are very closely related. Androsterone is the 3-alpha isomer and epiandrosterone is the 3- ... 3B Androsterone Pharmaceutical Intermediate Epiandrosterone CAS 481-29-8 3B Androsterone Pharmaceutical Intermediate ...
An internal standard suitable for LC/MS or GC/MS applications with androsterone and androsterone glucuronide such as diagnostic ... Androsterone-D4 glucuronide, A-099 100 ug/mL in Methanol ... added value in allowing for quantitation of androsterone ... Cerilliant introduces a Certified Spiking Solution® of its latest hormone internal standard, Androsterone-D4 glucuronide. ...
Androsterone (UNII: C24W7J5D5R) (Androsterone - UNII:C24W7J5D5R). Androsterone. 31 [kp_C] in 1 mL. ... Formula Ingredients Dilution Androsterone (31K), Artichoke (31K), ATP (31K), bFGF (4C, 201K), cAMP (31K), L-Carnitine (31K), ... androsterone, artichoke, atp, bfgf, camp, l-carnitine, centella asiatica, citric acid, cobalt, estrogen, ferrum fumaricum, ... VIATREXX-CELLULITE- androsterone, artichoke, atp, bfgf, camp, l-carnitine, centella asiatica, citric acid, cobalt, estrogen, ...
Androsterone (UNII: C24W7J5D5R) (Androsterone - UNII:C24W7J5D5R). Androsterone. 200 [kp_C] in 1 mL. ... Label: MALE PLUS - bos taurus adrenal gland, sus scrofa adrenal gland, aldosterone, androsterone, adenosine cyclic 3,5- ... MALE PLUS - bos taurus adrenal gland, sus scrofa adrenal gland, aldosterone, androsterone, adenosine cyclic 3,5-phosphate, ... MALE PLUS - bos taurus adrenal gland, sus scrofa adrenal gland, aldosterone, androsterone, adenosine cyclic 3,5-phosphate, ...
Genetic deficiency of androsterone UDP-glucuronosyltransferase activity in Wistar rats is due to the loss of enzyme protein M ... The transferase that conjugates both androsterone and testosterone was eluted at about pH 8.0, had subunit Mr values of 50 000 ... M Matsui, F Nagai; Genetic deficiency of androsterone UDP-glucuronosyltransferase activity in Wistar rats is due to the loss of ... Studies on the genetic linkage of bilirubin and androsterone UDP-glucuronyltransferases by cross-breeding of two mutant rat ...
In contrast, androsterone activated UGT1A8 activity. Overall, these data demonstrate that amitriptyline, androsterone, ... Inhibition of 4MU or TFP Glucuronidation by Drugs and Other Chemicals. Amitriptyline, androsterone, canrenoic acid, hecogenin, ... Amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone are nonselective ... Incubations with these enzymes contained 1% methanol (v/v) for the dissolution of androsterone, canrenoic acid, phenylbutazone ...
trans-androsterone, epiandrosterone. TAM. tamoxifen. LTG. lamotrigine. HPLC. high-performance liquid chromatography. ESI. ... To characterize the glucuronidation kinetics of DHT and t-AND in the absence of a modifier, trans-androsterone glucuronide and ... Both trans-androsterone glucuronide and dihydrotestosterone glucuronide eluted at 7.10 min, and the internal standard ... To this end, two positional isomers, dihydrotestosterone (DHT) and trans-androsterone (t-AND), were used as probe substrates, ...
Re: Low morning cortisol, very low DHEA, low Androsterone, low progesterone. Advertisement. Beautiful Skin From Powerful Oils ...
Androsterone glucuronide (ADG) is a major metabolite of the androgen dihydrotestosterone and has also been shown to arise from ... Reference range data on androsterone glucuronide in healthy male and female volunteers and clinical uses of the assay. Joanne ... Reference range data on androsterone glucuronide in healthy male and female volunteers and clinical uses of the assay (. ... the intracrine conversion of other adrenal androgens such as androstenedione and androsterone. ADG has been shown to be raised ...
... Pribbenow, Susanne; ... Measuring faecal epi-androsterone as an indicator of gonadal activity in spotted hyenas (Crocuta crocuta). Login ...
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Androsterone can be reversibly converted to 3a-Androstanediol and then to testosterone . Androsterone and its metabolites are ... Androsterone is excreted into the urine as Androstrone Glucuronide and Androsterone Sulfate and also metabolized to 11b- ... Androsterone( ADT ) is produced from both adrenal and gonadal glands . Androsterone is a 17-Ketosteroid possessing potent ... Kream J ,Hellman L,Rosenfield RS(1976) Radioimmunoassay of androsterone and androsterone -3-sulfate in plasma .Steroids 27:727- ...
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  • Androsterone glucuronide (ADT-G) is a major circulating and urinary metabolite of testosterone and dihydrotestosterone (DHT). (wikipedia.org)
  • Cerilliant introduces a Certified Spiking Solution® of its latest hormone internal standard, Androsterone-D 4 glucuronide. (cerilliant.com)
  • An internal standard suitable for LC/MS or GC/MS applications with androsterone and androsterone glucuronide such as diagnostic testing for diagnosis and treatment of gonadal and adrenal diseases or sports testing to monitor testosterone doping. (cerilliant.com)
  • This Certified Spiking Solution ® provides added value in allowing for quantitation of androsterone glucuronide levels by LC-MS/MS without the need for hydrolysis. (cerilliant.com)
  • Androsterone glucuronide (ADG) is a major metabolite of the androgen dihydrotestosterone and has also been shown to arise from the intracrine conversion of other adrenal androgens such as androstenedione and androsterone. (endocrine-abstracts.org)
  • Androsterone is present in blood in its free (unconjugated) form and as its Glucuronide and Sulfate derivatives. (panlaboratories.com)
  • Androsterone is excreted into the urine as Androstrone Glucuronide and Androsterone Sulfate and also metabolized to 11b-HydroxyAndrostrone and 11-ketoAndrosterone. (panlaboratories.com)
  • To address these questions, we measured two hormonal indices of 5α-reductase activity [serum levels of androstane-3α-17β-diol glucuronide (3α-diol G) and androsterone glucuronide (AG)] in healthy, older African-American, white, and Asian-American men, who are at high, intermediate, and low prostate cancer risk, respectively. (aacrjournals.org)
  • Here are 5 most popular pheromone items: Chikara Cologne Originally called Chikara 7, after the variety of scent compounds, this item consists of the three pheromones found in most scent items: androstenol, androstenone and androsterone, in addition to 4 brand-new components never ever before used in perfumery. (paxwa.com)
  • Here are five most popular pheromone products: Chikara Cologne Originally named Chikara 7, after the number of pheromone compounds, this product contains the three pheromones found in most pheromone products: androstenol, androstenone and androsterone, as well as four new ingredients never before used in perfumery. (createmybb3.com)
  • Often with as hard as the words are to spell they often get misspelled, for instance Androstenone and Androsterone. (pheromoneadvantage.com)
  • Let me clear up for you really quick the differences between Androstenone and Androsterone. (pheromoneadvantage.com)
  • Androsterone is one of the androgens, which are steroid hormones that affect the masculinization of the fetus and child and that maintain or create masculine traits in adults. (chinacomputerparts.com)
  • This is fascinating because the androgens in which Androsterone is derived from are often associated with hyperlipidemic states (elevated cholesterol). (socal-nutrition.com)
  • Androsterone is a chemical byproduct created during the breakdown of androgens, or derived from progesterone , that also exerts minor masculinising effects, but with one-seventh the intensity of testosterone. (wikipedia.org)
  • 1-Androsterone (also known as 1-andro, 1-dehydroepiandrosterone, 1-DHEA, δ1-epiandrosterone, or 5α-androst-1-en-3β-ol-17-one) is a synthetic, orally active anabolic-androgenic steroid (AAS). (wikipedia.org)
  • 1-Androsterone (chemical name: 1-DHEA), converts to three different powerful hormones. (anabolicminds.com)
  • In women with depression being treated with DHEA, the response rate was directly correlated with androsterone levels. (raypeatforum.com)
  • 1-Androsterone, or 1-DHEA, may appear under the nomenclature 1-androsten-3b-ol-17-one. (passionchemical.com)
  • 1-androsterone (aka 1-DHEA) is a prohormone that undergoes a two step conversion through the enzymes 3b-hsd and 17b-hsd to become the potent androgen 1-Testosterone. (foodmate.com)
  • This makes 1-Androsterone, a prohormone to 1-Testosterone, a powerful anabolic. (anabolicminds.com)
  • This way you have more 1-Androsterone converting to the powerful 1-Testosterone, helping to build more muscle. (anabolicminds.com)
  • A molecule of androsterone is very similar to testosterone. (chinacomputerparts.com)
  • With its superior bioavailability and absorption Matrix, RDe™ helps to deliver the active 1-Androsterone RDe™ hormone (1-Androstene-3b-ol, 17-one) to the skeletal muscle tissue where enzymes convert 1-Androstene-3b-ol, 17-one via a 2-step conversion pathway to the target hormone 1-Testosterone. (vitanatural.net)
  • Hepatic microsomal UDP-glucuronosyltransferases towards androsterone and testosterone were purified by chromatofocusing and UDP-hexanolamine affinity chromatography in Wistar rats which had genetic deficiency of androsterone UDP-glucuronosyltransferase activity. (portlandpress.com)
  • In rats with the high-activity phenotype, androsterone (the 3-hydroxy androgen) UDP-glucuronosyltransferase was eluted at about pH 7.4 and had a subunit Mr of 52 000, whereas testosterone (the 17-hydroxy steroid) UDP-glucuronosyltransferase was eluted at about pH 8.4 and had a subunit Mr of 50 000. (portlandpress.com)
  • The transferase that conjugates both androsterone and testosterone was eluted at about pH 8.0, had subunit Mr values of 50 000 and 52 000, and appeared to be an aggregate or hybrid of androsterone and testosterone UDP-glucuronosyltransferases. (portlandpress.com)
  • In rats with the low-activity phenotype, androsterone UDP-glucuronosyltransferase was absent, whereas testosterone UDP-glucuronosyltransferase was eluted at around pH 8.5, with a subunit Mr of 50 000. (portlandpress.com)
  • 1-Androsterone is currently available over the counter, and is contained in Iron Mag Labs 1-Andro-Rx, Advanced Muscle Science 1-Androsterone RD, and Primordial Performance 1-T. 1-Androsterone is a true prohormone, converting to 1-testosterone (dihydroboldenone). (passionchemical.com)
  • Orally, 1-Androsterone has about a 10% conversion rate to 1-testosterone. (passionchemical.com)
  • Glucuronidation of androsterone and testosterone was highly significant and increased from proximal to distal intestine. (nih.gov)
  • High levels of UGT protein were detected with polyclonal anti-rat androsterone- and testosterone-UGT antibodies, whereas UGT2B4, a major hepatic hyodeoxycholic acid-specific UGT, was undetectable using a highly specific anti-human UGT2B4 antibody. (nih.gov)
  • To our knowledge, the presence of functional androsterone and testosterone directed isoforms in human intestine is a novel finding which supports the idea that the intestinal tract functions as a steroid-metabolizing organ and plays a significant role in steroid hormone biotransformation. (nih.gov)
  • 8380602 ). Androsterone sulfate is clinically recognized as one of the major androgen metabolites found in urine. (hmdb.ca)
  • Kream J ,Hellman L,Rosenfield RS(1976) Radioimmunoassay of androsterone and androsterone -3-sulfate in plasma .Steroids 27:727-739. (panlaboratories.com)
  • Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. (chinacomputerparts.com)
  • There is literally no other true product in the muscle building supplement category on the market that converts via the 2-step process to the powerful target hormone like 1-Androsterone RDe™ does. (vitanatural.net)
  • 2 . Epiandrosterone, or 3β -androsterone, also known as 3β -hydroxy-5α -androstan-17-one or 5α - androstan-3β -ol-17-one, is a steroid hormone with weak androgenic activity. (chinacomputerparts.com)
  • Research shows that the sex hormone Androsterone has the capabilities to lower bad cholesterol (LDL), and increase oxygen consumption similar to active thyroid hormone (T3). (socal-nutrition.com)
  • However, following the Androsterone treatment, after cessation of the steroid hormone, serum cholesterol concentrations returned to pre-treatment levels EXCEPT in the patient with hypothyroidism (low thyroid). (socal-nutrition.com)
  • Patients that had low and normal thyroid functions underwent cytomel (prescription T3 hormone) treatment, they produced both an absolute and relative INCREASE in Androsterone levels. (socal-nutrition.com)
  • Androsterone, Male Hormone, Steroids manufacturer / supplier in China, offering White Crystalline Muscle Building Steroids Powder Androsterone 53-41-8, Nandrolone Phenypropionate Muscle Growth Anabolic Steroid Nand Pheny 62-90-8, Mupirocin CAS 12650-69-0 Bactroban Powder for Skin Infections Treatment and so on. (made-in-china.com)
  • Researchers looking for a real turn-on tonic have focused on the potent male hormone androsterone, which is also found in celery. (menshealth.com)
  • 1.) Skovasted, J. Molholm Hansen , M. Kristernsen and L Korsgaard Christensen, The androsterone-etiocholanolone extretion ratio in Hyper- and Hypothyroidism . (socal-nutrition.com)
  • They are all completely different - some products contain androstenol or androsterone, and others contain androstenone and copulins. (pheremones.info)
  • This product contains androstenol and androsterone. (greencoffee800mg.com)
  • Epiandrosterone and Androsterone are very closely related. (chinacomputerparts.com)
  • Androsterone is the 3-alpha isomer and epiandrosterone is the 3-beta isomer of this compound. (chinacomputerparts.com)
  • Most epiandrosterone supplements are actually a mix of the two isomers, meaning that they contain some androsterone as well as the main ingredient epiandrosterone. (chinacomputerparts.com)
  • This narrows down the list of possible 'suspects' to just a few steroids and one of them is androsterone. (raypeatforum.com)
  • Thyroid also treats dementia and androsterone is probably one of the most pro-thyroid steroids. (raypeatforum.com)
  • Because 1-Androsterone is non-methylated, it can be stacked with methylated steroids or prohormones without putting additional stress on the liver. (passionchemical.com)
  • Androsterone is an endogenous steroid and since it is excreted in high concentrations in urine, it was used as a representative of anabolic steroids. (cut.ac.za)
  • High doses of probenecid inhibit the urinary excretion of androsterone and therefore it will also inhibit the excretion of other anabolic steroids excreted as glucuronides in urine. (cut.ac.za)
  • Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. (genecards.org)
  • Androsterone is a 17-Ketosteroid possessing potent androgenic activity. (panlaboratories.com)
  • Given that androsterone is also a potent GABA agonist just like allopregnanolone virtually points the finger straight at that steroid as the main mechanism of DHEA's antidepressant action. (raypeatforum.com)
  • Of the three tap water samples analyzed, estradiol and androsterone were detected in tap water in laboratories in France and Spain, while corticosterone was detected in the water sample from the Chinese laboratory. (sigmaaldrich.com)
  • Androsterone pheromone can be bought in a concentrate form or mixed with a fragrant cologne. (forumotion.com)
  • A survey of 100 men who used a popular brand of androsterone pheromone concentrate reported the following: Aiming high is our motto when writing about any topic. (forumotion.com)
  • A survey of 100 men who used a popular brand of androsterone pheromone concentrate reported the following: We tried to create as much matter for your understanding when writing on Pheromones. (userboard.org)
  • androsterone pheromone concentrate - What Are the Most Popular Pheromones? (pheromone-for-men.info)
  • Androsterone, CAS No.: 53-41-8, Steriod manufacturer / supplier in China, offering Purity 98% Androsterone CAS No.: 53-41-8, Methyl Ionone 127-51-5 with Competitive Price, 2322-77-2 High Purity 13-Ethyl-3-Methoxy-Gona-2, 5 (10) -Dien-17-One 90% and so on. (made-in-china.com)
  • Patients with HYPERthyroidism (over-active thyroid) displayed higher endogenous Androsterone levels. (socal-nutrition.com)
  • In men, androgenic hormones decline in the aging process, therefore, it may be in a male's best interest to supplement with Androsterone to defend against atherosclerosis (clogged arteries), and a compromised rate of oxygen consumption due to decreased thyroid output. (socal-nutrition.com)
  • When 1-Androsterone is consumed (via our cyclodextrin based orally disintegrating tablets), it comes in contact with various tissues throughout the body (blood, fat, muscle, liver, etc) (1-3). (anabolicminds.com)
  • Androsterone (ADT) in serum and plasma is extracted with a mixture of hexane / ethyl acetate before drying under nitrogen. (panlaboratories.com)
  • Dihydrotestosterone (DHT) and trans- androsterone ( t -AND) ( Fig. 1 ) are two steroidal substrates of UGT1A4. (aspetjournals.org)
  • Therefore, the pathway can be outlined as 17α-hydroxyprogesterone (17-OHP) → 5α-pregnan-17α-ol-3,20-dione (17‐OH-DHP) → 5α-pregnane-3α,17α-diol-20-one (5α-pdiol) → 5α-androstan-3α-ol-17-one (androsterone) → 5α-androstane-3α,17β-diol (3α-diol) → 5α-dihydrotestosterone (wikiversity.org)
  • Screening for RNA expression by RT-PCR confirmed the absence of UGT2B4 and UGT1A6 and showed expression of UGT2B7, a hepatic isoform shown to glucuronidate androsterone, in all intestinal segments. (nih.gov)
  • Decreased levels of Androsterone are seen in many cancer patients and people with myxedema. (panlaboratories.com)
  • Androsterone was originally isolated from male urine in very small amounts. (chinacomputerparts.com)
  • After administration urine collections were made at predetermined intervals over a peroid of 48 hours for the determination of androsterone and probenecid concentrations. (cut.ac.za)
  • People with hypothyroidism (low thyroid) are characterized by an absolute and relative DECREASE in Androsterone levels. (socal-nutrition.com)
  • Elevated levels of Androsterone tend to have a cholesterol lowering effect and male sexual charecteristics , including male baldness. (panlaboratories.com)
  • It is clear that Androsterone demonstrates a thyromimetic characteristic due to increasing a person's rate of oxygen consumption , which in turn can also lower cholesterol levels. (socal-nutrition.com)
  • Androsterone is pretty exciting because it seems to be a possible treatment for people displaying hypercholesteremia (elevated cholesterol) symptoms. (socal-nutrition.com)
  • A pilot study performed at the F ARMOVS Research Centre, Department of Pharmacology, Bloemfontein suggested a significant decrease on the urinary excretion of androsterone after the intake of probenecid. (cut.ac.za)
  • It's use as a pheromone is born out of the fact that males with a higher ratio of Androsterone to Etiocholanone are more masculine. (chinacomputerparts.com)
  • Thus, androsterone makes the wearer appear to be more masculine and/or dominant, but without the aggression of androstenone. (chinacomputerparts.com)
  • Androsterone is a masculine pheromone. (greencoffee800mg.com)
  • Many men have reported using the androsterone pheromone in sports or business environments to be noticed and gain respect. (forumotion.com)
  • A statistically significant decrease in the excretion rate of androsterone was seen from 2 to 8 hours after administration of a single dose of probenecid (4 x 500mg). (cut.ac.za)
  • 1 - Androsterone RDe is a natural supplement that works to enhance strength and endurance to help with building muscle. (venez.fr)
  • Some of this evidence comes from a study at the University of Kentucky when researchers sprayed the male pheromone, androsterone on pictures of men of average sexual attractiveness. (forumotion.com)
  • We have determined the crystal structures of a binary complex with NAD(+) and a ternary complex with androsterone and NADH. (rcsb.org)
  • Moderate gains of muscle mass and strength can be expected .Elevated levels of Androsterone are frequently seen in female patients with acne with or without hirsutism. (panlaboratories.com)
  • 1-Androsterone is great for gains in both strength and size. (passionchemical.com)
  • The steroid (androsterone), in a single daily dosage of 50 mgs was given intra-muscularly in sesame oil & benzyl alcohol. (socal-nutrition.com)
  • ADT-G is formed from androsterone by UDP-glucuronosyltransferases, with the major enzymes being UGT2B15 and UGT2B17. (wikipedia.org)
  • When showed to women, it was discovered that men in the androsterone-sprayed pictures were rated as more attractive. (forumotion.com)
  • h2]81% Reported Being Approached by Women They Didn't Know[/h2]68% reported an increase in dates and other forms of sociosexual contact Androsterone pheromone also seems to have an affect on other men, making someone who has more seem more intimidating. (userboard.org)