Androstenediol: An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).Androstenediols: Unsaturated androstane derivatives which are substituted with two hydroxy groups in any position in the ring system.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.Portal Pressure: The venous pressure measured in the PORTAL VEIN.Portal System: A system of vessels in which blood, after passing through one capillary bed, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system.Shock, Hemorrhagic: Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Doping in Sports: Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.Performance-Enhancing Substances: Agents that improve the ability to carry out activities such as athletics, mental endurance, work, and resistance to stress. The substances can include PRESCRIPTION DRUGS; DIETARY SUPPLEMENTS; phytochemicals; and ILLICIT DRUGS.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Athletic Performance: Carrying out of specific physical routines or procedures by one who is trained or skilled in physical activity. Performance is influenced by a combination of physiological, psychological, and socio-cultural factors.Substance Abuse Detection: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.Hydroxysteroid Dehydrogenases: Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.3-Hydroxysteroid Dehydrogenases: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.Leydig Cells: Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Education, Pharmacy, Continuing: Educational programs designed to inform graduate pharmacists of recent advances in their particular field.Famous PersonsInternet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Fraxinus: A plant genus of the family OLEACEAE. Members contain secoiridoid glucosides.Trenbolone Acetate: An anabolic steroid used mainly as an anabolic agent in veterinary practice.Anabolic Agents: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.Nandrolone: C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.Drug Implants: Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.Zeranol: A non-steroidal estrogen analog.Women's Health: The concept covering the physical and mental conditions of women.Menopause: The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.Complementary Therapies: Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (PHYSICAL THERAPY MODALITIES; DIET; ACUPUNCTURE) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment.Anseriformes: An order of BIRDS comprising the waterfowl, particularly DUCKS; GEESE; swans; and screamers.Ethnic Groups: A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships.Longitudinal Studies: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.Gynostemma: A plant genus of the family CUCURBITACEAE. It is a source of gypenosides and triterpenoid SAPONINS.Nasal Decongestants: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)Stifle: In horses, cattle, and other quadrupeds, the joint between the femur and the tibia, corresponding to the human knee.Ephedra: A plant genus of the family Ephedraceae, order Ephedrales, class Gnetopsida, division Gnetophyta.Adrenal Glands: A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.Benzphetamine: A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)Fetus: The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.Adrenal Cortex: The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Aldosterone: A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.Adrenal Gland Neoplasms: Tumors or cancer of the ADRENAL GLANDS.Fatty Alcohols: Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Alcoholic Beverages: Drinkable liquids containing ETHANOL.Alcohol Drinking: Behaviors associated with the ingesting of alcoholic beverages, including social drinking.Waxes: A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Sjogren-Larsson Syndrome: An autosomal recessive neurocutaneous disorder characterized by severe ichthyosis MENTAL RETARDATION; SPASTIC PARAPLEGIA; and congenital ICHTHYOSIS. It is caused by mutation of gene encoding microsomal fatty ALDEHYDE DEHYDROGENASE leading to defect in fatty alcohol metabolism.Alcohols: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicity. (1/60)

The protective effects of the hormones androstenediol (androstene-3beta, 17beta,-diol; AED) and dehydroepiandrosterone (5-androsten-3beta-ol-17-one; DHEA) on the pathophysiology of two lethal bacterial infections and endotoxin shock were examined. The infections included a gram-positive organism (Enterococcus faecalis) and a gram-negative organism (Pseudomonas aeruginosa). Both hormones protected mice from the lethal bacterial infections and from lipopolysaccharide (LPS) challenge. Treatment of animals lethally infected with P. aeruginosa with DHEA resulted in a 43% protection whereas treatment with AED gave a 67% protection. Both hormones also protected completely animals infected with an LD50 dose of E. faecalis. Similarly, the 88% mortality rate seen in LPS challenge was reduced to 17% and 8.5%, by treatment with DHEA and AED, respectively. The protective influences of both steroids were shown not to be directly antibacterial, but primarily an indirect antitoxin reaction. DHEA appears to mediate its protective effect by a mechanism that blocks the toxin-induced production of pathophysiological levels of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1. AED usually had greater protective effects than DHEA; however, the AED effect was independent of TNF-alpha suppression, both in vivo and in vitro. The data suggest that both DHEA and AED may have a role in the neuro-endocrine regulation of antibacterial immune resistance.  (+info)

Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells. (2/60)

Our earlier report suggested that androst-5-ene-3beta,7beta-diol (Delta(5)-androstenediol or Adiol) is a natural hormone with androgenic activity and that two potent antiandrogens, hydroxyflutamide (Eulexin) and bicalutamide (Casodex), fail to block completely the Adiol-induced androgen receptor (AR) transactivation in prostate cancer cells. Here, we report the development of a reporter assay to screen several selective steroids with anti-Adiol activity. Among 22 derivatives/metabolites of dehydroepiandrosterone, we found 4 steroids [no. 4, 1,3,5(10)-estratriene-17alpha-ethynyl-3, 17beta-diol; no. 6, 17alpha-ethynyl-androstene-diol; no. 8, 3beta, 17beta-dihydroxy-androst-5-ene-16-one; and no. 10, 3beta-methylcarbonate-androst-5-ene-7,17-dione] that have no androgenic activity and could also block the Adiol-induced AR transactivation in prostate cancer PC-3 cells. Interestingly, these compounds, in combination with hydroxyflutamide, further suppressed the Adiol-induced AR transactivation. Reporter assays further showed that these four anti-Adiol steroids have relatively lower glucocorticoid, progesterone, and estrogenic activity. Together, these data suggest some selective steroids might have anti-Adiol activity, which may have potential clinical application in the battle against the androgen-dependent prostate cancer growth.  (+info)

Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha. (3/60)

Estrogens stimulate the proliferation of many breast tumors and cell lines derived from them. Antiestrogens have therefore become a powerful therapeutic agent to treat breast tumors that express estrogen receptor (ER) alpha. In addition, aromatase inhibitors are now used in postmenopausal women to block the in situ conversion of adrenal androgens to estrogens. This approach can only be successful if ER-alpha in a particular tumor is not directly stimulated by adrenal androgens. We have examined this possibility using several different cell lines as model systems: (a) wild-type MCF7 cells, an ER-alpha-dependent human breast cancer cell line; (b) MCF7SH cells, an estrogen-independent MCF7 variant; (c) Ishikawa cells, an ER-alpha-containing human uterine cell line; (d) ER-negative HeLa cells; and (e) budding yeast. Transactivation assays with transfected ER-alpha reporter genes reveal a direct activation of ER-alpha by dehydroepiandrosterone (DHEA), 5alpha-androstene-3beta,17beta-diol, testosterone, and the two nonaromatizable androgens, dihydrotestosterone and 5alpha-androstane-3beta,17beta-diol. The involvement of other steroid receptors could be ruled out with specific antihormones. Moreover, the same set of ligands stimulates the proliferation of the two breast cancer cell lines. At subsaturating and physiologically relevant concentrations of DHEA, DHEA stimulates the proliferation of MCF7SH cells, which correlates with a substantial, albeit submaximal, transcriptional response. Thus, adrenal androgens must also be considered as risk factors in postmenopausal women.  (+info)

Over-the-counter delta5 anabolic steroids 5-androsen-3,17-dione; 5-androsten-3beta, 17beta-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3,17-dione: excretion studies in men. (4/60)

Studies of urinary steroids were performed in males after oral administration of 5-androsten-3,17-dione; 5-androsten-3beta,17beta-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3,17-dione. 5-Androsten-3,17-dione; 5-androsten-3beta,17beta-diol; and dehydroepiandrosterone amplify most endogenous steroids, but to a lesser extent than their delta4 analogues do. Especially affected are androsterone, etiocholanolone, dehydroandrosterone, dehydroepiandrosterone, and isomeric 5-androstendiols. 5-Androsten-3,17-dione; 5-androsten-3beta,17beta-diol; and dehydroepiandrosterone elevate the urinary testosterone to epitestosterone (T/E) ratio by a factor of 2-3 a few hours after administration. This may cause a positive T/E test (> 6) for individuals with normal T/E ratios higher than 2. Most of the steroids return to their original concentrations in less than 24 h. Etiocholanolone and 5beta-androstan-3alpha,17beta-diol remain elevated for several days. A reduced androsterone to etiocholanolone (A/E) ratio may be an indication of delta5 steroids abuse. 19-Nor-5-androsten-3,17-dione has a similar effect, except that all metabolites in urine are 19-nor exogenous steroids. Identification criteria for 19-nor-5-androsten-3,17-dione may be the same as nandrolone, that is, detection of 19-norandrosterone and 19-noretiocholanolone. Specific abundant metabolites of 19-nor-5-androsten-3,17-dione are 19-nordehydroandrosterone and 19-nordehydroepiandrosterone. In the later stages of excretion, higher concentration of 1 9-noreticholanolone relative to 19-norandrosterone specifically indicates administration of 19-nor delta5 steroids.  (+info)

Interactions between hormone-mediated and vaccine-mediated immunotherapy for pulmonary tuberculosis in BALB/c mice. (5/60)

Problems of logistics, compliance and drug resistance point to an urgent need for immunotherapeutic strategies capable of shortening the current 6-month chemotherapy regimens used to treat tuberculosis, or of supplementing ineffective therapy. In this study we sought to define the mechanism of action of two immunotherapies, both of which have previously been shown to prolong survival. Secondly, we wished to identify any clinically useful synergy between these therapies. In BALB/c mice infected via the trachea with Mycobacterium tuberculosis H37Rv there is an initial phase of partial resistance dominated by type 1 cytokines plus tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1), followed by a phase of progressive disease. This progressive phase is accompanied by increasing expression of IL-4, and diminished expression of IL-1 and TNF-alpha. Animals in this late progressive phase of the disease (day 60) were treated with two injections (day 60 and day 90) of 0.1 or 1.0 mg of heat-killed Mycobacterium vaccae, or with 3beta, 17beta-androstenediol (AED; 25 microg subcutaneously three times/week), or with both therapies. We show here using four techniques in parallel (morphometry, immunohistochemistry with automated cell counting, semiquantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assays of cytokines in lung extracts) that treatment with M. vaccae causes a switch back towards a type 1 cytokine profile, restoration of expression of IL-1alpha and TNF-alpha, and a switch from pneumonia to granuloma. This is very similar to the changes previously seen after treatment with AED. However, there was no evidence for synergy between M. vaccae and AED.  (+info)

Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism. (6/60)

Androstenediol (5-androsten-3beta, 17beta-diol, ADIOL) and androstenediol 3-sulfate (ADIOLS) are active metabolites of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS), respectively, and have estrogenic activity and immunoregulatory function. We examined serum concentrations of ADIOL, ADIOLS, DHEA, DHEAS and pregnenolone sulfate (5-pregnen-3beta-ol-20-one sulfate, PREGS) in patients with Graves' thyrotoxicosis (male/female 9/14), hypothyroidism (11/20) and in normal controls (14/29). In hypothyroidism serum levels of all these steroids were significantly decreased in both genders. In hyperthyroidism, in contrast, serum levels of ADIOLS (male 1.49 +/- 0.69, female 0.64 +/- 0.31 micromol/l), DHEAS (male 7.43 +/- 3.91, female 5.13 +/- 2.03 micromol/l), and PREGS (male 1.13 +/- 0.58, female 1.07 +/- 0.85 micromol/l) were markedly increased, but serum concentrations of ADIOL and DEHA were not significantly different from controls (ADIOLS male 0.36 +/- 0.33, female 0.14 +/- 0.09 micromol/l; DHEAS male 2.88 +/- 1.70, female 1.86 +/- l1.03pmol/l; PREGS male 0.18 +/- 0.12, female 0.11 +/- 0.08 micromol/l; ADIOL male 3.76 +/- 1.35, female 1.91 +/- 1.17 nmol/l; DHEA male 9.23 +/- 3.49, female 13.5 +/- 10.8nmol/l). Serum concentrations of all these steroids correlated with the serum concentration of the thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentrations of steroids. These findings indicate that serum concentrations of ADIOLS, ADIOL, DHEAS, DHEA and PREGS were decreased in hypothyroidism, whereas serum ADIOLS, DHEAS and PREGS concentrations were increased but ADIOL and DHEA were normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids and sulfotransferase is speculated to be increased in hyperthyroidism. Increased ADIOLS might contribute to menstrual disturbances and gynecomastia in hyperthyroidism.  (+info)

Acute hormonal response to sublingual androstenediol intake in young men. (7/60)

The effectiveness of orally ingested androstenediol in raising serum testosterone concentrations may be limited because of hepatic breakdown of the ingested androgens. Because androstenediol administered sublingually with cyclodextrin bypasses first-pass hepatic catabolism, we evaluated the acute hormonal response to sublingual cyclodextrin androstenediol supplement in young men. Eight men (22.9 +/- 1.2 yr) experienced in strength training consumed either 20 mg androstenediol in a sublingual cyclodextrin tablet (Sl Diol) or placebo (Pl) separated by at least 1 wk in a randomized, double-blind, crossover manner. Blood samples were collected before supplementation and at 30-min intervals for 3 h after supplementation. Serum hormone concentrations did not change with Pl. Serum androstenedione concentrations were increased (P < 0.05) above baseline (11.2 +/- 1.1 nmol/l) with Sl Diol from 60 to 180 min after intake and reached a peak concentration of 25.2 +/- 2.9 nmol/l at 120 min. Serum free testosterone concentrations were increased from 86.2 +/- 9.1 pmol/l with Sl Diol from 30 to 180 min and reached a peak concentration of 175.4 +/- 12.2 pmol/l at 60 min. Serum total testosterone concentrations increased above basal (25.6 +/- 2.3 nmol/l) from 30 to 180 min with Sl Diol and reached a peak concentration of 47.9 + 2.9 nmol/l at 60 min. Serum estradiol concentrations were elevated (P < 0.05) above baseline (0.08 +/- 0.01 nmol/l) from 30 to 180 min with Sl Diol and reached 0.14 +/- 0.02 nmol/l at 180 min. These data indicate that sublingual cyclodextrin androstenediol intake increases serum androstenedione, free testosterone, total testosterone, and estradiol concentrations.  (+info)

Phenotypic adaptations in human muscle fibers 6 and 24 wk after spinal cord injury. (8/60)

The effects of spinal cord injury (SCI) on the profile of sarco(endo) plasmic reticulum calcium-ATPase (SERCA) and myosin heavy chain (MHC) isoforms in individual vastus lateralis (VL) muscle fibers were determined. Biopsies from the VL were obtained from SCI subjects 6 and 24 wk postinjury (n = 6). Biopsies from nondisabled (ND) subjects were obtained at two time points 18 wk apart (n = 4). In ND subjects, the proportions of VL fibers containing MHC I, MHC IIa, and MHC IIx were 46 +/- 3, 53 +/- 3, and 1 +/- 1%, respectively. Most MHC I fibers contained SERCA2. Most MHC IIa fibers contained SERCA1. All MHC IIx fibers contained SERCA1 exclusively. SCI resulted in significant increases in fibers with MHC IIx (14 +/- 4% at 6 wk and 16 +/- 2% at 24 wk). In addition, SCI resulted in high proportions of MHC I and MHC IIa fibers with both SERCA isoforms (29% at 6 wk and 54% at 24 wk for MHC I fibers and 16% at 6 wk and 38% at 24 wk for MHC IIa fibers). Thus high proportions of VL fibers were mismatched for SERCA and MHC isoforms after SCI (19 +/- 3% at 6 wk and 36 +/- 9% at 24 wk) compared with only ~5% in ND subjects. These data suggest that, in the early time period following SCI, fast fiber isoforms of both SERCA and MHC are elevated disproportionately, resulting in fibers that are mismatched for SERCA and MHC isoforms. Thus the adaptations in SERCA and MHC isoforms appear to occur independently.  (+info)

Relate products of Androstenediol Androstenediol. Androstenediol Product name:Androstenediol. Androstenediol. M1,4ADD is a prohormone that is proclamied to convert to the steroid
An intermediate in testosterone biosynthesis, found in the testis or the adrenal glands. Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), is converted to testosterone by...
19-Nor-5-androstenediol, 19-nor-5-androstenedione, and other 19-norandrostane prohormones were considered to be nutritional supplements and were sold over-the-counter in the United States as a result of the Dietary Supplement Health and Education Act of 1994 (DSHEA).[1][2] However, they were banned from sports in 1999 by the International Olympic Committee (IOC) and are currently on the World Anti-Doping Agency (WADA) list of prohibited substances.[1] In 2004, they became controlled substances in the U.S. as a result of the Anabolic Steroid Control Act of 2004.[1]. ...
b. Endogenous** AAS when administered exogenously: androstenediol (androst-5-ene-3 ,17 -diol); androstenedione (androst-4-ene-3,17-dione); dihydrotestosterone (17 -hydroxy-5 -androstan-3-one) ; prasterone (dehydroepiandrosterone, DHEA); testosterone and the following metabolites and isomers: 5 -androstane-3 ,17 -diol; 5 -androstane-3 ,17 -diol; 5 -androstane-3 ,17 -diol; 5 -androstane-3 ,17 -diol; androst-4-ene-3 ,17 -diol; androst-4-ene-3 ,17 -diol; androst-4-ene-3 ,17 -diol; androst-5-ene-3 ,17 -diol; androst-5-ene-3 ,17 -diol; androst-5-ene-3 ,17 -diol; 4-androstenediol (androst-4-ene-3 ,17 -diol); 5-androstenedione (androst-5-ene-3,17-dione); epi-dihydrotestosterone; epitestosterone; 3 -hydroxy-5 -androstan-17-one; 3 -hydroxy-5 -androstan-17-one; 19-norandrosterone; 19-noretiocholanolone. [Comment to class S1.1b: Where an anabolic androgenic steroid is capable of being produced endogenously, a Sample will be deemed to contain such Prohibited Substance and an Adverse Analytical Finding will ...
Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA) and of estrone. It is closely related to androstenediol (androst-5-ene-3β,17β-diol). Androstenedione is a precursor of testosterone and other androgens, as well as of estrogens like estrone, in the body. In addition to functioning as an endogenous prohormone, androstenedione also has weak androgenic activity in its own right. Androstenedione has been found to possess some estrogenic activity, similarly to other DHEA metabolites. However, in contrast to androstenediol, its affinity for the estrogen receptors is very low, with less than 0.01% of the affinity of estradiol for both the ERα and ERβ. In children aged 6 to 8 years old, there is a rise in androstenedione secretion along with DHEA during adrenarche. This rise in androstenedione and DHEA is ...
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Sustanon 250® is a Patented Prohormone and Testosterone Booster designed for the purpose of delivering the maximum number and dosage of anabolic compounds in their most bioavailable form, in one tablet. Sustanon 250® contains 150mg of four derivatives of the legal prohormone 4-androsten-3β-ol-17-one, which is the highest dose found anywhere! 4-androsten-3β-ol-17-one (4-Andro) is a precursor to 4-Androstenediol and 4-Androstenedione, which is a precursor to testosterone. Hi-Tech Pharmaceuticals has, once again, incorporated Cyclosome® Technology pharmaceutical manufacturing know-how to thrust bodybuilding supplementation to a new level.
HSD17B1: Referred to as "estrogenic". Major subtype for activation of estrogens from weaker forms (estrone to estradiol and 16α-hydroxyestrone to estriol). Catalyzes the final step in the biosynthesis of estrogens. Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion of DHEA into androstenediol.[10] Recently, has been found to inactivate DHT into 3α- and 3β-androstanediol.[10][11] Expressed primarily in the ovaries and placenta but also at lower levels in the breast epithelium.[12][10] Major isoform of 17β-HSD in the granulosa cells of the ovaries.[13] Mutations and associated deficiency have not been reported in humans.[14] Knockout mice show altered ovarian sex steroid production, normal puberty, and severe subfertility due to defective luteinization and ovarian progesterone production.[15] ...
As part of the testosterone pathway, we chose to include genes involved in the formation of androstenediol and testosterone, because although they are made in the testes, they are also formed from DHEA produced by the adrenal glands and then undergo intracrine conversion to both androgens and estrogens in local tissues.12 We generated a custom SNP panel derived from 16 genes across 12 chromosomes comprising the testosterone metabolic pathway, as depicted in the Figure. We submitted the P values from SNPs within 50 kB of the start and end sites of these genes to PARIS (v2.4).23 We have previously described PARIS23,24 and used a prior version of this software to assess the estrogen metabolism pathway gene variants in relation to POAG.15 PARIS derives a P value for association between a given gene variant set and outcome of interest using a permutation procedure. Specifically, it first creates a random collection of SNPs with genomic features that mimic features of the user-defined pathway (in this ...
Brutal 4ce is a 4-DHEA product that has been destined by force. It is a 2-step precursor which first converts to androstenediol, then to androstenedione, and then to testosterone. Brutal 4ce is a pro anabolic precursor that is not liver toxic and will
The present invention provides an improved means for regulating the immune response, for ameliorating effects of stress, and for avoiding untoward effects of chemotherapy or exposure to irradiation by administration of androstenediol (AED) and androstenetriol (AET). The improved means of regulating immune response can be utilized in treating infectious diseases and immune diseases such as diabetes and chronic fatigue syndrome, both diseases now considered to be immune response related syndromes.
One of 30 tumors showed complete response (CR), 15 showed partial response (PR) and 14 showed stable disease (SD). All treatments were well tolerated. After treatment, a decrease of progesterone receptor expression was more frequent in responding tumors (93.8%) than in non-responding tumors (35.7%). Suppression of Ki67 after treatment was significantly greater in responding tumors than in non-responding tumors (P = 0.002). The mean BC tissue levels of E1, E2, E1S, ADIOL, and AONE at base line were 0.534, 0.409, 0.13, 1.65, and 6.09 pmol/g, respectively. After neoadjuvant therapy, the levels of E1, E2, E1S, ADIOL, and AONE were 0.002, 0008, 0.002, 2.22, and 5.63 pmol/g, respectively. The mean plasma levels of E1, E2, E1S, ADIOL, and AONE at base line were 621.5, 27.0, 1799.5, 1033, and 2258 pmol/l, respectively. After therapy, the levels of E1, E2, E1S, ADIOL, and AONE were 1.7, 1.6, 3.4, 1111, and 2826 pmol/l, respectively. LET significantly suppressed estrogens. Although plasma and tissue ADIOL ...
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The benefits of exercise on cognition have been demonstrated both in animals and humans. Exercise has salutary effects on glucoregulation and visceral adiposity, an important link for adults with impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). Exercise also upregulates neurotrophic activity, an effect that serves to increase neuronal viability in the same brain regions that support complex cognitive functions affected by metabolic disease. In this proposed controlled intervention trial, the hypothesis is that aerobic exercise will have a beneficial effect on cognition and several biomarkers that index disease progression for older adults with IGT. 40 older subjects (age: ,55 yrs) with IGT, confirmed by OGTT, will be randomized to an aerobic fitness or stretching program for 6 months. Cognitive measures and fasting blood samples will be obtained at baseline, month 3, and month 6. Cognitive tests will evaluate abilities affected by age and by significant glucoregulatory ...
102848-54-4 - JIKFCHILHFFTSH-NRIFOQJISA-N - 4-Hydroxy-4-androstene-3,17-dione glucuronide - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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PRIMARY OBJECTIVES:. I. To determine the rate of pathologic complete response in patients with localized prostate cancer treated with androgen depletion therapy (ADT) and oral vorinostat administered for a minimum of 6 weeks and maximum of 8 weeks before radical prostatectomy.. SECONDARY OBJECTIVES:. I. To determine and evaluate pre- and post-treatment levels of prostate-specific antigen (PSA), testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and dehydroepiandrosterone-dulfate (DHEA-S) in blood.. II. To determine and evaluate pre- and post-treatment levels of testosterone, androstenedione, androstenediol, DHT, DHEA, and DHEA-S in prostate.. III. To determine and evaluate gene and protein expression analysis including androgen receptor (AR) target genes, PSA and TMPRSS2 (transmembrane protease, serine 2), in pre-treatment biopsy and post-treatment radical prostatectomy.. IV. To determine and evaluate exploratory gene microarray analysis. V. To determine and evaluate the ...
Testosterone and estradiol circulate in the bloodstream, loosely bound mostly to serum albumin (~54%), and to a lesser extent bound tightly to SHBG (~44%). Only a very small fraction of about 1 to 2% is unbound, or "free," and thus biologically active and able to enter a cell and activate its receptor. SHBG inhibits the function of these hormones. Thus, bioavailability of sex hormones is influenced by the level of SHBG. The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) , testosterone , androstenediol , estradiol , estrone.[2] DHT binds to SHBG with about 5 times the affinity of testosterone and about 20 times the affinity of estradiol.[3] Dehydroepiandrosterone (DHEA) is weakly bound to SHBG, but dehydroepiandrosterone sulfate is not bound to SHBG.[2] Androstenedione is not bound to SHBG either, and is instead bound solely to albumin.[4] Estrone sulfate and estriol are also poorly bound by SHBG.[5] Less than 1% of progesterone is bound to SHBG.[6] SHBG ...
Stress dramatically increases the need for vitamin C, especially in the adrenal glands. Adrenal C Formula created by Dr. James Wilson is a sustained release, pH balanced vitamin C complex that neutralizes the excess acidity of ascorbic acid and delivers the specific trace minerals and bioflavonoids the body needs to fully utilize vitamin C and recover from stress.. Additional Prioduct Information:. Dr. Wilson created Adrenal C Formula especially for stressful lives. Its sustained-release, antioxidant complex of buffered vitamin C, bioflavonoids, and trace minerals provides the vitamin C your stressed body needs in the form it can use best.. * This is a unique vitamin C formulated specifically to support the body during stress and aid in stress recovery, and it also makes an outstanding all-around vitamin C supplement for regular use.. * Adrenal C Formula is an example of how Dr. Wilsons formulating expertise has allowed him to considerably improve on adrenal supplements that were available when ...
One very good method of good upbringing is the appreciation and encouragement when a child performs well. This will have a salutary effect on the mind of the child. It will provide him the reason to do still better in the future. Every human being loves himself. In his own way he thinks of developing and advancing his personality. He wants that others recognize and appreciate his personality. If he receives the appreciation of others, he will strive for further improvement. But if he is discouraged, his enthusiasm will be dampened. A few suggestions for obtaining good results are given here:. 1. The actions of the child can be appreciated, but not too often. Because , if the appreciation is too much, it might lose its importance in the eyes of the child. He may then take your appreciation as a matter of routine.. 2. The appreciation of the child should be at a specific place and time so that he realizes why and for what he is being commended. Then he will try to perform better and earn ...
Dehidroepiandrosteron (DHEA, Fidelin, androstenolon, prasteron, 3β-hidroksiandrost-5-en-17-on, 5-androsten-3β-ol-17-on) je važan endogeni steroidni hormon.[1] On je najzastupljeniji circulišući steroid kod ljudi,[2] kod kojih ga proizvode nadbubrežne žlezde,[3] gonade, i mozak,[4] gde on predominentno funkcioniše kao metabolički intermedijer u biosintezi androgena i estrogena seksualnih steroida.[1][5] Međutim, DHEA takođe ima raznovrsne samostalne potencijalne biološke efekte. On se vezuje za niz nuklearnih površinskih receptora,[6] i deluje kao neurosteroid.[7]. ...
Brain injury attorneys at Scarlett Law Group discuss new AED treatments used to speed remission among post-traumatic epilepsy patients.
Synthesis of 17b-hydroxy-androst-4-eno[3,2-c]pyrazole 3, 17b-hydroxy-androst-4-eno[3,2-c]-1 H-5 -methylthio-pyrazole 4, 17b-hydroxy-androst-4-eno[2,3-d]isoxazole 5, 17b-hydroxy-androst-4-eno[2,3-d] -1 H-3 -methylthio isoxazole 6, 17b-hydroxy-androst-4-eno[3,2-d]-2 -amino-6 -ethoxypyrimidine 7, 17b,2 -dihydroxy-androst-4-eno[3,2-d]- 6 -ethoxypyrimidine 8, and 17b-hydroxy-androst-4-eno[3,2-d]-2 -thiolo-6 -ethoxypyrimidine 9, 17b-hydroxy-4-androsteno[3,2-d]-2 -amino-6 -ethoxypyrimidine 10, 17b,2 -dihydroxy-4-androsteno[3,2-d]-6 ethoxypyrimidine 11, 17b-hydroxy-4-androsteno[3,2-d]-2 -thiolo-6 -ethoxypyrimidine 12, from 2-ethoxymethylene-4-androsten-3-one 1 and 2-bis (methylthio) methylene-4-androsten-3-one 2 are reported ...
A recent study shows some 1,150 deaths were tied to AED failures over a 15-year pe-riod, and nearly one in four of those failures were caused by problems with batteries. Dr. Deluca, the studys lead author, determined that 23.2 percent of the AED failures were due to battery/power failures, while 23.7 percent were due to problems with the pads or connectors.. Even though the report describes a variety of maintenance related problems, DeLuca is quick to note that AED failures appear to be very rare. "I dont want to send the mes-sage that these devices are unsafe or that they dont work," DeLuca said. "Most of the time they do work and they save lives.". AED batteries generally last up to five years. But it is important to implement an AED program that regularly checks for error mes-sages and could alert users about low batteries.. AED maintenance is key to having a successful AED program, step up and keep your AED program running smoothly. Visit ...
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Dehydroepiandrosterone 兔多克隆抗体(ab35062)经ELISA, RIA, Neut实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
... : Lyophilisierte toxikologische Serumkontrolle für die quantitative Bestimmung von Antiepileptika (Anticonsvulsants) in 2 Leveln.
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Find quality suppliers and manufacturers of 58-20-8(Androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17b)-) for price inquiry. where to buy 58-20-8(Androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17b)-).Also offer free database of 58-20-8(Androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17b)-) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
Synonyms for 4-dehydroepiandrosterone are: 3β-Hydroxy-4-androsten-17-one, 3β-hydroxyandrost-4-en-17-one, 3β-hydroxy-D4-androsten-17-one, 3β-hydroxyandrost-4-en-17-one, 3β-hydroxy-etioallocholan-4-en-17-one, and 4-androsten-3β-ol-17-one. ...
Epidemiological field studies that are planned to evaluate associations between serum hormone levels and risk of cancer may require that many samples be analyzed over a period of months or years. The degree of variability in hormone assay results should be small enough so that the assay is likely to detect differences between cases and controls. In this study, we have obtained data on components of variability in androgen assay results. Such data allow one to assess the reproducibility of these assays and the measurements for epidemiological studies.. ADIOL G, DHEA, DHEA S, DHT, TESTO, and ADION were assayed in several laboratories. There was variation in the mean assay levels among the participating labs, but the correlations of rankings of subjects mean results among the labs were high. The CVs were fairly high and did not vary widely by menstrual or menopausal states. The CVs for measurements from lab 1 were usually ,15% but ranged to 20%, whereas those from lab 2 were usually ,20% but ...
Question - Having high DHEA-S levels and prescribed with dehydroepiandrosterone capsules. Is this ok ?. Ask a Doctor about uses, dosages and side-effects of Dehydroepiandrosterone capsules, Ask an Infertility Specialist
Dehydroepiandrosterone (DHEA) is synthesized in the adrenals and the brain. Additionally, DHEA is produced at high concentrations in the human embryo enhancing neuronal development. Its production...
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Simulaids® TI Rescue Randy - 145 or 165 lbs Manikin-With the thermal imaging capability of the Simulaids® TI Rescue Randy expands your options for rescue training. Thermal imaging scanners now have the capability to see Randy at a distance of ove
CAS: 15262-86-9 MF: C25H38O3 MW: 386.57 EINECS: 239-307-1 Synonyms: 17beta-hydroxyandrost-4-ene-3-one 4-methylvalerate;4-ANDROSTEN-17-BETA-OL-3-ONE ISOCAPROATE;4-ANDROSTEN-17BETA-OL-3-ONE ISOCAPRONATE;4-ANDROSTEN-17BETA-OL-3-ONE...
Hi-Tech Pharmaceuticals brand new Androdiol® brings to market the most potent, patented, legal bodybuilding prohormone and testosterone booster available today. Androdiol® utilizes 4-androstene-3b-ol, 17-one, which has been shown to be very effective by itself. Hi-Tech then massively improves delivery via a specially p
DHEADehydroepiandrosterone (pronounced dee-hi-dro-epp-ee-ann-dro-stehr-own), or DHEA as it is more often called, is a steroid hormone produced in the adrenal gland. It is the most abundant steroid in the bloodstream and is present at even higher levels in brain tissue. Dehydroepiandrosterone levels are known to fall precipitously with age, falling 90% from age 20 to age 90. DHEA is known to be a precursor to
Testosterone (Steroids) Chemical name: 4-Androsten-17B-ol-3-one Synonyms:17beta-Hydroxyandrost-4-en-3-one CAS: 58-22-0 EINECS: 200-370-5 Assay: 98% min. Molecular formula: C19H28O2 Moleculare structure: Packing: foil bag or tin. Appearance: white...
Dehydroepiandrosterone (DHEA) is a steroid produced in the adrenal glands. It is converted in the body to testosterone and estrogen and acts similarly to ...
The IUPHAR/BPS Guide to Pharmacology. dehydroepiandrosterone ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
One of the life-altering medical conditions youre most likely to experience at some point in your life is cardiac arrest. No matter if youre living with an ill family member or if youre setting up a commercial office where an AED is required based on regulations, youre going to need to find the best AED pads of 2018 for your kit.. Theres nothing more important than ensuring that you keep all your life-saving equipment up to date, especially for personal and professional resuscitation devices. In this guide, we explore five of the top AED pads on the market for both training and real-world applications to make sure youre prepared for absolutely anything that comes your way. ...
7 Keto DHEA has been thrown in the limelight recently a safe, healthy means to lose weight. 7 Keto DHEA is a natural derivative of dehydroepiandrosterone, or DHEA. ...
The remarkable underwater adhesion strategy employed by mussels has inspired bioadhesives that have demonstrated promise in connective tissue repair, wound closure, and local delivery of therapeutic cells and drugs. While the pH of oxygenated blood and internal tissues is typically around 7.4, skin and tumor tissues are significantly more acidic. Additionally, blood loss during surgery and ischemia can lead to dysoxia, which lowers pH levels of internal tissues and organs. Using 4-armed PEG end-capped with dopamine (PEG-D) as a model adhesive polymer, the effect of pH on the rate of intermolecular cross-linking and adhesion to biological substrates of catechol-containing adhesives was determined. Adhesive formulated at an acidic pH (pH 5.7-6.7) demonstrated reduced curing rate, mechanical properties and adhesive performance to pericardium tissues. Although a faster curing rate was observed at pH 8, these adhesives also demonstrated reduced mechanical and bioadhesive properties when compared to ...
5α-Androst-1-ene-3,17-dione (1-AD) is listed on the World Anti-Doping Agencys prohibited list as an "exogenous anabolic androgenic steroid". It could be marketed in dietary supplements. An excretion study was conducted with six male volunteers, to whom were orally administered 50 mg of 1-AD in one-time application. Urine samples were collected for two weeks. The metabolites were measured as TMS-derivatives with GC/MS. The intake was detectable up to eight days based on the main metabolite 3α-hydroxy-5α-androst-1-en-17-one (1-DHA). 1-DHA was synthesized from 5α-androst-2-en-17-one via the 2,3-epoxid as an intermediate and structurally identified with GC/MS and NMR. Other identified metabolites were 17β-hydroxy-5α-androst-1-en-3-one (1-testosterone), 5α-androst-1-ene-3α,17β-diol and 5α-androst-1-ene-3β,17β-diol. Furthermore two additional metabolites, presumably 18-hydroxy-5α-androst-1-ene-3,17-dione and 19-hydroxy-5α-androst-1-ene-3,17-dione, but until now without final ...
250 µCi quantities of Androst-4-ene-3, [1,2,6,7-3H(N)]-, 17-Dione are available for your research. Application of [3H] Androstenedione can be found in: effects of HCG and PMS on bioconversion in steroid biochemistry, breast cancer cell research, inhibition study of human placental aromatase in steroid biochemistry, in vitro metabolism studies in steroid chemistry; etc. ...
Looking for dehydroepiandrosterone? Find out information about dehydroepiandrosterone. C19H28O2 Dimorphous crystals with a melting point of 140-141°C, or leaflet crystals with a melting point of 152-153°C; soluble in alcohol, benzene, and... Explanation of dehydroepiandrosterone
Delta-isomerase 2 (HSD3B2) which catalyzes the conversion of Dehydroepiandrosterone (DHEA) to androstenedione, a critical step in producing DHT from adrenal androgens, is also overexpressed at high levels [201]. Taken together, these data suggest a mechanism for how MCRPCa cells can continue to upregulate genes that require AR transactivation. The most obvious argument against this model is that t
The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) > testosterone > androstenediol > ...
Marketed Androstenediol (A5; 5-androstenediol) Boldenone (δ1-T)* Dehydroepiandrosterone (DHEA; prasterone, 5-androstenolone) ... 19-Nor-5-androstenediol (19-NA5)* Adrenosterone (11-ketoandrostenedione; 11-KA4) Androstenedione (A4; 4-androstenedione) ...
Androstenediol Androstenedione Androstenolone. ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (A5) is the steroid metabolite thought to act as the main regulator of gonadotropin secretion.[citation needed] ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Testosterone derivatives: Androstenediol dipropionate. *Boldenone undecylenate. *Clostebol. *Clostebol acetate. *Clostebol ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Testosterone derivatives: Androstenediol dipropionate. *Boldenone undecylenate. *Clostebol. *Clostebol acetate. *Clostebol ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenediol Product name:Androstenediol. Androstenediol. M1,4ADD is a prohormone that is proclamied to convert to the ... Androstenediol Androstenediol - Mfrbee * Relate products of Androstenediol Androstenediol. Androstenediol Product name: ... Androstenediol Androstenediol Product name:Androstenediol Androstenediol Appearance: white powder. Androstenediol Packing: as ... Androstenediol C19H30O2 - PubChe * Andro and Androstenediol -Ester * Androstenediol, or 5-androstenediol (abbreviated as A5 or ...
Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous ... This article is about androstenediol the hormone. For other uses, see Androstenediol (disambiguation). ... Androstenediol, also known as androst-5-ene-3β,17β-diol, is a naturally occurring androstane steroid.[5] It is closely related ... Androstenediol is a direct metabolite of the most abundant steroid produced by the human adrenal cortex, DHEA. It is less ...
Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous ... Androstenediol, also known as androst-5-ene-3β,17β-diol, is a naturally occurring androstane steroid. It is closely related ... Although androstenediol has far lower affinity for the ERs compared to the major estrogen estradiol, it circulates at ... Androstenediol possesses potent estrogenic activity, similarly to DHEA and 3β-androstanediol. It has approximately 6% and 17% ...
1-Androstenediol, or 5α-androst-1-ene-3β,17β-diol, also known as 4,5α-dihydro-δ1-4-androstenediol, is a prohormone of 1- ...
Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), ... 5-Androstenediol. PDB Entries. 3klp. Clinical Trials. Clinical Trials Not Available. Pharmacoeconomics. Manufacturers. Not ... Androstenediol. Accession Number. DB01524. Type. Small Molecule. Groups. Experimental, Illicit. Description. An intermediate in ... Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), ...
19-Nor-5-androstenediol, also known as estr-5-ene-3β,17β-diol, is a synthetic, orally active anabolic-androgenic steroid (AAS) ... 19-Nor-5-androstenediol, 19-nor-5-androstenedione, and other 19-norandrostane prohormones were considered to be nutritional ... glucuronide and sulphate conjugates after oral administration of 19-nor-4-androstenediol". Rapid Commun. Mass Spectrom. 22 (19 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=19-Nor-5-androstenediol&oldid=901955481" ...
4-Androstenediol. Description. 4-Androstenediol is a metabolite of testosterone. Conversely, the conversion of 4-androstenediol ... Showing metabocard for 4-Androstenediol (HMDB0005849). Jump To Section: IdentificationTaxonomyOntologyPhysical properties ... 4-Androstenediol is an anabolic agent that has been found in increased concentration in athletes suspected of doping. 4- ... It has been demonstrated that 4-androstenediol taken by mouth is capable of producing in vivo increases in testosterone ...
Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), ...
The role of androst-5-ene-3 beta,17 beta-diol (androstenediol) in cell proliferation in endometrium of women with polycystic ... The role of androst-5-ene-3 beta,17 beta-diol (androstenediol) in cell proliferation in endometrium of women with polycystic ...
4-androstenediol, 5-androstenediol, (Adiol), alpha-androstenediol, "Andro" prohormones, androstenediol 3-sulfate (ADIOLS), ... Androstenediol may interact with anticancer agents. Androstenediol may stimulate the growth of breast cancer cells and exert ... Androstenediol may interact with anticancer agents. Androstenediol may stimulate the growth of breast cancer cells and exert ... Serum concentrations of androstenediol and androstenediol sulfate, and their relation to cytokine production during and after ...
Androstenediol. Another hormone (like androstenedione and DHEA) that your body creates as a precursor to testosterone and that ...
Androstenediol/Lab Interactions:*Hormone levelsHormone levels: Based on clinical studies, androstenediol may increase estradiol ... Androstenediol/Herb/Supplement Interactions:*AntibacterialsAntibacterials: The immune boosting effects of androstenediol in ... this therapy may decrease plasma androstenediol and androstenediol free index levels, despite a lack of effects on the ... Androstenediol/Drug Interactions:*Aminoglutethimide-plus-hydrocortisone therapyAminoglutethimide-plus-hydrocortisone therapy: ...
5Androstenediol abbreviated as 5diol commonly referred to simply as androstenediol and also known as androst5ene317diol and ... Δ5-Androstenediol (abbreviated as Δ5-diol), commonly referred to simply as androstenediol, and also known as androst-5-ene-3β, ... It is less androgenic than the related compound, Δ4-androstenediol, and has been found to stimulate the immune system. When ...
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Androstenediol (5-androstenediol) *Androstenediol 3β-acetate. *Androstenediol 17β-acetate. *Androstenediol diacetate ...
Androstenedione and Androstenediol:a safe way to restore declining testosterone. To combat problems associated with low ... In summary: The new, androstenediol spray is an extremely safe and effective way for both men and women to raise their ...
Androstenediol complements estrogenic bioactivity during the menopausal transition. Lasley, Bill L.; Chen, Jiangang; Stanczyk, ... Androstenediol contributes to circulating estrogenicity when estradiol production falls at menopause and may contribute ...
iii) androstenediol- (I) 1-androstenediol (3β,17β-dihydroxy-5α-androst-1-ene); ... 1-androstenediol (3α,17β-dihydroxy-5α-androst-1-ene); ... 19-nor-5-androstenediol (3β, 17β-dihydroxyestr-5-ene); and ...
I) 1-androstenediol (3b,17b-dihydroxy-5a-androst-1-ene);. (II) 1-androstenediol (3a,17b-dihydroxy-5a-androst-1-ene); ...
11-dehydrocorticosterone and Δ5-androstenediol. Deuterated progesterone (4-pregnen-3,20-dione-2,2,4,6,6,17α,21,21,21-d9; ...
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Fingerprint Dive into the research topics of Age-dependent increases in adrenal cytochrome b5 and serum 5-androstenediol-3- ... Age-dependent increases in adrenal cytochrome b5 and serum 5-androstenediol-3-sulfate. Journal of Clinical Endocrinology and ... Age-dependent increases in adrenal cytochrome b5 and serum 5-androstenediol-3-sulfate. / Rege, Juilee; Karashima, Shigehiro; ... title = "Age-dependent increases in adrenal cytochrome b5 and serum 5-androstenediol-3-sulfate", ...
1-Androstenediol. *1-Butyl-3-(1-Naphthoyl)Indole. *1-Dimethylamino-1,2-Diphenylethane ...
1-Androstenediol. 1-AD. 1-Androstenedione. 5?-androst-2-ene-17-one. ...
Androstenediol Angelica (cream applied 1 hour "prior" prevents premature ejaculation) Inosine Schisandra Siberian ginseng ... Androstenediol-increases testosterone Coffee-heavy consumption decreases number of motile sperm. Gossypol-spermicide Saw ...
  • Androstenediol is a direct metabolite of the most abundant steroid produced by the human adrenal cortex , DHEA. (wikipedia.org)
  • Androstenediol possesses potent estrogenic activity, similarly to DHEA and 3β-androstanediol . (wikipedia.org)
  • Megestrol acetate - Wikipedia, the free encyclopedia (http://en.wikipedia.org/wiki/Megace) Chemical Name(s): Androst 3,5-dien-7,17-dione 3-deoxy-7-oxo-DHEA. (antehealth.com)
  • Objective: This study sought to simultaneously measure serum levels of four adrenal Δ5-steroid sulfates, pregnenolone sulfate (Preg-S), 17α-hydroxypregnenolone sulfate (17OHPreg-S), DHEA-S, and 5-androstenediol-3-sulfate (Adiol-S) as a function of age and relate their production to the age-dependent adrenal localization of CYB5A. (elsevier.com)
  • Endocrine regulation of the immune response to influenza virus infection with a metabolite of DHEA-androstenediol. (ajtmh.org)
  • The 3-hydroxysteroids, androsterone, epiandrosterone and androstenediol, were conjugated at 50-60% of the rate of DHEA. (nih.gov)
  • 4-Androstenediol has also been found in aqueous and solid nutritional supplements that are commercially available. (hmdb.ca)
  • Although androstenediol has far lower affinity for the ERs compared to the major estrogen estradiol , it circulates at approximately 100-fold higher concentrations, and so is thought may play a significant role as an estrogen in the body. (wikipedia.org)
  • 17beta-HSD14 is a SDR enzyme able to oxidize estradiol and 5-androstenediol using NAD+. (proteopedia.org)
  • 19-Nor-5-androstenediol , also known as estr-5-ene-3β,17β-diol , is a synthetic , orally active anabolic-androgenic steroid (AAS) and a derivative of 19-nortestosterone (nandrolone) that was never introduced for medical use . (wikipedia.org)
  • Antibiotics Antibiotics: The immune boosting effects of androstenediol in humans and animals may protect against bacterial infections by Enterococcus faecalis, Pseudomonas aeruginosa, and Klebsiella pneumonia ( 14 ). (themainstreetmarket.com)
  • The present invention provides an improved means for regulating the immune response, for ameliorating effects of stress, and for avoiding untoward effects of chemotherapy or exposure to irradiation by administration of androstenediol (AED) and androstenetriol (AET). (google.com)
  • 4-Androstenediol is an anabolic agent that has been found in increased concentration in athletes suspected of doping. (hmdb.ca)