Androstenediol: An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).Androstenediols: Unsaturated androstane derivatives which are substituted with two hydroxy groups in any position in the ring system.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.Portal Pressure: The venous pressure measured in the PORTAL VEIN.Portal System: A system of vessels in which blood, after passing through one capillary bed, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system.Shock, Hemorrhagic: Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicity. (1/60)

The protective effects of the hormones androstenediol (androstene-3beta, 17beta,-diol; AED) and dehydroepiandrosterone (5-androsten-3beta-ol-17-one; DHEA) on the pathophysiology of two lethal bacterial infections and endotoxin shock were examined. The infections included a gram-positive organism (Enterococcus faecalis) and a gram-negative organism (Pseudomonas aeruginosa). Both hormones protected mice from the lethal bacterial infections and from lipopolysaccharide (LPS) challenge. Treatment of animals lethally infected with P. aeruginosa with DHEA resulted in a 43% protection whereas treatment with AED gave a 67% protection. Both hormones also protected completely animals infected with an LD50 dose of E. faecalis. Similarly, the 88% mortality rate seen in LPS challenge was reduced to 17% and 8.5%, by treatment with DHEA and AED, respectively. The protective influences of both steroids were shown not to be directly antibacterial, but primarily an indirect antitoxin reaction. DHEA appears to mediate its protective effect by a mechanism that blocks the toxin-induced production of pathophysiological levels of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1. AED usually had greater protective effects than DHEA; however, the AED effect was independent of TNF-alpha suppression, both in vivo and in vitro. The data suggest that both DHEA and AED may have a role in the neuro-endocrine regulation of antibacterial immune resistance.  (+info)

Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells. (2/60)

Our earlier report suggested that androst-5-ene-3beta,7beta-diol (Delta(5)-androstenediol or Adiol) is a natural hormone with androgenic activity and that two potent antiandrogens, hydroxyflutamide (Eulexin) and bicalutamide (Casodex), fail to block completely the Adiol-induced androgen receptor (AR) transactivation in prostate cancer cells. Here, we report the development of a reporter assay to screen several selective steroids with anti-Adiol activity. Among 22 derivatives/metabolites of dehydroepiandrosterone, we found 4 steroids [no. 4, 1,3,5(10)-estratriene-17alpha-ethynyl-3, 17beta-diol; no. 6, 17alpha-ethynyl-androstene-diol; no. 8, 3beta, 17beta-dihydroxy-androst-5-ene-16-one; and no. 10, 3beta-methylcarbonate-androst-5-ene-7,17-dione] that have no androgenic activity and could also block the Adiol-induced AR transactivation in prostate cancer PC-3 cells. Interestingly, these compounds, in combination with hydroxyflutamide, further suppressed the Adiol-induced AR transactivation. Reporter assays further showed that these four anti-Adiol steroids have relatively lower glucocorticoid, progesterone, and estrogenic activity. Together, these data suggest some selective steroids might have anti-Adiol activity, which may have potential clinical application in the battle against the androgen-dependent prostate cancer growth.  (+info)

Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha. (3/60)

Estrogens stimulate the proliferation of many breast tumors and cell lines derived from them. Antiestrogens have therefore become a powerful therapeutic agent to treat breast tumors that express estrogen receptor (ER) alpha. In addition, aromatase inhibitors are now used in postmenopausal women to block the in situ conversion of adrenal androgens to estrogens. This approach can only be successful if ER-alpha in a particular tumor is not directly stimulated by adrenal androgens. We have examined this possibility using several different cell lines as model systems: (a) wild-type MCF7 cells, an ER-alpha-dependent human breast cancer cell line; (b) MCF7SH cells, an estrogen-independent MCF7 variant; (c) Ishikawa cells, an ER-alpha-containing human uterine cell line; (d) ER-negative HeLa cells; and (e) budding yeast. Transactivation assays with transfected ER-alpha reporter genes reveal a direct activation of ER-alpha by dehydroepiandrosterone (DHEA), 5alpha-androstene-3beta,17beta-diol, testosterone, and the two nonaromatizable androgens, dihydrotestosterone and 5alpha-androstane-3beta,17beta-diol. The involvement of other steroid receptors could be ruled out with specific antihormones. Moreover, the same set of ligands stimulates the proliferation of the two breast cancer cell lines. At subsaturating and physiologically relevant concentrations of DHEA, DHEA stimulates the proliferation of MCF7SH cells, which correlates with a substantial, albeit submaximal, transcriptional response. Thus, adrenal androgens must also be considered as risk factors in postmenopausal women.  (+info)

Over-the-counter delta5 anabolic steroids 5-androsen-3,17-dione; 5-androsten-3beta, 17beta-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3,17-dione: excretion studies in men. (4/60)

Studies of urinary steroids were performed in males after oral administration of 5-androsten-3,17-dione; 5-androsten-3beta,17beta-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3,17-dione. 5-Androsten-3,17-dione; 5-androsten-3beta,17beta-diol; and dehydroepiandrosterone amplify most endogenous steroids, but to a lesser extent than their delta4 analogues do. Especially affected are androsterone, etiocholanolone, dehydroandrosterone, dehydroepiandrosterone, and isomeric 5-androstendiols. 5-Androsten-3,17-dione; 5-androsten-3beta,17beta-diol; and dehydroepiandrosterone elevate the urinary testosterone to epitestosterone (T/E) ratio by a factor of 2-3 a few hours after administration. This may cause a positive T/E test (> 6) for individuals with normal T/E ratios higher than 2. Most of the steroids return to their original concentrations in less than 24 h. Etiocholanolone and 5beta-androstan-3alpha,17beta-diol remain elevated for several days. A reduced androsterone to etiocholanolone (A/E) ratio may be an indication of delta5 steroids abuse. 19-Nor-5-androsten-3,17-dione has a similar effect, except that all metabolites in urine are 19-nor exogenous steroids. Identification criteria for 19-nor-5-androsten-3,17-dione may be the same as nandrolone, that is, detection of 19-norandrosterone and 19-noretiocholanolone. Specific abundant metabolites of 19-nor-5-androsten-3,17-dione are 19-nordehydroandrosterone and 19-nordehydroepiandrosterone. In the later stages of excretion, higher concentration of 1 9-noreticholanolone relative to 19-norandrosterone specifically indicates administration of 19-nor delta5 steroids.  (+info)

Interactions between hormone-mediated and vaccine-mediated immunotherapy for pulmonary tuberculosis in BALB/c mice. (5/60)

Problems of logistics, compliance and drug resistance point to an urgent need for immunotherapeutic strategies capable of shortening the current 6-month chemotherapy regimens used to treat tuberculosis, or of supplementing ineffective therapy. In this study we sought to define the mechanism of action of two immunotherapies, both of which have previously been shown to prolong survival. Secondly, we wished to identify any clinically useful synergy between these therapies. In BALB/c mice infected via the trachea with Mycobacterium tuberculosis H37Rv there is an initial phase of partial resistance dominated by type 1 cytokines plus tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1), followed by a phase of progressive disease. This progressive phase is accompanied by increasing expression of IL-4, and diminished expression of IL-1 and TNF-alpha. Animals in this late progressive phase of the disease (day 60) were treated with two injections (day 60 and day 90) of 0.1 or 1.0 mg of heat-killed Mycobacterium vaccae, or with 3beta, 17beta-androstenediol (AED; 25 microg subcutaneously three times/week), or with both therapies. We show here using four techniques in parallel (morphometry, immunohistochemistry with automated cell counting, semiquantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assays of cytokines in lung extracts) that treatment with M. vaccae causes a switch back towards a type 1 cytokine profile, restoration of expression of IL-1alpha and TNF-alpha, and a switch from pneumonia to granuloma. This is very similar to the changes previously seen after treatment with AED. However, there was no evidence for synergy between M. vaccae and AED.  (+info)

Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism. (6/60)

Androstenediol (5-androsten-3beta, 17beta-diol, ADIOL) and androstenediol 3-sulfate (ADIOLS) are active metabolites of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS), respectively, and have estrogenic activity and immunoregulatory function. We examined serum concentrations of ADIOL, ADIOLS, DHEA, DHEAS and pregnenolone sulfate (5-pregnen-3beta-ol-20-one sulfate, PREGS) in patients with Graves' thyrotoxicosis (male/female 9/14), hypothyroidism (11/20) and in normal controls (14/29). In hypothyroidism serum levels of all these steroids were significantly decreased in both genders. In hyperthyroidism, in contrast, serum levels of ADIOLS (male 1.49 +/- 0.69, female 0.64 +/- 0.31 micromol/l), DHEAS (male 7.43 +/- 3.91, female 5.13 +/- 2.03 micromol/l), and PREGS (male 1.13 +/- 0.58, female 1.07 +/- 0.85 micromol/l) were markedly increased, but serum concentrations of ADIOL and DEHA were not significantly different from controls (ADIOLS male 0.36 +/- 0.33, female 0.14 +/- 0.09 micromol/l; DHEAS male 2.88 +/- 1.70, female 1.86 +/- l1.03pmol/l; PREGS male 0.18 +/- 0.12, female 0.11 +/- 0.08 micromol/l; ADIOL male 3.76 +/- 1.35, female 1.91 +/- 1.17 nmol/l; DHEA male 9.23 +/- 3.49, female 13.5 +/- 10.8nmol/l). Serum concentrations of all these steroids correlated with the serum concentration of the thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentrations of steroids. These findings indicate that serum concentrations of ADIOLS, ADIOL, DHEAS, DHEA and PREGS were decreased in hypothyroidism, whereas serum ADIOLS, DHEAS and PREGS concentrations were increased but ADIOL and DHEA were normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids and sulfotransferase is speculated to be increased in hyperthyroidism. Increased ADIOLS might contribute to menstrual disturbances and gynecomastia in hyperthyroidism.  (+info)

Acute hormonal response to sublingual androstenediol intake in young men. (7/60)

The effectiveness of orally ingested androstenediol in raising serum testosterone concentrations may be limited because of hepatic breakdown of the ingested androgens. Because androstenediol administered sublingually with cyclodextrin bypasses first-pass hepatic catabolism, we evaluated the acute hormonal response to sublingual cyclodextrin androstenediol supplement in young men. Eight men (22.9 +/- 1.2 yr) experienced in strength training consumed either 20 mg androstenediol in a sublingual cyclodextrin tablet (Sl Diol) or placebo (Pl) separated by at least 1 wk in a randomized, double-blind, crossover manner. Blood samples were collected before supplementation and at 30-min intervals for 3 h after supplementation. Serum hormone concentrations did not change with Pl. Serum androstenedione concentrations were increased (P < 0.05) above baseline (11.2 +/- 1.1 nmol/l) with Sl Diol from 60 to 180 min after intake and reached a peak concentration of 25.2 +/- 2.9 nmol/l at 120 min. Serum free testosterone concentrations were increased from 86.2 +/- 9.1 pmol/l with Sl Diol from 30 to 180 min and reached a peak concentration of 175.4 +/- 12.2 pmol/l at 60 min. Serum total testosterone concentrations increased above basal (25.6 +/- 2.3 nmol/l) from 30 to 180 min with Sl Diol and reached a peak concentration of 47.9 + 2.9 nmol/l at 60 min. Serum estradiol concentrations were elevated (P < 0.05) above baseline (0.08 +/- 0.01 nmol/l) from 30 to 180 min with Sl Diol and reached 0.14 +/- 0.02 nmol/l at 180 min. These data indicate that sublingual cyclodextrin androstenediol intake increases serum androstenedione, free testosterone, total testosterone, and estradiol concentrations.  (+info)

Phenotypic adaptations in human muscle fibers 6 and 24 wk after spinal cord injury. (8/60)

The effects of spinal cord injury (SCI) on the profile of sarco(endo) plasmic reticulum calcium-ATPase (SERCA) and myosin heavy chain (MHC) isoforms in individual vastus lateralis (VL) muscle fibers were determined. Biopsies from the VL were obtained from SCI subjects 6 and 24 wk postinjury (n = 6). Biopsies from nondisabled (ND) subjects were obtained at two time points 18 wk apart (n = 4). In ND subjects, the proportions of VL fibers containing MHC I, MHC IIa, and MHC IIx were 46 +/- 3, 53 +/- 3, and 1 +/- 1%, respectively. Most MHC I fibers contained SERCA2. Most MHC IIa fibers contained SERCA1. All MHC IIx fibers contained SERCA1 exclusively. SCI resulted in significant increases in fibers with MHC IIx (14 +/- 4% at 6 wk and 16 +/- 2% at 24 wk). In addition, SCI resulted in high proportions of MHC I and MHC IIa fibers with both SERCA isoforms (29% at 6 wk and 54% at 24 wk for MHC I fibers and 16% at 6 wk and 38% at 24 wk for MHC IIa fibers). Thus high proportions of VL fibers were mismatched for SERCA and MHC isoforms after SCI (19 +/- 3% at 6 wk and 36 +/- 9% at 24 wk) compared with only ~5% in ND subjects. These data suggest that, in the early time period following SCI, fast fiber isoforms of both SERCA and MHC are elevated disproportionately, resulting in fibers that are mismatched for SERCA and MHC isoforms. Thus the adaptations in SERCA and MHC isoforms appear to occur independently.  (+info)

*Androstenedione

However, in contrast to androstenediol, its affinity for the estrogen receptors is very low, with less than 0.01% of the ... It is closely related to androstenediol (androst-5-ene-3β,17β-diol). Androstenedione is a precursor of testosterone and other ... Under the brand name Metharmon-F and in combination of sex steroids (pregnenolone, testosterone, estrone, androstenediol) and ... It is closely related structurally to androstenediol (A5; androst-5-ene-3β,17β-diol), dehydroepiandrosterone (DHEA; androst-5- ...

*Androstenediol

... , or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous ... Androstenediol, also known as androst-5-ene-3β,17β-diol, is a naturally occurring androstane steroid. It is closely related ... Although androstenediol has far lower affinity for the ERs compared to the major estrogen estradiol, it circulates at ... Androstenediol possesses potent estrogenic activity, similarly to DHEA and 3β-androstanediol. It has approximately 6% and 17% ...

*4-Androstenediol

... , also known as androst-4-ene-3β,17β-diol, is an androstenediol that is converted to testosterone. The ... 4-Androstenediol is closer to testosterone structurally than 5-androstenediol, and has androgenic effects, acting as a weak ... 4-androstenediol has antagonistic actions, behaving more like an antiandrogen. 4-Androstenediol is very weakly estrogenic. It ... Patrick Arnold holds a 1999 patent on "Use of 4-androstenediol to increase testosterone levels in humans". Chen F, Knecht K, ...

*Androstenediol sulfate

... , also known as androst-5-ene-3β,17β-diol 3β-sulfate, is an endogenous, naturally occurring steroid and a ... urinary metabolites of androstenediol.> It is a steroid sulfate which is formed from sulfation of androstenediol by steroid ... sulfotransferase and can be desulfated back into androstenediol by steroid sulfatase. Steroid sulfate Mueller JW, Gilligan LC, ...

*1-Androstenediol

... , or 5α-androst-1-ene-3β,17β-diol, also known as 4,5α-dihydro-δ1-4-androstenediol, is a prohormone of 1- ...

*Androstenediol diacetate

... , or 5-androstenediol 3β,17β-diacetate, also known as androst-5-ene-3β,17β-diol 3β,17β-diacetate, is a ... synthetic anabolic-androgenic steroid and an androgen ester - specifically, the C3β,17β diacetate diester of 5-androstenediol ( ...

*Androstenediol (disambiguation)

Androstenediol may refer to: 5-Androstenediol (androst-5-ene-3β,17β-diol) - an endogenous weak androgen and estrogen and ... a weak androgen and prohormone of testosterone and hence an anabolic-androgenic steroid 1-Androstenediol (5α-androst-1-ene-3β, ... intermediate to/prohormone of testosterone 4-Androstenediol (androst-4-ene-3β,17β-diol) - ...

*Androstenediol dipropionate

... (brand names Bisexovis, Bisexovister, Ginandrin, Stenandiol), or 5-androstenediol 3β,17β- ... the dipropionate diester of 5-androstenediol (androst-5-ene-3β,17β-diol) - which has been marketed in Europe, including in ...

*19-Nor-5-androstenediol

5-Androstenediol Bolandiol (19-nor-4-androstenediol) Bolandione (19-nor-4-androstenedione) Bolenol (17α-ethyl-19-nor-5- ... 19-Nor-5-androstenediol, also known as estr-5-ene-3β,17β-diol, is a synthetic, orally active anabolic-androgenic steroid (AAS) ... 19-Nor-5-androstenediol, 19-nor-5-androstenedione, and other 19-norandrostane prohormones were considered to be nutritional ... glucuronide and sulphate conjugates after oral administration of 19-nor-4-androstenediol". Rapid Commun. Mass Spectrom. 22 (19 ...

*Sex hormone-binding globulin

The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) > testosterone > androstenediol > ...

*List of androgens/anabolic steroids (alternate)

Marketed Androstenediol (A5; 5-androstenediol) Boldenone (δ1-T)* Dehydroepiandrosterone (DHEA; prasterone, 5-androstenolone) ... 19-Nor-5-androstenediol (19-NA5)* Adrenosterone (11-ketoandrostenedione; 11-KA4) Androstenedione (A4; 4-androstenedione) ...

*Dehydroepiandrosterone (disambiguation)

Androstenediol Androstenedione Androstenolone. ...

*1-Androstenedione

1-Androstenediol Zhang H, Qiu Z (December 2006). "An efficient synthesis of 5α-androst-1-ene-3,17-dione". Steroids. 71 (13-14 ...

*Androstanedione

Androstenedione Androstanediol Androstenediol Androstanolone Androstenolone "Metabocard for Androstanedione". Human Metabolome ...

*17β-Hydroxysteroid dehydrogenase

However, also catalyzes the conversion of DHEA into androstenediol. Recently, has been found to inactivate DHT into 3α- and 3β- ... This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol. The ... and androstenediol to DHEA). Also converts inactive 20α-hydroxyprogesterone into active progesterone. Preferential activity on ... androstenedione to testosterone and DHEA to androstenediol). Also activates estrogens from weaker forms to a lesser extent ( ...

*Chloromethylandrostenediol

1-Androstenediol Bolenol Methandriol Methylclostebol William Llewellyn (1 November 2008). Anabolics: Anabolic Steroid Reference ... and a 17α-alkylated derivative of 4-androstenediol that was never marketed. It was first encountered in 2005 when it was ...

*Prasterone enanthate

Androstenediol dipropionate Dehydroepiandrosterone sulfate Prasterone sulfate Düsterberg B, Wendt H (1983). "Plasma levels of ...

*Obesity and fertility

Androstenediol is important in fertility as it is the precursor to oestrogen. Without oestrogen production, the balance of ...

*Joel Brind

Brind, J. L. (1991). "Direct radioimmunoassay of androstenediol-3-sulfate in the serum of normal men". Steroids. 56 (6): 320- ...

*Patrick Arnold

In 2001 Arnold's company introduced the prohormone 1-Androstenediol, under the marketing name 1-AD. Like andro, 1-AD is a ... Patrick Arnold is an American organic chemist known for introducing androstenedione, 1-androstenediol, and methylhexanamine ...

*Androgen

Androstenediol (A5) is the steroid metabolite thought to act as the main regulator of gonadotropin secretion.[citation needed] ... and androstenediol (A5). Besides testosterone, other androgens include: Dehydroepiandrosterone (DHEA) is a steroid hormone ...

*Tribulus terrestris

"Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men". J Am Coll Nutr. 20 (5 ...

*Ethynylandrostanediol

Trauger R, Corey E, Bell D, White S, Garsd A, Stickney D, Reading C, Frincke J (2009). "Inhibition of androstenediol-dependent ...

*C23H34O4

The molecular formula C23H34O4 may refer to: Androstenediol diacetate Calcitroic acid Digitoxigenin Prebediolone acetate ...

*Congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency

3β-HSD II also mediates an alternate route of testosterone synthesis from androstenediol in the testes. 3β-HSD deficiency ...
... Anabolick l tky I. 1. Anabolick androg nne steroidy xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx a) Exog nne anabolick androg nne steroidy 1-androstenediol 1-androstendi nu Bolandiol Bolasterone Boldenone Boldion Calusteron Clostebol Danazol Chlorodehydromethyltestosterone Desoxymethyltestosterone Drostanolone Ethylestrenol Fluoxymesteron Formebolone Furazabol Gestrinone 4-hydroxytestosteron Mestanolone Mesterolone Methandrostenolone Methenolone Methandriol Methasteron Methyldienolon Metyl-1-testoster n Methylnortestosteron Methyltestosterone Metribolon, synonymick methyltrienolone Mibolerone Nandrolon 19-norandrostenedione Norboleton Norclostebol Norethandrolone Oxabolon Oxandrolone Oxymesterone Oxymetholone Prostanozol Quinbolone Stanozolol Stenbolone 1-testoster n Tetrahydrogestrinone Trenbolon Ostatn sofware s visiace s anabolick mi androg nne
An intermediate in testosterone biosynthesis, found in the testis or the adrenal glands. Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), is converted to testosterone by...
b. Endogenous** AAS when administered exogenously: androstenediol (androst-5-ene-3 ,17 -diol); androstenedione (androst-4-ene-3,17-dione); dihydrotestosterone (17 -hydroxy-5 -androstan-3-one) ; prasterone (dehydroepiandrosterone, DHEA); testosterone and the following metabolites and isomers: 5 -androstane-3 ,17 -diol; 5 -androstane-3 ,17 -diol; 5 -androstane-3 ,17 -diol; 5 -androstane-3 ,17 -diol; androst-4-ene-3 ,17 -diol; androst-4-ene-3 ,17 -diol; androst-4-ene-3 ,17 -diol; androst-5-ene-3 ,17 -diol; androst-5-ene-3 ,17 -diol; androst-5-ene-3 ,17 -diol; 4-androstenediol (androst-4-ene-3 ,17 -diol); 5-androstenedione (androst-5-ene-3,17-dione); epi-dihydrotestosterone; epitestosterone; 3 -hydroxy-5 -androstan-17-one; 3 -hydroxy-5 -androstan-17-one; 19-norandrosterone; 19-noretiocholanolone. [Comment to class S1.1b: Where an anabolic androgenic steroid is capable of being produced endogenously, a Sample will be deemed to contain such Prohibited Substance and an Adverse Analytical Finding will ...
Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA) and of estrone. It is closely related to androstenediol (androst-5-ene-3β,17β-diol). Androstenedione is a precursor of testosterone and other androgens, as well as of estrogens like estrone, in the body. In addition to functioning as an endogenous prohormone, androstenedione also has weak androgenic activity in its own right. Androstenedione has been found to possess some estrogenic activity, similarly to other DHEA metabolites. However, in contrast to androstenediol, its affinity for the estrogen receptors is very low, with less than 0.01% of the affinity of estradiol for both the ERα and ERβ. In children aged 6 to 8 years old, there is a rise in androstenedione secretion along with DHEA during adrenarche. This rise in androstenedione and DHEA is ...
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Androstenedione and its close cousins androstenediol, norandrostenedione, and others, are natural steroid hormones found in the body and available over the counter. There are several other steroid hormones available without a prescription, including DHEA and pregnenolone. Basically, pregnenolone is the grandmother of all the steroid hormones. Pregnenolone is able to convert into DHEA, which in turn converts into Andro (short for androstenedione).
The present invention provides an improved means for regulating the immune response, for ameliorating effects of stress, and for avoiding untoward effects of chemotherapy or exposure to irradiation by administration of androstenediol (AED) and androstenetriol (AET). The improved means of regulating immune response can be utilized in treating infectious diseases and immune diseases such as diabetes and chronic fatigue syndrome, both diseases now considered to be immune response related syndromes.
One of 30 tumors showed complete response (CR), 15 showed partial response (PR) and 14 showed stable disease (SD). All treatments were well tolerated. After treatment, a decrease of progesterone receptor expression was more frequent in responding tumors (93.8%) than in non-responding tumors (35.7%). Suppression of Ki67 after treatment was significantly greater in responding tumors than in non-responding tumors (P = 0.002). The mean BC tissue levels of E1, E2, E1S, ADIOL, and AONE at base line were 0.534, 0.409, 0.13, 1.65, and 6.09 pmol/g, respectively. After neoadjuvant therapy, the levels of E1, E2, E1S, ADIOL, and AONE were 0.002, 0008, 0.002, 2.22, and 5.63 pmol/g, respectively. The mean plasma levels of E1, E2, E1S, ADIOL, and AONE at base line were 621.5, 27.0, 1799.5, 1033, and 2258 pmol/l, respectively. After therapy, the levels of E1, E2, E1S, ADIOL, and AONE were 1.7, 1.6, 3.4, 1111, and 2826 pmol/l, respectively. LET significantly suppressed estrogens. Although plasma and tissue ADIOL ...
The major androgenic product secreted from the adrenal gland is DHEA. We have demonstrated recently that the major DHEA metabolite formed in human prostate tissue is adiol (4) . Our observation that adiol exists in PCa tissue after hormone therapy, as opposed to the decrease of DHT that occurs, is consistent with the possibility that adiol plays an important role in PCa progression after hormone therapy. This is supported additionally by the observation that adiol activates a mutated AR.. The presence of androgens in prostate tissue after androgen deprivation provides a mechanism through which the AR can be activated after therapy. Our results that DHT levels decrease by 75% are somewhat in conflict with a previous report that demonstrated androgen levels in PCa tissue decrease by only 50-60% after castration (13) . Perhaps methodologies account for these differences. Geller et al. (14) described that adrenal androgens DHEA and 4-dione contribute one-fifth to one-sixth of total DHT in prostate ...
The key conclusion from our data is that both gonadal and adrenal androgens are potent direct activators of ER-α. In the presence of androgens, ER-α transactivates a transfected reporter gene, down-regulates its own levels, and stimulates the proliferation of breast cancer cells. The latter finding suggests that androgens may be an important factor influencing breast cancer progression, notably in postmenopausal women.. Androgens have previously been shown to bind to ER-α directly by hormone binding assays. With ER-α overexpressed in COS cells, the affinities for E2, DHT, and testosterone have been determined to be 0.055 nm, 105 nm, and ,10 μm, respectively (12) . According to another study with in vitro synthesized ER-α, DHT, DHEA, ADIOL, and 3βD compete with half-maximal efficiency against E2 at 221, 245, 3.6, and 6 nm, respectively (13) . Direct binding to cell homogenates from ER-positive breast cancer cells has also been reported for ADIOL (14, 15, 16) , DHT, and DHEA (16) . ...
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The benefits of exercise on cognition have been demonstrated both in animals and humans. Exercise has salutary effects on glucoregulation and visceral adiposity, an important link for adults with impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). Exercise also upregulates neurotrophic activity, an effect that serves to increase neuronal viability in the same brain regions that support complex cognitive functions affected by metabolic disease. In this proposed controlled intervention trial, the hypothesis is that aerobic exercise will have a beneficial effect on cognition and several biomarkers that index disease progression for older adults with IGT. 40 older subjects (age: ,55 yrs) with IGT, confirmed by OGTT, will be randomized to an aerobic fitness or stretching program for 6 months. Cognitive measures and fasting blood samples will be obtained at baseline, month 3, and month 6. Cognitive tests will evaluate abilities affected by age and by significant glucoregulatory ...
Good news for lifelong exercisers: Physical activity helps to regenerate muscle mass, which tends to diminish as people age, along with its salutary effects on the heart, weight and other facets of health.
102848-54-4 - JIKFCHILHFFTSH-NRIFOQJISA-N - 4-Hydroxy-4-androstene-3,17-dione glucuronide - Similar structures search, synonyms, formulas, resource links, and other chemical information.
PRIMARY OBJECTIVES:. I. To determine the rate of pathologic complete response in patients with localized prostate cancer treated with androgen depletion therapy (ADT) and oral vorinostat administered for a minimum of 6 weeks and maximum of 8 weeks before radical prostatectomy.. SECONDARY OBJECTIVES:. I. To determine and evaluate pre- and post-treatment levels of prostate-specific antigen (PSA), testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and dehydroepiandrosterone-dulfate (DHEA-S) in blood.. II. To determine and evaluate pre- and post-treatment levels of testosterone, androstenedione, androstenediol, DHT, DHEA, and DHEA-S in prostate.. III. To determine and evaluate gene and protein expression analysis including androgen receptor (AR) target genes, PSA and TMPRSS2 (transmembrane protease, serine 2), in pre-treatment biopsy and post-treatment radical prostatectomy.. IV. To determine and evaluate exploratory gene microarray analysis. V. To determine and evaluate the ...
Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and therefore has a pivotal role in regulating the formation of biologically active steroids. The enzyme is widely distributed throughout the body, and its action is implicated in physiological processes and pathological conditions. The crystal structure of the enzyme has been resolved, but relatively little is known about what regulates its expression or activity. Research into the control and inhibition of this enzyme has been stimulated by its important role in supporting the growth of hormone-dependent tumors of the breast and prostate. STS is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone, respectively, both of which can be converted to steroids with estrogenic properties (i.e., estradiol and androstenediol) that can stimulate tumor growth. STS expression is increased in breast tumors and has prognostic significance. The ...
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Dehidroepiandrosteron (DHEA, Fidelin, androstenolon, prasteron, 3β-hidroksiandrost-5-en-17-on, 5-androsten-3β-ol-17-on) je važan endogeni steroidni hormon.[1] On je najzastupljeniji circulišući steroid kod ljudi,[2] kod kojih ga proizvode nadbubrežne žlezde,[3] gonade, i mozak,[4] gde on predominentno funkcioniše kao metabolički intermedijer u biosintezi androgena i estrogena seksualnih steroida.[1][5] Međutim, DHEA takođe ima raznovrsne samostalne potencijalne biološke efekte. On se vezuje za niz nuklearnih površinskih receptora,[6] i deluje kao neurosteroid.[7]. ...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron death. Development of effective therapies will require an understanding of the molecular and cellular mechanisms that go awry in the disease-insights that often come from genetic approaches. Mutational analyses of rare hereditary forms of ALS have already implicated ,12 culprit genes. Although several of these genes converge on common pathways, the overall view of pathogenesis remains incomplete.. Recent studies have uncovered two new genetic mutations that have an impact on ALS; interestingly, in one case the mutations appear to have a salutary effect on the course of the disease. Through exome sequencing of two large ALS families, Wu et al. discovered disease-associated mutations in the PFN1 gene, which encodes the actin-binding protein profilin-1. In cultured cells, mutant profilin-1 formed insoluble aggregates and inhibited axonal outgrowth. Starting with a zebrafish model of ALS, Van ...
Synthesis of 17b-hydroxy-androst-4-eno[3,2-c]pyrazole 3, 17b-hydroxy-androst-4-eno[3,2-c]-1 H-5 -methylthio-pyrazole 4, 17b-hydroxy-androst-4-eno[2,3-d]isoxazole 5, 17b-hydroxy-androst-4-eno[2,3-d] -1 H-3 -methylthio isoxazole 6, 17b-hydroxy-androst-4-eno[3,2-d]-2 -amino-6 -ethoxypyrimidine 7, 17b,2 -dihydroxy-androst-4-eno[3,2-d]- 6 -ethoxypyrimidine 8, and 17b-hydroxy-androst-4-eno[3,2-d]-2 -thiolo-6 -ethoxypyrimidine 9, 17b-hydroxy-4-androsteno[3,2-d]-2 -amino-6 -ethoxypyrimidine 10, 17b,2 -dihydroxy-4-androsteno[3,2-d]-6 ethoxypyrimidine 11, 17b-hydroxy-4-androsteno[3,2-d]-2 -thiolo-6 -ethoxypyrimidine 12, from 2-ethoxymethylene-4-androsten-3-one 1 and 2-bis (methylthio) methylene-4-androsten-3-one 2 are reported ...
A recent study shows some 1,150 deaths were tied to AED failures over a 15-year pe-riod, and nearly one in four of those failures were caused by problems with batteries. Dr. Deluca, the studys lead author, determined that 23.2 percent of the AED failures were due to battery/power failures, while 23.7 percent were due to problems with the pads or connectors.. Even though the report describes a variety of maintenance related problems, DeLuca is quick to note that AED failures appear to be very rare. "I dont want to send the mes-sage that these devices are unsafe or that they dont work," DeLuca said. "Most of the time they do work and they save lives.". AED batteries generally last up to five years. But it is important to implement an AED program that regularly checks for error mes-sages and could alert users about low batteries.. AED maintenance is key to having a successful AED program, step up and keep your AED program running smoothly. Visit ...
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Epidemiological field studies that are planned to evaluate associations between serum hormone levels and risk of cancer may require that many samples be analyzed over a period of months or years. The degree of variability in hormone assay results should be small enough so that the assay is likely to detect differences between cases and controls. In this study, we have obtained data on components of variability in androgen assay results. Such data allow one to assess the reproducibility of these assays and the measurements for epidemiological studies.. ADIOL G, DHEA, DHEA S, DHT, TESTO, and ADION were assayed in several laboratories. There was variation in the mean assay levels among the participating labs, but the correlations of rankings of subjects mean results among the labs were high. The CVs were fairly high and did not vary widely by menstrual or menopausal states. The CVs for measurements from lab 1 were usually ,15% but ranged to 20%, whereas those from lab 2 were usually ,20% but ...
Question - Having high DHEA-S levels and prescribed with dehydroepiandrosterone capsules. Is this ok ?. Ask a Doctor about uses, dosages and side-effects of Dehydroepiandrosterone capsules, Ask an Infertility Specialist
Learn more about Dehydroepiandrosterone (DHEA) at Aventura Hospital & Medical Center Supplement Forms/Alternate Names DHEA Sulfate Uses Principal Proposed...
Dehydroepiandrosterone (DHEA) is synthesized in the adrenals and the brain. Additionally, DHEA is produced at high concentrations in the human embryo enhancing neuronal development. Its production...
CAS: 15262-86-9 MF: C25H38O3 MW: 386.57 EINECS: 239-307-1 Synonyms: 17beta-hydroxyandrost-4-ene-3-one 4-methylvalerate;4-ANDROSTEN-17-BETA-OL-3-ONE ISOCAPROATE;4-ANDROSTEN-17BETA-OL-3-ONE ISOCAPRONATE;4-ANDROSTEN-17BETA-OL-3-ONE...
Learn more about Dehydroepiandrosterone (DHEA) at Kendall Regional Medical Center Supplement Forms/Alternate Names DHEA Sulfate Uses Principal Proposed Uses ...
DHEADehydroepiandrosterone (pronounced dee-hi-dro-epp-ee-ann-dro-stehr-own), or DHEA as it is more often called, is a steroid hormone produced in the adrenal gland. It is the most abundant steroid in the bloodstream and is present at even higher levels in brain tissue. Dehydroepiandrosterone levels are known to fall precipitously with age, falling 90% from age 20 to age 90. DHEA is known to be a precursor to
Testosterone (Steroids) Chemical name: 4-Androsten-17B-ol-3-one Synonyms:17beta-Hydroxyandrost-4-en-3-one CAS: 58-22-0 EINECS: 200-370-5 Assay: 98% min. Molecular formula: C19H28O2 Moleculare structure: Packing: foil bag or tin. Appearance: white...
Dehydroepiandrosterone (DHEA) is a steroid produced in the adrenal glands. It is converted in the body to testosterone and estrogen and acts similarly to ...
The IUPHAR/BPS Guide to Pharmacology. dehydroepiandrosterone ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
7 Keto DHEA has been thrown in the limelight recently a safe, healthy means to lose weight. 7 Keto DHEA is a natural derivative of dehydroepiandrosterone, or DHEA. ...
The remarkable underwater adhesion strategy employed by mussels has inspired bioadhesives that have demonstrated promise in connective tissue repair, wound closure, and local delivery of therapeutic cells and drugs. While the pH of oxygenated blood and internal tissues is typically around 7.4, skin and tumor tissues are significantly more acidic. Additionally, blood loss during surgery and ischemia can lead to dysoxia, which lowers pH levels of internal tissues and organs. Using 4-armed PEG end-capped with dopamine (PEG-D) as a model adhesive polymer, the effect of pH on the rate of intermolecular cross-linking and adhesion to biological substrates of catechol-containing adhesives was determined. Adhesive formulated at an acidic pH (pH 5.7-6.7) demonstrated reduced curing rate, mechanical properties and adhesive performance to pericardium tissues. Although a faster curing rate was observed at pH 8, these adhesives also demonstrated reduced mechanical and bioadhesive properties when compared to ...
250 µCi quantities of Androst-4-ene-3, [1,2,6,7-3H(N)]-, 17-Dione are available for your research. Application of [3H] Androstenedione can be found in: effects of HCG and PMS on bioconversion in steroid biochemistry, breast cancer cell research, inhibition study of human placental aromatase in steroid biochemistry, in vitro metabolism studies in steroid chemistry; etc. ...
Looking for dehydroepiandrosterone? Find out information about dehydroepiandrosterone. C19H28O2 Dimorphous crystals with a melting point of 140-141°C, or leaflet crystals with a melting point of 152-153°C; soluble in alcohol, benzene, and... Explanation of dehydroepiandrosterone
Delta-isomerase 2 (HSD3B2) which catalyzes the conversion of Dehydroepiandrosterone (DHEA) to androstenedione, a critical step in producing DHT from adrenal androgens, is also overexpressed at high levels [201]. Taken together, these data suggest a mechanism for how MCRPCa cells can continue to upregulate genes that require AR transactivation. The most obvious argument against this model is that t
Learn more about Dehydroepiandrosterone (DHEA) at Blake Medical Center Supplement Forms/Alternate Names DHEA Sulfate Uses Principal Proposed Uses ...
Learn more about Dehydroepiandrosterone (DHEA) at Blake Medical Center Supplement Forms/Alternate Names DHEA Sulfate Uses Principal Proposed Uses ...
Low prices on DHEA! DHEA may help prevent the onset of symptoms related to the aging process*. DHEA (dehydroepiandrosterone) is a hormone produced in the body and secreted by the adrenal glands. DHEA levels can decline as we age. DHEA can be converted to testosterone and estrogen as needed depending on your gender, age, or health status.*
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Dehydroepiandrosterone, or DHEA, is a naturally occurring hormone that may promote brain health, muscle growth, and energy. It is secreted by the adrenal gland and serves as a precursor to testosterone and estrogen.. ...
Dehydroepiandrosterone, or DHEA, is a naturally occurring hormone that may promote brain health, muscle growth, and energy. It is secreted by the adrenal gland and serves as a precursor to testosterone and estrogen.. ...
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DHEA is also known as androstenolone, 3β-hydroxyandrost-5-en-17-one and 5-androsten-3β-ol-17-one. It is an endogenous steroid hormone; in other words, it is
DHEA 25 mg 100 caps ProThera contains pure DHEA that has been micronized to a very small particle size to facilitate absorption. Vegetarian capsules made of plant cellulose are used ...
Under stress, the adrenal glands secrete extra dehydroepiandrosterone (DHEA). In one study, researchers measured how different levels of DHEA affected performance under stress. Researchers checked DHEA blood levels in 41 healthy soldiers the day before the men began a month-long combat diver training course. Men with higher DHEA levels performed better during the final nighttime underwater navigation test than men with lower levels. Underwater navigation relies on an area of the brain called the hippocampus, which has stress receptors DHEA regulates. Researchers believe the findings help explain why soldiers handle stress differently, and that compounds like DHEA may help protect them in the future. Reference: ...
A Southern Colorado teen collapses during his wrestling match. The only reason he is alive today is due to CPR and the shock from an AED.
Patent No. US 6,994,864 B2: LOréal, Paris has patented a composition comprising a physiologically acceptable medium; at least one DHEA derivative; selected from the group consisting of 7-hydroxy-DHEA and 7-keto DHEA; and at least one ca
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This study suggests that a modest association exists between pretreatment levels of androstenedione, an adrenal androgen, and response to ketoconazole, as well as overall survival in patients with AIPC who are treated with ketoconazole. These data, from a multicenter randomized trial, contrast with prior data from a smaller trial of 28 patients, which showed no correlation between baseline levels of any adrenal androgens and response to ketoconazole (13).. In the present analysis, baseline levels of these adrenal androgens in patients treated with ketoconazole initiated at the time of AAWD (arm 2) were studied and correlated to clinical outcomes. The primary focus was the ketoconazole arm of the study because this drug exerts its effect through suppression of adrenal androgens and because, in a prior analysis of the same data set, no change in adrenal androgen levels was observed over time in the AAWD alone arm (6). All demographic and baseline clinical data from the patients randomized to arm 2 ...
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Purpose: Abnormalities in both cortisol and dehydroepiandrosterone (DHEA) have been reported in psychiatric disorders. measure which may reflect environmental stress. More work is required to further validate this technique which may prove useful in studies of both healthy individuals and patient groups. = 0.38) or DHEA (U = 131, = 0.88) using the two pilot extraction protocols. Cortisol was significantly correlated with DHEA at both visits (= 0.001 and 0.001, r = 0.510 and 0.583, 11056-06-7 respectively; Figures 1 and ?and2).2). The two women on combined oral hormone contraception were not outliers in any of these analyses. No traceable amounts of cortisol or DHEA were detected in methanol from the additional extraction or in isopropanol (Data not shown). Figure 1 Correlation plots of the cortisol and DHEA concentrations at baseline visit. Cortisol denotes nail cortisol levels to the beginning of the school period and DHEA denotes the nail DHEA levels to the beginning of the school period. Note ...
English Synonyms: DELTA5-PREGNEN-3BETA-OL-20-ONE;DELTA5-PREGNEN-3B-OL-20-ONE;DELTA-5-PREGNENE-3B-OL-20-ONE;DELTA5-PREGNENOLONE;1-((3S,8S,9S,10R,13S,14S,17S)-3-HYDROXY-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-ETHANONE;3BETA-HYDROXY-5-PREGNEN-20-ONE;3BETA-HYDROXYPREGN-5-EN-20-ONE;3b-hydroxy-5-pregnen-20-one ...
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Dehydroepiandrostenedione (more correctly didehydroepiandrosterone), also known as androstenolone or prasterone, as well as 3β-hydroxyandrost-5-en-17-one or 5-androsten-3β-ol-17-one, is an important endogenous steroid hormone. It is the most abundant circulating steroid hormone in humans, in whom it is produced in the adrenal glands, the gonads, and the brain, [4] where it functions predominantly as a metabolic intermediate in the biosynthesis of the androgen and estrogen *** steroids. However, Dehydroisoandrosterone also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a neurosteroid. Dehydroisoandrosterone Usage ...
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Chemicals. Radiolabeled [4-14C]fluasterone (lot 9676-29-07 from Midwest Research Institute, Kansas, MO) had a radiochemical purity of approximately 97% and specific activity of 58.3 mCi/mmol. Fluasterone (lot 99973-1/91) was supplied by Proquina (Orizaba, Mexico). Standards of 16α-fluoro-5-androsten-17β-ol (17β-OH fluasterone) and 16α-fluoro-5-androsten-17α-ol (17α-OH fluasterone) were supplied by Dr. Marvin L. Lewbart (Department of Medicine, Jefferson Medical College, Philadelphia, PA). Sulfatase-free β-glucuronidase, bacterial from Escherichia coli, was supplied with phosphate buffer Sigma G8396 (Sigma-Aldrich, St. Louis, MO). β-Glucuronidase-free sulfatase, type VI, from Aerobacter aerogenes was supplied with 0.01 M Tris, pH 7.5, Sigma S1629 (Sigma-Aldrich). Soluene-350 tissue solubilizer and Ultima Gold scintillation mixture were purchased from PerkinElmer Life and Analytical Sciences (Waltham, MA).. Dosing and Collection of Biological Samples. Groups of male beagle dogs received ...
Used for efficient production of key steroid intermediates (androst-4-ene-3,17-dione, androsta-1,4-diene-3,17-dione, 9-hydroxy androst-4-ene-3,17-dione) from phytosterol ...
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This study shows that limbic seizures that are relatively resistant to AED treatment (Reynolds, 1987; Hauser and Hesdorffer, 1990; Loscher, 1997) induce mdr1 mRNA to a large extent in limbic areas. This increase appears to be specific, becausemrp1, a different P-gp involved in MDR (Zaman et al., 1994), was unchanged. Mdr1 mRNA overexpression in kainate-injected mice was transient but outlasted their acute seizures by several hours, suggesting that ongoing epileptic activity may result in sustained increase of this protein.. This was confirmed by measuring mdr1 mRNA levels in epileptic tissue from spontaneously epileptic rats. Thus, in these animals mdr1 mRNA expression was enhanced 3 months after the acute SE both in the hippocampus, where seizures were initially triggered, and in the entorhinal cortex, an area involved in seizure generalization and spread (Fountain et al., 1998). These findings clearly indicate that spontaneously recurring limbic seizures are associated with elevated levels of ...
Learn more about Dehydroepiandrosterone (DHEA) at TriStar Centennial Supplement Forms/Alternate Names DHEA Sulfate Uses Principal Proposed Uses ...
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What is the best product name,brand ect of DHEA I have been using it for a few years 100mg ED.I have been taking the Vitamin World brand but not
Find patient medical information for DHEA on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that have it.

Androstenediol - The MarketAndrostenediol - The Market

Androstenediol/Lab Interactions:*Hormone levelsHormone levels: Based on clinical studies, androstenediol may increase estradiol ... Androstenediol/Herb/Supplement Interactions:*AntibacterialsAntibacterials: The immune boosting effects of androstenediol in ... this therapy may decrease plasma androstenediol and androstenediol free index levels, despite a lack of effects on the ... Androstenediol/Drug Interactions:*Aminoglutethimide-plus-hydrocortisone therapyAminoglutethimide-plus-hydrocortisone therapy: ...
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b. Endogenous** AAS when administered exogenously: androstenediol (androst-5-ene-3 ,17 -diol); androstenedione (androst-4-ene-3 ... 4-androstenediol (androst-4-ene-3 ,17 -diol); 5-androstenedione (androst-5-ene-3,17-dione); epi-dihydrotestosterone; ...
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Androstenediol - WikipediaAndrostenediol - Wikipedia

Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous ... This article is about androstenediol the hormone. For other uses, see Androstenediol (disambiguation). ... Androstenediol, also known as androst-5-ene-3β,17β-diol, is a naturally occurring androstane steroid.[5] It is closely related ... Androstenediol is a direct metabolite of the most abundant steroid produced by the human adrenal cortex, DHEA. It is less ...
more infohttps://en.wikipedia.org/wiki/5-Androstenediol

Androstenediol - DrugBankAndrostenediol - DrugBank

Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), ... 5-Androstenediol. PDB Entries. 3klp. Clinical Trials. Clinical Trials Not Available. Pharmacoeconomics. Manufacturers. Not ... Androstenediol. Accession Number. DB01524. Type. Small Molecule. Groups. Experimental, Illicit. Description. An intermediate in ... Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), ...
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Androstenediol - WikipediaAndrostenediol - Wikipedia

Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous ... Androstenediol, also known as androst-5-ene-3β,17β-diol, is a naturally occurring androstane steroid. It is closely related ... Although androstenediol has far lower affinity for the ERs compared to the major estrogen estradiol, it circulates at ... Androstenediol possesses potent estrogenic activity, similarly to DHEA and 3β-androstanediol. It has approximately 6% and 17% ...
more infohttps://en.wikipedia.org/wiki/Androstenediol

4-Androstenediol - Wikipedia4-Androstenediol - Wikipedia

4-Androstenediol, also known as androst-4-ene-3β,17β-diol, is an androstenediol that is converted to testosterone. The ... 4-Androstenediol is closer to testosterone structurally than 5-androstenediol, and has androgenic effects, acting as a weak ... 4-androstenediol has antagonistic actions, behaving more like an antiandrogen. 4-Androstenediol is very weakly estrogenic. It ... Patrick Arnold holds a 1999 patent on "Use of 4-androstenediol to increase testosterone levels in humans". Chen F, Knecht K, ...
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Androstenediol  | YourCareEverywhereAndrostenediol | YourCareEverywhere

4-androstenediol, 5-androstenediol, (Adiol), alpha-androstenediol, "Andro" prohormones, androstenediol 3-sulfate (ADIOLS), ... Androstenediol may interact with anticancer agents. Androstenediol may stimulate the growth of breast cancer cells and exert ... Androstenediol may interact with anticancer agents. Androstenediol may stimulate the growth of breast cancer cells and exert ... Serum concentrations of androstenediol and androstenediol sulfate, and their relation to cytokine production during and after ...
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Androstenediol - Wild By Nature - HuntingtonAndrostenediol - Wild By Nature - Huntington

4-androstenediol, 5-androstenediol, (Adiol), alpha-androstenediol, "Andro" prohormones, androstenediol 3-sulfate (ADIOLS), ... Androstenediol may interact with anticancer agents. Androstenediol may stimulate the growth of breast cancer cells and exert ... Androstenediol may interact with anticancer agents. Androstenediol may stimulate the growth of breast cancer cells and exert ... Serum concentrations of androstenediol and androstenediol sulfate, and their relation to cytokine production during and after ...
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The role of androst-5-ene-3 beta,17 beta-diol (androstenediol) in cell proliferation in endometrium of women with polycystic...The role of androst-5-ene-3 beta,17 beta-diol (androstenediol) in cell proliferation in endometrium of women with polycystic...

The role of androst-5-ene-3 beta,17 beta-diol (androstenediol) in cell proliferation in endometrium of women with polycystic ... The role of androst-5-ene-3 beta,17 beta-diol (androstenediol) in cell proliferation in endometrium of women with polycystic ...
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You Could Grow BreastsYou Could Grow Breasts

Androstenediol. Another hormone (like androstenedione and DHEA) that your body creates as a precursor to testosterone and that ...
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Overcome Sexual Problems With Prosexual Vitamins & Nutrients - Us Smart PublicationsOvercome Sexual Problems With Prosexual Vitamins & Nutrients - Us Smart Publications

Androstenedione and Androstenediol:a safe way to restore declining testosterone. To combat problems associated with low ... In summary: The new, androstenediol spray is an extremely safe and effective way for both men and women to raise their ...
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Collection : Papers from the Study of Womens Health Across the Nation (SWAN) : MenopauseCollection : Papers from the Study of Women's Health Across the Nation (SWAN) : Menopause

Androstenediol complements estrogenic bioactivity during the menopausal transition. Lasley, Bill L.; Chen, Jiangang; Stanczyk, ... Androstenediol contributes to circulating estrogenicity when estradiol production falls at menopause and may contribute ...
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Androgen - WikipediaAndrogen - Wikipedia

Androstenediol (A5) is the steroid metabolite thought to act as the main regulator of gonadotropin secretion.[citation needed] ...
more infohttps://en.wikipedia.org/wiki/Androgen

21 U.S. Code § 802 - Definitions | US Law | LII / Legal Information Institute21 U.S. Code § 802 - Definitions | US Law | LII / Legal Information Institute

iii) androstenediol- (I) 1-androstenediol (3β,17β-dihydroxy-5α-androst-1-ene); ... 1-androstenediol (3α,17β-dihydroxy-5α-androst-1-ene); ... 19-nor-5-androstenediol (3β, 17β-dihydroxyestr-5-ene); and ...
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Text of S. 2195 (108th): Anabolic Steroid Control Act of 2004 (Passed Congress version) - GovTrack.usText of S. 2195 (108th): Anabolic Steroid Control Act of 2004 (Passed Congress version) - GovTrack.us

I) 1-androstenediol (3b,17b-dihydroxy-5a-androst-1-ene);. (II) 1-androstenediol (3a,17b-dihydroxy-5a-androst-1-ene); ...
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Fatty AlcoholFatty Alcohol

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The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester | SpringerLinkThe human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester | SpringerLink

11-dehydrocorticosterone and Δ5-androstenediol. Deuterated progesterone (4-pregnen-3,20-dione-2,2,4,6,6,17α,21,21,21-d9; ...
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Not Allowed ListNot Allowed List

1-Androstenediol. *1-Butyl-3-(1-Naphthoyl)Indole. *1-Dimethylamino-1,2-Diphenylethane ...
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post by virrasztopost by virraszto

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Your guide to banned substances | Health24Your guide to banned substances | Health24

Dehydroepiandrosterone (DHEA); androstenedione; androstenediol. The effect of tribulus terrestris, herbal testosterone ...
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Sex hormone-binding globulin - WikipediaSex hormone-binding globulin - Wikipedia

Androstenediol. 97. 1500. 4.3. 3.24. 60.4. ,0.1. 36.3. 2.4. 1.73. 78.8. ,0.1. 19.4 ... The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) , testosterone , androstenediol , ...
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  • Due to a lack of human benefit and the potential for negative health effects, the risk to benefit ratio of using androstenediol and other prohormone substances seems unfavorable. (yourcareeverywhere.com)
  • Although androstenediol has far lower affinity for the ERs compared to the major estrogen estradiol , it circulates at approximately 100-fold higher concentrations, and so is thought may play a significant role as an estrogen in the body. (wikipedia.org)
  • Estrone (E1) and dehydroepiandrosterone can be formed from E1 sulfate (E1S) and dehydroepiandrosterone sulfate, respectively, and can be reduced to steroids with potent estrogenic properties, estradiol (E2) and androstenediol, by 17β-hydroxysteroid dehydrogenase type 1, which is present in breast tissues ( 3 ). (aacrjournals.org)
  • This is not steroids ) are chemically modified versions or derivatives of the naturally-occurring male sex endogenous androgen, androstenediol, also binds to oestrogen receptors. (shaycarl.com)