Derivatives of the steroid androstane having three double bonds at any site in any of the rings.
Unsaturated androstanes which are substituted with one or more hydroxyl groups in any position in the ring system.
The science that investigates the principles governing correct or reliable inference and deals with the canons and criteria of validity in thought and demonstration. This system of reasoning is applicable to any branch of knowledge or study. (Random House Unabridged Dictionary, 2d ed & Sippl, Computer Dictionary, 4th ed)
The branch of psychology which seeks to learn more about the fundamental causes of behavior by studying various psychologic phenomena in controlled experimental situations.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
A sterol usually substituted with radioactive iodine. It is an adrenal cortex scanning agent with demonstrated high adrenal concentration and superior adrenal imaging.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

Estrogen synthesis in fetal sheep brain: effect of maternal treatment with an aromatase inhibitor. (1/20)

The aim of the present study was to determine whether the fetal lamb brain has the capacity to aromatize androgens to estrogens during the critical period for sexual differentiation. We also determined whether administration of the aromatase-inhibitor 1,4,6-androstatriene-3,17-dione (ATD) could cross the placenta and inhibit aromatase activity (AA) in fetal brain. Eight pregnant ewes were utilized. On Day 50 of pregnancy, four ewes were given ATD-filled Silastic implants, and the other four ewes received sham surgeries. The fetuses were surgically delivered 2 wk later (Day 64 of gestation). High levels of AA (0.8-1.4 pmol/h/mg protein) were present in the hypothalamus and amygdala. Lower levels (0.02-0.1 pmol/h/mg protein) were measured in brain stem regions, cortex, and olfactory bulbs. The Michaelis-Menten dissociation constant (K(m)) for aromatase in the fetal sheep brain was 3-4 nM. No significant sex differences in AA were observed in brain. Treatment with ATD produced significant inhibition of AA in most brain areas but did not significantly alter serum profiles of the major sex steroids in maternal and fetal serum. Concentrations of testosterone in serum from the umbilical artery and vein were significantly greater in male than in female fetuses. No other sex differences in serum steroids were observed. These data demonstrate that high levels of AA are found in the fetal sheep hypothalamus and amygdala during the critical period for sexual differentiation. They also demonstrate that AA can be inhibited in the fetal lamb brain by treating the mother with ATD, without harming fetal development.  (+info)

Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action. (2/20)

It has been shown previously that female mice homozygous for an alpha-fetoprotein (AFP) null allele are sterile as a result of anovulation, probably due to a defect in the hypothalamic-pituitary axis. Here we show that these female mice exhibit specific anomalies in the expression of numerous genes in the pituitary, including genes involved in the gonadotropin-releasing hormone pathway, which are underexpressed. In the hypothalamus, the gonadotropin-releasing hormone gene, Gnrh1, was also found to be down-regulated. However, pituitary gene expression could be normalized and fertility could be rescued by blocking prenatal estrogen synthesis using an aromatase inhibitor. These results show that AFP protects the developing female brain from the adverse effects of prenatal estrogen exposure and clarify a long-running debate on the role of this fetal protein in brain sexual differentiation.  (+info)

Rainbow trout gonadal masculinization induced by inhibition of estrogen synthesis is more physiological than masculinization induced by androgen supplementation. (3/20)

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Sex differences and effects of neonatal aromatase inhibition on masculine and feminine copulatory potentials in prairie voles. (4/20)

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Involvement of estradiol-17beta and its membrane receptor, G protein coupled receptor 30 (GPR30) in regulation of oocyte maturation in zebrafish, Danio rario. (5/20)

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Estradiol shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression. (6/20)

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wnt4 Is associated with the development of ovarian tissue in the protandrous black Porgy, Acanthopagrus schlegeli. (7/20)

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Testosterone restores respiratory long term facilitation in old male rats by an aromatase-dependent mechanism. (8/20)

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Procedure: The investigators determined the susceptibility to central breathing instability by mechanically ventilating the subjects during NREM sleep using non-invasive pressure support ventilation. The investigators compared the hypocapnic apneic threshold in old (age,60 years) and young (age 18-50 years) individuals who were healthy. The investigators also measured the parameters over a continuum of age from 18 to 89 years.. - The investigators investigated whether there was a difference in the susceptibility to long term facilitation of ventilation between young and old healthy individuals in response to episodic hypoxia, while maintaining isocapnia.. Sleep apnea is very common in older Veterans and is associated with significant cardiovascular complications. Greater insight into the pathogenesis will have a positive impact on the health of Veterans suffering from this condition. This study furthers the understanding of the pathogenesis of breathing instability leading to sleep-disordered ...
CAS 4642-95-9 Trenavar Product Name: Trenavar, Trendione Alias: Celtitren Chemical Name: Estra-4,9,11-triene-3,17-dione CAS NO.: 4642-95-9 Molecular Formula: C18H20O2 Molecular Weight: 268.3502 Purity: 99% Grade: Pharmaceutical Grade Appearance:...
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The |i|Journal of Biomedical Optics|/i| (JBO) publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
This seven-part video tutorial will take you through the steps necessary to dissecting a sheep brain so we can learn and compare it to a human brain. Youll learn about the different kinds of memory in the brain, and thats not all. So, for this science anatomy of the brain dissection project, go down to the local slaughterhouse and get yourself a brain. Abattoirs are a great place for brains. Dissect a sheep brain to compare to a human brain - Part 1 of 7. Click through to watch this video on exploratorium.edu Dissect a sheep brain to compare to a human brain - Part 2 of 7. Click through to
Other names: Silane, [[(16«beta»,17«alpha»)-estra-1,3,5(10)-triene-3,16,17-triyl]tris(oxy)]tris[trimethyl-; Silane, [[(16«beta»,17«alpha»)-estra-1,3,5(10)-triene-3,16,17-triyl]tris(oxy)]tris*trimethyl-; 3,16«beta»,17«alpha»-Trihydroxy-1,3,5(10)-estratriene 3,16,17-tms; 16-Epiestriol, 3,16,17-tris(trimethylsilyl) ether; 16-epi-Estriol, TMS ...
Nimbus, shown below in photos, was a well cared for 2 year 2 month old male rat. He presented with hind limb paresis, but was in otherwise relative good health with no known injuries. He was adequately housed, and allowed free time outside the cage. Exercise time was supervised with other male cage mates. He was maintained on a varied and nutritious diet along with supplemental treats ...
A denitrifying bacterium, designated strain FS T , was isolated from anoxic digested sludge on oestradiol [17 β -oestra-1,3,5(10)-triene-3,17-diol] or testosterone (17 β -hydroxyandrost-4-en-3-one) as the sole source of carbon and energy with nitrate as
Fenoldopam Fenoldopam Systematic (IUPAC) name 8-chloro-2-(4-hydroxyphenyl)- 4-azabicyclo[5.4.0] undeca-7,9,11-triene-9,10-diol Identifiers CAS number
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Wards® pure preserved specimens-the best dissection experience from start to finish.Preserved specimens are delivered in sealed containers for long-lasting viability in transit, and arrive ready to be used for dissection purposes. Whole organisms or discrete organs are available, with skinned specimens all maintaining intact and undamaged internal organs. High-quality preserved specimens are packed in a variety of containers depending on size and intended use, and a vast selection of species sourced from the land, air, and sea are available for clinical or classroom dissection.
I am curious if anyone experienced any sides from using erase? I have had great results in the past using ATD. I have had some bad experiences with
According to Tom Brimeyer M.S., in order to properly address hypothyroidism, one must address all facets of thyroid health and the thyroid hormone pathway. This includes several steps, which he explains are: Addressing the ENTIRE thyroid hormone pathway: The intricate thyroid hormone pathway we explained before has to be taken into account. The key is…
Incredibly Weird Facts Youll Want To Impress a Lady with. A female ferret will die if she doesnt have sex for a year and more...
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Estriol (E3), los yog oestriol, los yog hu ua 16a-hydroxyestradiol los yog estra-1,3,5 (10) -triene-3,16α, 17β-triol, yog ib qho tshuaj steroidal estrogen thiab ib qho ntawm peb lub ntsiab estrogens tib neeg lub cev.Khov khoom ntawm estriol los ntawm zes qe menyuam yog yuav luag undetectable rau cov poj niam uas tsis xeeb tub. Txawm li cas los xij, thaum lub cev xeeb tub, estriol yog muab los ntawm qhov chaw tshee hnyav heev thiab nyob deb ntawm cov tshuaj ua rau lub cev feem ntau, txawm hais tias cov qib qis yog zoo li cov lwm cov estrogens vim tias muaj feem ntau ntawm cov metabolism thiab kev qias neeg.
This summer Ive been collecting lymph nodes and brain stems for the Regulatory Scrapie Slaughter Surveillance (RSSS). After collection these tissue samples are sent to another lab for scrapie testing. Due to the lamb market seeing record prices there are less animals moving through Michigan slaughter facilities. Luckily this summer Ive had the opportunity to…
I have read where ATD causes a postive drug test for Boldenone because it has metabolites that are the same as the boldenone metabolites that they
Jaroslav Trone ek, Brno - abov esky, Firma prov d zednick a obklada sk pr ce. Rekonstrukce byt a koupelen, podlah sk pr ce atd. - Evropsk databanka
Hydracrylic acid, 2-(p-cyclohexylphenyl)-3-phenyl-, (R*,S*)-(-)- Carbonic dichloride, polymer with 4,4-(1-methylethylidene)bis(2,6-dibromophenol) and 4,4-(1-methylethylidene)bis(phenol), 4-(1-methyl-1-phenylethyl)phenyl ester (2-dimethylaminophenyl)-diphenyl-methanol 3-chloro-9-methyl-N-propyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine 1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-, polymer with 1,3-butanediol and oxybis(propanol) 9-chloro-2,5-diazabicyclo[5.4.0]undeca-8,10,12-triene-3,6-dione Resin acids and Rosin acids, polymd, yttrium salts 2-benzyl-7-ethylamino-8-thia-2,4,9-triazabicyclo[4.3.0]nona-6,9-diene-3,5-dione ethyl 6-amino-5-cyano-4-(4-ethylphenyl)-2-propyl-4H-pyran-3-carboxylate Bicyclo(4.1.1)oct-3-ene
This sheep brain specimen teaches students about cranial nerves and how our own brains are wired. Ready for dissection. Buy your preserved sheep brain here.
feminine Definition, feminine Best Plays of feminine in Scrabble® and Words With Friends, Length tables of words in feminine, Word growth of feminine, Sequences of feminine
Accepted name: 3-ketosteroid 9α-monooxygenase. Reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9α-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O. Other name(s): KshAB; 3-ketosteroid 9α-hydroxylase. Systematic name: androsta-1,4-diene-3,17-dione,NADH:oxygen oxidoreductase (9α-hydroxylating). Comments: The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It is a two-component system consisting of a terminal oxygenase (KshA) and a ferredoxin reductase (KshB). The oxygenase contains a Rieske-type iron-sulfur center and non-heme iron. The reductase component is a flavoprotein containing an NAD-binding domain and a plant-type iron-sulfur cluster. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: References:. 1. Petrusma, M., Dijkhuizen, L. and ...
A denitrifying bacterium, designated strain FS(T), was isolated from anoxic digested sludge on oestradiol [17beta-oestra-1,3,5(10)-triene-3,17-diol] or testosterone (17beta-hydroxyandrost-4-en-3-one) as the sole source of carbon and energy with nitrate as the electron acceptor. Strain FS(T) represents the first known bacterium to grow anaerobically on both oestradiol (C-18) and testosterone (C-19). Steroidal hormones were degraded completely by nitrate reduction to dinitrogen monoxide, which was further reduced to dinitrogen in stationary-phase cultures. Gram-negative cells were slightly curved rods, 0.3-0.5 x 0.6-1.6 microm in size, motile, non-fermentative, non-spore-forming and catalase- and oxidase-positive, showing optimal growth at pH 7.0, 28 degrees C and 0.1% (w/v) NaCl. Beside steroidal hormones, the bacterium utilized only a narrow range of organic substrates with nitrate as the electron acceptor, including several fatty acids and glutamate. No aerobic or anaerobic growth occurred on ...
Sigma-Aldrich offers abstracts and full-text articles by [Leanne K Hein, Tina Rozaklis, Melissa K Adams, John J Hopwood, Litsa Karageorgos].
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This case study demonstrates how Always, a feminine pad brand manufactured by P&G, an American multinational consumer goods company, set out to change the meaning of the common playground insult like a girl to demonstrate that Always could do more than offer protection during a girls period. ...
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Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more: Dr. Waghmarae on feminine soreness: Yes. You may have a problem with that. Finding an alternate may be difficult. If your symtoms are very mild or more theoretical than real you may be able to by with using this method.
Pivot, our undescented female ferret, is two today. A note on ferrets - they are related to skunks. Things can get a bit smelly if she gets unduly excited or frightened. You learn to keep your distance when she her...
Weve collected a lot of pictures during our BrainSTEM lessons. Below are a few of our best. Brain Dissections! On the day we were to do sheep brain dissections, the power went out at KIPP Sunnyside. While this was initially a set back (we preferred to not work with sharp instruments in a dark room),…
CAS NO:4733-52-2; Chemical name:2,3-benzodioxine-1,4-dione ; physical and chemical property of 4733-52-2, 2,3-benzodioxine-1,4-dione is provided by ChemNet.com
Aplastic anemia is a condition in which the bone marrow is completely suppressed, resulting in a shutdown in production of new red blood cells. Bone marrow suppression will also result in a shutdown in production of white blood cells and platelets. The condition occurs in female ferrets that are not spayed and not bred when they are in heat. Sexually mature female ferrets that are not bred will stay in heat indefinitely. While in heat, the ferrets estrogen levels remain high. High doses of estrogen suppress bone marrow function. This condition is rarely seen now, due to early (pre-purchase) spaying of female ferrets.. Signs of aplastic anemia include lethargy and pale mucous membranes, most readily observed by looking at the gums. When the intact female ferret is examined, her vulva will usually be found to be swollen and enlarged, indicating persistent estrus or heat.. Initial treatment to stabilize the ferret includes hormonal therapy to bring the ferret out of heat, antibiotics, iron, and ...
with 30 day old male rats pairfed for 10 days with lactalbumin as a control diet or lactalbumin plus PHA or purified soybean trypsin inhibitor (STI) as a positive control (42 mg/rat/day) with or without 20 micrograms of the cholecystokinin A (CCK-A) antagonist MK 329, also found that oral administration of phytohaemagglutinin (PHA) in rats dose dependently induces growth of the small intestine through significantly increased CCK plasma levels from 0.75 to 6.67 (SEM 2.23) compared with 2.3 (0.35) pM in the control group ...
Food (cassava) linamarin is metabolized into neurotoxicants cyanide and cyanate, metabolites of which we sought to elucidate the differential toxicity effects on memory. Young 6-8 weeks old male rats were treated intraperitoneally with either 2.5 mg/kg body weight (bw) cyanide (NaCN), or 50 mg/kg bw cyanate (NaOCN), or 1 μl/g bw saline, daily for 6 weeks. Short-term and long-term memories were assessed using a radial arm maze (RAM) testing paradigm. Toxic exposures had an influence on short-term working memory with fewer correct arm entries (F 2, 19 = 4.57 p , 0.05), higher working memory errors (WME) (F 2, 19 = 5.09, p , 0.05) and longer RAM navigation time (F 2, 19 = 3.91, p , 0.05) for NaOCN relative to NaCN and saline treatments. The long-term working memory was significantly impaired by cyanide with fewer correct arm entries (F 2, 19 = 7.45, p , 0.01) and increased working memory errors (F 2, 19 = 9.35 p , 0.05) in NaCN relative to NaOCN or vehicle treated animals. Reference memory was not ...
With female ferrets subjected to different degrees of intensity of light irradiation as measured by placing them at different distances from a 1000 W. lamp, the acceleration of the oestrous cycle, generally speaking, was correlated with the degree of intensity. There were, however, individual exceptions. The distances between the ferrets and the lamp varied from 1 to 22 ft.. Female ferrets subjected to ultra-violet irradiation usually remained on heat until much later in the year than those submitted to light irradiation. With male ferrets ultra-violet irradiation caused descent of the testes in December and the testes remained descended until the autumn.. Irradiated female ferrets (both with light and ultra-violet rays) went off heat shortly after being put with males and probably as a result of copulation (which, however, was not always observed), but pregnancy did not supervene. This may have been due to the animals not being in a state for ovulation.. Feeding vitamin D to anoestrous ferrets ...
Trendione (developmental code name RU-2065; nickname Trenavar), also known as estra-4,9,11-triene-3,17-dione, is an androgen prohormone as well as metabolite of the anabolic steroid trenbolone.[1][2][3][4][5] Trendione is to trenbolone as androstenedione is to testosterone.[6] The compound is inactive itself, showing more than 100-fold lower affinity for the androgen and progesterone receptors than trenbolone.[7][8] It is a designer steroid and has been sold on the internet as a nutritional supplement.[1] Trendione is listed in the United States Designer Anabolic Steroid Control Act of 2014.[1] ...
Estradiol Valerate Synonyms:3,5(10)-triene-3,17-diol(17-beta)-estra-17-pentanoate;atladiol;b-estradiol17-valerate;deladiol;delahormoneunimatic;delestrogen;delestrogen4x;dura-estradiol CAS:979-32-8 MF: C23H32O3 MW:356.5 EINECS: 213-559-2...
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Q: Ive not too long ago adopted one feminine and two male guinea pigs. They are throughout 2 months outdated. Im ready for the boys to be the best weight to have them fastened. Im too scared to have the feminine fastened in case she is already pregnant. Once the males are fastened, will they depart my little feminine alone? They at the moment comply with her far and wide. I wish to add one other feminine to the group as soon as the boys are fastened, however I dont need to do this if its going to trigger fights. They have greater than sufficient room to roam and play of their two-level, split-level home with loads of hidey-holes.. A: Having a male guinea pig fastened is not going to change his pure propensity to need to mate with the feminine. It will solely insure that there isnt any conception after the act. In the scenario you describe, having just one feminine who will cycle each 17 days means she is not going to solely have the undesirable advances of 1 male, however she might be ...
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Can type have a gender? Is it even socially acceptable to ask such as question? Putting aside any sort of nonsensical gender bias, its absolutely the case that typography can and does suggest a level of masculinity (or a lack thereof). Today, were going to jump into what makes a typeface feminine vs. masculine. More...
Our culture has had a long heritage of associating the feminine principle with what it means to be female and the masculine principle with what it means to be male. As a result, both men and women have traditionally been locked into rigid culturally-defined gender roles that have not been helpful for anyone who wishes to live a more meaningful, creative, and soul-making life...
Aromatase inhibitors information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
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Results:. 37,04% of the sample (108 elders) had falls, predominating over the feminine sex. 55% of the falls was only; the rest was repetition falls. They predominated over the falls happened in the morning, in the room, produced by loss of balance and that they didnt cause apparent hurts. A significantly statistical relation was observed between the falls and the cognitive condition; but not between falls and: the polymedication, the functionality and the mobility. Very different trends were observed between fallen elders and elders without falls. ...
I believe that were at a pivotal time in our history, where we get to rewrite the script to create a better world. A vision of a World that is kinder, supportive and compassionate, by embracing and embodying the feminine as a guide to becoming familiar with who we already are. As we become familiar with who we already are, we become gentler versions of ourselves and gentler on others. We all have a role to play ...
Lilith in Sagittarius is the pure expression of the wild, unleashed feminine spirit. Break free from whatever chains are holding you back!
I dont do much drawing anymore - i seem to have grown out of trying to construct feminine worlds inside the boundaries of A4 sheets of paper. (plus who has the time when youre trying to pass ten subjects at once?) These days i am focusing on taking pictures of flowers instead because they are the truest and most beautiful things. One day ill go back to the paintbrush - but itll be different because now i see things differently ...
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Androstatrienes/metabolism*. *Androstatrienes/pharmacology. *Androstenes/metabolism*. *Androstenes/pharmacology. *Aromatase/ ...
Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Small-molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17; 40(4):477-89 ...
Androstatrienes D4.808.54.79.229 D4.210.500.54.79.229 Androstenediol D4.808.54.79.429.154.50 D4.210.500.54.79.429.154.50 ...
Androgens, Androstatrienes, Androstenedione, Animals, Aromatase Inhibitors, Brain, Dihydrotestosterone, Enzyme Inhibitors, ...