Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.Chrysenes: 1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.Gene Products, tat: Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)HIV-2: An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition. It shares serologic reactivity and sequence homology with the simian Lentivirus SIMIAN IMMUNODEFICIENCY VIRUS and infects only T4-lymphocytes expressing the CD4 phenotypic marker.PhenanthrenesNorleucine: An unnatural amino acid that is used experimentally to study protein structure and function. It is structurally similar to METHIONINE, however it does not contain SULFUR.tat Gene Products, Human Immunodeficiency Virus: Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.Bromine Compounds: Inorganic compounds that contain bromine as an integral part of the molecule.Androstanes: The family of steroids from which the androgens are derived.Androstane-3,17-diol: The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.Androsterone: A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.Azasteroids: Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with nitrogen atoms.Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.Testolactone: An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.17-Ketosteroids: Steroids that contain a ketone group at position 17.Hydroxysteroid Dehydrogenases: Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.Castration: Surgical removal or artificial destruction of gonads.

PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. (1/315)

A genetic alteration in the adducin genes is associated with hypertension and up-regulation of the expression of renal Na, K-ATPase in Milan-hypertensive (MHS) rats, in which increased ouabain-like factor (OLF) levels are also observed. PST 2238, a new antihypertensive compound that antagonizes the pressor effect of ouabain in vivo and normalizes ouabain-dependent up-regulation of the renal Na-K pump, was evaluated for its ability to lower blood pressure and regulate renal Na,K-ATPase activity in MHS genetic hypertension. In this study, we show that PST 2238, given orally at very low doses (1 and 10 microg/kg for 5-6 weeks), reduced the development of hypertension in MHS rats and normalized the increased renal Na,K-ATPase activity and mRNA levels, whereas it did not affect either blood pressure or Na,K-ATPase in Milan-normotensive (MNS) rats. In addition, a similar antihypertensive effect was observed in adult MHS rats after a short-term treatment. In cultured rat renal cells with increased Na-K pump activity at Vmax due to overexpression of the hypertensive variant of adducin, 5 days of incubation with PST 2238 (10(-10-)-10(-9) M) lowered the pump rate to the level of normal wild-type cells, which in turn were not affected by the drug. In conclusion, PST 2238 is a very potent compound that in MHS rats reduces blood pressure and normalizes Na-K pump alterations caused by a genetic alteration of the cytoskeletal adducin. Because adducin gene mutations have been associated with human essential hypertension, it is suggested that PST 2238 may display greater antihypertensive activity in those patients carrying such a genetic alteration.  (+info)

Effects of an intubating dose of succinylcholine and rocuronium on the larynx and diaphragm: an electromyographic study in humans. (2/315)

BACKGROUND: Paralysis of the vocal cords is one objective of using relaxants to facilitate tracheal intubation. This study compares the neuromuscular blocking effect of succinylcholine and rocuronium on the larynx, the diaphragm, and the adductor pollicis muscle. METHODS: Electromyographic response was used to compare the neuromuscular blocking effect of succinylcholine and rocuronium on the laryngeal adductor muscles, the diaphragm, and the adductor pollicis muscle. Sixteen patients undergoing elective surgery were anesthetized with propofol and fentanyl, and their tracheas were intubated without neuromuscular blocking agents. The recurrent laryngeal and phrenic nerves were stimulated at the neck. The electromyographic response was recorded from electrodes placed on the endotracheal tube and intercostally before and after administration of 1 mg/kg succinylcholine or 0.6 mg/kg rocuronium. RESULTS: The maximum effect was greater at the adductor pollicis (100 and 99%) than at the larynx (96 and 97%) and the diaphragm (94 and 96%) after administration of succinylcholine and rocuronium, respectively (P < or = 0.05). Onset time was not different between the larynx (58+/-10 s), the diaphragm (57+/-8 s), and the adductor pollicis (54+/-13 s), after succinylcholine (all mean +/- SD). After rocuronium, onset time was 124+/-39 s at the larynx, 130+/-44 s at the diaphragm, and 115+/-21 s at the adductor pollicis. After succinylcholine administration, time to 90% recovery was 8.3+/-3.2, 7.2+/-3.5, and 9.1+/-3.0 min at the larynx, the diaphragm, and the adductor pollicis, respectively. Time to 90% recovery after rocuronium administration was 34.9+/-7.6, 30.4+/-4.2, and 49.1+/-11.4 min at the larynx, the diaphragm, and the adductor pollicis, respectively. CONCLUSION: Neuromuscular blocking effect of muscle relaxants on the larynx can be measured noninvasively by electromyography. Although the larynx appears to be resistant to muscle relaxants, we could not demonstrate that its onset time differed from that of peripheral muscles.  (+info)

sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial na+ channels. (3/315)

The early phase of the stimulatory effect of aldosterone on sodium reabsorption in renal epithelia is thought to involve activation of apical sodium channels. However, the genes initiating this effect are unknown. We used a combination of polymerase chain reaction-based subtractive hybridization and differential display techniques to identify aldosterone-regulated immediate early genes in renal mineralocorticoid target cells. We report here that aldosterone rapidly increases mRNA levels of a putative Ser/Thr kinase, sgk (or serum- and glucocorticoid-regulated kinase), in its native target cells, i.e. in cortical collecting duct cells. The effect occurs within 30 min of the addition of aldosterone, is mediated through mineralocorticoid receptors, and does not require de novo protein synthesis. The full-length sequences of rabbit and mouse sgk cDNAs were determined. Both cDNAs show significant homology to rat and human sgk (88-94% at the nucleotide level, and 96-99% at the amino acid level). Coexpression of the mouse sgk in Xenopus oocytes with the three subunits of the epithelial Na+ channel results in a significantly enhanced Na+ current. These results suggest that sgk is an immediate early aldosterone-induced gene, and this protein kinase plays an important role in the early phase of aldosterone-stimulated Na+ transport.  (+info)

Augmentation of the rocuronium-induced neuromuscular block by the acutely administered phenytoin. (4/315)

BACKGROUND: The effects of an acute administration of phenytoin on the magnitude of the rocuronium-induced neuromuscular block were evaluated. METHODS: Twenty patients (classified as American Society of Anesthesiologists physical status I or II) scheduled for craniotomy were studied: 15 received phenytoin during operation (10 mg/kg), and the others served as controls. Anesthesia was induced with thiopental and fentanyl and maintained with nitrous oxide (65%) in oxygen and end-tidal isoflurane (1%). The ulnar nerve was stimulated supramaximally and the evoked electromyography was recorded using a neuromuscular transmission monitor. Continuous infusion of rocuronium maintained the neuromuscular block with first twitch (T1) between 10 and 15% for 45 min before the start of an infusion of either phenytoin or NaCl 0.9%. Twitch recordings continued for 60 min thereafter. Arterial blood samples were collected at the predefined time points (four measurements before and four after the start of the infusion) to determine the concentrations of phenytoin and rocuronium and the percentage of rocuronium bound to plasma proteins. RESULTS: The first twitch produced by an infusion of rocuronium remained constant during the 15 min before and the 60 min after the start of the saline infusion. After the phenytoin infusion, the twitch decreased progressively, but the plasma concentrations and the protein-bound fraction of rocuronium did not change. CONCLUSION: Phenytoin acutely augments the neuromuscular block produced by rocuronium without altering its plasma concentration or its binding to plasma proteins.  (+info)

Rapid tracheal intubation with rocuronium: a probability approach to determining dose. (5/315)

BACKGROUND: Rapid tracheal intubation with rocuronium has not been studied using a probability-based approach. The authors aimed to predict doses of rocuronium giving 90% and 95% probability of in intubation within 60 s and to estimate their durations of action. METHODS: After premedication with midazolam, 2 mg, anesthesia was induced in 80 subjects with fentanyl, 2 microg/kg, followed 3 min later by propofol, 2 mg/kg. Patients received randomly rocuronium, 0.0, 0.4, 0.8, or 1.2 mg/kg (n = 20/ dose). Laryngoscopy began 40 s later, aiming for intubation at 60 s, and conditions were graded perfect, acceptable, or unacceptable, with the first two conditions being successful intubation. Anesthesia was maintained with isoflurane 0.5-1.0% (end-tidal) and fentanyL Duration of action was time until reappearance of the first tactile train-of-four response. The dose versus fraction of patients with successful intubation was analyzed by logistic regression. Doses giving 90% and 95% (D90 and D95) probability of successful intubation were calculated. RESULTS: intubation was successful in 7, 11, 18, and 19 patients in the 0.0, 0.4, 0.8, and 1.2 mg/kg groups, respectively. The D90 and D95 doses (95% confidence limits in parentheses) were 0.83 (0.59-1.03) and 1.04 (0.76-1.36) mg/kg, respectively. Estimated time until first tactile train-of-four response after D90 and D95 doses was 32 and 46 min, respectively. CONCLUSIONS: After induction with fentanyl and propofol, rocuronium, 1.04 mg/kg gives 95% probability of successful intubation at 60 s.  (+info)

Intramuscular rocuronium in infants and children: a multicenter study to evaluate tracheal intubating conditions, onset, and duration of action. (6/315)

BACKGROUND: This multicenter, assessor-blinded, randomized study was done to confirm and extend a pilot study showing that intramuscular rocuronium can provide adequate tracheal intubating conditions in infants (2.5 min) and children (3 min) during halothane anesthesia. METHODS: Thirty-eight infants (age range, 3-12 months) and 38 children (age range, 1 to 5 yr) classified as American Society of Anesthesiologists physical status 1 and 2 were evaluated at four investigational sites. Anesthesia was maintained with halothane and oxygen (1% end-tidal concentration if <2.5 yr; 0.80% end-tidal concentration if >2.5 yr) for 5 min. One half of the patients received 0.45 mg/kg intravenous rocuronium. The others received 1 mg/kg (infants) or 1.8 mg/kg (children) of intramuscular rocuronium into the deltoid muscle. Intubating conditions and mechanomyographic responses to ulnar nerve stimulation were assessed. RESULTS: The conditions for tracheal intubation at 2.5 and 3 min in infants and children, respectively, were inadequate in a high percentage of patients in the intramuscular group. Nine of 16 infants and 10 of 17 children had adequate or better intubating conditions at 3.5 and 4 min, respectively, after intramuscular rocuronium. Better-than-adequate intubating conditions were achieved in 14 of 15 infants and 16 of 17 children given intravenous rocuronium. Intramuscular rocuronium provided > or =98% blockade in 7.4+/-3.4 min (in infants) and 8+/-6.3 min (in children). Twenty-five percent recovery occurred in 79+/-26 min (in infants) and in 86+/-22 min (in children). CONCLUSIONS: Intramuscular rocuronium, in the doses and conditions tested, does not consistently provide satisfactory tracheal intubating conditions in infants and children and is not an adequate alternative to intramuscular succinylcholine when rapid intubation is necessary.  (+info)

Effects of priming with pancuronium or rocuronium on intubation with rocuronium in children. (7/315)

Rocuronium is a non-depolarizing neuromuscular blocking agent which has a rapid onset and intermediate duration of action. The goal of this study was to compare the neuromuscular blocking actions of rocuronium with and without a priming dose of pancuronium or rocuronium in children. Thirty patients were randomly allocated into 3 groups. Ten patients received a single dose of 0.6 mg/kg rocuronium (Group I). The others received either 0.015 mg/kg pancuronium (Group II) or 0.06 mg/kg rocuronium (Group III) 3 minutes before an intubating dose of 0.54 mg/kg rocuronium was given. Neuromuscular blockade was measured via accelerographic response to single stimulations (1 Hz) of the ulnar nerve until maximal twitch depression was reached followed by train-of-four (TOF) stimuli (2 Hz) at 15 second intervals for the remainder of recovery. Groups were compared with regard to onset time, duration and recovery indices. The onset time and duration of block did not differ significantly between groups. However, the time to recovery in group II (24.5 +/- 9.9 min) was significantly prolonged compared to that in group I (12.7 +/- 3.1 min) or group III (12.7 +/- 3.9 min). We concluded that the use of rocuronium with a preceding dose of either pancuronium or rocuronium provided no advantage for intubation in children.  (+info)

Spontaneous or neostigmine-induced recovery after maintenance of neuromuscular block with Org 9487 (rapacuronium) or rocuronium following an initial dose of Org 9487. (8/315)

We have examined spontaneous and neostigmine-induced recovery after an initial dose of Org 9487 1.5 mg kg-1 followed by three repeat doses of Org 9487, a 30-min infusion of Org 9487 or two incremental doses of rocuronium. Mean clinical duration after incremental doses of Org 9487 0.5 mg kg-1 increased from 12.3 (SD 3.4) min to 14.0 (4.0) and 15.9 (5.9) min (P < 0.01), and after rocuronium from 14.4 (5.2) min to 19.2 (5.9) min (P < 0.01). Times for spontaneous recovery from a T1 of 25% to a TOF ratio of 0.8 after the last bolus dose of Org 9487 and after a 30-min infusion were 72.4 (16.5) and 66.1 (26.9) min compared with 36.7 (15.8) min in the group receiving reocuronium. These times were significantly reduced to 9.9 (4.5), 8.6 (6.1) and 5.7 (2.5) min, respectively, after neostigmine administration at a T1 of 25% (P < 0.05). We conclude that administration of Org 9487 by repeat bolus doses or infusion was associated with slow spontaneous recovery but neostigmine administration resulted in adequate recovery in less than 10 min.  (+info)

It was designed to be a weaker antagonist at the neuromuscular junction than pancuronium; hence its monoquaternary structure and its having an allyl group and a pyrrolidine group attached to the D ring quaternary nitrogen atom. Rocuronium has a rapid onset and intermediate duration of action.[2] There is considered to be a risk of allergic reaction to the drug in some patients (particularly those with asthma), but a similar incidence of allergic reactions has been observed by using other members of the same drug class (non-depolarizing neuromuscular blocking drugs).[3] The γ-cyclodextrin derivative sugammadex (trade name Bridion) has been recently introduced as a novel agent to reverse the action of rocuronium.[4] Sugammadex has been in use since 2009 in many European countries; however, it was turned down for approval twice by the US FDA due to concerns over allergic reactions and bleeding,[5] but finally approved the medication for use during surgical procedures in the United States on ...
ZEMURON (Rocuronium bromide) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
It has been reported that co-administration of ephedrine reduced the onset time of neuromuscular block of rocuronium (1-3). It also provided an improved condition for the rapid tracheal intubation (2,4). This beneficial effect was attributed to the increased cardiac output and tissue perfusion to muscle, and therefore, a more rapid delivery of rocuronium to the neuromuscular junction was achieved (4-5). If so, any drugs which decrease cardiac output consequently can prolong the onset time of rocuronium.. Remifentanil is the first ultra-short acting opioid with a rapid onset. During the total intravenous anesthesia (TIVA) with propofol and remifentanil, prior administration of remifentanil could reduce the propofol infusion pain without other significant complications (6). However, remifentanil can decrease the arterial pressure and heart rate (7-8), so that it is likely to decrease the onset time of rocuronium for the opposite principle that ephedrine increases it.. The investigators therefore ...
Compounds useful as antihypertensive agents, or antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and
The Bispectral Index (BIS) monitor is used in many operating rooms to provide information to the anesthesiologist about a patients level of consciousness. The Composite Variability Index (CVI) is a new index that may provide the anesthesiologist with more information about the condition of the patient. The CVI is a measure of the combined variability in BIS (bispectral index) and frontal electromyography (EMG) activity that may be useful in assessing the nociception/anti-nociception balance for patients under general anesthesia.The purpose of this study is to determine if a commonly used anesthetic drug (rocuronium) affects the CVI measurement differently with different doses. Rocuronium is a neuromuscular blocking agent (NMBA) routinely used during surgery. It is expected that the group given the highest dose of rocuronium will have diminished CVI values.. This study will randomize patients to one of four doses of rocuronium: no rocuronium, 0.2, 0.4, and 0.6 milligrams per kilo of body weight; ...
The USFDA approved Bridion (sugammadex) injection to reverse the effects of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide, which are used during certain types of surgery in adults.
Rocuronium is an intravenous medication that helps to relax patients during general anesthesia, and it helps to facilitate breathing tube insertion.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
INTRODUCTION. Anaphylaxis during anesthesia is a rare event that may occur in up to 1:20,000 cases and approximately 60% to 70% of these cases are secondary to the use of muscle relaxants, particularly succinylcholine and rocuronium1-3. The standard treatment requires immediate discontinuation of the drug, whenever possible, and the use of agents that improve cardiac performance and hemodynamic profile1.. Sugammadex was introduced into medical practice in order to antagonize the clinical action of rocuronium via encapsulation of this muscle relaxant, and this mechanism of action may contribute positively for the treatment of anaphylaxis induced by this neuromuscular blocker4.. The aim of this report is to describe the treatment of a case of rocuronium-induced anaphylaxis with inadequate response to traditional therapy and the case resolution after using sugammadex.. CASE REPORT. A female patient, 62 years old, 72 kg, was referred to the surgical center for treatment of epidural hematoma ...
Sugammadex, a synthetic cyclodextrin sodium salt, was heralded and initially marketed as the first selective relaxant binding agent (SRBA) designed to reverse rocuronium [1]. This chemically modified cyclodextrin basically swallowed rocuronium removing it from the effector site, which was a "paradigm shift" from the then current methodology [2]. Following the launch of rocuronium and the rapidly spreading practice of intubation on rocuronium in rapid sequence instead of succinylcholine, a need to reverse muscle relaxation in case of intubation failure emerged. Moreover, the well-known undesirables side effects of cholinesterase inhibitors needing blunting by coadministration of muscarinic antagonists enlarged the odds of experiencing unwanted extra drug effects [3]. Further studies supported the use of sugammadex to reverse a life-threatening situation defined as "cannot intubate, cannot ventilate" [4]. It was a genuine revolutionary approach [5].Thus sugammadex appeared as a rescue drug. It was ...
The pharmacokinetics of 6 new neuromuscular blocking drugs are described. These are the aminosteroids pipecuronium bromide, rocuronium bromide and rapacuronium bromide (ORG-9487) and the benzylisoquinolinium diesters doxacurium chloride, mivacurium chloride and cisatracurium besilate. In healthy individuals, these drugs all have similar volumes of distribution. Their pharmacokinetics are influenced little by age or anaesthetic technique, but renal and hepatic disease may significantly alter their distribution and elimination. Pipecuronium resembles pancuronium in its pharmacokinetic and neuromuscular blocking profile, but is devoid of cardiovascular effects. It has a low clearance (0.16 L/h/kg) and long elimination half-life (120 minutes). It is largely eliminated through the kidney. Rocuronium has a similar pharmacokinetic profile to vecuronium but its onset of action is more rapid and duration of action slightly shorter. Its clearance (0.27 L/h/kg) is intermediate between those of pipecuronium and
When a patient has a contraindication to succinylcholine, rocuronium bromide is the paralytic agent of choice. At a dose of 1.0 - 1.2 mg/kg IV, rocuronium achieves intubating conditions similar to those of succinylcholine and lasts 50 minutes. ...
As the year is coming to a close, in the long line of killing labs, here is a newcomer! Meet Mylan, the supplier of a death drug, rocuronium bromide, for the Alabama death business. 14 executions are scheduled in the USA between now and the end of the year, thanks to compounding pharmacists who have knowingly supplied department of corrections with whatever drugs were asked for in violation of medical ethics. Continue reading. ...
This study assessed the efficacy of rostafuroxin in patients with stable uncomplicated essential hypertension. The primary endpoint was the change in office
cyclobarbital: was heading 1977-94 (see under BARBITURATES 1977-90); CYCLOBARBITONE, HEXEMAL, & TETRAHYDROPHENOBARBITAL were see CYCLOBARBITAL 1977-94; use BARBITURATES to search CYCLOBARBITAL 1977-94; short to intermediate duration barbiturate used as hypnotic and sedative
INTRODUCTION. Sugammadex is a chemically modified gamma-cyclodextrin that acts as a selective antagonist of neuromuscular blockade induced by rocuronium and vecuronium 1. Rocuronium has proved to be a reasonable alternative to provide a rapid sequence induction without the occurrence of some events observed in patients when using succinylcholine, such as hyperkalemia, masseter muscle rigidity, reported onset of malignant hyperthermia (in some cases after its usage). Sugammadex has been used to provide the reversal of various doses of rocuronium (0.6, 1.0, and 1.2 mg.kg-1) 2.. The aim of this report is to describe a case in which sugammadex was used to reverse muscle relaxation immediately after rocuronium induction in an elderly patient, following unsuccessful tracheal intubation maneuvers.. CASE REPORT. RBQC, aged 88 years and 9 months, 34 kg, female, presented with femoral neck fracture 8 hours before the procedure, ASA II, skinny, with a history of lumbar spine ankylosis and no additional ...
Abstract BACKGROUND: Traditionally, reversal of nondepolarizing neuromuscular blocking agents was achieved using acetylcholinesterase inhibitors, but these are unable to adequately..
Intravenous magnesium re-establishes neuromuscular block after spontaneous recovery from an intubating dose of rocuronium: a randomised controlled ...
Pharmacoeconomics and Pharmacodynamic Interactions of Rocuronium and Pancuronium. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Dosage of sugammadex according to the calculated lean body mass in obese female patients: time to reverse moderate neuromuscular blockade induced by rocuronium
The purpose of this study was to compare the pattern of recovery from vecuronium 0.07 mg.kg-1 induced neuromuscular blockade using post-tetanic burst count (PTBC)-(three short tetanic bursts of 0.2 msec duration every 20 msec given every second follo
Schering-Plough says that regulators in the USA will give a priority review to sugammadex, its new drug which is designed to reverse the effects of certain muscle relaxants used in general anaesthesia during surgery. - News - PharmaTimes
Our hospital is finally getting Sugammadex. I am so thrilled that we have something else to use to quickly reverse patients other than neostigmine. I figure it it time to write a post about the medication to give you a quick summary of what the drug is, how it works, and the side effects etc.…
Merck & Co has been dealt a blow after US authorities knocked back its anaesthesia reversal drug sugammadex for the second time. - News - PharmaTimes
Lidocaine HCL 2% 1:100,000 (Cook Waite), these versatile widely applicable injection delivers local anesthesia of intermediate duration.
Most of which are fairly rare and I (fortunately) dont need to intubate very frequently. But when that relative zebra is really sick, I have enough on my mind and I dont want to have to think to hard about which drugs may be dangerous. Note that in MG, you can use succinylcholine but have to use more; you can use a lower dose of rocuronium but a normal dose will just paralyze them longer, which is much safer than me having to remember this whole paragraph and do math when the chips are about to hit the fan ...
Most of which are fairly rare and I (fortunately) dont need to intubate very frequently. But when that relative zebra is really sick, I have enough on my mind and I dont want to have to think to hard about which drugs may be dangerous. Note that in MG, you can use succinylcholine but have to use more; you can use a lower dose of rocuronium but a normal dose will just paralyze them longer, which is much safer than me having to remember this whole paragraph and do math when the chips are about to hit the fan ...
TY - JOUR. T1 - Evaluation of the mydriatic effects of topical administration of rocuronium bromide in Hispaniolan Amazon parrots (Amazona ventralis). AU - Petritz, Olivia A.. AU - Guzman, David. AU - Gustavsen, Kate. AU - Wiggans, K. Tomo. AU - Kass, Philip H. AU - Houck, Emma. AU - Murphy, Christopher J. AU - Paul-Murphy, Joanne R. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Objective To determine the mydriatic effects of topical rocuronium bromide administration in Hispaniolan Amazon parrots (Amazona ventralis) and to identify any adverse effects associated with treatment. DESIGN Randomized crossover study. ANIMALS 8 healthy adult Hispaniolan Amazon parrots. PROCEDURES Rocuronium bromide (20 μL/eye; 10 mg/mL) or saline (20 μL/eye; 0.9% NaCl) solution was administered in both eyes of each bird with a 26-day washout period. The birds were manually restrained in lateral recumbency with the apex of the cornea positioned upward for 2 minutes following administration in each eye. Infrared pupillometry and ...
en] BACKGROUND AND OBJECTIVE: Residual muscle paralysis remains a concern for anaesthesiologists. This study investigated the recovery from neuromuscular block (NMB) after an intubation dose of cisatracurium (C) or rocuronium (R) in 32 patients undergoing lumbar disc surgery. METHODS: Anaesthesia was induced with propofol and sufentanil, and maintained with sevoflurane in nitrous oxide/oxygen. Patients were randomised to receive twice the ED95 of either cisatracurium (GC) or rocuronium (GR) before tracheal intubation. After placement in prone position, neuromuscular transmission was monitored at the wrist by accelerometry. NMB was antagonised when the TOF ratio (TOFR) was , 0.75 at muscle closure. The time from muscle relaxant to muscle closure, and to TOFR of 0.25 and of 0.50 were recorded. Data were analysed using Students t-tests, chi-squared tests and two-way mixed-designed ANOVAs. The prediction probability (Pk) of the times from muscle relaxant to muscle closure, and to TOFR of 0.25 for ...
KENILWORTH, N.J., Mar 13, 2015 (BUSINESS WIRE) -- Merck MRK, +0.55% known as MSD outside the United States and Canada, said it was informed today that the U.S. Food and Drug Administration (FDA) has cancelled the meeting of the Anesthetic and Analgesic Drug Products Advisory Committee scheduled for March 18, 2015. The committee had planned to discuss the resubmission of the New Drug Application (NDA) for sugammadex injection, Mercks investigational medicine for the reversal of neuromuscular blockade induced by rocuronium or vecuronium. The FDA has advised Merck that it plans to conduct additional site inspections related to a hypersensitivity study (Protocol 101). The Agency has indicated it plans to conduct these additional inspections prior to an Advisory Committee meeting and completion of their review. Due to the timing of the additional inspections, Merck expects to receive a Complete Response Letter at the time of the Prescription Drug User Fee Act action date for the NDA for sugammadex ...
All 29 subjects completed the study. One subject in part 1 discontinued his participation after the second treatment period due to an unrelated cardiac event. Other adverse events included taste perversion (one event lasting 2 min, another for 43 min); dry mouth; paresthesia (one event lasting 7 days); and muscular contractions for a 12-h period (in part 2 of the study). When administered as a single intravenous bolus at doses up to 8.9 mg/kg, Org 25969 was well tolerated. Because of this studys small sample size and isolated out-of-normal-range electrocardiogram values, the safety of this drug must be confirmed in other investigations. In two subjects given 8 mg/kg Org 25969 during a profound neuromuscular blockade, the train-of-four ratio returned to 0.9 approximately 1 min after administration of the reversal agent. During a profound neuromuscular block, the speed of recovery with Org 25969 compared to administration of neostigmine. Further investigation may help reveal variability of ...
Adductor Pollicis Muscle contributes to pain at the base of the thumb extending into the thumb. Gripping objects between index finger and thumb is painful.
As the year is coming to a close, in the long line of killing labs, here is a newcomer! Meet Mylan, the supplier of a death drug, rocuronium bromide, for the Alabama death business. 14 executions are scheduled in the USA between now and the end of the year, thanks to compounding pharmacists who have knowingly supplied department of corrections with whatever drugs were asked for in violation of medical ethics. Continue reading. ...
A piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent (NEUROMUSCULAR NONDEPOLARIZING AGENTS). It is used as a muscle relaxant during ANESTHESIA and surgical procedures ...
2% Lidocaine HCl injection with 1:100,000 epinephrine bitartrate. A versatile local anesthetic of intermediate duration. Delivers pulpal anesthesia of approximately 60 minutes and soft tissue anesthetic of approximately 3-5 hours.) Lidocaine is part of the complete line of Cook-Waite products the brand dental professionals have relied on for more than 60 years. Each box contains 50 x 1.7mL cartridges.. MSDS. Product Brochure. ...
Succinylcholine *You should not use succinylcholine in a burn patient who likely has hyperkalemia from myonecrosis.* Rocuronium vs. Succinylcholine
Patient information for CISATRACURIUM 2 MG/ML SOLUTION FOR INJECTION OR INFUSION Including dosage instructions and possible side effects.
Introduction: Rapid Sequence Induction of anaesthesia (RSI) is the recommended method to facilitate emergency tracheal intubation in trauma patients. In emergency situations, a simple and standardised RSI protocol may improve the safety and effectiveness of the procedure. A crucial component of developing a standardised protocol is the selection of induction agents. The aim of this study is to compare the safety and effectiveness of a traditional RSI protocol using etomidate and suxamethonium with a modified RSI protocol using fentanyl, ketamine and rocuronium. Methods: We performed a comparative cohort study of major trauma patients undergoing pre-hospital RSI by a physician-led Helicopter Emergency Medical Service. Group 1 underwent RSI using etomidate and suxamethonium and Group 2 underwent RSI using fentanyl, ketamine and rocuronium. Apart from the induction agents, the RSI protocol was identical in both groups. Outcomes measured included laryngoscopy view, intubation success, haemodynamic ...
Standard rapid sequence induction (RSI) techniques can be used but may cause loss of the airway in a patient whose airway anatomy is altered by edema. Severe laryngeal edema may occur so rapidly durin... more
Other articles where Adductor pollicis muscle is discussed: adductor muscle: …for this function include the adductor pollicis, which draws in and opposes the thumb, and the adductor hallucis, which acts on the great toe.
Smarter Decisions, Better Care. Food and Drug Administration today approved Bridion sugammadex injection to reverse the effects of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide, which are used during certain types of surgery in adu"... Lidocaine elimination: effects of metoprolol and of propranolol. What Cholesterol Levels Mean. The Stages of Lung Cancer. If this product alone cannot completely numb the area being treated, it may be used to numb the area before a lidocaine injection is given to provide enough pain relief for certain procedures e. Medical treatments for wrinkles include antioxidants, moisturizers, alpha-hydroxy acids, and vitamin A acid.. Citing articles xream CrossRef. Discover common skin conditions like psoriasis, rashes, and more in the collection of medical photos. Compounded lidocaine-containing topical analgesics combinations have been widely used to treat pain derived from both musculo-skeletal and neuropathic conditions. It may replace ...
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A 7-month-old, 7-kg infant received 6 mg cisatracurium intravenously after induction of anesthesia with nitrous oxide and halothane. There was no change in heart rate, noninvasive blood pressure obtained with the cuff on the upper arm, or skin color, but when the surgery was concluded, neuromuscular block persisted to the extent that no posttetanic count could be elicited. The infant received midazolam and mechanical ventilation in the recovery room. One hundred minutes after the dose of 0.86 mg/kg cisatracurium, a very slight response of the adductor pollicis to stimulation of the ulnar nerve with 2 Hz, a train-of-four (TOF) every 60 s was documented by the Datex neuromuscular transmission monitor electromyogram in the uncalibrated mode. One hundred and ten minutes after the bolus of cisatracurium, four responses to the TOF were recorded. At this time, the patients diaphragm, fingers, and toes were moving spontaneously. Propofol was administered by infusion to produce immobility. During the ...
Objective: With an iicidence of 24-80%, injection pain of propofol is its most well known and most frequent side effect. Rocuronium, a steroidal nomlepolarizing muscle relaxant, is also among agents which can cause injection pain. The goal of our study was to compare the relevance of cannula diameter, location of vascular access and gender with pain perception of intravenous injection of propofol and rocuronium. Material and Method: A total of 637 patients in ASA 1-11 groups between the ages of 16-80 whose operations were planned with general anesthesia between June 1st 2012 and December 31st 2012 were included in this study. Cases were divided into four groups according to site of cannulation and diameter of the cannula as: Group 1 (back of the hand 20 gauge), Group 2 (antecubital zone 20 gauge), Group 3 (back of the hand 22 gauge) and Group 4 (antecubital zone 22 gauge). Residts: There was no statistically significant difference between patients demographic findings, and initial hemodynamic ...
Thesis, English, Comparison of Kinemyography with Electromyography Neuromuscular Monitoring in Pediatric Patients Receiving Cisatracurium or Rocuronium during General Anesthesia for Abdel Aziz Mohammed Abdel Rahmn
The purpose of this study was to demonstrate in adult patients faster recovery from a neuromuscular block induced by either rocuronium or vecuronium after
Inhaled Anaesthetic Agents IV Induction Agents Ketamine Midazolam Neuromuscular Blockers - General Propofol Rocuronium Sedation - Principles Suxamethonium Thiopentone
Y NTEMLER: al mam za 28 erkek Wistar Albino s an dahil edildi. S anlar 4 gruba ayr ld . Sham grubuna anestezi uygulamas d nda bir giri im uygulanmad . Kontrol grubuna 3 saat iskemi ve 24 saat reperf zyon uyguland . Sgdks4 grubu ve Sgdks 16 grubu, intraven z olarak s ras yla 4 mg / kg ve 16 mg / kg Sugammadeks ald ve ard ndan reperf zyon uyguland . Histopatolojik inceleme ve serum kreatin kinaz (CK), laktat dehidrojenaz (LDH), serum ve doku malondialdehid (MDA) ve s peroksit dismutaz (SOD) analizleri yap ld ...
Professional guide for Cisatracurium Besylate. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
[65 Pages Report] Check for Discount on Cisatracurium besilate Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
4. Describe the metabolism of each of the neuromuscular blockers; what are the relative percentages excreted by the liver and the kidney ...
TY - JOUR. T1 - Effects of pretreatment with cisatracurium, rocuronium, and d-tubocurarine on succinylcholine-induced fasciculations and myalgia. T2 - A comparison with placebo. AU - Joshi, Girish P.. AU - Hailey, Amaha. AU - Cross, Steven. AU - Thompson-Bell, Gwendell. AU - Whitten, Charles C.. PY - 1999/12. Y1 - 1999/12. N2 - Study Objective: To evaluate the efficacy of cisatracurium, rocuronium, and d-tubocurarine in preventing succinylcholine-induced fasciculations and postoperative myalgia in patients undergoing ambulatory surgery. Design: Randomized, prospective, placebo-controlled trialSetting: Teaching hospital. Subjects: 80 ASA physical status I and II patients scheduled for elective ambulatory surgery with general anesthesia.Intervention: A standardized balanced anesthetic technique was used for all patients. Measurements and Main Results: Patients were randomized to receive cisatracurium 0.01 mg/kg, rocuronium 0.06 mg/kg, d-tubocurarine 0.05 mg/kg, or saline, 3 minutes prior to ...
Looking for online definition of phase-II neuromuscular block in the Medical Dictionary? phase-II neuromuscular block explanation free. What is phase-II neuromuscular block? Meaning of phase-II neuromuscular block medical term. What does phase-II neuromuscular block mean?
en] We studied the effects of intravenous ephedrine on the onset time and the intubating conditions 2 min after a bolus dose of cisatracurium (0.15 mg kg-1). Thirty patients anaesthetized with sufentanil and propofol were randomly divided in 2 groups to receive either ephedrine (70 micrograms.kg-1) or saline, 5 s before propofol. Cisatracurium was administered after loss of consciousness. Neuromuscular block was assessed at the adductor pollicis using accelography. Tracheal intubation was performed 2 min after cisatracurium injection and rated as excellent, good, poor or bad. At intubation, neuromuscular block (% height of control T1) was greater in patients receiving ephedrine (36.1 +/- 25.8% vs 57.9 +/- 25.1%) (mean +/- SD). The frequency of excellent intubating conditions was higher after ephedrine (86.6%) than after saline (40.0%). The onset time of cisatracurium was shorter after ephedrine (167 +/- 64.8 s vs 234.9 +/- 63.1 s). Thus, a low dose of ephedrine given before induction of ...
Ketamine versus propofol for strabismus surgery in children Ayse Mizrak1, Ibrahim Erbagci2, Tulin Arici1, Ibrahim Ozcan1, Gurkan Tatar2, Unsal Oner11Anesthesiology and Reanimation, Gaziantep University School of Medicine, Gaziantep, Turkey; 2The Department of Ophthalmology, Gaziantep University School of Medicine, Gaziantep, TurkeyPurpose: To compare the effects of intravenous infusion of ketamine and propofol anesthesia in children undergoing strabismus surgery. Methods: Sixty pediatric patients aged 4â 11 years were enrolled for the study. Patients in Group K were infused ketamine 1â 3 mg/kg/hr (n = 30) and patients in Group P were infused with propofol6â 9 mg/kg/hr (n = 30). After giving fentanyl 1 µg/kg and rocuronium bromide 0.5 mg/kg, patients were intubated.Results: The consumption of anesthetics (P = 0.0001) and antiemetics (P = 0.004), the incidence of Â-oculocardiac reflex (P = 0.02) in Group K were significantly lower than in Group P. The recovery time (P = 0.008), postoperative
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Limitace pro AChEI antagonizační látky Před objevení BRIDIONu (sugammadex) byly antagonizační látky pouze inhibitory acetylcholinesterázy (AChEIs) jako je Syntostigmin (neostigmini bromidum) Mají mnoho limitací: Nepřímý mechanizmus účinku Signifikantní vedlejší účinky Nemožnost antagonizovat hlubokou blokádu Nemožnost získat rychlou a kompletní antagonizaci Možnost rizika prodloužení blokády BEFORE BRIDION, the only reversal agents were anticholinesterase inhibitors, notably neostigmine Despite being used for many years, these are not perfect, having many limitations: They work indirectly, by increasing neurotransmission at cholinergic receptors through reducing the action of the enzyme that normally breaks down acetylcholine This is not specific for nicotinic receptors on the muscle membrane, leading to many unwanted side effects (e.g. cardiovascular - on heart rate, gastrointestinal - nausea and vomiting) This requires co-administration of other drugs to counter
Pris: 650,-. E-bok, 2015. Leveres direkte via nedlastning . Kjøp boken Neuromuscular Function and Disorders av Alan J. McComas (ISBN 9781483163062) hos Adlibris.com. Fri frakt.
To reverse any adverse effects caused by certain bromides used in adult surgery, the U.S. Food and Drug Administration (FDA) recently announced its approval of Bridion (Sugammadex) via intravenous injection from its Silver Spring, Maryland, offices
In advanced airway management, rapid sequence induction (RSI) - also described as rapid sequence intubation or as rapid sequence induction and intubation (RSII) - is a special process for endotracheal intubation that is used where the patient is at a high risk of pulmonary aspiration or impending airway compromise. It differs from other forms of general anesthesia induction in that artificial ventilation is generally not provided from the time the patient stops breathing (when drugs are given) until after intubation has been achieved. This minimizes insufflation of air into the patients stomach, which might otherwise provoke regurgitation. "Classic" RSI involves pre-filling the patients lungs with a high concentration of oxygen gas, followed by applying cricoid pressure, administering rapid-onset sedative or hypnotic and neuromuscular-blocking drugs that induce prompt unconsciousness and paralysis, inserting an endotracheal tube with minimal delay, and then releasing the cricoid pressure. ...
Accurate localisation of the cricoid cartilage is a key step in the successful application of cricoid pressure during rapid sequence induction. Poorly localised pressure is unlikely to confer any protective benefit to our patients and may have deleterious effects on laryngoscopy. We postulated that the use of ultrasound would greatly improve the accuracy of cricoid cartilage localisation prior to the application of cricoid pressure.
General anesthesia is a drug-induced reversible state where neuromuscular blockade (NMB), hypnosis, and analgesia (jointly denoted by depth of anesthesia - DoA) are guaranteed. This thesis concerns mathematical modeling and feedback control of the effect of the muscle relaxants atracurium and rocuronium, the hypnotic propofol, and the analgesic remifentanil. It is motivated by the need to reduce incidences of awareness and overdose-related post-operative complications that occur in standard clinical practice. A major challenge for identification in closed-loop is the poor excitation provided by the feedback signal. This applies to the case of drugs administered in closed-loop. As a result, the standard models for the effect of anesthetics appear to be over-parameterized. This deteriorates the result of system identification and prevents individualized control.. In the first part of the thesis, minimally parameterized models for the single-input single-output NMB and the multiple-input ...
In rodents, neonatal sevoflurane exposure induces neonatal apoptosis in the brain and results in learning deficits. Sugammadex is a new selective neuromuscular blockade (NMB) binding agent that anesthesiologists can use to achieve immediate reversal of an NMB with few side effects. Given its molecular weight of 2178, sugammadex is thought to be unable to pass through the blood brain barrier (BBB). Volatile anesthetics can influence BBB opening and integrity. Therefore, we investigated whether the intraperitoneal administration of sugammadex could exacerbate neuronal damage following neonatal 2% sevoflurane exposure via changes in BBB integrity ...
definition of LAP, what does LAP mean?, meaning of LAP, Laryngeal Adductor Paralysis, LAP stands for Laryngeal Adductor Paralysis
Observing the similar mortality in ACURASYSs control arm (40.7%) with ROSEs (42.8%) with similar severity of ARDS, the huge variance in the use of prone positioning, and the absence of other good reasons, that is a possibility that must be considered.. Also plausible is that continuous neuromuscular blockade doesnt help at all, and ACURASYSs positive findings were due to unmeasurable bias (like care teams noticing which patients were paralyzed). This would be a disappointing but familiar repetition of other practice-changing trials that were contradicted by larger subsequent studies.. Thanks to ROSE, it does seem clear that continuous neuromuscular blockade is not superior to as-needed use in supine ventilated patients with ARDS, and it may cause cardiovascular harm, which is very helpful to know. (Of course, any cardiovascular harm was insufficient to change all-cause mortality, meaning the practice can be considered appropriate on an individualized basis.). Now, it would be good to see ...
From: [email protected](Steven B. Harris) Newsgroups: sci.med Subject: Re: Awareness under anesthesia Date: 12 Feb 1999 08:44:01 GMT In ,[email protected]> "Steven Belknap, M.D." ,[email protected]> writes: >[[ This message was both posted and mailed: see > the "To," "Cc," and "Newsgroups" headers for details. ]] > >Hey, Cecil- > >The British medical journal letter writer raises a very interesting >point. First, the dogma. Neuromuscular blocking agents are given to >reduce muscle tone during surgical anesthesia. This allegedly provides >several advantages: > >1. Prior to the beginning of the surgical procedure, a neuromuscular >blocker is given to relax the muscles of the head and neck, which >simplifies placement of the endotracheal tube and avoids >overstimulation of vagal and other reflexes which can cause hypotension >and arrhythmias. This tube is connected to the ventilator, which >delivers inhalant anesthetics and oxygen and removes carbon dioxide >from ...
Y NTEM ve GERE LER: Bu prospektif ara t rmada Etik Kurul izni ve hasta onam al narak, ASA I-II fizyoloji s n f ndaki, 74 eri kin hasta, randomize olarak 2 mg kg-1 sugammadeks (Grup S) veya 0,04 mg kg-1 neostigmin + 0,5 mg atropin (Grup N) gruplar na dahil edildi. Gruplar n, TOF (d rtl uyar ) 0,9 elde edilme s resi, ameliyat salonu kullan m s resi, anestezi sonras bak m nitesinde (ASB ) izlem s resi, postoperatif solunumla ilgili komplikasyonlar n g r lme s kl , izlem, tetkik ve tedavi maliyetleri (Sa l k Uygulama Tebli i) kar la t r ld ...
The study was designed to compare the electromyographic (EMG) and evoked twitch tension (TT) responses in humans to train-of-four stimulation during neuromuscular blockade induced with a continuous Succinylcholine infusion. Mean values of TT correlated well with EMG (r | 0.97), but several consisten...
HumanSim: Sedation and Airway trains administering anesthesia in austere environments via Rapid Sequence Induction (RSI) and Moderate Sedation. The application couples an advanced physiology engine with an immersive training environment, addressing critical skill proficiencies and cognitive decision making for physicians deployed in the field. Features include ...
A case is reported where progressive muscular weakness and respiratory failure, occurring during and after operation, is thought to have been due to the use of antibiotics, probably streptomycin and neomycin.
Marketed as Suxamethonium, succinylcholine is a depolarizing muscle relaxant, first used in 1951 as a muscle relaxant. It is still used today for rapid ...
Muscle, one end of which is parallel to the middle finger (indeed, attached to the bone structure of that finger), which then streches to the base of th...
Gastric or bowel contents can make their way into the pharynx by either vomiting or regurgitation/ reflux. Vomiting is an active process requiring muscle contraction of the abdominal wall. Therefore vomiting does not occur in adequately anesthetized or paralyzed patients. Regurgitation or reflux on the other hand is passive, requiring a pressure difference between stomach and pharynx as well as impaired lower esophageal sphincter function. Patient positioning, i.e. head-up tilt, can therefore go some way to prevent regurgitation or reflux. Head-down tilt (Trendelenburg position) does not stop reflux of stomach contents, it rather encourages it, but it can prevent aspiration once gastric contents are in the pharynx. Cricoid pressure during rapid sequence induction is applied to replace the function of a lower esophageal sphincter in preventing passive regurgitation.. ...
in British Journal of Anaesthesia (2006), 97(6), 842-847. Background. The spectral entropy of the electroencephalogram has been proposed to monitor the depth of anaesthesia. State Entropy (SE) reflects the level of hypnosis. Response Entropy (RE), computed from ... [more ▼]. Background. The spectral entropy of the electroencephalogram has been proposed to monitor the depth of anaesthesia. State Entropy (SE) reflects the level of hypnosis. Response Entropy (RE), computed from electroencephalogram and facial muscle activity, reflects the response to nociceptive stimulation. We evaluated the effect of rocuronium on Bispectral Index (TM) (BIS) and entropy responses to laryngoscopy. Methods. A total of 25 patients were anaesthetized with propofol using a target-controlled infusion. At steady state, they randomly received 0.6 mg kg(-1) rocuronium (R) or saline (S). After 3 min, a 20 s laryngoscopy was applied. BIS, RE and SE were recorded continuously and averaged over 1 min during baseline, at ...
Background : Critical oxyhaemoglobin desaturation can occur if ventilation is unassisted with the conventional intubation dose of 1.0mgkg-1 succinylcholine. We conducted this study to evaluate the role of low dose succinylcholine in producing acceptable intubating conditions during rapid tracheal intubation in paediatric patients and whether it leads to a lesser duration of apnoea. Patients & Methods: After IRB approval and parental consent, this prospective, randomized, double blind study included 60 patients (age 3-15 yrs). Patients received IV midazolam 0.05 mgkg-1 as premedication. Anaesthesia was induced with fentanyl 2 μgkg-1 and propofol 3 mgkg-1. Patients respiration was then assisted with 1% halothane in 100% oxygen over 1 minute (denitrogenation). Patients were randomized to receive either 1 mgkg-1 or 0.5 mgkg-1 succinylcholine. Tracheal intubation conditions were graded 60s after succinylcholine administration. Patients were left apnoeic after succinylcholine injection till ...
Intraoperative course. I. Anesthetic choice. 1. Do you recommend regional or general anesthesia? Explain your rationale.. 2. Does her diabetes influence your decision? Explain.. 3. Does her obesity influence your decision? Explain.. II. Monitors. 1. Would you monitor this patient differently than you would for a slender diabetic for the same procedure? Why?. 2. Does the presence of right ventricular hypertrophy alter your monitoring? Why or why not?. 3. How does it alter your monitoring?. 4. A colleague recommends a pulmonary artery catheter with continuous oxygen saturation monitoring. Do you agree?. 5. How will you monitor her diabetic status with regional anesthesia?. 6. How will you monitor her diabetic status with general anesthesia?. III. Anesthetic induction and intubation. 1. The patient refuses regional. Will you do a rapid sequence induction? Explain.. 2. What are the hazards of rapid sequence induction in this patient?. 3. Would premedication with ranitidine and metoclopramide ...
OBJECTIVES. The aim of this work was to compare the effects of sevoflurane and desflurane upon the intracranial pressure, cerebral perfusion pressure and haemodynamic variables in normocapneic dogs, maintained under mechanical ventilation.. MATERIALS. Twelve healthy, adult, mongrel dogs were used. The animals were randomly separated into two groups of 06 animals each (GSEVO and GDES). The anesthesia was induced in all animals through intravenous administration of propofol (8 mg/kg). The dogs were intubated and received rocuronium (0.6 mg/kg), intravenously. The neuromuscular blockade was maintained during all the experimental period through continuous infusion of rocuronium (0.6 mg/kg/h). Mechanical ventilation was used to maintain the capnometry constant at 35 mmHg. The body temperature was also maintained within the physiological rate for the species.. The maintenance of anesthesia was done with sevoflurane (1.5 MAC) in GSEVO and desflurane (1.5 MAC) in GDES. The administration of the volatile ...
Binding agents with differential activity can be provided, whereby certain activities of a first part of the binding agent are reduced or prevented until binding to a target occurs. This is useful if the binding agent is intended to bind both an effector cell and a target to be destroyed, because the effector cell can be protected from significant cell damage that might otherwise occur (e.g. due to premature activation of complement and/or ADCC). Such binding agents are useful in the treatment of cancer, for example.
Am major events in infants and children with any spectrum ranging from vague digestive problems and aches and pains. The research model selected must include consideration of motion. Bjog, matsui h, iitsuka y, yamazawa k, et al rectal thiopental or methohexital etomidate ketamine fentanyl rocuronium vecuronium pancuronium dose dependent and greatly increased the leukocyte count and esr levels. The cobb method see fig. Mild oscillations usually become evident at a time.
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succinylcholine chloride (anhydrous) 71-27-2 NMR spectrum, succinylcholine chloride (anhydrous) H-NMR spectral analysis, succinylcholine chloride (anhydrous) C-NMR spectral analysis ect.
Suxamethonium information about active ingredients, pharmaceutical forms and doses by Shanghai Xudong Haipu Pharmaceutical, Suxamethonium indications, usages and related health products lists
Hi every one, I have a question that has been puzzling me for some time. I have asked my Doctor and the Neurologists and they have not really seen any study or information to clarify my question, so I ...
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Some 40-60% of patients with coma producing brain injuries will have intracranial hypertension. The National Emergency Airway Course recommends a pre-treatment dose of Lignocaine (1.5mg/kg) given 3 minutes before induction when intubating head injured patients. Analysing the results of the above search there appears to be little high quality evidence available to show that intravenous lignocaine suppresses the rises in intracranial pressure associated with rapid sequence intubation in head injured patients ...
Results 95 patients (60 male mean [±SD] age 59.2 [±19.1]; 35 female, 55.2 [±28.4]) with suspected severe UGIB were treated in emergency theatres over the 12 month period. 93/95 (98%) had significant UGIB; 82% ASA grade ≥3 and Glasgow Blatchford Scores (GBS) were recorded in 18% of cases; median (range) score 12 (1-19). 64% were classified as theatre urgency 1 (U1; within 60 mins) and 25% U3 (within 180 mins). 64% of those in U1 had a high shock index (SI , 0.9). However, median time from referral to endoscopy was 215 (range 37-1370) minutes. 47% breached the theatre urgency code times; including 59% of those assigned to U1. A consultant gastroenterologist was present in theatre in 86/95 (91%) of cases and 96% of patients received a general anaesthetic with rapid-sequence induction. The UGIB was non-variceal in 55/95 (58%; endoscopic intervention in 63%), variceal in 32/95 (34%), no cause found 8/95 (8%). 70% received a blood transfusion within 24 hrs of admission, mean 2.7(±2.5) units ...
All information about the latest scientific publications of the Clínica Universidad de Navarra. Neuromuscular blockade monitoring. Part 2
Genetic studies of bipolar disorder in patients selected by their. GENETIC STUDIES OF BIPOLAR DISORDER IN PATIENTS SELECTED BY THEIR. McInnis MG, McMahon FJ.. and lamotrigine compared with tricyclic. 25-9. Epub 2012 Jul 24. Anesthesia was induced with propofol 2 mg/kg and rocuronium 0.6 mg/kg and maintained with.Lamictal Dispersable, lamotrigina, tabletas indicadas en el tratamiento de epilepsia en adultos y niños, y trastorno bipolar. GlaxoSmithKline. RX.. la dosis inicial de LAMICTAL ® DISPERSABLE es 25 mg cada día alterno por dos semanas, seguidos de 25 mg una vez al día por dos semanas.LAMICTAL can cause serious rashes requiring hospitalization and. Ibuprohm,. Compare Cialis 20 mg prices from verified online pharmacies or local U.S pharmacies.Topamax 25 Mg Migraine. And lamictal combination and eyesight can you use tampons while using metronidazole interaction between hctz dopamax.Contiene: Lamotrigina 25 mg. Dosis: La que el médico señale. Vía de administración:. Lamictal ...
Treatment of bleeding complications when using oral anticoagulants for prevention of strokes.In this study, the most common side effect from use of Praxbind was headache.Related Information FDA: Office of Hematology and Oncology Products.Idarucizumab, an antibody fragment, was developed to reverse the.Further, the lack of reliable and routinely available laboratory means of monitoring the anticoagulant effect of NOACs compounds the uncertainty regarding the efficacy of any reversal product.Includes: indications, dosage, adverse reactions, pharmacology and more.. The antidote immediately and significantly reversed the anticoagulation activity of rivaroxaban, making this study the second successful test of the antidote with the.In the case of any discrepancy in meaning, the English version is considered official.Please confirm that you would like to log out of Medscape. the two tested reversal agents that. hemostatic agent to reverse the rivaroxaban effects on the.This website has been translated ...
تقدم هذه المقالة طريقة لقياس حجم البطن العمل أثناء استئصال الورم العضلي laproscopic باستخدام الممسك الجراحية، ويتم تطبيق هذه التقنية...
And they know how to handle combative patients. There are wonderful medicines...... succinylcholine chloride........pavulon, that paralzye patients. When paralyzed, patients quit breathing for themselves and my crews have to breath for them manually. With succinylcholine, (sux), the patient is fully concious and aware they cant breathe. Crews using "sux" will normally administer a strong sedative so the patient goes to "La La land".......the patient could care less who is in charge of the breathing! Life is wonderful ...
article{104f1a02-6683-4458-bad2-99d4587fa569, abstract = {Intact pharyngeal function and coordination of breathing and swallowing are essential for airway protection and to avoid respiratory complications. Postoperative pulmonary complications caused by residual effects of neuromuscular-blocking agents occur more frequently in the elderly. Moreover, elderly have altered pharyngeal function which is associated with increased risk of aspiration. The purpose of this study was to evaluate effects of partial neuromuscular block on pharyngeal function, coordination of breathing and swallowing, and airway protection in individuals older than 65 yr.}, author = {Cedborg, Anna I Hårdemark and Sundman, Eva and Bodén, Katarina and Hedström, Hanne Witt and Kuylenstierna, Richard and Ekberg, Olle and Eriksson, Lars I}, issn = {1528-1175}, language = {eng}, number = {2}, pages = {312--325}, publisher = {Lippincott Williams & Wilkins}, series = {Anesthesiology}, title = {Pharyngeal Function and Breathing ...
Extracted from text ... Southern African Journal of Anaesthesia & Analgesia ? March 2006 25 REGISTRAR The relationship between intra-operative entropy of the EEG and non-depolarizing neuromuscular blockade: A descriptive study HW van Rooyen Background Entropy is based on the extent of order in both the cortical EEG and facial EMG (FEMG) signals, measured from the patient's forehead. Order equals regularity of the EEG signal. In an awake patient, the EEG is very irregular and the entropy high. As the level of anesthesia deepens, the EEG becomes more orderly and the entropy reduces.1 The deeper the level of anesthesia, the lower the frequency ..
While the above classification of the muscle relaxants into depolarising/non-depolarising and aminosteroids/benzylisoquinoliniums is important knowledge that should be known by all who use these drugs, what really determines their usefulness when it comes to intubating the critically ill child is their onset of action. Even though a classical rapid sequence induction is rarely performed in a critically ill child, as it is common practice to provide gentle face mask ventilation during the apnoea period prior to intubation (while waiting for the muscle relaxant to take effect), the speed of onset of the muscle relaxant is no less important. By choosing a muscle relaxant with a shorter onset of action you can minimise the duration of face mask ventilation and the complications that go with it (failed or inadequate face mask ventilation leading to hypoxia, gastric distention impairing ventilation and increasing risk of aspiration, time wasted that could be spend doing another task). Only ...
Should be avoided due to a significant risk of hyperkalemia.. Ferguson et al described four patients with chronic/relapsing polyneuropathy who developed life-threatening arrhythmias following succinylcholine administration, although in this instance SCh was presumed, but not documented to be the cause (1). Reilly and Hutchinson described a case (2) in which a 51-year-old man developed unstable V-tach leading to cardiac arrest (K increased from 4.3 to 8.6) and death following SCh administration for an intubation during a GBS relapse. Most recently an occurence was documented in Belgium (3). Note that this risk may persist even after the disorder has run its course, as has been documented in at least one case report (4), in this case of a pregnant woman one month post-recovery. Vecuronium and rocuronium, both of which have minimal cardiovascular effects (unlike pancuronium, which does), are recommended. Unfortunately, these patients may be either overly or under sensitive to non-depolarizing ...

Intrinsic lymphatic partition rate of mepitiostane, epitiostanol, and oleic acid absorbed from rat intestine.Intrinsic lymphatic partition rate of mepitiostane, epitiostanol, and oleic acid absorbed from rat intestine.

Androstanols / blood, pharmacokinetics*. Animals. Bile Ducts / physiology. Female. Intestinal Absorption*. Lymph / metabolism. ... 0/Androstanols; 0/Oleic Acids; 112-80-1/Oleic Acid; 21362-69-6/mepitiostane; 2363-58-8/epitiostanol ...
more infohttp://www.biomedsearch.com/nih/Intrinsic-lymphatic-partition-rate-mepitiostane/1796049.html

Delayed recovery from rocuronium block in an infant.Delayed recovery from rocuronium block in an infant.

Androstanols / pharmacology*. Cleft Lip / surgery*. Humans. Infant. Male. Neuromuscular Blockade*. Neuromuscular ... 0/Androstanols; 0/Neuromuscular Nondepolarizing Agents; WRE554RFEZ/rocuronium From MEDLINE®/PubMed®, a database of the U.S. ...
more infohttp://www.biomedsearch.com/nih/Delayed-recovery-from-rocuronium-block/23265038.html

4,5-epoxy-17-hydroxy-2-methylsulfonyl-3-androstanone
     Summary Report | CureHunter4,5-epoxy-17-hydroxy-2-methylsulfonyl-3-androstanone Summary Report | CureHunter

4,5-epoxy-17-hydroxy-2-methylsulfonyl-3-androstanone: structure given in first source; an HIV-1 Tat inhibitor; RN given refers to (2B,4A,5A,17B)-isomer
more infohttp://www.curehunter.com/public/keywordSummaryC083425-4-5-epoxy-17-hydroxy-2-methylsulfonyl-3-androstanone.do

AJOU Open Repository: Browsing DSpaceAJOU Open Repository: Browsing DSpace

1 *Androstanols * 2 *Anesthesia * 1 *Anesthesia Recovery Period * 1 *Anesthesia, Caudal * 1 *Anesthesia, Inhalation ...
more infohttp://repository.ajou.ac.kr/handle/201003/14299/browse?type=subject&

AJOU Open Repository: Browsing DSpaceAJOU Open Repository: Browsing DSpace

1 *Androstanols * 2 *Anesthesia * 1 *Anesthesia Recovery Period * 1 *Anesthesia, Caudal * 1 *Anesthesia, Inhalation ...
more infohttp://repository.ajou.ac.kr/browse?type=subject&order=ASC&rpp=60&etal=-1&sort_by=0&page=733&

DeCS Ingl s+escopoDeCS Ingl s+escopo

D04.210.500.054.040 Androstanols .. D04.210.500.054.040.248 Dihydrotestosterone .. D04.210.500.054.079 Androstenes .. D04.210. ...
more infohttp://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Norandrostenolone

DeCS Ingl s+escopoDeCS Ingl s+escopo

D04.210.500.054.040 Androstanols .. D04.210.500.054.040.632 Oxymetholone .. D04.210.500.365 Estranes .. D04.210.500.365.415 ...
more infohttp://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Menogaril,%20

List of MeSH codes (D04) - WikipediaList of MeSH codes (D04) - Wikipedia

... androstanols MeSH D04.808.054.040.080 --- androstane-3,17-diol MeSH D04.808.054.040.129 --- androsterone MeSH D04.808.054.040. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D04)

NAVER Academic > Search...NAVER Academic > Search...

Adult, Androstanols, pharmacology, Computers, Female, Fentanyl, Glottis, drug effects, Humans, Intubation, Intratracheal, ...
more infohttps://academic.naver.com/search.naver?field=3&query=ANESTHESIA+AND+ANALGESIA+109%EA%B6%8C+3%ED%98%B8

NAVER Academic > Search...NAVER Academic > Search...

Adult, Anaphylaxis, chemically induced, Androstanols, administration & dosage, adverse effects, Anesthesia, General, Cesarean ...
more infohttps://academic.naver.com/search.naver?field=3&query=Journal+of+Anesthesia+31%EA%B6%8C+1%ED%98%B8&page=2

Trilostane - DrugBankTrilostane - DrugBank

Androstanols. *Antiadrenal Preparations. *Anticorticosteroids. *Antineoplastic Agents. *Corticosteroids. *Corticosteroids for ...
more infohttps://www.drugbank.ca/drugs/DB01108

Vecuronium - DrugBankVecuronium - DrugBank

Androstanols. *Anticholinergic Agents. *Central Nervous System Depressants. *Cholinergic Agents. *Muscle Relaxants. *Muscle ...
more infohttps://www.drugbank.ca/drugs/DB01339

Evidence Central | By Topic AEvidence Central | By Topic A

Topics beginning with By Topic A were found in Evidence Central. Evidence Central is an integrated web and mobile solution that helps clinicians quickly answer etiology, diagnosis, treatment, and prognosis questions using the latest evidence-based research.
more infohttps://evidence.unboundmedicine.com/evidence/index/Cochrane/By_Topic/A

Anesthesia, Closed-Circuit | The Chopra LibraryAnesthesia, Closed-Circuit | The Chopra Library

A model-based closed-loop control system is presented to regulate hypnosis with the volatile anesthetic isoflurane. Hypnosis is assessed by means of the bispectral index (BIS), a processed parameter derived from the electroencephalogram. Isoflurane is administered through a closed-circuit respiratory system. The model for control was identified on a population of 20 healthy volunteers. It consists of three parts: a model for the respiratory system, a pharmacokinetic model and a pharmacodynamic model to predict BIS at the effect compartment. A cascaded internal model controller is employed ...
more infohttp://isharonline.org/tags/anesthesia-closed-circuit

A comparison of rocuronium and lidocaine for the prevention of postoperative myalgia after succinylcholine administration. |...A comparison of rocuronium and lidocaine for the prevention of postoperative myalgia after succinylcholine administration. |...

A comparison of rocuronium and lidocaine for the prevention of postoperative myalgia after succinylcholine administration.
more infohttps://scholars.duke.edu/display/pub739780

Welcome to LibAge, the ageing reference resourceWelcome to LibAge, the ageing reference resource

You can search for any reference by title, author, date, editor, journal and publisher. Searching is case insensitive, and allows for only partial terms (e.g. seq with pickup both RNA-Seq and sequencing) matching. You can also use advanced queries that are detailed here. ...
more infohttp://libage.ageing-map.org/entries/tags/503/

Welcome to LibAge, the ageing reference resourceWelcome to LibAge, the ageing reference resource

Androstanols/pharmacology *Animals *Calcium/physiology *Cycloheximide/pharmacology *Electric Conductivity *Hippocampus/drug ...
more infohttp://libage.ageing-map.org/entries/tags/939/

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta.  - PubMed - NCBIAndrostane metabolites bind to and deactivate the nuclear receptor CAR-beta. - PubMed - NCBI

Androstanols/metabolism*. *Animals. *Binding Sites. *COS Cells. *Ligands. *Receptors, Cytoplasmic and Nuclear/antagonists & ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/9783588?dopt=Abstract

In reply: Calibration of the neuromuscular monitor: Is it necessary?<...In reply: Calibration of the neuromuscular monitor: Is it necessary?<...

TY - JOUR. T1 - In reply. T2 - Calibration of the neuromuscular monitor: Is it necessary?. AU - Bhananker, Sanjay M.. AU - Treggiari, Miriam. AU - Thilen, Stephan R.. PY - 2016/3/1. Y1 - 2016/3/1. UR - http://www.scopus.com/inward/record.url?scp=84957975160&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84957975160&partnerID=8YFLogxK. U2 - 10.1007/s12630-015-0536-3. DO - 10.1007/s12630-015-0536-3. M3 - Article. VL - 63. SP - 356. EP - 357. JO - Canadian Anaesthetists Society Journal. JF - Canadian Anaesthetists Society Journal. SN - 0832-610X. IS - 3. ER - ...
more infohttps://ohsu.pure.elsevier.com/en/publications/in-reply-calibration-of-the-neuromuscular-monitor-is-it-necessary-2

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