Appetite Depressants: Agents that are used to suppress appetite.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Dehydroepiandrosterone Sulfate: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.Weight Gain: Increase in BODY WEIGHT over existing weight.Body Composition: The relative amounts of various components in the body, such as percentage of body fat.Energy Intake: Total number of calories taken in daily whether ingested or by parenteral routes.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Xenobiotics: Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.Metabolic Detoxication, Drug: Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.Receptors, Cytoplasmic and Nuclear: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.Cytochrome P-450 CYP3A: A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.Pregnenolone Carbonitrile: A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Oxidoreductases, N-DemethylatingRifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.Chrysenes: 1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.Gene Products, tat: Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)HIV-2: An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition. It shares serologic reactivity and sequence homology with the simian Lentivirus SIMIAN IMMUNODEFICIENCY VIRUS and infects only T4-lymphocytes expressing the CD4 phenotypic marker.PhenanthrenesNorleucine: An unnatural amino acid that is used experimentally to study protein structure and function. It is structurally similar to METHIONINE, however it does not contain SULFUR.tat Gene Products, Human Immunodeficiency Virus: Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.Drug and Narcotic Control: Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Legislation, Drug: Laws concerned with manufacturing, dispensing, and marketing of drugs.Anabolic Agents: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Designer Drugs: Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.Writing: The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.Methandrostenolone: A synthetic steroid with anabolic properties that are more pronounced than its androgenic effects. It has little progestational activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1188)Nandrolone: C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.United StatesDrugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Names: Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.United StatesProfessional Autonomy: The quality or state of being independent and self-directing, especially in making decisions, enabling professionals to exercise judgment as they see fit during the performance of their jobs.Health Services Accessibility: The degree to which individuals are inhibited or facilitated in their ability to gain entry to and to receive care and services from the health care system. Factors influencing this ability include geographic, architectural, transportational, and financial considerations, among others.Carcinoma, Lewis Lung: A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.Myxomatosis, InfectiousSiphonaptera: An order of parasitic, blood-sucking, wingless INSECTS with the common name of fleas.Pulmonary Stretch Receptors: Stretch receptors found in the bronchi and bronchioles. Pulmonary stretch receptors are sensors for a reflex which stops inspiration. In humans, the reflex is protective and is probably not activated during normal respiration.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Myxoma virus: The type species of LEPORIPOXVIRUS causing infectious myxomatosis, a severe generalized disease, in rabbits. Tumors are not always present.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Boxing: A two-person sport in which the fists are skillfully used to attack and defend.PhilippinesJuglans: A plant genus of the family JUGLANDACEAE that provides the familiar walnut.Plant Bark: The outer layer of the woody parts of plants.Brain Injury, Chronic: Conditions characterized by persistent brain damage or dysfunction as sequelae of cranial trauma. This disorder may result from DIFFUSE AXONAL INJURY; INTRACRANIAL HEMORRHAGES; BRAIN EDEMA; and other conditions. Clinical features may include DEMENTIA; focal neurologic deficits; PERSISTENT VEGETATIVE STATE; AKINETIC MUTISM; or COMA.American Medical Association: Professional society representing the field of medicine.Tarsiidae: The single family of PRIMATES in the infraorder TARSII, suborder HAPLORHINI. It is comprised of one genus, Tarsius, that inhabits southern Sumatra, Borneo, Sulawesi, and the Philippines.Dilleniaceae: A plant family of the order Dilleniales, subclass Dilleniidae, class Magnoliopsida.Exsanguination: Rapid and extreme blood loss leading to HEMORRHAGIC SHOCK.Anatomic Variation: Peculiarities associated with the internal structure, form, topology, or architecture of organisms that distinguishes them from others of the same species or group.

Transfer of the 1-pro-R and the 1-pro-S hydrogen atoms of ethanol in metabolic reductions in vivo. (1/122)

The transfer of deuterium from [1 R-2H]ethanol and [1 S-2H]-ethanol to reduced metabolites of administered compounds was measured in female rats provided with bile fistulas. Administered cyclohexanone was reduced to cyclohexanol, and in this reduction hydrogen was transferred only from the 1-pro-R position of the ethanol. The deuterium content in the cyclohexanol was about 67% of that in the ethanol. In the reduction of the 17-oxo group in 3beta-hydroxy-5alpha-androstan-17-one, hydrogen was transferred both from the 1-pro-R position and the 1-pro-S position, resulting in degrees of labelling that were about 25% and 2%, respectively, of those in the specific positions of the ethanols. The 1-pro-R and 1-pro-S positions of ethanol contributed about 9% and 5%, respectively, of the 3beta hydrogen in lithocholic acid formed from 3-oxo-5beta-cholanoic acid. The results indicate that alcohol dehydrogenase and aldehyde dehydrogenase do not share a common pool of NAD, and that NADH formed during acetaldehyde oxidation is utilized for reductions in the cytosol to a smaller extent than the NADH formed in the alcohol dehydrogenase reaction. This result supports the concept that aldehyde oxidation is mainly an intramitochondrial process. The relatively extensive utilization of the 1-pro-S hydrogen of ethanol in the reduction of 3-oxo-5beta-cholanoic acid, that is probably NADPH-dependent, indicates that cytosolic NADPH may be produced from malate or isocitrate formed intramitochondrially.  (+info)

Induction of delta-aminolevulinic acid synthetase in isolated rat liver cells by steroids. (2/122)

The role of steroids in regulation of delta-aminolevulinic acid synthetase has been studied in isolated rat liver cell suspensions under conditions previously shown to support inducation of the enzyme by drugs. Addition of a variety of C-19 and C-21 steroids to cell suspensions resulted, after 4 to 6 hours of incubation, in 2- to 5-fold increase in the activity of delta-aminolevulinic acid synthetase as measured in liver cell homogenates. The increase was prevented by cycloheximide. The most active steroid inducers tested were pregnene or pregnane derivatives with keto or hydroxyl groups at C-3 and C-20; in particular a beta-hydroxyl group at C-20 enhanced activity. These C-21 steroids at optimal initial concentrations caused 3- to 5-fold induction over 4 hours. A number of C-19 androstene and androstane compounds caused 2- to 3-fold inducation over the same period. Hydrocortisone had no effect. For a variety of androstane and pregnane derivatives, inducation by 5alphaH steroids was as great as or greater than that by 5betaH compounds, in contrast to previous findings in chick embryo liver. Induction of delta-aminolevulinic acid synthetase by steroids in isolated liver cells was shown to be subject to feedback repression by hemin.  (+info)

Regulation and substrate specificity of a steroid sulfate-specific hydroxylase system in female rat liver microsomes. (3/122)

The sulfate-specific hydroxylase system in liver microsomes from rats has been investigated with respect to its substrate specificity. Eighteen different C18, C19, C21, and C27 steroid sulfates and the coresponding free steroids have been incubated with microsomal preparations from male and female rats. The sulfate-specific system was only present in preparations from female rats and primarily catalyzed hydroxylation in position 15beta but also in position 7beta. In contrast to this, male liver microsomes were more efficient than female liver microsomes in hydroxylating free steroids; these were hydroxylated in positions 2alpha,2beta,6alpha,6beta,7alpha,7beta,16alpha, and 18. The sulfate-specific hydroxylase system in female liver microsomes was found to have rigid requirements c concerning the structure of ring D in the substrate molecule; only 17beta-sulfates (C18 and C19 steroids) and 21-sulfates (C21 steroids) were hydroxylated. Less rigid criteria, however, exist concerning the structure of ring A. The following K-m values were determined for microsomal 15beta-hydroxylation: 5alpha-androstane-3alpha,17beta-diol disulfate, 17.2 muM; 5beta-androstane-3alpha,17beta-diol disulfate, 16muM;5alpha-androstane-3alpha,17beta-diol 17-sulfate, 26 muM; and estradiol 17-sulfate, 181 muM. Some of the regulatory mechanism controlling the activity of the sex-specific 15beta-hydroxylase system also have been studied and compared to the mechanism controlling the activities of the less specific 2alpha-, 7alpha-, and 18-hydroxylase systems active on 5alpha-[4-14C]androstane-3alpha,17beta-diol. Biliary drainage did not affect the 15beta-hydroxylase activity, whereas the 2alpha- and 7alpha-hydroxylase activities decreased..  (+info)

Antiarrhythmic, haemodynamic and metabolic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one hydrochloride in greyhounds following acute coronary artery ligation. (4/122)

1 The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. 2 ORG6001 administered either intravenously (2-10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. 3 In dogs pretreated with ORG6001, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. 4 Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. 5 These results suggest that ORG6001 may possess distinct advantages over presently-used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction.  (+info)

Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. (5/122)

Methoxychlor, a structural analog of the DDT pesticide, was previously shown to induce rat hepatic CYP2B and -3A mRNAs and the corresponding proteins [J Biochem Mol Toxicol 1998;12:315-323], Additionally, methoxychlor was found to activate the constitutive androstane receptor (CAR) system and induce CYP2B6 (J Biol Chem 1999;274:6043-6046), suggesting a mechanism for methoxychlor-mediated cytochrome P450 (P450) 2B induction. However, it has not been established whether CAR activation and P450 induction was due to methoxychlor per se and/or due to its metabolites. Also, a possible link between the estrogenic potency of methoxychlor metabolites and CAR activation or P450 induction was not investigated. The current study explores the ability of methoxychlor and its metabolites to activate CAR and whether their potency of CAR activation correlates with their respective estrogenicity. Methoxychlor and its metabolites [mono-OH-M [1,1,1-trichloro-2 (4-hydroxyphenyl)-2'-(4-methoxyphenyl)ethane]; bis-OH-M [1,1,1-trichloro-2,2'-bis(4-hydroxyphenyl)ethane]; ring-OH-M [1,1,1-trichloro-2(4-methoxyphenyl)-2'-(3-hydroxy-4-methoxyphenyl)ethane]; and tris-OH-M [1,1,1-trichloro-2(4-hydroxyphenyl)-2'-(3,4-dihydroxyphenyl)ethane]] were found to be potent activators of CAR. Dose response curves indicated that tris-OH-M is a more potent CAR activator than methoxychlor, mono-OH-M, and bis-OH-M. Since tris-OH-M is a much weaker estrogen receptor-alpha agonist than mono-OH-M and bis-OH-M, it seems that estrogenicity is not a significant factor in CAR activation. These findings indicate that alteration of methoxychlor-benzene rings, i.e., generation of phenolic constituents, does not appreciably alter CAR activation and suggest that a common structural motif in the methoxychlor class of compounds controls CAR activation. Studies are needed to identify the structural motif necessary for CAR activation and CYP2B induction.  (+info)

Local anaesthetic and antiarrhythmic properties of an aminosteroid: 3alpha-dimethyl-amino-5alpha-androstan-2beta-ol-17-one (Org. NA 13). (6/122)

1. The aminosteroid Org. NA13 (3alpha-dimethylamino-5alpha-androstan-2beta-ol-17-one) was shown to be a more potent local anaesthetic than lignocaine in rats and guinea-pigs. 2. Experimental arrhythmias induced in mice by chloroform, in rats by aconitine and in dogs by coronary artery ligation were corrected by Org. NA13 at doses from 10 to 50 mg/kg intravenously. 3. In contrast to lignocaine, other local anaesthetics and beta-adrenoceptor blocking drugs, Org. NA 13 did not show any activity against the arrhythmias induced by ouabian in dogs. 4. The acute toxicity in whole animals and myocardial toxicity in the rabbit isolated atrium appeared to be less than that observed with lignocaine.  (+info)

Steroid induction of delta-aminolevulinic acid synthase and porphyrins in liver. Structure-activity studies and the permissive effects of hormones on the induction process. (7/122)

Quantitative aspects and structure-activity relationships of the inducing effects of natural steroids on delta-aminolevulinic acid (ALA) synthase and porphyrins have been investigated in monolayer cultures of chick embryo liver cells maintained in a serum-free medium as well as in the chick embryo liver in ovo. Many 5 alpha and 5 beta metabolites of neutral C-19 and C-21 hormones and hormone precursors stimulated porphyrin formation and ALA-synthase induction in the cultured liver cells as we have previously described. In these inducing actions a number of 5 beta epimers (A:B cis) were found to be more potent than their corresponding 5 alpha epimers (A:B trans). The structure-activity relationship between 5 beta and 5 alpha steroid epimers with respect to ALA-synthase induction in culture was also found to prevail with respect to induction of this enzyme in chick embryo liver in ovo. Hemin in concentrations of 2 x 10(-7) M inhibited steroid induction of porphyrin formation, and CaMgEDTA enhanced the responsiveness of the cultured liver cells to steroids by approximately 10 times. The addition of insulin, or insulin plus hydrocortisone or insulin plus hydrocortisone plus triiodothyronine, was important for the maintenance of protein synthesis and essential for maximal expression of the ability of steroids to induce porphyrins and ALA-synthase in the "permissive" effect which insulin, hydrocortisone, and triiodothyronine exert on allylisopropylacetamide induction of porphyrins and ALA-synthase also extends to the induction process which is elicited by natural steroids. These findings also strongly suggest that the regulation of hepatic porphyrin-heme biosynthesis by endogenous as well as exogenous chemicals is significantly influenced by the internal hormonal milieu.  (+info)

Stereochemical aspects of the interaction between steroidal diamines and DNA. (8/122)

A complete series of stereoisomeric quaternised diaminoandrostanes, differing in their stereochemistry at the 3,5 and 17 positions, has been examined for effects on the thermal denaturation of calf thymus DNA and for the ability to remove and reverse the supercoiling of closed circular duplex PM2 DNA. In both types of test the eight isomers rank in the same order of effectiveness. The preferred stereochemistry for the quaternary substituents at positions 3 and 17 is beta; of these the orientation of the 17- substituent is more critical. Folding of the steroid skeleton between the A and B rings, as in 5beta-androstanes, diminishes effectiveness but does not necessarily abolish the effect on supercoiling. The over-riding importance of the C-D ring end of the steroid nucleus bearing a 17beta-amino substituent is confirmed by a comparison of the effects of five mon-amino androstanes. Relative helix=unwinding angles per bound steroidal diamine molecule have been determined for four of the isomers; for three 17beta compounds the estimated values are similar to that previously reported for irehdiamine A. For a fourth isomer the angle is 0.22 times that of ethidium, the lowest yet determined for any DNA-binding drug. The results lend further support to the argument that intercalation can be reled out, and alternative models for the binding mechanism are discussed.  (+info)

*Constitutive androstane receptor

Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as ...

*List of androstanes

This is a list of androstanes, or androstane derivatives. Androstanol 3α,5α-Androstanol (5α-androstan-3α-ol) - an endogenous ...

*17β-Hydroxysteroid dehydrogenase

Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion ...

*Androstane

Estrane and pregnane List of androstanes Wilson JD (1996). "Role of dihydrotestosterone in androgen action". Prostate Suppl. 6 ...

*Neurosteroid

They include the androstanes androstadienol, androstadienone, androstenol, and androstenone and the estrane estratetraenol. ... the androstanes dehydroepiandrosterone (DHEA; prasterone), and dehydroepiandrosterone sulfate (DHEA-S; prasterone sulfate), and ...

*1-Androsterone

... and other 1-dehydrogenated androstanes. The drug has been sold on the Internet as a designer steroid and "dietary supplement". ...

*Androsterone

List of androgens/anabolic steroids List of neurosteroids § Androstanes List of neurosteroids § Pheromones and pherines Motofei ...

*Pregnenolone

In contrast to the androstanes, 50 or 100 mg oral pregnenolone has been found to significantly and in fact "strongly" increase ...

*Progestin

... and the androstanes (e.g., danazol, ethisterone) and estranes (e.g., norethisterone, levonorgestrel), which are testosterone ...
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Growth Hormone Releasing Peptides | IMMUNE SYSTEM MODULATORS | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | METHODS FOR THE SYNTHESIS OF CERAGENINS | METHODS FOR THE SYNTHESIS OF CERAGENINS |
局在化一重項ビラジカルの反応性に及ぼす窒素原子効果と置換基効果, 基礎有機化学討論会要旨集(基礎有機化学連合討論会予稿集), 2011巻, 0号, pp.350-pp.350, ...
Two years after arriving in America, Turkish center Enes Kanter speaks English fluently. But it wasnt always that way.. When I first got here, I couldnt speak any, he says now. My dad just taught me to say, Hello, and My name is Enes Kanter, and thats it.. In many ways, hes still making his introduction.. Unlike the other guy the Timberwolves most likely will choose if they keep the second overall pick, Kanter, in these weeks leading to Thursdays NBA draft, has done almost everything asked of him by NBA teams to whom the rugged 6-11 center still is something of a mystery.. Arizonas Derrick Williams worked out only for the Wolves and Cleveland -- owners of the drafts first two picks -- and went to Chicago for last months combine for only interviews and physical testing because, after a sensational sophomore season, he said, What do you want me to prove? I did that during the season.. Kanter, meanwhile, did every drill requested in Chicago and has auditioned for at least five ...
Buy high quality 3-(2-Deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one-13C3 from toronto research chemicals Inc.
English Synonyms: BOLDENONE-10-UNDECENOATE;boldenone undec-10-enoate;BOLDENONE UNDECYLENATE;DEHYDROTESTOSTERONE UNDECYLENATE;1-DEHYDROTESTOSTERONE UNDECYLENATE;17b-hydroxyandrosta-1,4-dien-3-one 10-undecenoate;17b-[(1-oxo-10-undecenyl)oxy]-androsta-1,4-dien-3-one;17-HYDROXYANDROSTA-1,4-DIENE-3-ONE-17-UNDECENOATE ...
Trichomonosis, caused by the protozoan parasite Trichomonas vaginalis, is a curable sexually transmitted disease that is most commonly encountered worldwide. Increasing importance of trichomoniasis and emerging of resistance against metronidazole lead to search for alternative drugs with different mode of activity. The purpose of this study was to determine in vitro activity of ceragenins (CSA-13, CSA-44, CSA-13, and CSA-138) against the metronidazole-susceptible (ATCC 30001) and metronidazole-resistant (ATCC 50138) strains of T. vaginalis. The effective concentrations were evaluated using two strains of T. vaginalis with different metronidazole susceptibilities (ATCC 30001 and ATCC 50138) in the presence of dilution series of ceragenins in 24-well microtitre assays. Overall, all the ceragenins killed the metronidazole-susceptible (ATCC 30001) and metronidazole-resistant (ATCC 50138) strains of T. vaginalis (p,0.05). With regard to the their effects against the studied strains of T. vaginalis, ...
English Synonyms: 17-alpha-Methyl-2-hydroxymethylene-17-hydroxy-5-alpha-androstan-3-one;17-beta-androstan-3-one,17-hydroxy-2-(hydroxymethylene)-17-methyl-5-alph;17-beta-Hydroxy-2-(hydroxymethylene)-17-alpha-methyl-5-alpha-androstan-3-one;17-beta-hydroxy-2-(hydroxymethylene)-17-methyl-5-alpha-androstan-3-on;17beta-hydroxy-2-(hydroxymethylene)-17-methyl-5alpha-androstan-3-on;17-beta-Hydroxy-2-hydroxymethylene-17-alpha-methyl-3-androstanone;17-hydroxy-2-(hydroxymethylene)-17-methyl-,(alpha,17beta)-androstan-3-on;17-Hydroxy-2-(hydroxymethylene)-17-methyl-5-alpha-17-beta-androst-3-one ...
A process for the preparation of random propylene copolymers contairing copolymerized Cz-C1o-alk-l-enes by polymerization of propylene and Cz-C1o-alk-l- enes in the presence of a Ziegler-Natta catalyst system comprising a titanium- containing solid component a) comprising a compound of magnesium, a halogen, silica gel as support and a carboxylic ester as electron donor compound, and also, as cocatalysts, an aluminum compound b) and a further electron donor compound c), where propylene and the Cz-C1o-alk-l-enes are polymerized with one another at from 50 to 100°C at pressures in the range from 15 to 40 bar and mean residence times of from 0.5 to 5 hours and the support used in the titanium-containing solid component is a silica gel which has a mean particle diameter of from 5 to 200 J.tm, a mean particle diameter of the primary particles of from 1 to 10 J.tm and voids or channels having a mean diameter of from 1 to 10 J.tffi, which voids or channels have a macroscopic proportion by volume based ...
La testosterone 17beta-deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: testosterone + NAD+ ⇄ androst-4-ene-3,17-dione + NADH + H+ Endahl, G.L., Kochakia, C.D. and Hamm, D., Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver, in J. Biol. Chem., vol. 235, 1960, pp. 2792-2796, Entrez PubMed 13696735. Sweat, M.L., Samuels, L.T. and Lumry, R., Preparation and characterisation of the enzyme which converts testosterone to androstendione, in J. Biol. Chem., vol. 185, 1950, pp. 75-84, Entrez PubMed 15436478. Villee, C.A. and Spencer, J.M., Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver, in J. Biol. Chem., vol. 235, 1960, pp. 3615-3619. idrossisteroide ...
Accepted name: 3-ketosteroid 9α-monooxygenase. Reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9α-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O. Other name(s): KshAB; 3-ketosteroid 9α-hydroxylase. Systematic name: androsta-1,4-diene-3,17-dione,NADH:oxygen oxidoreductase (9α-hydroxylating). Comments: The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It is a two-component system consisting of a terminal oxygenase (KshA) and a ferredoxin reductase (KshB). The oxygenase contains a Rieske-type iron-sulfur center and non-heme iron. The reductase component is a flavoprotein containing an NAD-binding domain and a plant-type iron-sulfur cluster. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: References:. 1. Petrusma, M., Dijkhuizen, L. and ...
Used for efficient production of key steroid intermediates (androst-4-ene-3,17-dione, androsta-1,4-diene-3,17-dione, 9-hydroxy androst-4-ene-3,17-dione) from phytosterol ...
250 µCi quantities of Androst-4-ene-3, [1,2,6,7-3H(N)]-, 17-Dione are available for your research. Application of [3H] Androstenedione can be found in: effects of HCG and PMS on bioconversion in steroid biochemistry, breast cancer cell research, inhibition study of human placental aromatase in steroid biochemistry, in vitro metabolism studies in steroid chemistry; etc. ...
4 Major Functions The four major functions of the skeleton are: 1. Shape and support 2. Movement 3. Protection 4. Blood Production Try to remember: Should Mothers Protect Babies
2,6-Dihydro-3-methyl-5-(trifluoromethyl)pyrimido[5,4-e]-1,2,4-triazine-7(1H)-thione/ACM32709356 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Turgay Celik, Esra Goktas, Hasan Kutsi Kabul, Sevket Balta, Atila Iyisoy, Selim Kilic, Mehmet Erdem, Muhammet Olgun, Huseiyn Aldemir, Salih Dasdelen, Okan Dalak, Fatih Kecilioglu, Fatma Nurefsan Selek, Ali Uygun, Bayram Kurt, Atilla Yilmaz, Orhan Mert, Sayed Mujtaba Haidari, Hamza Berlik, Ozlem Topcu, Israfil Akbay, Enes Gumler, Ismail Karakose, Aydin Mentese, Recep Tayip ...
Cancer is caused by an accumulation of genetic alterations that confer a survival advantage to the neoplastic cell. J. L. Jameson(p73) Oncogenes are "[g]enes that normally play a role in growth but, when overexpressed or mutated, can foster the growth of cancer." Oncogenes were discovered and characterized in viruses and animal experimental systems. These genes exist widely outside the systems in which they were discovered, and their normal cellular homologues are important in cell division and differentiation. Human oncogenes should be expressed according to style for human gene symbols (see , Human Gene Nomenclature). Mouse oncogenes (and other nonhuman oncogenes) should Less ...
Cancer is caused by an accumulation of genetic alterations that confer a survival advantage to the neoplastic cell. J. L. Jameson(p73) Oncogenes are "[g]enes that normally play a role in growth but, when overexpressed or mutated, can foster the growth of cancer." Oncogenes were discovered and characterized in viruses and animal experimental systems. These genes exist widely outside the systems in which they were discovered, and their normal cellular homologues are important in cell division and differentiation. Human oncogenes should be expressed according to style for human gene symbols (see , Human Gene Nomenclature). Mouse oncogenes (and other nonhuman oncogenes) should Less ...
by Beser, Omer F and Cokugras, Fugen Cullu and Erkan, Tulay and Kutlu, Tufan and Yagci, Rasit V and Ertem, Deniz and Yaşöz, Güniz and Yüksekkaya, Hasan Ali and Artan, Reha and Önal, Zerrin and Coşkun, Mehmet Enes and Aydoğan, Ayşen and Zorlu, Pelin and Akçaboy, Meltem and Tosun, Mahya Sultan and Urgancı, Nafiye and Kaya, Reyhan Gümüştekin and Satar, Mehmet and Yüce, Aysel and Karhan, Asuman Nur and Civan, Hasret Ayyıldız and Kasırga, Erhun and Volkan, Burcu and Certel, Alev Cansu and Güzelçiçek, Ahmet and Özkan, Tanju and Demirören, Kaan and Akşit, Sadık and Gökçe, Şule and Kızılcan, Sirmen and Dalgıç, Buket and Demirtaş, Zeliha and Karbuz, Adem and Kalaycı, Ayhan Gazi and Gülbahçe, Aliye and Sayar, Talip and Güler, Serhat and Aktar, Fesih and Kansu, Aydan and Altuntaş, Cansu and Ağalıoğlu, Dilfuza and Arslan, Duran and Arslan, Nur and Karakurt, Hasan and Sazak, Soner and Halıcıoğlu, Oya Baltalı and İnce, Gülberat and Üstündağ, Gonca and Soysal, ...
The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene. CAR is a member of the nuclear receptor superfamily and along with pregnane X receptor (PXR) functions as a sensor of endobiotic and xenobiotic substances. In response, expression of proteins responsible for the metabolism and excretion of these substances is upregulated. Hence, CAR and PXR play a major role in the detoxification of foreign substances such as drugs. Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as antagonists, were the basis for the naming of this receptor. More recently, dehydroepiandrosterone (DHEA), also an androstane, has been found to be an endogenous agonist of the CAR. CAR is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. Unlike most nuclear receptors, this transcriptional ...
Unsatisfied and unconvinced by what he was being taught about evolution at Marmara University in Istanbul, Turkey, 21-year old student Enes Kayan knew there was another side which was never presented in his courses. So in 2012, Enes, a member of the Marmara Young Vision Student Club, decided to organize a symposium in which he and other Marmara students could hear alternative views on evolution, including intelligent design. The idea that evidence against Darwinism, and even for intelligent design, could be freely presented at a university angered some students and professors, and about 300 of them staged a protest, which Enes said actually worked to his advantage as it brought publicity to the event, which was held on May 16-17, 2012 ...
La 7alfa-idrossisteroide deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 3α,7α,12α-triidrossi-5β-ciolanato + NAD+ ⇄ 3β,12α-diidrossi-7-osso-5β-ciolanato + NADH + H+ Lenzima catalizza lossidazione del gruppo 7α-idrossile degli acidi biliari e degli alcoli sia nella forma libera che legata. Gli enzimi di Bacteroides fragilis e Clostridium possono utilizzare anche il NADP+. Macdonald, I.A., Williams, C.N. and Mahony, D.E., 7α-Hydroxysteroid dehydrogenase from Escherichia coli B: preliminary studies, in Biochim. Biophys. Acta, vol. 309, 1973, pp. 243-253, Entrez PubMed 4581498. Macdonald, I.A. and Roach, P.D., Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum, in Biochim. Biophys. Acta, vol. 665, 1981, pp. 262-269, Entrez PubMed 6945134. Haslewood, E.S. and Haslewood, G.A.D., The specificity of a 7α-hydroxy steroid dehydrogenase from Escherichia coli, in Biochem. J., vol. 157, 1976, pp. ...
Extractable filler for inserting medicine into animal tissue | Extractable filler for inserting medicine into animal tissue | 4-aminomethyl-1-aryl-cyclohexylamine compounds | Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives | Inhibitors of 11-.beta.-hydroxy steroid dehydrogenase type 1 |
When an autologous blood product is collected but not transfused, OPPS providers should bill Procedure 86890 (autologous blood or component, collection, processing, and storage; predeposited) or 86891(autologous blood or component, collection, processing, and storage; intra- or postoperative salvage) and the number of units collected but not transfused. Procedure 86890 and 86891 are intended to provide payment for the additional resources needed to provide these services, which are not captured when a blood product HCPCS code is not billed. Because billing 86890 or 86891 is only indicated when autologous blood is collected but not transfused, the OPPS provider should bill 86890 or 86891 on the date when the OPPS provider is certain the blood will not be transfused (i.e., date of a procedure or date of outpatient discharge), rather than on the date of the products collection or receipt from the supplier ...
In what part of the body is a sharks blood made? This was the subject of an enquiry that was recently sent to the Australian Museum.
There are no specific protocols for Recombinant Human Constitutive androstane receptor protein (ab81846). Please download our general protocols booklet
Creative-Proteomics offer cas 516-55-2 5-ALPHA-PREGNAN-3-BETA-OL-20-ONE (17A,21,21,21-D4, 97%+) 96% PURE. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Health,Another importance of stem cells comes to the fore front as claimed by...The feat is to grow a human prostate gland in mice using embryonic...This would be helpful in treatment for prostate cancer and other dis... Monash University at Melbourne researchers had combined human emb... Weve taken these embryonic stem cells to a point where they are...,Mice,model,becomes,surrogate,for,human,prostate,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Read "A green organocatalyzed one-pot protocol for efficient synthesis of new substituted pyrimido[4,5-d]pyrimidinones using a Biginelli-like reaction, Research on Chemical Intermediates" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
... is an emerging biopharmaceutical company focused on commercializing a novel class of patented compounds known as ceragenins or CSAs. These compounds have broad-spectrum activity mimicking those of endogenous antimicrobial peptides such as LL-37. CSAs, however, are not peptides; rather synthetic small molecules that can be manufactured at large scale and are not subject […]. Read More. ...
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An open letter in support of transformative biotechnology and social innovation: SANKO University Innovation Summit in Medicine and Integrative Biology, Gaziantep, Turkey, May 5-7, 2016, Eyüp Saygılı, Alaa Abou-Zeid, Salih Akkın, Eleni Aklillu, İbrahim Barlas, Alexander Borda-Rodriguez, Filiz Boschele, Zafer Çetin, Enes Coşkun, Yavuz Coşkun, Güner Dağlı, Türkan Dai, Collet Dandara, Türkay Dereli, Levent Elbeyli, Laszlo Endrenyi, Can Eyigün, Alexandros Georgakilas, Bircan Günbulut, Kıvanç Güngör, Asım Güzelbey, Can Hekim, Farah Huzair, Sabit Kimyon, Ümit Karakaş, Biaoyang Lin, Adrián LLerena, Collen Masimirembwa, Ruth McNally, Alper Mete, Peşvin Sancar, Sanjeeva Srivastava, Lotte Steuten, Oylum Tanrıöver, David Tyfield, Volkan Töre, Deniz Vuruşkan, Wei Wang, Louise Warnich, Ambroise Wonkam, Yusuf Yıldırım, İsmet Yılmaz, Ahmet Sınav, and Nezih Hekim. ...
28-norlup-20(29)-en-3beta-hydroxy-17beta-hydroperoxide: antiproliferative triterpene from leaves of Melaleuca ericifolia; structure in first source
chemBlink provides information about CAS # 1338221-87-6, (3alpha,17beta)-4-Chloro-17-methylandrosta-1,4-diene-3,17-diol, molecular formula: C20H29ClO2.
The problem of global contamination from uranium (U) is a difficult task. The present investigation was aimed to study the possibilities of using prostate tissue as a biological material for global environmental monitoring of U. The U content in non-hypertrophic prostate of apparently healthy 64 residents of uncontaminated territory was measured by instrumental neutron activation analysis and inductively coupled plasma mass spectrometry. Mean values (M  SΕΜ) for the mass fraction of U in prostate of all subjects taken together was 0.0049 ± 0.0014 mg/kg of dry tissue. In order to estimate the effect of age on the investigated parameter we used three age groups: 13-20 years, 21-40 years, and 41-60 year. Mean values (M  SΕΜ) for the mass fraction of U (mg/kg of dry tissue) in age groups were as follows: 0.0023 ± 0.0007, 0.0021 ± 0.0005, and 0.0077 ± 0.0026, respectively. For the first time statistically significant (p ï‚£ 0.05, t- test) and exponential increase of the U content in
Excessive iron intake can also cause problems, as it is stored in the body. Too much iron in the tissues and organs leads to the production of free radicals and increases the need for vitamin E. There is a differentiation between plant and animal sources of iron. In animal sources, iron is often attached to proteins called haeme proteins, and referred to as haeme iron. In plant sources, iron is not attached to haeme proteins, and is classified as non-haeme iron. Haeme iron is typically absorbed at a rate of 7-35%, and non-haeme iron at a rate of 2-20%. Good food sources of iron include: - haeme iron: liver, red meat, shellfish, egg yolks - non-heame iron: legumes (lentils, beans, chickpeas), dark leafy greens (spinach, swiss chard), dried fruit (prunes, apricots) Vitamin C can increase the absorption of iron by as much as 30%, so aim to include foods rich in this essential nutrient if you are iron deficient. Sources: Prescription for nutritional healing. 4th edition. Phyllis A. Balch, CNC & ...
Testosterone modulates seizure susceptibility, but the underlying mechanisms are obscure. Recently, we demonstrated that testosterone affects seizure activity via its conversion to neurosteroids in the brain. Androstanediol (5α-androstan-3α,17β-diol) is an endogenous neurosteroid synthesized from testosterone. However, the molecular mechanism underlying the seizure protection activity of androstanediol remains unclear. Here we show that androstanediol has positive allosteric activity as a GABAA receptor modulator. In whole-cell recordings from acutely dissociated hippocampus CA1 pyramidal cells, androstanediol (but not its 3β-epimer) produced a concentration-dependent enhancement of GABA-activated currents (EC50, 5-μM). At 1μM, androstanediol produced a 50% potentiation of GABA responses. In the absence of GABA, androstanediol has moderate direct effects on GABAA receptor-mediated currents at high concentrations (10-μM). Systemic doses of androstanediol (5-100 mg/kg), but not its ...
3α-androstanediol glucuronide is a product of androgens degradation, particularly by intracellular reduction of DHT. Its determination is used in management of diseases with excessive androgen production. It reflects skin androgen activity, which is dependent on the presence of 5α-reductase enzyme, converting testosterone to DHT. Accordingly, the measurement of 3α-androstanediol glucuronide is an indirect way of testing DHT and 5α-reductase activity.. ...
Muscles are more relaxed, including your bowel, so food doesnt move through the body so quickly, causing a delightful trio of constipation, bloating and wind. Also each trimester, feelings of pregnant woman changes, you may be fraught with weepiness, fatigue. Her heart defect was diagnosed within few months after her birth. I couldve killed my husband had I been able to roll out the bed. Go to a class about childbirth, especially if you havent been pregnant before. Bronchitis is a condition characterized by inflammation of the bronchioles. Studies suggest after heavy period pregnancy about 40 of cases of the cancer are linked to obesity. LOL I think Id fall over if it did. Download the What To Expect app for week-by-week updates, news, tips from experts and more. Just as after heavy period pregnancy ok to sample the flavor of your labor and then accept a second surgery. It is associated with the increasing level of progesterone and other things including increase in blood production after ...
to this approach. Patients may require frequent blood and platelet transfusion support which is expensive and inconvenient. Life-threatening ... agents can provide a new therapeutic option for enhancing blood production. In this review, we discuss these recent results and ongoing .... Research Article last updated 06/20/2013 - 10:13am.. ...
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We have formulated and demonstrated a novel, superior, polymer system, OSTE, and its manufacturing platform, which is based on the mixture of three monomers: thiols, -enes and epoxies. The uniqueness of the OSTE approach stems from the curing in two distinct steps: after the first cure, an intermediate polymer is formed which is ideally suited for surface modifications and bonding; after the second cure we obtain an inert and robust polymer. The talk will introduce the novel polymer, and show functional medical and microfluidic components that demonstrate the unique opportunities that OSTE provides in terms of mechanical properties, surface modification and bonding. ...
Nå skal jeg ikke gå i dybden på det lyriske men bare fastslå at det er heftige saker som er under lupen, og det spares ikke på kruttet og det er samfunnsrefsing i bøtter og spann. Jones er krystallklar på at mye av livet på planeten Tellus i stor grad er dysfunksjonelt. Enig eller uenig i det verbale så kan likevel de fleste enes om at Census Of Hallucinations har et sound som ikke akkurat er hverdagskost i vår forunderlig musikkverden. Ja sågar så er soundet på grensen til unikt, og her er stemmen til Tim Jones et viktig element. Den er definitivt unik, og når han så bakkes opp av Terri~B og Maxine Marten sine drømmeliknende surrealistiske stemmer, da er vokaldepartementet noe lytteren biter seg merke i! Noe som utmerket vel kan føre til at lytteren blir smått fascinert og forført. Omtale Jones er en utmerket gitarist, men i HoC konteksten har han konsentrert seg om det vokale, lyrikken og låtsnekringa. Veteranen John Simms som er ny i HoC og styrer med gitarene og mannen ...
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
Many people spend lots of money each year on promoting mens health. They are spending mostly on increasing muscle, strength, muscular hardness, energy, and sensual performance. Cutting Edge Natural Testosterone- primasurge is the premier non-proprietary blend and science-based testosterone booster on the herbal market. It has been formulated by using the most effective ingredients of the world. This dose is most efficacious to boost testosterone levels. It helps you in many ways such as, to chisel physique, energize mind, and boost strength. If you want to get the best results, you should not settle under-dosed generic formulas that simply do not work.. Amazon has several brands it the market. Among the brands 125mg of Patented Primavie® Shilajit is great. It has been standardized to have more than 50% fluvic acid and equivalents. This is the best natural testosterone booster. This is rare products in the market. This rare compound has been shown in clinical research to pointedly increase ...
Dihydrotestosterone gets a mixed rep. This guide will go over everything you need to know about DHT and whether using DHT blockers is a good idea.
Susto-Test Depot Ingredients: 17a-methyl-androst-1 4-diene-3-17b-diol 100 mg Estra-4, 9-diene-3, 17-dione 75 mg 6,7 dihydroxybergamottin (DHB) 155 mg
CAS: 15262-86-9 MF: C25H38O3 MW: 386.57 EINECS: 239-307-1 Synonyms: 17beta-hydroxyandrost-4-ene-3-one 4-methylvalerate;4-ANDROSTEN-17-BETA-OL-3-ONE ISOCAPROATE;4-ANDROSTEN-17BETA-OL-3-ONE ISOCAPRONATE;4-ANDROSTEN-17BETA-OL-3-ONE...
oids can live healthy life in later years. These medicines have tremendous benefits, if used in the right way and right time.. There are many innovations in the legal steroids market. These amazing muscle supplements are very powerful muscle building and fat burning pills.. However, the men on steroids who are abusing steroids are vulnerable to several side effects. Some of the signs of the young men steroids include quick weight gain with larger muscle mass, aggressiveness and bad attitude, jaundice / skin change, purple or red spots on the body, swelling of feet and lower legs, shaking or trembling, persistent body odors, and severe acne breakouts with oily skin.. While the side effects that the men on steroids may experience may include testicular shrinkage. Powerlessness, hair loss, sterility, development of breasts or nipples. Furthermore, urinary problems, increased size of prostate gland, and reduced sperm count.. ...
University of Rochester Medical Center researchers have discovered new links between leukemia cells and cells involved in bone formation, offering a fresh perspective on how the blood cancer progresses and raising the possibility that therapies for bone disorders could help in the treatment of leukemia.. The research, led by graduate student Benjamin J. Frisch in the James P. Wilmot Cancer Center laboratory of corresponding author Laura M. Calvi, M.D., is featured in the journal Blood. It is accompanied by an editorial - "Bad to the Bone" -- written by another leading investigator in the field, Steven W. Lane, M.D., of Queensland Institute of Medical Research. Lane says that the URMC´s unexpected laboratory finding provokes new clinical questions, such as whether screening for osteoporosis could provide any useful information for how to manage acute leukemia in newly diagnosed patients.. Leukemia is a devastating disease that results in the disruption of normal blood production. Blood stem ...
Buy high quality 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 981-34-0 from toronto research chemicals Inc.
LY 191704 is a 5α-reductase type 1 inhibitor that has potential for the treatment of disorders associated with the overproduction of dihydrotestosterone such as
Treatment for Cortisone Reductase Deficiency. Find Doctors Near You, Book Appointment, Consult Online, View Doctor Fees, Address, Phone Numbers and Reviews. Doctors for Cortisone Reductase Deficiency | Lybrate
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The ability of the nonglucocorticoid 21-aminosteroid U74006F, a potent inhibitor of iron-dependent lipid peroxidation, to antagonize progressive brain hypoperfusion after a 5-minute episode of global brain ischemia was examined in alpha-chloralose-anesthetized cats. Immediately after a 5-minute episode of near-total tourniquet-induced brain ischemia, cortical blood flow returned to normal or above normal. Thereafter, cortical blood flow fell progressively to a level 71.7% below normal by 3 hours after ischemia. In contrast, in cats that received 1 mg/kg i.v. U74006F 15 minutes after the ischemic episode, cortical blood flow remained significantly greater than that seen in vehicle-treated cats. At 3 hours, cortical blood flow had declined by only 45.7% (p less than 0.04 compared with vehicle). In addition, U74006F treatment significantly improved postischemic maintenance of blood pressure and recovery of somatosensory evoked potentials and reduced postischemic arterial blood acidosis. U74006F had ...
Looking for online definition of dihydrotestosterone in the Medical Dictionary? dihydrotestosterone explanation free. What is dihydrotestosterone? Meaning of dihydrotestosterone medical term. What does dihydrotestosterone mean?
0035] The additional active agent is preferably a hematopoietic growth factor, a cytokine, an anti-cancer agent, an antibiotic, an anti-fungal, an anti-inflammatory, an immunosuppressive agent such as a cyclosporin, conventional therapy for MDS, or other chemotherapeutic agent found for example in the Physicians Desk Reference. Preferred anti-cancer or cancer chemotherapeutics are apoptosis inducing agents, topoisomerase inhibitors, anti-angiogenesis compounds, microtubule stabilizing agents, alkylating agents and other known conventional cancer chemotherapy. Most preferred additional active agents are those capable of affecting or improving blood production. The active agents can be large molecules (e.g., proteins) or small molecules (e.g., synthetic inorganic, organometallic, or organic molecules). The examples of specific additional active agent include, but are not limited to, gemtuzamab ozogamicin, etanercept (Enbrel®), imatinib (Glivec®), anti-TNF-α antibodies, infliximab (Remicade®), ...
It may be a resounding yes or no. Medical studies show that women are not the only ones who experience menopause, men does too. The term is referred to as male menopause commonly known as andropause. Viropause is another term for male menopause. This is described to be the cause of low testosterone levels. Others view it as an end to first adulthood and an indication to begin second adulthood. Some individuals on the other hand view andropause in a sexual manner, wherein it signifies deterioration of sexual desires and performance.. Men may find this fact alarming. Perhaps then, they will start to realize and later on comprehend how it is like to have drastic hormonal change. Menopause for women has distinct and defined symptoms such as stop of menstrual cycle, hot flashes which is evident on the face, chest and neck, too much perspiration, dryness in the vagina, throbbing heartbeat, body aches, itching skin, the growth of hair increases specifically on face but growth of hair decreases on ...
CHAPTER 1 Aggregation of receptors for IgE (Fc RI) causes mast cells and basophils to release preformed contents of granules, including histamine and a variety of enzymes. This process, called degranulation plays a central role in allergic reactions. Methods to study this process are to create multivalent ligands which can interact with the receptors and, in turn, lead to aggregation of the receptors. We prepared a series of fluorophore-labeled divalent and trivalent antigens to study the degranulation of mast cells. Trivalent antigens proved to be much better stimulators for degranulation of mast cells than divalent antigens. These results indicate that aggregates formed by trivalent antigens are more complicated than those of divalent antigens. CHAPTER 2 Membrane-active antibiotics include antimicrobial peptides (AMPs) and a class of amphiphilic steroids termed ceragenins. Recent studies of membrane-active antibiotics show that cationic, facially amphiphilic molecules could disrupt bacterial membranes
Product Description Product Description Sex Hormone Powder Androgen 1- DHEA /1-Androsterone Safe Shipping Quick details 1-DHEA / 1-Androsterone Alias:Androsta-1-ene-3b-ol,17-one;Androstene-3b-ol,17-one;1-Dehydropiandrosterone CAS register number:76822-24-7 Assay:99% EINECS No.:76822-24-7 Appearance: white or off white crystalline powder Related Substances: Pharmaceutical Grade Storage: Shading, confined preservation Description: Items Tested Specification Result Characters White or almost white crystalline powder Confirms Assay (HPLC) 99.0--101.0%…
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Synonyms: TESTOSTERONE PROPIONATE;TESTOSTERON 17-PROPIONATE;TESTOSTERONE 17-PROPIONATE;PROPIONIC ACID (8R,9S,10R,13S,14S,17S)-10,13-DIMETHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL ESTER;17-(1-oxopropoxy)-(17-beta)-androst-4-en-3-on;17-[(1-Oxopropanoyl)oxy]androst-4-en-3-one;3-Oxoandrost-4-en-17-yl propionate;Agovirin ...
DNA intercalating molecules are promising anticancer agents. Polycyclic aromatic molecules such as ellipticine intercalate into double-stranded DNA and affect major physiological functions. In the pre
Weapons Of Mass Feminization Written By: Jennie Ann Freiman MD Weapons Of Mass Feminization If youve ever wondered where all the alpha males have gone, the interaction between chemistry and biology may offer a clue.
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Hematopoiesis during embryogenesis and adult life has been extensively studied in several vertebrate models. The zebrafish (Danio rerio) has recently provided a powerful genetic system to further dissect the molecular pathways of hematopoiesis. Large-scale genetic screens utilizing the zebrafish have identified blood mutants with defects in mesoderm patterning, hematopoietic stem cell generation and maintenance, hematopoietic progenitor cell proliferation and differentiation, and erythoid differentiation. Cloning of the mutations has revealed both known and novel genes required for blood production, and served to underscore the strength of the zebrafish as a hematopoietic model. Continued study of zebrafish hematopoietic mutants offers an exciting venue to investigate hematopoiesis during vertebrate ontogeny, as well as to elucidate therapeutics for human blood diseases ...
Sleeping loads the first day tignten two is pretty frequent. Breathing exercises, similar to those you exerciwe in your pre-natal classes, can do a lot the identical thing. Kicks from an lively baby might cause sharp pains, and lower backaches are common. It is more durable to predict ovulation in girls with irregular cycles, but it surely normally occurs 12 to 16 days before the start of the womans next period. Hello Wellencia, having an unprotected intercourse exdrcise lead to being pregnant. It is because as your baby grows exxercise uterus (womb) tends to tilt to the suitable (Aguilera et al 2005). Hello rubyrose - take a look at our fetility part. Camann points out that with your bodys elevated blood quantity throughout being pregnant, your physique may need pregnancy rash hip sodium to pump up blood production. Different foods that you just usually love might develop into your least favourite meals. When you do lie down, sleep with your head slightly elevated. What a take a look at gives ...
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The cyclic trithiocarbonates 1,3-dithioIane-2-thione (4) and 1,3-dithiole-2-thione (9) in 1,2-dichloroethane and MeCN, respectively, react with alkyl- and phenyl-substituted oxiranes 2 in the presence of Lewis acids to give 1-oxa-4,6,9-trithiaspiro[4.4]nonanes 5 and 6 (Scheme 2) and 1-oxa-4,6,9-trithiaspiro[4.4]non-7-enes 10 and 11 (Scheme 3), respectively. The reactions proceed regioselectively yielding 2-alky1 (5,10) and 3-phenyl derivatives (6, 11) as the main products. From the reaction of 4 and 2-phenyloxirane (2e) with TiCl4, 2-phenyl-1,4,6,9-tetrathiaspiro[4.4]nonane (7) is isolated as a minor product. The molecular structures of 5a, 6e, and 7 are established by X-ray crystallography. ...
Ghoussaini, Maya, Fletcher, Olivia, Michailidou, Kyriaki, Turnbull, Clare, Schmidt, Marjanka K., Dicks, Ed, Dennis, Joe, Wang, Qin, Humphreys, Manjeet K., Luccarini, Craig, Baynes, Caroline, Conroy, Don, Maranian, Melanie, Ahmed, Shahana, Driver, Kristy, Johnson, Nichola, Orr, Nicholas, Dos Santos Silva, Isabel, Waisfisz, Quinten, Meijers-Heijboer, Hanne, Uitterlinden, Andre G., Rivadeneira, Fernando, Hall , Per, Czene, Kamila, Irwanto, Astrid, Liu, Jianjun, Nevanlinna, Heli, Aittomaki, Kristiina, Blomqvist, Carl, Meindl, Alfons, Schmutzler, Rita K., Muller-Myhsok, Bertram, Lichtner, Peter, Chang-Claude, Jenny, Hein, Rebecca, Nickels, Stefan, Flesch-Janys, Dieter, Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel, Bui, Minh, Hopper, John L., Apicella, Carmel, Park, Daniel J., Southey , Melissa C., Hunter, David J., Channock, Stephen J., Broeks, Annegien, Verhoef, Senno, Hogervorst, Frans B.L., Fasching, Peter A., Lux, Michael P., Beckmann, Matthias W., Ekici, Arif B., Sawyer, Elinor, Tomlinson, ...
Enes Elvin G l. Who are the main actors of cardiac device follow-up? Analysis of the super follow-up study. Anatol J Cardiol. 2017; 18(5): 374- ...
The peculiar i t ies of re ta ining BSP were invest igated in hepatic diseases, especially for the purpose to s tudy the pathogenesis of const i tu t ional hyperbi l i rubinemia. Methods and Subjects: Total (T), free (F) and conjugated (C) BSP levels were examined by chromatography before and 15 minutes a f te r in t ravenous inject ion of dehydrocholic acid (DHC) of l g , which were performed immediately a f te r collecting a blood sample at 45 minutes in routine BSP test . The subjects included 16 l iver cirrhosis, 18 hepat i t is , 22 obstruct ive jaundice and 4 const i tut ional hyperbi l i rubinemia, diagnosed by biopsy, operat ion or autopsy. Results: a) In l iver cirrhosis, F-BSP decreased, but C-BSP showed li t t le changes af ter DHC injection. b) In hepat i t is , T-BSP and F-BSP showed no uni form changes. Elevat ion of C-BSP was observed in th ree cases with pers is tent hepat i t i s . c) In ex t rahepat ic obstruct ive jaundice, depression of F-BSP and elevat ion of C-BSP were observed af
Applied Nutriceuticals IGF-2 provides the mechanisms to trigger exponential increases in both serum testosterone and human growth hormone levels. IGF-2 is enzymatically converted to 11-oxa-5 alpha-androstane-3,17-dione, a portion of which is then converted to testosterone through the testes. Increased levels of testosterone signals the muscles to increase protein synthesis and nitrogen retention, leading to greater strength, size, and recovery.
Products Testosterone Series Clostebol acetate/4-Chlorotestosterone Acetate Clostebol acetate (Steroids) Alias: 4-chlorotestosterone acetate; 4-chloroandrost-4-ene-17beta-ol-3-one acetate;Turinabol CAS NO.: 855-19-6 EINECS: 212-720-4 Assay: 98%...
This paper argues that the feminisation of migration has heightened the awareness of human trafficking, yet the feminisation of poverty is a social concept that is yet to be fully understood within the context of human trafficking. The false notion of
The local implications of large-scale land acquisitions (LSLAs), commonly referred to as land grabs, are at the center of an exponential production of scientific literature that only seldom focuses...
Wiem napewno, test prop eq masteron cycle że niebyłoby to zbyt test prop eq masteron cycle drostanolone and androstane wysoko. Fire fungsi drostanolone By Permit Only Notice is hereby given pursuant to Section 22 of masteron npp stack the Forest
b. Endogenous** AAS when administered exogenously: androstenediol (androst-5-ene-3 ,17 -diol); androstenedione (androst-4-ene-3,17-dione); dihydrotestosterone (17 -hydroxy-5 -androstan-3-one) ; prasterone (dehydroepiandrosterone, DHEA); testosterone and the following metabolites and isomers: 5 -androstane-3 ,17 -diol; 5 -androstane-3 ,17 -diol; 5 -androstane-3 ,17 -diol; 5 -androstane-3 ,17 -diol; androst-4-ene-3 ,17 -diol; androst-4-ene-3 ,17 -diol; androst-4-ene-3 ,17 -diol; androst-5-ene-3 ,17 -diol; androst-5-ene-3 ,17 -diol; androst-5-ene-3 ,17 -diol; 4-androstenediol (androst-4-ene-3 ,17 -diol); 5-androstenedione (androst-5-ene-3,17-dione); epi-dihydrotestosterone; epitestosterone; 3 -hydroxy-5 -androstan-17-one; 3 -hydroxy-5 -androstan-17-one; 19-norandrosterone; 19-noretiocholanolone. [Comment to class S1.1b: Where an anabolic androgenic steroid is capable of being produced endogenously, a Sample will be deemed to contain such Prohibited Substance and an Adverse Analytical Finding will ...
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone ...
I bet the residents of Dish dont agree that natural gas is the "clean" source of energy of the future. They recently hired a company to study the air quality in their town after numerous complaints about odor and noise. Wolf Eagle Environmental, a company located in Flower Mound, did the study and their findings were shocking. They found high levels of 15 chemicals at five of seven test sites. These chemicals included benzene, xylene, naphthalene and carbon disulfide. The levels of these chemicals were 10 times the recommended level for short-term exposure. Some were high enough to be considered an immediate danger. Below is a little info from the OSHA site on these chemicals.. Benzene: http://www.osha.gov/SLTC/benzene/ With exposures from less than five years to more than 30 years, individuals have developed, and died from, leukemia. Long-term exposure may affect bone marrow and blood production. Short-term exposure to high levels of benzene can cause drowsiness, dizziness, unconsciousness, ...
Your baby will measure between 18-22 inches at birth. The core muscles can help to prevent falls and injuries that are more common during pregnancy and make delivery shorter and easier. Usually, the first day of the last menstrual period commences the nine months duration of pregnancy. This ovum would then travel through the Fallopian tubes dental anesthesia and pregnancy to the uterus. so tiny. Ask family members or friends dentql help prrgnancy housework, cooking, and shopping. Blood on toothbrush - Gross I know, but your body ramps up blood production while preggo which makes even healthy gums much more susceptible to bleeding. The embryo will have a very simply circulatory system and heart and will start to develop buds that will eventually grow into arms and legs. Females have a pair of ovaries located on each side of the uterus. Although I havent done dental anesthesia and pregnancy blood test, but I am sure the baby is there. If youre slipping away to visit the ladies room all night, ...
Ceragenix Pharmaceuticals, Inc. is a biopharmaceutical company headquartered in Denver, Colorado that develops prescription therapies based on a platform of proprietary surface active technologies-skin Barrier Repair Technology (BRT) and Cerageninis, a new class of broad spectrum anti-infectives. The company discovers, develops and commercializes anti-infective drugs based on its proprietary class of compounds, Ceragenins. Active against a range of gram positive and gram negative bacteria, these agents are being developed as anti-infective medical device coatings and as therapeutics for antibiotic-resistant organisms. Ceragenix developed EpiCeram. It is a topical non-steroidal skin care cream based on the research of Peter Elias for the treatment of atopic dermatitis (eczema). Ceragenixs second platform technology addresses multidrug resistant bacterial and viral infections. The anti-infective technology is based on the research of Dr. Paul B. Savage, Professor and Associate Chair of ...
Hormone information provided by The Hormone Help Center is clear, practical information about women s common hormone problems including alopecia, acne, PMS, (Pre-menstrual syndrome), mood swings, menstrual disorders, bleeding, menstrual cramps, irregular periods, acne rosacea, loss of sex drive, breast pain, female pain, pelvic pain, fluid retention, premature ovarian failure, and female endocrinology issues.
5$\alpha$-Cholest-8(14)-en-3$\beta$-ol-15-one is a potent inhibitor of cholesterol biosynthesis which has been found to have significant hypocholesterolemic action upon oral administration to rodents and nonhuman primates. The metabolism of (2,4-$\sp3$H) 5$\alpha$-cholest-8(14)-3n-3$\beta$-ol-15-one was studied in Chinese hamster ovary (CHO-K1) cells. The incorporation of the labeled 15-ketosterol into the cells was linear with respect to sterol concentration in the medium over the range of concentrations studied and was higher than the uptake of cholesterol. The results of detailed analyses of the lipids recovered from the cells after 6 hours of incubation with the (2,4-$\sp3$H) -15-ketosterol indicated that most of the $\sp3$H was associated with the free 15-ketosterol. Considerably smaller amounts of $\sp3$H were associated with esters of the 15-ketosterol. No conversion of the 15-ketosterol to cholesterol or other C$\sb{27}$ monohydroxysterols was observed. The labeled material with the ...
Dianabol is one of the most common oral steroids called Methandrostenolone. A derivative of testosterone, Dianabol is one of the most popular steroids and exhibits strong anabolic and moderate androgenic properties. Its easy usage and effectiveness is what makes this steroid widely accepted. Its chemical name is 17a-methyl-17b-hydroxy-1,4-androstadien-3-one 1-Dehydro-17 a methyltestosterone.. Dianabol, or D-bol as it is commonly addressed, is widely used because of its remarkable ability to build muscle strength in a relatively very short span of time. It also possesses a multifaceted approach in building the muscles without causing and loss of weight. The Methandrostenolone contained in Dianabol is its most active ingredient and acts in an ergogenic manner when orally administered.. Most common users of D-bol are athletes and particularly bodybuilders seeking maximum muscle mass within minimum time limits. Dianabol contains a powerful anabolic agent which upon entering the body, increases the ...
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The feminization of poverty is a term that reflects that changes that are being seen in households that are in poverty. Specifically, it is a reference to the increase of poverty in households that are headed by women compared to households headed by men or by couples. In looking at poverty on a global scale,…
There are many different things that can cause anemia. You can rule out different forms of anemia through most blood testing. Given the conditions you have and the medications listed, any of those can be contributing to anemia. Naproxen (a non-steroidal anti-inflammatory: NSAID) can cause increased bleeding time and bleeding which can lead to anemia. NSAIDs are often associated with GI bleeding if taken for long periods of time. Methotrexate is an immunosuppressant and has a labeled side effect of aplastic anemia, which is caused from suppression of the bone marrow leading to a decrease in the production of red blood cells. Plaquenil is also associated with aplastic anemia through bone marrow suppression.. In regards to autoimmune diseases - anemia of chronic disease is really common in those with rheumatoid arthritis. Inflammation in chronic inflammatory conditions such as rheumatoid arthritis and many other autoimmune diseases can affect blood production in a number of different ways. Many ...

List of androstanes - WikipediaList of androstanes - Wikipedia

This is a list of androstanes, or androstane derivatives. Androstanol 3α,5α-Androstanol (5α-androstan-3α-ol) - an endogenous ...
more infohttps://en.wikipedia.org/wiki/List_of_androstanes

Androstanes - Phenotypes | CTDAndrostanes - Phenotypes | CTD

pronamide results in increased androgen metabolic process] which results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta ...
more infohttp://ctdbase.org/detail.go?type=chem&acc=D000731&view=phenotype

Androstenediol - WikipediaAndrostenediol - Wikipedia

Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
more infohttps://en.wikipedia.org/wiki/5-Androstenediol

Pregnenolone - WikipediaPregnenolone - Wikipedia

Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
more infohttps://en.wikipedia.org/wiki/Pregnenolone

RCSB PDB - ASD Ligand Summary PageRCSB PDB - ASD Ligand Summary Page

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
more infohttp://www.rcsb.org/ligand/ASD

steroid : Wikis (The Full Wiki)steroid : Wikis (The Full Wiki)

Androstanes testosterone 19 Estranes estradiol 18 See also. *Batrachotoxin *List of steroid abbreviations ...
more infohttp://www.thefullwiki.org/steroid

CELLULOSE CAPSULES AND METHODS FOR MAKING THEM - UNIVERSITY OF IOWA RESEARCH FOUNDATIONCELLULOSE CAPSULES AND METHODS FOR MAKING THEM - UNIVERSITY OF IOWA RESEARCH FOUNDATION

Androstanes as androgen receptor modulators. November, 2004. Wang. 20080161314. Novel Diazabicyclic Aryl Derivatives and Their ...
more infohttp://www.freepatentsonline.com/y2012/0277323.html

Patent US5795880 - Method and composition for treating obesity and related disorders in animals ... - Google PatentsPatent US5795880 - Method and composition for treating obesity and related disorders in animals ... - Google Patents

16-substituted androstanes and 16-substituted androstenes. US5006517 *. Jul 24, 1989. Apr 9, 1991. Progenics, Inc.. Treatment ... Derivatives of DHEA, such as 16-substituted androstanes and 16-substituted androstenes, are described in U.S. Pat. No. ... is selected from the group consisting of 16-substituted androstanes, 16-substituted androstenes, 17 hydroxy-steroids, α-HET, β- ...
more infohttp://www.google.com/patents/US5795880?dq=5,815,794

Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR.Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR.

CoMFA models for androstanes. A 5?-Androstan-3?-ol (pIC50?=?6.1) shown with the steric component of the CoMFA model. Green ... Among the androstanes, 6 out of 11 compounds were predicted correctly as activators and 9 out of 14 compounds were classified ... CoMSIA models for androstanes. A - 17?-dihydroandrosterone (pIC50?=?5.38) with the steric component of the CoMSIA model. Blue ... A. 4D-QSAR for androstanes showing the active conformation of 5?-Androstan-3?-ol, B 4D-QSAR for pregnanes showing the active ...
more infohttp://www.biomedsearch.com/nih/Challenges-predicting-ligand-receptor-interactions/20011107.html

Testosterone / testosterone NDA 076744 global drug patent coverage, generic alternatives and manufacturersTestosterone / testosterone NDA 076744 global drug patent coverage, generic alternatives and manufacturers

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
more infohttps://www.drugpatentwatch.com/p/NDA/076744

US20070141933A1 - Aqueous polyolefin dispersions for textile impregnation 
        - Google PatentsUS20070141933A1 - Aqueous polyolefin dispersions for textile impregnation - Google Patents

19-alkyl androstanes GB1182669A (en) * 1966-07-28. 1970-03-04. Foss Mfg Company Inc. Shoe stiffeners ...
more infohttps://patents.google.com/patent/US20070141933?oq=flatulence

Sciencemadness Discussion Board - The Short Questions Thread (4) - Powered by XMB 1.9.11Sciencemadness Discussion Board - The Short Questions Thread (4) - Powered by XMB 1.9.11

Bohumil, P., Unsaturated androstanes. Czech. 127,564, 1968;. Bohumil P. Chem Abstr 1969;70:68637.. Anyone have any idea what ... Bohumil, P., Unsaturated androstanes. Czech. 127,564, 1968;. Bohumil P. Chem Abstr 1969;70:68637.. Anyone have any idea what ...
more infohttp://www.sciencemadness.org/talk/viewthread.php?tid=25055&page=87

17β-Hydroxysteroid dehydrogenase - Wikipedia17β-Hydroxysteroid dehydrogenase - Wikipedia

Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion ...
more infohttps://en.m.wikipedia.org/wiki/17%CE%B2-hydroxysteroid_dehydrogenase

Publications - Uni OldenburgPublications - Uni Oldenburg

Norden S., Bender M., Rullkötter J., Christoffers J., 2011. Androstanes with modified carbon skeletons. Eur. J. Org. Chem. 4543 ...
more infohttps://www.icbm.de/en/organic-geochemistry-group/publications/

SteroidsSteroids

ANDROSTANES AND PREGNANES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR. Methods, compositions, and compounds for modulating the ...
more infohttp://www.sumobrain.com/ICL-C07J5-p4.html

US5554603A - Orally active derivatives of 1,3,5(10)-estratriene 
        - Google PatentsUS5554603A - Orally active derivatives of 1,3,5(10)-estratriene - Google Patents

19-Oxygenated-5α-androstanes for the enhancement of libido US4966897A (en) 1990-10-30. 4-substituted 17β-(cyclopropyloxy) ...
more infohttps://patents.google.com/patent/US5554603A/en

17β-Hydroxysteroid dehydrogenase - Wikipedia17β-Hydroxysteroid dehydrogenase - Wikipedia

Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion ...
more infohttps://en.wikipedia.org/wiki/17%CE%B2-Hydroxysteroid_dehydrogenase

Phenobarbital Meets Phosphorylation of Nuclear Receptors | Drug Metabolism & DispositionPhenobarbital Meets Phosphorylation of Nuclear Receptors | Drug Metabolism & Disposition

Later, androstanes were found to repress constitutive activity of CAR in cell-based assays, which became the basis of "CAR" to ... Although androstanes are useful to identify CAR activators in cell-based reactivation assays (Sueyoshi et al., 1999), there is ... no biologic significance to CAR being repressed by androstanes. In addition, an androstane also activates the pregnane X ...
more infohttp://dmd.aspetjournals.org/content/45/5/532?ijkey=0121204ebb65327f2874c90e1287961eede05620&keytype2=tf_ipsecsha

Fecal progesterone, estrogen, and androgen metabolites for noninvasive monitoring of reproductive function in the female Indian...Fecal progesterone, estrogen, and androgen metabolites for noninvasive monitoring of reproductive function in the female Indian...

Pregnane metabolites were reliable indicators of the corpus luteum and pregnancy, whereas fecal 17-oxo-androstanes and ... Progesterone metabolites were also reliable indicators of pregnancy, whereas 17-oxo-androstanes and estrogens were basal ... 17-oxo-androstanes), and total estrogens. Androgens and estrogens were found to be reliable indicators of the follicular phase ... and several 17-oxo-androstanes, 20 alpha-OH-pregnanes, and 20-oxo-pregnanes. Concentrations of a peak with an elution profile ...
more infohttp://www.biomedsearch.com/nih/Fecal-progesterone-estrogen-androgen-metabolites/11017777.html

Golexanolone - Umecrine Cognition - AdisInsightGolexanolone - Umecrine Cognition - AdisInsight

Class Alkynes; Androstanes; Hepatoprotectants; Imines; Neuroprotectants; Small molecules * Mechanism of Action GABA-A receptor ...
more infohttps://adisinsight.springer.com/drugs/800049924?error=cookies_not_supported&code=123e1d2f-0895-452a-8d55-f54f1f350109

Bruce E Dale - Publications
     - MSU ScholarsBruce E Dale - Publications - MSU Scholars

Parreiras, L. S. , Breuer, R. J. , Narasimhan, R. A. , Higbee, A. J. , La Reau, A. , Tremaine, M. , Qin, L. , Willis, L. B. , Bice, B. D. , Bonfert, B. L. , Pinhancos, R. C. , Balloon, A. J. , Uppugundla, N. , Liu, T. , Li, C. , Tanjore, D. , Ong, I. M. , Li, H. , Pohlmann, E. L. , Serate, J. & 12 others Withers, S. T., Simmons, B. A., Hodge, D. B., Westphall, M. S., Coon, J. J., Dale, B. E., Balan, V., Keating, D. H., Zhang, Y., Landick, R., Gasch, A. P. & Sato, T. K. Sep 15 2014 In : PLoS One. 9, 9, e107499. Research output: Contribution to journal › Article ...
more infohttps://scholars.opb.msu.edu/en/persons/bruce-e-dale-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

GlucocorticoidGlucocorticoid

Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
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  • HPLC separation of immunoreactive fecal metabolites indicated the presence of estrone, estradiol-17beta, and several 17-oxo-androstanes, 20 alpha-OH-pregnanes, and 20-oxo-pregnanes. (biomedsearch.com)