Androstanes: The family of steroids from which the androgens are derived.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Cell Line, Tumor: A cell line derived from cultured tumor cells.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Appetite Depressants: Agents that are used to suppress appetite.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Dehydroepiandrosterone Sulfate: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.Weight Gain: Increase in BODY WEIGHT over existing weight.Body Composition: The relative amounts of various components in the body, such as percentage of body fat.Drug and Narcotic Control: Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Legislation, Drug: Laws concerned with manufacturing, dispensing, and marketing of drugs.Anabolic Agents: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Designer Drugs: Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.Writing: The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Xenobiotics: Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.Metabolic Detoxication, Drug: Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.Receptors, Cytoplasmic and Nuclear: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.Cytochrome P-450 CYP3A: A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.Pregnenolone Carbonitrile: A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Androstenols: Unsaturated androstanes which are substituted with one or more hydroxyl groups in any position in the ring system.Logic: The science that investigates the principles governing correct or reliable inference and deals with the canons and criteria of validity in thought and demonstration. This system of reasoning is applicable to any branch of knowledge or study. (Random House Unabridged Dictionary, 2d ed & Sippl, Computer Dictionary, 4th ed)Psychology, Experimental: The branch of psychology which seeks to learn more about the fundamental causes of behavior by studying various psychologic phenomena in controlled experimental situations.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Gene Regulatory Networks: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.Adosterol: A sterol usually substituted with radioactive iodine. It is an adrenal cortex scanning agent with demonstrated high adrenal concentration and superior adrenal imaging.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.Chrysenes: 1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.Gene Products, tat: Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)HIV-2: An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition. It shares serologic reactivity and sequence homology with the simian Lentivirus SIMIAN IMMUNODEFICIENCY VIRUS and infects only T4-lymphocytes expressing the CD4 phenotypic marker.Androstenediol: An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).Hydroxysteroid Dehydrogenases: Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Estranes: A group of compounds forming the nucleus of the estrogenic steroid family.Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.Estriol: A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.3-Hydroxysteroid Dehydrogenases: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Names: Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.United States

Transfer of the 1-pro-R and the 1-pro-S hydrogen atoms of ethanol in metabolic reductions in vivo. (1/122)

The transfer of deuterium from [1 R-2H]ethanol and [1 S-2H]-ethanol to reduced metabolites of administered compounds was measured in female rats provided with bile fistulas. Administered cyclohexanone was reduced to cyclohexanol, and in this reduction hydrogen was transferred only from the 1-pro-R position of the ethanol. The deuterium content in the cyclohexanol was about 67% of that in the ethanol. In the reduction of the 17-oxo group in 3beta-hydroxy-5alpha-androstan-17-one, hydrogen was transferred both from the 1-pro-R position and the 1-pro-S position, resulting in degrees of labelling that were about 25% and 2%, respectively, of those in the specific positions of the ethanols. The 1-pro-R and 1-pro-S positions of ethanol contributed about 9% and 5%, respectively, of the 3beta hydrogen in lithocholic acid formed from 3-oxo-5beta-cholanoic acid. The results indicate that alcohol dehydrogenase and aldehyde dehydrogenase do not share a common pool of NAD, and that NADH formed during acetaldehyde oxidation is utilized for reductions in the cytosol to a smaller extent than the NADH formed in the alcohol dehydrogenase reaction. This result supports the concept that aldehyde oxidation is mainly an intramitochondrial process. The relatively extensive utilization of the 1-pro-S hydrogen of ethanol in the reduction of 3-oxo-5beta-cholanoic acid, that is probably NADPH-dependent, indicates that cytosolic NADPH may be produced from malate or isocitrate formed intramitochondrially.  (+info)

Induction of delta-aminolevulinic acid synthetase in isolated rat liver cells by steroids. (2/122)

The role of steroids in regulation of delta-aminolevulinic acid synthetase has been studied in isolated rat liver cell suspensions under conditions previously shown to support inducation of the enzyme by drugs. Addition of a variety of C-19 and C-21 steroids to cell suspensions resulted, after 4 to 6 hours of incubation, in 2- to 5-fold increase in the activity of delta-aminolevulinic acid synthetase as measured in liver cell homogenates. The increase was prevented by cycloheximide. The most active steroid inducers tested were pregnene or pregnane derivatives with keto or hydroxyl groups at C-3 and C-20; in particular a beta-hydroxyl group at C-20 enhanced activity. These C-21 steroids at optimal initial concentrations caused 3- to 5-fold induction over 4 hours. A number of C-19 androstene and androstane compounds caused 2- to 3-fold inducation over the same period. Hydrocortisone had no effect. For a variety of androstane and pregnane derivatives, inducation by 5alphaH steroids was as great as or greater than that by 5betaH compounds, in contrast to previous findings in chick embryo liver. Induction of delta-aminolevulinic acid synthetase by steroids in isolated liver cells was shown to be subject to feedback repression by hemin.  (+info)

Regulation and substrate specificity of a steroid sulfate-specific hydroxylase system in female rat liver microsomes. (3/122)

The sulfate-specific hydroxylase system in liver microsomes from rats has been investigated with respect to its substrate specificity. Eighteen different C18, C19, C21, and C27 steroid sulfates and the coresponding free steroids have been incubated with microsomal preparations from male and female rats. The sulfate-specific system was only present in preparations from female rats and primarily catalyzed hydroxylation in position 15beta but also in position 7beta. In contrast to this, male liver microsomes were more efficient than female liver microsomes in hydroxylating free steroids; these were hydroxylated in positions 2alpha,2beta,6alpha,6beta,7alpha,7beta,16alpha, and 18. The sulfate-specific hydroxylase system in female liver microsomes was found to have rigid requirements c concerning the structure of ring D in the substrate molecule; only 17beta-sulfates (C18 and C19 steroids) and 21-sulfates (C21 steroids) were hydroxylated. Less rigid criteria, however, exist concerning the structure of ring A. The following K-m values were determined for microsomal 15beta-hydroxylation: 5alpha-androstane-3alpha,17beta-diol disulfate, 17.2 muM; 5beta-androstane-3alpha,17beta-diol disulfate, 16muM;5alpha-androstane-3alpha,17beta-diol 17-sulfate, 26 muM; and estradiol 17-sulfate, 181 muM. Some of the regulatory mechanism controlling the activity of the sex-specific 15beta-hydroxylase system also have been studied and compared to the mechanism controlling the activities of the less specific 2alpha-, 7alpha-, and 18-hydroxylase systems active on 5alpha-[4-14C]androstane-3alpha,17beta-diol. Biliary drainage did not affect the 15beta-hydroxylase activity, whereas the 2alpha- and 7alpha-hydroxylase activities decreased..  (+info)

Antiarrhythmic, haemodynamic and metabolic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one hydrochloride in greyhounds following acute coronary artery ligation. (4/122)

1 The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. 2 ORG6001 administered either intravenously (2-10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. 3 In dogs pretreated with ORG6001, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. 4 Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. 5 These results suggest that ORG6001 may possess distinct advantages over presently-used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction.  (+info)

Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. (5/122)

Methoxychlor, a structural analog of the DDT pesticide, was previously shown to induce rat hepatic CYP2B and -3A mRNAs and the corresponding proteins [J Biochem Mol Toxicol 1998;12:315-323], Additionally, methoxychlor was found to activate the constitutive androstane receptor (CAR) system and induce CYP2B6 (J Biol Chem 1999;274:6043-6046), suggesting a mechanism for methoxychlor-mediated cytochrome P450 (P450) 2B induction. However, it has not been established whether CAR activation and P450 induction was due to methoxychlor per se and/or due to its metabolites. Also, a possible link between the estrogenic potency of methoxychlor metabolites and CAR activation or P450 induction was not investigated. The current study explores the ability of methoxychlor and its metabolites to activate CAR and whether their potency of CAR activation correlates with their respective estrogenicity. Methoxychlor and its metabolites [mono-OH-M [1,1,1-trichloro-2 (4-hydroxyphenyl)-2'-(4-methoxyphenyl)ethane]; bis-OH-M [1,1,1-trichloro-2,2'-bis(4-hydroxyphenyl)ethane]; ring-OH-M [1,1,1-trichloro-2(4-methoxyphenyl)-2'-(3-hydroxy-4-methoxyphenyl)ethane]; and tris-OH-M [1,1,1-trichloro-2(4-hydroxyphenyl)-2'-(3,4-dihydroxyphenyl)ethane]] were found to be potent activators of CAR. Dose response curves indicated that tris-OH-M is a more potent CAR activator than methoxychlor, mono-OH-M, and bis-OH-M. Since tris-OH-M is a much weaker estrogen receptor-alpha agonist than mono-OH-M and bis-OH-M, it seems that estrogenicity is not a significant factor in CAR activation. These findings indicate that alteration of methoxychlor-benzene rings, i.e., generation of phenolic constituents, does not appreciably alter CAR activation and suggest that a common structural motif in the methoxychlor class of compounds controls CAR activation. Studies are needed to identify the structural motif necessary for CAR activation and CYP2B induction.  (+info)

Local anaesthetic and antiarrhythmic properties of an aminosteroid: 3alpha-dimethyl-amino-5alpha-androstan-2beta-ol-17-one (Org. NA 13). (6/122)

1. The aminosteroid Org. NA13 (3alpha-dimethylamino-5alpha-androstan-2beta-ol-17-one) was shown to be a more potent local anaesthetic than lignocaine in rats and guinea-pigs. 2. Experimental arrhythmias induced in mice by chloroform, in rats by aconitine and in dogs by coronary artery ligation were corrected by Org. NA13 at doses from 10 to 50 mg/kg intravenously. 3. In contrast to lignocaine, other local anaesthetics and beta-adrenoceptor blocking drugs, Org. NA 13 did not show any activity against the arrhythmias induced by ouabian in dogs. 4. The acute toxicity in whole animals and myocardial toxicity in the rabbit isolated atrium appeared to be less than that observed with lignocaine.  (+info)

Steroid induction of delta-aminolevulinic acid synthase and porphyrins in liver. Structure-activity studies and the permissive effects of hormones on the induction process. (7/122)

Quantitative aspects and structure-activity relationships of the inducing effects of natural steroids on delta-aminolevulinic acid (ALA) synthase and porphyrins have been investigated in monolayer cultures of chick embryo liver cells maintained in a serum-free medium as well as in the chick embryo liver in ovo. Many 5 alpha and 5 beta metabolites of neutral C-19 and C-21 hormones and hormone precursors stimulated porphyrin formation and ALA-synthase induction in the cultured liver cells as we have previously described. In these inducing actions a number of 5 beta epimers (A:B cis) were found to be more potent than their corresponding 5 alpha epimers (A:B trans). The structure-activity relationship between 5 beta and 5 alpha steroid epimers with respect to ALA-synthase induction in culture was also found to prevail with respect to induction of this enzyme in chick embryo liver in ovo. Hemin in concentrations of 2 x 10(-7) M inhibited steroid induction of porphyrin formation, and CaMgEDTA enhanced the responsiveness of the cultured liver cells to steroids by approximately 10 times. The addition of insulin, or insulin plus hydrocortisone or insulin plus hydrocortisone plus triiodothyronine, was important for the maintenance of protein synthesis and essential for maximal expression of the ability of steroids to induce porphyrins and ALA-synthase in the "permissive" effect which insulin, hydrocortisone, and triiodothyronine exert on allylisopropylacetamide induction of porphyrins and ALA-synthase also extends to the induction process which is elicited by natural steroids. These findings also strongly suggest that the regulation of hepatic porphyrin-heme biosynthesis by endogenous as well as exogenous chemicals is significantly influenced by the internal hormonal milieu.  (+info)

Stereochemical aspects of the interaction between steroidal diamines and DNA. (8/122)

A complete series of stereoisomeric quaternised diaminoandrostanes, differing in their stereochemistry at the 3,5 and 17 positions, has been examined for effects on the thermal denaturation of calf thymus DNA and for the ability to remove and reverse the supercoiling of closed circular duplex PM2 DNA. In both types of test the eight isomers rank in the same order of effectiveness. The preferred stereochemistry for the quaternary substituents at positions 3 and 17 is beta; of these the orientation of the 17- substituent is more critical. Folding of the steroid skeleton between the A and B rings, as in 5beta-androstanes, diminishes effectiveness but does not necessarily abolish the effect on supercoiling. The over-riding importance of the C-D ring end of the steroid nucleus bearing a 17beta-amino substituent is confirmed by a comparison of the effects of five mon-amino androstanes. Relative helix=unwinding angles per bound steroidal diamine molecule have been determined for four of the isomers; for three 17beta compounds the estimated values are similar to that previously reported for irehdiamine A. For a fourth isomer the angle is 0.22 times that of ethidium, the lowest yet determined for any DNA-binding drug. The results lend further support to the argument that intercalation can be reled out, and alternative models for the binding mechanism are discussed.  (+info)

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1943. gadā žurnāls Science rakstīja par veiksmīgu olšūnas apaugļošanu mēģenē. 1977. gadā Oksfordas universitātes zooloģijas profesors Dž. Gerdons klonēja vairāk nekā 50 vardes. 1978. gadā veikta pirmā mēģenes (apaugļota ārpus mātes ķermeņa) bērna dzimšana - Luīze Brauna Apvienotajā Karalistē. 1987. gadā Džordža Vašingtona universitātes speciālisti sadalīja cilvēka iedīgli un klonēja to līdz 32 šūnām. 1996. gadā Skotijā tika klonēts pirmais dzīvnieks - aita Dollija. Kopš šī laika pasaulē klonēti dažādi dzīvnieki: teļi, kazas, peles, suņi u.c. Dzīvnieku klonēšana ir perspektīva metode dzīvnieku selekcijā un biotehnoloģiskajā pavairošanā, transplantēšanai nepieciešamo orgānu audzēšanā, iedzimto slimību pētīšanā. 1998.gadā Teksasā tika klonēti teļi. Tie ir ģenētiski uzlaboti mājlopi, lai varētu ražot pienu medicīniskiem nolūkiem. Zinātnieki Jaunzēlandē paziņoja, ka veiksmīgi klonējuši kādu ...
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TY - JOUR. T1 - C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells. AU - Moreira, V.M.. AU - Salvador, J. A. R.. AU - Matos Beja, A.. AU - Paixão, José A.. AU - Vasaitis, T. S.. AU - Njar, V. C. O.. PY - 2011/9/24. Y1 - 2011/9/24. N2 - Heterocycles are important features of biologically active molecules. Pyrrole, pyrimidine, indole, quinoline and purine are a few classes of heterocycles which have served as platforms for developing pharmaceutical agents for various applications (1). Many important naturally occurring steroids contain one or more heterocyclic ring(s), fused or attached to ring D, formed by modifications of the side chain (2). Moreover, attachment of heterocyclic moieties at diverse positions of the steroid core has provided novel compounds with a diverse range of biological activities including inhibition of cytochrome 17α-hydroxylase-C 17,20 -lyase (CYP17), one of the enzymes involved in androgen biosynthesis in ...
16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one: a synthetic adrenal hormone that reduced the incidence of tuberculosis and other opportunistic infections in AIDS patients
Matsuzawa, A and Yamamoto, T, "Lack of growth of a pregnancy-dependent mouse mammary tumor (tpdmt-4) in the absence of pituitary hormones." (1977). Subject Strain Bibliography 1977. 2328 ...
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Two years after arriving in America, Turkish center Enes Kanter speaks English fluently. But it wasnt always that way.. When I first got here, I couldnt speak any, he says now. My dad just taught me to say, Hello, and My name is Enes Kanter, and thats it.. In many ways, hes still making his introduction.. Unlike the other guy the Timberwolves most likely will choose if they keep the second overall pick, Kanter, in these weeks leading to Thursdays NBA draft, has done almost everything asked of him by NBA teams to whom the rugged 6-11 center still is something of a mystery.. Arizonas Derrick Williams worked out only for the Wolves and Cleveland -- owners of the drafts first two picks -- and went to Chicago for last months combine for only interviews and physical testing because, after a sensational sophomore season, he said, What do you want me to prove? I did that during the season.. Kanter, meanwhile, did every drill requested in Chicago and has auditioned for at least five ...
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As you grow older, the level of testosterone- the hormone that makes you a man, often drops and you suddenly find you are no longer to perform your best. Worry
5α-Androst-1-ene-3,17-dione (1-AD) is listed on the World Anti-Doping Agencys prohibited list as an "exogenous anabolic androgenic steroid". It could be marketed in dietary supplements. An excretion study was conducted with six male volunteers, to whom were orally administered 50 mg of 1-AD in one-time application. Urine samples were collected for two weeks. The metabolites were measured as TMS-derivatives with GC/MS. The intake was detectable up to eight days based on the main metabolite 3α-hydroxy-5α-androst-1-en-17-one (1-DHA). 1-DHA was synthesized from 5α-androst-2-en-17-one via the 2,3-epoxid as an intermediate and structurally identified with GC/MS and NMR. Other identified metabolites were 17β-hydroxy-5α-androst-1-en-3-one (1-testosterone), 5α-androst-1-ene-3α,17β-diol and 5α-androst-1-ene-3β,17β-diol. Furthermore two additional metabolites, presumably 18-hydroxy-5α-androst-1-ene-3,17-dione and 19-hydroxy-5α-androst-1-ene-3,17-dione, but until now without final ...
A process for the preparation of random propylene copolymers contairing copolymerized Cz-C1o-alk-l-enes by polymerization of propylene and Cz-C1o-alk-l- enes in the presence of a Ziegler-Natta catalyst system comprising a titanium- containing solid component a) comprising a compound of magnesium, a halogen, silica gel as support and a carboxylic ester as electron donor compound, and also, as cocatalysts, an aluminum compound b) and a further electron donor compound c), where propylene and the Cz-C1o-alk-l-enes are polymerized with one another at from 50 to 100°C at pressures in the range from 15 to 40 bar and mean residence times of from 0.5 to 5 hours and the support used in the titanium-containing solid component is a silica gel which has a mean particle diameter of from 5 to 200 J.tm, a mean particle diameter of the primary particles of from 1 to 10 J.tm and voids or channels having a mean diameter of from 1 to 10 J.tffi, which voids or channels have a macroscopic proportion by volume based ...
Accepted name: 3-ketosteroid 9α-monooxygenase. Reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9α-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O. Other name(s): KshAB; 3-ketosteroid 9α-hydroxylase. Systematic name: androsta-1,4-diene-3,17-dione,NADH:oxygen oxidoreductase (9α-hydroxylating). Comments: The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It is a two-component system consisting of a terminal oxygenase (KshA) and a ferredoxin reductase (KshB). The oxygenase contains a Rieske-type iron-sulfur center and non-heme iron. The reductase component is a flavoprotein containing an NAD-binding domain and a plant-type iron-sulfur cluster. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: References:. 1. Petrusma, M., Dijkhuizen, L. and ...
250 µCi quantities of Androst-4-ene-3, [1,2,6,7-3H(N)]-, 17-Dione are available for your research. Application of [3H] Androstenedione can be found in: effects of HCG and PMS on bioconversion in steroid biochemistry, breast cancer cell research, inhibition study of human placental aromatase in steroid biochemistry, in vitro metabolism studies in steroid chemistry; etc. ...
4 Major Functions The four major functions of the skeleton are: 1. Shape and support 2. Movement 3. Protection 4. Blood Production Try to remember: Should Mothers Protect Babies
Iron is essential for our blood production, oxygen capacity, quality and health. Better than prescribed unnatural iron supplements, our 100% organic herbal iron combo is packed ful
Turgay Celik, Esra Goktas, Hasan Kutsi Kabul, Sevket Balta, Atila Iyisoy, Selim Kilic, Mehmet Erdem, Muhammet Olgun, Huseiyn Aldemir, Salih Dasdelen, Okan Dalak, Fatih Kecilioglu, Fatma Nurefsan Selek, Ali Uygun, Bayram Kurt, Atilla Yilmaz, Orhan Mert, Sayed Mujtaba Haidari, Hamza Berlik, Ozlem Topcu, Israfil Akbay, Enes Gumler, Ismail Karakose, Aydin Mentese, Recep Tayip ...
Cancer is caused by an accumulation of genetic alterations that confer a survival advantage to the neoplastic cell. J. L. Jameson(p73) Oncogenes are "[g]enes that normally play a role in growth but, when overexpressed or mutated, can foster the growth of cancer." Oncogenes were discovered and characterized in viruses and animal experimental systems. These genes exist widely outside the systems in which they were discovered, and their normal cellular homologues are important in cell division and differentiation. Human oncogenes should be expressed according to style for human gene symbols (see , Human Gene Nomenclature). Mouse oncogenes (and other nonhuman oncogenes) should Less ...
Cancer is caused by an accumulation of genetic alterations that confer a survival advantage to the neoplastic cell. J. L. Jameson(p73) Oncogenes are "[g]enes that normally play a role in growth but, when overexpressed or mutated, can foster the growth of cancer." Oncogenes were discovered and characterized in viruses and animal experimental systems. These genes exist widely outside the systems in which they were discovered, and their normal cellular homologues are important in cell division and differentiation. Human oncogenes should be expressed according to style for human gene symbols (see , Human Gene Nomenclature). Mouse oncogenes (and other nonhuman oncogenes) should Less ...
by Beser, Omer F and Cokugras, Fugen Cullu and Erkan, Tulay and Kutlu, Tufan and Yagci, Rasit V and Ertem, Deniz and Yaşöz, Güniz and Yüksekkaya, Hasan Ali and Artan, Reha and Önal, Zerrin and Coşkun, Mehmet Enes and Aydoğan, Ayşen and Zorlu, Pelin and Akçaboy, Meltem and Tosun, Mahya Sultan and Urgancı, Nafiye and Kaya, Reyhan Gümüştekin and Satar, Mehmet and Yüce, Aysel and Karhan, Asuman Nur and Civan, Hasret Ayyıldız and Kasırga, Erhun and Volkan, Burcu and Certel, Alev Cansu and Güzelçiçek, Ahmet and Özkan, Tanju and Demirören, Kaan and Akşit, Sadık and Gökçe, Şule and Kızılcan, Sirmen and Dalgıç, Buket and Demirtaş, Zeliha and Karbuz, Adem and Kalaycı, Ayhan Gazi and Gülbahçe, Aliye and Sayar, Talip and Güler, Serhat and Aktar, Fesih and Kansu, Aydan and Altuntaş, Cansu and Ağalıoğlu, Dilfuza and Arslan, Duran and Arslan, Nur and Karakurt, Hasan and Sazak, Soner and Halıcıoğlu, Oya Baltalı and İnce, Gülberat and Üstündağ, Gonca and Soysal, ...
Editorial Staff, "testosterone," in Medicalopedia, February 10, 2020, [Permalink: https://www.medicalopedia.org/8347/myths-about-testosterone/testosterone-2/ ...
The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene. CAR is a member of the nuclear receptor superfamily and along with pregnane X receptor (PXR) functions as a sensor of endobiotic and xenobiotic substances. In response, expression of proteins responsible for the metabolism and excretion of these substances is upregulated. Hence, CAR and PXR play a major role in the detoxification of foreign substances such as drugs. Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as antagonists, were the basis for the naming of this receptor. More recently, dehydroepiandrosterone (DHEA), also an androstane, has been found to be an endogenous agonist of the CAR. CAR is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. Unlike most nuclear receptors, this transcriptional ...
Unsatisfied and unconvinced by what he was being taught about evolution at Marmara University in Istanbul, Turkey, 21-year old student Enes Kayan knew there was another side which was never presented in his courses. So in 2012, Enes, a member of the Marmara Young Vision Student Club, decided to organize a symposium in which he and other Marmara students could hear alternative views on evolution, including intelligent design. The idea that evidence against Darwinism, and even for intelligent design, could be freely presented at a university angered some students and professors, and about 300 of them staged a protest, which Enes said actually worked to his advantage as it brought publicity to the event, which was held on May 16-17, 2012 ...
Extractable filler for inserting medicine into animal tissue | Extractable filler for inserting medicine into animal tissue | 4-aminomethyl-1-aryl-cyclohexylamine compounds | Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives | Inhibitors of 11-.beta.-hydroxy steroid dehydrogenase type 1 |
When an autologous blood product is collected but not transfused, OPPS providers should bill Procedure 86890 (autologous blood or component, collection, processing, and storage; predeposited) or 86891(autologous blood or component, collection, processing, and storage; intra- or postoperative salvage) and the number of units collected but not transfused. Procedure 86890 and 86891 are intended to provide payment for the additional resources needed to provide these services, which are not captured when a blood product HCPCS code is not billed. Because billing 86890 or 86891 is only indicated when autologous blood is collected but not transfused, the OPPS provider should bill 86890 or 86891 on the date when the OPPS provider is certain the blood will not be transfused (i.e., date of a procedure or date of outpatient discharge), rather than on the date of the products collection or receipt from the supplier ...
In what part of the body is a sharks blood made? This was the subject of an enquiry that was recently sent to the Australian Museum.
There are no specific protocols for Recombinant Human Constitutive androstane receptor protein (ab81846). Please download our general protocols booklet
Creative-Proteomics offer cas 516-55-2 5-ALPHA-PREGNAN-3-BETA-OL-20-ONE (17A,21,21,21-D4, 97%+) 96% PURE. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
3β-Androstanediol, also known as 5α-androstane-3β,17β-diol, and often shortened to 3β-diol, is an endogenous steroid hormone. It is a 5α-reduced and 17β-hydroxylated metabolite of dehydroepiandrosterone (DHEA) as well as a 3β-hydroxylated metabolite of dihydrotestosterone (DHT). 3β-Diol is a selective, potent, high-affinity full agonist of the ERβ, and hence, an estrogen.[2] It has higher affinity for this receptor than estradiol.[2][contradictory] In contrast to ERβ, 3β-diol does not bind to the androgen receptor (AR).[3] 3β-Diol has been reported to also bind to ERα with low nanomolar affinity, with several-fold lower affinity relative to ERβ.[4][5] It has approximately 3% and 7% of the affinity of estradiol at the ERα and ERβ, respectively.[6][contradictory] Unlike its 3α-isomer, 3α-androstanediol (3α-diol), 3β-diol does not bind to the GABAA receptor.[7] ...
Health,Another importance of stem cells comes to the fore front as claimed by...The feat is to grow a human prostate gland in mice using embryonic...This would be helpful in treatment for prostate cancer and other dis... Monash University at Melbourne researchers had combined human emb... Weve taken these embryonic stem cells to a point where they are...,Mice,model,becomes,surrogate,for,human,prostate,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Read "A green organocatalyzed one-pot protocol for efficient synthesis of new substituted pyrimido[4,5-d]pyrimidinones using a Biginelli-like reaction, Research on Chemical Intermediates" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
... is an emerging biopharmaceutical company focused on commercializing a novel class of patented compounds known as ceragenins or CSAs. These compounds have broad-spectrum activity mimicking those of endogenous antimicrobial peptides such as LL-37. CSAs, however, are not peptides; rather synthetic small molecules that can be manufactured at large scale and are not subject […]. Read More. ...
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An open letter in support of transformative biotechnology and social innovation: SANKO University Innovation Summit in Medicine and Integrative Biology, Gaziantep, Turkey, May 5-7, 2016, Eyüp Saygılı, Alaa Abou-Zeid, Salih Akkın, Eleni Aklillu, İbrahim Barlas, Alexander Borda-Rodriguez, Filiz Boschele, Zafer Çetin, Enes Coşkun, Yavuz Coşkun, Güner Dağlı, Türkan Dai, Collet Dandara, Türkay Dereli, Levent Elbeyli, Laszlo Endrenyi, Can Eyigün, Alexandros Georgakilas, Bircan Günbulut, Kıvanç Güngör, Asım Güzelbey, Can Hekim, Farah Huzair, Sabit Kimyon, Ümit Karakaş, Biaoyang Lin, Adrián LLerena, Collen Masimirembwa, Ruth McNally, Alper Mete, Peşvin Sancar, Sanjeeva Srivastava, Lotte Steuten, Oylum Tanrıöver, David Tyfield, Volkan Töre, Deniz Vuruşkan, Wei Wang, Louise Warnich, Ambroise Wonkam, Yusuf Yıldırım, İsmet Yılmaz, Ahmet Sınav, and Nezih Hekim. ...
28-norlup-20(29)-en-3beta-hydroxy-17beta-hydroperoxide: antiproliferative triterpene from leaves of Melaleuca ericifolia; structure in first source
chemBlink provides information about CAS # 1338221-87-6, (3alpha,17beta)-4-Chloro-17-methylandrosta-1,4-diene-3,17-diol, molecular formula: C20H29ClO2.
The problem of global contamination from uranium (U) is a difficult task. The present investigation was aimed to study the possibilities of using prostate tissue as a biological material for global environmental monitoring of U. The U content in non-hypertrophic prostate of apparently healthy 64 residents of uncontaminated territory was measured by instrumental neutron activation analysis and inductively coupled plasma mass spectrometry. Mean values (M  SΕΜ) for the mass fraction of U in prostate of all subjects taken together was 0.0049 ± 0.0014 mg/kg of dry tissue. In order to estimate the effect of age on the investigated parameter we used three age groups: 13-20 years, 21-40 years, and 41-60 year. Mean values (M  SΕΜ) for the mass fraction of U (mg/kg of dry tissue) in age groups were as follows: 0.0023 ± 0.0007, 0.0021 ± 0.0005, and 0.0077 ± 0.0026, respectively. For the first time statistically significant (p ï‚£ 0.05, t- test) and exponential increase of the U content in
Excessive iron intake can also cause problems, as it is stored in the body. Too much iron in the tissues and organs leads to the production of free radicals and increases the need for vitamin E. There is a differentiation between plant and animal sources of iron. In animal sources, iron is often attached to proteins called haeme proteins, and referred to as haeme iron. In plant sources, iron is not attached to haeme proteins, and is classified as non-haeme iron. Haeme iron is typically absorbed at a rate of 7-35%, and non-haeme iron at a rate of 2-20%. Good food sources of iron include: - haeme iron: liver, red meat, shellfish, egg yolks - non-heame iron: legumes (lentils, beans, chickpeas), dark leafy greens (spinach, swiss chard), dried fruit (prunes, apricots) Vitamin C can increase the absorption of iron by as much as 30%, so aim to include foods rich in this essential nutrient if you are iron deficient. Sources: Prescription for nutritional healing. 4th edition. Phyllis A. Balch, CNC & ...
Testosterone modulates seizure susceptibility, but the underlying mechanisms are obscure. Recently, we demonstrated that testosterone affects seizure activity via its conversion to neurosteroids in the brain. Androstanediol (5α-androstan-3α,17β-diol) is an endogenous neurosteroid synthesized from testosterone. However, the molecular mechanism underlying the seizure protection activity of androstanediol remains unclear. Here we show that androstanediol has positive allosteric activity as a GABAA receptor modulator. In whole-cell recordings from acutely dissociated hippocampus CA1 pyramidal cells, androstanediol (but not its 3β-epimer) produced a concentration-dependent enhancement of GABA-activated currents (EC50, 5-μM). At 1μM, androstanediol produced a 50% potentiation of GABA responses. In the absence of GABA, androstanediol has moderate direct effects on GABAA receptor-mediated currents at high concentrations (10-μM). Systemic doses of androstanediol (5-100 mg/kg), but not its ...
3α-androstanediol glucuronide is a product of androgens degradation, particularly by intracellular reduction of DHT. Its determination is used in management of diseases with excessive androgen production. It reflects skin androgen activity, which is dependent on the presence of 5α-reductase enzyme, converting testosterone to DHT. Accordingly, the measurement of 3α-androstanediol glucuronide is an indirect way of testing DHT and 5α-reductase activity.. ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion ...
Estrane and pregnane List of androstanes Wilson JD (1996). "Role of dihydrotestosterone in androgen action". Prostate Suppl. 6 ...
They include the androstanes androstadienol, androstadienone, androstenol, and androstenone and the estrane estratetraenol. ... the androstanes dehydroepiandrosterone (DHEA; prasterone), and dehydroepiandrosterone sulfate (DHEA-S; prasterone sulfate), and ...
... and other 1-dehydrogenated androstanes. The drug has been sold on the Internet as a designer steroid and "dietary supplement". ...
List of androgens/anabolic steroids List of neurosteroids § Androstanes List of neurosteroids § Pheromones and pherines Motofei ...
Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as ...
In contrast to the androstanes, 50 or 100 mg oral pregnenolone has been found to significantly and in fact "strongly" increase ...
... and the androstanes (e.g., danazol, ethisterone) and estranes (e.g., norethisterone, levonorgestrel), which are testosterone ...
This is a list of androstanes, or androstane derivatives. Androstanol 3α,5α-Androstanol (5α-androstan-3α-ol) - an endogenous ...
... , also known as 17-(3-pyridyl)-5α-androst-16-en-3-one, is an active metabolite of abiraterone acetate that has been found to possess androgenic activity and to stimulate prostate cancer progression.[1][2] It is formed as follows: abiraterone acetate to abiraterone by esterases; abiraterone to Δ4-abiraterone by 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase; and Δ4-abiraterone to 3-keto-5α-abiraterone by 5α-reductase.[1][2] 3-Keto-5α-abiraterone may counteract the clinical effectiveness of abiraterone acetate, and so inhibition of its formation using the 5α-reductase inhibitor dutasteride is being investigated as an adjunct to abiraterone acetate in the treatment of prostate cancer.[1][2] ...
Androstanes. *Hepatotoxins. *Ketones. *Organochlorides. *Science and technology in East Germany. *World Anti-Doping Agency ...
Androstanes. *Aromatase inhibitors. *Exercise physiology. *Drugs in sport. *World Anti-Doping Agency prohibited substances ...
Androstanes. *Hepatotoxins. *World Anti-Doping Agency prohibited substances. *Steroid stubs. *Genito-urinary system drug stubs ...
Androstanes. *Estrogens. *GABAA receptor positive allosteric modulators. *Ketones. *Testosterone. *World Anti-Doping Agency ...
Androstanes. *Antiestrogens. *Antigonadotropins. *Cholesterol side-chain cleavage enzyme inhibitors. *CYP17A1 inhibitors. * ...
... (brand names Androxan, Neo-Ponden, Neo-Pondus), also known as 17α-methyl-5α-androstano[3,2-c]isoxazol-17β-ol, is an orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of dihydrotestosterone (DHT) that is marketed in Spain and Italy.[1][2][3][4] It is closely related to stanozolol, differing only in having an isoxazole instead of pyrazole ring fused to the A ring,[4] and is also related to furazabol, prostanozol, and danazol. ...
... , or methenolone enanthate, sold under the brand names Primobolan Depot and Nibal Injection, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure.[2][3][4][5][6][7] It is given by injection into muscle.[6] Although it was widely used in the past, the drug has mostly been discontinued and hence is now mostly no longer available.[5][6][3] A related drug, metenolone acetate, is taken by mouth.[6] Side effects of metenolone enanthate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.[6] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[6][8] It has moderate anabolic effects and weak androgenic effects, as well as no estrogenic effects or risk of liver damage.[6][8] Metenolone enanthate is a metenolone ...
Androstanes. *Testosterone esters. *Genito-urinary system drug stubs. *Steroid stubs. Hidden categories: *Chemical pages ...
The principal clinical indication of drostanolone propionate in the United States as well as international markets was the treatment of advanced inoperable breast cancer in women.[1]. Hormonal treatment is part of the complex therapy for some kind of tumors, particularly the ones associated with hormone-active tissues like breast or prostate cancer. Some types of breast cancer cells, expressing estrogen receptors (called ER+ cancers), use estrogen for their growth and dissemination. That is why drugs that block estrogen receptors or decrease their expression on the cell membrane, antiestrogens, could limit the tumor spread and size. Drostanolone propionate has been FDA approved[7] as an antiestrogenic drug for the treatment of breast cancer. By the time of its release, there were not many alternatives for patients suffering from breast cancer and drostanolone propionate was a revolution for these patients. As it has lower androgenic rate compared to testosterone, the risk of virilization is much ...
This is a list of androstanes, or androstane derivatives. Androstanol 3α,5α-Androstanol (5α-androstan-3α-ol) - an endogenous ...
pronamide results in increased androgen metabolic process] which results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Androstanes. *Androstenes. *Androstenols. *BCRP/ABCG2 Substrates. *Cytochrome P-450 CYP2B6 Substrates. *Cytochrome P-450 ...
C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells. / Moreira ... C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells. European ... title = "C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells", ... T1 - C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells ...
16-substituted androstanes and 16-substituted androstenes. US5006517 *. Jul 24, 1989. Apr 9, 1991. Progenics, Inc.. Treatment ... Derivatives of DHEA, such as 16-substituted androstanes and 16-substituted androstenes, are described in U.S. Pat. No. ... is selected from the group consisting of 16-substituted androstanes, 16-substituted androstenes, 17 hydroxy-steroids, α-HET, β- ...
Androstanes as androgen receptor modulators. November, 2004. Wang. 20080161314. Novel Diazabicyclic Aryl Derivatives and Their ...
Androstanes, 19-Norandrostanes and their Unsaturated Analogs. Journal of the American Chemical Society, 83: 1478-1491. ...
Androstanes testosterone 19 Estranes estradiol 18 See also. *Batrachotoxin *List of steroid abbreviations ...
CoMFA models for androstanes. A 5?-Androstan-3?-ol (pIC50?=?6.1) shown with the steric component of the CoMFA model. Green ... Among the androstanes, 6 out of 11 compounds were predicted correctly as activators and 9 out of 14 compounds were classified ... CoMSIA models for androstanes. A - 17?-dihydroandrosterone (pIC50?=?5.38) with the steric component of the CoMSIA model. Blue ... A. 4D-QSAR for androstanes showing the active conformation of 5?-Androstan-3?-ol, B 4D-QSAR for pregnanes showing the active ...
Unsaturated androstanes which are substituted with one or more hydroxyl groups in any position in the ring system. ...
Androstanes [D04.808.054]. *Androstanols [D04.808.054.040]. *Dihydrotestosterone [D04.808.054.040.248]. *Hormones, Hormone ...
Categories: Androstanes Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 1 ...
Androstanes: 8*Androstanols*4,5-epoxy-17-hydroxy-2-methylsulfonyl-3-androstanone ...
Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion ...
19-alkyl androstanes GB1182669A (en) * 1966-07-28. 1970-03-04. Foss Mfg Company Inc. Shoe stiffeners ...
Bohumil, P., Unsaturated androstanes. Czech. 127,564, 1968;. Bohumil P. Chem Abstr 1969;70:68637.. Anyone have any idea what ... Bohumil, P., Unsaturated androstanes. Czech. 127,564, 1968;. Bohumil P. Chem Abstr 1969;70:68637.. Anyone have any idea what ...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
11:30 Hydroxy and Ketonic Androstanes: A New Class of Sterol Diagenetic Products in Peat. Luke A. Avsejs, Chris J. Nott, James ...
ANDROSTANES AND PREGNANES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR. Methods, compositions, and compounds for modulating the ...
19-Oxygenated-5α-androstanes for the enhancement of libido US4966897A (en) 1990-10-30. 4-substituted 17β-(cyclopropyloxy) ...
Norden S., Bender M., Rullkötter J., Christoffers J., 2011. Androstanes with modified carbon skeletons. Eur. J. Org. Chem. 4543 ...
Later, androstanes were found to repress constitutive activity of CAR in cell-based assays, which became the basis of "CAR" to ... Although androstanes are useful to identify CAR activators in cell-based reactivation assays (Sueyoshi et al., 1999), there is ... no biologic significance to CAR being repressed by androstanes. In addition, an androstane also activates the pregnane X ...
  • Androstanes generally buy online steroids with credit card and increase your how would like to build muscle and loss fat. (reed-electronics.com)
  • CAR has previously been shown to be an apparently constitutive transactivator, and this constitutive activity is inhibited by androstanes acting as inverse agonists. (asm.org)
  • It is the main precursor to pheromones, a lot of which are adrostenes, androstanes, and androstadienes. (friarsroast.com)
  • Previous studies demonstrated that P. lanosocoeruleum KCH 3012 metabolizes androstanes to the corresponding lactones with high yield. (biomedcentral.com)