The family of steroids from which the androgens are derived.

Transfer of the 1-pro-R and the 1-pro-S hydrogen atoms of ethanol in metabolic reductions in vivo. (1/122)

The transfer of deuterium from [1 R-2H]ethanol and [1 S-2H]-ethanol to reduced metabolites of administered compounds was measured in female rats provided with bile fistulas. Administered cyclohexanone was reduced to cyclohexanol, and in this reduction hydrogen was transferred only from the 1-pro-R position of the ethanol. The deuterium content in the cyclohexanol was about 67% of that in the ethanol. In the reduction of the 17-oxo group in 3beta-hydroxy-5alpha-androstan-17-one, hydrogen was transferred both from the 1-pro-R position and the 1-pro-S position, resulting in degrees of labelling that were about 25% and 2%, respectively, of those in the specific positions of the ethanols. The 1-pro-R and 1-pro-S positions of ethanol contributed about 9% and 5%, respectively, of the 3beta hydrogen in lithocholic acid formed from 3-oxo-5beta-cholanoic acid. The results indicate that alcohol dehydrogenase and aldehyde dehydrogenase do not share a common pool of NAD, and that NADH formed during acetaldehyde oxidation is utilized for reductions in the cytosol to a smaller extent than the NADH formed in the alcohol dehydrogenase reaction. This result supports the concept that aldehyde oxidation is mainly an intramitochondrial process. The relatively extensive utilization of the 1-pro-S hydrogen of ethanol in the reduction of 3-oxo-5beta-cholanoic acid, that is probably NADPH-dependent, indicates that cytosolic NADPH may be produced from malate or isocitrate formed intramitochondrially.  (+info)

Induction of delta-aminolevulinic acid synthetase in isolated rat liver cells by steroids. (2/122)

The role of steroids in regulation of delta-aminolevulinic acid synthetase has been studied in isolated rat liver cell suspensions under conditions previously shown to support inducation of the enzyme by drugs. Addition of a variety of C-19 and C-21 steroids to cell suspensions resulted, after 4 to 6 hours of incubation, in 2- to 5-fold increase in the activity of delta-aminolevulinic acid synthetase as measured in liver cell homogenates. The increase was prevented by cycloheximide. The most active steroid inducers tested were pregnene or pregnane derivatives with keto or hydroxyl groups at C-3 and C-20; in particular a beta-hydroxyl group at C-20 enhanced activity. These C-21 steroids at optimal initial concentrations caused 3- to 5-fold induction over 4 hours. A number of C-19 androstene and androstane compounds caused 2- to 3-fold inducation over the same period. Hydrocortisone had no effect. For a variety of androstane and pregnane derivatives, inducation by 5alphaH steroids was as great as or greater than that by 5betaH compounds, in contrast to previous findings in chick embryo liver. Induction of delta-aminolevulinic acid synthetase by steroids in isolated liver cells was shown to be subject to feedback repression by hemin.  (+info)

Regulation and substrate specificity of a steroid sulfate-specific hydroxylase system in female rat liver microsomes. (3/122)

The sulfate-specific hydroxylase system in liver microsomes from rats has been investigated with respect to its substrate specificity. Eighteen different C18, C19, C21, and C27 steroid sulfates and the coresponding free steroids have been incubated with microsomal preparations from male and female rats. The sulfate-specific system was only present in preparations from female rats and primarily catalyzed hydroxylation in position 15beta but also in position 7beta. In contrast to this, male liver microsomes were more efficient than female liver microsomes in hydroxylating free steroids; these were hydroxylated in positions 2alpha,2beta,6alpha,6beta,7alpha,7beta,16alpha, and 18. The sulfate-specific hydroxylase system in female liver microsomes was found to have rigid requirements c concerning the structure of ring D in the substrate molecule; only 17beta-sulfates (C18 and C19 steroids) and 21-sulfates (C21 steroids) were hydroxylated. Less rigid criteria, however, exist concerning the structure of ring A. The following K-m values were determined for microsomal 15beta-hydroxylation: 5alpha-androstane-3alpha,17beta-diol disulfate, 17.2 muM; 5beta-androstane-3alpha,17beta-diol disulfate, 16muM;5alpha-androstane-3alpha,17beta-diol 17-sulfate, 26 muM; and estradiol 17-sulfate, 181 muM. Some of the regulatory mechanism controlling the activity of the sex-specific 15beta-hydroxylase system also have been studied and compared to the mechanism controlling the activities of the less specific 2alpha-, 7alpha-, and 18-hydroxylase systems active on 5alpha-[4-14C]androstane-3alpha,17beta-diol. Biliary drainage did not affect the 15beta-hydroxylase activity, whereas the 2alpha- and 7alpha-hydroxylase activities decreased..  (+info)

Antiarrhythmic, haemodynamic and metabolic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one hydrochloride in greyhounds following acute coronary artery ligation. (4/122)

1 The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. 2 ORG6001 administered either intravenously (2-10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. 3 In dogs pretreated with ORG6001, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. 4 Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. 5 These results suggest that ORG6001 may possess distinct advantages over presently-used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction.  (+info)

Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. (5/122)

Methoxychlor, a structural analog of the DDT pesticide, was previously shown to induce rat hepatic CYP2B and -3A mRNAs and the corresponding proteins [J Biochem Mol Toxicol 1998;12:315-323], Additionally, methoxychlor was found to activate the constitutive androstane receptor (CAR) system and induce CYP2B6 (J Biol Chem 1999;274:6043-6046), suggesting a mechanism for methoxychlor-mediated cytochrome P450 (P450) 2B induction. However, it has not been established whether CAR activation and P450 induction was due to methoxychlor per se and/or due to its metabolites. Also, a possible link between the estrogenic potency of methoxychlor metabolites and CAR activation or P450 induction was not investigated. The current study explores the ability of methoxychlor and its metabolites to activate CAR and whether their potency of CAR activation correlates with their respective estrogenicity. Methoxychlor and its metabolites [mono-OH-M [1,1,1-trichloro-2 (4-hydroxyphenyl)-2'-(4-methoxyphenyl)ethane]; bis-OH-M [1,1,1-trichloro-2,2'-bis(4-hydroxyphenyl)ethane]; ring-OH-M [1,1,1-trichloro-2(4-methoxyphenyl)-2'-(3-hydroxy-4-methoxyphenyl)ethane]; and tris-OH-M [1,1,1-trichloro-2(4-hydroxyphenyl)-2'-(3,4-dihydroxyphenyl)ethane]] were found to be potent activators of CAR. Dose response curves indicated that tris-OH-M is a more potent CAR activator than methoxychlor, mono-OH-M, and bis-OH-M. Since tris-OH-M is a much weaker estrogen receptor-alpha agonist than mono-OH-M and bis-OH-M, it seems that estrogenicity is not a significant factor in CAR activation. These findings indicate that alteration of methoxychlor-benzene rings, i.e., generation of phenolic constituents, does not appreciably alter CAR activation and suggest that a common structural motif in the methoxychlor class of compounds controls CAR activation. Studies are needed to identify the structural motif necessary for CAR activation and CYP2B induction.  (+info)

Local anaesthetic and antiarrhythmic properties of an aminosteroid: 3alpha-dimethyl-amino-5alpha-androstan-2beta-ol-17-one (Org. NA 13). (6/122)

1. The aminosteroid Org. NA13 (3alpha-dimethylamino-5alpha-androstan-2beta-ol-17-one) was shown to be a more potent local anaesthetic than lignocaine in rats and guinea-pigs. 2. Experimental arrhythmias induced in mice by chloroform, in rats by aconitine and in dogs by coronary artery ligation were corrected by Org. NA13 at doses from 10 to 50 mg/kg intravenously. 3. In contrast to lignocaine, other local anaesthetics and beta-adrenoceptor blocking drugs, Org. NA 13 did not show any activity against the arrhythmias induced by ouabian in dogs. 4. The acute toxicity in whole animals and myocardial toxicity in the rabbit isolated atrium appeared to be less than that observed with lignocaine.  (+info)

Steroid induction of delta-aminolevulinic acid synthase and porphyrins in liver. Structure-activity studies and the permissive effects of hormones on the induction process. (7/122)

Quantitative aspects and structure-activity relationships of the inducing effects of natural steroids on delta-aminolevulinic acid (ALA) synthase and porphyrins have been investigated in monolayer cultures of chick embryo liver cells maintained in a serum-free medium as well as in the chick embryo liver in ovo. Many 5 alpha and 5 beta metabolites of neutral C-19 and C-21 hormones and hormone precursors stimulated porphyrin formation and ALA-synthase induction in the cultured liver cells as we have previously described. In these inducing actions a number of 5 beta epimers (A:B cis) were found to be more potent than their corresponding 5 alpha epimers (A:B trans). The structure-activity relationship between 5 beta and 5 alpha steroid epimers with respect to ALA-synthase induction in culture was also found to prevail with respect to induction of this enzyme in chick embryo liver in ovo. Hemin in concentrations of 2 x 10(-7) M inhibited steroid induction of porphyrin formation, and CaMgEDTA enhanced the responsiveness of the cultured liver cells to steroids by approximately 10 times. The addition of insulin, or insulin plus hydrocortisone or insulin plus hydrocortisone plus triiodothyronine, was important for the maintenance of protein synthesis and essential for maximal expression of the ability of steroids to induce porphyrins and ALA-synthase in the "permissive" effect which insulin, hydrocortisone, and triiodothyronine exert on allylisopropylacetamide induction of porphyrins and ALA-synthase also extends to the induction process which is elicited by natural steroids. These findings also strongly suggest that the regulation of hepatic porphyrin-heme biosynthesis by endogenous as well as exogenous chemicals is significantly influenced by the internal hormonal milieu.  (+info)

Stereochemical aspects of the interaction between steroidal diamines and DNA. (8/122)

A complete series of stereoisomeric quaternised diaminoandrostanes, differing in their stereochemistry at the 3,5 and 17 positions, has been examined for effects on the thermal denaturation of calf thymus DNA and for the ability to remove and reverse the supercoiling of closed circular duplex PM2 DNA. In both types of test the eight isomers rank in the same order of effectiveness. The preferred stereochemistry for the quaternary substituents at positions 3 and 17 is beta; of these the orientation of the 17- substituent is more critical. Folding of the steroid skeleton between the A and B rings, as in 5beta-androstanes, diminishes effectiveness but does not necessarily abolish the effect on supercoiling. The over-riding importance of the C-D ring end of the steroid nucleus bearing a 17beta-amino substituent is confirmed by a comparison of the effects of five mon-amino androstanes. Relative helix=unwinding angles per bound steroidal diamine molecule have been determined for four of the isomers; for three 17beta compounds the estimated values are similar to that previously reported for irehdiamine A. For a fourth isomer the angle is 0.22 times that of ethidium, the lowest yet determined for any DNA-binding drug. The results lend further support to the argument that intercalation can be reled out, and alternative models for the binding mechanism are discussed.  (+info)

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1, 3, 6, 8-Tetramethy1-2, 4, 5, 7 (1H, 3H, 6H, 8H) pyrimido [5, 4-,I,g,/I,] pteridinetetrone and 1, 3, 5, 7-Tetramethy1-2, 4, 6, 8 (1H, 3H, 5H, 7H)-pyrimido [4, 5-,I,g,/I,] pteridinetetrone (1971 ...
TY - JOUR. T1 - C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells. AU - Moreira, V.M.. AU - Salvador, J. A. R.. AU - Matos Beja, A.. AU - Paixão, José A.. AU - Vasaitis, T. S.. AU - Njar, V. C. O.. PY - 2011/9/24. Y1 - 2011/9/24. N2 - Heterocycles are important features of biologically active molecules. Pyrrole, pyrimidine, indole, quinoline and purine are a few classes of heterocycles which have served as platforms for developing pharmaceutical agents for various applications (1). Many important naturally occurring steroids contain one or more heterocyclic ring(s), fused or attached to ring D, formed by modifications of the side chain (2). Moreover, attachment of heterocyclic moieties at diverse positions of the steroid core has provided novel compounds with a diverse range of biological activities including inhibition of cytochrome 17α-hydroxylase-C 17,20 -lyase (CYP17), one of the enzymes involved in androgen biosynthesis in ...
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16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one: a synthetic adrenal hormone that reduced the incidence of tuberculosis and other opportunistic infections in AIDS patients
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局在化一重項ビラジカルの反応性に及ぼす窒素原子効果と置換基効果, 基礎有機化学討論会要旨集(基礎有機化学連合討論会予稿集), 2011巻, 0号, pp.350-pp.350, ...
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5α-Androst-1-ene-3,17-dione (1-AD) is listed on the World Anti-Doping Agencys prohibited list as an exogenous anabolic androgenic steroid. It could be marketed in dietary supplements. An excretion study was conducted with six male volunteers, to whom were orally administered 50 mg of 1-AD in one-time application. Urine samples were collected for two weeks. The metabolites were measured as TMS-derivatives with GC/MS. The intake was detectable up to eight days based on the main metabolite 3α-hydroxy-5α-androst-1-en-17-one (1-DHA). 1-DHA was synthesized from 5α-androst-2-en-17-one via the 2,3-epoxid as an intermediate and structurally identified with GC/MS and NMR. Other identified metabolites were 17β-hydroxy-5α-androst-1-en-3-one (1-testosterone), 5α-androst-1-ene-3α,17β-diol and 5α-androst-1-ene-3β,17β-diol. Furthermore two additional metabolites, presumably 18-hydroxy-5α-androst-1-ene-3,17-dione and 19-hydroxy-5α-androst-1-ene-3,17-dione, but until now without final ...
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Accepted name: 3-ketosteroid 9α-monooxygenase. Reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9α-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O. Other name(s): KshAB; 3-ketosteroid 9α-hydroxylase. Systematic name: androsta-1,4-diene-3,17-dione,NADH:oxygen oxidoreductase (9α-hydroxylating). Comments: The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It is a two-component system consisting of a terminal oxygenase (KshA) and a ferredoxin reductase (KshB). The oxygenase contains a Rieske-type iron-sulfur center and non-heme iron. The reductase component is a flavoprotein containing an NAD-binding domain and a plant-type iron-sulfur cluster. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: References:. 1. Petrusma, M., Dijkhuizen, L. and ...
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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
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Our laboratory studies how hematopoietic stem cells (HSC) regulate blood production during the lifetime of an ever-changing organism.
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Cancer is caused by an accumulation of genetic alterations that confer a survival advantage to the neoplastic cell. J. L. Jameson(p73) Oncogenes are [g]enes that normally play a role in growth but, when overexpressed or mutated, can foster the growth of cancer. Oncogenes were discovered and characterized in viruses and animal experimental systems. These genes exist widely outside the systems in which they were discovered, and their normal cellular homologues are important in cell division and differentiation. Human oncogenes should be expressed according to style for human gene symbols (see , Human Gene Nomenclature). Mouse oncogenes (and other nonhuman oncogenes) should Less ...
Cancer is caused by an accumulation of genetic alterations that confer a survival advantage to the neoplastic cell. J. L. Jameson(p73) Oncogenes are [g]enes that normally play a role in growth but, when overexpressed or mutated, can foster the growth of cancer. Oncogenes were discovered and characterized in viruses and animal experimental systems. These genes exist widely outside the systems in which they were discovered, and their normal cellular homologues are important in cell division and differentiation. Human oncogenes should be expressed according to style for human gene symbols (see , Human Gene Nomenclature). Mouse oncogenes (and other nonhuman oncogenes) should Less ...
by Beser, Omer F and Cokugras, Fugen Cullu and Erkan, Tulay and Kutlu, Tufan and Yagci, Rasit V and Ertem, Deniz and Yaşöz, Güniz and Yüksekkaya, Hasan Ali and Artan, Reha and Önal, Zerrin and Coşkun, Mehmet Enes and Aydoğan, Ayşen and Zorlu, Pelin and Akçaboy, Meltem and Tosun, Mahya Sultan and Urgancı, Nafiye and Kaya, Reyhan Gümüştekin and Satar, Mehmet and Yüce, Aysel and Karhan, Asuman Nur and Civan, Hasret Ayyıldız and Kasırga, Erhun and Volkan, Burcu and Certel, Alev Cansu and Güzelçiçek, Ahmet and Özkan, Tanju and Demirören, Kaan and Akşit, Sadık and Gökçe, Şule and Kızılcan, Sirmen and Dalgıç, Buket and Demirtaş, Zeliha and Karbuz, Adem and Kalaycı, Ayhan Gazi and Gülbahçe, Aliye and Sayar, Talip and Güler, Serhat and Aktar, Fesih and Kansu, Aydan and Altuntaş, Cansu and Ağalıoğlu, Dilfuza and Arslan, Duran and Arslan, Nur and Karakurt, Hasan and Sazak, Soner and Halıcıoğlu, Oya Baltalı and İnce, Gülberat and Üstündağ, Gonca and Soysal, ...
Editorial Staff, testosterone, in Medicalopedia, February 10, 2020, [Permalink: https://www.medicalopedia.org/8347/myths-about-testosterone/testosterone-2/ ...
The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene. CAR is a member of the nuclear receptor superfamily and along with pregnane X receptor (PXR) functions as a sensor of endobiotic and xenobiotic substances. In response, expression of proteins responsible for the metabolism and excretion of these substances is upregulated. Hence, CAR and PXR play a major role in the detoxification of foreign substances such as drugs. Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as antagonists, were the basis for the naming of this receptor. More recently, dehydroepiandrosterone (DHEA), also an androstane, has been found to be an endogenous agonist of the CAR. CAR is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. Unlike most nuclear receptors, this transcriptional ...
Unsatisfied and unconvinced by what he was being taught about evolution at Marmara University in Istanbul, Turkey, 21-year old student Enes Kayan knew there was another side which was never presented in his courses. So in 2012, Enes, a member of the Marmara Young Vision Student Club, decided to organize a symposium in which he and other Marmara students could hear alternative views on evolution, including intelligent design. The idea that evidence against Darwinism, and even for intelligent design, could be freely presented at a university angered some students and professors, and about 300 of them staged a protest, which Enes said actually worked to his advantage as it brought publicity to the event, which was held on May 16-17, 2012 ...
Extractable filler for inserting medicine into animal tissue | Extractable filler for inserting medicine into animal tissue | 4-aminomethyl-1-aryl-cyclohexylamine compounds | Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives | Inhibitors of 11-.beta.-hydroxy steroid dehydrogenase type 1 |
When an autologous blood product is collected but not transfused, OPPS providers should bill Procedure 86890 (autologous blood or component, collection, processing, and storage; predeposited) or 86891(autologous blood or component, collection, processing, and storage; intra- or postoperative salvage) and the number of units collected but not transfused. Procedure 86890 and 86891 are intended to provide payment for the additional resources needed to provide these services, which are not captured when a blood product HCPCS code is not billed. Because billing 86890 or 86891 is only indicated when autologous blood is collected but not transfused, the OPPS provider should bill 86890 or 86891 on the date when the OPPS provider is certain the blood will not be transfused (i.e., date of a procedure or date of outpatient discharge), rather than on the date of the products collection or receipt from the supplier ...
In what part of the body is a sharks blood made? This was the subject of an enquiry that was recently sent to the Australian Museum.
There are no specific protocols for Recombinant Human Constitutive androstane receptor protein (ab81846). Please download our general protocols booklet
Creative-Proteomics offer cas 516-55-2 5-ALPHA-PREGNAN-3-BETA-OL-20-ONE (17A,21,21,21-D4, 97%+) 96% PURE. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
3β-Androstanediol, also known as 5α-androstane-3β,17β-diol, and often shortened to 3β-diol, is an endogenous steroid hormone. It is a 5α-reduced and 17β-hydroxylated metabolite of dehydroepiandrosterone (DHEA) as well as a 3β-hydroxylated metabolite of dihydrotestosterone (DHT). 3β-Diol is a selective, potent, high-affinity full agonist of the ERβ, and hence, an estrogen.[2] It has higher affinity for this receptor than estradiol.[2][contradictory] In contrast to ERβ, 3β-diol does not bind to the androgen receptor (AR).[3] 3β-Diol has been reported to also bind to ERα with low nanomolar affinity, with several-fold lower affinity relative to ERβ.[4][5] It has approximately 3% and 7% of the affinity of estradiol at the ERα and ERβ, respectively.[6][contradictory] Unlike its 3α-isomer, 3α-androstanediol (3α-diol), 3β-diol does not bind to the GABAA receptor.[7] ...
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Read A green organocatalyzed one-pot protocol for efficient synthesis of new substituted pyrimido[4,5-d]pyrimidinones using a Biginelli-like reaction, Research on Chemical Intermediates on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
CSA BioTech is an emerging biopharmaceutical company focused on commercializing a novel class of patented compounds known as ceragenins or CSAs. These compounds have broad-spectrum activity mimicking those of endogenous antimicrobial peptides such as LL-37. CSAs, however, are not peptides; rather synthetic small molecules that can be manufactured at large scale and are not subject […]. Read More. ...
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An open letter in support of transformative biotechnology and social innovation: SANKO University Innovation Summit in Medicine and Integrative Biology, Gaziantep, Turkey, May 5-7, 2016, Eyüp Saygılı, Alaa Abou-Zeid, Salih Akkın, Eleni Aklillu, İbrahim Barlas, Alexander Borda-Rodriguez, Filiz Boschele, Zafer Çetin, Enes Coşkun, Yavuz Coşkun, Güner Dağlı, Türkan Dai, Collet Dandara, Türkay Dereli, Levent Elbeyli, Laszlo Endrenyi, Can Eyigün, Alexandros Georgakilas, Bircan Günbulut, Kıvanç Güngör, Asım Güzelbey, Can Hekim, Farah Huzair, Sabit Kimyon, Ümit Karakaş, Biaoyang Lin, Adrián LLerena, Collen Masimirembwa, Ruth McNally, Alper Mete, Peşvin Sancar, Sanjeeva Srivastava, Lotte Steuten, Oylum Tanrıöver, David Tyfield, Volkan Töre, Deniz Vuruşkan, Wei Wang, Louise Warnich, Ambroise Wonkam, Yusuf Yıldırım, İsmet Yılmaz, Ahmet Sınav, and Nezih Hekim. ...
ArimiT, otherwise known as Arimistane or Androsta-3,5-Diene-7,17-Dione, is the strongest natural aromatase inhibitor on the market. Derived from 7-keto DHEA, ArimiT demonstrates an incredible ability to suppress estrogen and may increase fat loss and improve immune system function. Additionally, ...
28-norlup-20(29)-en-3beta-hydroxy-17beta-hydroperoxide: antiproliferative triterpene from leaves of Melaleuca ericifolia; structure in first source
chemBlink provides information about CAS # 1338221-87-6, (3alpha,17beta)-4-Chloro-17-methylandrosta-1,4-diene-3,17-diol, molecular formula: C20H29ClO2.
This is a list of androstanes, or androstane derivatives. Androstanol 3α,5α-Androstanol (5α-androstan-3α-ol) - an endogenous ...
Androstanes, Neurosteroids, Pheromones). ...
... s, Androgens and anabolic steroids, Androstanes, Prodrugs). ...
Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion ...
Estrane and pregnane List of androstanes C19H32 Wilson JD (1996). "Role of dihydrotestosterone in androgen action". Prostate ...
They include the androstanes androstadienol, androstadienone, androstenol, and androstenone and the estrane estratetraenol. ... the androstanes dehydroepiandrosterone (DHEA; prasterone), and dehydroepiandrosterone sulfate (DHEA-S; prasterone sulfate), and ...
5α-androstanes". Journal of Pharmacy and Pharmacology. 17 (1): 55-59. doi:10.1111/j.2042-7158.1965.tb07569.x. Buckett, W.R.; ...
Testosterone derivatives can be classified into subgroups including androstanes, estranes (19-norandrostanes), and gonanes (18- ...
... and other 1-dehydrogenated androstanes. The drug has been sold on the Internet as a designer steroid and "dietary supplement". ... Androstanes, Ketones, Prodrugs, All stub articles, Steroid stubs, Genito-urinary system drug stubs). ...
v t e v t e (Androstanes, Human metabolites, Steroid hormones, Testosterone, All stub articles, Steroid stubs, Biochemistry ...
Androstanes, Articles with short description, Short description is different from Wikidata, All set index articles, Chemistry ...
Androstanes, Articles with short description, Short description is different from Wikidata, All set index articles, Chemistry ...
Androgen backdoor pathway List of androgens/anabolic steroids List of neurosteroids § Androstanes List of neurosteroids § ... Androstanes, Hormones of the liver, Human metabolites, Human pheromones, Mammalian pheromones, Neurosteroids, Steroid hormones ...
Androstanes, World Anti-Doping Agency prohibited substances). ...
Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as ...
Androstanes, Human female endocrine system, World Anti-Doping Agency prohibited substances). ...
Androstanes, Glucocorticoids, All stub articles, Steroid stubs). ...
Androstanes, Carbonate esters, Testosterone esters, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ...
Androstanes, Prodrugs, Testosterone esters, Propionate esters, Abandoned drugs, All stub articles, Steroid stubs, Genito- ...
Androstanes, Biomarkers, Hormones of the suprarenal cortex, Ketones, Secondary alcohols, Sex hormones, Steroid hormones, All ...
Androstanes, Bayer brands, Contraception for males, Ketones, Testosterone esters, Undecanoate esters). ...
Androstanes, Human metabolites, Glucuronide esters). ...
Androstanes, Isocaproate esters, Testosterone esters, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ...
Androstanes, Ketones, Testosterone esters, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ...
Androstanes, Hepatotoxins, Prodrugs, Tertiary alcohols, All stub articles, Steroid stubs, Genito-urinary system drug stubs). ...
Androstanes, CYP17A1 inhibitors, Hormonal antineoplastic drugs, Human drug metabolites, Enones, Prostate cancer, 3-Pyridyl ...
Androstanes, Human pheromones, Mammalian pheromones, Neurosteroids). ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Categories: Androstanes Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 1 ...
Androstanes and androstane derivatives which are substituted in any position with one o... more. 13. 47. Details. ... Androstanes. The family of steroids from which the androgens are derived.. 69. 312. Details. ...
19-position substituted (e.g., 19-methylene-androstanes, 10-cyanoestranes, etc.) (Class 552/632) ...
Androstanes D4.808.54 D4.210.500.54 Androstanols D4.808.54.40 D4.210.500.54.40 Androstatrienes D4.808.54.79.229 D4.210.500.54. ...
Androstanes - Preferred Concept UI. M0001109. Scope note. The family of steroids from which the androgens are derived. ...
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Category:Androstanes. Category:Estranes. Category:Estrogensing. and cutting his hair, rolling his eyes. and dramatically ...
Andros- tanes, 19-norandrostanes and their unsaturated analogs. Christ v, klostermann k, opfermann g (1984) routinebestimmung ...
Androstanes have 19 carbons (c19 steroids) and include androgens. The dynamics of steroid hormone production and clearance, it ...
Testosterone cypionate androgen [epc],androgen receptor agonists [moa],androstanes [cs]. Packaging size, 10 ampoules of 1 ml. ...
La testostérone est un stéroïde de la classe des androstanes. La testostérone que vous pourrez dailleurs acheter pour pas cher ...
Androstanes: 8*Androstenes: 4*Finasteride: 1073*turosteride: 2. *17 beta-benzoyl-4-aza-5 alpha-androst-1-ene-3-one: 1 ...
It is an androgen prohormone of 1-testosterone (dihydroboldenone), 1-androstenedione, and other 1-dehydrogenated androstanes. ...
... and other 1-dehydrogenated androstanes. 4 andro, short for 4-androsterone, is a type of chemical classified as a prohormone. ...
For some types, including androstanes, women also had longer than men, anabolic steroid price in pakistan. The detection times ... androstanes), and nandrolone conjugate. (Figure 2) Tables 2 to 4 show the mean detection times for each sex and age group. ( ...
plant steroids are derived from sterols and comprise steroid saponins, steroid alkaloids, pregnanes, androstanes, estranes, ...
... and are known as androstanes. Androstanes are more polar than androstenes, and hence are hygroscopic and water soluble (this is ...
Androstanes D4.808.54 D4.210.500.54 Androstanols D4.808.54.40 D4.210.500.54.40 Androstatrienes D4.808.54.79.229 D4.210.500.54. ...
Androstanes D4.808.54 D4.210.500.54 Androstanols D4.808.54.40 D4.210.500.54.40 Androstatrienes D4.808.54.79.229 D4.210.500.54. ...
Androstanes D4.808.54 D4.210.500.54 Androstanols D4.808.54.40 D4.210.500.54.40 Androstatrienes D4.808.54.79.229 D4.210.500.54. ...
... resulted in both significant impairment of the 17ß-HSD activity and emergence of 3ß-HSD activity towards 5α-androstanes ...
Androstanes D4.808.54 D4.210.500.54 Androstanols D4.808.54.40 D4.210.500.54.40 Androstatrienes D4.808.54.79.229 D4.210.500.54. ...
Author: Ahmad, VU and Basha, APublisher: Springer, immanent Data of Steroid Glycosides: Pregnanes, Androstanes, and ...
This graph shows the total number of publications written about "Steroids, Chlorinated" by people in UAMS Profiles by year, and whether "Steroids, Chlorinated" was a major or minor topic of these publications ...
Androstanes [D04.210.500.054] * Bile Acids and Salts [D04.210.500.105] * Cardanolides [D04.210.500.155] ...
This graph shows the total number of publications written about "Sapogenins" by people in this website by year, and whether "Sapogenins" was a major or minor topic of these publications ...
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50 mg clomid 150 mg clomid androstanes antiestrogen anti estrogen supplements clomid clomid 50mg clomid 150mg clomid cycle one ... androstanes, anti estrogen, anti estrogen supplements, anti-estrogen, antiestrogen, emestane dose, exemestane, exemestane (drug ...
  • Androstanes have 19 carbons (c19 steroids) and include androgens. (guaterhinos.com)
  • Pregnenolone ( P5 ), or pregn-5-en-3β-ol-20-one , is an endogenous steroid and precursor / metabolic intermediate in the biosynthesis of most of the steroid hormones , including the progestogens , androgens , estrogens , glucocorticoids , and mineralocorticoids . (wikipedia.org)
  • For some types, including androstanes, women also had longer than men, anabolic steroid price in pakistan. (quark0ne.org)