Prostate
Heterocyclic Compounds
Androgens
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Molecular Structure
Dehydroepiandrosterone
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Dehydroepiandrosterone Sulfate
Body Composition
Drug and Narcotic Control
Pseudoephedrine
Anabolic Agents
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Designer Drugs
Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.
Writing
Receptors, Steroid
Xenobiotics
Metabolic Detoxication, Drug
Receptors, Cytoplasmic and Nuclear
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Cytochrome P-450 CYP3A
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Pregnenolone Carbonitrile
Ligands
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Androstenols
Logic
The science that investigates the principles governing correct or reliable inference and deals with the canons and criteria of validity in thought and demonstration. This system of reasoning is applicable to any branch of knowledge or study. (Random House Unabridged Dictionary, 2d ed & Sippl, Computer Dictionary, 4th ed)
Psychology, Experimental
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Gene Regulatory Networks
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
Adosterol
Catalysis
Epoxy Compounds
HIV-1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Gene Products, tat
Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.
Stereoisomerism
HIV-2
An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition. It shares serologic reactivity and sequence homology with the simian Lentivirus SIMIAN IMMUNODEFICIENCY VIRUS and infects only T4-lymphocytes expressing the CD4 phenotypic marker.
Drugs, Generic
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Names
Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.
Terminology as Topic
Foramen Ovale, Patent
Transfer of the 1-pro-R and the 1-pro-S hydrogen atoms of ethanol in metabolic reductions in vivo. (1/122)
The transfer of deuterium from [1 R-2H]ethanol and [1 S-2H]-ethanol to reduced metabolites of administered compounds was measured in female rats provided with bile fistulas. Administered cyclohexanone was reduced to cyclohexanol, and in this reduction hydrogen was transferred only from the 1-pro-R position of the ethanol. The deuterium content in the cyclohexanol was about 67% of that in the ethanol. In the reduction of the 17-oxo group in 3beta-hydroxy-5alpha-androstan-17-one, hydrogen was transferred both from the 1-pro-R position and the 1-pro-S position, resulting in degrees of labelling that were about 25% and 2%, respectively, of those in the specific positions of the ethanols. The 1-pro-R and 1-pro-S positions of ethanol contributed about 9% and 5%, respectively, of the 3beta hydrogen in lithocholic acid formed from 3-oxo-5beta-cholanoic acid. The results indicate that alcohol dehydrogenase and aldehyde dehydrogenase do not share a common pool of NAD, and that NADH formed during acetaldehyde oxidation is utilized for reductions in the cytosol to a smaller extent than the NADH formed in the alcohol dehydrogenase reaction. This result supports the concept that aldehyde oxidation is mainly an intramitochondrial process. The relatively extensive utilization of the 1-pro-S hydrogen of ethanol in the reduction of 3-oxo-5beta-cholanoic acid, that is probably NADPH-dependent, indicates that cytosolic NADPH may be produced from malate or isocitrate formed intramitochondrially. (+info)Induction of delta-aminolevulinic acid synthetase in isolated rat liver cells by steroids. (2/122)
The role of steroids in regulation of delta-aminolevulinic acid synthetase has been studied in isolated rat liver cell suspensions under conditions previously shown to support inducation of the enzyme by drugs. Addition of a variety of C-19 and C-21 steroids to cell suspensions resulted, after 4 to 6 hours of incubation, in 2- to 5-fold increase in the activity of delta-aminolevulinic acid synthetase as measured in liver cell homogenates. The increase was prevented by cycloheximide. The most active steroid inducers tested were pregnene or pregnane derivatives with keto or hydroxyl groups at C-3 and C-20; in particular a beta-hydroxyl group at C-20 enhanced activity. These C-21 steroids at optimal initial concentrations caused 3- to 5-fold induction over 4 hours. A number of C-19 androstene and androstane compounds caused 2- to 3-fold inducation over the same period. Hydrocortisone had no effect. For a variety of androstane and pregnane derivatives, inducation by 5alphaH steroids was as great as or greater than that by 5betaH compounds, in contrast to previous findings in chick embryo liver. Induction of delta-aminolevulinic acid synthetase by steroids in isolated liver cells was shown to be subject to feedback repression by hemin. (+info)Regulation and substrate specificity of a steroid sulfate-specific hydroxylase system in female rat liver microsomes. (3/122)
The sulfate-specific hydroxylase system in liver microsomes from rats has been investigated with respect to its substrate specificity. Eighteen different C18, C19, C21, and C27 steroid sulfates and the coresponding free steroids have been incubated with microsomal preparations from male and female rats. The sulfate-specific system was only present in preparations from female rats and primarily catalyzed hydroxylation in position 15beta but also in position 7beta. In contrast to this, male liver microsomes were more efficient than female liver microsomes in hydroxylating free steroids; these were hydroxylated in positions 2alpha,2beta,6alpha,6beta,7alpha,7beta,16alpha, and 18. The sulfate-specific hydroxylase system in female liver microsomes was found to have rigid requirements c concerning the structure of ring D in the substrate molecule; only 17beta-sulfates (C18 and C19 steroids) and 21-sulfates (C21 steroids) were hydroxylated. Less rigid criteria, however, exist concerning the structure of ring A. The following K-m values were determined for microsomal 15beta-hydroxylation: 5alpha-androstane-3alpha,17beta-diol disulfate, 17.2 muM; 5beta-androstane-3alpha,17beta-diol disulfate, 16muM;5alpha-androstane-3alpha,17beta-diol 17-sulfate, 26 muM; and estradiol 17-sulfate, 181 muM. Some of the regulatory mechanism controlling the activity of the sex-specific 15beta-hydroxylase system also have been studied and compared to the mechanism controlling the activities of the less specific 2alpha-, 7alpha-, and 18-hydroxylase systems active on 5alpha-[4-14C]androstane-3alpha,17beta-diol. Biliary drainage did not affect the 15beta-hydroxylase activity, whereas the 2alpha- and 7alpha-hydroxylase activities decreased.. (+info)Antiarrhythmic, haemodynamic and metabolic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one hydrochloride in greyhounds following acute coronary artery ligation. (4/122)
1 The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. 2 ORG6001 administered either intravenously (2-10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. 3 In dogs pretreated with ORG6001, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. 4 Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. 5 These results suggest that ORG6001 may possess distinct advantages over presently-used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction. (+info)Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. (5/122)
Methoxychlor, a structural analog of the DDT pesticide, was previously shown to induce rat hepatic CYP2B and -3A mRNAs and the corresponding proteins [J Biochem Mol Toxicol 1998;12:315-323], Additionally, methoxychlor was found to activate the constitutive androstane receptor (CAR) system and induce CYP2B6 (J Biol Chem 1999;274:6043-6046), suggesting a mechanism for methoxychlor-mediated cytochrome P450 (P450) 2B induction. However, it has not been established whether CAR activation and P450 induction was due to methoxychlor per se and/or due to its metabolites. Also, a possible link between the estrogenic potency of methoxychlor metabolites and CAR activation or P450 induction was not investigated. The current study explores the ability of methoxychlor and its metabolites to activate CAR and whether their potency of CAR activation correlates with their respective estrogenicity. Methoxychlor and its metabolites [mono-OH-M [1,1,1-trichloro-2 (4-hydroxyphenyl)-2'-(4-methoxyphenyl)ethane]; bis-OH-M [1,1,1-trichloro-2,2'-bis(4-hydroxyphenyl)ethane]; ring-OH-M [1,1,1-trichloro-2(4-methoxyphenyl)-2'-(3-hydroxy-4-methoxyphenyl)ethane]; and tris-OH-M [1,1,1-trichloro-2(4-hydroxyphenyl)-2'-(3,4-dihydroxyphenyl)ethane]] were found to be potent activators of CAR. Dose response curves indicated that tris-OH-M is a more potent CAR activator than methoxychlor, mono-OH-M, and bis-OH-M. Since tris-OH-M is a much weaker estrogen receptor-alpha agonist than mono-OH-M and bis-OH-M, it seems that estrogenicity is not a significant factor in CAR activation. These findings indicate that alteration of methoxychlor-benzene rings, i.e., generation of phenolic constituents, does not appreciably alter CAR activation and suggest that a common structural motif in the methoxychlor class of compounds controls CAR activation. Studies are needed to identify the structural motif necessary for CAR activation and CYP2B induction. (+info)Local anaesthetic and antiarrhythmic properties of an aminosteroid: 3alpha-dimethyl-amino-5alpha-androstan-2beta-ol-17-one (Org. NA 13). (6/122)
1. The aminosteroid Org. NA13 (3alpha-dimethylamino-5alpha-androstan-2beta-ol-17-one) was shown to be a more potent local anaesthetic than lignocaine in rats and guinea-pigs. 2. Experimental arrhythmias induced in mice by chloroform, in rats by aconitine and in dogs by coronary artery ligation were corrected by Org. NA13 at doses from 10 to 50 mg/kg intravenously. 3. In contrast to lignocaine, other local anaesthetics and beta-adrenoceptor blocking drugs, Org. NA 13 did not show any activity against the arrhythmias induced by ouabian in dogs. 4. The acute toxicity in whole animals and myocardial toxicity in the rabbit isolated atrium appeared to be less than that observed with lignocaine. (+info)Steroid induction of delta-aminolevulinic acid synthase and porphyrins in liver. Structure-activity studies and the permissive effects of hormones on the induction process. (7/122)
Quantitative aspects and structure-activity relationships of the inducing effects of natural steroids on delta-aminolevulinic acid (ALA) synthase and porphyrins have been investigated in monolayer cultures of chick embryo liver cells maintained in a serum-free medium as well as in the chick embryo liver in ovo. Many 5 alpha and 5 beta metabolites of neutral C-19 and C-21 hormones and hormone precursors stimulated porphyrin formation and ALA-synthase induction in the cultured liver cells as we have previously described. In these inducing actions a number of 5 beta epimers (A:B cis) were found to be more potent than their corresponding 5 alpha epimers (A:B trans). The structure-activity relationship between 5 beta and 5 alpha steroid epimers with respect to ALA-synthase induction in culture was also found to prevail with respect to induction of this enzyme in chick embryo liver in ovo. Hemin in concentrations of 2 x 10(-7) M inhibited steroid induction of porphyrin formation, and CaMgEDTA enhanced the responsiveness of the cultured liver cells to steroids by approximately 10 times. The addition of insulin, or insulin plus hydrocortisone or insulin plus hydrocortisone plus triiodothyronine, was important for the maintenance of protein synthesis and essential for maximal expression of the ability of steroids to induce porphyrins and ALA-synthase in the "permissive" effect which insulin, hydrocortisone, and triiodothyronine exert on allylisopropylacetamide induction of porphyrins and ALA-synthase also extends to the induction process which is elicited by natural steroids. These findings also strongly suggest that the regulation of hepatic porphyrin-heme biosynthesis by endogenous as well as exogenous chemicals is significantly influenced by the internal hormonal milieu. (+info)Stereochemical aspects of the interaction between steroidal diamines and DNA. (8/122)
A complete series of stereoisomeric quaternised diaminoandrostanes, differing in their stereochemistry at the 3,5 and 17 positions, has been examined for effects on the thermal denaturation of calf thymus DNA and for the ability to remove and reverse the supercoiling of closed circular duplex PM2 DNA. In both types of test the eight isomers rank in the same order of effectiveness. The preferred stereochemistry for the quaternary substituents at positions 3 and 17 is beta; of these the orientation of the 17- substituent is more critical. Folding of the steroid skeleton between the A and B rings, as in 5beta-androstanes, diminishes effectiveness but does not necessarily abolish the effect on supercoiling. The over-riding importance of the C-D ring end of the steroid nucleus bearing a 17beta-amino substituent is confirmed by a comparison of the effects of five mon-amino androstanes. Relative helix=unwinding angles per bound steroidal diamine molecule have been determined for four of the isomers; for three 17beta compounds the estimated values are similar to that previously reported for irehdiamine A. For a fourth isomer the angle is 0.22 times that of ethidium, the lowest yet determined for any DNA-binding drug. The results lend further support to the argument that intercalation can be reled out, and alternative models for the binding mechanism are discussed. (+info)
China 17beta-Hydroxy-2alpha-Methyl-5alpha-Androstan-3-One Propionate - China 17beta-Hydroxy-2alpha-Methyl-5alpha-Androstan-3-,...
China High Quality Steroid Powder Androsta-1, 4-diene-3, 17-dione(897-06-3) - China Androsta-1 4-diene-3 17-dione, anabolic...
CAS No.1420-49-1,Androsta-3,5-diene-7,17-dione Suppliers
3alpha-Hydroxy-2beta-(piperidin-1-yl)-5alpha-androstan-17-one
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Recently Published Reviews Highlight the Potential Utility of Ceragenins in the Fight Against Biofilm Mediated and Multidrug...
9-fluoro-6-(4-fluorobenzyl)-2,3-dihydro[1,3]thiazolo[3,2:1,2]pyrimido[5,4-b]indol-5(6H)-one | C19H13F2N3OS - PubChem
Klonēšana - Vikipēdija
PPT - Abstract PowerPoint Presentation - ID:2216955
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C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells<...
5alpha-Androstan-3-one, 17beta-hydroxy-1alpha,17-dimethyl- (CAS 2881-21-2) Market Research Report 2018
16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one
Summary Report | CureHunter
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Testosterone- Mens health - Janella Purcell
藤原 好恒(大学院理学研究科)
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TRC | Details of CAS = , ChemicalName = 3-(2-Deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one-13C3, synonym =...
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Gestodene
Indian Patents. 206809:A PROCESS FOR PREPARING RANDOM PROPYLENE COPOLYMERS CONTAINING COPOLYMERIZED C2-C10-ALK-1-ENES
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5α)-Androsta-2,16-dien-17-yl acetate - Registration Dossier - ECHA
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Constitutive androstane receptor - Wikipedia
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Mice model becomes surrogate for human prostate ( Another importance of stem cells comes ...)
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testosterone-4 : Information on Uses, Dosage & Side Effects
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28-norlup-20(29)-en-3beta-hydroxy-17beta-hydroperoxide
Summary Report | CureHunter
CAS # 1338221-87-6, (3alpha,17beta)-4-Chloro-17-methylandrosta-1,4-diene-3,17-diol
4-Hydroxyestrone
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Androstenediol
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
Cortisol
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
5α-Dihydroprogesterone
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
11-Deoxycortisol
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
17α-Hydroxypregnenolone
Androstanes: 3α-Androstanediol. *3α-Androstenol. *7-Keto-DHEA. *7α-Hydroxy-DHEA ...
17β-Hydroxysteroid dehydrogenase
Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion ...
Androstane
Estrane and pregnane List of androstanes C19H32 Wilson JD (1996). "Role of dihydrotestosterone in androgen action". Prostate ...
Neurosteroid
They include the androstanes androstadienol, androstadienone, androstenol, and androstenone and the estrane estratetraenol. ... the androstanes dehydroepiandrosterone (DHEA; prasterone), and dehydroepiandrosterone sulfate (DHEA-S; prasterone sulfate), and ...
1-Androsterone
... and other 1-dehydrogenated androstanes. The drug has been sold on the Internet as a designer steroid and "dietary supplement". ...
Constitutive androstane receptor
Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as ...
Pregnenolone (medication)
In contrast to the androstanes, 50 or 100 mg oral pregnenolone has been found to significantly and in fact "strongly" increase ...
List of androstanes
This is a list of androstanes, or androstane derivatives. Androstanol 3α,5α-Androstanol (5α-androstan-3α-ol) - an endogenous ...
3-Keto-5α-abiraterone
... , also known as 17-(3-pyridyl)-5α-androst-16-en-3-one, is an active metabolite of abiraterone acetate that has been found to possess androgenic activity and to stimulate prostate cancer progression.[1][2] It is formed as follows: abiraterone acetate to abiraterone by esterases; abiraterone to Δ4-abiraterone by 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase; and Δ4-abiraterone to 3-keto-5α-abiraterone by 5α-reductase.[1][2] 3-Keto-5α-abiraterone may counteract the clinical effectiveness of abiraterone acetate, and so inhibition of its formation using the 5α-reductase inhibitor dutasteride is being investigated as an adjunct to abiraterone acetate in the treatment of prostate cancer.[1][2] ...
Chlorodehydromethyltestosterone
Androstanes. *Hepatotoxins. *Ketones. *Organochlorides. *Science and technology in East Germany. *World Anti-Doping Agency ...
4-Hydroxytestosterone
Androstanes. *Aromatase inhibitors. *Exercise physiology. *Drugs in sport. *World Anti-Doping Agency prohibited substances ...
Methyl-1-testosterone
Androstanes. *Hepatotoxins. *World Anti-Doping Agency prohibited substances. *Steroid stubs. *Genito-urinary system drug stubs ...
Androstanolone
Androstanes. *Estrogens. *GABAA receptor positive allosteric modulators. *Ketones. *Testosterone. *World Anti-Doping Agency ...
Danazol
Androstanes. *Antiestrogens. *Antigonadotropins. *Cholesterol side-chain cleavage enzyme inhibitors. *CYP17A1 inhibitors. * ...
Androisoxazole
... (brand names Androxan, Neo-Ponden, Neo-Pondus), also known as 17α-methyl-5α-androstano[3,2-c]isoxazol-17β-ol, is an orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of dihydrotestosterone (DHT) that is marketed in Spain and Italy.[1][2][3][4] It is closely related to stanozolol, differing only in having an isoxazole instead of pyrazole ring fused to the A ring,[4] and is also related to furazabol, prostanozol, and danazol. ...
Metenolone enanthate
... , or methenolone enanthate, sold under the brand names Primobolan Depot and Nibal Injection, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure.[2][3][4][5][6][7] It is given by injection into muscle.[6] Although it was widely used in the past, the drug has mostly been discontinued and hence is now mostly no longer available.[5][6][3] A related drug, metenolone acetate, is taken by mouth.[6] Side effects of metenolone enanthate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.[6] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[6][8] It has moderate anabolic effects and weak androgenic effects, as well as no estrogenic effects or risk of liver damage.[6][8] Metenolone enanthate is a metenolone ...
Testosterone phenylpropionate
Androstanes. *Testosterone esters. *Genito-urinary system drug stubs. *Steroid stubs. Hidden categories: *Chemical pages ...
Drostanolone propionate
The principal clinical indication of drostanolone propionate in the United States as well as international markets was the treatment of advanced inoperable breast cancer in women.[1]. Hormonal treatment is part of the complex therapy for some kind of tumors, particularly the ones associated with hormone-active tissues like breast or prostate cancer. Some types of breast cancer cells, expressing estrogen receptors (called ER+ cancers), use estrogen for their growth and dissemination. That is why drugs that block estrogen receptors or decrease their expression on the cell membrane, antiestrogens, could limit the tumor spread and size. Drostanolone propionate has been FDA approved[7] as an antiestrogenic drug for the treatment of breast cancer. By the time of its release, there were not many alternatives for patients suffering from breast cancer and drostanolone propionate was a revolution for these patients. As it has lower androgenic rate compared to testosterone, the risk of virilization is much ...
Stenbolone
Androstanes. *Enones. *World Anti-Doping Agency prohibited substances. Hidden categories: *Chemical pages without DrugBank ...
Dutasteride
... belongs to a class of drugs called 5α-reductase inhibitors, which block the action of the 5α-reductase enzymes that convert testosterone into DHT.[36] It inhibits all three forms of 5α-reductase, and can decrease DHT levels in the blood by up to 98%.[1][37][38] Specifically it is a competitive, mechanism-based (irreversible) inhibitor of all three isoforms of 5α-reductase, types I, II, and III (IC50 values are 3.9 nM for type I and 1.8 nM for type II).[1][37][39][40] This is in contrast to finasteride, which is similarly an irreversible inhibitor of 5α-reductase[40][41] but only inhibits the type II and III isoenzymes.[37] As a result of this difference, dutasteride is able to achieve a reduction in circulating DHT levels of up to 98%, whereas finasteride is able to achieve a reduction of only 65 to 70%.[38][2][36][42] In spite of the differential reduction in circulating DHT levels, the two drugs decrease levels of DHT to a similar extent of approximately 85 to 90% in the ...
Methandriol
Androstanes. *Diols. *Hepatotoxins. *World Anti-Doping Agency prohibited substances. Hidden categories: *Articles with changed ...
4-Dehydroepiandrosterone
Androstanes. *Ketones. *Steroid stubs. Hidden categories: *Chemical articles with multiple compound IDs ...
Quinbolone
Most orally administered anabolic steroids function by having an alkylated 17α-carbon atom, which prevents first-pass metabolism by the liver.[citation needed] This approach however results in the AAS having hepatotoxicity.[citation needed] Quinbolone is not 17α-alkylated; instead it has increased oral bioavailability due to its cyclopentenyl ether group.[citation needed] After ingestion, the inactive quinbolone is transformed into boldenone.[1] Quinbolone itself has very few androgenic effects, and most of what it does have are a result of its conversion to boldenone and its metabolites.[1][5][additional citation(s) needed] Because of high doses necessary for androgenic effects, cost and inconvenience meant that quinbolone never proved to be commercially successful, and its clinical applications were fulfilled by alternative, more effective, AAS.[citation needed] Its illicit usage in bodybuilding and athletics likewise proved limited, though drug tests are still used to detect its metabolites ...
Anabolic steroid
Steroids; Androstanes; Estranes. Clinical data. Drugs.com. Drug Classes. External links. MeSH. D045165. ...
Testosterone
Androstanes. *Estrogens. *GABAA receptor positive allosteric modulators. *Hormones o the testis. *Hormones o the ovary ...
List of androstanes - Wikipedia
Androstanes - Phenotypes | CTD
4-Hydroxyestrone - Wikipedia
Androstenediol - Wikipedia
Download Spectroscopic Data Of Steroid Glycosides Pregnanes Androstanes And Miscellaneous Volume 5 2006
... by Herman 3.6 ... Whether you are requested the download spectroscopic data of steroid glycosides pregnanes androstanes and or not, if you do ... In Act I, Scene 1, of King Lear, what exists download spectroscopic data of steroid glycosides pregnanes androstanes pleasure? ... currently, you are correctly in our download spectroscopic data of steroid glycosides pregnanes androstanes. The tool way has ...
RCSB PDB - ASD Ligand Summary Page
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
RCSB PDB - TES Ligand Summary Page
C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells<...
C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells. / Moreira ... C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells. European ... title = "C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells", ... T1 - C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells ...
Anabolic steroids in sport: biochemical, clinical and analytical perspectives
Patent US5795880 - Method and composition for treating obesity and related disorders in animals ... - Google Patents
16-substituted androstanes and 16-substituted androstenes. US5006517 *. Jul 24, 1989. Apr 9, 1991. Progenics, Inc.. Treatment ... Derivatives of DHEA, such as 16-substituted androstanes and 16-substituted androstenes, are described in U.S. Pat. No. ... is selected from the group consisting of 16-substituted androstanes, 16-substituted androstenes, 17 hydroxy-steroids, α-HET, β- ...
CELLULOSE CAPSULES AND METHODS FOR MAKING THEM - UNIVERSITY OF IOWA RESEARCH FOUNDATION
Mounting behavior of female guinea pigs after prenatal and adult administration of the propionates of testosterone,...
MEDLINE - Resultado p gina 1
2011 - Proposed Rule: Classification of Two Steroids, Prostanozol and Methasterone, as Schedule III Anabolic Steroids Under the...
Molecules | Free Full-Text | Plants are Capable of Synthesizing Animal Steroid Hormones | HTML
steroid : Wikis (The Full Wiki)
Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR.
CoMFA models for androstanes. A 5?-Androstan-3?-ol (pIC50?=?6.1) shown with the steric component of the CoMFA model. Green ... Among the androstanes, 6 out of 11 compounds were predicted correctly as activators and 9 out of 14 compounds were classified ... CoMSIA models for androstanes. A - 17?-dihydroandrosterone (pIC50?=?5.38) with the steric component of the CoMSIA model. Blue ... A. 4D-QSAR for androstanes showing the active conformation of 5?-Androstan-3?-ol, B 4D-QSAR for pregnanes showing the active ...
17β-Hydroxysteroid dehydrogenase - Wikipedia
Androstenols | Harvard Catalyst Profiles | Harvard Catalyst
Dihydrotestosterone | Harvard Catalyst Profiles | Harvard Catalyst
Advanced Search Results - Public Health Image Library(PHIL)
4,5-epoxy-17-hydroxy-2-methylsulfonyl-3-androstanone
Summary Report | CureHunter
US20070141933A1 - Aqueous polyolefin dispersions for textile impregnation
- Google Patents
Sciencemadness Discussion Board - The Short Questions Thread (4) - Powered by XMB 1.9.11
Testosterone / testosterone NDA 076744 global drug patent coverage, generic alternatives and manufacturers
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British Organic Geochemical Society (BOGS) meetings at Plymouth - University of Plymouth
Steroids
US5554603A - Orally active derivatives of 1,3,5(10)-estratriene
- Google Patents
Publications - Uni Oldenburg
Phenobarbital Meets Phosphorylation of Nuclear Receptors | Drug Metabolism & Disposition
Later, androstanes were found to repress constitutive activity of CAR in cell-based assays, which became the basis of "CAR" to ... Although androstanes are useful to identify CAR activators in cell-based reactivation assays (Sueyoshi et al., 1999), there is ... no biologic significance to CAR being repressed by androstanes. In addition, an androstane also activates the pregnane X ...
Steroids3
- Androstanes generally buy online steroids with credit card and increase your how would like to build muscle and loss fat. (reed-electronics.com)
- Androstanes Fused-Ring Compounds Steroids. (instructure.com)
- Steroids with 21 carbon atoms are known as pregnanes, whereas those containing 19 and 18 carbon atoms are known as androstanes and estranes, respectively. (letstalkacademy.com)
Estranes3
- 100-fold higher affinity for estranes over androstanes. (wikipedia.org)
- Androstanes which are lacking carbon-19 are ESTRANES. (bireme.br)
- For example, estranes and androstanes etc. (alevelbiology.co.uk)
Pregnanes7
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- Antibodies used were raised against pregnanediol (20 alpha-OH-pregnanes), 20-oxo-pregnanes, epiandrosterone (17-oxo-androstanes), and total estrogens. (biomedsearch.com)
- HPLC separation of immunoreactive fecal metabolites indicated the presence of estrone, estradiol-17beta, and several 17-oxo-androstanes, 20 alpha-OH-pregnanes, and 20-oxo-pregnanes. (biomedsearch.com)
- Pregnanes, androstanes, and miscellaneous -- v. 6. (liverpool.ac.uk)
- Therefore, several substances including substituted estradiols, pregnanes, androstanes, plus some artificial estrogens had been examined for both stimulatory and inhibitory activity within this assay (Fig. (fak-signaling.com)
Androstenes1
- Androstanes are more polar than androstenes , and hence are hygroscopic and water soluble (this is inherently interrelated to increased efficacy at receptor sites via increased membrane permeability ). (alpha-dream.com)
Androgens2
- Androstanes (C 19 H 32 ) are also from the steroid family that androgens are derived from, the most famous androgen being testosterone. (reagent.co.uk)
- We have identified a bacterial gene cluster responsible for steroid-17,20-desmolase which converts host glucocorticoids to androstanes and androgens. (uiuc.edu)
Estrogens2
- Progesterone metabolites were also reliable indicators of pregnancy, whereas 17-oxo-androstanes and estrogens were basal throughout gestation. (biomedsearch.com)
- Pregnane metabolites were reliable indicators of the corpus luteum and pregnancy, whereas fecal 17-oxo-androstanes and estrogens were indicators of the follicular phase. (biomedsearch.com)
Agonists1
- CAR has previously been shown to be an apparently constitutive transactivator, and this constitutive activity is inhibited by androstanes acting as inverse agonists. (asm.org)
Compounds1
- These enzymes convert the saponins pregnanowe compounds (C-21) and androstanes (C-19), are substrates for the synthesis of testosterone and androsterone. (bodynutritionuk.co.uk)
Saponins1
- But it doesn't increase test via androstanes or saponins. (gymtraining.org)
Derivatives2
- This is a list of androstanes, or androstane derivatives. (wikipedia.org)
- Reduction of 2-Nitro-5α-cholestan-3-one, Its Enol Tautomer and 2-Nitro-5α-cholest-2-en-3-amine Derivatives. (cas.cz)
Hydroxyl1
- Unsaturated androstanes which are substituted with one or more hydroxyl groups in any position in the ring system. (harvard.edu)
Precursor1
- It is the main precursor to pheromones, a lot of which are adrostenes, androstanes, and androstadienes. (friarsroast.com)
DHEA1
- En el presente trabajo se confirma la presencia de polipéptidos y esteroides conjugados -como el factor de crecimiento epidérmico (FCE), el sulfato de dehidroepiandrosterona (S-DHEA) y el androstano-3Ó, 17ß-diol glucurónido (3Ó-Adiol G)- a veces en concentraciones muy elevadas con respecto a los niveles encontrados simultáneamente en el plasma circulante. (bvsalud.org)
Effects1
- Primary active ingredient (17a-methyl-etioallocholan-17b-ol-3-hydroxyimine) was first described by Z. Cekan and B. Pelc, Effects of 1-alkyl substitution on the biological action in a series of androstanes. (anabolicminds.com)
Chemical1
- Chemical structure of the natural AAS testosterone (androst-4-en-17β-ol-3-one). (wikipedia.org)
Studies1
- Previous studies demonstrated that P. lanosocoeruleum KCH 3012 metabolizes androstanes to the corresponding lactones with high yield. (biomedcentral.com)