Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
The family of steroids from which the androgens are derived.
Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
An enzyme that catalyzes the dehydration of 1,2-propanediol to propionaldehyde. EC 4.2.1.28.
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
A uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood.
A human liver tumor cell line used to study a variety of liver-specific metabolic functions.
A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity.
Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
A generic grouping for dihydric alcohols with the hydroxy groups (-OH) located on different carbon atoms. They are viscous liquids with high boiling points for their molecular weights.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
A nuclear transcription factor. Heterodimerization with PPAR GAMMA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES.
Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.
An azo dye with carcinogenic properties.
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Unsaturated androstanes which are substituted with one or more hydroxyl groups in any position in the ring system.
Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
A subfamily of nuclear receptors that regulate GENETIC TRANSCRIPTION of a diverse group of GENES involved in the synthesis of BLOOD COAGULATION FACTORS; and in GLUCOSE; CHOLESTEROL; and FATTY ACIDS metabolism.
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
Immunoglobulin heavy chain gene exons coding for the hinge region of the heavy chains between the first constant region (on the FAB FRAGMENTS) and the second constant region (on the FC FRAGMENTS).
A plant genus of the family ASCLEPIADACEAE. Members contain steroidal glycosides and cytotoxic phenanthroindolizidine N-oxide alkaloids.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
A concave exterior region on some POLYCYCLIC AROMATIC HYDROCARBONS that have three phenyl rings in a non-linear arrangement.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
An organic anion transporter found in human liver. It is capable of transporting a variety organic anions and mediates sodium-independent uptake of bile in the liver.
Enzymes which transfer sulfate groups to various acceptor molecules. They are involved in posttranslational sulfation of proteins and sulfate conjugation of exogenous chemicals and bile acids. EC 2.8.2.
DITERPENES with three LACTONES and a unique tert-butyl group, which are found in GINKGO plants along with BILOBALIDES.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
A transcription factor that partners with ligand bound GLUCOCORTICOID RECEPTORS and ESTROGEN RECEPTORS to stimulate GENETIC TRANSCRIPTION. It plays an important role in FERTILITY as well as in METABOLISM of LIPIDS.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Gated transport mechanisms by which proteins or RNA are moved across the NUCLEAR MEMBRANE.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.
The simultaneous or sequential binding of multiple cell surface receptors to different ligands resulting in coordinated stimulation or suppression of signal transduction.
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and THYROID HORMONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in the transcriptional activation of chromatin regions.
A subtype of RETINOIC ACID RECEPTORS that are specific for 9-cis-retinoic acid which function as nuclear TRANSCRIPTION FACTORS that regulate multiple signaling pathways.
The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.
Derivatives of propylene glycol (1,2-propanediol). They are used as humectants and solvents in pharmaceutical preparations.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A species of gram-negative bacteria causing URINARY TRACT INFECTIONS and SEPTICEMIA.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
A bile pigment that is a degradation product of HEME.
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
A cell line derived from cultured tumor cells.
Established cell cultures that have the potential to propagate indefinitely.
Experimentally induced tumors of the LIVER.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Unsaturated androstane derivatives which are substituted with two hydroxy groups in any position in the ring system.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Compounds of the general formula R-O-R arranged in a ring or crown formation.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Unsaturated derivatives of PREGNANES.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).
Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Compounds which restore enzymatic activity by removing an inhibitory group bound to the reactive site of the enzyme.
Compounds consisting of two or more fused ring structures.
Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.
Five-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
4-carbon straight chain aliphatic hydrocarbons substituted with two hydroxyl groups. The hydroxyl groups cannot be on the same carbon atom.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.
An enzyme that catalyzes the deamination of ethanolamine to acetaldehyde. EC 4.3.1.7.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
Steroids with methyl groups at C-10 and C-13 and a branched 8-carbon chain at C-17. Members include compounds with any degree of unsaturation; however, CHOLESTADIENES is available for derivatives containing two double bonds.
A nucleoside consisting of the base guanine and the sugar deoxyribose.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).
Hydrocarbons with more than one triple bond; or an oxidized form of POLYENES. They can react with SULFUR to form THIOPHENES.
Tumors or cancer of the LIVER.
Inorganic or organic salts and esters of boric acid.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The characteristic three-dimensional shape of a molecule.
A plant genus of the family PEDALIACEAE. Members contain harpagoside.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The rate dynamics in chemical or physical systems.
A plant genus of the family ASTERACEAE. Members contain hinesol and atractylon. Atractylodes rhizome is Byaku-jutsu. A. lancea rhizome is So-jutsu.
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
Any of the compounds derived from a group of glycols or polyhydroxy alcohols by chlorine substitution for part of the hydroxyl groups. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.
A genus of gram-negative, rod-shaped enterobacteria that can use citrate as the sole source of carbon.
A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)
The rotation of linearly polarized light as it passes through various media.
Organic silicon derivatives used to characterize hydroxysteroids, nucleosides, and related compounds. Trimethylsilyl esters of amino acids are used in peptide synthesis.
Organic compounds containing a carbonyl group in the form -CHO.
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Astatine. A radioactive halogen with the atomic symbol At, atomic number 85, and atomic weight 210. Its isotopes range in mass number from 200 to 219 and all have an extremely short half-life. Astatine may be of use in the treatment of hyperthyroidism.
A halogen with the atomic symbol Br, atomic number 36, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.
Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Isomeric forms and derivatives of hexanol (C6H11OH).
Carcinogenic substances that are found in the environment.
Compounds, either natural or synthetic, which block development of the growing insect.
Organic compounds containing a BENZENE ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of NUCLEIC ACIDS to BENZOPYRENES and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.
An alkylating agent that forms DNA ADDUCTS at the C-8 position in GUANINE, resulting in single strand breaks. It has demonstrated carcinogenic action.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
Addition of hydrogen to a compound, especially to an unsaturated fat or fatty acid. (From Stedman, 26th ed)
The protein components of enzyme complexes (HOLOENZYMES). An apoenzyme is the holoenzyme minus any cofactors (ENZYME COFACTORS) or prosthetic groups required for the enzymatic function.
... , or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous ... 5α-androstane-3β,17β-diol). Derivatives and analogues of androstenediol, such as the 17α-substituted methandriol (17α- ... is a naturally occurring androstane steroid. It is closely related structurally to androstenedione (A4; androst-4-ene-3,17- ... 43-. ISBN 978-3-540-33120-9. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and ...
5β-androstane-3α,17β-diol; etiocholane-3α,17β-diol) - an endogenous intermediate to epiandrosterone 3β-Etiocholanediol (5β- ... androstane-3β,17β-diol; etiocholane-3β,17β-diol) - an endogenous intermediate to epietiocholanolone Androstanediol ... Etiocholanediol (5β-androstanediol) may refer to: 3α-Etiocholanediol ( ...
5α-Androstane-3β,17β-diol. 17 5β-Androstane-3α,17β-diol. 5 ... Chr 17: 7.61 - 7.63 Mb. Chr 11: 69.61 - 69.62 Mb. PubMed search ... 25 (3): 374-88. doi:10.1210/er.2003-0016. PMID 15180949.. *^ a b c d e f g h i Winters SJ, Huhtaniemi IT (25 April 2017). Male ... 44-. ISBN 978-1-4511-4847-3.. *^ a b c Hammond GL, Bocchinfuso WP (1996). "Sex hormone-binding globulin: gene organization and ... ISBN 978-3-319-53298-1.. *^ Becker K, Bilezikian JP, Bremner WJ, Hung W, Kahn CR (24 April 2001). Principles and Practice of ...
... is a synthetic androstane steroid and a derivative of testosterone. It is specifically the combined derivative of 5α- ... 5α-DHET, also known as 5α-dihydro-17α-ethynyltestosterone (17α-ethynyl-DHT) as well as 17α-ethynyl-5α-androstan-17β-ol-3-one or ... Ahlem C, Kennedy M, Page T, Bell D, Delorme E, Villegas S, Reading C, White S, Stickney D, Frincke J (February 2012). "17α- ... 38 (3): 243-62. doi:10.1016/0039-128X(81)90061-1. PMID 7197818. S2CID 2702353. Cherkasov A, Ban F, Santos-Filho O, Thorsteinson ...
39 (3): 291-7. doi:10.1016/0010-7824(89)90061-9. PMID 2714089. Peters AJ, Wentz AC, Kazer RR, Jeyendran RS, Chatterton RT (1995 ... Anordiol, or anordriol, also known as 2α,17α-diethynyl-A-nor-5α-androstane-2β,17β-diol, is a synthetic steroid-like mixed ... 545-. ISBN 978-3-642-60107-1. Chatterton RT, Berman C, Walters NN (1989). "Anti-uterotrophic and folliculostatic activities of ... 52 (3): 195-202. doi:10.1016/0010-7824(95)00151-y. PMID 7587192. v t e v t e. ...
11 (3): 537-45. doi:10.1002/1097-0142(195805/06)11:3. 3.0.co;2-w. PMID 13523561. v t e v t e v t e. ... Clinton, R.; Neumann, H.; Laskowski, S.; Christiansen, R. (1957). "Notes - Esters of 17α-Ethinyl-androstane-3β,17β-diol and 17 ... Ethandrostate, also known as ethinylandrostenediol 3β-cyclohexanepropionate, is a synthetic steroidal estrogen and ester of ... 17β-diol". The Journal of Organic Chemistry. 22 (4): 473-475. doi:10.1021/jo01355a627. ISSN 0022-3263. Olson KB, Frawley TF, ...
Handa, R. J.; Weiser, M. J.; Zuloaga, D. G. (2009). "A Role for the Androgen Metabolite, 5α-Androstane-3β,17β-Diol, in ... 40 (3): 302-15. doi:10.1002/(SICI)1097-4695(19990905)40:3. 3.0.CO;2-7. PMID 10440731. Weinstock M, Matlina E, Maor GI, Rosen H ... 10 (3): 239-250. doi:10.1038/sj.mp.4001643. PMID 15685252. Otmishi, Peyman; Gordon, Josiah; El-Oshar, Seraj; Li, Huafeng; ... 25 (3-4): 132-49. doi:10.1016/j.yfrne.2004.09.001. PMID 15589266. S2CID 41983825. Detillion CE, Craft TK, Glasper ER, ...
"5alpha-Androstane-3beta,17beta-diol (3beta-diol), an estrogenic metabolite of 5alpha-dihydrotestosterone, is a potent modulator ... 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth". Proceedings of the National Academy of Sciences of ... Huang, Q; Zhu, H; Fischer, D; Zhou, J (2008). "An estrogenic effect of 5α-androstane-3β, 17β-diol on the behavioral response to ... Handa, R. J.; Weiser, M. J.; Zuloaga, D. G. (2009). "A Role for the Androgen Metabolite, 5α-Androstane-3β,17β-Diol, in ...
"Inhibition of androstenediol-dependent LNCaP tumour growth by 17alpha-ethynyl-5alpha-androstane-3alpha, 17beta-diol (HE3235)". ... is a synthetic androstane steroid and a 17α-substituted derivative of 3α-androstanediol which was never marketed. It was under ... 17beta-diol, its delta 5-analog and derivatives". Proc. Soc. Exp. Biol. Med. 92 (2): 404-8. doi:10.3181/00379727-92-22493. PMID ... 17α-Ethynyl-3α-androstanediol itself shows very low affinity for steroid receptors, including the AR, ERα, ERβ, PR, and GR, and ...
17beta-diol, its delta 5-analog and derivatives". Proc. Soc. Exp. Biol. Med. 92 (2): 404-8. doi:10.3181/00379727-92-22493. PMID ... 17α-Ethynyl-3β-androstanediol shows high affinity for the estrogen receptors in vitro (IC50 values of 16 nM for ERα and 126 nM ... 17α-Ethynyl-3β-androstanediol is a positional isomer of 17α-ethynyl-3α-androstanediol, and is a metabolite of this compound in ... 17α-Ethynyl-3β-androstanediol (developmental code HE-3539; also known as 17α-ethynyl-5α-androstane-3β,17β-diol) is a synthetic ...
5α-androstane-3,17-dione) and estrone (estra-1,3,5(10)-triene-3-ol-17-one or 19-norandrost-1,3,5(10)-triene-3-ol-17-one). ... is a naturally occurring androstane steroid and a 17-ketosteroid. It is closely related structurally to androstenediol (A5; ... 138 (3): 863-70. doi:10.1210/endo.138.3.4979. PMID 9048584. Gray PB, McHale TS, Carré JM (May 2017). "A review of human male ... Thus, 17,20-lyase is required for the synthesis of androstenedione, whether immediately or one step removed. Androstenedione is ...
17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as ... Wilson JD, Auchus RJ, Leihy MW, Guryev OL, Estabrook RW, Osborn SM, Shaw G, Renfree MB (February 2003). "5alpha-androstane- ... androsterone and 5α-androstane-3α,17β-diol. 5α-Pregnan-17α-ol-3,20-dione is produced by 5α-reduction of 17-OHP. The reaction is ... 5α-Pregnan-17α-ol-3,20-dione, also known as 17α-hydroxy-dihydroprogesterone (17‐OH-DHP) is an endogenous steroid. 5α-Pregnan-17 ...
5β-androstane) steroid and an endogenous metabolite of testosterone. It is formed from 5β-dihydrotestosterone (after 5β- ... 3α-Etiocholanediol, or simply etiocholanediol, also known as 3α,5β-androstanediol or as etiocholane-3α,17β-diol, is a naturally ... 3β-Etiocholanediol 3α-Androstanediol 3β-Androstanediol [1] Metabocard for Etiocholanediol (HMDB00551) - Human Metabolome ...
... androstane-3,17-diol MeSH D06.472.334.851.968.750 - androstenediol MeSH D06.472.334.851.968.875 - androstenedione MeSH D06.472. ... 17-ketosteroids MeSH D06.472.040.502.112 - androstenedione MeSH D06.472.040.502.195 - androsterone MeSH D06.472.040.502.497 - ... 17-hydroxycorticosteroids MeSH D06.472.040.585.478.195 - cortisone MeSH D06.472.040.585.478.225 - cortodoxone MeSH D06.472. ... 17-alpha-hydroxypregnenolone MeSH D06.472.317.152 - cholecystokinin MeSH D06.472.317.152.700 - sincalide MeSH D06.472.317.350 ...
This is a list of androstanes, or androstane derivatives. Androstanol 3α,5α-Androstanol (5α-androstan-3α-ol) - an endogenous ... 5α-androstane-3α,17β-diol) - an endogenous androgen, estrogen, and neurosteroid 3β-Androstanediol (5α-androstane-3β,17β-diol ... 5α-androstane-3,17-dione) 5β-Androstanedione (5β-androstane-3,17-dione) Androstanolone Dihydrotestosterone (5α-androstan-17β-ol ... an endogenous pheromone Many synthetic androgens and anabolic steroids are androstane derivatives. Some progestins, such
It is an androstane steroid and analogue of 5-androstenediol (androst-5-ene-3β,17β-diol) and 16α-hydroxy-DHEA (androst-5-ene-3β ... 16α-diol, is a drug described as a "steroid tranquilizer" which was briefly investigated as a treatment for alcoholism in the ... 16α-diol-17-one), but showed no androgenic or myotrophic activity in animal bioassays. The drug was reported in 1956 and ... ISBN 978-3-527-30247-5. LEMERE F (1957). "New steroid hormone tranquilizing agent (cetadiol)". Am J Psychiatry. 113 (10): 930. ...
... is a synthetic androstane steroid and a 17α-alkylated derivative of testosterone (androst-4-en-17β-ol-3-one). It is ... 154 (3): 502-521. doi:10.1038/bjp.2008.165. PMC 2439524. PMID 18500378. Attardi BJ, Pham TC, Radler LC, Burgenson J, Hild SA, ... 110 (3-5): 214-22. doi:10.1016/j.jsbmb.2007.11.009. PMC 2575079. PMID 18555683. Norman T. Adler; Donald Pfaff; Robert W. Goy (6 ... doi:10.1007/978-3-642-66353-6_16. ISBN 978-3-642-66355-0. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: ...
... is a naturally occurring androstane steroid and a 17-ketosteroid. It is closely related structurally to androstenediol (androst ... DHEA sulfate, the 3β-sulfate ester of DHEA, was isolated from urine in 1944, and was found by Baulieu to be the most abundant ... ISBN 978-3-527-30247-5. 3β-Hydroxyandrost-5-en-17-one hydrogen sulfate = (3β)-3-(Sulfooxy)androst-5-en-17-one. R: Sodium salt ( ... 137-. ISBN 978-3-540-79088-4. Parr MK, Opfermann G, Geyer H, Westphal F, Sönnichsen FD, Zapp J, Kwiatkowska D, Schänzer W (2011 ...
5β-androstane) steroid and an endogenous metabolite of testosterone. It is formed from 5β-dihydrotestosterone (after 5β- ... 3β-Etiocholanediol, or epietiocholanediol, also known as 3β,5β-androstanediol or as etiocholane-3β,17β-diol, is a naturally ... 3α-Etiocholanediol 3α-Androstanediol 3β-Androstanediol Miller AM, Dorfman RI (March 1948). "Metabolism of the steroid hormones ... 42 (3): 174. doi:10.1210/endo-42-3-174. PMID 18914211. v t e v t e. ...
... is a synthetic androstane steroid and a 17α-alkylated derivative of 5-androstenediol (androst-5-ene-3β,17β-diol). A number of ... β-diol". The Journal of Organic Chemistry. 22 (4): 472-473. doi:10.1021/jo01355a626. ISSN 0022-3263. Schänzer W (1996). " ... 21-. ISBN 978-3-7091-5694-0. Bernstein, Seymour; Stolar, Stephen; Heller, Milton (1957). "Notes - Synthesis of 17α-Methyl-4- ... It is an orally active 17α-alkylated AAS and a derivative of the endogenous androgen prohormone androstenediol. Methandriol has ...
5α-androstane-3α,17β-diol) - an endogenous neurosteroid, weak androgen and estrogen, and intermediate to androsterone 3β- ... 5α-androstane-3β,17β-diol) - an endogenous estrogen and intermediate to epiandrosterone 3α-Etiocholanediol (5β-androstane-3α,17 ... β-diol; etiocholane-3α,17β-diol) - an endogenous intermediate to etiocholanolone 3β-Etiocholanediol (5β-androstane-3β,17β-diol ... etiocholane-3β,17β-diol) - an endogenous intermediate to epietiocholanolone Etiocholanediol
5α-androstane-3α,17β-diol, dihydrotestosterone and Δ5-androstene-3β,17β-diol is described (for review see Mindnich et al. ( ... 2004b). Additionally, human 17β-HSD type 2 has high 20α-HSD activity with progestins (Puranen et al., 1999). Wang CT, Li CF, Wu ... 17β-HSD2, an enzyme with broad tissue distribution (Casey et al., 1994), plays its major role in the inactivation of potent ... 25 (3): 724-6. doi:10.1016/0888-7543(95)80017-G. PMID 7759109. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia ...
16α-diol - undefined mechanism of action; developed as a "tranquilizer" and for the treatment of alcoholism in the 1950s List ... 5β-androstane-3α,17β-diol - GABAA receptor positive allosteric modulator 3α-Androstenol: 5α-androst-16-en-3α-ol - GABAA ... 21-diol - TrkA and p75NTR agonist Testosterone: androst-4-en-17β-ol-3-one - TrkA and p75NTR antagonist Dexamethasone: 9α-fluoro ... 24S-diol - NMDA receptor positive allosteric modulator 3β-Dihydroprogesterone (3β-DHP): pregn-4-en-3β-ol-20-one - GABAA ...
... androstane-3,17-diol MeSH D04.808.054.040.129 - androsterone MeSH D04.808.054.040.248 - dihydrotestosterone MeSH D04.808. ... vitamin k 3 MeSH D04.615.638.845 - 1-naphthylamine MeSH D04.615.638.845.800 - sertraline MeSH D04.615.638.850 - 2-naphthylamine ... 25-dihydroxyvitamin d 3 MeSH D04.808.247.808.197 - cholesterol MeSH D04.808.247.808.197.070 - azacosterol MeSH D04.808.247.808. ... 25-dihydroxyvitamin d 3 MeSH D04.808.247.222.222 - cholestadienes MeSH D04.808.247.222.222.347 - cholestadienols MeSH D04.808. ...
5α-androstane-3α,17β-diol) to dihydrotestosterone (DHT, 5α-androstan-17β-ol-3-one) and vice versa. This gene encodes a member ... 3α-Hydroxysteroid dehydrogenase (3α-HSD or aldo-keto reductase family 1 member C4) is an enzyme that in humans is encoded by ... 11 (3): 261-72. doi:10.1038/sj.mp.4001782. PMID 16344854. Human AKR1C4 genome location and AKR1C4 gene details page in the UCSC ... Binstock JM, Iyer RB, Hamby CV, Fried VA, Schwartz IS, Weinstein BI, Southren AL (September 1992). "Human hepatic 3 alpha- ...
... also known as 5α-androstane-3α,17β-diol, is a naturally occurring androstane steroid and a structural analogue of DHT (5α- ... 138 (3): 863-70. doi:10.1210/endo.138.3.4979. PMID 9048584. Hong H, Branham WS, Ng HW, Moland CL, Dial SL, Fang H, Perkins R, ... 3α-Androstanediol also known as 5α-androstane-3α,17β-diol and sometimes shortened in the literature to 3α-diol, is an ... As androgens such as testosterone and DHT are known to have many of the same effects as 3α-diol and are converted into it in ...
Mahendroo M, Wilson JD, Richardson JA, Auchus RJ (July 2004). "Steroid 5alpha-reductase 1 promotes 5alpha-androstane-3alpha, ... 17beta-diol synthesis in immature mouse testes by two pathways". Molecular and Cellular Endocrinology. 222 (1-2): 113-20. doi: ... 20-diol). In addition, allopregnanolone is one of four isomers of pregnanolone (3,5-tetrahydroprogesterone), with the other ... 199 (3): 251-65. doi:10.1016/j.taap.2003.12.027. PMID 15364541. Hu AQ, Wang ZM, Lan DM, Fu YM, Zhu YH, Dong Y, et al. (July ...
... , or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous ... C-19: Androstane). 1. Dehydroepiandrosterone → Androstenedione → 5α-Androstanedione1 → Androsterone1. 2. Androstenediol → ... 5α-androstane-3β,17β-diol).[5] Research[edit]. Radiation countermeasure[edit]. Androstenediol has been investigated for use as ... A5; Δ5-Diol; Androstenediol; Androst-5-ene-3β,17β-diol; Hermaphrodiol; HE2100. ...
17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as ... Wilson JD, Auchus RJ, Leihy MW, Guryev OL, Estabrook RW, Osborn SM, Shaw G, Renfree MB (February 2003). "5alpha-androstane- ... 5α-androstane-3α,17β-diol (androstanediol) → DHT. This pathway is not always considered in the clinical evaluation of patients ... is a naturally occurring androstane steroid with a ketone group at the C3 position and a hydroxyl group at the C17β position. ...
Oliveira AG, Coelho PH, Guedes FD, Mahecha GA, Hess RA, Oliveira CA (December 2007). "5alpha-Androstane-3beta,17beta-diol ( ... 1S,2S,5S,7S,10R,11S,14S,15S)-2,15-Dimethyltetracyclo-[8.7.0.02,7.011,15]heptadecane-5,14-diol ... Huang, Q; Zhu, H; Fischer, D; Zhou, J (2008). "An estrogenic effect of 5α-androstane-3β, 17β-diol on the behavioral response to ... "A Role for the Androgen Metabolite, 5alpha Androstane 3beta, 17beta Diol (3?-Diol) in the Regulation of the Hypothalamo- ...
... (4-OHT), also known as 4,17β-dihydroxyandrost-4-en-3-one, is a synthetic anabolic-androgenic steroid (AAS ... InChI=1S/C19H28O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,16,21-22H,3-10H2,1-2H3/t11-,12-, ... O=C4C(\O)=C2/[[email protected]]([[email protected]]1CC[[email protected]@]3([[email protected]@H](O)CC[[email protected]]3[[email protected]@H]1CC2)C)(C)CC4 ... 4,17β-Dihydroxyandrost-4-en-3-one; Androst-4-ene-4,17β-diol-3-one; Desmethylenestebol. ...
978-3-88763-075-1. .. *^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and ... 8R,9S,10R,13S,14S,17S)-4-hydroxy-13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]- ... 17α-Vinyltestosterone derivatives: Norvinisterone (vinylnortestosterone). *17α-Vinyl-19-nortestosterone derivatives: ... C[[email protected]]12CC[[email protected]]3[[email protected]]([[email protected]@H]1CC[[email protected]@H]2OC(=O)CCC4CCCC4)CCC5=C(C(=O)CC[[email protected]]35)O ...
激动剂: 5α-Androstane-3β,17β-diol. *16α-Hydroxyestrone ... 维基媒体基金会是在美国佛罗里达州登记的501(c)(3)免税、非营利、慈善机
Huang Q, Zhu H, Fischer DF, Zhou JN (June 2008). "An estrogenic effect of 5alpha-androstane-3beta, 17beta-diol on the ... ISBN 978-3-642-45745-6. At daily doses of 10, 30 and 50 mg decreases of this range were noted in 33%, 53% and 83% of treated ... ISBN 978-3-319-31341-2. Archived from the original on 8 September 2017. Masiello D, Cheng S, Bubley GJ, Lu ML, Balk SP (July ... 106-. ISBN 978-3-319-04385-2. The standard castrate level is 3.0.CO;2-X. PMID 10221266. Chung LW, Isaacs WB, Simons JW (10 ...
"Relative binding affinity of androstane and C-19-nor-androstane-steroids for the estradiol-receptor in human myometrial and ... 24 (3): 188-93. doi:10.1093/jat/24.3.188. PMID 10774538. Detlef Thieme; Peter Hemmersbach (18 December 2009). Doping in Sports ... 137-. ISBN 978-3-540-79088-4. Jehuda Yinon (29 December 2003). Advances in Forensic Applications of Mass Spectrometry. CRC ... Uralets VP, Gillette PA (April 2000). "Over-the-counter Δ5 anabolic steroids 5-androsen-3,17-dione; 5-androsten-3β, 17β-diol; ...
Androstane analogues of EE with significant although weak estrogenic activity include ethinylandrostenediol (17α-ethynyl-5- ... ISBN 978-3-662-07635-4. Gerstman BB, Gross TP, Kennedy DL, Bennett RC, Tomita DK, Stadel BV (January 1991). "Trends in the ... ISBN 978-3-642-60107-1. The binding affinity of EE2 for the estrogen receptor is similar to that of estradiol. [...] During ... On the other hand, due to the loss of inactivation of EE by 17β-HSD in the endometrium (uterus), EE is relatively more active ...
17beta-diol, its delta 5-analog and derivatives". Proc. Soc. Exp. Biol. Med. 92 (2): 404-8. doi:10.3181/00379727-92-22493. PMID ... 11 (3): 537-45. doi:10.1002/1097-0142(195805/06)11:3. 3.0.co;2-w. PMID 13523561. v t e v t e v t e. ... doi:10.1007/978-3-642-99941-3_6. ISBN 978-3-642-99942-0. Stavely, H. E. (1939). "Preparation of a Pregnane Compound from ... 62 (3): 489-491. doi:10.1021/ja01860a007. ISSN 0002-7863. C. W. Emmens (22 October 2013). Hormone Assay. Elsevier Science. pp. ...
Huang Q, Zhu H, Fischer DF, Zhou JN (June 2008). "An estrogenic effect of 5alpha-androstane-3beta, 17beta-diol on the ... 394-. ISBN 978-3-642-42014-6. de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, ... 575-. ISBN 978-3-642-30725-6. Archived from the original on 24 June 2016. Bohl CE, Gao W, Miller DD, Bell CE, Dalton JT (April ... ISBN 978-3-319-31341-2. Archived from the original on 8 September 2017. Masiello D, Cheng S, Bubley GJ, Lu ML, Balk SP (July ...
"5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane- ... 5α-androstane-3α,17β-diol → DHT. 5α-Pregnane-3α,17α-diol-20-one is produced from 5α-pregnan-17α-ol-3,20-dione in a reaction ... 3alpha,17alpha-diol-20-one as a key intermediate". Endocrinology. 144 (2): 575-80. doi:10.1210/en.2002-220721. PMID 12538619. ... The product of 17-hydroxyprogesterone reduction, 5α-pregnan-17α-ol-3,20-dione, was metabolized by a reductive 3α-HSD to a new ...
... diol, TMS; 5B-Androstane-3A,17B-diol, TMS; 5.beta.-Androstane-3.alpha.,17.beta.-diol, bis(trimethylsilyl) ether; Androstanediol ... Androstane-3,17-diol, (3«alpha»,5«beta»,17«beta»)-, 2TMS derivative. *Formula: C25H48O2Si2 ... 5A-Androstan-3A,17B-diol), TMS; 5B-Androstan-3A,17B-diol, bis-TMS ... diol, bis-TMS; 5«beta»-Androstanediol-3«alpha»,17«beta», bis-TMS; 5beta-Androstan-3alpha,17beta-diol, bis-TMS; 5-«beta»- ...
Androstane-3-«alpha»,17-«alpha»-diol. *Formula: C21H36O2 ...
We use serum 5α-androstane-3α,17β-diol glucuronide (3α-dG), a distal metabolite of DHT, as a surrogate measure of ... Associations of Serum Sex Steroid Hormone and 5α-Androstane-3α,17β-Diol Glucuronide Concentrations with Prostate Cancer Risk ... Serum concentrations of 5α-androstane-3α,17β-diol glucuronide, sex steroid hormones, and sex hormone binding globulin, before ... Spearman correlations among changes in 5α-androstane-3α,17β-diol glucuronide, sex steroid hormones, and sex hormone binding ...
The androgen metabolite, 5α-androstane-3β,17β-diol, decreases cytokine-induced cyclooxygenase-2, vascular cell adhesion ... The principal metabolite of DHT, 5α-androstane-3β,17β-diol (3β-diol), activates estrogen receptor (ER)β and similarly decreases ... 23117931] The androgen metabolite, 5α-androstane-3β,17β-diol, decreases cytokine-induced cyclooxygenase-2, vascular cell ... The androgen metabolite, 5α-androstane-3β,17β-diol, decreases cytokine-induced cyclooxygenase-2, vascular cell adhesion ...
Fingerprint Dive into the research topics of The androgen derivative 5α-androstane-3β,17β-diol inhibits prostate cancer cell ... The androgen derivative 5α-androstane-3β,17β-diol inhibits prostate cancer cell migration through activation of the estrogen ...
The 5 alpha-Androstane-3 alpha 17 beta-diol Glucuronide 3 alpha-Diol G ELISA is for the direct quantitative determination of 3α ... 5α-Diol G or simply, α-Diol G. It is produced mainly as a metabolite of testosterone and dihydrotestosterone (DHT). It is ... Home / All Products / Assay Kits / Endocrine Assay Kits / 5 alpha-Androstane-3 alpha 17 beta-diol Glucuronide 3 alpha-Diol G ... 5 alpha-Androstane-3 alpha 17 beta-diol Glucuronide 3 alpha-Diol G ELISA. 5 alpha-Androstane-3 alpha 17 beta-diol Glucuronide 3 ...
It is known that DHT can be metabolized to 5α-androstane-3β,17β-diol (3β-diol), a hormone that binds to ERβ but not to AR. The ... Oliveira, A. G., Coelho, P. H., Guedes, F. D., Mahecha, G. A. B., Hess, R. A., & Oliveira, C. A. (2007). 5α-Androstane-3β,17β- ... It is known that DHT can be metabolized to 5α-androstane-3β,17β-diol (3β-diol), a hormone that binds to ERβ but not to AR. The ... It is known that DHT can be metabolized to 5α-androstane-3β,17β-diol (3β-diol), a hormone that binds to ERβ but not to
Associations of Serum Sex Steroid Hormone and 5α-Androstane-3α,17β-Diol Glucuronide Concentrations with Prostate Cancer Risk ... which is reflected in serum as reduced 5α-androstane-3α,17β-diol glucuronide (3α-dG). It also modestly increases serum ... Neither the pre- nor posttreatment concentrations of 3α-dG, nor its change, were associated with risk. Pretreatment, high ... concentrations of 3α-dG were not associated with total or Gleason grades 2 to 6, 7 to 10, or 8 to 10 cancer. High serum ...
Androstane-3,17-diol / analogs & derivatives * Androstane-3,17-diol / analysis * Anthropometry ...
Androstane-3,17-diol / administration & dosage * Androstane-3,17-diol / pharmacology* * Androstanes / pharmacology* ...
In den auswertbaren Wasserproben konnten die Substanzen Androsteron, 5?-Androstane-3?,17?-diol, 5?-Dihydrotestosteron und ?- ... 3 Stars - It was OK 4 Stars - I liked it 5 Stars - I loved it ...
androstane 3α, 17β-diol glucuronide * androstane 3β, 17β-diol glucuronide ... 3. All of the participants in the NAMS statement, but not The Endocrine Society group, have a specialty interest in female ... 17. Mantzoros CS, Georgiadis EI, Young R, Evagelopoulou C, Khoury S, Katsilambros N, Sowers JR Relative androgenicity, blood ... Fertil Steril 88:1-17. 24. Wierman ME, Basson R, Davis SR, Khosla S, Miller KK, Rosner W, Santoro N Androgen therapy in women: ...
... androstane-3,17-diol. ... 3 of single sex. Details on study design:. TEST SITE. - Area of ... 3 Animals of one sex. Details on study design:. SCORING SYSTEM: See Tables No. 1 - 5 below. TOOL USED TO ASSESS SCORE: ... 3. Reversibility:. fully reversible within: 72 hours. Irritation parameter:. chemosis score. Basis:. mean. Time point:. other: ...
... diol (Aenediol) or 5?-androstane-3?, 17?-diol (Aanediol), are known to have estrogenic functions, although they have been ... 5?-Androstane-3?, 17?-diol was undetectable in most samples. Androstene-3?, 17?-diol proliferated estrogen receptor-apositive ... diol.. Naoko Honma, Shigehira Saji, Makiko Hirose, Shin-Ichiro Horiguchi, Katsumasa Kuroi, Shin-Ichi Hayashi, Toshiaki Utsumi, ... Both treatments were well-tolerated with no severe adverse events, although the treatment of 3 of 43 women administered TOR120 ...
Expected to use NAD(+) as preferred electron donor for the 3-beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3- ... Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the ... steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the ... 5alpha-androstane-3beta,17beta-diol dehydrogenase activity Source: UniProtKB-EC. *cholesterol dehydrogenase activity Source: ...
Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also ... 5α-androstane-3α,17β-diol*Search proteins in UniProtKB for this molecule. ... 5α-androstane-3α,17β-diol*Search proteins in UniProtKB for this molecule. ... androstan-3-alpha,17-beta-diol dehydrogenase activity Source: UniProtKB. *androsterone dehydrogenase activity Source: UniProtKB ...
5α-androstane-3α,17β-diol glucuronide; and estradiol), or sex hormone-binding globulin. These variables therefore were not ... Table 3 ORsa for prostate cancer in relation to AIB/SRC-3 CAG/CAA and AR CAG or GGN repeat lengths in Chinese men ... AIB1/SRC-3 Gene.. The polyglutamine region of the AIB1/SRC-3 protein is encoded by two glutamine codons in the AIB1/SRC-3 gene ... Polymorphic CAG/CAA Repeat Length in the AIB1/SRC-3 Gene and Prostate Cancer Risk. A Population-based Case-Control Study. Ann W ...
5α-Androstane-3β,17β-diol. 17 5β-Androstane-3α,17β-diol. 5 ... Chr 17: 7.61 - 7.63 Mb. Chr 11: 69.61 - 69.62 Mb. PubMed search ... 25 (3): 374-88. doi:10.1210/er.2003-0016. PMID 15180949.. *^ a b c d e f g h i Winters SJ, Huhtaniemi IT (25 April 2017). Male ... 44-. ISBN 978-1-4511-4847-3.. *^ a b c Hammond GL, Bocchinfuso WP (1996). "Sex hormone-binding globulin: gene organization and ... ISBN 978-3-319-53298-1.. *^ Becker K, Bilezikian JP, Bremner WJ, Hung W, Kahn CR (24 April 2001). Principles and Practice of ...
Phase determination by least-squares analysis of structure invariants: discussion of this method as applied to two androstane ... l7β-diol. ... Dioxonium-di-hydrogen-hypophosphat, (H3O+)2[H2P2O62−]. ... I. Structure cristalline du diperoxodioxalatoniobate dammonium à une molécule deau, (NH4)3Nb(O2)2(C2O4)2.H2O. ... Structure cristalline de loxotrioxalatoniobate dammonium à une molécule deau, (NH4)3NbO(C2O4)3.H2O. ...
2009) The androgen metabolite 5alpha-androstane-3beta,17beta-diol (3betaAdiol) induces breast cancer growth via estrogen ... 5α-androstane-3β, 17β-diol. AR. androgen receptor. DHT. dihydrotestosterone. DTT. dithiothreitol. E2. estradiol. ERα. estrogen ... Likewise, NAT1 transcript levels were not increased by dihydrotestosterone (DHT) or 5α-androstane-3β, (3β-adiol) 17β-diol. ... In other experiments, cells were treated with dihydrotestosterone (DHT), 5α-androstane-3β , 17β-diol (3β-adiol), both from ...
The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17- ... beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).. Pfam Domain Function. *UDPGT (PF00201) ...
Androstane-3α,17β-diol 3-D-glucuronide. Synonyms. -. Exact Mass. 468.2723 (neutral) Calculate m/z: (Select m/z). [M+H]+. [M+H- ... C1[[email protected]@H](O[[email protected]]2[[email protected]](C(O)[[email protected]](O)C(C(=O)O)O2)O)C[[email protected]]2([H])CC[[email protected]@]3([H])[[email protected]]4([H])CC[[email protected]](O)[[email protected]@]4(C)CC[[email protected]]3([H])[[email protected]@]2(C)C1 ... 3. van der Waals. Molecular Volume. 446.94. Topological Polar. Surface Area. 138.75. Hydrogen. Bond Donors. 5. Hydrogen. Bond ... 3-4-14-15-5-6-17(26)25(15,2)10-8-16(14)24/h12-21,23,26-29H,3-11H2,1-2H3,(H,30,31)/t12-,13+,14-,15-,16-,17-,18?,19-,20-,21?,23+, ...
Androst-5-ene-3b,17b-diol-17a-H3 to testosterone-17a-H3 and 5a- and 5b-androstane-3a,17b-diol-17a-H3 in vivo. Steroids (1963), ... 1S,2S,5R,7R,10R,11S,14S,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane-5,14-diol. ... 1S,2S,5R,7R,10R,11S,14S,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane-5,14-diol. ... InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12-,13-,14+, ...
"Inhibition of androstenediol-dependent LNCaP tumour growth by 17alpha-ethynyl-5alpha-androstane-3alpha, 17beta-diol (HE3235)". ... is a synthetic androstane steroid and a 17α-substituted derivative of 3α-androstanediol which was never marketed. It was under ... 17beta-diol, its delta 5-analog and derivatives". Proc. Soc. Exp. Biol. Med. 92 (2): 404-8. doi:10.3181/00379727-92-22493. PMID ... 17α-Ethynyl-3α-androstanediol itself shows very low affinity for steroid receptors, including the AR, ERα, ERβ, PR, and GR, and ...
1lhn: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17ALPHA-DIOL ... 1lho: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17BETA-DIOL ... 25 (3): 374-88. doi:10.1210/er.2003-0016. PMID 15180949.. *↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Winters SJ, Huhtaniemi IT (25 ... ISBN 978-3-319-53298-1.. *↑ Becker K, Bilezikian JP, Bremner WJ, Hung W, Kahn CR (24 April 2001). Principles and Practice of ...
5 a-Androstane-3 a, 17 b-diol. *5 alpha-Androstane-3 alpha, 17 beta-diol ... The GeneCards human gene database index: 2 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ... 3. HDAC1 CTCF RB1 RAD21 YY1 TEAD3 CC2D1A GATA3 GATA2 ZNF157 GPR182 ENSG00000258199 MYO1A RDH16 STAT6 BAZ2A HSD17B6 ... 3alpha,5alpha)-3-hydroxy-Androstan-17-one. *(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16 ...
... androstane. Regulatory process names 1 CAS names 1 IUPAC names 3 Trade names 1 Other names 2 Other identifiers 1 ... Androstane-3,17-diol, 2-(4-morpholinyl)-16-(1-pyrrolidinyl)-, 17-acetate, (2.beta.,3.alpha.,5.alpha.,16.beta.,17.beta.)- ... Androstane-3,17-diol, 2-(4-morpholinyl)-16-(1-pyrrolidinyl)-, 17-acetate, (2β,3α,5α,16β,17β)- ... androstane-3,17-diol, 2-(4-morpholinyl)-16-(1-pyrrolidinyl)-, 17-acetate, (2beta,3alpha,5alpha,16beta,17beta)- ...
This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ... The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17- ... beta-diol (3-alpha-diol) > testosterone > androsterone (ADT). Gene Name:. UGT2B17. Uniprot ID:. O75795 Molecular weight:. ... H][[email protected]]12CC3(C(O[[email protected]@H]4O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]]4O)C(O)=O)O1)C(CC[[email protected]@H]3C(=O)CO)C1CCC3=CC(=O)CC[[email protected]]3(C)C21 ...
Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous ... 5α-androstane-3β,17β-diol). Derivatives and analogues of androstenediol, such as the 17α-substituted methandriol (17α- ... is a naturally occurring androstane steroid. It is closely related structurally to androstenedione (A4; androst-4-ene-3,17- ... 43-. ISBN 978-3-540-33120-9. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and ...
This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ... The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17- ... beta-diol (3-alpha-diol) > testosterone > androsterone (ADT). Gene Name:. UGT2B17. Uniprot ID:. O75795 Molecular weight:. ... 2005 Jun;27(3):375-7. [PubMed:15905810 ] *Safford KM, Hicok KC, Safford SD, Halvorsen YD, Wilkison WO, Gimble JM, Rice HE: ...
  • 5α-Androstane-3α, 17β-diol glucuronide is a C19 steroid and is either abbreviated as 3α-Diol G, 5α-Diol G or simply, α-Diol G. It is produced mainly as a metabolite of testosterone and dihydrotestosterone (DHT). (eaglebio.com)
  • Among the steroids known to be precursors for 3α-Diol G are dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), dihydrotestosterone (DHT), androstenedione and testosterone. (eaglebio.com)
  • Likewise, NAT1 transcript levels were not increased by dihydrotestosterone (DHT) or 5 α -androstane-3 β , (3 β -adiol) 17 β -diol. (aspetjournals.org)
  • It is a 5α-reduced and 17β-hydroxylated metabolite of dehydroepiandrosterone (DHEA) as well as a 3β-hydroxylated metabolite of dihydrotestosterone (DHT). (wikipedia.org)
  • [13] [14] Androgens, including testosterone and dihydrotestosterone (DHT), are known to downregulate the hypothalamic-pituitary-adrenal axis , and this has been found to be due in part or full to their conversion into 3β-diol rather than to activation of the AR. (wikipedia.org)
  • However, the ratio of testosterone (T) to either 5α-dihydrotestosterone (DHT) or 5α-androstane-3α, 17β-diol (diol) can provide a better discriminant. (springer.com)
  • Ghanadian R, Puah CM (1981) Relationships between oestradiol-17β, testosterone, dihydrotestosterone and 5α-androstane-3α,17β-diol in human benign hypertrophy and carcinoma of the prostate. (springer.com)
  • However, some recent studies suggest that ERβ may play an antiproliferative role in the regulation of prostatic epithelial differentiation, probably through activation by 5α-androstane-3β,17β-diol, a newly identified ERβ ligand derived metabolically from dihydrotestosterone ( 8 - 10 ). (aacrjournals.org)
  • We used GC-MS and LC-MS to measure serum sex steroid concentrations, including testosterone and dihydrotestosterone, and 3-diol-3G and 3-diol-17G in 1182 Chinese elderly men age 65 and older. (scialert.net)
  • Testosterone (T) is aromatized to estrogen, and reduced to dihydrotestosterone (DHT), which is converted to 5α-androstane, 3α, 17α-diol (3α-diol). (frontiersin.org)
  • LNCaP, a human prostate cancer cell line, metabolizes testosterone into a variety of 5 alpha-reduced C19 steroids, such as dihydrotestosterone (DHT), androstane-3 alpha, 17 beta-diol (3 beta, 17 beta-DIOL), and androsterone (ADT). (nih.gov)
  • UDP glucuronosyltransferase 2B17 is present in the prostate, where it catalyzes the addition of glucuronic acid to testosterone and dihydrotestosterone and their metabolites androsterone and androstane-3α,17β-diol. (aspetjournals.org)
  • Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). (nih.gov)
  • The yields of bound zinc are decreased by androgenic steroids (testosterone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol) which increase in turn the levels of free zinc, the uptake and the reduction of testosterone and citrate accumulation. (anagen.net)
  • AKR1C3 metabolizes various androgen metabolites including 5a-dihydrotestosterone to 5a-androstane-3a,17b-diol, Delta 4 -androstene-3,17-dione to testosterone, androstanedione to 5a-dihydrotestosterone, androsterone to 5a-androstane-3a,17b-diol. (atlasgeneticsoncology.org)
  • Examples are 17-OH-Progesterone (17-OH-P), 5α-Dihydrotestosterone (DHT), Estrone (E1). (ibl-international.com)
  • Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. (gentaur.com)
  • Initially described as a route where 5α-reduction of 17α-hydroxyprogesterone ultimately leads to 5α-dihydrotestosterone, several other routes have been discovered towards 11-oxyandrogens which are potent agonists of the androgen receptors. (wikiversity.org)
  • Androgen backdoor pathway from 17α-hydroxyprogesterone to 5α-dihydrotestosterone. (wikiversity.org)
  • In 2003, a metabolic route from 17α-hydroxyprogesterone to 5α-dihydrotestosterone without testosterone intermediary was described [1] , called in 2004 the "backdoor pathway" [2] . (wikiversity.org)
  • Therefore, the pathway can be outlined as 17α-hydroxyprogesterone (17-OHP) → 5α-pregnan-17α-ol-3,20-dione (17‐OH-DHP) → 5α-pregnane-3α,17α-diol-20-one (5α-pdiol) → 5α-androstan-3α-ol-17-one (androsterone) → 5α-androstane-3α,17β-diol (3α-diol) → 5α-dihydrotestosterone (DHT (wikiversity.org)
  • The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. (mybiosource.com)
  • It is closely related to androstenedione (androst-4-ene-3,17-dione). (wikipedia.org)
  • Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA) and of estrone. (wikipedia.org)
  • Irreversible androgenic programming at birth of microsomal and soluble rat liver enzymes active on androst-4-ene-3,17-dione and 5a-androstane-3α,17β-diol.J.Biol.Chem 249:711-718. (springer.com)
  • The 5 alpha-Androstane-3 alpha 17 beta-diol Glucuronide 3 alpha-Diol G ELISA is for the direct quantitative determination of 3α-Diol G by an enzyme immunoassay in human serum. (eaglebio.com)
  • Results of recent studies have demonstrated that genetic variants of the enzyme steroid 5 reductase type II (SRD5A2) are associated with serum concentrations of major androgen metabolites such as conjugates of androstane-3,17β-diol-glucuronide (3-diol-G). However, this association was not consistently found among different ethnic groups. (scialert.net)
  • Thus, we aimed to determine whether the association with SRD5A2 genetic variations exists in a cohort of healthy Chinese elderly men, by examining 2 metabolite conjugates: androstane-3,l7β-diol-3-glucuronide (3-diol-3G) and androstane-3,17β-diol-17-glucuronide (3-diol-17G). (scialert.net)
  • Further analysis by LCMS also indicated that the glucuronide group in 3 alpha-DIOL-G was at position 17-carbon, 3 alpha-DIOL-G (86 +/- 3%) was the prominent metabolite formed from 3 alpha-DIOL, a minor product was detected at 7 +/- 1% and identified by mass spectrometry to correspond to a trihydroxylated C19 steroid. (nih.gov)
  • Consonant with its capacity to be stimulated by FOXA1, the UGT2B17 −155A allele, compared with the −155G allele, is associated with higher levels of circulating androstane-3α,17β-diol glucuronide. (aspetjournals.org)
  • As an example, we report here that hydroxyestradiol-17β-glucuronide can be directly formed through oxidation of estradiol-17β-glucuronide on the aromatic C2 position. (aspetjournals.org)
  • In the present study, we demonstrate the formation of 2-hydroxy-estradiol-17β-glucuronide by direct CYP 2C8 oxidation of estradiol-17β-glucuronide. (aspetjournals.org)
  • 6β-Hydroxyl-estradiol was obtained from Steraloids (Newport, RI), and tritiated estradiol-17β-glucuronide [estradiol-6,7- 3 H (N)] was obtained from PerkinElmer Life and Analytical Sciences (Paris, France). (aspetjournals.org)
  • After 16 weeks of treatment, levels of circulating androgens were found to have decreased significantly in the EA group (testosterone -25%, androsterone glucuronide -30%, and androstane-3? (ogka.at)
  • The concentration of 3β-diol in prostate is much higher than that of estradiol. (illinois.edu)
  • To test this hypothesis, adult male rats were submitted to castration followed by estradiol, DHT or 3β-diol replacement. (illinois.edu)
  • It has approximately 6% and 17% of the affinity of estradiol at the ERα and ERβ, respectively. (wikipedia.org)
  • [4] [5] It has approximately 3% and 7% of the affinity of estradiol at the ERα and ERβ , respectively. (wikipedia.org)
  • Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). (abcam.com)
  • [3] Although androstenediol has far lower affinity for the ERs compared to the major estrogen estradiol , it circulates at approximately 100-fold higher concentrations, and so is thought may play a significant role as an estrogen in the body. (wikipedia.org)
  • They repeated what the other researchers had reported, that the "mechanism of action" is stimulation of ERβ by 3β-Adiol, and added that estradiol (a major estrogen) could not stimulate ERβ to do these same things, only 3β-Adiol could do this! (anh-usa.org)
  • Based on this approach, we propose an HRPT for ERα agonism of 1E-04 relative to the potency of the endogenous estrogenic hormone 17β-estradiol or the pharmaceutical estrogen, 17α-ethinylestradiol. (springer.com)
  • It produces 5α-dihydroethisterone (5α-dihydro-17α-ethynyltestosterone), a ligand of several steroid hormone receptors, and 17α-ethynyl-3β-androstanediol, an estrogen, as active metabolites. (wikipedia.org)
  • These metabolites may contribute importantly to the biological activity of 17α-ethynyl-3α-androstanediol, with 17α-ethynyl-3α-androstanediol potentially serving as a prodrug. (wikipedia.org)
  • The main parameters of the urinary steroid profile are the concentrations and ratios of the testosterone metabolites androsterone (A), etiocholanolone (Etio), 5α-androstane-3α,17β-diol (5α-diol) and 5β-androstane-3α,17β-diol (5β-diol), in addition to epitestosterone (E) (which originates from the biosynthesis of testosterone) and testosterone (T). The ratio of the most importance is the T/E ratio. (stitcher.com)
  • Moreover, while about 3 out of 4 ART users had measured testosterone levels [ 6 ], most of them did not have test on glucuronidated androgen metabolites, as such are not routine measurements in clinical practice. (biomedcentral.com)
  • A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta 5 -steroid precursors to 3-oxo-Delta 4 -steroids, an essential step in steroid hormone biosynthesis. (uniprot.org)
  • Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. (uniprot.org)
  • 3. The measurement of steroids in prostatic tissues provides a more reliable index for separating malignant from benign hypertrophied tissues. (springer.com)
  • Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). (abcam.com)
  • Time course studies using 10 nM labeled testosterone, 3 alpha-DIOL, 3 beta-DIOL, or ADT showed that a large proportion of polar steroids were produced by LNCaP. (nih.gov)
  • Planar C18 and C19 steroids with a 17α -hydroxyl group bind particularly well, whereas C19 17-ketosteroids such as dehydroepiandrosterone (DHEA) and androstendione do not bind so easily. (cdc.gov)
  • The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. (gentaur.com)
  • GENTAUR antibody-antibodies.com The Marketplace for Antibodies : The androgen metabolite, 5α-androstane-3β,17β-diol, decreases cytokine-induced cyclooxygenase-2, vascular cell adhesion molecule-1 expression, and P-glycoprotein expression in male human brain microvascular endothelial cells. (antibody-antibodies.com)
  • The androgen metabolite, 5α-androstane-3β,17β-diol, decreases cytokine-induced cyclooxygenase-2, vascular cell adhesion molecule-1 expression, and P-glycoprotein expression in male human brain microvascular endothelial cells. (antibody-antibodies.com)
  • The principal metabolite of DHT, 5α-androstane-3β,17β-diol (3β-diol), activates estrogen receptor (ER)β and similarly decreases inflammatory markers in vascular cells. (antibody-antibodies.com)
  • Based on the high concentration of 3β-diol and since this metabolite is a physiological ERβ ligand, we hypothesized that 3β-diol would be involved in the regulation of ERβ expression. (illinois.edu)
  • Let's review some of the research about this anti-carcinogenic testosterone named 3β-Adiol (for the technically inclined, the "full name" of this testosterone metabolite is in parentheses above). (anh-usa.org)
  • Why isn't this "novel potential application" of 3β-Adiol-a testosterone metabolite produced internally in every male body-why isn't it being heavily researched and freely used-right here in these United States? (anh-usa.org)
  • that 3 β- Adiol be made available again to compounding pharmacies so our physicians can once again prescribe this safe natural, bio-identical testosterone metabolite for any man who may have a family history of prostate cancer or any other testosterone related cancer! (anh-usa.org)
  • Using RT-qPCR, the mRNAs for AR, ERα, and ERβ and steroid metabolizing enzymes necessary for DHT conversion to 3β-diol were detected in male HBMECs demonstrating that the enzymes and receptors for production of and responsiveness to 3β-diol are present. (antibody-antibodies.com)
  • 17α-Ethynyl-3α-androstanediol itself shows very low affinity for steroid receptors, including the AR, ERα, ERβ, PR, and GR, and its mechanism of action is not well-characterized. (wikipedia.org)
  • Since then, several other routes have been discovered that lead to 11-oxyandrogens [3] which are potent agonists of the androgen receptors. (wikiversity.org)
  • [3] During pregnancy , due to activation of SHBG production in the liver by high estrogen levels, SHBG levels increase by 5- to 10-fold. (wikidoc.org)
  • Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA). (wikipedia.org)
  • Gustafsson: Estrogen receptor β exon 3-deleted mouse: The importance of non-ERE pathways in ERβ signaling. (uh.edu)
  • 3β-Diol is a selective, potent, high- affinity full agonist of the ERβ , and hence, an estrogen . (wikipedia.org)
  • Derivatives and analogues of androstenediol, such as the 17α-substituted methandriol (17α-methylandrostenediol) and ethinylandrostenediol (17α-ethynylandrostenediol) as well as the naturally occurring 19-norandrostane derivative norandostenediol (19-nor-5-androstenediol), have been synthesized and studied. (wikipedia.org)
  • Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5α-androstane-3α,17β-diol derivatives. (biomedsearch.com)
  • Androstenedione, oestradiol-17β and T were found to be significantly higher in malignant prostates, whilst DHT was higher in benign hypertrophied tissues. (springer.com)
  • The primary pathway involves conversion of 17α-hydroxypregnenolone to DHEA by way of 17,20-lyase, with subsequent conversion of DHEA to androstenedione via the enzyme 3β-hydroxysteroid dehydrogenase. (wikipedia.org)
  • The secondary pathway involves conversion of 17α-hydroxyprogesterone, most often a precursor to cortisol, to androstenedione directly by way of 17,20-lyase. (wikipedia.org)
  • Thus, 17,20-lyase is required for the synthesis of androstenedione, whether immediately or one step removed. (wikipedia.org)
  • In premenopausal women, the adrenal glands and ovaries each produce about half of the total androstenedione (about 3 mg/day). (wikipedia.org)
  • Conversion of androstenedione to testosterone requires the enzyme 17β-hydroxysteroid dehydrogenase. (wikipedia.org)
  • [3] Dehydroepiandrosterone (DHEA) is weakly bound to SHBG, but dehydroepiandrosterone sulfate is not bound to SHBG. (wikidoc.org)
  • The character of R, of course, depends ing material dehydroepiandrosterone (A5-androstene-3B on the particular acylating agent utilized for the third ol-17-one), as Well as for the production of di-hydrostestos step of the above set-forth reaction. (docme.ru)
  • Androstenediol possesses potent estrogenic activity, similarly to DHEA and 3β-androstanediol. (wikipedia.org)
  • In men, DHEA administration caused 175%, 90%, 200% and 120% increases in the circulating levels of DHEA and its sulfate (DHEA-S), DHEA-fatty acid esters, and androst-5-ene-3 beta,17 beta-diol, respectively, with a return to basal values 7 days after cessation of the 14-day treatment. (anabolicminds.com)
  • [3] In women, SHBG serves to limit exposure to both androgens and estrogens . (wikidoc.org)
  • [3] Low SHBG levels in women have been associated with hyperandrogenism and endometrial cancer due to heightened exposure to androgens and estrogens, respectively. (wikidoc.org)
  • [3] The high SHBG levels during pregnancy may serve to protect the mother from exposure to fetal androgens that escape metabolism by the placenta . (wikidoc.org)
  • Our results indicate metabolism of maternal androgens, very likely to 5β-androstane-3α,17β-diol, etiocholanolone and their conjugated forms. (biologists.org)
  • MBS7235953 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • 17α-Ethynyl-3α-androstanediol (developmental code names HE-3235, Apoptone), also known as 17α-ethynyl-5α-androstane-3α,17β-diol, is a synthetic androstane steroid and a 17α-substituted derivative of 3α-androstanediol which was never marketed. (wikipedia.org)
  • The first step of this route is conversion of 17-OHP by 5α-reductase enzymes, the 3-oxo-5α-steroid 4-dehydrogenase type 1 (SRD5A1) and type 2 (SRD5A2), to 5α-pregnan-17α-ol-3,20-dione, also known as 17α-hydroxy-dihydroprogesterone (17‐OH-DHP). (wikiversity.org)
  • A determination of the circulating levels of 3β-diol in humans found concentrations of 239 ± 76 pg/ml and 82 ± 45 pg/ml of the compound in normal male and female serum , respectively. (wikipedia.org)
  • The genetic variation of SRD5A2 is associated with circulating 3-diol-3G and 3-diol-17G concentrations in Chinese elderly men. (scialert.net)
  • Analogues of 17α-ethynyl-3α-androstanediol include 17α-ethynyl-3β-androstanediol, ethinylandrostenediol (17α-ethynyl-5-androstenediol), ethandrostate (17α-ethynyl-5-androstenediol 3β-cyclohexanepropionate), ethinylestradiol (17α-ethynylestradiol), ethisterone (17α-ethynyltestosterone), and 5α-dihydroethisterone (17α-ethynyldihydrotestosterone). (wikipedia.org)
  • Androstenediol, also known as androst-5-ene-3β,17β-diol, is a naturally occurring androstane steroid. (wikipedia.org)
  • It is closely related to androstenediol (androst-5-ene-3β,17β-diol). (wikipedia.org)
  • Ghanadian R, Puah CM (1981) Age-related changes of serum 5α-androstane-3α,17β-diol in normal men. (springer.com)
  • Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). (abcam.com)
  • This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. (nih.gov)
  • Gandy HM, Peterson RE (1968) Measurements of testosterone and 17-ketosteroids in plasma by the double isotope dilution derivative technique. (springer.com)
  • 1,1'-(Azodicarbonyl)dipiperidine (CAS 10465-81-3) Market Research Report 2018 contents were prepared and placed on the website in April, 2018. (marketpublishers.com)
  • Please note that 1,1'-(Azodicarbonyl)dipiperidine (CAS 10465-81-3) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • In an attempt to understand early events in ovarian carcinogenesis, and to explore steps in its progression, we have applied multiple molecular genetic techniques to the analysis of 21 early-stage (stage I/II) and 17 advanced-stage (stage III/IV) ovarian tumors. (aacrjournals.org)
  • To extend our understanding of any stepwise genetic alterations that may underlie the assumed clinical progression from early- to late-stage ovarian cancer, CGH 3 (14) was used to identify regions of genome loss and gain in the same series of tumors. (aacrjournals.org)
  • Consequently, the drug-testing paradigm established in the 1960s cannot prevent elite athletes from doping with impunity when using many potent doping substances such as designer recombinant erythropoietin (rEPO) 3 and designer testosterone. (aaccjnls.org)
  • 3β-Diol appears to be the endogenous ligand of ERβ in the prostate gland , and as a result of activation of the ERβ, 3β-diol has antiproliferative effects against prostate cancer cells . (wikipedia.org)
  • Acylating Agent H_ O:O l Aluminum Alkoxide Hydrogen Acceptor 17-'hydroxy progesterone and to a novel method for the 2.5 production of a new cortical hormone A'LIG-pregnadien OR 3,20-dione-2l-ol and its esters. (docme.ru)
  • 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. (gentaur.com)
  • Because AR coactivators enhance transactivation of AR, in this report we evaluated the relationship of a CAG/CAA repeat length polymorphism in the AIB1/SRC-3 gene (amplified in breast cancer gene 1, a steroid receptor coactivator and an AR coactivator) with prostate cancer risk in a population-based case-control study in China. (aacrjournals.org)
  • Together, our data indicate that the CAG/CAA repeat length in the AIB1/SRC-3 gene may be associated with prostate cancer risk in Chinese men and that the combination of CAG/CAA repeat lengths in both the AIB1/SRC-3 and AR genes may provide a useful marker for clinically significant prostate cancer. (aacrjournals.org)
  • Expanded studies in other populations are needed to confirm this association and the combined effect of AIB1/SRC-3 and other hormone-related genes in prostate cancer etiology. (aacrjournals.org)
  • Researchers previously had reported 4 that 3β-Adiol inhibits prostate cancer cell migration by activating…guess what…ERβ. (anh-usa.org)
  • In 2010, other very promising research reported 5 that 3β-Adiol decreased the proliferation rate of prostate cancer cells and reduced their invasiveness into prostate tissue. (anh-usa.org)
  • We conclude that NAT1 expression is not directly regulated by E 2 , DHT, 3 β -adiol, or dithiothreitol despite high NAT1 and ESR1 expression in luminal A breast cancer cells, suggesting that ESR1 , XBP1, and NAT1 expression may share a common transcriptional network arising from the luminal epithelium associated with better survival in breast cancer. (aspetjournals.org)
  • OVCAR-3 and OAW-42 ovarian cancer cells were treated with the ERβ agonists ERB-041, WAY200070, Liquiritigenin and 3β-Adiol and cell growth was measured by means of the Cell Titer Blue Assay (Promega). (biomedcentral.com)
  • Recently, we investigated the effect of ERβ overexpression on the SK-OV-3 ovarian cancer cells. (biomedcentral.com)
  • For a few months, bio-identical "3β-Adiol" (longer name "5α-androstane-3β,17β-diol") could be prescribed and compounded with "regular" testosterone, a combination particularly useful to men with a family history of prostate or other testosterone related cancer. (anh-usa.org)
  • [3] 3β-Diol has been reported to also bind to ERα with low nanomolar affinity, with several-fold lower affinity relative to ERβ. (wikipedia.org)
  • On the other hand, SNP rs12470143 was found to be significantly correlated with 3-diol-3G concentration ( P = 0.021). (scialert.net)
  • The gene for SHBG is called Shbg located on chromosome 17 [11] on the short arm between the bands 17p12→p13. (wikipedia.org)
  • Rs6259, also called Asp327Asn location 7633209 on Chromosome 17, results in there being an extra N-glycosilation site, and so an extra sugar can be attached. (wikipedia.org)
  • Rs6258 also called Ser156Pro is at position 7631360 on the Chromosome 17. (wikipedia.org)
  • Expected to use NAD + as preferred electron donor for the 3-beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity. (uniprot.org)
  • T(3) rapidly regulates several steps of alpha subunit glycoprotein (CGA) synthesis and secretion in the pituitary of male rats: potential repercussions on TSH, FSH and LH secretion. (publish.csiro.au)
  • Dr. Eckery spent 17 years in New Zealand researching the reproductive biology of the brushtail possum and investigating methods of fertility control for this species, and he played a key role in establishing the National Research Centre for Possum Biocontrol. (usda.gov)
  • Genotyping of the 3 SRD5A2 tagSNPs [rs3731586, rs12470143, and rs523349 (V89L)] was performed by using melting-temperature-shift allele-specific PCR. (scialert.net)
  • The well-described SRD5A2 missense variant rs523349 (V89L) was modestly associated with the 3-diol-17G concentration ( P = 0.040). (scialert.net)
  • In addition, we showed that SRD5A2 haplotypic association, rather than a single SNP alone, might be a better predictor of the 3-diol-G concentration. (scialert.net)
  • Furthermore, given the drawbacks of 17α-hydroxylase inhibition, there is considerable interest in developing new CYP17A1 inhibitors that more specifically inhibit lyase activity and are therefore less likely to require glucocorticoid coadministration. (aacrjournals.org)
  • androst-5-en-3β-ol-17-one), and testosterone (androst-4-en-17β-ol-3-one), as well as to 3β-androstanediol (5α-androstane-3β,17β-diol). (wikipedia.org)
  • 3β-Androstanediol , also known as 5α-androstane-3β,17β-diol , and often shortened to 3β-diol , is an endogenous steroid hormone . (wikipedia.org)
  • [6] [ contradictory ] Unlike its 3α-isomer, 3α-androstanediol (3α-diol), 3β-diol does not bind to the GABA A receptor . (wikipedia.org)
  • Furthermore, diabetic patients (both men and women) under cyclosporine A therapy have shown increased 3α-Diol G levels, a side effect resulting in the appearance of hair in previously hairless areas. (eaglebio.com)
  • Replacement with 3β-diol-induced the highest levels of ERβ, but was comparatively less effective in recovering the AR expression and the gland structure. (illinois.edu)
  • To get these benefits, you need adequate levels of omega-3 fatty acids in the blood. (zonediet.com)
  • The Cellular Inflammation Test can determine the levels of omega-3 fatty acids in the blood required for optimal resolution of inflammation. (zonediet.com)
  • Both ERα and ERβ are differentially expressed in adult prostatic tissues, with the epithelial cells expressing mainly ERβ whereas the stromal cells expressing ERα at low levels ( 3 ). (aacrjournals.org)
  • There was age-related decline in performance of the inhibitory avoidance, water maze, defensive freezing, and forced swim tasks, and hippocampal 3α-diol levels. (frontiersin.org)