Pneumoconiosis: A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.Mycobacterium Infections, Nontuberculous: Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.Mycobacterium Infections: Infections with bacteria of the genus MYCOBACTERIUM.Bronchiectasis: Persistent abnormal dilatation of the bronchi.DenmarkNontuberculous Mycobacteria: So-called atypical species of the genus MYCOBACTERIUM that do not cause tuberculosis. They are also called tuberculoid bacilli, i.e.: M. buruli, M. chelonae, M. duvalii, M. flavescens, M. fortuitum, M. gilvum, M. gordonae, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. kansasii, M. marinum, M. obuense, M. scrofulaceum, M. szulgai, M. terrae, M. ulcerans, M. xenopi.Respiratory Tract DiseasesMycobacterium: A genus of gram-positive, aerobic bacteria. Most species are free-living in soil and water, but the major habitat for some is the diseased tissue of warm-blooded hosts.Budesonide: A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Trans-Cinnamate 4-Monooxygenase: A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropanoid pathway in higher PLANTS by transforming trans-cinnamate into p-coumarate.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.STAT3 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Suspensions: Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.p38 Mitogen-Activated Protein Kinases: A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.Thrombopoietin: A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Protein-Tyrosine Kinases: Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.Receptors, Collagen: Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.Phosphatidylinositol 3-Kinases: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Androstadienes: Derivatives of the steroid androstane having two double bonds at any site in any of the rings.Potassium Channels, Inwardly Rectifying: Potassium channels where the flow of K+ ions into the cell is greater than the outward flow.Sulfonylurea Receptors: ATP-BINDING CASSETTE PROTEINS that are highly conserved and widely expressed in nature. They form an integral part of the ATP-sensitive potassium channel complex which has two intracellular nucleotide folds that bind to sulfonylureas and their analogs.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.KATP Channels: Heteromultimers of Kir6 channels (the pore portion) and sulfonylurea receptor (the regulatory portion) which affect function of the HEART; PANCREATIC BETA CELLS; and KIDNEY COLLECTING DUCTS. KATP channel blockers include GLIBENCLAMIDE and mitiglinide whereas openers include CROMAKALIM and minoxidil sulfate.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.Receptors, Drug: Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.Glyburide: An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.ATP-Binding Cassette Transporters: A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.Sulfonylurea CompoundsPotassium Channel Blockers: A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.Endosomal Sorting Complexes Required for Transport: A set of protein subcomplexes involved in PROTEIN SORTING of UBIQUITINATED PROTEINS into intraluminal vesicles of MULTIVESICULAR BODIES and in membrane scission during formation of intraluminal vesicles, during the final step of CYTOKINESIS, and during the budding of enveloped viruses. The ESCRT machinery is comprised of the protein products of Class E vacuolar protein sorting genes.Endosomes: Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.PhosphoproteinsProtein Transport: The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.Endocytosis: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.Hepatocyte Growth Factor: Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Multilingualism: The ability to speak, read, or write several languages or many languages with some facility. Bilingualism is the most common form. (From Random House Unabridged Dictionary, 2d ed)Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Language: A verbal or nonverbal means of communicating ideas or feelings.Vocabulary: The sum or the stock of words used by a language, a group, or an individual. (From Webster, 3d ed)ReadingPhonetics: The science or study of speech sounds and their production, transmission, and reception, and their analysis, classification, and transcription. (Random House Unabridged Dictionary, 2d ed)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. (1/2714)

Interaction between integrin alphavbeta3 and extracellular matrix is crucial for endothelial cells sprouting from capillaries and for angiogenesis. Furthermore, integrin-mediated outside-in signals co-operate with growth factor receptors to promote cell proliferation and motility. To determine a potential regulation of angiogenic inducer receptors by the integrin system, we investigated the interaction between alphavbeta3 integrin and tyrosine kinase vascular endothelial growth factor receptor-2 (VEGFR-2) in human endothelial cells. We report that tyrosine-phosphorylated VEGFR-2 co-immunoprecipitated with beta3 integrin subunit, but not with beta1 or beta5, from cells stimulated with VEGF-A165. VEGFR-2 phosphorylation and mitogenicity induced by VEGF-A165 were enhanced in cells plated on the alphavbeta3 ligand, vitronectin, compared with cells plated on the alpha5beta1 ligand, fibronectin or the alpha2beta1 ligand, collagen. BV4 anti-beta3 integrin mAb, which does not interfere with endothelial cell adhesion to vitronectin, reduced (i) the tyrosine phosphorylation of VEGFR-2; (ii) the activation of downstream transductor phosphoinositide 3-OH kinase; and (iii) biological effects triggered by VEGF-A165. These results indicate a new role for alphavbeta3 integrin in the activation of an in vitro angiogenic program in endothelial cells. Besides being the most important survival system for nascent vessels by regulating cell adhesion to matrix, alphavbeta3 integrin participates in the full activation of VEGFR-2 triggered by VEGF-A, which is an important angiogenic inducer in tumors, inflammation and tissue regeneration.  (+info)

Activation of c-Jun N-terminal kinase 1 by UV irradiation is inhibited by wortmannin without affecting c-iun expression. (2/2714)

Activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases is an early response of cells upon exposure to DNA-damaging agents. JNK-mediated phosphorylation of c-Jun is currently understood to stimulate the transactivating potency of AP-1 (e.g., c-Jun/c-Fos; c-Jun/ATF-2), thereby increasing the expression of AP-1 target genes. Here we show that stimulation of JNK1 activity is not a general early response of cells exposed to genotoxic agents. Treatment of NIH 3T3 cells with UV light (UV-C) as well as with methyl methanesulfonate (MMS) caused activation of JNK1 and an increase in c-Jun protein and AP-1 binding activity, whereas antineoplastic drugs such as mafosfamide, mitomycin C, N-hydroxyethyl-N-chloroethylnitrosourea, and treosulfan did not elicit this response. The phosphatidylinositol 3-kinase inhibitor wortmannin specifically blocked the UV-stimulated activation of JNK1 but did not affect UV-driven activation of extracellular regulated kinase 2 (ERK2). To investigate the significance of JNK1 for transactivation of c-jun, we analyzed the effect of UV irradiation on c-jun expression under conditions of wortmannin-mediated inhibition of UV-induced stimulation of JNK1. Neither the UV-induced increase in c-jun mRNA, c-Jun protein, and AP-1 binding nor the activation of the collagenase and c-jun promoters was affected by wortmannin. In contrast, the mitogen-activated protein kinase/ERK kinase inhibitor PD98056, which blocked ERK2 but not JNK1 activation by UV irradiation, impaired UV-driven c-Jun protein induction and AP-1 binding. Based on the data, we suggest that JNK1 stimulation is not essential for transactivation of c-jun after UV exposure, whereas activation of ERK2 is required for UV-induced signaling leading to elevated c-jun expression.  (+info)

Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates. (3/2714)

Activation of the extracellularly regulated kinase (ERK) pathway is part of the early biochemical events that follow lipopolysaccharide (LPS) treatment of macrophages or their infection by virulent and attenuated Salmonella strains. Phagocytosis as well as the secretion of invasion-associated proteins is dispensable for ERK activation by the pathogen. Furthermore, the pathways used by Salmonella and LPS to stimulate ERK are identical, suggesting that kinase activation might be solely mediated by LPS. Both stimuli activate ERK by a mechanism involving herbimycin-dependent tyrosine kinase(s) and phosphatidylinositol 3-kinase. Phospholipase D activation and stimulation of protein kinase C appear to be intermediates in this novel pathway of MEK/ERK activation.  (+info)

Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor. (4/2714)

The mechanism by which growth factors exert an anti-apoptotic function on many cell types is not well understood. This issue is addressed in relation to epidermal growth factor (EGF) which inhibits apoptosis induced by staurosporine or wortmannin in an epithelial tumour cell line (CNE-2). The presence of EGF substantially reduced the in vitro Ac-DEVD-AMC hydrolytic activity and almost completely suppressed the intracellular cleavage of poly(ADP-ribose) polymerase in staurosporine- or wortmannin-treated cells. Staurosporine but not wortmannin caused the intracellular proteolytic processing of pro-caspase-3 and this event was transiently inhibited by EGF. Staurosporine-induced apoptosis was not inhibited by EGF in the presence of wortmannin or LY294002. Similarly, EGF failed to inhibit wortmannin-induced apoptosis in the presence of staurosporine, chelerythrine chloride or Go6850. These results suggest that phosphatidylinositol 3-kinase and protein kinase C play a role in the survival function of EGF but the reduction of cellular caspase activity cannot be satisfactorily explained by a lack of pro-caspase-3 activation.  (+info)

Nerve growth factor induces zif268 gene expression via MAPK-dependent and -independent pathways in PC12D cells. (5/2714)

In this study we examined the contribution of MAPK1 and 2 [also known as extracellular signal-regulated kinases (ERK)-1 and 2] to the induction of zif268 mRNA in PC12D cells by using two methods to block the activation of these kinases. In one set of experiments, we inhibited the activation of MAPK by pretreating cells with PD098059, a specific inhibitor of MEK (MAPKK), the immediate upstream activator of MAPK. In the second set of experiments, we blocked the activation of MAPK by overexpressing N17Ras, a dominant-negative form of Ha-Ras. These two approaches yielded similar results and showed that inhibition of MAPK blocks less than half of the induction of zif268 mRNA by NGF. Much of the residual induction of zif268 mRNA is blocked by low concentrations of wortmannin, an inhibitor of phosphatidylinositol (PI) 3-kinase. Since PI 3-kinase was previously shown to function upstream in epidermal growth factor (EGF)-mediated activation of c-Jun N-terminal kinase (JNK), and JNK is known to phosphorylate and activate transcription factors that regulate the expression of zif268, we investigated the role of JNK in the induction of zif268 mRNA by NGF. Stimulation of PC12D cells with NGF weakly activates JNK, but this activation is enhanced rather than inhibited by pretreatment with wortmannin, suggesting that JNK does not function downstream of PI 3-kinase in the induction of zif268 mRNA. A role for JNK in the induction of the zif268 gene is indicated, however, by the fact that cotransfection of expression vectors encoding JIP-1 or the JNK binding domain of JIP-1, which act as dominant-negative inhibitors of JNK, partially blocks the NGF-mediated induction of a luciferase reporter gene linked to the zif268 promoter. Together, these results suggest that MAPK, PI-3 kinase and JNK each play a role in the induction of zif268 gene expression by NGF in PC12D cells.  (+info)

Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. (6/2714)

Phosphoinositide 3-kinases (PI3Ks) are lipid kinases which also possess an in vitro protein kinase activity towards themselves or their adaptor proteins. The physiological relevance of these phosphorylations is unclear at present. Here, the protein kinase activity of the tyrosine kinase-linked PI3K, p110delta, is characterized and its functional impact assessed. In vitro autophosphorylation of p110delta completely down-regulates its lipid kinase activity. The single site of autophosphorylation was mapped to Ser1039 at the C-terminus of p110delta. Antisera specific for phospho-Ser1039 revealed a very low level of phosphorylation of this residue in cell lines. However, p110delta that is recruited to activated receptors (such as CD28 in T cells) shows a time-dependent increase in Ser1039 phosphorylation and a concomitant decrease in associated lipid kinase activity. Treatment of cells with okadaic acid, an inhibitor of Ser/Thr phosphatases, also dramatically increases the level of Ser1039-phosphorylated p110delta. LY294002 and wortmannin blocked these in vivo increases in Ser1039 phosphorylation, consistent with the notion that PI3Ks, and possibly p110delta itself, are involved in the in vivo phosphorylation of p110delta. In summary, we show that PI3Ks are subject to regulatory phosphorylations in vivo similar to those identified under in vitro conditions, identifying a new level of control of these signalling molecules.  (+info)

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. (7/2714)

Replication protein A (RPA) is a DNA single-strand binding protein essential for DNA replication, recombination and repair. In human cells treated with the topoisomerase inhibitors camptothecin or etoposide (VP-16), we find that RPA2, the middle-sized subunit of RPA, becomes rapidly phosphorylated. This response appears to be due to DNA-dependent protein kinase (DNA-PK) and to be independent of p53 or the ataxia telangiectasia mutated (ATM) protein. RPA2 phosphorylation in response to camptothecin required ongoing DNA replication. Camptothecin itself partially inhibited DNA synthesis, and this inhibition followed the same kinetics as DNA-PK activation and RPA2 phosphorylation. DNA-PK activation and RPA2 phosphorylation were prevented by the cell-cycle checkpoint abrogator 7-hydroxystaurosporine (UCN-01), which markedly potentiates camptothecin cytotoxicity. The DNA-PK catalytic subunit (DNA-PKcs) was found to bind RPA which was replaced by the Ku autoantigen upon camptothecin treatment. DNA-PKcs interacted directly with RPA1 in vitro. We propose that the encounter of a replication fork with a topoisomerase-DNA cleavage complex could lead to a juxtaposition of replication fork-associated RPA and DNA double-strand end-associated DNA-PK, leading to RPA2 phosphorylation which may signal the presence of DNA damage to an S-phase checkpoint mechanism. KEYWORDS: camptothecin/DNA damage/DNA-dependent protein kinase/RPA2 phosphorylation  (+info)

A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf. (8/2714)

Cytokines trigger the rapid assembly of multimolecular signaling complexes that direct the activation of downstream protein kinase cascades. Two protein kinases that have been linked to growth factor-regulated proliferation and survival are mitogen-activated protein/ERK kinase (MEK) and its downstream target Erk, a member of the mitogen-activated protein kinase family. Using complementary pharmacological and genetic approaches, we demonstrate that MEK and Erk activation requires a phosphatidylinositol 3-kinase (PI3-K)-generated signal in an interleukin (IL)-3-dependent myeloid progenitor cell line. Analysis of the upstream pathway leading to MEK activation revealed that inhibition of PI3-K did not block c-Raf activation, whereas MEK activation was effectively blocked under these conditions. Furthermore, agents that elevated cAMP suppressed IL-3-induced c-Raf activation but did not inhibit MEK activation. Because c-Raf activation and MEK activation were inversely affected by PI3-K- and cAMP-dependent pathways, we examined whether IL-3 activated the alternative Raf isoforms A-Raf and B-Raf. Although IL-3 did not activate B-Raf, A-Raf was activated by the cytokine. Moreover, A-Raf activation, like MEK activation, was blocked by inhibition of PI3-K but was insensitive to cAMP. Experiments with dominant negative mutants of the Raf isoforms showed that overexpression of dominant negative c-Raf did not prevent MEK activation. However, dominant negative A-Raf effectively blocked MEK activation, suggesting that activation of the MEK-Erk signaling cascade is mediated through A-Raf. Taken together, these results suggest that IL-3 receptors engage and activate both c-Raf and A-Raf in hemopoietic cells. However, these intermediates are differentially regulated by upstream signaling cascades and selectively coupled to downstream signaling pathways.  (+info)

Absorption:Fluticasone Propionate:Healthy Subjects: Fluticasone propionate acts locally in the lung; therefore, plasma levels do not predict therapeutic effect. Studies using oral dosing of labeled and unlabeled drug have demonstrated that the oral systemic bioavailability of fluticasone propionate is negligible (,1%), primarily due to incomplete absorption and presystemic metabolism in the gut and liver. In contrast, the majority of the fluticasone propionate delivered to the lung is systemically absorbed.. Following administration of ADVAIR DISKUS to healthy adult subjects, peak plasma concentrations of fluticasone propionate were achieved in 1 to 2 hours. In a single-dose crossover study, a higher-than-recommended dose of ADVAIR DISKUS was administered to 14 healthy adult subjects. Two (2) inhalations of the following treatments were administered: ADVAIR DISKUS 500/50, fluticasone propionate powder 500 mcg and salmeterol powder 50 mcg given concurrently, and fluticasone propionate powder 500 ...
Evaluation of Fluticasone Propionate and Fluticasone Propionate/Salmeterol Combination on Exercise in Pediatric and Adolescent Patients with Asthma
Absorption Fluticasone Propionate: Healthy Subjects: Fluticasone propionate acts locally in the lung; therefore, plasma levels do not predict therapeutic effect. Trials using oral dosing of labeled and unlabeled drug have demonstrated that the oral systemic bioavailability of fluticasone propionate is negligible (,1%), primarily due to incomplete absorption and presystemic metabolism in the gut and liver. In contrast, the majority of the fluticasone propionate delivered to the lung is systemically absorbed.. Three (3) single-dose, placebo-controlled, crossover trials were conducted in healthy subjects: (1) a trial using 4 inhalations of ADVAIR HFA 230/21, salmeterol CFC inhalation aerosol 21 mcg, or fluticasone propionate CFC inhalation aerosol 220 mcg, (2) a trial using 8 inhalations of ADVAIR HFA 45/21, ADVAIR HFA 115/21, or ADVAIR HFA 230/21, and (3) a trial using 4 inhalations of ADVAIR HFA 230/21; 2 inhalations of ADVAIR DISKUS 500/50; 4 inhalations of fluticasone propionate CFC inhalation ...
Long-term use of fluticasone propionate/salmeterol fixed-dose combination and incidence of cataracts and glaucoma among chronic obstructive pulmonary disease patients in the UK General Practice Research Database David P Miller, Stephanie E Watkins, Tim Sampson, Kourtney J Davis WorldWide Epidemiology, GlaxoSmithKline, Durham, NC, USA Objectives: Some large population-based studies have reported a dose-related increased risk of cataracts and glaucoma associated with use of inhaled corticosteroids (ICS) in patients with asthma or chronic obstructive pulmonary disease (COPD). We evaluated the association between use of ICS-containing products, specifically fluticasone propionate/salmeterol fixed-dose combination (FSC), and incidence of cataracts and glaucoma among patients with COPD in a large electronic medical record database in the United Kingdom. Methods: We identified a cohort of patients aged 45 years and over with COPD in the General Practice Research Database (GPRD) between 2003 and 2006. Cases of
This is a multicenter, randomized, double-blind, double-dummy, parallel group study. The purpose of this study is to compare the efficacy and safety of umeclidinium/vilanterol (UMEC/VI) and fluticasone propionate/salmeterol (FSC) in subjects with Chronic Obstructive Pulmonary Disease (COPD). Subjects who meet the eligibility criteria at Screening will complete a 7 to 14 day Run-in period. At the end of the run-in period, approximately 710 eligible subjects will be equally randomized (to complete at least 568 evaluable subjects) to one of the 2 treatment groups for 12 weeks: 1. UMEC/VI 62.5/25 micrograms (mcg) administered as one inhalation once-daily in the morning via the Novel dry powder inhaler (NDPI) + placebo administered as one inhalation each morning and evening via single multidose powdered inhaler (ACCUHALER/DISKUS) or 2. FSC 500/50 mcg administered as one inhalation each morning and evening via ACCUHALER/DISKUS + placebo administered once-daily in the morning via NDPI. A safety ...
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Key clinical point: Patients with chronic obstructive pulmonary disease (COPD) fared better on an inhaled fixed-dose long-acting muscarinic antagonist/long-acting β2-agonist vs. an inhaled corticosteroid.Major finding: Patients who began umeclidinium/vilanterol (62.5/25 msg) therapy were less likely to progress to multiple-inhaler triple therapy (hazard ratio = 0.65; 95% CI, 0.47-0.89; P = .008) vs. fluticasone propionate/salmeterol (250/50 msg).
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Allergic rhinitis is an inflammation of the nasal airways due to allergens, such as dust, animal dander and pollen. Overall, those with allergic rhinitis have a sensitized immune system. The allergen produces the antibody immunoglobulin E and typically causes symptoms like rashes, flu, watery eyes, itching and sneezing. Fluticasone propionate nasal spray is an intranasal corticosteroid to treat those with allergic rhinitis.. When the nasal passages are exposed to allergens, the cells in the nose begin to release chemicals that produce an allergic response. When the fluticasone propionate nasal spray is used, the fluticasone is absorbed directly by the cells. It prevents these cells from triggering the chemicals that cause an allergic response. However, fluticasone propionate doesnt work right away; it can take up to four days to get the full effect. This is why doctors recommend using it prior to the allergy season, such as spring pollen. It also needs to be used on a regular basis to keep ...
TY - JOUR. T1 - Asthma exacerbations in African Americans treated for 1 year with combination fluticasone propionate and salmeterol or fluticasone propionate alone. AU - Bailey, William. AU - Castro, Mario. AU - Matz, Jonathan. AU - White, Martha. AU - Dransfield, Mark. AU - Yancey, Steve. AU - Ortega, Hector. PY - 2008/6/1. Y1 - 2008/6/1. N2 - Objective: This long-term prospective study was conducted in African Americans with persistent asthma to examine the safety and effectiveness of the combination of the inhaled corticosteroid, fluticasone propionate (FP), and the long-acting beta-agonist, salmeterol, compared with FP alone. Research and design methods: This was a randomized, double-blind, parallel group, multi-center trial in adolescent and adult subjects ≥12 years of age symptomatic on a low dose of an inhaled corticosteroid (ICS). The study consisted of a 2-week screening period on low dose ICS; a 4-week open-label FP 250 mcg twice daily (BID) run-in; a 52-week double-blind period ...
FLUTICASONE PROPIONATE INTERMEDIATE 80474-45-9 NMR spectrum, FLUTICASONE PROPIONATE INTERMEDIATE H-NMR spectral analysis, FLUTICASONE PROPIONATE INTERMEDIATE C-NMR spectral analysis ect.
The purpose of this study is to assess whether the risk of serious asthma-related events (asthma-related hospitalizations, endotracheal intubations, and deaths)
Hanmi Pharmaceutical is developing an inhaled, fixed-dose combination, containing the small-molecules salmeterol and fluticasone propionate for the treatment of
Australia. Adverse Drug Reactions Advisory Committee (ADRAC) in Australia has received 10 reports of inhaled corticosteroid-associated adrenal crisis. Eight cases involved children aged 3 10 years who had received fluticasone propionate (Flixotide) 250 1500 µg/day; in six cases, the daily dose was , 500µg, the upper limit recommended by The Thoracic Society of Australia and New Zealand and by The National Asthma Council in Australia, before referral to a respiratory physician. The committee notes that higher fluticasone propionate doses may not confer greater efficacy and prescribers are reminded that "inhaled corticosteroids should be given at the lowest effective dose and reviewed regularly".. Reports in WHO-file: Adrenal insufficiency 100. Reference: ...
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Aims: To investigate whether aerosol-type fluticasone propionate/formoterol combination (FFC) controls residual eosinophilic inflammation in the distal airways of well-controlled asthmatic patients more effectively than salmeterol/fluticasone propionate combination (SFC).. Methods: Subjects comprised 32 outpatients (61.9±17.0 years) with well-controlled moderate asthma who had used SFC for more than 4 weeks. Evidence of eosinophilic cationic protein (ECP) in 10% hypertonic saline-induced sputum was assessed, together with pulmonary function tests, respiratory resistance, exhaled nitric oxide (FeNO) and an Asthma Control Questionnaire (ACQ-5).. Results: ECP levels in late-phase sputum (117.6±144.7 mg/L at study entry) were significantly decreased 65.7±89.5 (p=0.019) at 4 weeks in the FFC group, but not in the SFC group. FeNo levels (44.8±23.5 ppb at study entry) were also significantly decreased to 37.8±23.5 (p=0.025) at 4 weeks in the FFC group. None of the indexes of pulmonary function ...
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TY - JOUR. T1 - Fluticasone propionate plasma concentration and systemic effect. T2 - Effect of delivery device and duration of administration. AU - Whelan, Glenn J.. AU - Blumer, Jeffrey L.. AU - Martin, Richard J.. AU - Szefler, Stanley J.. AU - Chinchilli, Vernon. AU - Kraft, Monica. AU - Dolovich, Myrna. AU - Boushey, Homer A.. AU - Cherniack, Reuben M.. AU - Craig, Timothy. AU - Drazen, Jeffrey M.. AU - Fagan, Joanne K.. AU - Fahy, John V.. AU - Fish, James E.. AU - Ford, Jean G.. AU - Israel, Elliott. AU - Kunselman, Susan J.. AU - Lazarus, Stephen C.. AU - Lemanske, Robert F.. AU - Peters, Stephen P.. AU - Sorkness, Christine A.. AU - King, Tonya. AU - Mauger, Elizabeth. PY - 2005/9/1. Y1 - 2005/9/1. N2 - Background: Inhaled corticosteroids are the preferred therapy in persistent asthma. Dry powder inhalers (DPIs) generate a larger particle size compared with metered-dose inhalers (MDIs), which affects pulmonary deposition, bioavailability, and subsequent systemic effects of fluticasone ...
Fluticasone propionate belongs to a class of drugs known as corticosteroids, specifically glucocorticoids, which are hormones that predominantly affect the metabolism of carbohydrates and, to a lesser extent, fat and protein. It is used to treat asthma, allergic rhinitis, nasal polyps, various skin disorders and Crohns disease and ulcerative colitis. It is also used to treat eosinophilic esophagitis. Fluticasone is used by powder or aerosol inhalation for the prophylaxis of asthma, the nasal spray is used for prophylaxis and treatment of allergic rhinitis, nasal drops are used in the treatment of nasal polyps, and creams and ointments are applied topically in the treatment of various skin disorders. It can be given orally in the treatment of Crohns disease and ulcerative colitis. Some benefit was also reported in coeliac disease.[citation needed] If taken correctly, the nasal spray and oral inhaler formulation have less corticosteroid side effects than the tablet formulation because they limit ...
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Fluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen , estrogen , or mineralocorticoid receptors , thereby producing anti-inflammatory and vasoconstriction effects. It has
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Inclusion Criteria for Entry in Treatment Period A subject will be considered eligible for inclusion in the treatment period only if he/she has completed the run-in period and meets the following criterion.. 1. Has been able, in the investigators/subinvestigators judgment, to make entries in the asthma diary and measure PEF, as directed, during the run-in period.. Exclusion criteria:. ...
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It is an inhaler used in bronchial asthma but not in acute attacks but as a prophylaxis to lower the intensity and frequency of the attacks.
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This study has produced several interesting findings that merit discussion and which together provide an explanation for much of the discrepancy between previous studies comparing the systemic activity of fluticasone propionate and budesonide. Firstly, healthy subjects had higher urinary TCM levels at baseline than the asthmatic subjects but lower levels after 7 days of treatment with fluticasone propionate. After 7 days of treatment with budesonide, however, urinary TCM levels remained above those in the asthmatic subjects. Secondly, the study highlights the differences in the sensitivity of markers used to assess systemic activity of inhaled corticosteroids, with urinary TCM being considerably more sensitive than morning serum cortisol or osteocalcin concentrations. Finally, our study raises the possibility that the relative effects of fluticasone propionate and budesonide on the HPA axis and bone metabolism may differ.. The large number of studies that have assessed the systemic activity of ...
Recent trials demonstrate increased pneumonia risk in chronic obstructive pulmonary disease patients treated with the inhaled corticosteroid (ICS) fluticasone propionate (FP). There is limited work describing FP effects on host defenses against bacterial pneumonia. C57BL/6 mice received daily, nose-only exposure to nebulized FP or vehicle for 8 days, followed by pulmonary challenge with Klebsiella pneumoniae. Bacterial burden, phagocytosis, leukocyte recruitment, cytokine expression, nitric oxide release, and survival were measured. Inhaled FP increased bacterial burden in lungs and blood 48 h after infection but affected neither in vivo phagocytosis of bacteria by alveolar macrophages (AM) nor alveolar neutrophil recruitment. AM from FP-treated mice showed impaired expression of infection induced TNF-alpha, IP-10 (CXCL-10), and interleukin 6 (IL-6), and AM also showed a trend towards impaired intracellular pathogen control following in vivo infection. In vitro FP treatment resulted in a dose-dependent
Background The inhaled corticosteroid (ICS) fluticasone propionate (fluticasone) and the long-acting β2-agonist (LABA) formoterol fumarate (formoterol) are being made available as a combination...
Status: Active. Support: Teva. Registration:. Short Description. The objective of this study is to investigate the real life effectiveness of ICS delivery of Fluticasone Propionate (FP) and Qvar® (beclomethasone dipropionate HFA) by pMDI with spacer compared to pMDI alone. Documents and Publications. Qvar_FD_Spacer_Protocol. Abstracts. Presentations. Final Publications. Additional Material. ...
Learn about three pivotal clinical studies that demonstrated DYMISTA (azelastine HCl/fluticasone propionate) Nasal Sprays efficacy
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Zhang, X., Moilanen, E. and Kankaanranta, H. (2000) Enhancement of human eosinophil apoptosis by fluticasone propionate, bude-sonide, and beclomethasone. European Journal of Pharmacology, 496, 325-332.doi10.1016/S0014-2999(00)00690-7
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Children with moderately severe asthma in accordance with the criteria of the American Thoracic Society,22 were enrolled in the study. They had bronchial hyperresponsiveness to inhaled methacholine23 and had been followed regularly in the Pediatric Allergy Clinic at the Faculty of Medicine, Ramathibodi Hospital, Mahidol University. Written informed consent for enrolment in the study was obtained from their parents or legal guardians. The study was approved by the Ethics Committee of the Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital.. All the patients were treated with inhaled fluticasone and bronchodilators. The dose of inhaled fluticasone was given according to the degree of response to a provocative concentration of methacholine as reported by Sont and colleagues.24 Inhaled fluticasone was given via a standard Volumatic spacer twice daily. Patients were trained to inhale the medication properly and rinse their mouths immediately after each inhalation. Medication ...
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Most premenopausal women with hormone receptor-positive breast cancer assigned to adjuvant treatment with the aromatase inhibitor exemestane plus triptorelin had large reductions in estrogen levels (estradiol [E2]) during the first year of treatment, …. ...
Aromasin (Exemestane) Aromasin is a steroidal aromatase inactivator used to lower circulating estrogen. It was developed to help fight breast cancer as estrogen plays a role in the growth of cancer cells. Aromasin binds irreversibly to the aromatase enzyme. This suppresses the conversion of androgens into estrogen. Circulating estrogen can be reduced by nearly 85% in women using Aromasin. A common misconception is that aromatase inhibition is similar in men than women. However in trials
If all three of the above are present a combination product delivering a twice-daily dose of 100 micrograms of fluticasone and 50 micrograms of salmeterol can be used for initial treatment. This is equivalent to two doses twice a day of the pMDI and one dose twice a day of the DPI. If any of the criteria above are not present a standard inhaled corticosteroid, for example beclometasone, should be used for initial treatment.. Once control is attained with the approach outlined above treatment should be reviewed and consideration given to stepping down to an inhaled corticosteroid alone in place of the combination product.. Action: Healthcare professionals should be aware of this change. This combination can be used to rapidly control asthma in suitable patients but treatment should be reviewed and stepped down once control is achieved.. ...
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Nepal M, Padma H.Fluticasone-associated cutaneous allergic granulomatous vasculitis: an underrecognised but important cause of drug-induced cutaneous Churg-Strauss syndrome. Southern Medical Journal 101: 761-763, No. 7, Jul 2008 - USAGoogle Scholar ...
Azelastine Hydrochloride (ay-ze-LAS-teen hye-droe-KLOR-ide), Fluticasone Propionate (floo-TIK-a-sone PROE-pee-oh-nate) Treats symptoms of hay fever (allergic rhinitis). This medicine contains an antihistamine and a steroid. Brand Name(s): Dymista, Ticalast
... Flonase is a medicine containing the corticosteriod fluticasone. It is used to treat nasal symptoms such as congestion, sneezing, and runny nose caused by seasonal or year-round allergies, asthma, eczema, psoriasis.
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Advair - Advair is a combination of two medicines (fluticasone and salmeterol) that are used to help control the symptoms of asthma and improve lung function. Fluticasone is the anti-inflammatory component of the combination, while salmeterol treats constriction of the airways.
Objective To explore the efficacy and safety of fluticasone propionate, cream and ointment, applied twice weekly in addition to maintenance treatment with emollients, in reducing the risk of relapse of chronic recurrent atopic dermatitis.. Design Randomised, double blind, parallel group study of 20 weeks duration.. Setting Dermatology outpatient clinics (6 countries, 39 centres).. Participants Adult (aged 12-65) patients with moderate to severe atopic dermatitis who were experiencing a flare.. Methods Participants applied fluticasone propionate (0.05% cream or 0.005% ointment; once or twice daily) regularly for four weeks to stabilise their condition. The patients whose disease was brought under control then continued into a 16 week maintenance phase, applying emollient on a daily basis with a bath oil as needed and either the same formulation of fluticasone propionate or its placebo base (emollient alone) twice weekly to the areas that were usually affected.. Main outcome measure Time to ...
Background: We previously showed that the long-acting beta agonist (LABA) salmeterol as inhalation powder or metered-dose inhaler improves lung-function parameters assessed by impulse oscillometry (IOS) in 2- to 5-year-old children with reversible-airway disease within 15 minutes. Objective: We studied 12- to 45-year-olds with mild persistent asthma in order to compare the onset and extent of peripheral airway effects following the first dose and after 4 weeks dosing with two inhaled corticosteroid (ICS)/LABA combinations: fluticasone propionate/salmeterol 115/21 and budesonide/formoterol 160/4.5. Methods: Thirty subjects with mild persistent asthma using only an as-needed short-acting beta-agonist (albuterol) who had at least a 40% change in integrated low-frequency reactance postalbuterol were selected and randomized to receive either fluticasone propionate/salmeterol or budesonide/formoterol (15 subjects each). We collected three to six IOS replicates at baseline, at 5, 20, 40, 60, 120, and 240
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Efficacy and safety of fluticasone furoate nasal spray, administered using a unique side-actuated device, were evaluated in patients ≥12 years of age with seasonal allergic rhinitis to determine the optimal dose. A randomized, double-blind, parallel-group, placebo-controlled, dose-ranging study was performed on 641 patients who received placebo (n = 128) or fluticasone furoate, 55 g (n = 127), 110 g (n = 127), 220 g (n = 129), or 440 g (n = 130), once daily for 2 weeks. Fluticasone furoate was significantly more effective than placebo for mean changes from baseline over the 2-week treatment period in daily reflective total nasal symptom score (primary end point; p < 0.001 each dose vs. placebo), morning predose instantaneous total nasal symptom score (p < 0.001 each dose versus placebo), daily reflective total ocular symptom score (p ≤ 0.013 each dose versus placebo), and morning predose instantaneous total ocular symptom score (p ≤ 0.019 for three highest doses versus ...
A Medline search (1966 to June 2009) was carried out to identify all placebo-controlled randomized trials, and observational reports for safety issues, with Dexamethasone, Budesonide (BUD), Fluticasone propionate (FP), Fluticasone furoate (FF), Flunisolide, Mometasone furoate (MF), Triamcinolone (TRIAM), and Beclomethasone dipropionate (BDP) as treatment for AR. Data on three efficacy (nasal symptoms, ocular symptoms, global assessment) and three safety outcomes (epistaxis, growth, systemic ocular effects) were extracted. Meta analyses were performed for each INS and outcome and results were categorised into scores by quartiles. Scores of the three efficacy and safety outcomes were summed up to create summation scores for efficacy (ES) and side effects (AES), respectively with a maximum of 9 points. The TIX was then defined as the ratio of ES and AES ...
Fast international; 24 jan 2013 recent news advair - efficient medication with no side effects. Fax or mail enrollment documents to the program with patient name and; 29 jul 2010 on march 2, 2006, fda approved new safety labeling and medication guides for patients for serevent diskus (salmeterol xinafoate) and advair; find information about common, infrequent and rare side effects of advair diskus inhl. Fax or mail enrollment documents to the program with patient name and; pharmacy price advair. Fda approves advair diskus 100 50 mcg for children four to eleven glaxosmithkline announced that the fda has approved the use of advair 100 50 in children; *asthma control test is a trademark of qualitymetric incorporated. Featuring active ingredients, dosages, related medications, and advair forums. Fertility advair for sale capsules price advair 250mcg 100mcg warnings black box. Find a comprehensive guide to possible side effects when taking advair diskus ( fluticasone propionate) for professionals, ...
Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive, hormonally-responsive, or hormone-receptor-positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers. Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy. US FDA approval was in October 2005. Exemestane is also indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has ...
BACKGROUND: Both long-acting beta(2)-agonists and inhaled corticosteroids have been recommended in guidelines for the treatment of chronic obstructive pulmonary disease (COPD). Their co-administration in a combined inhaler is intended to facilitate adherence to medication regimens and to improve efficacy. Three preparations are currently available: fluticasone propionate/salmeterol (FPS). budesonide/formoterol (BDF) and mometasone furoate/formoterol (MF/F).. OBJECTIVES: To assess the efficacy and safety of combined long-acting beta2-agonist and inhaled corticosteroid (LABA/ICS) preparations, as measured by clinical endpoints and pulmonary function testing, compared with inhaled corticosteroids (ICS) alone, in the treatment of adults with chronic obstructive pulmonary disease (COPD).. SEARCH METHODS: We searched the Cochrane Airways Group Specialised Register of trials, which is compiled from systematic searches of multiple literature databases. The search was conducted in June 2013. In addition, ...

Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.

0/Androstadienes; 0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/Nuclear Proteins; 0/Tumor Suppressor Protein p53; 0/Tumor ... Androstadienes / pharmacology. Ataxia Telangiectasia / metabolism, pathology, radiotherapy. Cell Cycle / physiology, radiation ...
more infohttp://www.biomedsearch.com/nih/Roles-DNA-dependent-protein-kinase/12065055.html

Airways hyperresponsiveness to different inhaled combination therapies in adolescent asthmatics.Airways hyperresponsiveness to different inhaled combination therapies in adolescent asthmatics.

Androstadienes / therapeutic use*. Asthma / drug therapy*. Asthma, Exercise-Induced / drug therapy. Bronchial Hyperreactivity ... 0/Androstadienes; 0/Bronchodilator Agents; 0/Drug Combinations; 0/Ethanolamines; 0/fluticasone, salmeterol drug combination; ...
more infohttp://www.biomedsearch.com/nih/Airways-hyperresponsiveness-to-different-inhaled/22519127.html

EEA1 exclusion reduces LBPA accumulation on latex beads | Open-iEEA1 exclusion reduces LBPA accumulation on latex beads | Open-i

Androstadienes/pharmacology. *Animals. *Anti-Bacterial Agents/pharmacology. *Antibodies/pharmacology. *Carrier Proteins/ ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2196432_0106049f7&req=4

Inhaled Corticosteroids Versus Long-Acting beta(2)-agonists for Chronic Obstructive Pulmonary Disease - PubMedInhaled Corticosteroids Versus Long-Acting beta(2)-agonists for Chronic Obstructive Pulmonary Disease - PubMed

Androstadienes / administration & dosage Actions. * Search in PubMed * Search in MeSH * Add to Search ...
more infohttps://pubmed.ncbi.nlm.nih.gov/22161409/

Tyrosine phosphorylation of signaling molecules upon  a | Open-iTyrosine phosphorylation of signaling molecules upon a | Open-i

Androstadienes/pharmacology. *Animals. *Binding Sites. *DNA, Complementary/genetics. *Enzyme Inhibitors/pharmacology. * ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2199152_JEM.971204f4&req=4

second malig neo pleura drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginesecond malig neo pleura drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine

MeSH-major] Androstadienes / therapeutic use. Antineoplastic Agents / therapeutic use. Breast Neoplasms / drug therapy. ... Chemical-registry-number] 0 / Androstadienes; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 ...
more infohttp://www.bmlsearch.com/?kwr=second+malig+neo+pleura+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1

Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kap by Ezra Aksoy, Wim Vanden Berghe et al."Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kap" by Ezra Aksoy, Wim Vanden Berghe et al.

Adaptor Proteins, Vesicular Transport; Androstadienes; Chromones; DNA-Binding Proteins; Dendritic Cells; Down-Regulation; ...
more infohttps://escholarship.umassmed.edu/infdis_pp/90/

G(alpha)11 signaling through ARF6 regulates F-actin mobilization and G by Avirup Bose, Andrew D. Cherniack et al."G(alpha)11 signaling through ARF6 regulates F-actin mobilization and G" by Avirup Bose, Andrew D. Cherniack et al.

1-Phosphatidylinositol 3-Kinase; ADP-Ribosylation Factors; Actins; Adenoviridae; Adipocytes; Androstadienes; Animals; ...
more infohttps://escholarship.umassmed.edu/oapubs/1433/

Statistics - Research Output
     - Penn StateStatistics - Research Output - Penn State

Landt, S. G., Marinov, G. K., Kundaje, A., Kheradpour, P., Pauli, F., Batzoglou, S., Bernstein, B. E., Bickel, P., Brown, J. B., Cayting, P., Chen, Y., DeSalvo, G., Epstein, C., Fisher-Aylor, K. I., Euskirchen, G., Gerstein, M., Gertz, J., Hartemink, A. J., Hoffman, M. M., Iyer, V. R. & 27 others, Jung, Y. L., Karmakar, S., Kellis, M., Kharchenko, P. V., Li, Q., Liu, T., Liu, X. S., Ma, L., Milosavljevic, A., Myers, R. M., Park, P. J., Pazin, M. J., Perry, M. D., Raha, D., Reddy, T. E., Rozowsky, J., Shoresh, N., Sidow, A., Slattery, M., Stamatoyannopoulos, J. A., Tolstorukov, M. Y., White, K. P., Xi, S., Farnham, P. J., Lieb, J. D., Wold, B. J. & Snyder, M., Sep 1 2012, In : Genome research. 22, 9, p. 1813-1831 19 p.. Research output: Contribution to journal › Review article ...
more infohttps://pennstate.pure.elsevier.com/en/organisations/statistics/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fsystematicreview&ordering=type&descending=false

Find Publications
             - Indiana University School of MedicineFind Publications - Indiana University School of Medicine

Kim, B. G., Li, C., Qiao, W., Mamura, M., Kasperczak, B., Anver, M., Wolfraim, L., Hong, S., Mushinski, E., Potter, M., Kim, S. J., Fu, X. Y., Deng, C. & Letterio, J. J., Jun 22 2006, In : Nature. 441, 7096, p. 1015-1019 5 p.. Research output: Contribution to journal › Article ...
more infohttps://indiana.pure.elsevier.com/en/publications/?format=&page=19&ordering=startDate&descending=false

Defining the roles of aromatase inhibitors in the adjuvant treatment of early-stage breast cancer. - The Christie Research...Defining the roles of aromatase inhibitors in the adjuvant treatment of early-stage breast cancer. - The Christie Research...

Androstadienes. -. dc.subject.mesh. Antineoplastic Combined Chemotherapy Protocols. -. dc.subject.mesh. Aromatase Inhibitors. - ...
more infohttp://christie.openrepository.com/christie/handle/10541/74920

Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis - Danish National Research...Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis - Danish National Research...

Administration, Inhalation; Aged; Androstadienes; Anti-Inflammatory Agents; Asthma; Bronchiectasis; Budesonide; Case-Control ...
more infohttp://www.forskningsdatabasen.dk/catalog/236062687

Gendoo - Relevant featuresGendoo - Relevant features

Androstadienes アンドロスタジエン Protein Kinases プロテインキナーゼ Phosphoproteins リン蛋白質 cdc42 GTP-Binding Protein cdc42蛋白質 ...
more infohttp://gendoo.dbcls.jp/cgi-bin/gendoo.cgi?geneid=3611&taxonomy=human

Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin...Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin...

Sirolimus; Androstadienes; Animals; Flavonoids; Enzyme Activation; DNA-Binding Proteins; Humans; Tyrosine; Enzyme Inhibitors; ...
more infohttps://air.unimi.it/handle/2434/197671

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Androstadienes - pharmacology , Signal Transduction - drug effects , Adenosine - analogs & derivatives , Myocardial Infarction ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=Author:Gharanei,%20M

DI-fusion Mature results of a randomized phase II multicenter study of...DI-fusion Mature results of a randomized phase II multicenter study of...

Androstadienes -- therapeutic use. Antineoplastic Agents, Hormonal -- adverse effects. Antineoplastic Agents, Hormonal -- ...
more infohttps://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/55258/Details

DeCS Ingl s+escopoDeCS Ingl s+escopo

D04.210.500.054.079.129 Androstadienes .. D04.210.500.054.079.129.453 Methandrostenolone .. D04.210.500.054.079.429 ...
more infohttp://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Norandrostenolone

5 Ways To Boost Your Natural Pheromones (Testosterone Hacks)5 Ways To 'Boost' Your Natural Pheromones (Testosterone Hacks)

It is the main precursor to pheromones, a lot of which are adrostenes, androstanes, and androstadienes. ...
more infohttps://houseofpheromones.com/natural-pheromones-boost-testosterone/

How to produce more male pheromonesHow to produce more male pheromones

It is the main precursor to pheromones, a lot of which are adrostenes, androstanes, and androstadienes..... Pheromones can also ...
more infohttp://friarsroast.com/new-south-wales/how-to-produce-more-male-pheromones.php

List of MeSH codes (D04) - WikipediaList of MeSH codes (D04) - Wikipedia

... androstadienes MeSH D04.808.054.079.129.453 --- methandrostenolone MeSH D04.808.054.079.129.782 --- testolactone MeSH D04.808. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D04)

NAVER Academic > Search...NAVER Academic > Search...

Aged, Albuterol, administration & dosage, adverse effects, analogs & derivatives, therapeutic use, Androstadienes, ...
more infohttps://academic.naver.com/search.naver?field=3&query=AMERICAN+JOURNAL+OF+RESPIRATORY+AND+CRITICAL+CARE+MEDICINE+175%EA%B6%8C+2%ED%98%B8

NAVER 학술정보 >...NAVER 학술정보 >...

Abiraterone Acetate, Androgens, blood, Androstadienes, administration & dosage, Double-Blind Method, Humans, Liquid-Liquid ...
more infohttps://academic.naver.com/search.naver?field=3&query=Journal+of+Clinical+Oncology+31%EA%B6%8C+22%ED%98%B8

Allergic rhinitis is a risk factor for traffic safety.  - PubMed - NCBIAllergic rhinitis is a risk factor for traffic safety. - PubMed - NCBI

Androstadienes/therapeutic use*. *Anti-Allergic Agents/therapeutic use. *Automobile Driving*. *Cetirizine/therapeutic use ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/?term=Allergic+rhinitis+is+a+risk+factor+for+traffic+safety

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