Androgen-Binding Protein
Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
Testis
Androgens
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Receptors, Androgen
Androgen-Insensitivity Syndrome
A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY.
Testosterone Congeners
Dihydrotestosterone
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Sex Hormone-Binding Globulin
A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
Prostate
Sertoli Cells
Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.
Salivary Proteins and Peptides
Sterol Regulatory Element Binding Protein 1
Sterol Regulatory Element Binding Protein 2
Lipogenesis
CCAAT-Enhancer-Binding Proteins
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Proteasome Endopeptidase Complex
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Leucine Zippers
DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
Receptors, Cytoplasmic and Nuclear
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Androgen Receptor Antagonists
Adenosine Triphosphatases
Epididymis
The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
Phodopus
Protein Inhibitors of Activated STAT
Histone Deacetylases
Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
Sin3 Histone Deacetylase and Corepressor Complex
SUMO-1 Protein
Histone Deacetylase Inhibitors
Research Design
Randomized Controlled Trials as Topic
Endometrium
Hu Paraneoplastic Encephalomyelitis Antigens
Decidua
The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.
Stromal Cells
Genitalia, Female
Androstadienes
Administration, Inhalation
Albuterol
Bronchodilator Agents
Budesonide
Nebulizers and Vaporizers
Betamethasone Valerate
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Effects of spinal cord injury on spermatogenesis and the expression of messenger ribonucleic acid for Sertoli cell proteins in rat Sertoli cell-enriched testes. (1/242)
The study was an examination of the effects of spinal cord injury (SCI) on spermatogenesis and Sertoli cell functions in adult rats with Sertoli cell-enriched (SCE) testes. The effects of SCI on the seminiferous epithelium were characterized by abnormalities in the remaining spermatogenic cells during the first month after SCI. Three days after SCI, serum testosterone levels were 80% lower, while serum FSH and LH levels were 25% and 50% higher, respectively, than those of sham control SCE rats. At this time, the levels of mRNA for androgen receptor (AR), FSH receptor (FSH-R), and androgen-binding protein (ABP) were normal whereas those for transferrin (Trf) had decreased by 40%. Thereafter, serum testosterone levels increased, but they remained lower than those of the sham control rats 28 days after SCI; and serum FSH and LH levels returned to normal. The levels of mRNA for AR, ABP, and Trf exhibited a biphasic increase 7 days after SCI and remained elevated 28 days after SCI. FSH-R mRNA levels were also elevated 90 days after SCI. Unexpectedly, active spermatogenesis, including qualitatively complete spermatogenesis, persisted in > 40% of the tubules 90 days after SCI. These results suggest that the stem cells and/or undifferentiated spermatogonia in SCE testes are less susceptible to the deleterious effects of SCI than the normal testes and that they were able to proliferate and differentiate after SCI. The presence of elevated levels of mRNA for Sertoli cell FSH-R and AR, as well as of that for the Sertoli cell proteins, in the SCE testes during the chronic stage of SCI suggests a modification of Sertoli cell physiology. Such changes in Sertoli cell functions may provide a beneficial environment for the proliferation of the stem cells and differentiation of postmeiotic cells, thus resulting in the persistence of spermatogenesis in these testes. (+info)Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor. (2/242)
The induction of immunity genes in Drosophila has been proposed to be dependent on Dorsal, Dif, and Relish, the NF-kappaB-related factors. Here we provide genetic evidence that Dif is required for the induction of only a subset of antimicrobial peptide genes. The results show that the presence of Dif without Dorsal is sufficient to mediate the induction of drosomycin and defensin. We also demonstrate that Dif is a downstream component of the Toll signaling pathway in activating the drosomycin expression. These results reveal that individual members of the NF-kappaB family in Drosophila have distinct roles in immunity and development. (+info)Characterization of lipid efflux particles generated by seminal phospholipid-binding proteins. (3/242)
We reported recently that the choline phospholipid-binding proteins (BSP-A1/-A2, BSP-A3 and BSP-30-kDa) of bovine seminal plasma (BSP) stimulate cholesterol and choline phospholipid efflux from fibroblasts. In this study, we characterized the lipid efflux particles generated by BSP proteins. The density gradient ultracentrifugation of the efflux medium from radiolabeled fibroblasts incubated with BSP proteins showed a single peak of [3H]cholesterol between density (d) 1.12 and 1.14 g/ml, which is in the range of high-density lipoproteins. Size-exclusion chromatographic and immunoblot analysis revealed that the efflux particles have a large size equal to or bigger than very low-density lipoproteins and contained BSP proteins. Lipid analysis of density gradient and gel filtration fractions from efflux medium of simultaneously labeled fibroblasts ([3H]cholesterol and [3H]choline) incubated with BSP proteins showed that the efflux particles were homogeneous and composed of cholesterol and choline phospholipids. The lipid particles contained BSP proteins, cholesterol and choline phospholipids in molar ratio of 0.05:1.21:1, respectively. Agarose gel electrophoresis showed that the BSP-generated lipid particles had a gamma migration pattern which is slower than low-density lipoproteins. The sonication of cholesterol and BSP proteins followed by gel filtration chromatographic analysis indicated no direct binding of cholesterol to BSP proteins. These results taken together indicate that BSP proteins induce a concomitant cholesterol and choline phospholipid efflux and generate large protein-lipid particles. (+info)Selective activation of the probasin androgen-responsive region by steroid hormones. (4/242)
Glucocorticoid and androgen receptors have been shown to function through the same palindromic glucocorticoid response element (GRE) and yet have differential effects on gene transcription. In this study, we examined the functional and structural relationship of the androgen and glucocorticoid receptors with the androgen responsive region (ARR) of the probasin (PB) gene containing two androgen receptor binding sites, ARBS-1 and ARBS-2. Transfection studies indicated that one copy of each cis-acting DNA element was essential for maximal androgen-induced chloramphenicol acetyltransferase (CAT) activity and that androgen selectivity was maintained when multiple copies of the minimal wild type (wt) androgen responsive region containing both ARBS-1 and ARBS-2 (-244 to -96) were subcloned in front of the thymidine kinase promoter. Furthermore, replacing the androgen response region with 1, 2 or 3 copies of either ARBS-1 or ARBS-2 restored less than 4% of the biological activity seen with the wt PB ARR. Multiple copies of either ARBS-1 or ARBS-2 did not result in glucocorticoid-induced CAT gene activity. By comparison, 1 or 2 copies of the tyrosine aminotransferase (TAT) GRE, as well as the mouse mammary tumour virus GRE, were strong inducers of CAT activity in response to both androgen and glucocorticoid treatment. In addition, band shift assays demonstrated that although the synthetic glucocorticoid receptor, GR-DNA binding domain (GR-DBD), and the synthetic androgen receptor, AR2, could interact with the TAT GRE (dissociation constants Kd of 63.9 and 14.1 respectively), only AR2 but not GR-DBD binding could be detected on ARBS-1 and ARBS-2. Our findings provide further evidence that androgen-induced regulation of gene transcription can occur through androgen-specific DNA binding sites that are distinct from the common GRE. (+info)The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts. (5/242)
CV787, a novel highly prostate-specific replication-competent adenovirus with improved efficacy, was constructed. CV787 contains the prostate-specific rat probasin promoter, driving the adenovirus type 5 (Ad5) E1A gene, and the human prostate-specific enhancer/promoter, driving the E1B gene. To improve efficacy, we constructed CV787 such that it also contains the entire Ad5 E3 region. CV787 replicates in prostate-specific antigen (PSA)+ cells as well as wild-type adenovirus, but in PSA- cells, CV787 replicates 10(4)-10(5) times less efficiently. CV787 destroys PSA+ prostate cancer cells 10,000 times more efficiently than PSA- cells. Incorporation of the Ad5 E3 region significantly improves the target cell killing ability or efficacy of CV787. In nu/nu mice carrying s.c. LNCaP xenografts, a single i.v. tail vein injection of CV787 eliminates 300-mm3 tumors within 4 weeks. CV787 could be a powerful therapeutic for human metastatic prostate cancer. (+info)Reduced nucleotide variability at an androgen-binding protein locus (Abpa) in house mice: evidence for positive natural selection. (6/242)
Previous work has shown that the gene for the alpha subunit of androgen-binding protein, Abpa, may be involved in premating isolation between different subspecies of the house mouse, Mus musculus. We investigated patterns of DNA sequence variation at Abpa within and between species of mice to test several predictions of a model of neutral molecular evolution. Intraspecific variation among 10 Mus musculus domesticus alleles was compared with divergence between M. m. domesticus and M. caroli for Abpa and two X-linked genes, Glra2 and Amg. No variation was observed at Abpa within M. m. domesticus. The ratio of polymorphism to divergence was significantly lower at Abpa than at Glra2 and Amg, despite the fact that all three genes experience similar rates of recombination. Interspecific comparisons among M. m. domesticus, Mus musculus musculus, Mus musculus castaneus, Mus spretus, Mus spicilegus, and Mus caroli revealed that the ratio of nonsynonymous substitutions to synonymous substitutions on a per-site basis (Ka/Ks) was generally greater than one. The combined observations of no variation at Abpa within M. m: domesticus and uniformly high Ka/Ks values between species suggest that positive directional selection has acted recently at this locus. (+info)Heterotopic endochondrial ossification with mixed tumor formation in C3(1)/Tag transgenic mice is associated with elevated TGF-beta1 and BMP-2 expression. (7/242)
Transgenic mice which express the simian virus 40 large T-antigen (Tag) under the regulatory control of the hormone responsive rat C3(1) gene develop unusual lesions of heterotopic bone growth associated with mixed tumor formation arising from eccrine sweat glands found only in the foot pads of mice, ischiocavernosus muscle adjacent to bulbourethral glands and occasionally the salivary and mammary glands. These lesions are very similar to mixed tumors arising in several types of human cancers. Based upon electron microscopic examination and immunocytochemical analyses of cellular differentiation markers, the mixed proliferative lesions in this transgenic mouse model begin with the Tag-induced proliferation of epithelial and myoepithelial cells. The proliferation of these two types of cells results in hyperplasia and adenomatous transformation of the epithelial component, whereas the proliferating myoepithelial cells undergo metaplasia to form chondrocytes which deposit extracellular matrix, including collagen fibers. Cartilage develops focally between areas of epithelial proliferation and subsequently ossifies through a process of endochondrial bone formation. The metaplasia of myoepithelial cells to chondrocytes appears to require the inductive interaction of factors produced by the closely associated proliferating epithelial cells, including members of the TGF-beta superfamily. We demonstrate that TGF-beta1 protein accumulates in the extracellular matrix of the lesions, whereas RNA in situ hybridization reveals that BMP-2, another strong inducer of heterotopic bone formation, is overexpressed by the proliferating epithelial cells during the development of ectopic bone. The formation of sarcomatous tumors within the mixed tumors appears to be androgen-dependent and more frequent in mice lacking a normal allele of p53. This process of cartilage and bone induction may mimic epithelial-mesenchymal interactions which occur during embryonic bone formation. These transgenic mice may provide new insights into the processes of ectopic endochondrial bone formation associated with mixed tumor formation and serve as a useful model for human heterotopic bone disease. (+info)Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces. (8/242)
Phosphatidylcholine transfer protein (Pc-tp) is a highly specific carrier of phosphatidylcholine (PC) without known function. Proposed functions include the supply of PC required for secretion into bile or lung air space (surfactant) and the facilitation of enzymatic reactions involving PC synthesis or breakdown. To test these functions, we generated knock-out mice unable to make Pc-tp. Remarkably, these mice are normal and have no defect in any of the postulated Pc-tp functions analyzed. The lipid content and composition of the bile, as well as lung surfactant secretion and composition, of Pc-tp (-/-) mice, is normal. The lack of a Pc-tp contribution to biliary lipid secretion is in agreement with our finding that Pc-tp is down-regulated in adult mouse liver: whereas Pc-tp is abundant in the liver of mouse pups, Pc-tp levels decrease > 10-fold around 2 wk after birth, when bile formation starts. In adult mice, Pc-tp levels are high only in epididymis, testis, kidney, and bone marrow-derived mast cells. Absence of Pc-tp in bone marrow-derived mast cells does not affect their lipid composition or PC synthesis and degradation. We discuss how PC might reach the canalicular membrane of the hepatocyte for secretion into the bile, if not by Pc-tp. (+info)
Androgen-binding protein | definition of Androgen-binding protein by Medical dictionary
Androgen-binding protein elisa and antibody
Actions of insulin and vitamin A on Sertoli cells | Biochemical Journal
Production of an antibody to mouse salivary androgen binding protein (ABP) and its use in identifying a prostate protein...
Androgen binding proteins in human prostatic hyperplasis. Methodological aspects]. - Semantic Scholar
The phosphatidylcholine-transfer protein catalyzed import of phosphatidylcholine into isolated rat liver mitochondria
sertoli cells QuickView - Correlation Engine
Sertoli Cells
5.1.1 Testis
5.1.1 Testis
CL:0000216 - resource browser
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RELA
Aarnisalo P, Palvimo JJ, Jänne OA (Mar 1998). "CREB-binding protein in androgen receptor-mediated signaling". Proceedings of ... "Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with ... Parry GC, Mackman N (Dec 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB- ... Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T (Apr 1997). "CREB-binding protein/p300 are transcriptional ...
ALDH1A1
Pereira F, Rosenmann E, Nylen E, Kaufman M, Pinsky L, Wrogemann K (March 1991). "The 56 kDa androgen binding protein is an ... This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the ...
Robert Vigersky
Androgen Binding Proteins of Testis, Epididymis and Plasma in Man and Monkey. Vigersky RA, Andersen AE, Thompson RH, Loriaux DL ...
Hypothalamic-pituitary-gonadal axis
FSH stimulates sustentacular cells to release androgen-binding protein, which promotes testosterone binding. LH binds to the ... Depending on which hormone and receptor are unable to bind different effects occur but all alter the HPG axis. For example, the ... Examples of such necessary liver proteins are vitellogenin and choriogenin. The HPA, HPG, and HPT axes are three pathways in ... GnRH travels down the anterior portion of the pituitary via the hypophyseal portal system and binds to receptors on the ...
PA2G4
ErbB3 binding protein 1) mediated repression of androgen receptor signalling". British Journal of Cancer. 92 (1): 140-6. doi: ... Proliferation-associated protein 2G4 (PA2G4) also known as ErbB3-binding protein 1 (EBP1) is a protein that in humans is ... This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ... Zhang Y, Hamburger AW (June 2004). "Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter ...
TMF1
2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609-18 ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene. TMF1 has been shown to interact with ... Hsiao, P W; Chang C (Aug 1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated ...
PRPF6
The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. PRPF6 ... Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. ... Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. ... Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene. The protein encoded by this gene appears ...
SYTL1
Johnson JL, Ellis BA, Noack D, Seabra MC, Catz SD (November 2005). "The Rab27a-binding protein, JFC1, regulates androgen- ... Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links ... Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links ... Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene. Model organisms have been used in the ...
Sertoli cell
androgen binding protein (also called testosterone binding globulin) - increases testosterone concentration in the seminiferous ... dichlorodiphenyldichloroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells". ... transferrin - a blood plasma protein for iron ion delivery Testicular ceruloplasmin - a ceruloplasmin-like protein which is ... Sertoli cells bind to spermatogonial cells via N-cadherins and galactosyltransferase (via carbohydrate residues). During the ...
Seminiferous tubule
They secrete androgen-binding protein, a binding protein which increases the concentration of testosterone inside the ...
SPINLW1
2005). "Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif". ... Eppin is a protein that in humans is encoded by the SPINLW1 gene. This gene encodes an epididymal protease inhibitor, which ... locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein ...
BMS-564,929
Crystal Structure Of The Rat Androgen Receptor Ligand Binding Domain Complex With Bms-564929 at Protein Data Bank. ... Gao W, Dalton JT (March 2007). "Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs ... Selective androgen receptor modulators may also be used by athletes to assist in training and increase physical stamina and ... This means there is a clinical need for selective androgen receptor modulators, which produce anabolic effects in some tissues ...
DEFB118
Yenugu S, Hamil KG, Radhakrishnan Y, French FS, Hall SH (Jul 2004). "The androgen-regulated epididymal sperm-binding protein, ... "Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and ... Beta-defensin 118 is a protein that in humans is encoded by the DEFB118 gene. GRCh38: Ensembl release 89: ENSG00000131068 - ...
TMEPAI
... an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate ... Transmembrane prostate androgen-induced protein is a protein that in humans is encoded by the PMEPA1 gene. TMEPAI has been ... an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate ... "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ...
Metabotropic glutamate receptor 4
... "p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing ... Enz R (Mar 2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Letters ... Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM6, GRM7 and GRM8 it ... Gaughan L, Logan IR, Cook S, Neal DE, Robson CN (Jul 2002). "Tip60 and histone deacetylase 1 regulate androgen receptor ...
Spermatogenesis
... which is achieved via the binding of testosterone by androgen binding protein present in the seminiferous tubules. Testosterone ... FSH stimulates both the production of androgen binding protein (ABP) by Sertoli cells, and the formation of the blood-testis ... The protein FMRP binds to meiotic chromosomes and regulates the dynamics of the DDR machinery during spermatogenesis. FMRP ... blood-testis barrier Secrete substances initiating meiosis Secrete supporting testicular fluid Secrete androgen-binding protein ...
Follicle-stimulating hormone
FSH enhances the production of androgen-binding protein by the Sertoli cells of the testes by binding to FSH receptors on their ... In males, FSH induces Sertoli cells to secrete androgen-binding proteins (ABPs), regulated by inhibin's negative feedback ... FSH binding is thought to upregulate neovascularization via at least two mechanisms - one in the VEGF pathway, and the other ... Hypothalamic control of pituitary FSH-regulatory proteins and their relationship to changes in FSH synthesis and secretion". ...
Khalid Zaffar Masoodi
Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor". PLOS ONE. 10 (7): e0128495. doi:10.1371/ ... i. Androgen deprivation therapy (ADT) is the standard treatment for patients with prostate-specific antigen progression after ... "Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl) ... "Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based ...
TMF1 - ويكيبيديا
2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609-18 ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... regulation of proteasomal protein catabolic process. • male gonad development. • regulation of transcription, DNA-templated. • ... Hsiao PW، Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated ...
CREB1
"The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at ... This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein ... Zhang Q, Vo N, Goodman RH (Jul 2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and ... CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This ...
PRSS8 - ويكيبيديا
"Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG". The ... separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as ... "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression" ...
Hormonal contraception
Additionally, estrogen in the pills stimulates the liver to produce more of a protein that binds to androgens and reduces their ... Birth control pills are often prescribed to reverse the effects of excessive androgen levels, and decrease ovarian hormone ... scientists had isolated and determined the structure of the steroid hormones and found that high doses of androgens, estrogens ... as they prevent ovulation and decrease androgen production by the ovaries. ...
PRSS8
"Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG". The ... Prostasin is a protein that in humans is encoded by the PRSS8 gene. This gene encodes a trypsinogen, which is a member of the ... The protein is implicated in epithelial sodium channel regulation and may help regulate a variety of tissue functions that ... an androgen-regulated serine protease with prostate-restricted expression". Proceedings of the National Academy of Sciences of ...
SNAI2
"Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG". The ... The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin ... Zinc finger protein SNAI2 is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes the ... This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. It regulates differentiation and ...
USP10
The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and ... Soncini C, Berdo I, Draetta G (2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ... Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation ... "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. 20 (29 ...
Forkhead box protein O1
FOXO1 has been shown to interact with: androgen receptor, estrogen receptor alpha, CREB-binding protein, and tuberous sclerosis ... "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in ... Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by ... protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein ...
Sustentacular cell
... androgen-binding protein and Mullerian-inhibiting factor.[citation needed] The organ of Corti in the inner ear and taste buds ... "Odorant-Binding Proteins and Xenobiotic Metabolizing Enzymes: Implications in Olfactory Perireceptor Events: Odorant-Binding ... Proteins and Metabolizing Enzymes". The Anatomical Record. 296 (9): 1333-1345. doi:10.1002/ar.22735. PMID 23907783. Zhuo, ...
PARK7
... a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 ... Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. ... It belongs to the peptidase C56 family of proteins. The protein structures of human protein DJ-1, Escherichia coli chaperone ... a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 ...
CYP2C18
RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene ... This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located ... Cytochrome P450 2C18 is a protein that in humans is encoded by the CYP2C18 gene. This gene encodes a member of the cytochrome ... The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of ...
EFCAB6
... a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 ... EF-hand calcium-binding domain-containing protein 6 is a protein that in humans is encoded by the EFCAB6 gene. EFCAB6 has been ... "Entrez Gene: FLJ23588 CAP-binding protein complex interacting protein 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple ... shown to interact with PARK7 and Androgen receptor. GRCh38: Ensembl release 89: ENSG00000186976 - Ensembl, May 2017 GRCm38: ...
HOXD8
RNA polymerase II regulatory region sequence-specific DNA binding. • DNA binding. • sequence-specific DNA binding. • ... Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[5][6][7] ... 1989). "Complementary homeo protein gradients in developing limb buds". Genes Dev. 3 (5): 641-50. doi:10.1101/gad.3.5.641. PMID ... HOXD8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Muscle atrophy
... specificity is gained by coupling targeted proteins to an "E3 ubiquitin ligase". Each E3 ubiquitin ligase binds to a particular ... selective androgen receptor modulators) are being investigated with promising results. They would have fewer side-effects, ... The protein balance at time of dormancy is also maintained by lower levels of protein breakdown during the winter time. At ... Furthermore, 1 gram of nitrogen is roughly equivalent to 6 gram of protein, and 1 gram of protein is roughly equivalent to 4 ...
Acne
... influenced by androgens), excessive deposition of the protein keratin leading to comedo formation, colonization of the follicle ... C. acnes' ability to bind and activate a class of immune system receptors known as toll-like receptors (TLRs), especially TLR2 ... protein.[45] PPARα increases the activity of activator protein 1 (AP-1) and NF-κB, thereby leading to the recruitment of ... Both androgens and IGF-1 seem to be essential for acne to occur, as acne does not develop in individuals with complete androgen ...
Androgen
Androgens bind to and activate androgen receptors (ARs) to mediate most of their biological effects. ... "G protein-coupled receptors: extranuclear mediators for the non-genomic actions of steroids". Int J Mol Sci. 15 (9): 15412-25 ... Soon after they differentiate, Leydig cells begin to produce androgens.. Androgen effects[edit]. The androgens function as ... This article is about androgens as natural hormones. For androgens as medications, see Anabolic steroid and Androgen ...
Coffin-Lowry syndrome
Deficiencies of intracellular signaling peptides and proteins. GTP-binding protein regulators. GTPase-activating protein. * ... Androgen insensitivity syndrome/Spinal and bulbar muscular atrophy. *KAL1 Kallmann syndrome. *X-linked adrenal hypoplasia ... Mutations in the RPS6KA3 disturb the function of the protein, but it is unclear how a lack of this protein causes the signs and ... The RPS6KA3 gene makes a protein that is involved with signaling within cells. Researchers believe that this protein helps ...
Antiandrogen
AR NTD antagonists bind covalently to the NTD of the AR and prevent protein-protein interactions subsequent to activation that ... Androgen receptor antagonistsEdit. Androgens and anti-. androgens at the AR[82][83]. Compound. RBA (%). ... Androgen receptor antagonists: drugs that bind directly to and block the AR.[57][58] These drugs include the steroidal ... R 1881 binding to the prostatic androgen receptor and [3H]5 alpha-dihydrotestosterone and [3H]cortisol binding to plasma ...
Hyperimmunoglobulin E syndrome
DNA-binding domains. 2.1. *(Intracellular receptor): Thyroid hormone resistance. *Androgen insensitivity syndrome *PAIS ... Genetic disorder, protein biosynthesis: Transcription factor/coregulator deficiencies. (1) Basic domains. 1.2. *Feingold ...
多囊卵巢綜合症 - 维基百科,自由的百
Kelly CJ, Stenton SR, Lashen H. Insulin-like growth factor binding protein-1 in PCOS: a systematic review and meta-analysis. ... Androgen Excess PCOS Society. 2006年,Androgen Excess PCOS Society提出了一套嚴謹診斷標準[15]:. *具有雄性激素過剩症狀 ... The Free androgen index (FAI) of the ratio of testosterone to sex hormone-binding globulin (SHBG) is high[15][61]and is meant ... It has previously been suggested that the excessive androgen production in PCOS could be caused by a decreased
Myc
Blackwood EM, Eisenman RN (1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex ... podfamilija 3 (Steroidni hormon (Androgen, Estrogen (α, β), Glukokortikoid, Mineralokortikoid, Progesteron), Estrogen-vezani (α ... "Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant". Genes Dev. ... 1988). "A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is ...
Proteasome
... sterol-regulated element-binding proteins and androgen receptors are all controlled by the UPS and thus involved in the ... The protein degradation processEdit. Ribbon diagram of ubiquitin, the highly conserved protein that serves as a molecular tag ... After a protein has been ubiquitinated, it is recognized by the 19S regulatory particle in an ATP-dependent binding step.[15][ ... The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein.[1] The ...
Male reproductive system
19 July 1990). "A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif ... This is caused by the androgens produced and secreted by the testes. Androgen induced development causes the elongation and ... Some individuals are male who have the XX male syndrome and androgen insensitivity syndrome. This occurs when one X chromosome ... The spermatic cord, formed from spermatic artery, vein and nerve bound together with connective tissue passes into the testis ...
Estrogen insensitivity syndrome
... in the helix H5 of the ligand-binding domain (LBD) of the ERα protein.[6] This is a critical residue that is completely ... Androgen insensitivity syndrome[edit]. Main article: Androgen insensitivity syndrome. In contrast to EIS, androgen ... Sex hormone-binding globulin, corticosteroid-binding globulin, thyroxine-binding globulin, prolactin, and triglycerides, which ... EIS is analogous to androgen insensitivity syndrome (AIS), a condition in which the androgen receptor (AR) is defective and ...
Y chromosome
So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[49] ... See also: Androgen insensitivity syndrome and Intersex. Most therian mammals have only one pair of sex chromosomes in each cell ... at least 72 of which code for proteins.[5] Traits that are inherited via the Y chromosome are called Y-linked traits, or ... with between 45 and 73 of these protein-coding. All single-copy Y-linked genes are hemizygous (present on only one chromosome) ...
Peptide
... often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecule (DNA, RNA, etc.), or to ... "Hormone (androgen deprivation) therapy for prostate cancer". cancer.org. Retrieved 3 October 2013.. ... Peptide fragments refer to fragments of proteins that are used to identify or quantify the source protein.[13] Often these are ... For example, synthetic peptides can be used as probes to see where protein-peptide interactions occur- see the page on Protein ...
异性恋 - 维基百科,自由的百科全书
... androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding ... Protein Sci. May 2006, 15 (5): 987-99. PMC 2242507. PMID 16641486. doi:10.1110/ps.051905906.. ... 研究者已對腦部男性化的神經生物機轉進行了不少研究。5α還原酶會把雌二醇和睾
Breast development
... insulin-like growth factor binding protein-3 and epidermal growth factor on human breast epithelial cells in primary culture". ... In complete androgen insensitivity syndrome, a condition in which the AR is defective and insensitive to androgens, there is ... "A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene ... Calcitriol, the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR), has, like the androgens, been ...
FOXA3
sequence-specific DNA binding. • DNA binding. • transcription factor binding. • protein domain specific binding. • RNA ... HNF-3G is a member of the forkheadclass of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional ... 2003). "Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte ... transcription factor activity, sequence-specific DNA binding. • transcription regulatory region DNA binding. • ...
Chemotherapy
Now it is clear that there is often a range of protein targets that the drug can bind. An example target for targeted therapy ... primarily estrogens for breast cancer and androgens for prostate cancer) is known as hormonal therapy, while the inhibition of ... Mutations in genes that produce drug target proteins, such as tubulin, can occur which prevent the drugs from binding to the ... including proteins, RNA and DNA. This ability to bind covalently to DNA via their alkyl group is the primary cause for their ...
ಟೆಂಪ್ಲೇಟು:Central nervous system navs - ವಿಕಿಪೀಡಿಯ
Template:DNA and protein biosynthesis navs(edit talk links history)- Genetics ({{Protein biosynthesis navs}}, R) ...
Diglyceride
Protein kinase C activation[edit]. PIP2 cleavage to IP3 and DAG initiates intracellular calcium release and PKC activation. ... Binding of DAG to the C1 domain of Munc13 increases the fusion competence of synaptic vesicles resulting in potentiated release ... Steroids: Sex steroids: Androgens (AR). *Estrogens (ER). *Progestogens (PR); Corticosteroids: Glucocorticoids (GR) ... a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol ...
RAR-srodni orfan receptor beta
Protein kodiran ovim genom je član NR1 potfamilije nuklearnih hormonskih receptora. To je DNA-vezujući protein koji se može ... podfamilija 3 (Steroidni hormon (Androgen, Estrogen (α, β), Glukokortikoid, Mineralokortikoid, Progesteron), Estrogen-vezani (α ... 2001). "X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.". Embo J. 20 ( ... 2000). "Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor ...
Histone acetyltransferase
... and it is the last protein to bind in the complex.. Histones tend to be positively charged proteins with N-terminal tails that ... and the androgen receptor (AR).[18] PCAF has also been observed to acetylate c-MYC, GATA-2, retinoblastoma (Rb), Ku70, and E1A ... structural proteins, polyamines, and proteins involved in nuclear import.[3] Acetylation of these proteins can alter their ... Many MYST proteins also contain a cysteine-rich, zinc-binding domain within the HAT region in addition to an N-terminal ...
Sterol regulatory element-binding protein
Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ... Sterol regulatory element-binding transcription factor 1. X-ray crystallography of Sterol Regulatory Element Binding Protein 1A ... SCAP, in turn, can bind reversibly with another ER-resident membrane protein, INSIG. In the presence of sterols, which bind to ... proteins. However, in contrast to E-box-binding HLH proteins, an arginine residue is replaced with tyrosine making them capable ...
Diabetes insipidus
When released, ADH binds to V2 G-protein coupled receptors within the distal convoluted tubules, increasing cyclic AMP, which ... Androgen receptor (Androgen insensitivity syndrome). *general: Hypogonadism (Delayed puberty). *Hypergonadism *Precocious ... it acts on proteins called aquaporins and more specifically aquaporin 2 in the following cascade. ... couples with protein kinase A, stimulating translocation of the aquaporin 2 channel stored in the cytoplasm of the distal ...
Plastic pollution
It does this by binding to globulins that normally bind to sex hormones such as androgens and estrogens, leading to the ... This then decreases the level of thyroid hormone binding proteins that bind to triiodothyronine. By affecting the thyroid ...
X-inactivation
The XIC also contains binding sites for both known and unknown regulatory proteins.[32] ... Besides, measuring the methylation (inactivation) status of the polymorphic human androgen receptor (HUMARA) located on X- ... implications for methyl-CpG binding proteins". BMC Biology. 2: 21. doi:10.1186/1741-7007-2-21. PMC 521681 . PMID 15377381.. ... It is hypothesized[by whom?] that there is an autosomally-encoded 'blocking factor' which binds to the X chromosome and ...
Diethylstilbestrol
... and hence is not bound to these proteins in the circulation.[78] The plasma protein binding of DES is greater than 95%.[2] ... It suppresses gonadal androgen production and hence circulating androgen levels due to its antigonadotropic effects; it ... interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma". J. Clin. ... G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators". Pharmacol. Rev. 67 (3): 505-40. doi:10.1124/pr. ...
Farnesoid X receptor
bile acid binding. • protein binding. • ligand-dependent nuclear receptor binding. • transcription factor activity, RNA ... RNA polymerase II distal enhancer sequence-specific DNA binding. • sequence-specific DNA binding. • DNA binding. • ... metal ion binding. • retinoid X receptor binding. • steroid hormone receptor activity. • transcriptional activator activity, ... chenodeoxycholic acid binding. • transcription regulatory region sequence-specific DNA binding. • RNA polymerase II regulatory ...
Norethisterone
The plasma protein binding of norethisterone is 97%.[4] It is bound 61% bound to albumin and 36% bound to SHBG.[4] ... Norethisterone binds to SHBG with less affinity than endogenous androgens and oestrogens [...]. ... Protein binding. 97%:[4]. Albumin: 61%;[4]. SHBG: 36%[4]. Metabolism. Mainly CYP3A4 (liver);[1] also 5α-/5β-reductase, 3α-/3β- ... Norethisterone binds to the ERs, the ERα and the ERβ, with 0.07% and 0.01% of the relative binding affinity of estradiol.[48] ...
Inositol trisphosphate receptor
5-trisphosphate-binding protein P400". Nature. 342 (6245): 32-8. Bibcode:1989Natur.342...32F. doi:10.1038/342032a0. PMID ... Steroids: Sex steroids: Androgens (AR). *Estrogens (ER). *Progestogens (PR); Corticosteroids: Glucocorticoids (GR) ... The initial sequencing was reported as an unknown protein enriched in the cerebellum called P400.[5] The large size of this ... December 2002). "Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand". Nature. 420 ( ...
Androgen-binding protein - Wikipedia
Androgen-Binding+Protein at the US National Library of Medicine Medical Subject Headings (MeSH) Ensembl Gene ref Protein ref. ... Androgen-binding protein (ABP) is a glycoprotein (beta-globulin) produced by the Sertoli cells in the seminiferous tubules of ... "Extracellular androgen binding proteins". Annual Review of Physiology. 43: 189-98. doi:10.1146/annurev.ph.43.030181.001201. ... "Secretion and role of androgen-binding proteins in the testis and epididymis". Journal of Reproduction and Fertility. ...
Androgen binding protein as a biochemical marker of formation of the blood-testis barrier. - PubMed - NCBI
Androgen binding protein as a biochemical marker of formation of the blood-testis barrier.. Tindall DJ, Vitale R, Means AR. ... Androgen binding protein (ABP) was measured during postnatal development in normal and irradiated rats to determine whether ... 2.8 pmol/mg protein) than in normal testis (0.5 pmol/mg protein). In the SCE testis neither blood-testis barrier development ...
Recent progress in the development of protein-protein interaction inhibitors targeting androgen receptor-coactivator binding in...
Androgen receptor; Coactivator binding inhibition; Coregulator recruitment; Peptidomimetics; Prostate cancer; Protein-protein ... Recent progress in the development of protein-protein interaction inhibitors targeting androgen receptor-coactivator binding in ... While frontline androgen-deprivation therapies targeting either the production or action of androgens usually yield favorable ... Structural analyses of the AR have identified key surfaces involved in protein-protein interaction with coregulators that have ...
Production of an antibody to mouse salivary androgen binding protein (ABP) and its use in identifying a prostate protein...
... because of its ability to bind androgen, we designated androgen binding protein (ABP) and its structural gene, Androgen bindi ... We previously demonstrated polymorphism of a mouse salivary protein which, ... because of its ability to bind androgen, we designated androgen binding protein (ABP) and its structural gene, Androgen binding ... androgen binding proteins mouse salivary proteins mouse prostate Western transfer This work was supported in part by intramural ...
Fluoride Action Network | Does fluoride affect serum testosterone and androgen binding protein with age-specificity? A...
Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding...
... phenomenon in androgen-responsive prostate tumor lines and involves activation of the sterol regulatory element-binding protein ... we demonstrate that coordinated stimulation of lipogenic gene expression by androgens is a common ... of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway ... androgens induce a major increase in the expression of sterol regulatory element-binding protein cleavage-activating protein ( ...
Castration-Induced Increases in Insulin-Like Growth Factor-Binding Protein 2 Promotes Proliferation of Androgen-independent...
Castration-Induced Increases in Insulin-Like Growth Factor-Binding Protein 2 Promotes Proliferation of Androgen-independent ... Castration-Induced Increases in Insulin-Like Growth Factor-Binding Protein 2 Promotes Proliferation of Androgen-independent ... Castration-Induced Increases in Insulin-Like Growth Factor-Binding Protein 2 Promotes Proliferation of Androgen-independent ... Castration-Induced Increases in Insulin-Like Growth Factor-Binding Protein 2 Promotes Proliferation of Androgen-independent ...
Tat-Binding Protein-1 (TBP-1), an ATPase of 19S Regulatory Particles of the 26S Proteasome, Enhances Androgen Receptor Function...
Tat-Binding Protein-1 (TBP-1), an ATPase of 19S Regulatory Particles of the 26S Proteasome, Enhances Androgen Receptor Function ... Using yeast two-hybrid screening, we previously identified Tat-binding protein-1 (TBP-1), an adenosine triphosphatase of 19S ... The 26S proteasome, which degrades ubiquitinated proteins, appears to contribute to the cyclical loading of androgen receptor ( ... TBP-1 directly bound TBPIP through the amino-terminal domain possessing the leucine zipper structure. AR is physically ...
Androgen-binding protein elisa and antibody
Recombinant Protein and Androgen-binding protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody ... Androgen-binding protein homolog. Androgen-binding protein homolog ELISA Kit. Androgen-binding protein homolog Recombinant. ... Protein Family Androgen-binding protein. LOG IN MY ACCOUNT CART CONTENTS CHECKOUT ... Below are the list of possible Androgen-binding protein products. If you cannot find the target and/or product is not available ...
DJBP: A Novel DJ-1-Binding Protein, Negatively Regulates the Androgen Receptor by Recruiting Histone Deacetylase Complex, and...
... androgen receptor-interacting protein 3) as a DJ-1-binding protein (3). PIASxα/ARIP3 belongs to the PIAS family of proteins, ... androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability ... After a ligand binds to the AR, the AR is translocated into the nucleus and binds to the androgen-responsive element, ARE, on ... DJBP: A Novel DJ-1-Binding Protein, Negatively Regulates the Androgen Receptor by Recruiting Histone Deacetylase Complex, and ...
Androgen binding proteins in human prostatic hyperplasis. Methodological aspects]. - Semantic Scholar
Androgen binding proteins in human prostatic hyperplasis. Methodological aspects]. by J Y Dubé et al. ... Androgen binding proteins in human prostatic hyperplasis. Methodological aspects].. *. J Y Dubé, Réjean Tremblay, L F Coulonval ... article{Dub1975AndrogenBP, title={[Androgen binding proteins in human prostatic hyperplasis. Methodological aspects].}, author ...
Androgen-binding protein | definition of Androgen-binding protein by Medical dictionary
What is Androgen-binding protein? Meaning of Androgen-binding protein medical term. What does Androgen-binding protein mean? ... Looking for online definition of Androgen-binding protein in the Medical Dictionary? Androgen-binding protein explanation free ... androgen binding protein. (redirected from Androgen-binding protein). Also found in: Acronyms, Wikipedia. an·dro·gen bind·ing ... medical-dictionary.thefreedictionary.com/Androgen-binding+protein,androgen binding protein,/a,. *Facebook ...
Androgen-Binding Protein | Profiles RNS
"Androgen-Binding Protein" by people in this website by year, and whether "Androgen-Binding Protein" was a major or minor topic ... Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of ... "Androgen-Binding Protein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Androgen-Binding Protein*Androgen-Binding Protein. *Protein, Androgen-Binding. *Androgen Binding Protein ...
Androgen binding protein synonyms, Androgen binding protein antonyms - FreeThesaurus.com
Antonyms for Androgen binding protein. 1 synonym for androgen: androgenic hormone. What are synonyms for Androgen binding ... Synonyms for Androgen binding protein in Free Thesaurus. ... Androgen Binding Protein Beta. *Androgen Binding Protein Gamma ... Androgen binding protein synonyms, Androgen binding protein antonyms - FreeThesaurus.com https://www.freethesaurus.com/Androgen ... androgen. (redirected from Androgen binding protein). Also found in: Dictionary, Medical, Encyclopedia, Wikipedia. #vtZoom,.vt- ...
The production of androgen binding protein by Sertoli Cells.<...
The production of androgen binding protein by Sertoli Cells. Current topics in molecular endocrinology. 1974;1:167-175. https ... The production of androgen binding protein by Sertoli Cells. / Tindall, D. J.; Schrader, W. T.; Means, A. R. ... Tindall, D. J. ; Schrader, W. T. ; Means, A. R. / The production of androgen binding protein by Sertoli Cells. In: Current ... Tindall, D. J., Schrader, W. T., & Means, A. R. (1974). The production of androgen binding protein by Sertoli Cells. Current ...
Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP
... Academic Article ... Androgen receptor (AR)-mediated transcription is modulated by interaction with coregulatory proteins. We demonstrate that the ... Repression of AR-mediated transcription is achieved, in part, by URI binding and regulation of androgen receptor trapped clone ... While Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role ...
Characterization of an androgen binding protein (ABP) in rat testis and epididymis<...
Characterization of an androgen binding protein (ABP) in rat testis and epididymis. / Ritzén, E. Martin; Dobbins, M. Catherine ... N2 - An androgen binding protein (ABP) was demonstrated in the 105,000 g supernatant of rat testis homogenate after charcoal ... AB - An androgen binding protein (ABP) was demonstrated in the 105,000 g supernatant of rat testis homogenate after charcoal ... An androgen binding protein (ABP) was demonstrated in the 105,000 g supernatant of rat testis homogenate after charcoal ...
Measurement of ovine plasma androgens by a competitive protein binding method : a thesis presented in partial fulfilment of the...
Measurement of ovine plasma androgens by a competitive protein binding method : a thesis presented in partial fulfilment of the ... A method has been developed for measuring plasma testosterone in sheep using competitive protein binding (CPB) techniques. The ... and final determination of plasma testosterone by the CPB technique using salt precipitation of the protein bound fraction. The ...
Salivary androgen-binding protein variation in Mus and other rodents<...
Karn, R. C. ; Dlouhy, S. R. / Salivary androgen-binding protein variation in Mus and other rodents. In: Journal of Heredity. ... Karn, R. C., & Dlouhy, S. R. (1991). Salivary androgen-binding protein variation in Mus and other rodents. Journal of Heredity ... Salivary androgen-binding protein variation in Mus and other rodents. / Karn, R. C.; Dlouhy, S. R. ... Karn, RC & Dlouhy, SR 1991, Salivary androgen-binding protein variation in Mus and other rodents, Journal of Heredity, vol. ...
Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression<...
Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression. / Shiota, Masaki ... Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression. In: Endocrine- ... Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression. Endocrine- ... title = "Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression", ...
Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals<...
Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals. BMC Evolutionary ... Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals. / Laukaitis, ... Laukaitis, CM, Heger, A, Blakley, TD, Munclinger, P, Ponting, CP & Karn, RC 2008, Rapid bursts of androgen-binding protein ( ... Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals. ...
The Poly(C)-binding protein-1 regulates expression of the androgen receptor - WRAP: Warwick Research Archive Portal
Here we show that HESCs express three RNA-binding proteins, Hu antigen R and the poly(C)-binding proteins PCBP1 and PCBP2, that ... 2010) The Poly(C)-binding protein-1 regulates expression of the androgen receptor. Endocrinology, Vol.151 (No.8). pp. 3954-3964 ... The Poly(C)-binding protein-1 regulates expression of the androgen receptor ... Decidualization profoundly down-regulated AR protein levels with no discernible effect on either AR mRNA or protein stability, ...
Compound Report Card
Testis-specific androgen-binding protein Homo sapiens 1.000 CHEMBL3746 11-beta-hydroxysteroid dehydrogenase 2 Homo sapiens ... Niemann-Pick C1-like protein 1 Homo sapiens 0.995 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Homo sapiens ... The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1473. A 1uM and 10 uM cut ... Testis-specific androgen-binding protein Homo sapiens 1.000 CHEMBL3072 Androgen Receptor Rattus norvegicus 0.999 ...
Compound Report Card
Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound...
Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ... Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ... Thus, we asked whether differential presentation of protein-protein interaction surfaces on the androgen receptor (AR), a ... over 150 proteins/polypeptides whose ability to interact with AR is influenced in a differential manner by ligand binding. The ...
Syndrome of androgen insensitivity in man: absence of 5α dihydrotestosterone binding protein in skin fibroblasts<...
No appreciable DHT binding was detectable in fibroblasts from androgen insensitive patients. Deficiency of DHT binding protein ... No appreciable DHT binding was detectable in fibroblasts from androgen insensitive patients. Deficiency of DHT binding protein ... No appreciable DHT binding was detectable in fibroblasts from androgen insensitive patients. Deficiency of DHT binding protein ... No appreciable DHT binding was detectable in fibroblasts from androgen insensitive patients. Deficiency of DHT binding protein ...
The Implications of Knocking Out Two Major Salivary Androgen-Binding Protein Genes for Mouse Viability, Fecundity and the...
Photoaffinity labeling of extracellular and intracellular androgen binding proteins | Acta physiol. pharmacol. latinoam;36(1):...
Index: LILACS (Americas) Main subject: Testosterone / Affinity Labels / Receptors, Androgen / Androgen-Binding Protein Limits: ... Index: LILACS (Americas) Main subject: Testosterone / Affinity Labels / Receptors, Androgen / Androgen-Binding Protein Limits: ... Androgen-Binding Protein/metabolism , Receptors, Androgen/metabolism , Testosterone/pharmacology , Chromatography, Gel , Hot ... Photoaffinity labeling of extracellular and intracellular androgen binding proteins Photoaffinity labeling of extracellular and ...
Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by...
Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by ... Two of these carrier proteins, testicular androgen-binding protein (ABP) and plasma sex hormone-binding globulin (SHBG), are ... Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by ... a process that is thought to be modulated by extracellular androgen carrier proteins. ...
Definition of androgen receptor positive - NCI Dictionary of Cancer Terms - National Cancer Institute
Cancer cells that are androgen receptor positive may need androgens to grow. ... Describes cells that have a protein that binds to androgens (male hormones). ... Describes cells that have a protein that binds to androgens (male hormones). Cancer cells that are androgen receptor positive ... These cells may stop growing or die when they are treated with substances that block the binding and actions of androgen ...
ReceptorsHormone-bindingDihydrotestosteroneHormonesEstrogensGeneGenesAbstractSHBGCarrier ProteinsDeprivation TherapyTumorCytoplasmicEffects of androgensProgesteroneRegulatesAffinityCellsTestosterone bindsTranscription factorEpididymisRegulationRegulateSecretionLNCaPSynthesisRestored androgen receptorGenomicMRNATranscriptionalLigandPathwaysSeminiferous tubulesCytoplasmAndrogenicProstate cancer cellCastration-resistant prostate cancerProduce androgensInteractionReceptor tyrosinBiosynthesisTesticular feminizationDimer bindsNuclear receptorMolecularSteroidsPhosphorylationSerumProstaticProliferationStimulateTransactivationRecombinant ProteinsMaleAntibodiesSalivary
Receptors33
- Independently, TBP-1-interacting protein (TBPIP) was also identified as a coactivator of several nuclear receptors, including AR. (scialert.net)
- Although PIAS family proteins have been shown to play roles in SUMO-1 conjugation ( 6 -11 ) and in the regulations of STAT ( 12 , 13 ), nuclear receptors ( 4 , 5 , 14 -17 ), and K channels ( 18 ), the contribution of DJ-1 to such functions is not clear. (aacrjournals.org)
- Moreover, gene families, such as those containing olfactory or vomeronasal receptors, immunoglobulin domain-containing proteins, or cytochromes P450 that are expanded in one lineage are often expanded in another. (beds.ac.uk)
- In addition to this transcriptional genomic action, androgens and other steroid hormones like progesterone and estrogen can exert rapid nongenomic effects that are not mediated through nuclear receptors, but rather initiated at the plasma membrane, presumably through surface receptors ( 3 , 4 ). (aacrjournals.org)
- Like progesterone (PR) and estrogen (ER) receptors, AR can interact with the intracellular tyrosine kinase c-Src to activate the mitogen-activated protein kinase (MAPK) pathway ( 5 , 6 ). (aacrjournals.org)
- Bicalutamide binds to proteins called androgen receptors, which are found in some prostate cancer cells. (cancer.gov)
- Complementary DNAs (cDNAs) encoding androgen receptors were obtained from human testis and rat ventral prostate cDNA libraries. (sciencemag.org)
- The amino acid sequence deduced from the nucleotide sequences of the cDNAs indicated the presence of a cysteine-rich DNA-binding domain that is highly conserved in all steroid receptors. (sciencemag.org)
- In some cell types testosterone interacts directly with androgen receptors while in others testosterone is converted by 5-alpha-reductase to dihydrotestosterone, an even more potent agonist for androgen receptor activation. (thefullwiki.org)
- The primary mechanism of action for androgen receptors is direct regulation of gene transcription . (thefullwiki.org)
- Androgen receptors interact with other proteins in the nucleus resulting in up or down regulation of specific gene transcription . (thefullwiki.org)
- [ 11 ] Thus, changes in levels of specific proteins in cells is one way that androgen receptors control cell behavior. (thefullwiki.org)
- More recently, androgen receptors have been shown to have a second mode of action. (thefullwiki.org)
- As has been also found for other steroid hormone receptors such as estrogen receptors , androgen receptors can have actions that are independent of their interactions with DNA. (thefullwiki.org)
- [ 6 ] [ 12 ] Androgen receptors interact with certain signal transduction proteins in the cytoplasm. (thefullwiki.org)
- Androgen binding to cytoplasmic androgen receptors can cause rapid changes in cell function independent of changes in gene transcription, such as changes in ion transport . (thefullwiki.org)
- Regulation of signal transduction pathways by cytoplasmic androgen receptors can indirectly lead to changes in gene transcription, for example, by leading to phosphorylation of other transcription factors. (thefullwiki.org)
- Another connection is that luteinizing hormone and follicle stimulating hormone carry out their duties by triggering the actions of second messengers once they bind to cell receptors in the gonads. (wisegeek.com)
- For this to happen, these hormones have to bind to androgen receptors, proteins located mostly in the cytoplasm of prostate cells. (news-medical.net)
- This is what we believe the molecules we identified are doing to androgen receptors in a prostate tumor,' said Verjovski-Almeida, who is also a professor in the University of São Paulo's Chemistry Institute (IQ-USP). (news-medical.net)
- The next step was to find out whether these lncRNAs interacted with androgen receptors. (news-medical.net)
- We detected more than 600 lncRNAs bound to androgen receptors in prostate tumors. (news-medical.net)
- Androgen receptors are known to be capable of binding to more than 10,000 different genome sites upon migrating to cell nuclei. (news-medical.net)
- [1] GnRH travels down the anterior portion of the pituitary via the hypophyseal portal system and binds to receptors on the secretory cells of the adenohypophysis . (wikia.com)
- Winstrol binds well with androgen receptors. (namhaihotel.com)
- It does not bind well with estrogen receptors and helps avoid water retention. (namhaihotel.com)
- As with other nuclear receptors, AR has three distinct domains: an N-terminal transactivation domain (NTD), a central DNA binding domain, and a C-terminal ligand binding domain (LBD). (pubmedcentralcanada.ca)
- The compound in HMG-Xtreme binds to muscle androgen receptors causing increased protein synthesis rates. (anabolicminds.com)
- This means that HMG-Xtreme only binds to 17β-estradiol receptors in certain tissues such as mammary (breast). (anabolicminds.com)
- Some chemicals do this by binding to receptors, such as the estrogen and androgen receptors. (fda.gov)
- The testosterone binds to androgen receptors and causes increased protein synthesis. (energymanagertraining.com)
- When taken into the cell, it can bind to the cytoplasmic estrogen receptors, and activate genes related to estrogen, tricking cells into thinking they are in an environment containing estrogen when they are not. (igem.org)
- this is a small sequence of DNA that the receptors can specifically bind once they are dimerized (3). (igem.org)
Hormone-binding7
- Two of these carrier proteins, testicular androgen-binding protein (ABP) and plasma sex hormone-binding globulin (SHBG), are encoded by the same gene, but differ in glycosylation and possibly amino acid sequence. (duke.edu)
- Similarly, among the sex steroids, testosterone binds more tightly to sex hormone-binding globulin than do other androgens or estrogens. (britannica.com)
- Sex hormone-binding globulin (SHBG) is the blood transport protein for testosterone and estradiol. (labcorp.com)
- Most of the circulating testosterone is bound to carrier proteins (sex hormone-binding globulin [SHBG], and albumin). (cdc.gov)
- Sex hormone-binding globulin (SHBG) is the blood transport protein for androgens and estrogens. (cdc.gov)
- Sex hormone-binding globulin is homodimeric, meaning it has two identical peptide chains making up its structure. (wikipedia.org)
- SHBG (Sex Hormone-binding Globulin), also known as ABP (Androgen-binding Protein), is a variably glycosylated, secreted, non-disulfide-linked homodimer. (rndsystems.com)
Dihydrotestosterone9
- Androgen-binding protein (ABP) is a glycoprotein (beta-globulin) produced by the Sertoli cells in the seminiferous tubules of the testis that binds specifically to testosterone (T), dihydrotestosterone (DHT), and 17-beta-estradiol. (wikipedia.org)
- It contained saturable high-affinity sites which exhibited binding specificity for dihydrotestosterone (6) and testosterone when measured by polyacrylamide gel electrophoresis or by competitive binding using charcoal adsorption. (elsevier.com)
- A method was developed for measuring specific dihydrotestosterone (DHT) binding in cultured human skin fibroblasts. (utmb.edu)
- SHBG has a high binding affinity to dihydrotestosterone (DHT), medium affinity to testosterone and estradiol, and only a low affinity to estrone, DHEA, androstenedione, and estriol. (labcorp.com)
- The androgen receptor ( AR ), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor [ 1 ] which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone . (thefullwiki.org)
- [ 7 ] Testosterone appears to be the primary androgen receptor activating hormone in the Wolffian duct while dihydrotestosterone is the main androgenic hormone in the urogenital sinus , urogenital tubercle, and hair follicles . (thefullwiki.org)
- Androgens, particularly dihydrotestosterone, bind to the AR with high affinity and stimulate the transcription of a cascade of androgen-responsive genes. (aacrjournals.org)
- In most cases of prostate cancer, tumor cell growth is stimulated by the action of male hormones, or androgens, such as testosterone and dihydrotestosterone (DHT). (news-medical.net)
- They're also going to be secreting a hormone called DHT, dihydrotestosterone, a much more potent androgen than testosterone. (coursera.org)
Hormones21
- Because ABP binds to T and DHT, these hormones are made less lipophilic and become concentrated within the luminal fluid of the seminiferous tubules. (wikipedia.org)
- What hormones and proteins do Sertoli cells produce? (brainscape.com)
- Describes cells that have a protein that binds to androgens (male hormones). (cancer.gov)
- These cells may stop growing or die when they are treated with substances that block the binding and actions of androgen hormones. (cancer.gov)
- In serum, many hormones exist both as free, unbound hormone and as hormone bound to a serum carrier or transport protein . (britannica.com)
- These proteins, which are produced by the liver, bind to specific hormones in the serum. (britannica.com)
- In serum, protein-bound hormones are in equilibrium with a much smaller concentration of free, unbound hormones. (britannica.com)
- The affinity (attraction) of hormones for binding proteins is not constant. (britannica.com)
- Levels of SHBG are under the positive control of estrogens and thyroid hormones, and are suppressed by androgens. (labcorp.com)
- These proteins bind to androgens (male hormones) and may cause cancer cells to grow. (cancer.gov)
- This data will allow for population estimates of the selected steroid hormones and related binding protein that can be used to assist in disease diagnosis, treatment, and prevention of disease such as, Polycystic Ovary Syndrome (PCOS), androgen deficiency, cancer, and hormone imbalances in children. (cdc.gov)
- People with too little sex hormones can be short during puberty but end up taller as adults as in androgen insensitivity syndrome or estrogen insensitivity syndrome . (thefullwiki.org)
- These proteins then bind to testosterone and other hormones to generate sperm. (wisegeek.com)
- Other steroid hormones such as progesterone , cortisol , and other corticosteroids are bound by transcortin . (wikipedia.org)
- A brief survey will be made of the characteristics of the physicochemical methods that have been used to study the binding of steroid hormones by plasma protein. (annals.org)
- Androgens and estrogens are hormones. (drugs.com)
- Male and female sex hormones bind SHBG with equal affinity. (rndsystems.com)
- Androgens are hormones required for normal function of the prostate. (moffitt.org)
- BIRMINGHAM, Ala. - Androgens, commonly known as male hormones, stimulate prostate cancer cells to grow. (brightsurf.com)
- The androgen receptor, or AR, is a cellular protein in prostate tissues that is activated by binding androgen hormones like testosterone. (brightsurf.com)
- More recently, he has investigated the influence of environmental hormones on reproductive function and the mechanisms by which these effects are mediated through steroid receptor and/or steroid-binding protein pathways. (vanderbilt.edu)
Estrogens4
- [7] In women, SHBG serves to limit exposure to both androgens and estrogens . (wikipedia.org)
- [7] Low SHBG levels in women have been associated with hyperandrogenism and endometrial cancer due to heightened exposure to androgens and estrogens, respectively. (wikipedia.org)
- 1. Albumin is the principal binding protein for the less polar steroids, (androgens, estrogens, and progesterone). (annals.org)
- Androgens and estrogens may also be used for other conditions as determined by your doctor. (drugs.com)
Gene43
- We previously demonstrated polymorphism of a mouse salivary protein which, because of its ability to bind androgen, we designated androgen binding protein (ABP) and its structural gene, Androgen binding protein (Abp) . (springer.com)
- Tcp (Testosterone controlled protein): The structural gene for the mouse salivary protein under the influence of Ssp (Sex-limited saliva pattern). (springer.com)
- Multiple gene action determining a mouse salivary protein phenotype: Identification of the structural gene for androgen binding protein (Abp). (springer.com)
- Seminal vesicle protein in rats: A gene in the fourth linkage group determining electrophoretic variants. (springer.com)
- Using two independent prostate cancer cell lines (LNCaP and MDA-PCa-2a), we demonstrate that coordinated stimulation of lipogenic gene expression by androgens is a common phenomenon in androgen-responsive prostate tumor lines and involves activation of the sterol regulatory element-binding protein (SREBP) pathway. (nih.gov)
- Both time course studies and overexpression experiments showing that increasing levels of SCAP enhance the production of mature SREBP and stimulate lipogenic gene expression support the contention that SCAP plays a pivotal role in the lipogenic effects of androgens in tumor cells. (nih.gov)
- In the chromatin immunoprecipitation assay, TBP-1 was transiently recruited to the proximal androgen response element of the prostate-specific antigen gene promoter in a ligand-dependent manner in LNCaP cells. (scialert.net)
- The draft mouse (Mus musculus) genome sequence revealed an unexpected proliferation of gene duplicates encoding a family of secretoglobin proteins including the androgen-binding protein (ABP) α, β and γ subunits. (elsevier.com)
- Karn, Robert C. / Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals . (elsevier.com)
- The levels of AR are tightly controlled in androgen-responsive cells in which it plays a central role in the regulation of target gene expression. (warwick.ac.uk)
- To investigate ABP-SHBG gene expression in fetal rat liver, we analyzed RNA transcripts and expressed protein. (duke.edu)
- The other cDNA represented a fused transcript of the ABP-SHBG gene (exons 1-5) and the histidine decarboxylase (HDC) gene, encoding a Mr 98,000 precursor protein. (duke.edu)
- Moreover, a Mr 93,000 immunoreactive protein was transiently expressed in fetal liver during the time of ABP and HDC gene expression. (duke.edu)
- A putative trans-splicing which involves HDC and SHBG gene regions produces a fusion protein expressed in fetal liver. (uniprot.org)
- p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
- p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
- is a gene on the Y chromosome that codes for the 'sex-determining region Y' protein. (studystack.com)
- a protein coded by the KISS1 gene that is important in initiating the secretion of gonadotropin-releasing hormone in puberty. (studystack.com)
- Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene. (wikipedia.org)
- The protein product of this gene, FMRP (fragile X mental retardation protein), is thought to be involved in the translational regulation of mRNAs important for learning and memory. (biochemj.org)
- Decreased SHBG concentrations are often seen with hypothyroidism, polycystic ovarian syndrome (PCOS), obesity, hirsutism, elevated androgen levels, alopecia, acromegaly and some polymorphisms on the SHBG gene. (cdc.gov)
- URI1 (URI1, Prefoldin Like Chaperone) is a Protein Coding gene. (genecards.org)
- Gene Ontology (GO) annotations related to this gene include chromatin binding and protein phosphatase inhibitor activity . (genecards.org)
- The androgen insensitivity syndrome , formerly known as testicular feminization, is caused by a mutation of the Androgen Receptor gene located on the X chromosome (locus:Xq11-Xq12). (thefullwiki.org)
- SBMA is caused by mutation in the gene for the androgen receptor (AR). (mda.org)
- When the mutant gene is translated, the resulting protein contains too many glutamine amino acids. (mda.org)
- Many MDA-supported projects are focused on understanding how the downstream effects of mutations in the androgen receptor gene affect cells, and developing methods to overcome or compensate for these effects. (mda.org)
- The human androgen receptor gene contains polymorphic CAG and GGC repeats in exon 1. (aacrjournals.org)
- Our results do not support the hypothesis that a small number of CAG or GGC repeats in the androgen receptor gene increases a man's risk of prostate cancer. (aacrjournals.org)
- Here, we use a ranking score and benign prostate transcriptomes to identify a non-coding polymorphic regulatory element at 7p14.3 that associates with DNA repair and hormone-regulated transcript levels and with an early recurrent prostate cancer-specific somatic mutation in the Speckle-Type POZ protein (SPOP) gene. (nature.com)
- When hormone and receptor bind, they migrate to the cell nucleus, where they either activate or inhibit a number of genes to create a gene expression pattern that favors tumor proliferation. (news-medical.net)
- These are molecules that bind to the complex formed by androgen and its receptor in the cell nucleus, possibly for the purpose of fine regulation of the gene activation and inhibition process,' Verjovski-Almeida said. (news-medical.net)
- These data provide a kinetic and mechanistic basis for regulation of gene expression by androgens and antiandrogens in living cells. (pubmedcentralcanada.ca)
- Therefore, the importance of these intramolecular and possible additional intermolecular (between two AR proteins) interactions for the function of AR with respect to its target gene in vivo has not been directly assessed. (pubmedcentralcanada.ca)
- A genome-wide analysis showed that protein-coding gene neighbors to ARA-lincRNAs had a significantly higher androgen-induced change in expression than protein-coding genes neighboring lincRNAs not associated to AR. (frontiersin.org)
- This work highlights the possible involvement of hundreds of lincRNAs working in synergy with the AR on the genome-wide androgen-induced gene regulatory program in prostate cells. (frontiersin.org)
- The AR transcription factor mediates the effect of androgen hormone and modulates the gene transcriptional program in prostate cells. (frontiersin.org)
- binds to genomic DNA target sites and promotes a highly regulated androgen-dependent gene activation program. (frontiersin.org)
- There is ample evidence that long non-coding RNAs (lncRNAs) can interact with a number of proteins and regulate gene expression ( Khalil and Rinn, 2011 ). (frontiersin.org)
- Importantly, the AMPA-induced apoptosis was potentiated with the addition of MAA, which was due to downregulation of the anti-apoptotic gene baculoviral inhibitor of apoptosis protein repeat containing 2 (BIRC2), leading to activation of caspases 7 and 3. (mdpi.com)
- The aim of this study was to evaluate genome-wide DNA methylation and gene expression in the livers of newborn rats exposed to maternal protein restriction. (plos.org)
- The data showed that maternal protein restriction is associated with widespread differential gene expression and DNA methylation across the genome, and that folic acid is able to reset both molecular signatures. (plos.org)
- Altobelli G, Bogdarina IG, Stupka E, Clark AJL, Langley-Evans S (2013) Genome-Wide Methylation and Gene Expression Changes in Newborn Rats following Maternal Protein Restriction and Reversal by Folic Acid. (plos.org)
Genes12
- While Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes. (scripps.edu)
- The Androgen-binding protein (Abp) genes in the house mouse genome have undergone extensive duplications that produced 64 Abp paralogs. (arizona.edu)
- Androgens and their nuclear receptor regulate genes necessary for development of the male phenotype, a process that is thought to be modulated by extracellular androgen carrier proteins. (duke.edu)
- In response to androgen, cytoplasmic AR rapidly translocates to the nucleus and interacts with sequence-specific androgen response elements (ARE) in the transcriptional regulatory regions of target genes ( 1 , 2 ). (aacrjournals.org)
- [ 6 ] Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype . (thefullwiki.org)
- One of the known target genes of androgen receptor activation is insulin-like growth factor I ( IGF-1 ). (thefullwiki.org)
- One example is serum response factor , a protein which activates several genes that cause muscle growth. (thefullwiki.org)
- In LNCaP cells, a human prostate epithelial cell line, HX109 repressed AR-mediated cell proliferation and the induction of androgen receptor (AR) target genes at the transcriptional level without affecting the translocation or expression of AR. (mdpi.com)
- Androgen receptor (AR) regulates genes expression in multiple tissues and diseases, by targeting binding elements in promoters and distant enhancers. (nature.com)
- The other 98%, formerly dismissed as 'junk DNA', produces different types of RNA termed noncoding because they are generally not translated into proteins but modulate the expression of neighboring genes or the action of proteins produced by those genes. (news-medical.net)
- To find relevant epigenetic signatures enriched at the ARA-lincRNAs' transcription start sites (TSSs) we used a machine learning approach and identified that the ARA-lincRNA genomic loci in LNCaP cells are significantly enriched with epigenetic marks that are characteristic of in cis enhancer RNA regulators, and that the H3K27ac mark of active enhancers is conspicuously enriched at the TSS of ARA-lincRNAs adjacent to androgen-activated protein-coding genes. (frontiersin.org)
- Fork-head box protein A1 (FOXA1) is a ''pioneer factor' ' that is known to bind to the androgen receptor (AR) and regulate the transcription of AR-specific genes. (psu.edu)
Abstract2
- abstract = "The androgen receptor (AR) is well known to play a central role in the pathogenesis of prostate cancer (PCa). (elsevier.com)
- ABSTRACT: BACKGROUND: Inducible high-level expression is favoured for recombinant protein production in Pichia pastoris. (biomedsearch.com)
SHBG19
- Se describe un método de marcación por fotoafinidad de la SHBG sérica humana y de conejo en un precipitado de sulfato de amonio utilizando delta6- testosterona 3H como ligando . (bvsalud.org)
- La cromatografía en columna de Sephadex G-200 mostró un único pico radioactivo unido covalentemente con el volumen de elución de la SHBG. (bvsalud.org)
- Este preparado es útil para ser utilizado en estudios de metabolización de la SHBG in vivo. (bvsalud.org)
- SHBG binds reversibly to sexual steroids. (labcorp.com)
- Albumin, which exists in far higher concentrations than SHBG, also binds to sexual steroids−although with a clearly lower binding affinity (eg, about 100 times lower for testosterone). (labcorp.com)
- In serum, SHBG mainly takes over the transportation of steroids and the reduction/regulation of the effect of androgen. (labcorp.com)
- 7,8 Decreased SHBG serum levels are associated with conditions in which elevated androgen levels are present or in which the effect of androgen on its target organs is excessive. (labcorp.com)
- Albumin, which exists in far higher concentrations than SHBG, also binds sexual steroids - although with a clearly lower binding affinity (e.g. about 100 times lower for testosterone). (cdc.gov)
- Measurement of SHBG can be an important indicator of an excessive/chronic androgenic action where androgen levels are normal, but where clinical symptoms would seem to indicate androgen in excess. (cdc.gov)
- SHBG is a useful supplementary parameter in the determination of androgen where a relatively high concentration of free androgen (e.g. testosterone) is suspected (Pugeat, et al. (cdc.gov)
- [6] DHT binds to SHBG with about 5 times the affinity of testosterone and about 20 times the affinity of estradiol. (wikipedia.org)
- [7] Dehydroepiandrosterone (DHEA) is weakly bound to SHBG, but dehydroepiandrosterone sulfate is not bound to SHBG. (wikipedia.org)
- [6] Androstenedione is not bound to SHBG either, and is instead bound solely to albumin. (wikipedia.org)
- [8] Estrone sulfate and estriol are also poorly bound by SHBG. (wikipedia.org)
- [9] Less than 1% of progesterone is bound to SHBG. (wikipedia.org)
- [7] The high SHBG levels during pregnancy may serve to protect the mother from exposure to fetal androgens that escape metabolism by the placenta . (wikipedia.org)
- [11] Testes-produced SHBG is called androgen-binding protein . (wikipedia.org)
- The mechanism of activating the promoter for SHBG in the liver involves hepatocyte nuclear factor 4 alpha ( HNF4A ) binding to a DR1 like cis element which then stimulate production. (wikipedia.org)
- If HNF4A level is low then COUP-TF binds to the first site and turns off production of SHBG. (wikipedia.org)
Carrier Proteins1
- Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. (ouhsc.edu)
Deprivation Therapy5
- Because most metastatic specimens were from men who had undergone androgen ablation, we examined the primary tumors from patients who have undergone hormone deprivation therapy and found that a significant fraction of these specimens showed nuclear localization of ErbB3. (aacrjournals.org)
- What is androgen deprivation therapy? (moffitt.org)
- Androgen deprivation therapy, or ADT, is a treatment that reduces androgen production. (moffitt.org)
- 1] Since the seminal discovery of the hormone dependence of prostate cancer by Huggins and colleagues more than 7 decades ago, androgen deprivation therapy (ADT) has been the main treatment strategy for metastatic prostate cancer. (cancernetwork.com)
- This standard treatment is known as androgen deprivation therapy. (brightsurf.com)
Tumor7
- In this article, we characterize changes in IGFBP-2 in the LNCaP tumor model after androgen withdrawal and evaluate its functional significance in AI progression using gain-of-function and loss-of-function analyses. (aacrjournals.org)
- Increased IGFBP-2 levels after androgen ablation may represent an adaptive response that helps potentiate IGF-I-mediated survival and mitogenesis and promote androgen-independent tumor growth. (aacrjournals.org)
- Because prostate cancer is an androgen-sensitive tumor, androgen withdrawal, for example, via castration, is used in some therapeutic regimens for patients with advanced prostate cancer. (aacrjournals.org)
- OGX-427 treatment of mice bearing LNCaP xenografts transfected with an androgen-regulated, probasin-luciferase reporter construct resulted in decreased bioluminescence and serum PSA levels as pharmacodynamic readouts of AR activity, as well as AR, Hsp27, and Hsp90 protein levels in LNCaP tumor tissue. (aacrjournals.org)
- We thus assessed the effect of androgens and the bone microenvironment on the nuclear translocation of ErbB-3 by using xenograft tumor models generated from bone-derived prostate cancer cell lines, MDA PCa 2b, and PC-3. (aacrjournals.org)
- Our findings suggest that the cellular localization of ErbB-3 in prostate cancer cells is a dynamic process that can be influenced by the tumor microenvironment and androgen status. (aacrjournals.org)
- FOXA1 Promotes Tumor Progression in Prostate Cancer via the Insulin-Like Growth Factor Binding Protein 3 Pathway. (psu.edu)
Cytoplasmic4
- Development of increased cytoplasmic binding of androgen in the submandibular gland of the mouse with testicular feminization. (springer.com)
- Initial studies indicate that about one half of the measured binding is nuclear and the rest cytoplasmic. (utmb.edu)
- In the absence of ligand, AR is predominantly cytoplasmic, maintained in an inactive but highly responsive state by a large dynamic heterocomplex composed of heat-shock proteins (Hsp), co-chaperones, and tetratricopeptide repeat (TPR)-containing proteins. (aacrjournals.org)
- When BPA is present in the environment, it diffuses through the cell membrane and binds to free cytoplasmic estrogen receptor (1). (igem.org)
Effects of androgens3
- and 4) that cotransfection with dominant-negative forms of SREBPs abolishes the effects of androgens. (nih.gov)
- The classic model of androgen-regulated AR transcriptional activity has not fully defined the many diverse effects of androgens on prostate cancer cell survival and growth. (aacrjournals.org)
- The effects of androgens are mediated by the androgen receptor (AR), which is a ligand-dependent transcription factor that belongs to the nuclear receptor superfamily. (pubmedcentralcanada.ca)
Progesterone3
- The AR protein shares highly structural similarities in the DBD and LBD with other steroid nuclear receptor family members, such as glucocorticoids receptor (GR), mineral corticoid receptor (MR), and progesterone receptor (PR). (omicsonline.org)
- [ 2 ] The androgen receptor is most closely related to the progesterone receptor , and progestins in higher dosages can block the androgen receptor. (thefullwiki.org)
- After the menopause, when progesterone synthesis has ceased altogether, excess weight may continue increasing risk through elevated plasma levels of androgen precursors, increasing estrogen levels through the aromatization of the androgens in adipose tissue. (aacrjournals.org)
Regulates1
- This binding protein can be found in the circulation where it regulates hormone access to target tissues. (rndsystems.com)
Affinity4
- For instance, lysine 221 acetylation facilitates RELA dissociation from IκBα and enhances its DNA-binding affinity. (wikipedia.org)
- The protein bound androgens specifically and with high affinity. (sciencemag.org)
- Most of these variants reside in non-coding regulatory regions and may affect the transcription factors (TFs)-binding affinity 4 . (nature.com)
- A major element of the EDKB program has been the development of computer-based predictive models to predict affinity for binding of compounds to the estrogen and androgen nuclear receptor proteins. (fda.gov)
Cells35
- The androgen receptor (AR) is a key regulator for the growth, differentiation and survival of prostate cancer cells. (nih.gov)
- Coregulator recruitment is a crucial regulatory step in AR signaling and the direct blockade of coactivator binding to AR offers the opportunity to develop therapeutic agents that would remain effective in prostate cancer cells resistant to conventional endocrine therapies. (nih.gov)
- IGFBP-2 mRNA and protein levels increase 2-3-fold after androgen withdrawal in LNCaP cells in vitro in LNCaP tumors during AI progression in vivo . (aacrjournals.org)
- Furthermore, a co-immunoprecipitation assay showed that the formation of a ternary complex between DJ-1, DJBP, and AR occurred in cells in which DJ-1 bound to the AR via DJBP. (aacrjournals.org)
- DJ-1 was identified as a protein that transforms mouse NIH3T3 cells in cooperation with activated ras ( 1 ). (aacrjournals.org)
- With regard to the function of DJ-1 in somatic cells, we have identified PIAS (protein inhibitor of activated STAT)xα/ARIP3 (androgen receptor-interacting protein 3) as a DJ-1-binding protein ( 3 ). (aacrjournals.org)
- We have shown that PIASxα inhibits the transcription activity of the AR by binding to the DNA-binding domain of AR and that DJ-1 antagonizes this inhibition by sequestering PIASXα from the AR in CV-1, Cos1, and TM4 Sertoli cells, indicating that DJ-1 is a positive regulator of the AR ( 3 ). (aacrjournals.org)
- a protein secreted by testicular Sertoli cells along with inhibin and müllerian inhibiting substance. (thefreedictionary.com)
- The production of androgen binding protein by Sertoli Cells. (elsevier.com)
- In conclusion, these findings suggested that YB-1 induces castration resistance in androgen-dependent PCa cells via AR expression. (elsevier.com)
- Furthermore, knockdown of PCBP1 in decidualizing cells was sufficient to restore AR protein levels, indicating that loss of the AR protein is primarily the consequence of a translational block. (warwick.ac.uk)
- Therefore, PCBP1 plays a major role in the dynamic expression of AR in both male and female androgen-responsive cells. (warwick.ac.uk)
- Expression of the fusion cDNA in COS cells yielded HDC activity and the predicted size protein (Mr = 93,000) on Western immunoblots. (duke.edu)
- Cancer cells that are androgen receptor positive may need androgens to grow. (cancer.gov)
- The basic structure of autophagosome was first revealed by Ashford and Porter [ 1 ], who described membrane-bound vacuoles in rat liver cells. (intechopen.com)
- In androgen-sensitive LNCaP prostate cancer cells, AR interacts with the SH3 domain of Src within minutes of androgen treatment to promote cell survival, proliferation, and differentiation ( 5 , 6 ). (aacrjournals.org)
- In fact, androgen-activated PI3K and Akt enhance cell growth and survival in AR-positive cells, which can be inhibited by PI3K inhibitors or dominant-negative Akt. (aacrjournals.org)
- For instance, IKK2 is found to be mainly responsible for phosphorylating serine 536 in monocytes and macrophages, or in CD40 receptor binding in hepatic stellate cells. (wikipedia.org)
- In addition, transport proteins protect against sudden surges in hormone secretion and facilitate even distribution of a hormone to all of the cells of large organs such as the liver. (britannica.com)
- Bicalutamide blocks these proteins and may keep cancer cells from growing. (cancer.gov)
- Sertoli cells bind to spermatogonial cells via N-cadherins and galctosyltransferase (via carbohydrate residues). (bionity.com)
- Effects of p,p'-dichlorodiphenyldichloroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells. (bionity.com)
- Indeed, STAT3 integrates different signaling pathways involved in the reactivation of androgen receptor pathway, stem like cells and the epithelial to mesenchymal transition that drive progression to mCRPC. (mdpi.com)
- The growth response to androgen receptor signaling in ERalpha negative human breast cells is dependent on p21 and mediated by MAP kinase activation. (hopkinsmedicine.org)
- FSH, meanwhile, influences the production of sperm by triggering Sertoli cells to create androgen-binding proteins. (wisegeek.com)
- Despite being a plasma membrane protein, ErbB-3 was also detected in the nuclei of the prostate cancer cells in the metastatic specimens. (aacrjournals.org)
- These findings suggest that the bone microenvironment and androgen status influence the subcellular localization of ErbB-3 in prostate cancer cells. (aacrjournals.org)
- [6] FSH stimulates sustentacular cells to release androgen-binding protein, which promotes testosterone binding. (wikia.com)
- LH binds to the interstitial cells, causing them to secrete testosterone . (wikia.com)
- Cell signaling events triggered by androgen hormone in prostate cells is dependent on activation of the androgen receptor (AR) transcription factor. (frontiersin.org)
- In this work, we performed RNA-seq deep-sequencing of LNCaP prostate cancer cells and found over 7000 expressed long intergenic non-coding RNAs (lincRNAs), of which ∼4000 are novel lincRNAs, and 258 lincRNAs have their expression activated by androgen. (frontiersin.org)
- It also binds to muscle stem cells causing them to change and become active muscle tissue. (anabolicminds.com)
- They promote the growth of both normal and cancerous prostate cells by binding to and activating a protein called the androgen receptor. (moffitt.org)
- Drugs called androgen synthesis inhibitors-these prevent the production of androgens by the adrenal glands and prostate cells themselves, as well as by the testicles. (moffitt.org)
- He was a discoverer of androgen-binding proteins, which are produced by the Sertoli cells of the testes and influence epididymal function and sperm maturation. (vanderbilt.edu)
Testosterone binds1
- When testosterone binds to the AR, the testosterone/AR complex can enter the cell nucleus. (mda.org)
Transcription factor7
- Y-box binding protein-1 (YB-1) is a pleiotropic transcription factor that is upregulated in CPRC. (elsevier.com)
- The androgen receptor (AR) is a ligand-dependent transcription factor, expressed in male and female reproductive organs, and essential for normal reproduction in both sexes. (warwick.ac.uk)
- The androgen receptor (AR), a ligand-dependent transcription factor and member of the class I subgroup of the nuclear receptor superfamily, plays a key role in prostate carcinogenesis and progression. (aacrjournals.org)
- Alignment of the human, mouse, rat, rabbit and dog promoters reveals several highly conserved transcription factor-binding sites. (biochemj.org)
- Gel electrophoretic mobility-shift assays, chromatin immunoprecipitation studies and co-transfection experiments with plasmids expressing these transcription factors or dominant-negative versions of these factors showed that NF-YA (nuclear transcription factor Yα), AP2 (activator protein 2), Nrf1 (nuclear respiratory factor/α-Pal) and Sp1 (specificity protein 1) all bind to the FXR2 promoter both in vitro and in vivo and positively regulate the FXR2 promoter. (biochemj.org)
- Androgens act through the androgen receptor (AR), which is a ligand-modulated transcription factor. (pubmedcentralcanada.ca)
- Prostate cancer is the second most common cause of cancer-associated deaths in men and signalling via a transcription factor called androgen receptor (AR) is an important driver of the disease. (psu.edu)
Epididymis1
- Androgen binding protein (ABP) was measured during postnatal development in normal and irradiated rats to determine whether development of a blood-testis barrier and formation of a continuous lumen from testis to epididymis is correlated with entry of ABP into the caput epididymis. (nih.gov)
Regulation5
- Repression of AR-mediated transcription is achieved, in part, by URI binding and regulation of androgen receptor trapped clone 27 (Art-27), a previously characterized AR corepressor. (scripps.edu)
- The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease processes. (bio-rad.com)
- [ 10 ] Up-regulation or activation of transcription results in increased synthesis of messenger RNA which in turn is transcribed by ribosomes to produce specific proteins. (thefullwiki.org)
- A recent PCa whole-genome sequencing study revealed a significant correspondence between DNA breakpoints and AR-binding sites implicating an inter-play between hormone regulation and genomic events 5 . (nature.com)
- His research has focused on male reproductive biology and made significant contributions to the body of knowledge in the areas of hormonal regulation of epididymal function, androgen-binding proteins (ABP) and the effects of xenobiotics on reproductive health. (vanderbilt.edu)
Regulate3
- These data identify novel nongenomic mechanisms involving androgen, AR, and Hsp27 activation that cooperatively interact to regulate the genomic activity of AR and justify further investigation of Hsp27 knockdown as an AR disrupting therapeutic strategy in prostate cancer. (aacrjournals.org)
- Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. (genecards.org)
- In prostate cancer, mutations in the AR can make it able to regulate transcription without the need to bind androgen. (brightsurf.com)
Secretion1
- A protein complex, related to inhibin, that enhances FSH biosynthesis and secretion. (studystack.com)
LNCaP2
- Furthermore, knockdown of PCBP1 in the prostate cancer LNCaP cell line also increased AR protein. (warwick.ac.uk)
- We mimicked these conditions by overexpressing FOXA1 in the androgen-responsive LNCaP prostate cancer cell line and observed a significant increase in AR genomic binding at novel regions that possess increased chromatin accessibility. (nih.gov)
Synthesis7
- Related to the mechanism underlying androgen activation of the SREBP pathway, we show that in addition to minor effects on SREBP precursor levels, androgens induce a major increase in the expression of sterol regulatory element-binding protein cleavage-activating protein (SCAP), an escort protein that transports SREBPs from their site of synthesis in the endoplasmic reticulum to their site of proteolytical activation in the Golgi. (nih.gov)
- Permease s in the lysosomal membrane, for example, allow amino acids generated inside the lysosome to cross into the cytoplasm, where they can be used for the synthesis of new proteins. (britannica.com)
- These influences dynamically control the liver synthesis of this carrier protein. (labcorp.com)
- As Verjovski-Almeida explained, only 2% of the human genome produces messenger RNA molecules, which carry the genetic information needed for protein synthesis. (news-medical.net)
- This process increases the rate of protein synthesis. (namhaihotel.com)
- Increase in protein synthesis is the way by which testosterone manifests its anabolic nature. (energymanagertraining.com)
- There are multiple approved androgen synthesis inhibitors in the United States and they are given in pill form. (moffitt.org)
Restored androgen receptor1
- We later identified PIAS (protein inhibitor of activated STAT)xα as a DJ-1-binding protein, and found that DJ-1 restored androgen receptor (AR) transcription activity that was repressed by PIASxα. (aacrjournals.org)
Genomic4
- After this androgen-induced, non-nuclear phospho-activation, Hsp27 displaces Hsp90 from a complex with AR to chaperone AR into the nucleus and interact with its response elements to enhance its genomic activity. (aacrjournals.org)
- This nongenomic action of androgen can also influence classic genomic AR activity, including modulation of AR by coactivators ( 7 ). (aacrjournals.org)
- To discover germline events involved in prostate cancer predisposition, we develop a computational approach to nominate heritable facilitators of somatic genomic events in the context of the androgen receptor signaling. (nature.com)
- Together, these results suggest that in an androgen-depleted state, elevated levels of FOXA1 enhance AR binding at genomic regions not normally occupied by AR, which in turn facilitates prostate cancer cell growth. (nih.gov)
MRNA5
- Influence of androgens on the concentration of prostatic binding protein (PBP) and its mRNA in rat prostate. (springer.com)
- Overexpression of TBP-1 did not alter AR protein and mRNA levels. (scialert.net)
- Decidualization profoundly down-regulated AR protein levels with no discernible effect on either AR mRNA or protein stability, suggesting that loss of the receptor was a consequence of translational inhibition. (warwick.ac.uk)
- PCBP1 also blocked AR translation in a cell-free system, although this did not require binding to the 3′-untranslated region of the receptor mRNA. (warwick.ac.uk)
- Oxidative stress also generates unstable chemical species that cause damage to mRNA, DNA, and proteins involved in cell death and proliferation [ 7 ]. (hindawi.com)
Transcriptional9
- Using yeast two-hybrid screening, we previously identified Tat-binding protein-1 (TBP-1), an adenosine triphosphatase of 19S regulatory particles of the 26S proteasome, as a transcriptional coactivator of thyroid hormone receptor. (scialert.net)
- These findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP. (scialert.net)
- Here, we identify a novel feed-forward loop involving cooperative interactions between ligand-activated AR and heat-shock protein 27 (Hsp27) phospho-activation that enhance AR stability, shuttling, and transcriptional activity, thereby increasing prostate cancer cell survival. (aacrjournals.org)
- Phosphorylation at these sites enhances NF-κB transcriptional response via tightened binding to transcription coactivators. (wikipedia.org)
- Antagonizes transcriptional modulation via hepatitis B virus X protein. (genecards.org)
- Such effects of HX109 on AR signaling were mediated through the control of activating transcriptional factor 3 (ATF3) expression, phosphorylation of calcium/calmodulin-dependent protein kinase kinase β (CaMKKβ), and increases in intracellular calcium, as evidenced by data from experiments involving ATF3-specific siRNA, CaMKKβ inhibitor, and calcium chelator, respectively. (mdpi.com)
- In contrast, the interaction of antagonist-bound or mutant AR with its target was found to be kinetically different: it was dramatically faster, occurred without chromatin remodeling, and resulted in the lack of transcriptional inhibition. (pubmedcentralcanada.ca)
- Androgen hormone binding to AR promotes its displacement from the cytoplasm to the nucleus and AR binding to DNA motifs, thus inducing activatory and inhibitory transcriptional programs through a complex regulatory mechanism not yet fully understood. (frontiersin.org)
- As the androgen receptor (AR) remains a critical driver in CRPC, understanding the determinants of its transcriptional activity is important for developing new AR-targeted therapies. (nih.gov)
Ligand6
- To this end, we identified over 150 proteins/polypeptides whose ability to interact with AR is influenced in a differential manner by ligand binding. (duke.edu)
- Ligand binding leads to a conformational change in the AR and dissociation from the large Hsp complex. (aacrjournals.org)
- Protein Kinase C Assays Androgen Receptor, Ligand Binding Domain Estrogen Receptor-Beta 1, Long Form Tau Protein, microtubule-associated protein, histidine-tagged Cytochrome P450 Monoclonal Antibodies. (bioportfolio.com)
- Structure of the ligand binding domain of the androgen receptor (rainbow cartoon) complexed with testosterone (white sticks) based on PDB 2AM9 . (thefullwiki.org)
- Genetic and biochemical experiments have indicated that the LBD of AR interacts with the NTD upon ligand binding ( 7 , 14 , 27 , 32 , 82 ), which is similar to the results observed for the ER ( 39 ). (pubmedcentralcanada.ca)
- ERα-1 consists of the ligand binding domain and ERα-2 consists of the DNA binding domain. (igem.org)
Pathways4
- Activation of alternative growth factor pathways after androgen withdrawal is one mechanism mediating androgen-independent (AI) progression in advanced prostate cancer. (aacrjournals.org)
- One mechanism mediating AI progression in advanced prostate cancer involves activation of alternative growth factor pathways after androgen withdrawal. (aacrjournals.org)
- URI is phosphorylated upon androgen treatment, suggesting communication between the URI and AR signaling pathways. (scripps.edu)
- Here, we describe the crucial role of 5′-AMP-activated protein kinase (AMPK) as master regulator of lipogenic pathways as well as of intracellular oncogenic signaling [i.e., the mammalian target of rapamycin (mTOR) pathway]. (aacrjournals.org)
Seminiferous tubules1
- Androgen binding protein probably maintains a high concentration of androgen in the seminiferous tubules. (thefreedictionary.com)
Cytoplasm1
- Triggered by lipopolysaccharide (LPS), protein kinase A (PKA) specifically phosphorylates serine 276 in the RHD domain in the cytoplasm, controlling NF-κB DNA-binding and oligomerization. (wikipedia.org)
Androgenic1
- Androgens and gestagens with androgenic residual action have the opposite effect. (labcorp.com)
Prostate cancer cell2
- Androgen receptor (AR) transactivation is known to enhance prostate cancer cell survival. (aacrjournals.org)
- We speculate that nuclear localization of ErbB-3 may aid prostate cancer cell survival during androgen ablation and progression of prostate cancer in bone. (aacrjournals.org)
Castration-resistant prostate cancer1
- However, patients can develop resistance to this therapy and progress to androgen-independent, or castration-resistant, prostate cancer. (brightsurf.com)
Produce androgens1
- Drugs called luteinizing hormone-releasing hormone (LHRH) agonists or LHRH antagonists-these cause the pituitary gland to stop producing luteinizing hormone, and as a result the testicles are not stimulated to produce androgens. (moffitt.org)
Interaction7
- Recent progress in the development of protein-protein interaction inhibitors targeting androgen receptor-coactivator binding in prostate cancer. (nih.gov)
- Structural analyses of the AR have identified key surfaces involved in protein-protein interaction with coregulators that have been recently used to design and develop promising AR-coactivator binding inhibitors. (nih.gov)
- Androgen receptor (AR)-mediated transcription is modulated by interaction with coregulatory proteins. (scripps.edu)
- Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. (duke.edu)
- Thus, we asked whether differential presentation of protein-protein interaction surfaces on the androgen receptor (AR), a surrogate assay of receptor conformation, could be used in a prospective manner to define the pharmacological activity of bound ligands. (duke.edu)
- RHD is involved in DNA binding, dimerization and NF-κB/REL inhibitor interaction. (wikipedia.org)
- The ovarian androgen excess may be because of an interaction between obesity-related, chronic hyperinsulinemia with genetic factors predisposing to the development of ovarian hyperandrogenism. (aacrjournals.org)
Receptor tyrosin2
- The ErbB family of membrane proteins consists of receptor tyrosine kinases that mediate cell growth and differentiation through the binding of their ligands ( 1 ). (aacrjournals.org)
- Androgen treatment is known to affect the expression and activity of other oncogenes including receptor tyrosine kinases (RTKs). (psu.edu)
Biosynthesis2
- We found that ERBB4 activates sterol regulatory element binding protein-2 (SREBP-2) to enhance low-density lipoprotein (LDL) uptake and cholesterol biosynthesis. (sciencemag.org)
- Thus, many of the drugs to target that cancer focus on stopping androgen biosynthesis or blocking the androgen receptor. (brightsurf.com)
Testicular feminization1
- Deficiency of DHT binding protein (s) could account for the syndrome of androgen insensitivity (testicular feminization) in man. (utmb.edu)
Dimer binds2
- Each dimer binds one molecule of steroid. (uniprot.org)
- The androgen receptor dimer binds to a specific sequence of DNA known as a hormone response element . (thefullwiki.org)
Nuclear receptor1
- The datasets were derived from competitive binding assays for the estrogen and androgen nuclear receptor proteins that were validated and carried out at the NCTR. (fda.gov)
Molecular1
- Novel therapeutic strategies that target the molecular basis of androgen and chemoresistance may provide an opportunity to delay progression and prolong survival. (aacrjournals.org)
Steroids3
- An androgen binding protein (ABP) was demonstrated in the 105,000 g supernatant of rat testis homogenate after charcoal extraction of endogenous steroids. (elsevier.com)
- Planar C 18 and C 19 steroids with a 17α-hydroxyl group bind particularly well, 3,4 whereas C 19 17-ketosteroids, such as dehydroepiandrosterone (DHEA) and androstenedione, do not bind so easily. (labcorp.com)
- Endogenous androgens are C-19 steroids with a side chain at C-17, and with two angular methyl groups. (rxlist.com)
Phosphorylation6
- Gao Y, Chen S (2013) Proline-Directed Androgen Receptor Phosphorylation. (omicsonline.org)
- Androgen-bound AR induces rapid Hsp27 phosphorylation on Ser 78 and Ser 82 residues in an AR- and p38 kinase-dependent manner. (aacrjournals.org)
- Phosphorylation of serine 311 by protein kinase C zeta type (PKCζ) serves the same purpose. (wikipedia.org)
- The fact that RELA can be modified by a collection of kinases via phosphorylation at different sites/regions within the protein under different stimulations might suggest a synergistic effect of these modifications. (wikipedia.org)
- In vivo studies revealed that RELA is also under acetylation modification in the nucleus, which is just as important as phosphorylation as a post-translational modification of proteins. (wikipedia.org)
- part, le récepteur à l'IGF (IGF-R1) à activité tyrosine kinase interagit avec la voie de signalisation du RA en modulant sa phosphorylation et donc son activité, induisant sa translocation nucléaire (=-=Wu et al. (psu.edu)
Serum4
- Does fluoride affect serum testosterone and androgen binding protein with age-specificity? (fluoridealert.org)
- The aim of this study is to explore the association of fluoride exposure and age with serum T and androgen-binding protein (ABP) levels in male farmers. (fluoridealert.org)
- to a serum carrier or transport protein. (britannica.com)
- The highest expression levels together with strong repression in pre-culture were achieved with the novel promoters PG1 and PG6.Human serum albumin (HSA) was used to characterize the promoters with an industrially relevant secreted protein. (biomedsearch.com)
Prostatic2
- Androgen binding proteins in human prostatic hyperplasis. (semanticscholar.org)
- The amount of binding per cell and the dissociation constant measured in normal fibroblasts is comparable to reported values for prostatic tissue. (utmb.edu)
Proliferation1
- Among these, androgen dysregulation is particularly important, as it can induce prostate cell proliferation. (mdpi.com)
Stimulate1
- Androgens also rapidly stimulate Raf-1 and Erk-2, both components of the MAPK signaling cascade ( 5 ), suggesting that androgen-stimulated MAPK activation occurs via nongenomic mechanisms. (aacrjournals.org)
Transactivation1
- Like other proteins in this complex, RELA contains a N-terminal REL-homology domain (RHD), and also a C-terminal transactivation domain (TAD). (wikipedia.org)
Recombinant Proteins2
- Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
- CONCLUSIONS: A set of novel regulated promoters, enabling induction without methanol, was successfully identified by using DNA microarrays and shown to be suitable for high level expression of recombinant proteins in glucose-based protein production processes. (biomedsearch.com)
Male7
- With regard to the function of DJ-1 in sperm, a rat homologue of human DJ-1 has been identified by other laboratories as a key protein related to infertility of male rats that had been exposed to sperm toxicants such as ornidazole and epichlorohydrin ( 23 -26 ). (aacrjournals.org)
- a condition whereby a genetically male individual cannot respond to androgens in blood. (studystack.com)
- The androgen receptor is a protein that binds to the male sex hormone, testosterone. (mda.org)
- Androgens have key roles in normal physiology and in male sexual differentiation as well as in pathological conditions such as prostate cancer. (pubmedcentralcanada.ca)
- Androgens have a critical role in the development and maintenance of the male reproductive system and have roles in physiological and pathological conditions, including the normal prostate and prostate cancer (for reviews, see references 34 and 37 ). (pubmedcentralcanada.ca)
- Androgens (contained in this combination medicine) should not be used during pregnancy because they may cause male-like changes in a female baby. (drugs.com)
- However, androgens may cause unwanted effects in nursing babies such as too early sexual development in males or male-like changes in females. (drugs.com)
Antibodies2
- Production and use of antibodies to mouse salivary androgen binding protein. (springer.com)
- The protein was immunoprecipitable by human autoimmune antibodies to the androgen receptor. (sciencemag.org)
Salivary5
- Immunohistochemical detection of proteins on electroblots of polyacrylamide electrophoresis and isoelectric focusing gels, however shows that the prostate CRM is a protein with electrophoretic and isoelectric focusing behavior distinct from that of salivary ABP isoproteins. (springer.com)
- The tissue source and cellular control of the apparent size of Androgen binding protein (Abp), a mouse salivary protein whose electrophoretic mobility is under the control of sex-limited saliva pattern (Ssp) . (springer.com)
- Human salivary proline-rich (Pr) proteins: A posttranslational derivation of the phenotypes. (springer.com)
- We have searched for genetic variation in the expression of salivary androgen-binding protein (ABP) in a wide variety of mice and other rodents. (elsevier.com)
- Karn, RC & Dlouhy, SR 1991, ' Salivary androgen-binding protein variation in Mus and other rodents ', Journal of Heredity , vol. 82, no. 6, pp. 453-458. (elsevier.com)