Androgen-Binding Protein: Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.Testis: The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.Receptors, Androgen: Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.Androgen-Insensitivity Syndrome: A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY.Testosterone Congeners: Steroidal compounds related to TESTOSTERONE, the major mammalian male sex hormone. Testosterone congeners include important testosterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with androgenic activities.Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Sex Hormone-Binding Globulin: A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Sertoli Cells: Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.

Effects of spinal cord injury on spermatogenesis and the expression of messenger ribonucleic acid for Sertoli cell proteins in rat Sertoli cell-enriched testes. (1/242)

The study was an examination of the effects of spinal cord injury (SCI) on spermatogenesis and Sertoli cell functions in adult rats with Sertoli cell-enriched (SCE) testes. The effects of SCI on the seminiferous epithelium were characterized by abnormalities in the remaining spermatogenic cells during the first month after SCI. Three days after SCI, serum testosterone levels were 80% lower, while serum FSH and LH levels were 25% and 50% higher, respectively, than those of sham control SCE rats. At this time, the levels of mRNA for androgen receptor (AR), FSH receptor (FSH-R), and androgen-binding protein (ABP) were normal whereas those for transferrin (Trf) had decreased by 40%. Thereafter, serum testosterone levels increased, but they remained lower than those of the sham control rats 28 days after SCI; and serum FSH and LH levels returned to normal. The levels of mRNA for AR, ABP, and Trf exhibited a biphasic increase 7 days after SCI and remained elevated 28 days after SCI. FSH-R mRNA levels were also elevated 90 days after SCI. Unexpectedly, active spermatogenesis, including qualitatively complete spermatogenesis, persisted in > 40% of the tubules 90 days after SCI. These results suggest that the stem cells and/or undifferentiated spermatogonia in SCE testes are less susceptible to the deleterious effects of SCI than the normal testes and that they were able to proliferate and differentiate after SCI. The presence of elevated levels of mRNA for Sertoli cell FSH-R and AR, as well as of that for the Sertoli cell proteins, in the SCE testes during the chronic stage of SCI suggests a modification of Sertoli cell physiology. Such changes in Sertoli cell functions may provide a beneficial environment for the proliferation of the stem cells and differentiation of postmeiotic cells, thus resulting in the persistence of spermatogenesis in these testes.  (+info)

Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor. (2/242)

The induction of immunity genes in Drosophila has been proposed to be dependent on Dorsal, Dif, and Relish, the NF-kappaB-related factors. Here we provide genetic evidence that Dif is required for the induction of only a subset of antimicrobial peptide genes. The results show that the presence of Dif without Dorsal is sufficient to mediate the induction of drosomycin and defensin. We also demonstrate that Dif is a downstream component of the Toll signaling pathway in activating the drosomycin expression. These results reveal that individual members of the NF-kappaB family in Drosophila have distinct roles in immunity and development.  (+info)

Characterization of lipid efflux particles generated by seminal phospholipid-binding proteins. (3/242)

We reported recently that the choline phospholipid-binding proteins (BSP-A1/-A2, BSP-A3 and BSP-30-kDa) of bovine seminal plasma (BSP) stimulate cholesterol and choline phospholipid efflux from fibroblasts. In this study, we characterized the lipid efflux particles generated by BSP proteins. The density gradient ultracentrifugation of the efflux medium from radiolabeled fibroblasts incubated with BSP proteins showed a single peak of [3H]cholesterol between density (d) 1.12 and 1.14 g/ml, which is in the range of high-density lipoproteins. Size-exclusion chromatographic and immunoblot analysis revealed that the efflux particles have a large size equal to or bigger than very low-density lipoproteins and contained BSP proteins. Lipid analysis of density gradient and gel filtration fractions from efflux medium of simultaneously labeled fibroblasts ([3H]cholesterol and [3H]choline) incubated with BSP proteins showed that the efflux particles were homogeneous and composed of cholesterol and choline phospholipids. The lipid particles contained BSP proteins, cholesterol and choline phospholipids in molar ratio of 0.05:1.21:1, respectively. Agarose gel electrophoresis showed that the BSP-generated lipid particles had a gamma migration pattern which is slower than low-density lipoproteins. The sonication of cholesterol and BSP proteins followed by gel filtration chromatographic analysis indicated no direct binding of cholesterol to BSP proteins. These results taken together indicate that BSP proteins induce a concomitant cholesterol and choline phospholipid efflux and generate large protein-lipid particles.  (+info)

Selective activation of the probasin androgen-responsive region by steroid hormones. (4/242)

Glucocorticoid and androgen receptors have been shown to function through the same palindromic glucocorticoid response element (GRE) and yet have differential effects on gene transcription. In this study, we examined the functional and structural relationship of the androgen and glucocorticoid receptors with the androgen responsive region (ARR) of the probasin (PB) gene containing two androgen receptor binding sites, ARBS-1 and ARBS-2. Transfection studies indicated that one copy of each cis-acting DNA element was essential for maximal androgen-induced chloramphenicol acetyltransferase (CAT) activity and that androgen selectivity was maintained when multiple copies of the minimal wild type (wt) androgen responsive region containing both ARBS-1 and ARBS-2 (-244 to -96) were subcloned in front of the thymidine kinase promoter. Furthermore, replacing the androgen response region with 1, 2 or 3 copies of either ARBS-1 or ARBS-2 restored less than 4% of the biological activity seen with the wt PB ARR. Multiple copies of either ARBS-1 or ARBS-2 did not result in glucocorticoid-induced CAT gene activity. By comparison, 1 or 2 copies of the tyrosine aminotransferase (TAT) GRE, as well as the mouse mammary tumour virus GRE, were strong inducers of CAT activity in response to both androgen and glucocorticoid treatment. In addition, band shift assays demonstrated that although the synthetic glucocorticoid receptor, GR-DNA binding domain (GR-DBD), and the synthetic androgen receptor, AR2, could interact with the TAT GRE (dissociation constants Kd of 63.9 and 14.1 respectively), only AR2 but not GR-DBD binding could be detected on ARBS-1 and ARBS-2. Our findings provide further evidence that androgen-induced regulation of gene transcription can occur through androgen-specific DNA binding sites that are distinct from the common GRE.  (+info)

The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts. (5/242)

CV787, a novel highly prostate-specific replication-competent adenovirus with improved efficacy, was constructed. CV787 contains the prostate-specific rat probasin promoter, driving the adenovirus type 5 (Ad5) E1A gene, and the human prostate-specific enhancer/promoter, driving the E1B gene. To improve efficacy, we constructed CV787 such that it also contains the entire Ad5 E3 region. CV787 replicates in prostate-specific antigen (PSA)+ cells as well as wild-type adenovirus, but in PSA- cells, CV787 replicates 10(4)-10(5) times less efficiently. CV787 destroys PSA+ prostate cancer cells 10,000 times more efficiently than PSA- cells. Incorporation of the Ad5 E3 region significantly improves the target cell killing ability or efficacy of CV787. In nu/nu mice carrying s.c. LNCaP xenografts, a single i.v. tail vein injection of CV787 eliminates 300-mm3 tumors within 4 weeks. CV787 could be a powerful therapeutic for human metastatic prostate cancer.  (+info)

Reduced nucleotide variability at an androgen-binding protein locus (Abpa) in house mice: evidence for positive natural selection. (6/242)

Previous work has shown that the gene for the alpha subunit of androgen-binding protein, Abpa, may be involved in premating isolation between different subspecies of the house mouse, Mus musculus. We investigated patterns of DNA sequence variation at Abpa within and between species of mice to test several predictions of a model of neutral molecular evolution. Intraspecific variation among 10 Mus musculus domesticus alleles was compared with divergence between M. m. domesticus and M. caroli for Abpa and two X-linked genes, Glra2 and Amg. No variation was observed at Abpa within M. m. domesticus. The ratio of polymorphism to divergence was significantly lower at Abpa than at Glra2 and Amg, despite the fact that all three genes experience similar rates of recombination. Interspecific comparisons among M. m. domesticus, Mus musculus musculus, Mus musculus castaneus, Mus spretus, Mus spicilegus, and Mus caroli revealed that the ratio of nonsynonymous substitutions to synonymous substitutions on a per-site basis (Ka/Ks) was generally greater than one. The combined observations of no variation at Abpa within M. m: domesticus and uniformly high Ka/Ks values between species suggest that positive directional selection has acted recently at this locus.  (+info)

Heterotopic endochondrial ossification with mixed tumor formation in C3(1)/Tag transgenic mice is associated with elevated TGF-beta1 and BMP-2 expression. (7/242)

Transgenic mice which express the simian virus 40 large T-antigen (Tag) under the regulatory control of the hormone responsive rat C3(1) gene develop unusual lesions of heterotopic bone growth associated with mixed tumor formation arising from eccrine sweat glands found only in the foot pads of mice, ischiocavernosus muscle adjacent to bulbourethral glands and occasionally the salivary and mammary glands. These lesions are very similar to mixed tumors arising in several types of human cancers. Based upon electron microscopic examination and immunocytochemical analyses of cellular differentiation markers, the mixed proliferative lesions in this transgenic mouse model begin with the Tag-induced proliferation of epithelial and myoepithelial cells. The proliferation of these two types of cells results in hyperplasia and adenomatous transformation of the epithelial component, whereas the proliferating myoepithelial cells undergo metaplasia to form chondrocytes which deposit extracellular matrix, including collagen fibers. Cartilage develops focally between areas of epithelial proliferation and subsequently ossifies through a process of endochondrial bone formation. The metaplasia of myoepithelial cells to chondrocytes appears to require the inductive interaction of factors produced by the closely associated proliferating epithelial cells, including members of the TGF-beta superfamily. We demonstrate that TGF-beta1 protein accumulates in the extracellular matrix of the lesions, whereas RNA in situ hybridization reveals that BMP-2, another strong inducer of heterotopic bone formation, is overexpressed by the proliferating epithelial cells during the development of ectopic bone. The formation of sarcomatous tumors within the mixed tumors appears to be androgen-dependent and more frequent in mice lacking a normal allele of p53. This process of cartilage and bone induction may mimic epithelial-mesenchymal interactions which occur during embryonic bone formation. These transgenic mice may provide new insights into the processes of ectopic endochondrial bone formation associated with mixed tumor formation and serve as a useful model for human heterotopic bone disease.  (+info)

Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces. (8/242)

Phosphatidylcholine transfer protein (Pc-tp) is a highly specific carrier of phosphatidylcholine (PC) without known function. Proposed functions include the supply of PC required for secretion into bile or lung air space (surfactant) and the facilitation of enzymatic reactions involving PC synthesis or breakdown. To test these functions, we generated knock-out mice unable to make Pc-tp. Remarkably, these mice are normal and have no defect in any of the postulated Pc-tp functions analyzed. The lipid content and composition of the bile, as well as lung surfactant secretion and composition, of Pc-tp (-/-) mice, is normal. The lack of a Pc-tp contribution to biliary lipid secretion is in agreement with our finding that Pc-tp is down-regulated in adult mouse liver: whereas Pc-tp is abundant in the liver of mouse pups, Pc-tp levels decrease > 10-fold around 2 wk after birth, when bile formation starts. In adult mice, Pc-tp levels are high only in epididymis, testis, kidney, and bone marrow-derived mast cells. Absence of Pc-tp in bone marrow-derived mast cells does not affect their lipid composition or PC synthesis and degradation. We discuss how PC might reach the canalicular membrane of the hepatocyte for secretion into the bile, if not by Pc-tp.  (+info)

*Mild androgen insensitivity syndrome

"Discordant measures of androgen-binding kinetics in two mutant androgen receptors causing mild or partial androgen ... methods to correct a malfunctioning androgen receptor protein that result from an AR gene mutation are not currently available ... "Azoospermia associated with a mutation in the ligand-binding domain of an androgen receptor displaying normal ligand binding, ... in a patient with partial androgen insensitivity and a mutation in the deoxyribonucleic acid-binding domain of the androgen ...

*Partial androgen insensitivity syndrome

"Discordant measures of androgen-binding kinetics in two mutant androgen receptors causing mild or partial androgen ... Management of AIS is currently limited to symptomatic management; methods to correct a malfunctioning androgen receptor protein ... androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome". J. Clin ... Evidence of abnormal androgen binding in a genital skin fibroblast study has long been the gold standard for the diagnosis of ...

*Testicular receptor 4

Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". The Biochemical Journal. ... Testicular receptor 4 has been shown to interact with Androgen receptor, Estrogen receptor alpha, and Hepatocyte nuclear factor ... Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Dec 2003). "Role of the TAB2-related protein TAB3 ... Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is ...

*Androgen-binding protein

Sex hormone-binding globulin (SHBG) Androgen-Binding Protein at the US National Library of Medicine Medical Subject Headings ( ... Androgen-binding protein (ABP) is a glycoprotein (beta-globulin) produced by the Sertoli cells in the seminiferous tubules of ... Because ABP binds to T and DHT, these hormones are made less lipophilic and become concentrated within the luminal fluid of the ... ABP has the same amino acid sequence as sex hormone-binding globulin (SHBG); the difference is the site of production and the ...

*ALDH1A1

"The 56 kDa androgen binding protein is an aldehyde dehydrogenase". Biochem. Biophys. Res. Commun. 175 (3): 831-8. doi:10.1016/ ... This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the ...

*Robert Vigersky

Androgen Binding Proteins of Testis, Epididymis and Plasma in Man and Monkey. Vigersky RA, Andersen AE, Thompson RH, Loriaux DL ...

*Hypothalamic-pituitary-gonadal axis

FSH stimulates sustentacular cells to release androgen-binding protein, which promotes testosterone binding. LH binds to the ... Depending on which hormone and receptor are unable to bind different effects occur but all alter the HPG axis. For example, the ... Examples of such necessary liver proteins are vitellogenin and choriogenin. The HPA, HPG, and HPT axes are three pathways in ... GnRH travels down the anterior portion of the pituitary via the hypophyseal portal system and binds to receptors on the ...

*Androgen receptor

Heinlein CA, Chang C (October 2002). "The roles of androgen receptors and androgen-binding proteins in nongenomic androgen ... Androgen receptors interact with certain signal transduction proteins in the cytoplasm. Androgen binding to cytoplasmic ... "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at ... "Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein ...

*Sex hormone-binding globulin

"The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs ... Androgens bind at the C3 functional groups on the A ring, and estrogens bind via a hydroxyl attached to C17 on the D ring. The ... Testes-produced SHBG is called androgen-binding protein. The gene for SHBG is called Shbg located on chromosome 17 on the short ... The amino acid sequence is the same as for androgen-binding protein but that has different oligosaccharides attached and is ...

*Sertoli cell

... and work together to regulate FSH secretion androgen binding protein (also called testosterone binding globulin) - increases ... dichlorodiphenyldichloroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells". Environ ... Sertoli cells bind to spermatogonial cells via N-cadherins and galactosyltransferase (via carbohydrate residues). During the ... This repair likely employs the process of non-homologous end joining involving XRCC1 and PARP1 proteins that are expressed in ...

*Spermatogenesis

... which is achieved via the binding of testosterone by androgen binding protein present in the seminiferous tubules. Testosterone ... FSH stimulates both the production of androgen binding protein (ABP) by Sertoli cells, and the formation of the blood-testis ... blood-testis barrier Secrete substances initiating meiosis Secrete supporting testicular fluid Secrete androgen-binding protein ... The DNA is packaged firstly with specific nuclear basic proteins, which are subsequently replaced with protamines during ...

*Follicle-stimulating hormone

FSH enhances the production of androgen-binding protein by the Sertoli cells of the testes by binding to FSH receptors on their ... In males, FSH induces Sertoli cells to secrete androgen-binding proteins (ABPs), regulated by inhibin's negative feedback ... FSH binding is thought to upregulate neovascularization via at least two mechanisms - one in the VEGF pathway, and the other ... Hypothalamic Control of Pituitary FSH-Regulatory Proteins and Their Relationship to Changes in FSH Synthesis and Secretion". ...

*Anordrin

... and A-homo-5 alpha-androstane derivatives with the androgen receptor and the epididymal androgen-binding protein". Steroids. 37 ... It binds to the estrogen receptor but does not bind to the androgen receptor or the progesterone receptor. In animals, anordrin ... Song S, Chen JK, He ML, Zuo SH, Fotherby K (1987). "Effect of Anordrin on serum levels of sex hormone binding globulin, ... Mehta RR, Jenco JM, Chatterton RT, Venton D (1982). "Antagonism of the actions of estrogens, androgens and progesterone by ...

*CYP2C18

RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene ... This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located ... Cytochrome P450 2C18 is a protein that in humans is encoded by the CYP2C18 gene. This gene encodes a member of the cytochrome ... The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of ...

*ABP

... the blood pressure in the arteries Androgen-binding protein, a glycoprotein Actin-binding protein, proteins that attach to the ... protein actin Adblock Plus, a content filtering extension for the web browsers Mozilla Firefox and Google Chrome Alternating ...

*Sustentacular cell

... androgen-binding protein, and Mullerian-inhibiting factor.. ...

*RELA

Aarnisalo P, Palvimo JJ, Jänne OA (Mar 1998). "CREB-binding protein in androgen receptor-mediated signaling". Proceedings of ... "Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with ... Parry GC, Mackman N (Dec 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB- ... Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T (Apr 1997). "CREB-binding protein/p300 are transcriptional ...

*CREB-binding protein

"The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at ... CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene. The CREB protein ... CREB-binding protein has been shown to interact with: TF2, AR, AIRE, BRCA1, C-jun, CSK, Ccaat-enhancer-binding proteins, CDX2, ... First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB), this gene is now known to play ...

*PRPF6

The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. PRPF6 ... Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. ... Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. ... Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene. The protein encoded by this gene appears ...

*TMEPAI

... an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate ... Transmembrane prostate androgen-induced protein is a protein that in humans is encoded by the PMEPA1 gene. TMEPAI has been ... an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate ... "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ...

*SPINLW1

2005). "Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif". ... Eppin is a protein that in humans is encoded by the SPINLW1 gene. This gene encodes an epididymal protease inhibitor, which ... locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein ...

*Hormonal contraception

Additionally, estrogen in the pills stimulates the liver to produce more of a protein that binds to androgens and reduces their ... Birth control pills are often prescribed to reverse the effects of excessive androgen levels, and decrease ovarian hormone ... scientists had isolated and determined the structure of the steroid hormones and found that high doses of androgens, estrogens ... as they prevent ovulation and decrease androgen production by the ovaries. ...

*DEFB118

Yenugu S, Hamil KG, Radhakrishnan Y, French FS, Hall SH (Jul 2004). "The androgen-regulated epididymal sperm-binding protein, ... "Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and ... Beta-defensin 118 is a protein that in humans is encoded by the DEFB118 gene. GRCh38: Ensembl release 89: ENSG00000131068 - ...

*CREB1

"The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at ... This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein ... Zhang Q, Vo N, Goodman RH (Jul 2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and ... CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This ...

*Androgen deprivation-induced senescence

Barakat et al (2015). CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer ... Androgen deprivation-induced senescence (or ADIS) refers to the induction of cellular senescence as a result of androgen ... "Androgen Deprivation-Induced Senescence Promotes Outgrowth of Androgen-Refractory Prostate Cancer Cells". PLoS ONE. 8 (6): ... ADIS is observed in prostate cancer cells that are dependent on androgens for cell proliferation. Androgen withdrawal induces ...

*7α-Thioprogesterone

The drug has also been assessed at steroid hormone-associated carrier proteins, and shows very low binding to sex hormone- ... as that of spironolactone and its active metabolites like 7α-thiomethylspironolactone for the rat ventral prostate androgen ... binding globulin (SHBG) but high affinity for corticosteroid-binding globulin (CBG) approximately equal to that of progesterone ... interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma". J. Clin. ...

*SYTL1

Johnson JL, Ellis BA, Noack D, Seabra MC, Catz SD (November 2005). "The Rab27a-binding protein, JFC1, regulates androgen- ... Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links ... Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links ... Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene. Model organisms have been used in the ...
Shop Androgen-binding protein ELISA Kit, Recombinant Protein and Androgen-binding protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
The synthesis of androgen-binding protein by cultured Sertoli cells is increased by insulin, retinol, follitropin and testosterone. Only follitropin will stimulate an increase in cyclic AMP in these cells, yet each agent individually increased the synthesis of androgen-binding protein in short-term cultures. For long-term culture of Sertoli cells follitropin, testosterone, insulin, and retinol appeared to act synergistically to prolong the ability of the cells to secrete androgen-binding protein. These are the first reported results which suggest an action of insulin and retinol directly on Sertoli cells even though the importance of both factors in male reproduction is known.. ...
We previously demonstrated polymorphism of a mouse salivary protein which, because of its ability to bind androgen, we designated androgen binding protein (ABP) and its structural gene, Androgen bindi
In order to study the individual steps involved in the import of phosphatidylcholine (PC) into rat liver mitochondria, a number of PC analogues were introduced into the outer membrane of isolated mitochondria. Two fluorescent PC species, i.e. 1-palmitoyl-2-(16-bimanylthio)hexadecanoyl-PC (bimane-PC) and 1-palmitoyl-2-(10-pyrene)decanoyl-PC (pyrene-PC), and one radiolabeled PC species, i.e. 1-palmitoyl-2-[1-14C]oleoyl-PC (14C-POPC), were studied. The PC analogues were introduced from small unilamellar vesicles with the use of PC-specific transfer protein. The amount of PC imported was quantified by reisolation of the mitochondria. Import of the fluorescent PC species was monitored by on-line fluorescence spectroscopy. The distribution of the newly inserted PC between the outer and the inner membrane was assessed by separation of the two membranes using digitonin treatment. All analogues tested remained exclusively localized in the outer membrane thereby suggesting that additional ...
... (Interactive Diagram) -What are the principal functional compartments of the testis? -What are the functions of the testis? -What is cryptorchidism and what are its consequences? -What is the blood-testis barrier? -What is the function of androgen-binding protein and where is it synthesized ...
... (Interactive Diagram) -What are the principal functional compartments of the testis? -What are the functions of the testis? -What is cryptorchidism and what are its consequences? -What is the blood-testis barrier? -What is the function of androgen-binding protein and where is it synthesized ...
provide nutrient and support for sermatocytes, spermatids, and spermatozoa; responsible for release of sperm and production of fluid; phagocytosis; androgen binding protein (ABP) production (maintains testosterone, FSH Ý synthesis of ABP ...
A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:A.05.360.444.849.789 ...
I went today for my appt. and it went okay. The optometrist looked at my eyes and said they look fine but my reading went to 20/25 from 20/20. Then the surgeon came in and talked with me but I felt I wasnt being heard. He was very nice but when I asked to have my eyes tested fro dry eye he said no bother since I can see your eyes are a bit dry under the scope. I asked 3 times and he just wanted to give me restasis. He thinks (I think so too) that I am just a bag of nerves and am getting myself all worked up. He first said Let me ask you the questions and then you can talk. Well, I hardly got a word in edge ways and then fumbled over what I was saying. He was in btw/ surgeries and then had to go and I said I wanted to talk more so he said make an appt. to come in and talk tomorrow morning with him. I told him that I wished I didnt have lasik and had PRK and he said no you dont ...
FLOWERING LOCUS T (FT); FUNCTIONS IN: phosphatidylethanolamine binding, protein binding; INVOLVED IN: photoperiodism, flowering, positive regulation of flower development, regulation of flower development; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidylethanolamine-binding, conserved site (InterPro:IPR001858), Phosphatidylethanolamine-binding protein PEBP (InterPro:IPR008914); BEST Arabidopsis thaliana protein match is: PEBP (phosphatidylethanolamine-binding protein) family protein (TAIR:AT4G20370.1); Has 2182 Blast hits to 2182 proteins in 306 species: Archae - 0; Bacteria - 0; Metazoa - 594; Fungi - 140; Plants - 1404; Viruses - 3; Other Eukaryotes - 41 (source: NCBI BLink ...
Background-Phosphatidylcholine Transfer Protein (PCTP) regulates the intermembrane transfer of phosphatidylcholine (PC). Higher platelet PCTP expression is associated with increased platelet responses upon activation of protease-activated receptor 4 (PAR4) thrombin receptors noted in black subjects as compared to white subjects. Little is known regarding regulation of platelet PCTP. Haplodeficiency of RUNX1, a major hematopoietic transcription factor, is associated with thrombocytopenia and impaired platelet responses upon activation. Platelet expression profiling of a patient described by us with a RUNX1 loss-of-function mutation revealed a 10-fold downregulation of PCTP gene compared with healthy controls. Methods-We pursued the hypothesis that PCTP is regulated by RUNX1 and that PCTP expression is correlated with cardiovascular events. We studied RUNX1 binding to PCTP promoter using DNA-protein binding studies and human erythroleukemia (HEL) cells, and promoter activity using luciferase ...
Shishova, E.Y., Stoll, J.M., Ersoy, B.A., Shrestha, S., Scapa, E.F., Li, Y., Niepel, M.W., Su, Y., Jelicks, L.A., Stahl, G.L., Glicksman, M., Gutierrez-Juarez, R., Cuny, G.D., Cohen, D.E. Stahl, G.L., Cuny, G.D., Cohen, D.E. Genetic Ablation or Chemical Inhibition of Phosphatidylcholine Transfer Protein Attenuates Diet-Induced Hepatic Glucose Production. Hepatology 2011, 54, 664 - 674.. Shishova, E.Y., Di Costanzo, L., Emig, F. A., Ash, D. E., Christianson, D.W. Probing the Specificity Determinants of Amino Acid Recognition by Arginase. Biochemistry 2009, 38, 121-131.. Wagle N., Xian, J., Shishova, E.Y., Wei, J., Glicksman, M.A., Cuny, G.D., Stein. R.L., Cohen. D.E. Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal. Biochem. 2008, 383, 85-92.. Shishova E.Y., Yu F., Miller D.J., Faraldos J.A., Zhao Y., Coates R.M., Allemann R.K., Cane D.E., Christianson D.W. X-ray Crystallographic Studies of Substrate Binding to Aristolochene ...
... ,The PhosphatidylEthanolamine-Binding Protein (PEBP) does not share significant homology with other serine protease inhibitors. PEBP is expressed in the central nervous system, spleen, testis, ovary, muscle, and stomach. One important role PEBP is involved in is exerting inhibitory activity agains,biological,biology supply,biology supplies,biology product
1BD9: Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction.
733 PSK has been shown to have immunoaugmenting effects in several preclinical and clinical studies carried out mainly in Japan. In the TRAMP model the tumor develops after the SV40 T-antigen transgene expression which is controlled by the rat probasin promoter in the C57BL/6 background. This model mimics the development of human prostate tumors in the sense that prostate intraepithelial neoplasia (PIN) is seen early, by 8 weeks after birth in mice, with dorsolateral prostate invasive neoplasia evolving progressively thereafter. The hypothesis is being tested that augmentation of innate and early adaptive immunity by chemical structures may retard the development of the disease: PSK is the first agent used to this end. Treatment is given i.p. starting at 4 weeks after birth; mice are sacrificed at 12 and 18 weeks, the macroscopic occurrence of tumors is recorded, as is the weight of the prostate. Body weights are also recorded. Histological evaluation of prostate lobes allows grading of the ...
There is an ever increasing amount of evidence for considering RASSF1A as a bona fide tumor suppressor gene ( 1). It remains, however, difficult to ascertain how RASSF1A can exert its tumor suppressive functions. Understanding the functions of the RASSF1A-interacting microtubule-associated protein C19ORF5 will yield greater understanding of the RASSF1A-regulated signaling pathways and ultimately will benefit our understanding of the multiple steps of carcinogenesis. Song et al. ( 18) suggested that C19ORF5 (or RABP1 as they refer to it in their article) is a centrosomal protein responsible for recruiting RASSF1A to the spindle poles where it can exert inhibitory actions on the activation of the anaphase-promoting complex/Cdc20 complex and block the prometaphase to metaphase progression. The authors have also reported that depletion of C19ORF5/RABP1 accelerates mitotic progression and increases the frequency of abnormal mitosis. We extended on these observations, but instead of using short ...
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Sequence Charts have been used for years in connection with object-oriented analysis, but the notation itself has not offered any object-oriented facilities. This is remedied by MSC-2000 MSC document as the definiton of instance kinds is a Columbi egg in connection with object orientation. The MSCs easily plays the role of methods as they are called in Java terms (or virtual functions in C++ terms) ...
Phosphatidylcholine transfer protein (PC-TP) is a phospholipid-binding protein that is enriched in liver and that interacts with thioesterase superfamily member 2 (THEM2). Mice lacking either protein exhibit improved hepatic glucose homeostasis and are resistant to diet-induced diabetes. Insulin receptor substrate 2 (IRS2) and mammalian target of rapamycin complex 1 (mTORC1) are key effectors of insulin signaling, which is attenuated in diabetes. We found that PC-TP inhibited IRS2, as evidenced by insulin-independent IRS2 activation after knockdown, genetic ablation, or chemical inhibition of PC-TP. In addition, IRS2 was activated after knockdown of THEM2, providing support for a role for the interaction of PC-TP with THEM2 in suppressing insulin signaling. Additionally, we showed that PC-TP bound to tuberous sclerosis complex 2 (TSC2) and stabilized the components of the TSC1-TSC2 complex, which functions to inhibit mTORC1. Preventing phosphatidylcholine from binding to PC-TP disrupted ...
La proteína 1 de unión a fosfatidiletanolamina (PEBP1) es una proteína codificada en humanos por el gen pebp1.[1]​[2]​ La proteína PEBP1 ha demostrado ser capaz de interaccionar con: MAP2K1[3]​ c-Raf[3]​ MAPK1[3]​ Park S, Yeung ML, Beach S, Shields JM, Yeung KC (mayo de 2005). «RKIP downregulates B-Raf kinase activity in melanoma cancer cells». Oncogene 24 (21): 3535-40. PMID 15782137. doi:10.1038/sj.onc.1208435. «Entrez Gene: PEBP1 phosphatidylethanolamine binding protein 1». Yeung, K; Janosch P, McFerran B, Rose D W, Mischak H, Sedivy J M, Kolch W (mayo. de 2000). «Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein». Mol. Cell. Biol. (UNITED STATES) 20 (9): 3079-85. ISSN 0270-7306. PMID 10757792. La referencia utiliza el parámetro obsoleto ,coautores= (ayuda ...
The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped into six subfamilies. The START domain containing 7 mRNA encodes StarD7, a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily, which was first identified as a gene overexpressed in a choriocarcinoma cell line. Recent studies show that the StarD7 protein facilitates the delivery of phosphatidylcholine to the mitochondria. This review summarizes the latest advances in StarD7 research, focusing on the structural and biochemical features, protein-lipid interactions, and mechanisms that regulate StarD7 expression. The implications of the role of StarD7 in cell proliferation, migration, and differentiation are also discussed.
The ORPs (oxysterol-binding-protein-related proteins) constitute an enigmatic family of intracellular lipid receptors that are related through a shared lipid binding domain. Emerging evidence suggests that ORPs relate lipid metabolism to membrane transport. Current data imply that the yeast ORP Kes1p is a negative regulator of Golgi-derived vesicular transport mediated by the essential phosphatidylinositol/phosphatidylcholine transfer protein Sec14p. Inactivation of Kes1p function allows restoration of growth and vesicular transport in cells lacking Sec14p function, and Kes1p function in this regard can be complemented by human ORP1S (ORP1 short). Recent studies have determined that Kes1p and ORP1S both bind phospholipids as ligands. To explore the function of distinct linear segments of ORP1S in phospholipid binding and vesicular transport regulation, we generated a series of 15 open reading frames coding for diagnostic regions within ORP1S. Purified versions of these ORP1S deletion proteins ...
The available data demonstrate that even in universal metabolic pathways, some species-specific regulatory features of structural genes are present. For instance, in the anthocyanin biosynthesis pathway (ABP), genes may be regulated by ABP-specific regulatory factors, and their expression levels may be strongly associated with anthocyanin pigmentation, or they may be expressed independently of pigmentation. A dataset of orthologous ABP genes (Chs, Chi, F3h, F3h, Dfr, Ans) from monocot and dicot plant species that have distinct gene regulation patterns and different types of pollination was constructed to test whether these factors affect the evolution of the genes. Using a maximum likelihood approach, we demonstrated that although the whole set of the ABP genes is under purifying selection, with greater selection acting on the upstream genes than on the downstream genes, genes from distinct groups of plant species experienced different strengths of selective pressure. The selective pressure on the
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The dorsoventral pattern of the Drosophila embryo is mediated by a gradient of nuclear localization of the dorsal protein which acts as amorphogen. Establishment of the nuclear concentration gradient of dorsal protein requires the activities of the 10 maternal dorsal group genes whose function results in the positive regulation of the nuclear uptake of the dorsal protein. Here we show that in contrast to the dorsal group genes, the maternal gene cactus acts as a negative regulator of the nuclear localization of the dorsal protein. While loss of function mutations of any of the dorsal group genes lead to dorsalized embryos, loss of cactusfunction results in a ventralization of the body pattern. Progressive loss of maternal cactus activity causes progressive loss of dorsal pattern elements accompanied by the expansion of ventrolateral and ventral anlagen. However, embryos still retain dorsoventral polarity, even if derived from germline clones using the strongest available, zygotic lethal cactus ...
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Key words. Methylation of DNA in CpG-rich islands is a key event in the regulation of tissue- and context-specific gene expression. Thereby, DNA methyltransferase 3A (DNMT3A) plays a pivotal role by converting cytosine to 5-methylcytosine.1 Recently, DNMT3A mutations have been described at high frequency in acute myeloid leukemia (AML), particularly with a monocytic pheno- type.2-4 In in vitro assays, mutated DNMT3A induced aberrant DNA methylation and promoted cellular proliferation. RAF kinase inhibitor protein (RKIP) negatively regulates the RAS-mitogen activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway.5 Several solid neoplasms show decreased or absent expression of RKIP and its role as a metastasis suppressor has been firmly established in animal models and studies of human tumors.5 We recently demonstrated that RKIP acts as a tumor suppressor in hematopoietic cells and that loss of RKIP expression occurs frequently in AML.6,7 Similar to mutated ...
A Saccharomyces cerevisiae mutant, initially isolated as a novobiocin sensitive mutant, was shown to be sensitive to a wide range of drugs and chemicals. In order to identify the nature of the mutation (mds1) responsible for multiple drug-sensitivity, clones from a wild-type multicopy yeast genomic library conferring drug-resistance upon the mds1 strain were characterised and sequenced. From these, multicopy, extragenic suppressors and a likely candidate (SAC1) for the wild-type MDS1 gene were identified. MDS1 was shown to be allelic to SAC1 and thus, the drug sensitive phenotype was demonstrated to be a novel phenotype associated with mutations in SAC1. SAC1 was originally isolated as a mutant suppressor of both actin (act1-1) and phosphatidylinositol/phosphatidylcholine transfer protein (PI-TP, sec14-1) mutations. Thus, a number of partially characterised mutant alleles were available for comparison with mds1. Strains containing the mds1 allele could not suppress the effects of either act1-1 ...
962 Interleukin-6 (IL-6) is a cytokine that promotes prostate cancer growth. Defining mechanisms to control IL-6 expression or its cellular targets may prove useful as a chemotherapeutic tool for the treatment of prostate cancer. IL-6 primarily mediates its effects on prostate cancer cells through the activation of the Janus kinases (JAK)/signal transducer and activators of transcription (STAT) pathway. Stat 3 represents an IL-6 response gene and is constitutively activated in prostate cancer cells and tumors. IL-6 also activates the Ras-dependent signaling pathway that includes intermediate steps involving Raf, MEK (MAP kinase kinase) and MAPK. We have shown that Raf-1 Kinase Inhibitor Protein (RKIP) disrupts the Raf-1-MEK1/2-ERK1/2 and NF-κB signaling pathways (Yeung et al., Mol Cell Biol, 21, 7207, 2001). In addition, induction of RKIP expression is required for prostate cancer cells to undergo apoptosis after exposure to clinically relevant chemotherapeutic agents (Chatterjee et al., J. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Of central importance in adapting plants of tropical origin to temperate cultivation has been selection of daylength-neutral genotypes that flower early in the temperate summer and take full advantage of its long days. A cross between tropical and temperate sorghums [Sorghum propinquum (Kunth) Hitchc. x S. bicolor (L.) Moench], revealed a quantitative trait locus, FlrAvgD1, accounting for 85.7% of variation in flowering time under long days. Fine-scale genetic mapping placed FlrAvgD1 on chromosome 6 within the physically largest centiMorgan in the genome. Forward genetic data from converted sorghums validated the QTL. Association genetic evidence from a diversity panel delineated the QTL to a 10 kb interval containing only one annotated gene, Sb06g012260, that was shown by reverse genetics to complement a recessive allele. Sb06g012260 (SbFT12) contains a phosphatidylethanolamine-binding (PEBP) protein domain characteristic of members of the FT family of flowering genes acting as a floral ...
BioAssay record AID 349716 submitted by ChEMBL: Intrinsic activity at rat androgen receptor expressed in mouse skeletal muscle C2C12 cells assessed as transcriptional activation after 24 hrs by androgen-specific response element driven luciferase reporter gene assay relative to control.
Sex steroid binding protein (SBP) and transcortin (CBG) plasma concentrations were measured in 15 postmenopausal women before and during oral administration of estradiol 2 mg plus estriol 1 mg given alone for one month and in sequential combination with noresthisterone 1 mg for the following months. The results were compared with those obtained in a group of 13 premenopausal women who were studied during the early follicular phase or during administration of estroprogestagens. The oral administration of estrogens slightly increased CBG levels (56 ...
The purpose of this study is to determine the safest dose of the multiple Raf kinase inhibitor (including c-Raf, B-Raf, and the activated mutant B-RafV600E) XL281, how often it should be taken, and how well subjects with cancer tolerate XL281. This study will also determine how the body reacts to XL281 when it is taken with and without food, and with and without Pepcid (famotidine), a drug that inhibits stomach acid production ...
Prior to IO surgery, the AFP showed 1200 and also the LDH was 100 marks above the normal. Just before the chemo started,it came down to 83 and LDH reading came to normal . AFP came to 5, after the 1st cycle with BEP regimen.But LDH went again high.My Oncologist said not to worry about LDH since there could be some infection in my body.. The doctors will never relieve the full details probably one reason been,it could bring lot of anxiety and depression to the patients and their family and also other reason could be human body changes all of a sudden with no reason though they say T.C happens in a predictable way and if doctors has said something and something else happens which was never expected, then everyone will blame the doctors for their mis-diagnosis. Everyone likes to be on the safer side and cannot complteley blame the doctors since even theyre human beings.. Also I tried to find more about the tumor marker fluctuations and behaviour but those info in detailed is not mentioned anywhere ...
Prior to IO surgery, the AFP showed 1200 and also the LDH was 100 marks above the normal. Just before the chemo started,it came down to 83 and LDH reading came to normal . AFP came to 5, after the 1st cycle with BEP regimen.But LDH went again high.My Oncologist said not to worry about LDH since there could be some infection in my body.. The doctors will never relieve the full details probably one reason been,it could bring lot of anxiety and depression to the patients and their family and also other reason could be human body changes all of a sudden with no reason though they say T.C happens in a predictable way and if doctors has said something and something else happens which was never expected, then everyone will blame the doctors for their mis-diagnosis. Everyone likes to be on the safer side and cannot complteley blame the doctors since even theyre human beings.. Also I tried to find more about the tumor marker fluctuations and behaviour but those info in detailed is not mentioned anywhere ...
Two human serum proteins, i.e. sex hormone binding globulin (h-SHBG) and corticosteroid binding globulin (h-CBG), rat corticosteroid binding globulin (r-CBG), and progesterone binding globulin (PBG)...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
after 6, 8 or 10 weeks: ( epididymal sperm content 300 ppm (15 mg/kg bw) ( rABP in testes and serum ( rABP in epididymidis variable degenerative effects in Sertoli.. 5 years colcrys 0.6 mg coupon celebrex 200 mg street value arimidex 1 mg 28 tablet viagra without side effects zoloft online paypal order amoxicillin uk elavil.she tweeted on Jan. 6, 2013,. I love this site http://kelvincruickshank.com/workshops/ amoxicillin purchase online The largest shareholders in the German real.. ❸-3-6}. De: Thaddeus (ven. 01 janv. 2016 12:26:55 CET) Whats the interest rate on this account? priligy dapoxetine side effects Boeing has for decades seen off attempts by ...
Chinnaiyan and the Michigan researchers developed the test based on their recent finding that gene fusions - pieces of chromosomes that trade places with each other, causing two genes to stick together - are common in prostate cancer, and that by overriding molecular switches that turn off excess growth, they may be the causative factor in some forms of the disease. In 2005 they identified a prostate-specific gene called TMPRSS2 which fuses with either ERG or ETV1, two genes known to be involved in several types of cancer. In 2007, they identified another five genes that fuse on to ERG or ETV1 to cause prostate cancer.. In the current study, researchers built upon the PCA3 test by screening for six additional biomarkers, including TMPRSS2:ERG as well as some molecules generally over-expressed in prostate cancer, and some which are over-expressed in specific cancer subtypes.. Researchers collected urine samples from 234 men with rising PSA levels before they underwent prostate biopsy at a ...
Ive been goin back an forth to my doc- first it was the nose spray- made it a bit better but it never solved it, then the bottle was finished it came back- then after another month I went in again and she gave me another brand and tryed that, again a bit better, 4 months ago I coughed all day every day and now its just every couple hours but the phlem is still really ...
Key Benefits: ● Proline-Rich Polypeptides (PRPs) from Fresh Colostrum ● Patented Extraction Method to Ensure Highest Quality ● Promotes Healthy Cytokine Production* ● Supports the Immune System* ● Supports Healthy Cognitive Function* ● Casein Free Colostrum Spray is a bovine colostrum immune balancing spray containing Proline-Rich Polypeptides (PRPs), which help to modulate normal immune responses.* PRPs are information-carrying proteins (peptides) with amazing adaptability. They support the bodys balanced production of cytokines by sending signals via specific cell receptor sites.* PRPs also support the thymus gland, which is known as the bodys central command for the immune system.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Bowel Restore from Neurobiologix is 100% pure bovine colostrum and natural wholefood that provides a rich source of IgG and PRPs (Proline-Rich Polypeptides).
Proline-rich Polypeptides: a protein, found within our colostrum, that helps regulate the immune system, keeping it in a balanced state between under and over-activity. This is extremely important for those persons with autoimmune disease. Proline-rich Polypeptides have a balancing effect on the immune response and can help suppress an overactive immune system in cases where it has begun to attack the tissues of the body.. Glutathione: is a combination of three simple building blocks of amino acids - cysteine, glycine and glutamine, found within our colostrum. This is the Mother of Antioxidants which acts like fly paper and all the bad things in the body stick onto it, including free radicals and toxins like mercury and other heavy metals! Not only are the (3) three amino acids found within colostrum but "Whole Food" Glutathione is abundant as well!. ...
Proline-rich Polypeptides: a protein, found within our colostrum, that helps regulate the immune system, keeping it in a balanced state between under and over-activity. This is extremely important for those persons with autoimmune disease. Proline-rich Polypeptides have a balancing effect on the immune response and can help suppress an overactive immune system in cases where it has begun to attack the tissues of the body.. Glutathione: is a combination of three simple building blocks of amino acids - cysteine, glycine and glutamine, found within our colostrum. This is the Mother of Antioxidants which acts like fly paper and all the bad things in the body stick onto it, including free radicals and toxins like mercury and other heavy metals! Not only are the (3) three amino acids found within colostrum but "Whole Food" Glutathione is abundant as well!. ...
Proline-rich Polypeptides: a protein, found within our colostrum, that helps regulate the immune system, keeping it in a balanced state between under and over-activity. This is extremely important for those persons with autoimmune disease. Proline-rich Polypeptides have a balancing effect on the immune response and can help suppress an overactive immune system in cases where it has begun to attack the tissues of the body.. Glutathione: is a combination of three simple building blocks of amino acids - cysteine, glycine and glutamine, found within our colostrum. This is the Mother of Antioxidants which acts like fly paper and all the bad things in the body stick onto it, including free radicals and toxins like mercury and other heavy metals! Not only are the (3) three amino acids found within colostrum but "Whole Food" Glutathione is abundant as well!. ...
Prostate cancer is the most commonly occurring form of non-tobacco related cancers of man in the developed world. Our understanding of the molecular pathology of prostate cancer is currently very limited. At present, clinical therapy focuses on androgen blockage by physical or pharmaceutical castration. Previous work in our molecular pathology laboratory has led to the identification of several genes whose elevated expression may contribute to the malignant progression of the prostate cancer cells. One such gene is that coding for human cutaneous fatty acid binding protein (C-F ABP). The work described in this thesis is aimed to study the specific role of C-F ABP on the tumourigenicity of prostate cancer, to investigate whether the elevated expression of C-FABP is related to androgen sensitivity of the cancer cells, and to explore the therapeutic possibility of inhibiting the development and expansion of prostate cancer through suppressing the expression of C-F ABP gene combined with the ...
The Lactopeptide in Viralox contains Proline-Rich Polypeptides (PRPs) and Lactoferrin. Both have scientific literature that proves they are effective virus fighters.
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The recognition and treatment of canine dental and oral pathology is an important component in successful management of canine health. Many dental and oral lesions occur frequently in dogs but may have a variety of presentations and treatment options.
... is a bovine colostrum based natural immune balancing spray. It contains Proline-Rich Polypeptides (PRPs) which can help modulate normal immune responses.Buy Neuro PRP spray with free shipping.
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In 1999 Congress passed the American Inventors Protection Act (AIPA) which provided among other provisions that U.S. patent applications would be published 18 months after filing.

Androgen-binding protein elisa and antibodyAndrogen-binding protein elisa and antibody

Recombinant Protein and Androgen-binding protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody ... Androgen-binding protein homolog. Androgen-binding protein homolog ELISA Kit. Androgen-binding protein homolog Recombinant. ... Protein Family Androgen-binding protein. LOG IN MY ACCOUNT CART CONTENTS CHECKOUT ... Below are the list of possible Androgen-binding protein products. If you cannot find the target and/or product is not available ...
more infohttps://www.mybiosource.com/protein_family.php?root=androgen-binding-protein

Production of an antibody to mouse salivary androgen binding protein (ABP) and its use in identifying a prostate protein...Production of an antibody to mouse salivary androgen binding protein (ABP) and its use in identifying a prostate protein...

... because of its ability to bind androgen, we designated androgen binding protein (ABP) and its structural gene, Androgen bindi ... We previously demonstrated polymorphism of a mouse salivary protein which, ... because of its ability to bind androgen, we designated androgen binding protein (ABP) and its structural gene, Androgen binding ... androgen binding proteins mouse salivary proteins mouse prostate Western transfer This work was supported in part by intramural ...
more infohttps://link.springer.com/article/10.1007%2FBF00499007

Androgen binding proteins in human prostatic hyperplasis. Methodological aspects]. - Semantic ScholarAndrogen binding proteins in human prostatic hyperplasis. Methodological aspects]. - Semantic Scholar

Androgen binding proteins in human prostatic hyperplasis. Methodological aspects]. by J Y Dubé et al. ... Androgen binding proteins in human prostatic hyperplasis. Methodological aspects].. *. J Y Dubé, Réjean Tremblay, L F Coulonval ... article{Dub1975AndrogenBP, title={[Androgen binding proteins in human prostatic hyperplasis. Methodological aspects].}, author ...
more infohttps://www.semanticscholar.org/paper/%5BAndrogen-binding-proteins-in-human-prostatic-hype-Dub%C3%A9-Tremblay/8dce7a45fc306181df86347516cc732030fe1cbe

Actions of insulin and vitamin A on Sertoli cells | Biochemical JournalActions of insulin and vitamin A on Sertoli cells | Biochemical Journal

The synthesis of androgen-binding protein by cultured Sertoli cells is increased by insulin, retinol, follitropin and ... and retinol appeared to act synergistically to prolong the ability of the cells to secrete androgen-binding protein. These are ... yet each agent individually increased the synthesis of androgen-binding protein in short-term cultures. For long-term culture ...
more infohttp://www.biochemj.org/content/186/3/1001

Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone...Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone...

The effects of the amino acid substitutions on the binding of different androgens and on the capacity of the ligand-bound ... The effects of the amino acid substitutions on the binding of different androgens and on the capacity of the ligand-bound ... The effects of the amino acid substitutions on the binding of different androgens and on the capacity of the ligand-bound ... The effects of the amino acid substitutions on the binding of different androgens and on the capacity of the ligand-bound ...
more infohttps://utsouthwestern.pure.elsevier.com/en/publications/amino-acid-substitutions-in-the-hormone-binding-domain-of-the-hum

PPT - Challenges in clinical and laboratory diagnosis of androgen insensitivity syndrome: a case report PowerPoint Presentation...PPT - Challenges in clinical and laboratory diagnosis of androgen insensitivity syndrome: a case report PowerPoint Presentation...

AIS Overview . AIS is an X-linked disorder caused by mutations in the Androgen Receptor gene Slideshow 790405 by machiko ... Challenges in clinical and laboratory diagnosis of androgen insensitivity syndrome: a case report. Caroline O.A. Melo, Daniela ... AR = Androgen Receptor. *In the absence of a ligand, the AR resides in the cytoplasm. Upon binding the receptor dimerizes and ... The AR gene codes for a protein that is a steroid-hormone- activated transcription factor and is found on the X chromosome ...
more infohttps://www.slideserve.com/machiko/challenges-in-clinical-and-laboratory-diagnosis-of-androgen-insensitivity-syndrome-a-case-report

Androgen-binding protein - WikipediaAndrogen-binding protein - Wikipedia

Sex hormone-binding globulin (SHBG) Androgen-Binding Protein at the US National Library of Medicine Medical Subject Headings ( ... Androgen-binding protein (ABP) is a glycoprotein (beta-globulin) produced by the Sertoli cells in the seminiferous tubules of ... Because ABP binds to T and DHT, these hormones are made less lipophilic and become concentrated within the luminal fluid of the ... ABP has the same amino acid sequence as sex hormone-binding globulin (SHBG); the difference is the site of production and the ...
more infohttps://en.wikipedia.org/wiki/Androgen-binding_protein

Androgen binding protein as a biochemical marker of formation of the blood-testis barrier.  - PubMed - NCBIAndrogen binding protein as a biochemical marker of formation of the blood-testis barrier. - PubMed - NCBI

Androgen binding protein as a biochemical marker of formation of the blood-testis barrier.. Tindall DJ, Vitale R, Means AR. ... Androgen binding protein (ABP) was measured during postnatal development in normal and irradiated rats to determine whether ... 2.8 pmol/mg protein) than in normal testis (0.5 pmol/mg protein). In the SCE testis neither blood-testis barrier development ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/1175511?dopt=Abstract

Androgen-Binding Protein | Profiles RNSAndrogen-Binding Protein | Profiles RNS

"Androgen-Binding Protein" by people in this website by year, and whether "Androgen-Binding Protein" was a major or minor topic ... Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of ... "Androgen-Binding Protein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Androgen-Binding Protein*Androgen-Binding Protein. *Protein, Androgen-Binding. *Androgen Binding Protein ...
more infohttp://profiles.ouhsc.edu/display/45530

Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals<...Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals<...

Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals. BMC Evolutionary ... Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals. / Laukaitis, ... Laukaitis, CM, Heger, A, Blakley, TD, Munclinger, P, Ponting, CP & Karn, RC 2008, Rapid bursts of androgen-binding protein ( ... Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals. ...
more infohttps://arizona.pure.elsevier.com/en/publications/rapid-bursts-of-androgen-binding-protein-abp-gene-duplication-occ

Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals | BMC Evolutionary...Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals | BMC Evolutionary...

... unexpected proliferation of gene duplicates encoding a family of secretoglobin proteins including the androgen-binding protein ... The tissue source and cellular control of the apparent size of androgen binding protein (Abp), a mouse salivary protein whose ... Production of an antibody to mouse salivary androgen binding protein (ABP) and its use in identifying a prostate protein ... Dlouhy RD, Taylor BA, Karn RC: The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located ...
more infohttps://0-bmcevolbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2148-8-46

Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by...Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by...

Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by ... Two of these carrier proteins, testicular androgen-binding protein (ABP) and plasma sex hormone-binding globulin (SHBG), are ... Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by ... a process that is thought to be modulated by extracellular androgen carrier proteins. ...
more infohttps://scholars.duke.edu/display/pub707155

Recent progress in the development of protein-protein interaction inhibitors targeting androgen receptor-coactivator binding in...Recent progress in the development of protein-protein interaction inhibitors targeting androgen receptor-coactivator binding in...

Androgen receptor; Coactivator binding inhibition; Coregulator recruitment; Peptidomimetics; Prostate cancer; Protein-protein ... Recent progress in the development of protein-protein interaction inhibitors targeting androgen receptor-coactivator binding in ... While frontline androgen-deprivation therapies targeting either the production or action of androgens usually yield favorable ... Structural analyses of the AR have identified key surfaces involved in protein-protein interaction with coregulators that have ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/26196120

DJBP: A Novel DJ-1-Binding Protein, Negatively Regulates the Androgen Receptor by Recruiting Histone Deacetylase Complex, and...DJBP: A Novel DJ-1-Binding Protein, Negatively Regulates the Androgen Receptor by Recruiting Histone Deacetylase Complex, and...

... androgen receptor-interacting protein 3) as a DJ-1-binding protein (3). PIASxα/ARIP3 belongs to the PIAS family of proteins, ... androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability ... After a ligand binds to the AR, the AR is translocated into the nucleus and binds to the androgen-responsive element, ARE, on ... DJBP: A Novel DJ-1-Binding Protein, Negatively Regulates the Androgen Receptor by Recruiting Histone Deacetylase Complex, and ...
more infohttp://mcr.aacrjournals.org/content/1/4/247.long

Repro Flashcards by Donovon Allen | BrainscapeRepro Flashcards by Donovon Allen | Brainscape

What does androgen binding protein do? Secreted by nurse cells it elevates androgens in tubules stimulating Spermiogenesis ...
more infohttps://www.brainscape.com/flashcards/repro-5111383/packs/6887402

Compound Report CardCompound Report Card

Testis-specific androgen-binding protein Homo sapiens 1.000 CHEMBL3746 11-beta-hydroxysteroid dehydrogenase 2 Homo sapiens ... Niemann-Pick C1-like protein 1 Homo sapiens 0.995 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Homo sapiens ... The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1473. A 1uM and 10 uM cut ... Testis-specific androgen-binding protein Homo sapiens 1.000 CHEMBL3072 Androgen Receptor Rattus norvegicus 0.999 ...
more infohttps://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1473

Compound Report CardCompound Report Card

Testis-specific androgen-binding protein Homo sapiens 1.000 CHEMBL4261 Hypoxia-inducible factor 1 alpha Homo sapiens 1.000 ... The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL384467. A 1uM and 10 uM ...
more infohttps://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL384467

Repro Session 4 Flashcards by Laura Martin | BrainscapeRepro Session 4 Flashcards by Laura Martin | Brainscape

due to high concentration of androgen binding protein 105 how are efferent ductules specialised for sperm transport? ... thick, alkaline fluid with fructose- energy source for sperms, PGs, aa and proteins, so male gamete receives nutrition and is ... bdown clotting proteins from SV secretion so semen re-liquefied 10-20 mins after ejaculation ...
more infohttps://www.brainscape.com/flashcards/repro-session-4-1923676/packs/3384166

Free Biology Flashcards about vocabulary #9Free Biology Flashcards about vocabulary #9

Androgen-binding protein. is a glycoprotein produced by the Sertoli cells in the seminiferous tubules of the testis that binds ... Androgen insensitivity syndrome. a condition whereby a genetically male individual cannot respond to androgens in blood. ... a protein coded by the KISS1 gene that is important in initiating the secretion of gonadotropin-releasing hormone in puberty. ... an androgen sex steroid produced from the conversion of testosterone in presence of the 5α-reductase enzyme. ...
more infohttps://www.studystack.com/flashcard-2916284

Scgb2b24 - PrimePCR Assay and Template | Life Science | Bio-RadScgb2b24 - PrimePCR Assay and Template | Life Science | Bio-Rad

Androgen-binding protein; Protein Abpz Assay Type: Probe Assay Design: exonic Application: Gene Expression Unique Assay ID: ... Androgen-binding protein; Protein Abpz Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5158520 Info: FAM ... Androgen-binding protein; Protein Abpz Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5158521 Info: HEX ... Androgen-binding protein; Protein Abpz Assay Type: SYBR® Green Assay Design: exonic Application: Gene Expression Unique Assay ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/gene/scgb2b24-rat

Shbg - Sex hormone-binding globulin precursor - Rattus norvegicus (Rat) - Shbg gene & proteinShbg - Sex hormone-binding globulin precursor - Rattus norvegicus (Rat) - Shbg gene & protein

Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. ... Functions as an androgen transport protein, but may also be involved in receptor mediated processes. ... Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one ... Protein-protein interaction databases. STRING: functional protein association networks. More...STRINGi. 10116. ...
more infohttp://www.uniprot.org/uniprot/P08689

Measurement of ovine plasma androgens by a competitive protein binding method : a thesis presented in partial fulfilment of the...Measurement of ovine plasma androgens by a competitive protein binding method : a thesis presented in partial fulfilment of the...

Measurement of ovine plasma androgens by a competitive protein binding method : a thesis presented in partial fulfilment of the ... A method has been developed for measuring plasma testosterone in sheep using competitive protein binding (CPB) techniques. The ... and final determination of plasma testosterone by the CPB technique using salt precipitation of the protein bound fraction. The ...
more infohttps://mro.massey.ac.nz/handle/10179/4970

NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2) | Biochemical JournalNF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2) | Biochemical Journal

Abbreviations: ABP, androgen-binding protein; aABP, alternative ABP promoter; AP2, activator protein 2; ChIP, chromatin ... androgen-binding protein) [aABP (alternative ABP promoter)]. To understand the regulation of the human FXR2 gene, we cloned the ... activator protein 2), Nrf1 (nuclear respiratory factor/α-Pal) and Sp1 (specificity protein 1) all bind to the FXR2 promoter ... The protein product of this gene, FMRP (fragile X mental retardation protein), is thought to be involved in the translational ...
more infohttp://www.biochemj.org/content/400/2/327

Associate Degree Nursing Physiology ReviewAssociate Degree Nursing Physiology Review

FSH causes sustentacular (Sertoli) cells to release androgen-binding protein (ABP). *LH stimulates interstitial (Leydig) cells ... Sperm binds to the zona pellucida and undergoes the acrosomal reaction. *Fusion of oocyte and sperm plasma membranes takes ... ABP binding of testosterone enhances spermatogenesis. Feedback inhibition on the hypothalamus and pituitary results from rising ... Surrounding the seminiferous tubules are interstitial (Leydig) cells that produce androgens. *Epididymis functions to mature ...
more infohttps://www.austincc.edu/apreview/PhysText/Reproductive.html

Afferent Input Is Necessary for Seasonal Growth and Maintenance of Adult Avian Song Control Circuits | Journal of NeuroscienceAfferent Input Is Necessary for Seasonal Growth and Maintenance of Adult Avian Song Control Circuits | Journal of Neuroscience

1979) High-affinity androgen binding proteins in syringeal tissues of songbirds. Gen Comp Endocrinol 37:286-293. ... 1981) Androgen increases protein synthesis within the avian brain vocal control system. Brain Res 222:442-446. ... 1990) Evidence for androgen receptors in sexually dimorphic perineal muscles of neonatal male rats. Absence of androgen ... 1997) Androgen control of vocal control region volumes in a wild migratory songbird (Junco hyemalis) is region and possibly age ...
more infohttp://www.jneurosci.org/content/21/7/2320.full
  • The consequences of these mutations were examined by introducing the mutations by site-directed mutagenesis into the androgen receptor cDNA sequence and expressing the mutant cDNAs in mammalian cells. (elsevier.com)
  • The tissue source and cellular control of the apparent size of Androgen binding protein (Abp), a mouse salivary protein whose electrophoretic mobility is under the control of sex-limited saliva pattern (Ssp) . (springer.com)
  • We previously demonstrated polymorphism of a mouse salivary protein which, because of its ability to bind androgen, we designated androgen binding protein (ABP) and its structural gene, Androgen binding protein (Abp) . (springer.com)
  • Immunohistochemical detection of proteins on electroblots of polyacrylamide electrophoresis and isoelectric focusing gels, however shows that the prostate CRM is a protein with electrophoretic and isoelectric focusing behavior distinct from that of salivary ABP isoproteins. (springer.com)
  • Tcp (Testosterone controlled protein): The structural gene for the mouse salivary protein under the influence of Ssp (Sex-limited saliva pattern). (springer.com)
  • Multiple gene action determining a mouse salivary protein phenotype: Identification of the structural gene for androgen binding protein (Abp). (springer.com)
  • Human salivary proline-rich (Pr) proteins: A posttranslational derivation of the phenotypes. (springer.com)
  • Seminal vesicle protein in rats: A gene in the fourth linkage group determining electrophoretic variants. (springer.com)
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • Using an antibody raised against the purified protein, we demonstrated the presence of cross-reactive material (CRM) in mouse parotid, submaxillary, sublingual, and prostate glands by double immunodiffusion. (springer.com)
  • The reason for reduced or absent CRM in the prostates of DBA/2J males is unknown but this finding suggests that there are strain-related differences in the expression of this prostate protein. (springer.com)
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