Anastomotic Leak: Breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis.Anastomosis, Surgical: Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.Esophagectomy: Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)Esophageal Diseases: Pathological processes in the ESOPHAGUS.Surgical Stapling: A technique of closing incisions and wounds, or of joining and connecting tissues, in which staples are used as sutures.Suture Techniques: Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES).Surgical Wound Dehiscence: Pathologic process consisting of a partial or complete disruption of the layers of a surgical wound.Digestive System Surgical Procedures: Surgery performed on the digestive system or its parts.Esophageal Atresia: Congenital abnormality characterized by the lack of full development of the ESOPHAGUS that commonly occurs with TRACHEOESOPHAGEAL FISTULA. Symptoms include excessive SALIVATION; GAGGING; CYANOSIS; and DYSPNEA.Colectomy: Excision of a portion of the colon or of the whole colon. (Dorland, 28th ed)Surgical Staplers: Fastening devices composed of steel-tantalum alloys used to close operative wounds, especially of the skin, which minimizes infection by not introducing a foreign body that would connect external and internal regions of the body. (From Segen, Current Med Talk, 1995)Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Radiation: Emission or propagation of acoustic waves (SOUND), ELECTROMAGNETIC ENERGY waves (such as LIGHT; RADIO WAVES; GAMMA RAYS; or X-RAYS), or a stream of subatomic particles (such as ELECTRONS; NEUTRONS; PROTONS; or ALPHA PARTICLES).Esophagoplasty: A plastic operation on the esophagus. (Dorland, 28th ed)Colostomy: The surgical construction of an opening between the colon and the surface of the body.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Colon, Sigmoid: A segment of the COLON between the RECTUM and the descending colon.Plastics: Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Esophageal Stenosis: A stricture of the ESOPHAGUS. Most are acquired but can be congenital.Colorectal Surgery: A surgical specialty concerned with the diagnosis and treatment of disorders and abnormalities of the COLON; RECTUM; and ANAL CANAL.Esophagoscopy: Endoscopic examination, therapy or surgery of the esophagus.Sigmoid Diseases: Pathological processes in the SIGMOID COLON region of the large intestine (INTESTINE, LARGE).Ileostomy: Surgical creation of an external opening into the ILEUM for fecal diversion or drainage. This replacement for the RECTUM is usually created in patients with severe INFLAMMATORY BOWEL DISEASES. Loop (continent) or tube (incontinent) procedures are most often employed.Stomach: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.Laparoscopy: A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Laparotomy: Incision into the side of the abdomen between the ribs and pelvis.Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.Gastric Bypass: Surgical procedure in which the STOMACH is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the SMALL INTESTINE by an end-to-side SURGICAL ANASTOMOSIS, depending on the amounts of intestinal surface being bypasses. This procedure is used frequently in the treatment of MORBID OBESITY by limiting the size of functional STOMACH, food intake, and food absorption.Gastrectomy: Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)Rectal Neoplasms: Tumors or cancer of the RECTUM.Capillary Leak Syndrome: A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Length of Stay: The period of confinement of a patient to a hospital or other health facility.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Surgical Wound Infection: Infection occurring at the site of a surgical incision.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Cerebrospinal Fluid Rhinorrhea: Discharge of cerebrospinal fluid through the nose. Common etiologies include trauma, neoplasms, and prior surgery, although the condition may occur spontaneously. (Otolaryngol Head Neck Surg 1997 Apr;116(4):442-9)Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Enterococcus faecalis: A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Translational Medical Research: The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.Enterococcus: A genus of gram-positive, coccoid bacteria consisting of organisms causing variable hemolysis that are normal flora of the intestinal tract. Previously thought to be a member of the genus STREPTOCOCCUS, it is now recognized as a separate genus.Enterococcus faecium: A species of gram-positive, coccoid bacteria whose organisms are normal flora of the intestinal tract. Unlike ENTEROCOCCUS FAECALIS, this species may produce an alpha-hemolytic reaction on blood agar and is unable to utilize pyruvic acid as an energy source.Gram-Positive Bacterial Infections: Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.
A safe and reproducible anastomotic technique for minimally invasive Ivor Lewis oesophagectomy: the circular-stapled anastomosis with the trans-oral anvil. (1/105)
(+info)Effect of preoperative intraperitoneal injection of Sapylin in advanced gastric cancer. (2/105)
BACKGROUND AND OBJECTIVE: Sapylin is one of the biological response modifiers. It has been used in the comprehensive treatment for advanced cancer, and its clinical efficacy has been proved. This study was to evaluate the effect of preoperative intraperitoneal injection of Sapylin in treatment of advanced gastric cancer. METHODS: Seventy-nine patients eligible for radical gastrectomy were randomly divided into the treatment group (Sapylin + mitomycin C, 40 patients) and the control group (mitomycin C alone, 39 patients). In the treatment group, 5 KE Sapylin was injected intraperitoneally 48 h before operation and 4 mg of mitomycin C was injected into peritoneal cavity before the closure of the peritoneum. In the control group, only 4 mg mitomycin C was injected into peritoneal cavity before the closure of the peritonium. RESULTS: There was no operative mortality or duodenal stump leakage in the two groups. Postoperative complications were anastomotic leakage (2.5%, 1/40) and incision rupture (2.5%, 1/40) in the treatment group, and incision rupture (2.6%, 1/39) in the control group, with no significant difference between the two groups (P > 0.05). The 3-year survival rate was significantly higher in the treatment group than in the control group (76.5% vs. 49.4%, P < 0.05). CONCLUSIONS: Preoperative intraperitoneal injection of Sapylin can raise the 3-year survival rate after radical gastrectomy , without increasing the incidence rate of operative complications. Preoperative intraperitoneal injection of Sapylin is therefore a valuable therapy for advanced gastric cancer in clinic. (+info)Retrograde single stapling technique for laparoscopic ultralow anterior resection. (3/105)
(+info)Hybrid NOTES transgastric cholecystectomy with reliable gastric closure: an animal survival study. (4/105)
(+info)Recurrent abscess after primary successful endo-sponge treatment of anastomotic leakage following rectal surgery. (5/105)
AIM: To assess long-term efficacy of initially successful endo-sponge assisted therapy. METHODS: Between 2006 and 2009, consecutive patients who had undergone primary successful endo-sponge treatment of anastomotic leakage following rectal cancer surgery were enrolled in the study. Patients were recruited from 6 surgical departments in Vienna. Clinical and oncologic outcomes were assessed through routine endoscopic and radiologic follow-up examination. RESULTS: Twenty patients (7 female, 13 male) were included. The indications for endo-sponge treatment were anastomotic leakage (n = 17) and insufficiency of a rectal stump after Hartmann's procedure (n = 3). All patients were primarily operated for rectal cancer. The overall mortality rate was 25%. The median follow-up duration was 17 mo (range 1.5-29.8 mo). Five patients (25%) developed a recurrent abscess. Median time between last day of endo-sponge therapy and occurrence of recurrent abscess was 255 d (range 21-733 d). One of these patients was treated by computed tomography-guided drainage and in 3 patients Hartmann's procedure had to be performed. Two patients (10%) developed a local tumor recurrence and subsequently died. CONCLUSION: Despite successful primary outcome, patients who receive endo-sponge therapy should be closely monitored in the first 2 years, since recurrence might occur. (+info)Laparoscopic low anterior resection for rectal carcinoma: complications and management in 132 consecutive patients. (6/105)
AIM: To analyze the clinical manifestations and risk factors of complications in laparoscopic low anterior resection (LAR) for rectal cancer patients. METHODS: A series of 132 consecutive patients who received laparoscopic LAR for rectal cancer in our center were included. The etiology, diagnosis, treatment and prevention of rectal cancer were studied among the patients with surgery-related complications using both univariate and multivariate regression analysis. RESULTS: No conversion to open surgery was observed and 5 cases converted to hand-assisted laparoscopic operation. The overall morbidity rate was 20.5%. Complications occurred during the operation in 7 patients (5.3%), within 30 postoperative days in 24 patients (18.2%), and within 3 mo in 2 patients (1.5%). The most significant complications were anastomotic leakage (9.1%) and anastomotic hemorrhage (5.3%). Size and location of tumor, pathological staging and preoperative nutrition were significant factors associated with LAR complications, while gender, age and pathological type showed no relevance. Binary logistics regression showed that the size and location of tumor, and pathological staging were independent factors of laparoscopic LAR. All the complications were treated during their onset of clinical manifestations by interventional or conservative therapy. CONCLUSION: Anastomotic leakage is a major complication in laparoscopic LAR. The complications may be associated with tumor size and site, and pathological stage. Interventional therapies are of value in the management of laparoscopic LAR complications. (+info)The use of a compression device as an alternative to hand-sewn and stapled colorectal anastomoses: is three a crowd? (7/105)
(+info)The C-seal: a biofragmentable drain protecting the stapled colorectal anastomosis from leakage. (8/105)
(+info)Anastomotic leak is the most frequently encountered complication. Normal results for a ureterostomy include the successful ...
Cullen, JJ; Sarr, MG; Ilstrup, DM (1994). "Pancreatic anastomotic leak after pancreaticoduodenectomy: incidence, significance, ... This allows for detection of a bile leak via elevated bilirubin in the fluid drained. Pancreatic leak or pancreatic fistula, ... Three of the most common post-operative complications are: delayed gastric emptying, bile leak, and pancreatic leak. Delayed ... This new connection may leak in 1-2% of operations. As this complication is fairly common, it is normal in this procedure for ...
"Use of self-expandable plastic stents for the treatment of esophageal perforations and symptomatic anastomotic leaks". ... SEMS and self-expanding plastic stents have also been used for non-malignant conditions that cause narrowing or leaks of the ...
A number of factors may increase the risk of anastomotic dehiscence, either partial ('leak') or complete. Basic surgical ... "Postoperative nonsteroidal anti-inflammatory drugs and risk of anastomotic leak: meta-analysis of clinical and experimental ...
"Postoperative nonsteroidal anti-inflammatory drugs and risk of anastomotic leak: meta-analysis of clinical and experimental ...
The surgical risks are similar as in other bariatric techniques, including intestinal perforation, anastomotic leaks, infection ...
... such as fistula or anastomotic leaks. Cuffitis that is refractory to medication can also be a sign of Crohn's disease of the ... Chronic cuffitis can also contribute to the development of anastomotic stricture. Cuffitis that is refractory, Crohn's-related ...
All patients who developed an esophageal leak died. For this reason, modification of the original procedure was introduced to ... Significant causes of morbidity and mortality were related to complications of the esophageal transection as anastomotic ...
Endoscopic Treatment of Post-Orthotopic Liver Transplantation Anastomotic Biliary Strictures with Maximal Stent Therapy (with ... leaks (from trauma and surgery), and cancer. ERCP can be performed for diagnostic and therapeutic reasons, although the ... anastomotic strictures after liver transplantation) Hypersensitivity to iodinated contrast medium History of iodinated contrast ...
This may cause cerebrospinal fluid (CSF) to leak out into the epidural space, which may in turn cause a post dural puncture ... Evidence to support the assertion that epidural analgesia increases the risk of anastomotic breakdown following bowel surgery ... amount of the subject's own blood given into the epidural space via another epidural needle which clots and seals the leak). ...
It is important to note that, while these body fluids are sterile at first, they frequently become infected once they leak out ... and anastomotic leakage. The latter occurrence is particularly difficult to diagnose early, as abdominal pain and ileus ...
Leaks usually occur at the stomach-intestine connection (gastro-jejunostomy). Supplementing with L- glutamine has been shown to ... "Incidence of marginal ulcers and the use of absorbable anastomotic sutures in laparoscopic Roux-en-Y gastric bypass" (PDF), ... If that seal fails to form for any reason, fluid from within the gastrointestinal tract can leak into the sterile abdominal ...
"Postoperative nonsteroidal anti-inflammatory drugs and risk of anastomotic leak: meta-analysis of clinical and experimental ...
It is important to note that, while these body fluids are sterile at first, they frequently become infected once they leak out ... and anastomotic leakage. The latter occurrence is particularly difficult to diagnose early, as abdominal pain and ileus ...
This may cause cerebrospinal fluid (CSF) to leak out into the epidural space, which may in turn cause a post dural puncture ... Evidence to support the assertion that epidural analgesia increases the risk of anastomotic breakdown following bowel surgery ... amount of the subject's own blood given into the epidural space via another epidural needle which clots and seals the leak). ...
... will leak. Leaking of digestive juices and partially digested food through an anastomosis is one of the most serious ... Risks of anastomotic leaking A leaking anastomosis may cause bleeding and infection until it is treated. These leaks are ... Symptoms of anastomotic leaking. Anastomotic leaks happen in 1.5% to 6% of bypass procedures, depending on the type of surgery ... Diagnosis and treatment of anastomotic leaking. A diagnostic test used to look for anastomotic leaking is an upper GI or a CT ...
Keyword(s): abdominal, abscess, absorbable suture, air insufflation, air leak test, anastomotic complications, anterior ...
... anastomotic technique, prior leak, anastomotic type (EEA vs all others), and Covidien stapler use (all P,.05). Multivariate ... Anastomotic leaks - Is stapler brand a risk factor?. Bruce A Orkin, MD, Daniel A Popowich, MD ... patients had an IO leak identified & repaired but leaked PO. RHCs and segmental resections had low leak rates (1.7%), while ... Anastomotic leaks are one of the most feared complications of intestinal surgery. The vast majority of colonic anastomoses are ...
Anastomotic leaks present either symptomatically or asymptomatically. An. *asymptomatic leak is only detected on the routine ... association between tissue oxygenation (measured using the Wipox) at the anastomotic site and the incidence of anastomotic leak ... low levels of tissue oxygenation at the anastomotic site are associated with increased risk of anastomotic leak (AL). ... Tissue Oxygenation Are Associated With Anastomotic Leak Rates After an Ivor Lewis Esophagectomy. The safety and scientific ...
The cause of anastomotic leak remains unknown, and its incidence has not changed in decades. We demonstrate that the commensal ... We demonstrate in rats that leaking anastomotic tissues were colonized by E. faecalis strains that showed an increased collagen ... Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak ... Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak ...
Anastomotic Leak Nonoperative Management Esophageal Perforation Thoracic Esophagus Suture Repair These keywords were added by ... 1982) Modern management of anastomotic leak after esophagogastrectomy. Am J Surg 144: 94CrossRefGoogle Scholar ... Chassin J.L. (1984) Operations for Esophageal Perforations and Anastomotic Leaks. In: Operative Strategy in General Surgery. ... Nonoperative management is acceptable only in patients who have experienced a contained leak with minimal symptoms and no sign ...
Use of NERvs Inline Device as an Early Diagnostic Method for Anastomotic Leak.. The safety and scientific validity of this ... Device for the Continuous Monitoring of pH and Conductance Measurements as an Early Diagnostic Method for Anastomotic Leak.. ... Specifically the ability to detect a post-operative complication known as anastomotic leakage; which is a dreaded complication ... intended to evaluate the safety and collect preliminary data necessary for the detection of clinical post-operative anastomotic ...
Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak ... Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak ... Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak ... Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak ...
Reducing Wound Infection and Anastomotic Leaks: Resurrection of Bowel Preps, Antibiotics, and other Old Warriors 2016 , ASCRS. ... Reducing Wound Infection and Anastomotic Leaks: Resurrection of Bowel Preps, Antibiotics, and other Old Warriors 2016. ...
This may be a small leak that can be managed conservatively or less commonly complete dehiscence requiring repeat surgery. ... Colonic anastomotic leaks occur in the early or late postoperative phase, in which the enteric anastomosis fails. ... Colonic anastomotic leaks occur in the early or late postoperative phase, in which the enteric anastomosis fails. This may be a ... Colonic anastomotic leak. Dr Sachintha Hapugoda ◉ and Dr Ian Bickle et al. ...
Background Anastomotic leaks cause a significant clinical and economic burden on patients undergoing bariatric and colorectal ... For all four anastomotic leak cohorts, the occurrence of an index anastomotic leak was associated with a higher risk of all- ... As there are no specific medical codes to identify anastomotic leaks, the occurrence of anastomotic leaks was approximated ... of cases presented with a leak on index and 1.7% presented with a leak 30-day post-discharge amounting to an anastomotic leak ...
Serum Procalcitonin Predicts Anastomotic Leaks in Colorectal Surgery by Physicians Weekly , Jul 30, 2017 , 0 comments ... Background: Anastomotic leaks in colorectal surgery results in a high morbidity and mortality rate. Serum procalcitonin levels ... Result: The rate of anastomotic leak was 4.5% (3 patients) with a mortality rate of 4.3% (3 patients). A rise in serum ... The aim of this study is to determine whether serum procalcitonin is a good predictor of anastomotic leak in colorectal surgery ...
... including anastomotic leak.. OBJECTIVE:. This study aimed to determine predictors of anastomotic leak in elderly patients ... and anastomotic leak occurred in 332 (3.2%). Of the patients who developed anastomotic leak, 192 (57.8%) were men (p < 0.001). ... Predictors of Anastomotic Leak in Elderly Patients After Colectomy: Nomogram-Based Assessment From the American College of ... We constructed a stepwise multiple logistic regression model for anastomotic leak as an outcome; predictors were selected in a ...
Neutrophil to Lymphocyte Ratio and C-Reactive Protein as Two Predictive Tools of Anastomotic Leak in Colorectal Cancer Open ... in the development of anastomotic leak (AL) in patients after surgery for colorectal cancer (CRC). Methods: Patients operated ...
Anastomotic leakage is an important source of morbidity and mortality in patients undergoing neoadjuvant therapy and low ... Anastomotic leak. Of the 48 patients who received neoadjuvant therapy, 13 anastomotic leaks were identified (27%). Table 2 ... However, a contained anastomotic leak may present much later with only radiological evidence of a peri-anastomotic abscess ... Anastomotic leak was defined as any anastomotic defect resulting in pathological communication between the intra- and extra- ...
"Male gender is associated with an increased risk of anastomotic leak in rectal cancer patients after total mesorectal excision ... Anastomotic leak (AL) remains one of the major complications of TME, affecting post-operative recovery as well as cancer ... Anastomotic leak (AL) remains one of the major complications of TME, affecting post-operative recovery as well as cancer ... Male gender is associated with an increased risk of anastomotic leak in rectal cancer patients... Zhou, Chi;Wu, Xian-rui;Liu, ...
The cause of anastomotic leak remains unknown, and its incidence has not changed in decades. We demonstrate that the commensal ... Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. by Jack Gilbert, ... We demonstrate in rats that leaking anastomotic tissues were colonized by E. faecalis strains that showed an increased collagen ... faecalis at anastomotic tissues nor did they prevent leak in our rat model. Finally, we show in humans undergoing colon surgery ...
There were a total of 12/177 anastomotic leaks (6.8%). The mean time to diagnosis of anastomotic leak was 19 days (range 4-32 ... Our objective was to identify primary risk factors for anastomotic leak in OC patients undergoing RS resection to better ... only perioperative serum albumin was significantly associated with an increased risk of anastomotic leak (mean 3.4 g/dL vs. 2.4 ... CONCLUSIONS Low serum albumin is associated with an increased risk of anastomotic leak after RS resection for OC. Patients with ...
A 65-year-old man with an acute presacral anastomotic leak and large hematoma ultimately has a stoma closure and avoids a ... Endoscopic Management of Anastomotic Leak and Hematoma: A Case Study. When experience and innovation matter: A 65-year-old man ... Endoscopic Management of Anastomotic Leak and Hematoma: A Case Study. Avoiding complex reoperative abdominal surgery and ostomy ... A 65-year-old man was transferred to our hospital service from out of state for an acute presacral anastomotic leak with a ...
An anastomotic leak was treated conservatively at first for a total of three weeks. However, the leak persisted; therefore, the ... This is the first case report on the endoscopic application of cyanoacrylate alone for the treatment of an anastomotic leak. ... The leak was treated successfully with endoscopic application of n-butyl-2-cyanoacrylate. ... The endoscopic application of n-butyl-2-cyanoacrylate alone can be used successfully to treat esophagojejunal anastomotic ...
Anastomotic Leaks , Leakage, Anastomotic , Leakages, Anastomotic , Leak, Anastomotic , Leaks, Anastomotic Definition Breakdown ... Anastomotic Leak Synonyms Anastomotic Leakage , Anastomotic Leakages , ...
"Anastomotic Leak" by people in this website by year, and whether "Anastomotic Leak" was a major or minor topic of these ... "Anastomotic Leak" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Comment on: Technical factors associated with anastomotic leak after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2015 Nov- ... Below are the most recent publications written about "Anastomotic Leak" by people in Profiles. ...
... to evaluate for anastomotic leak. The findings are readily evident as contrast leak outside of the expected luminal contour. ... Anastomotic leak can occur early (2-3 days) due to technical failure or late (3-7 days) due to ischemic changes at or just ... Patients with anastomotic leak are at increased risk of stricture and fistula formation. ... IS Case 95: Post Esophagectomy Anastomotic Leak. Jared D. Christensen, MD Imaging Sciences URMC 2008. Publication Date: 2009-05 ...
Technical factors associated with anastomotic leak were open surgery (P. AB - Background Anastomotic leak is one of the most ... Technical factors associated with anastomotic leak were open surgery (P",. keywords = "Anastomotic leak, Roux-en-Y gastric ... Background Anastomotic leak is one of the most serious complications after Roux-en-Y gastric bypass (RYGB). Our objective was ... N2 - Background Anastomotic leak is one of the most serious complications after Roux-en-Y gastric bypass (RYGB). Our objective ...
When this happens, the intestinal fluids leak out into the abdomen (anastomotic leak). Surgery is needed to repair the leak. ... Anastomotic leak or stricture. An anastomosis is the area where the small intestine has been joined to the remaining stomach or ... An anastomotic stricture occurs when the tissues around the anastomosis become narrowed. This can make it difficult or painful ...
LeakageAbscessManagement of anastomotic leakResectionDevelopment of anastomoticFactors associated with anastomotic leakEndoscopyMorbidity and mortaSepsisPredictor of anastomotic leakEsophagectomyBariatric surgerySurgeryPredict anastomotic leakAbdominalStricturesFistulaStentPredictorsRate of anastomoticIntestinalIntrathoracicPost-operativeConservativelyDiagnosisStaple line leaksEndoscopicInfectionColectomyReoperationSleeve GastrectomySurg Obes Relat DisArea underPeritonitisLaparoscopicAntibioticsGastric cancerUnderwentTissue oxygenation
- We demonstrate in rats that leaking anastomotic tissues were colonized by E. faecalis strains that showed an increased collagen-degrading activity and also an increased ability to activate host MMP9, both of which contributed to anastomotic leakage. (sciencemag.org)
- Colorectal anastomotic leakage: aspects of prevention, detection and treatment. (radiopaedia.org)
- Anastomotic leakage is an important source of morbidity and mortality in patients undergoing neoadjuvant therapy and low anterior resection for rectal cancer despite use of concurrent defunctioning stoma. (omicsonline.org)
- Anastomotic leakage represents an important source of postoperative morbidity and mortality following sphincter-preserving rectal resections for malignancy. (omicsonline.org)
- Despite these well recognised issues, anastomotic leakage following low anterior resection is an unpredictable clinical phenomenon which may occur in defunctioned patients without other obvious risk factors. (omicsonline.org)
- The endoscopic application of n -butyl-2-cyanoacrylate alone can be used successfully to treat esophagojejunal anastomotic leakage. (biomedcentral.com)
- Esophagojejunal anastomotic leakage is a serious complication following total gastrectomy. (biomedcentral.com)
- The study is based on the hypothesis that patients with postoperative anastomotic leakage have a different bacterial profile contributing to poor tissue healing, and that patients operated for colon cancer presumably have a different preoperative microbiota than healthy patients. (inclinicaltrials.com)
- The objective of the study is to evaluate the feasibility of a larger study to evaluate the difference between microbiota composition of patients with and without colorectal cancer, with inflammatory bowel disease and those with and without anastomotic leakage postoperatively of a colonic resection. (inclinicaltrials.com)
- Stool samples will be taken from 20 patients, including 5 without intestinal pathology, 5 with colorectal cancer undergoing colorectal surgery, 5 with inflammatory bowel disease and 5 with anastomotic leakage after colectomy for colorectal cancer or inflammatory bowel disease. (inclinicaltrials.com)
- Anastomotic leakage is a major and potentially mortal complication with an incidence of 10-13% after resection of the rectum. (clinicaltrials.gov)
- This treatment is often associated with a very protracted postoperative course with healing times of up to a year or more for the anastomotic leakage. (clinicaltrials.gov)
- The objective of this study is to investigate the effects of transrectal vacuum treatment on the healing of anastomotic leakage after rectum resection in a prospective, randomized, controlled multicentre trial in 60 patients found to develop clinically significant anastomotic leakages after elective rectal resection. (clinicaltrials.gov)
- Patients with clinically significant* anastomotic leakage after intended curative rectal resection (LAR) for rectal cancer with primary anastomosis. (clinicaltrials.gov)
- Bell SW, Walker KG, Rickard MJ et al (2003) Anastomotic leakage after curative anterior resection results in a higher prevalence of local recurrence. (springer.com)
- Ito M, Sugito M, Kobayashi A, Nishizawa Y, Tsunoda Y, Saito N (2008) Relationship between multiple numbers of stapler firings during rectal division and anastomotic leakage after laparoscopic rectal resection. (springer.com)
- Several recent studies have investigated the role of C‐reactive protein ( CRP ) as an early marker of anastomotic leakage following colorectal surgery. (bjs.co.uk)
- A systematic literature search was performed using MEDLINE , Embase and PubMed to identify studies evaluating the diagnostic accuracy of postoperative CRP for anastomotic leakage following colorectal surgery. (bjs.co.uk)
- CRP is a useful negative predictive test for the development of anastomotic leakage following colorectal surgery. (bjs.co.uk)
- Large anastomotic leakage is always a surgical matter? (ijcrisurgery.com)
- Clemente V, Dezi A, Tarquini M, Festa V, Catarci M, Bianchi M. Large anastomotic leakage is always a surgical matter: A big leak repaired with a special stent. (ijcrisurgery.com)
- Intrathoracic esophagogastric anastomotic leakage is a life-threatening condition, with high postoperative mortality. (ijcrisurgery.com)
- The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer. (springer.com)
- Anastomotic leakage is a feared complication of gastro-esophageal surgery, as it increases recurrence, morbidity, and mortality. (springer.com)
- Nonsteroidal anti-inflammatory drugs have, however, in colorectal surgery, been shown to increase the risk of anastomotic leakage. (springer.com)
- In a historical cohort study, we investigated the impact of nonsteroidal anti-inflammatory drugs on anastomotic leakage in 557 patients undergoing surgery for gastro-esophageal-junction cancer. (springer.com)
- In univariate analysis, we did not observe any difference in age, gender, tobacco exposure, or comorbidity status between patients experiencing anastomotic leakage and those without. (springer.com)
- In multivariate analysis, gender, histology, and type of anastomosis proved to affect odds ratios for anastomotic leakage. (springer.com)
- 14.8) for use of other nonsteroidal anti-inflammatory drugs for anastomotic leakage during the first seven postoperative days. (springer.com)
- In the present study, we found a strong association between the postoperative use of ketorolac and other nonsteroidal anti-inflammatory drugs and the risk for anastomotic leakage after surgery for gastro-esophageal-junction cancers. (springer.com)
- Intrathoracic anastomotic leakage after gastroesophageal cancer resection is associated with increased risk of recurrence. (springer.com)
- Predictors and outcome of cervical anastomotic leakage after esophageal cancer surgery. (semanticscholar.org)
- BACKGROUND Anastomotic leakage after esophagectomy remains an important source of postoperative morbidity in spite of advances in the management of these patients. (semanticscholar.org)
- The aim of this study is to identify the predictive factors of cervical anastomotic leakage and its consequences after esophagectomy in patients with esophageal cancer treated in a high volume cancer center. (semanticscholar.org)
- Critical appraisal of the significance of intrathoracic anastomotic leakage after esophagectomy for cancer. (semanticscholar.org)
- Anastomotic leakage post-esophagogastrectomy for esophageal carcinoma: retrospective analysis of predictive factors, management and influence on longterm survival in a high volume centre. (semanticscholar.org)
- The rate of anastomotic leakage. (patientsville.com)
- However, a contained anastomotic leak may present much later with only radiological evidence of a peri-anastomotic abscess cavity on subsequent contrast imaging with minimal or no clinical symptoms [ 11 ]. (omicsonline.org)
- For the past decade, we have developed a range of novel endoscopic techniques to manage strictures, fistula, anastomotic leak and abscess, including endoscopic stricturotomy, endoscopic sinusotomy, endoscopic septectomy, endoscopic fistulotomy, endoscopic incision and drainage, endoscopy-guide seton and drainage catheter placement. (clevelandclinic.org)
- 1982) Modern management of anastomotic leak after esophagogastrectomy. (springer.com)
- In one large surgical series, the incidence anastomotic leak after colorectal resection was 8.7% 1 . (radiopaedia.org)
- 2015) Predicting Risk of Anastomotic Leak in Patients Undergoing Neoadjuvant Radiotherapy and Low Anterior Resection for Rectal Cancer. (omicsonline.org)
- Low platelet and white cell counts at the time of surgery may be associated with an increased risk of anastomotic leak in patients undergoing low anterior resection following preceding neoadjuvant therapy. (omicsonline.org)
- The objective of this study was to evaluate whether any pre-operative haematological parameters may be associated with increased risk of anastomotic leak in patients undergoing initial neoadjuvant therapy and subsequent low anterior resection with concurrent defunctioning stoma for rectal cancer. (omicsonline.org)
- Risk factors for anastomotic leak after recto-sigmoid resection for ovarian cancer. (semanticscholar.org)
- OBJECTIVES Anastomotic leak after recto-sigmoid (RS) resection for ovarian cancer (OC) is a life-threatening complication. (semanticscholar.org)
- Our objective was to identify primary risk factors for anastomotic leak in OC patients undergoing RS resection to better determine who would most benefit from protective diversion. (semanticscholar.org)
- En bloc pelvic resection for advanced ovarian cancer preceded by central ligation of vessels supplying the tumor bed: a description of surgical technique and a feasibility study. (semanticscholar.org)
- The shared blood supply of the pancreas, duodenum and common bile duct, necessitates en bloc resection of these multiple structures. (wikipedia.org)
- Purpose: To assess the prognostic value of postoperative C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) in the development of anastomotic leak (AL) in patients after surgery for colorectal cancer (CRC). (ovid.com)
- Are gut bacteria associated with the development of anastomotic leaks? (springer.com)
- Comment on: Technical factors associated with anastomotic leak after Roux-en-Y gastric bypass. (ouhsc.edu)
- Use an upper endoscopy to place a temporary stent across the leaking area, from the inside of the gastric pouch or the small intestine. (hopkinsmedicine.org)
- If an anastomotic leak is suspected, a water-soluble contrast study is indicated before endoscopy. (medscape.com)
- Endoscopy revealed an anastomotic stricture, and dilation was performed with a through-the-scope balloon dilator (Figure 6 A-C). (medscape.com)
- An accurate prediction of anastomotic leak affecting morbidity and mortality after colorectal surgery using the proposed nomogram may facilitate decision making in elderly patients for healthcare providers. (ovid.com)
- Background: Anastomotic leaks in colorectal surgery results in a high morbidity and mortality rate. (physiciansweekly.com)
- Although bleeding from the anastomotic site is well documented and various managements have been outlined delayed bleeding from the presacral vein due to pelvic sepsis after total mesorectal excision has not been reported. (sages.org)
- Nonoperative management is acceptable only in patients who have experienced a contained leak with minimal symptoms and no sign of systemic sepsis. (springer.com)
- Anastomotic leak may be clinically evident in the early postoperative period with the typical findings resulting from progressive pelvic sepsis. (omicsonline.org)
- Serum procalcitonin levels is known as a sensitive and specific marker of sepsis and could be use as a marker for early detection of a leak allowing early intervention. (physiciansweekly.com)
- Although endoluminal stents may not lead to resolution of a chronic leak or stricture, SEMS may suppress ongoing sepsis and allow patients to undergo nutritional resuscitation orally before operative correction. (elsevier.com)
- The aim of this study is to determine whether serum procalcitonin is a good predictor of anastomotic leak in colorectal surgery. (physiciansweekly.com)
- The primary objective of this observational study is to determine whether in patients undergoing Ivor Lewis esophagectomy, low levels of tissue oxygenation at the anastomotic site are associated with increased risk of anastomotic leak (AL). (clinicaltrials.gov)
- Many surgeons believe that radical en-bloc esophagectomy improves the cure rate, even in cases of lymph node involvement. (medscape.com)
- Timing of Esophagectomy after Neoadjuvant Chemoradiation Therapy Affects the Incidence of Anastomotic Leaks. (nih.gov)
- Delay in Oral Feeding is Associated With a Decrease in Anastomotic Leak Following Transhiatal Esophagectomy. (nih.gov)
- Role of Barium Swallow in Diagnosing Clinically Significant Anastomotic Leak following Esophagectomy. (semanticscholar.org)
- Do alterations in plasma albumin and prealbumin after minimally invasive esophagectomy for squamous cell carcinoma influence the incidence of cervical anastomotic leak? (semanticscholar.org)
- Analysis of cervical esophagogastric anastomotic leaks after transhiatal esophagectomy: risk factors, presentation, and detection. (semanticscholar.org)
- This arm contains subjects which will have NERv's Inline Device attached to their peritoneal drain after bariatric surgery (this includes: Roux-en-Y Gastric Bypass (RYGBP), Sleeve Gastrectomy (SG), Gastric Plication and Duodenal Switch). (clinicaltrials.gov)
- Our objective was to examine the relationship between technical factors and incidence of clinically relevant anastomotic leak after RYGB in longitudinal assessment of bariatric surgery (LABS). (elsevier.com)
- Background: The use of endoluminal stents has been proposed for the management of fistulas and anastomotic strictures after bariatric surgery. (elsevier.com)
- This is a new connection created in your intestines and stomach during the bypass surgery that will not fully heal and will leak. (hopkinsmedicine.org)
- Anastomotic leaks happen in 1.5% to 6% of bypass procedures, depending on the type of surgery. (hopkinsmedicine.org)
- This may be a small leak that can be managed conservatively or less commonly complete dehiscence requiring repeat surgery. (radiopaedia.org)
- Patients experiencing anastomotic leaks during and after bariatric and colorectal surgery have significantly higher costs and longer LOS both at the initial stay and within 30 days of the procedure. (springer.com)
- In fact, the CMS physician quality reporting system (PQRS) has included the reporting of anastomotic leak interventions that occur after colorectal and gastric bypass surgery. (springer.com)
- The median time interval from surgery to diagnosis of leak was 8 (IQR=2 to 14) weeks - only 5 leaks (10%) presented during the initial postoperative stay. (omicsonline.org)
- Conclusion: Procalcitonin is a reliable biochemical marker to help diagnose anastomotic leak in colorectal surgery. (physiciansweekly.com)
- In contrast, the standard recommended intravenous antibiotics used in patients undergoing colorectal surgery did not eliminate E. faecalis at anastomotic tissues nor did they prevent leak in our rat model. (igsb.org)
- Finally, we show in humans undergoing colon surgery and treated with the standard recommended intravenous antibiotics that their anastomotic tissues still contained E. faecalis and other bacterial strains with collagen-degrading/MMP9-activating activity. (igsb.org)
- Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. (rochester.edu)
- Platell C, Barwood N, Dorfmann G, Makin G (2006) The incidence of anastomotic leaks in patients undergoing colorectal surgery. (springer.com)
- We report a case of a very large anastomotic leak occurred after surgery for adenocarcinoma of the cardia, repaired with endoscopic insertion of an especially designed stent. (ijcrisurgery.com)
- Previous studies have suggested adverse outcomes after colorectal surgery in patients who are obese [ 5 ], increasing the rate of conversion, wound infection, cardiopulmonary disease, hospital stay, and anastomotic leak [ 6 ]. (omicsonline.org)
- In the control group, 1 patient suffered a postoperative anastomotic stricture requiring no surgery, and 1 patient suffered an anastomotic dehiscence requiring return to the operating room. (hindawi.com)
- As colorectal surgery evolves to incorporate the robotic platform, there is a need to study IcGA in this modality where haptic feedback and tactile sensation, critical to assessment of anastomotic integrity, are lacking. (hindawi.com)
- Can we predict anastomotic leak and ileus in patients undergoing colectomy? (facs.org)
- At the end of that two-week period, abdominal CT was performed, which did not reveal any abscesses near the leak site. (biomedcentral.com)
- Patients with anastomotic leaks usually present with abdominal pain, tachycardia, fever, distension and leukocytosis after the fifth postoperative day. (biomedcentral.com)
- Patients with early leaks or anastomotic strictures were excluded. (elsevier.com)
- The objective of our study was to determine the success of endoscopically placed, self-expandable metal stents (SEMS) in bariatric patients specifically with either chronic persistent anastomotic or staple line leaks/fistulas or chronic, persistent anastomotic strictures. (elsevier.com)
- Dilation of an anastomotic stricture in gastric bypass patients presents different challenges as compared with esophageal strictures. (medscape.com)
- Efficacy and Safety of the Over-the-Scope Clip (OTSC) System in the Management of Leak and Fistula After Laparoscopic Sleeve Gastrectomy: a Systematic Review. (ouhsc.edu)
- Patients with anastomotic leak are at increased risk of stricture and fistula formation. (rochester.edu)
- In last decade, endoscopic treatment options, such as stent placement, have been tried to repair these leaks with good outcomes. (ijcrisurgery.com)
- Temporary stent placement is an effective and reliable method to repair post surgical esophagogastric anastomotic leaks. (ijcrisurgery.com)
- Limits such as stent migration and size of the leaks can be overcome by the choice of the proper stent. (ijcrisurgery.com)
- The endoscopic management of a fully covered self -expandable metal stent (SEMS) has been suggested for the primary treatment of patients with anastomotic leaks after total gastrectomy . (bvsalud.org)
- The effectiveness and safety of endoscopic management were evaluated for anastomotic leaks when using a benign fully covered SEMS with an anchoring thread and thick silicone covering the membrane to prevent stent embedding and migration. (bvsalud.org)
- The technical success rate of endoscopic stent replacement was 100%, and the rate of complete leaks closure was 85.7% (n=12). (bvsalud.org)
- A benign fully covered SEMS with an anchoring thread and thick membrane is an effective and safe stent in patients with anastomotic leaks after total gastrectomy . (bvsalud.org)
- Use of a self-expandable metal stent (SEMS) as an initial intervention for leaks after laparoscopic sleeve gastrectomy (LSG) has increased. (nih.gov)
- This study aimed to determine predictors of anastomotic leak in elderly patients undergoing colectomy by creating a novel nomogram for simplistic prediction of anastomotic leak risk in a given patient. (ovid.com)
- Result: The rate of anastomotic leak was 4.5% (3 patients) with a mortality rate of 4.3% (3 patients). (physiciansweekly.com)
- We demonstrate that the commensal bacterium Enterococcus faecalis contributes to the pathogenesis of anastomotic leak through its capacity to degrade collagen and to activate tissue matrix metalloproteinase 9 (MMP9) in host intestinal tissues. (sciencemag.org)
- Either elimination of E. faecalis strains through direct topical antibiotics applied to rat intestinal tissues or pharmacological suppression of intestinal MMP9 activation prevented anastomotic leak in rats. (sciencemag.org)
- We suggest that intestinal microbes with the capacity to produce collagenases and to activate host metalloproteinase MMP9 may break down collagen in the intestinal tissue contributing to anastomotic leak. (igsb.org)
- Barium swallow showed free fluid in different esophageal parts with peri-anastomotic thin fistulous tract directed into the left lower intrathoracic pleura (Figure 1). (ispub.com)
- NERv's phase I clinical trial is a first-in-human, multi-center, pre-market, non-randomized, prospective clinical trial intended to evaluate the safety and collect preliminary data necessary for the detection of clinical post-operative anastomotic/intraperitoneal leakages. (clinicaltrials.gov)
- An anastomotic leak was treated conservatively at first for a total of three weeks. (biomedcentral.com)
- Contained leaks ( limited to the mediastinum ) are managed conservatively with antibiotics, nasogastric tube placement , TPN, and percutaneous drainage , if necessary. (rochester.edu)
- It may help a clinician decide to perform a CT scan even earlier especially when the diagnosis of a leak is uncertain. (physiciansweekly.com)
- Decreasing anastomotic and staple line leaks after laparoscopic Roux-en-Y gastric bypass. (howard.edu)
- The leak was treated successfully with endoscopic application of n -butyl-2-cyanoacrylate. (biomedcentral.com)
- This is the first case report on the endoscopic application of cyanoacrylate alone for the treatment of an anastomotic leak. (biomedcentral.com)
- The endoscopic application of several tissue adhesives, such as Human Fibrin Glue can seal the anastomotic leak site. (biomedcentral.com)
- The aim of our study is to present the case of an esophagojejunal anastomotic leak that was treated successfully with the topical endoscopic application of n -butyl-2-cyanoacrylate. (biomedcentral.com)
- therefore, the decision was made to apply endoscopic n -butyl-2-cyanoacrylate (Histoacryl) on the anastomotic leak site. (biomedcentral.com)
- I had to go back to hospital at Aintree for an operation to reverse a colostomy which went wrong and there was a leak in the valve and I had an infection. (thefreedictionary.com)
- In a database review of patients in Michigan who underwent colectomy, the study aimed to determine risk factors in diabetic patients that are associated with increased postcolectomy mortality and anastomotic leak. (emorysurgicalfocus.com)
- If the leak occurs early in the postoperative phase or the suspicion of a significant leak arises, then reoperation, peritoneal lavage and possible patching and/or resuturing may be possible. (biomedcentral.com)
- The Impact of Staple Line Reinforcement Utilization on Bleeding and Leak Rates Following Sleeve Gastrectomy for Severe Obesity: a Propensity and Case-Control Matched Analysis. (mayoclinic.org)
- 14. Example: Increased Leaks in RNY Revisions 8 leaks (0.95%) after RNY 5 leaks (4.20%) after Revision Revision 4 X Leak Rate Surg Obes Relat Dis. (slideshare.net)
- The serum CRP level on POD 3, 4 and 5 had comparable diagnostic accuracy for the development of an anastomotic leak with a pooled area under the curve of 0·81 (95 per cent confidence interval 0·75 to 0·86), 0·80 (0·74 to 0·86) and 0·80 (0·73 to 0·87) respectively. (bjs.co.uk)
- The use of barium is contraindicated because if there a leak and spill of barium into the peritoneal cavity it can cause a chronic chemical peritonitis . (radiopaedia.org)
- Laparoscopic Roux-en-Y gastric bypass. (medscape.com)
- As the minimally invasive approach progresses from laparoscopic to robotic approach, the effect and safety of IcGA in assessing anastomotic perfusion in the latter deserve further investigation. (hindawi.com)
- Initially, we attempted conservative management of the leak, namely, antibiotics, food deprivation and total parenteral nutrition for a period of two weeks. (biomedcentral.com)
- Are oral antibiotics combined with mechanical bowel preparation associated with a reduced risk of anastomotic leak? (news-medical.net)
- This case report describes an esophagojejunal anastomotic leak following total gastrectomy for gastric cancer. (biomedcentral.com)
- We retrospectively reviewed the data of 14 consecutive patients with gastric cancer and anastomotic leaks after total gastrectomy treated from January 2009 to December 2016. (bvsalud.org)
- She was in her usual state of health until two months back when she underwent in another hospital Roux-en-Y bypass gastrectomy for treatment of morbid obesity. (ispub.com)
- Makanyengo SO, Carroll GM, Goggins BJ, Smith SR, Pockney PG, Keely S, 'Systematic Review on the Influence of Tissue Oxygenation on Gut Microbiota and Anastomotic Healing. (edu.au)