Anaplasma: A genus of gram-negative bacteria whose organisms are obligate parasites of vertebrates. Species are transmitted by arthropod vectors with the host range limited to ruminants. Anaplasma marginale is the most pathogenic species and is the causative agent of severe bovine anaplasmosis.Anaplasma phagocytophilum: A species of gram-negative bacteria in the genus ANAPLASMA, family ANAPLASMATACEAE, formerly called Ehrlichia phagocytophila or Ehrlichia equi. This organism is tick-borne (IXODES) and causes disease in horses and sheep. In humans, it causes human granulocytic EHRLICHIOSIS.Anaplasma marginale: A species of gram-negative bacteria and causative agent of severe bovine ANAPLASMOSIS. It is the most pathogenic of the ANAPLASMA species.Anaplasmosis: A disease of cattle caused by parasitization of the red blood cells by bacteria of the genus ANAPLASMA.Ehrlichiosis: A tick-borne disease characterized by FEVER; HEADACHE; myalgias; ANOREXIA; and occasionally RASH. It is caused by several bacterial species and can produce disease in DOGS; CATTLE; SHEEP; GOATS; HORSES; and humans. The primary species causing human disease are EHRLICHIA CHAFFEENSIS; ANAPLASMA PHAGOCYTOPHILUM; and Ehrlichia ewingii.Anaplasma centrale: A species of gram-negative bacteria causing mild ANAPLASMOSIS in CATTLE. It also can infect SHEEP and GOATS. It is transmitted by TICKS.Anaplasma ovis: A species of gram-negative bacteria producing mild to severe ANAPLASMOSIS in SHEEP and GOATS, and mild or inapparent infections in DEER and CATTLE.Ixodes: The largest genus of TICKS in the family IXODIDAE, containing over 200 species. Many infest humans and other mammals and several are vectors of diseases such as LYME DISEASE, tick-borne encephalitis (ENCEPHALITIS, TICK-BORNE), and KYASANUR FOREST DISEASE.Ticks: Blood-sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (ARGASIDAE) and hardbacked ticks (IXODIDAE). Ticks are larger than their relatives, the MITES. They penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood. Ticks attack all groups of terrestrial vertebrates. In humans they are responsible for many TICK-BORNE DISEASES, including the transmission of ROCKY MOUNTAIN SPOTTED FEVER; TULAREMIA; BABESIOSIS; AFRICAN SWINE FEVER; and RELAPSING FEVER. (From Barnes, Invertebrate Zoology, 5th ed, pp543-44)Dermacentor: A widely distributed genus of TICKS, in the family IXODIDAE, including a number that infest humans and other mammals. Several are vectors of diseases such as TULAREMIA; ROCKY MOUNTAIN SPOTTED FEVER; COLORADO TICK FEVER; and ANAPLASMOSIS.Tick-Borne Diseases: Bacterial, viral, or parasitic diseases transmitted to humans and animals by the bite of infected ticks. The families Ixodidae and Argasidae contain many bloodsucking species that are important pests of man and domestic birds and mammals and probably exceed all other arthropods in the number and variety of disease agents they transmit. Many of the tick-borne diseases are zoonotic.Anaplasmataceae Infections: Infections with bacteria of the family ANAPLASMATACEAE.Tick Infestations: Infestations with soft-bodied (Argasidae) or hard-bodied (Ixodidae) ticks.Arachnid Vectors: Members of the class Arachnida, especially SPIDERS; SCORPIONS; MITES; and TICKS; which transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.Anaplasmataceae: A family of bacteria which inhabit RED BLOOD CELLS and cause several animal diseases.Ehrlichia: Small, often pleomorphic, coccoid to ellipsoidal organisms occurring intracytoplasmically in circulating LYMPHOCYTES. They are the etiologic agents of tick-borne diseases of humans; DOGS; CATTLE; SHEEP; GOATS; and HORSES.Babesia microti: A species of protozoa infecting humans via the intermediate tick vector IXODES scapularis. The other hosts are the mouse PEROMYSCUS leucopus and meadow vole MICROTUS pennsylvanicus, which are fed on by the tick. Other primates can be experimentally infected with Babesia microti.Cattle Diseases: Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.Bacterial Outer Membrane Proteins: Proteins isolated from the outer membrane of Gram-negative bacteria.Deer: The family Cervidae of 17 genera and 45 species occurring nearly throughout North America, South America, and Eurasia, on most associated continental islands, and in northern Africa. Wild populations of deer have been established through introduction by people in Cuba, New Guinea, Australia, New Zealand, and other places where the family does not naturally occur. They are slim, long-legged and best characterized by the presence of antlers. Their habitat is forests, swamps, brush country, deserts, and arctic tundra. They are usually good swimmers; some migrate seasonally. (Walker's Mammals of the World, 5th ed, p1362)Arthropod Vectors: Arthropods, other than insects and arachnids, which transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.Babesia: A genus of tick-borne protozoan parasites that infests the red blood cells of mammals, including humans. There are many recognized species, and the distribution is world-wide.Nymph: The immature stage in the life cycle of those orders of insects characterized by gradual metamorphosis, in which the young resemble the imago in general form of body, including compound eyes and external wings; also the 8-legged stage of mites and ticks that follows the first moult.Ehrlichia chaffeensis: A species of gram-negative bacteria that is the causative agent of human EHRLICHIOSIS. This organism was first discovered at Fort Chaffee, Arkansas, when blood samples from suspected human ehrlichiosis patients were studied.Babesiosis: A group of tick-borne diseases of mammals including ZOONOSES in humans. They are caused by protozoa of the genus BABESIA, which parasitize erythrocytes, producing hemolysis. In the U.S., the organism's natural host is mice and transmission is by the deer tick IXODES SCAPULARIS.Disease Reservoirs: Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.HL-60 Cells: A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Borrelia burgdorferi: A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.Neorickettsia: Genus of gram-negative, intracytoplasmic bacteria that are found primarily in VACUOLES of MONOCYTES in the BLOOD and MACROPHAGES of lymphoid or other tissues of DOGS; HORSES, and humans. (From Int. J. Syst. Evol. Microbiol. (2001) 51:2145-2165)Ixodidae: A family of hardbacked TICKS, in the subclass ACARI. Genera include DERMACENTOR and IXODES among others.RNA, Ribosomal, 16S: Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Ehrlichia ruminantium: A species of gram-negative bacteria in the family ANAPLASMATACEAE, that causes HEARTWATER DISEASE in ruminants.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Ehrlichia canis: Species of gram-negative bacteria in the family ANAPLASMATACEAE, causing EHRLICHIOSIS in DOGS. The most common vector is the brown dog tick. It can also cause disease in humans.Sheep Diseases: Diseases of domestic and mountain sheep of the genus Ovis.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Goat Diseases: Diseases of the domestic or wild goat of the genus Capra.SicilyRhipicephalus: A genus of TICKS, in the family IXODIDAE, widespread in Africa. Members of the genus include many important vectors of animal and human pathogens.Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Rickettsia: A genus of gram-negative, aerobic, rod-shaped bacteria often surrounded by a protein microcapsular layer and slime layer. The natural cycle of its organisms generally involves a vertebrate and an invertebrate host. Species of the genus are the etiological agents of human diseases, such as typhus.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.PolandSeroepidemiologic Studies: EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.Antigenic Variation: Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)Grenada: An island of the West Indies. Its capital is St. George's. It was discovered in 1498 by Columbus who called it Concepcion. It was held at different times by the French and the British during the 18th century. The British suppressed a native uprising in 1795. It was an associate state of Great Britain 1967-74 but became an independent nation within the British Commonwealth in 1974. The original name referred to the Feast of the Immaculate Conception but it was later renamed for the Spanish kingdom of Granada. (From Webster's New Geographical Dictionary, 1988, p467 & Room, Brewer's Dictionary of Names, 1992, p219)Borrelia: A genus of gram-negative, anaerobic, helical bacteria, various species of which produce RELAPSING FEVER in humans and other animals.Lyme Disease: An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.Rickettsiaceae: A family of small, gram-negative organisms, often parasitic in humans and other animals, causing diseases that may be transmitted by invertebrate vectors.Bacterial Proteins: Proteins found in any species of bacterium.Parasitic Diseases, Animal: Infections or infestations with parasitic organisms. The infestation may be experimental or veterinary.Horse Diseases: Diseases of domestic and wild horses of the species Equus caballus.Animals, Wild: Animals considered to be wild or feral or not adapted for domestic use. It does not include wild animals in zoos for which ANIMALS, ZOO is available.Bacterial Vaccines: Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.Horses: Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Goats: Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.Theileria: A genus of tick-borne protozoa parasitic in the lymphocytes, erythrocytes, and endothelial cells of mammals. Its organisms multiply asexually and then invade erythrocytes, where they undergo no further reproduction until ingested by a transmitting tick.Theileriasis: Infection of cattle, sheep, or goats with protozoa of the genus THEILERIA. This infection results in an acute or chronic febrile condition.Citrate (si)-Synthase: Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7.

Restriction of major surface protein 2 (MSP2) variants during tick transmission of the ehrlichia Anaplasma marginale. (1/149)

Anaplasma marginale is an ehrlichial pathogen of cattle that establishes lifelong persistent infection. Persistence is characterized by rickettsemic cycles in which new A. marginale variant types, defined by the sequence of the expressed msp2 transcripts, emerge. The polymorphic msp2 transcripts encode structurally distinct MSP2 proteins and result in an antigenically diverse and continually changing A. marginale population within the blood. In this manuscript, we used sequence analysis of msp2 transcripts to show that a restricted repertoire of variant types, designated SGV1 and SGV2, is expressed within the tick salivary gland. The same SGV1 and SGV2 variant types were expressed in ticks regardless of the variant types expressed in the blood of infected cattle at the time of acquisition feeding by the ticks. Importantly, subsequent tick transmission to susceptible cattle resulted in acute rickettsemia composed of organisms expressing only the same SGV1 and SGV2 variant types. This indicates that the msp2 expressed by organisms within the tick salivary gland predicts the variant type responsible for acute rickettsemia and disease. This restriction of transmitted A. marginale variant types, in contrast to the marked diversity within persistently infected cattle, supports development of MSP2 vaccines to prevent acute rickettsemia in tick-transmitted infections.  (+info)

Biased immunoglobulin G1 isotype responses induced in cattle with DNA expressing msp1a of Anaplasma marginale. (2/149)

Immunization with the native major surface protein 1 (MSP1) (a heterodimer containing disulfide and noncovalently bonded polypeptides designated MSP1a and MSP1b) of the erythrocytic stage of Anaplasma marginale conferred protection against homologous challenge (G. H. Palmer, A. F. Barbet, W. C. Davis, and T. C. McGuire, Science 231:1299-1302, 1986). The MSP1a polypeptide possesses a conserved neutralization-sensitive epitope. In the present study, the immune response to DNA-mediated immunization using msp1a was studied. The plasmid pVCL/MSP1a, which encodes the complete msp1a gene of A. marginale under the control of human cytomegalovirus immediate-early enhancer/promoter and intron A, was constructed. The immune responses elicited by immunization with pVCL/MSP1a into cardiotoxin-induced regenerating muscle were evaluated in mice and cattle. Antibody reactive with native MSP1a was detected in pooled sera of immunized BALB/c mice 3 weeks following primary immunization. Two calves seronegative for A. marginale were immunized four times, at weeks 0, 3, 7, and 13, with pVCL/MSP1a. By 8 weeks, both calves responded to MSP1a with an antibody titer of 1:100, which peaked at 1:1,600 and 1:800 by 16 weeks after the initial immunization. Interestingly, immunoblotting with anti-immunoglobulin G1 (anti-IgG1) and anti-IgG2 specific monoclonal antibodies revealed a restricted IgG1 anti-MSP1a response in both animals. T-lymphocyte lines, established after the fourth immunization, proliferated specifically against A. marginale homogenate and purified MSP1 in a dose-dependent manner. These data provide a basis for an immunization strategy to direct bovine immune responses by using DNA vaccine vectors containing single or multiple genes encoding major surface proteins of A. marginale.  (+info)

Emergence of Anaplasma marginale antigenic variants during persistent rickettsemia. (3/149)

Anaplasma marginale is an ehrlichial pathogen of cattle, in the order Rickettsiales, that establishes persistent cyclic rickettsemia in the infected host. Within each rickettsemic cycle, A. marginale expressing antigenically variant major surface protein 2 (MSP2) emerge. By cloning 17 full-length msp2 transcripts expressed during cyclic rickettsemia, we determined that emergent variants have a single, central hypervariable region encoding variant B-cell epitopes. The N- and C-terminal regions are highly conserved among the expressed A. marginale variants, and similar sequences define the MSP2 homologues in the agent of human granulocytic ehrlichiosis (HGE). This is in contrast to the MSP2 homologues in ehrlichial genogroup I pathogens, Ehrlichia chaffeensis, Ehrlichia canis, and Cowdria ruminantium, that have multiple hypervariable regions. By defining the variable and conserved regions, we were able to show that the single hypervariable region of A. marginale MSP2 encodes epitopes that are immunogenic and induce variant-specific antibody responses during persistent infection. These findings demonstrate that the MSP2 structural variants that emerge during each cycle of persistent rickettsemia are true antigenic variants, consistent with MSP2 antigenic variation as a mechanism of A. marginale persistence.  (+info)

Interleukin-12 as an adjuvant promotes immunoglobulin G and type 1 cytokine recall responses to major surface protein 2 of the ehrlichial pathogen Anaplasma marginale. (4/149)

Anaplasma marginale is a tick-transmitted pathogen of cattle closely related to the human ehrlichiae, Ehrlichia chaffeensis and the agent of human granulocytic ehrlichiosis (HGE). These pathogens have in common a structurally conserved outer membrane protein (OMP) designated the major surface protein 2 (MSP-2) in A. marginale and HGE and OMP-1 in E. chaffeensis. Protective immunity against ehrlichial pathogens is believed to require induction of gamma interferon (IFN-gamma) and opsonizing immunoglobulin (Ig) subclasses directed against OMP epitopes that, in concert, activate macrophages for phagocytosis and killing. Because interleukin-12 (IL-12) acts as an adjuvant for protein immunization to induce IFN-gamma and protective immunity against intracellular pathogens, we hypothesized that as an adjuvant with MSP-2, IL-12 would augment type 1 recall responses to A. marginale. IL-12 was coadsorbed with MSP-2 to alum and shown to significantly enhance IFN-gamma production by lymph node cells (LNC) and LNC-derived CD4(+) T-cell lines from immunized calves following recall stimulation with A. marginale. LNC proliferation and IL-2 production were also enhanced in IL-12-treated calves. Elevated recall proliferative responses by peripheral blood mononuclear cells were still evident 9 months after immunization. Serum IgG levels were consistently increased in IL-12 immunized calves, predominantly due to higher IgG1 responses. The results support the use of IL-12 coadsorbed with OMP of ehrlichial pathogens in alum to amplify both antibody and type-1 cytokine responses important for protective immunity.  (+info)

Expression of polymorphic msp1beta genes during acute anaplasma Marginale rickettsemia. (5/149)

Immunization of cattle with native MSP1 induces protection against Anaplasma marginale. The native immunogen is composed of a single MSP1a protein and multiple, undefined MSP1b polypeptides. In addition to the originally sequenced gene, designated msp1beta(F1), we identified three complete msp1beta genes in the Florida strain: msp1beta(F2), msp1beta(F3), and msp1beta(F4). Each of these polymorphic genes encodes a structurally unique MSP1b protein, and unique transcripts can be identified during acute A. marginale rickettsemia. The structural polymorphism is clustered in discrete variable regions, and each MSP1b protein results from a unique mosaic of five variable regions. Although each of the MSP1b proteins in the Florida strain contains epitopes recognized by serum antibody induced by protective immunization with the native MSP1 complex, the variable regions also include epitopes expressed by some but not all of the MSP1b proteins. These data support testing recombinant vaccines composed of the multiple antigenically and structurally unique MSP1b proteins combined with MSP1a in order to mimic the efficacy of native MSP1 immunization.  (+info)

Strain diversity in major surface protein 2 expression during tick transmission of Anaplasma marginale. (6/149)

Specific major surface protein 2 (MSP2) variants are expressed by Anaplasma marginale within the tick salivary gland and, following transmission, are expressed during acute rickettsemia. In previous work, we have shown that a restricted pattern of MSP2 variants is expressed in the salivary glands of Dermacentor andersoni ticks infected with the South Idaho strain of A. marginale. Now we demonstrate that the identical restriction does not apply to two other strains of A. marginale, and that different variants are also expressed when the same strain is transmitted by different Dermacentor spp. This indicates that antigenic diversity among strains is maintained in tick transmission and may be a significant constraint to MSP2 vaccine development.  (+info)

Antigenic variation in vector-borne pathogens. (7/149)

Several pathogens of humans and domestic animals depend on hematophagous arthropods to transmit them from one vertebrate reservoir host to another and maintain them in an environment. These pathogens use antigenic variation to prolong their circulation in the blood and thus increase the likelihood of transmission. By convergent evolution, bacterial and protozoal vector-borne pathogens have acquired similar genetic mechanisms for successful antigenic variation. Borrelia spp. and Anaplasma marginale (among bacteria) and African trypanosomes, Plasmodium falciparum, and Babesia bovis (among parasites) are examples of pathogens using these mechanisms. Antigenic variation poses a challenge in the development of vaccines against vector-borne pathogens.  (+info)

Antigenic variation of Anaplasma marginale by expression of MSP2 mosaics. (8/149)

Anaplasma marginale is a tick-borne pathogen, one of several closely related ehrlichial organisms that cause disease in animals and humans. These Ehrlichia species have complex life cycles that require, in addition to replication and development within the tick vector, evasion of the immune system in order to persist in the mammalian reservoir host. This complexity requires efficient use of the small ehrlichial genome. A. marginale and related ehrlichiae express immunoprotective, variable outer membrane proteins that have similar structures and are encoded by polymorphic multigene families. We show here that the major outer membrane protein of A. marginale, MSP2, is encoded on a polycistronic mRNA. The genomic expression site for this mRNA is polymorphic and encodes numerous amino acid sequence variants in bloodstream populations of A. marginale. A potential mechanism for persistence is segmental gene conversion of the expression site to link hypervariable msp2 sequences to the promoter and polycistron.  (+info)

*Dermacentor

Anaplasma marginale, which causes anaplasmosis in cattle, Francisella tularensis, which causes tularemia, Babesia caballi, ...

*Ticks of domestic animals

Anaplasma centrale tends to infect the central region of red blood cells, and is sufficiently closely related to An. marginale ... Anaplasma marginale infects marginal areas of red blood cells of cattle and causes anaplasmosis wherever boophilid ticks occur ... Anaplasma phagocytophilum (formerly Ehrlichia phagocytophila) is a bacterium of deer that spreads to sheep where it causes tick ... However, some microbes, such as Anaplasma marginale and A. centrale, can also be transmitted by biting flies, or by blood on ...

*Dermacentor variabilis

... may also carry Anaplasma phagocytophilum, the causative agent of HGE (human granulocytic ehrlichiosis), ... and Anaplasma phagocytophilum in Ticks (Acari: Ixodidae) from a Coastal Region of California". J. Med. Entomol. 40 (4): 534-9. ...

*Ehrlichia chaffeensis

Baneth, G. (2010). Ehrlichia and anaplasma infections. Paper presented at World small animal veterinary congress. Retrieved ...

*Anaplasma

... marginale and Anaplasma centrale in cattle Anaplasma mesaeterum and Anaplasma ovis in sheep and goats Anaplasma ... Anaplasma phagocytophilum Anaplasma platys Anaplasmosis Parte, A.C. "Anaplasma". www.bacterio.net. Anaplasmas reviewed and ... Anaplasma genomes in the JGI genome browser Anaplasma at the US National Library of Medicine Medical Subject Headings (MeSH) ... Anaplasma Genome Projects (from Genomes OnLine Database) Comparative Analysis of Anaplasma Genomes (at DOE's IMG system). ...

*Anaplasma phagocytophilum

... HZ Genome Page Anaplasma phagocytophilum at the US National Library of Medicine Medical Subject ... Anaplasma phagocytophilum is a small, obligate, intracellular bacterium with a Gram-negative cell wall. It is 0.2-1.0 μm and ... Page Anaplasma on bacterio.net Dumler JS, Barbet AF, Bekker CP, et al. (2001). "Reorganization of genera in the families ... Anaplasma phagocytophilum (formerly Ehrlichia phagocytophilum) is a gram-negative bacterium that is unusual in its tropism to ...

*Anaplasma bovis

... (formerly Ehrlichia bovis) is a gram-negative bacterium. Dumler JS, Barbet AF, Bekker CP, et al. (2001). " ... unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions ...

*Canine vector-borne disease

Anaplasma phagocytophilum causes granulocytic anaplasmosis. Borrelia burgdorferi causes Lyme disease. Rickettsia rickettsii ...

*Human monocytotropic ehrlichiosis

December 2005). "Human granulocytic anaplasmosis and Anaplasma phagocytophilum". Emerging Infectious Diseases. 11 (12): 1828-34 ... and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California". J. Med. Entomol. 40 (4): 534-9. ...

*Human granulocytic anaplasmosis

Lots of MSPs are found in Anaplasma and the ones that interact with Anaplasma can mainly be found in A. marginale and A. ... Anaplasma phagocytophilum shares its tick vector with other human pathogens, and about 10% of patients with HGA show serologic ... Anaplasma MSPs can not only cooperate with vertebrates, but also invertebrates, which make these phenotypes evolve faster than ... Although the infectious agent is known to be from the Anaplasma genus, the term "human granulocytic ehrlichiosis" (HGE) is ...

*Anaplasmosis

Anaplasma centrale - found mainly in South America, Africa and the Middle East. Sheep and goats: Anaplasma ovis - found ... In 2005, Anaplasma ovis was found in reindeer populations in Mongolia. This pathogen and its associated syndrome (characterized ... In Australia, bovine anaplasmosis, caused by Anaplasma marginale, is only found in the northern and eastern parts of Australia ... Anaplasmosis is a disease caused by a rickettsial parasite of ruminants, Anaplasma spp. The microorganism is gram-negative, and ...

*Mabel Josephine Mackerras

136). Mackerras, I. M., Mackerras, M. J., & Mulhearn, C. R. (1942). Attempted transmission of Anaplasma marginale Theiler by ...

*Haemaphysalis leporispalustris

Strains of Anaplasma bovis have also been found in rabbit ticks, which was discovered in a Nantucket tick study of the bacteria ... Goethert, H.K.; S.R. Telford III (2003). "Enzootic Transmission of Anaplasma bovis in Nantucket Cottontail Rabbits". Journal of ...

*Rickettsia akari

21: Rickettsia, Orientia, Ehrlichia, Anaplasma, Coxiella and Bartonella". Microbiology and Immunology On-line. University of ...

*Secretion

T4SS has two effector proteins: firstly, ATS-1, which stands for Anaplasma translocated substrate 1, and secondly AnkA, which ... Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum". Cellular Microbiology. 12 (9): 1213-21 ...

*Anaplasmataceae

... is a Proteobacteria family that includes genera Anaplasma, Ehrlichia, Neorickettsia and Wolbachia. Garrity, ...

*Ehrlichiosis ewingii infection

Like Anaplasma phagocytophilum, the causative agent of human granulocytic ehrlichiosis, Ehrlichia ewingii infects neutrophils. ...

*Ehrlichia

... and their closely related species Anaplasma show extreme diversity in the structure and content of their genomes. ... "Structural basis for segmental gene conversion in generation of Anaplasma marginale outer membrane protein variants". Molecular ...

*Ixodes ricinus

... and the bacterium Anaplasma marginale. Horses may be infected with Lyme disease, Anaplasma phagocytophila, and the viral ... Anaplasma phagocytophila), Q fever (Coxiella burnetii), Boutonneuse fever (Rickettsia conorii), ...

*Haemaphysalis longicornis

Mi-Jin Lee; Joon-Seok Chae (2010). "Molecular detection of Ehrlichia chaffeensis and Anaplasma bovis in the salivary glands ... Lyme spirochetes, spotted fever group rickettsiae , and Ehrlichia chaffeensis and Anaplasma bovishave been detected in H. ...

*SP110

2007). "Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells". ...

*Ehrlichia ewingii

It is also closely related to Wolbachia, Anaplasma, and Neorickettsia bacteria, with Rickettsia as a more distant genus. ... Lin, Mingqun; Rikihisa, Yasuko (2003-09-01). "Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A ... unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions ...

*Ehrlichiosis

Five (see note below) species have been shown to cause human infection: Anaplasma phagocytophilum (which causes human ... genera Ehrlichia and Anaplasma. These obligate intracellular bacteria infect and kill white blood cells. The average reported ...

*Rhipicephalus annulatus

It is a potential vector of many babesiosis pathogens like Babesia bigemina, Babesia bovis, and Anaplasma marginale. It shows a ...

*Nyala

The dominant parasites were Theileria species, T. buffeli, T. bicornis, Ehrlichia species, Anaplasma marginale and A. bovis. ...
En taxonomía, Anaplasma es un género de bacterias perteneciente al orden de los rickettsiales. Anaplasma bovis (Donatien and Lestoquard 1936) Dumler, Barbet, Bekker, Dasch, Palmer, Ray, Rikihisa & Rurangirwa 2001. Anaplasma caudatum (Kreier and Ristic 1963) Ristic & Kreier 1984. Anaplasma centrale (ex Theiler 1911) Ristic & Kreier 1984. Anaplasma marginale Theiler 1910. Anaplasma ovis Lestoquard 1924. Anaplasma phagocytophilum (Foggie 1951) Dumler, Barbet, Bekker, Dasch, Palmer, Ray, Rikihisa & Rurangirwa 2001. Anaplasma platys (French and Harvey 1983) Dumler, Barbet, Bekker, Dasch, Palmer, Ray, Rikihisa & Rurangirwa 2001. MeSH: Anaplasma (en inglés) Anaplasma Genome Projects (from Genomes OnLine Database) Comparative Analysis of Anaplasma Genomes (at DOEs IMG system ...
The genus Anaplasma (Rickettsiales: Anaplasmataceae) comprises obligate intracellular Gram-negative bacteria that are mainly transmitted by ticks, and currently includes six species: Anaplasma bovis, Anaplasma centrale, Anaplasma marginale, Anaplasma phagocytophilum, Anaplasma platys, and Anaplasma ovis. These have long been known as etiological agents of veterinary diseases that affect domestic and wild animals worldwide. A zoonotic role has been recognized for A. phagocytophilum, but other species can also be pathogenic for humans.
Anaplasma é um gênero de bactérias gram-negativas da família Anaplasmataceae. Anaplasma bovis (Donatien and Lestoquard 1936) Dumler, Barbet, Bekker, Dasch, Palmer, Ray, Rikihisa & Rurangirwa 2001 Anaplasma caudatum (Kreier and Ristic 1963) Ristic & Kreier 1984 Anaplasma centrale (ex Theiler 1911) Ristic & Kreier 1984 Anaplasma marginale Theiler 1910 Anaplasma ovis Lestoquard 1924 Anaplasma phagocytophilum (Foggie 1951) Dumler, Barbet, Bekker, Dasch, Palmer, Ray, Rikihisa & Rurangirwa 2001 Anaplasma platys (French and Harvey 1983) Dumler, Barbet, Bekker, Dasch, Palmer, Ray, Rikihisa & Rurangirwa 2001 GARRITY, G.M. (ed.). Bergeys Manual of Systematic Bacteriology - The Proteobacteria Part C. 2 ed. Nova Iorque: Springer, 2005 ...
Anaplasma species infection mimics many other conditions, including other chronic infections. If you are experiencing hard-to-diagnose chronic symptoms and have had a recent tick attachment or live in a region endemic for Anaplasma species in ticks, you should consider testing for Anaplasma infection. Symptoms can range from mild to serious illness characterized by fever, chills, headache, confusion, myalgia, nausea/vomiting/diarrhea, acute weight loss, abdominal pain, difficulty breathing, neurological problems and other conditions that may require immediate medical attention. This zoonotic infection is primarily transmitted to humans by Ixodes ticks, but can also be transmitted through blood transfusion. Clinical presentations may be more severe when co-infected with multiple tick-borne pathogens.. Tests Offered. Anaplasma species PCR test is designed to detect all pathogenic Anaplasma species. Positive results are confirmed by DNA sequencing to identify the infecting species. It is ...
We investigated the reservoir role of European wild rodents for Anaplasma phagocytophila using polymerase chain reaction (PCR) analysis of blood collected from individually tagged rodents captured monthly over 2 years. The only tick species observed in the woodland study site was Ixodes trianguliceps, and ruminant reservoir hosts were not known to occur. A. phagocytophila infections were detected in both bank voles and wood mice but were restricted to periods of peak nymphal and adult tick activity. Most PCR-positive rodents were positive only once, suggesting that rodent infections are generally short-lived and that ticks rather than rodents may maintain the infection over winter. Bank voles were more likely to be PCR positive than wood mice, possibly because detectable infections are longer lived in bank voles. This study confirms that woodland rodents can maintain A. phagocytophila in Great Britain in the absence of other reservoir hosts and suggests that I. trianguliceps is a competent vector.
Anaplasma spp. are widely spread rickettsial bacteria transmitted by ticks and placing high impacts on veterinary and public health. A limited number of studies have been carried out on Anaplasmosis in the central part of Iraq. This study was conducted to determine the presence of Anaplasma spp. in cattle in Al-Qadisiyah province, Iraq. A total of 400 blood specimens were collected from cattle suffering from heavy tick infestation. Cattle were blood-sampled from four hyper-endemic areas with ticks. Blood samples were screened using microscopic and polymerase chain reaction (PCR) methods. Diff-quick stained blood smears revealed Anaplasma-like inclusion bodies in 254 (63.5%) samples. According to the 16S rRNA-gene-based PCR analysis, Anaplasma spp. was detected in 124 of the 400 (31%) samples, divided as 96/254 (37.8%) among the microscopical positive samples and 28/146 (19.17%) among the microscopical negative samples. Phylogenetic analysis based on the partial 16S rRNA gene sequencing of ...
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Clinical assay intended to detect the presence of Babesia and Anaplasma species in whole blood specimens.. If screening test is positive or equivocal, the test will automatically be referred for "Lyme Disease Antibody, Confirmation, Serum" testing at an additional charge ...
Classification of bacteria is challenging due to the lack of a theory-based framework. In addition, the adaptation of bacteria to ecological niches often results in selection of strains with diverse virulence, pathogenicity and transmission characteristics. Bacterial strain diversity presents challenges for taxonomic classification, which in turn impacts the ability to develop accurate diagnostics and effective vaccines. Over the past decade, the worldwide diversity of Anaplasma marginale, an economically important tick-borne pathogen of cattle, has become apparent. The extent of A. marginale strain diversity, formerly underappreciated, has contributed to the challenges of classification which, in turn, likely impacts the design and development of improved vaccines. Notably, the A. marginale surface protein 1a (MSP1a) is a model molecule for these studies because it serves as a marker for strain identity, is both an adhesin necessary for infection of cells and an immuno-reactive protein and is ...
Introduction. Canine monocytic ehrlichiosis (CME) and canine thrombocytic anaplasmosis (CTA) are infectious diseases caused by gram-negative bacteria of the Order Rickettsiales, family Anaplasmataceae, genera Ehrlichia and Anaplasma (DUMLER et al., 2001). Ehrlichia canis and Anaplasma platys are obligatorily intracellular organisms organized in clusters, called morulae, and frequently observed in leukocytes and platelets, respectively, with the possibility of concomitant infections (McBRIDE et al., 1996; COHN, 2003; SUKSAWAT et al., 2001a). These infectious diseases are of great importance for small animal clinics and public health, since they are increasingly prevalent in dogs and because there is evidence that these pathogens can also affect humans (DAGNONE et al., 2001; TAMÍ; TAMÍ-MAURY, 2004; NEER; HARRUS, 2006).. The transmission of E. canis occurs primarily through the bite of the tick, Rhipicephalus sanguineus, and this tick might be associated with the transmission of A. platys to dogs ...
TY - JOUR. T1 - Prevalence of human-Active and variant 1 strains of the tick-borne pathogen Anaplasma phagocytophilum in hosts and forests of Eastern North America. AU - Keesing, Felicia. AU - McHenry, Diana J.. AU - Hersh, Michelle. AU - Tibbetts, Michael. AU - Brunner, Jesse L.. AU - Killilea, Mary. AU - LoGiudice, Kathleen. AU - Schmidt, Kenneth A.. AU - Ostfeld, Richard S.. PY - 2014. Y1 - 2014. N2 - Anaplasmosis is an emerging infectious disease caused by infection with the bacterium Anaplasma phagocytophilum. In the eastern United States, A. phagocytophilum is transmitted to hosts through the bite of the blacklegged tick, Ixodes scapularis. We determined the realized reservoir competence of 14 species of common vertebrate hosts for ticks by establishing the probability that each species transmits two important strains of A. phagocytophilum (A. phagocytophilum human-Active, which causes human cases, and A. phagocytophilum variant 1, which does not) to feeding larval ticks. We also sampled ...
In situ hybridization (ISH), which allows localization of pathogen nucleic acid in tissue sections, was used to detect A. marginale, a rickettsial pathogen of cattle, in its tick vector. Dermacentor andersoni males were experimentally infected with A. marginale, and one-half of each of 20 ticks was embedded in paraffin or LR White for ISH: companion halves were embedded in DER resin for light microscopy. Sections were digested with proteinase K and hybridized with a digoxigenin-labelled DNA probe. In both paraffin and LR White embedded sections, dark-blue colour precipitates of hybridization signals were visualized in both salivary gland and gut cells. Anaplasma infections were also confirmed by light microscopy in companion tick halves. Positive hybridization signals and A. marginale colonies were not seen in uninfected control tissues. Although ISH detected A. marginale in both paraffin and LR White embedded sections, LR White was found to be optimum for ISH of A. marginale because of improved ...
Shared and unique antigens were identified and partially characterized for two morphologically and antigenically distinct isolates of Anaplasma, A. marginale (Florida) (FAM) and A. caudatum (Illinois) (IAC). Crude CA-like antigens were prepared from the parasitemic blood of each calf, separated by SDS-PAGE, electroblotted onto nitrocellulose, and detected using immune bovine sera and an avidin-biotin-peroxidase assay with biotinylated rabbit anti-goat IgG (cross-reacted with cattle, sheep and deer antibodies). IAC antigens were 200 kilodalton (kd), 100 kd, 96 kd, 75 kd, 47 kd, 43 to 38 kd, and 27 kd, detected using anti-IAC and anti-FAM sera. FAM antigens were 108 kd, 100 kd, 96 kd, 91 kd, 75 kd, 47 kd, 43 to 38 kd, and 27 kd, detected using anti-FAM sera and, except for the 91 kd, with anti-IAC sera. The 91 kd is an FAM isolate-specific antigen. The 108 kd, 100 kd, and 96 kd are group-specific antigens of A. marginale and A. centrale. The 43 to 38 kd is genus-specific. The 96, 91, and 75 kd ...
Heparinized whole blood, heavily parasitized with Anaplasma marginale, was collected from 3 splenectomized oxen. Buffered lactose peptone (BLP) was added in equal volumes as a stabilizer and the mixture lyophilized in 2 ml aliquots after rapid freezing. The dried material was reconstituted with 2 ml sterile water and inoculated without delay. The product remained infective for at least 6 months when stored in an ordinary household deep-freeze unit ...
BACKGROUND: Only a few studies have examined the presence of Anaplasma marginale and Anaplasma centrale in South Africa, and no studies have comprehensively examined these species across the whole country. To undertake this country-wide study we adapted a duplex quantitative real-time PCR (qPCR) assay for use in South Africa but found that one of the genes on which the assay was based was variable ...
24.BraytonKA,PalmerGH,BrownWC: Genomicandproteomicapproaches tovaccinecandidateidentificationfor Anaplasmamarginale ExpertRev Vaccines 2006, 5: 95 101. 25.PierleSA,DarkMJ,DahmenD,PalmerGH,BraytonKA: Comparative genomicsandtranscriptomicsoftrait-geneassociation. BMCGenomics 2012, 13: 669. 26.VanOpijnenT,CamilliA: Transposoninsertionsequencing:anewtoolfor systems-levelanalysisofmicroorganisms. NatRevMicrobiol 2013, 11: 435 442. 27.ClaeysBouuaertC,ChalmersRM: Genetherapyvectors:theprospectsand potentialsofthecut-and-pastetransposons. Genetica 2010, 138: 473 484. 28.PicardeauM: Transpositionofflymarinerelementsintobacteriaasa genetictoolformutagenesis. Genetica 2010, 138: 551 558. 29.LampeDJ,GrantTE,RobertsonHM: Factorsaffectingtranspositionofthe Himar1 marinertransposoninvitro. Genetics 1998, 149: 179 187. 30.PlasterkRH,IzsvakZ,IvicsZ: Residentaliens:theTc1/marinersuperfamily oftransposableelements. TrendsGenet 1999, 15: 326 332. 31.ClarkTR,EllisonDW,KlebaB,HackstadtT: Complementationof Rickettsia ...
Ubiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from the shikimate pathway; 4-hydroxybenzoate is directly formed from chorismate in bacteria, while it can be formed from either chorismate or tyrosine in yeast. The following biosynthesis of terpenoid moiety involves reactions of prenylation, decarboxylation, and three hydroxylations alternating with three methylations. The order of these reactions are somewhat different between bacteria and yeast. Phylloquinone (vitamin K1), menaquinone (vitamin K2), and tocopherol (vitamin E) are fat-soluble vitamins. Phylloquinone is a compound present in all photosynthetic plants serving as a cofactor for photosystem I-mediated electron transport. Menaquinone is an obligatory component of the electron-transfer pathway in bacteria ...
BLOT kit for the detection of specific IgG antibodies to the recombinant antigens of Anaplasma phagocytophilum (HGA) in human serum and plasma.
ID B9KHY5_ANAMF Unreviewed; 221 AA. AC B9KHY5; DT 24-MAR-2009, integrated into UniProtKB/TrEMBL. DT 24-MAR-2009, sequence version 1. DT 07-JUN-2017, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313,EMBL:ACM49097.1}; GN OrderedLocusNames=AMF_220 {ECO:0000313,EMBL:ACM49097.1}; OS Anaplasma marginale (strain Florida). OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; OC Anaplasmataceae; Anaplasma. OX NCBI_TaxID=320483 {ECO:0000313,EMBL:ACM49097.1, ECO:0000313,Proteomes:UP000007307}; RN [1] {ECO:0000313,EMBL:ACM49097.1, ECO:0000313,Proteomes:UP000007307} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Florida {ECO:0000313,EMBL:ACM49097.1, RC ECO:0000313,Proteomes:UP000007307}; RX PubMed=19134224; DOI=10.1186/1471-2164-10-16; RA Dark M.J., Herndon D.R., Kappmeyer L.S., Gonzales M.P., Nordeen E., RA Palmer G.H., Knowles D.P. Jr., Brayton K.A.; RT "Conservation in the face of diversity: multistrain analysis of an RT intracellular bacterium."; RL BMC ...
Lineage: cellular organisms; Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Anaplasmataceae; Anaplasma; Anaplasma ...
Lineage: cellular organisms; Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Anaplasmataceae; Anaplasma; Anaplasma ...
A population of approximately 2500 dogs inhabits the island of Santa Cruz in the Galápagos Islands and many of these dogs freely roam the streets of the island in close proximity to people. The dog population receives minimal, if any, veterinary care or ectoparasite prophylaxis, leaving the majority of the dogs at risk for vector-borne infections such as Anaplasma platys, Borrelia burgdorferi, Dir ...
(34) Grouped under this heading are chlamydia, mycoplasma and other bacteria generally. Chlamydia These and anaplasma used to be classified separately from bacteria but are now...
I have a 20g with 3 platys and a BN. Recently I bought some live plants from Petco. They came with snails and within 3 days I had 2 dead female platys with what
There has been no agreement reached between Canada and Chinese government officials regarding China's intention to implement phytosanitary certificates on all imported canola after Nov. 15, an official with the Canola Council of Canada said.
2002) Erratum to "A msp1α polymerase chain reaction assay for specific detection and differentiation of Anaplasma marginale isolates" [Vet. Microbiol. 86 (2002) 325-335]. Veterinary Microbiology, 87 (4). pp. 365-366. ...
Anaplasma marginale is the most prevalent tick-borne pathogen of cattle. It is transmitted by ixodid ticks. Symptoms of acute disease are anemia, weight loss, and often death. A.marginale establishes life-long persistent infection in animals that survive disease. These animals are clinically healthy but serve as reservoirs for transmission of the pathogen. Anaplasma marginale subsp. centrale (Anaplasma centrale (strain Israel)) is a naturally occurring attenuated strain has been used as a live vaccine to prevent severe disease due to A. marginale senso stricto strains for 100 years. A. marginale subsp. centrale contains 10 putative genes not found in the genomes of senso stricto strains, while 18 genes found in senso stricto strains are absent from A. marginale subsp. centrale. As inoculation with purified outer membrane protein (OMP) complexes provides immunity against A. marginale, it is important to identify OMPs that differ among A,marginale to identify further vaccine candidates. ...
Clinical. Epidemiological elements + Clinical signs. Laboratory. Direct. Using light microscopy on peripheral stained blood smears, the diagnosis relies on the observation of a typical morula of Anaplasma platys in the platelets for thrombocytic anaplasmosis and the observation of a typical morula of Anaplasma phagocytophilum in the neutrophils for granulocytic anaplasmosis.. Infection is confirmed by PCR detection of bacterial DNA on tissues or blood.. Indirect. Indirect fluorescent antibody (IFA) assays to determine serum antibody against Anaplasma spp. available in veterinary laboratories.. Fast diagnosis at patient-side, based on an multivalent enzyme-linked immunosorbent assay (ELISA) is available for the detection of antibodies to E. canis, E. ewingii, A. phagocytophilum and A. platys.. Differential. Other tick-borne pathogens: Ehrlichia spp., Borrelia spp., Rickettsia spp.. Co-infection with other vector-borne pathogens is reported, especially co-infection with B. burgdorferi and A. ...
Tick-borne pathogens cause emerging zoonoses, and include fastidious organisms such as Anaplasma phagocytophilum. Because of their obligate intracellular nature, methods for mutagenesis and transformation have not been available. To facilitate genetic manipulation, we transformed A. phagocytophilum (Ap) to express a green fluorescent protein (GFP) with the Himar1 transposase system and selection with the clinically irrelevant antibiotic spectinomycin. These transformed bacteria (GFP/Ap) grow at normal rates and are brightly fluorescent in human, monkey, and tick cell culture. Molecular characterization of the GFP/Ap genomic DNA confirmed transposition and the flanking genomic insertion locations were sequenced. Three mice inoculated with GFP/Ap by intraperitoneal injection became infected as demonstrated by the appearance of morulae in a peripheral blood neutrophil and re-isolation of the bacteria in culture.
Nango is neutered (April-12-2015), up to date with routine shots, micro-chipped, de-wormed and tested negative for heartworm.. Was likely abandoned as a puppy, when found collar outgrew causing neck laceration: Debridement and suture performed 04-13-2015 with full recovery. Blood Test January-25-2018. X-Rays January-25-2018. Patellar Luxation Examination January-25-2018. Dental Cleaning January-25-2018. Idexx SNAP® 4Dx® (April-11-2015). Tested negative for Heartworm, Lyme, Ehrlichia Canis, and Anaplasma Phagocytophilum. Polymerase Chain Reaction PCR Test (May-14-2015). Tested negative for Babesia spp. (B. Canis and B. Gibsoni), Ehrlichia spp. (E. Canis and Anaplasma Platys), Haemobartonella Canis, and Borrelia Burgdorferi. ...
Azad, AF., Radulovic, S., Higgins, JA., Noden, BH., Troyer, JM., 1997. Flea-borne rickettsioses: ecologic considerations. Emerg. Infect. Dis. 3, 319-327.. Beck, W., Boch, K., Mackensen, H., Wiegand, B. and Pfister, K., 2006 Qualitative and quantitative observations of the flea population dynamics of dogs and cats in several areas in Germany. Veterinary Pararsitology, 137, 130-136.. Bermann, F., Davoust, B., Fournier, P.E., Brisou-Lapointe, A.V., Brouqui, P., 2002. Ehrlichia equi (Anaplasma phagocytophila) infection in an adult horse in France. Vet. Rec., 150, 787-788.. Beugnet, F., Kenny, MJ., Day, MJ. , Shaw, SE. A PCR-based comparative survey of arthropod-transmitted infections in dogs, cats and prevalence in ticks in southern France. Proceedings, WAAVP 2003, New Orleans.. Beugnet, F., Loukos, H., Chalvet-Monfray, K., Bicout, D., 2008. FleaTickRisk : a climatic model developed to monitor and predict the activity and the density of 3 ticks species and the cat flea in France. Proceedings EMOP X, ...
Edwards, AM, Dymock, D, Woodward, MJ and Jenkinson, HF (2002) Binding properties of Treponema denticola major surface protein (Msp). ...
Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions ...
Ha, S., Furukawa, R., Stramiello, M., Wagner, J.J., and Fechheimer, M. (2011). Transgenic Mouse Model for the Formation of Hirano Bodies. BMC Neurosci. 12:97. [Epub ahead of print]. Ha, S., Furukawa, R., and Fechheimer, M. (2011). Association of AICD and Fe65 with Hirano bodies reduces transcriptional activation and initiation of apoptosis. Neurobiol Aging. 32:2287-98.. Kim, D.-H., R. Furukawa, and M. Fechheimer. 2009. Degradation of Hirano Bodies by Autophagy 5, 44-51.. Davis, R. C., Furukawa, R., and M. Fechheimer, 2008. A Mammalian Cell Culture Model for the Formation of Hirano Bodies, Acta Neuropathologica 115, 205-217.. Stich, R. W., G. A. Olah, K. A. Brayton, W. C. Brown, M. Fechheimer, K. Green-Church, S. Jittapalapong, K. M. Kocan, T. C. McGuire, F. R. Rurangirwa, and G. H. Palmer. 2004. Identification of a novel Anaplasma marginale appendage-associated protein that localizes with actin filaments during intraerythrocytic infection. Infection and Immunity 72, 7257-7264.. Maselli, A., R. ...
In der vorliegenden in vitro Studie sollte der Frage nachgegangen werden, inwieweit die Teilkronenpräparation Einfluss auf die marginale Integrität der vollkeramischen Restauration im Schmelz und im Dentin nach thermomechanischer Wechselbelastung hat. Es wurden zwei unterschiedliche Präparationsformen gewählt, wobei der vestibuläre, nichttragende Höcker auf 1,0 mm Restzahnhartsubstanzstärke ausgedünnt (Präparation A) oder zusätzlich um ca. 2,0 mm horizontal reduziert und überkuppelt (Präparation B) wurde. Von den Zähnen wurden vor und nach thermomechanischer Wechselbelastung Epoxidharzreplikate hergestellt, an denen die marginale Integrität computergestützt bei 201 facher Vergrößerung mittels rasterelektronenmikroskopischer Randanalyse sowohl an allen Grenzen (Schmelz/Befestigungskomposit, Dentin/Befestigungskomposit und Keramik/Befestigungskomposit), als auch an allen Flächen (okklusal/vestibulär, palatinal, approximal/mesial und approximal/distal) ermittelt wurde. Bei ...
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I wanted to pass a little information to you all that cache with your pets, and also to make you aware of this as it can also affect humans. My dog was in serious joint pain and overall tenderness this week, lack of energy, and shivering at times. My first thought was lyme disease, as she has already experienced that quite a few years ago. Off to the vet we go, only to find out after blood work and testing in the office, that it is not lyme, but another tick issue called anaplasma. This is
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Hey everyone, Ive got a little problem with my platy. I have a m/f pair, the male is pretty good and gives her space, he doesnt harass her. The female has never given me fry, or at least Ive never seen any, so its possible thy are being eaten too quickly for me to ever notice them. But on to the problem. I noticed a bit of swelling at her anus/vent a few months ago, and assumed she was very pregnant. Every few weeks shed spend a night or two at the top of the tank, in the dead spot
Hey everyone, Ive got a little problem with my platy. I have a m/f pair, the male is pretty good and gives her space, he doesnt harass her. The female has never given me fry, or at least Ive never seen any, so its possible thy are being eaten too quickly for me to ever notice them. But on to the problem. I noticed a bit of swelling at her anus/vent a few months ago, and assumed she was very pregnant. Every few weeks shed spend a night or two at the top of the tank, in the dead spot
I had thought to linger around the house in my Jammies and not do much, except possibly go buy some female platys because the lone female does not appreciate their attentions ...
http://publications.ki.se/xmlui/discover?query=978-91-7409-752-8&submit=S%C3%B6k. 2011-10 Specialist in stomatognathic physioloogy (orofacial pain), Eastmaninstitutet Folktandvården AB. 2012-02 Doctoral Supervisor Training course, Karolinska Institutet. 2012-12 Teaching and learning in Higher Education, Karolinska Institutet. 2016-05 Specialist in Advanced Pain Medicine, Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI). 2017-01 Associate professor in odontology, Karolinska Institutet. ...
The genus Anaplasma consists of tick-transmitted obligate intracellular bacteria that invade white or red blood cells to cause debilitating and potentially fatal infections. A. phagocytophilum, a human and veterinary pathogen, infects neutrophils to cause granulocytic anaplasmosis. A. marginale invades bovine erythrocytes. Evidence suggests that both species may also infect endothelial cells in vivo. In mammalian and arthropod host cells, A. phagocytophilum and A. marginale reside in host cell derived pathogen-occupied vacuoles (POVs). While it was recently demonstrated that the A. phagocytophilum-occupied vacuole (ApV) intercepts membrane traffic from the trans-Golgi network, it is unclear if it or the A. marginale-occupied vacuole (AmV) interacts with other secretory organelles. Here, we demonstrate that the ApV and AmV extensively interact with the host endoplasmic reticulum (ER) in endothelial, myeloid, and/or tick cells. ER lumen markers, calreticulin and protein disulfide isomerase, and the ER
A TaqMan real-time PCR assay targeting the Anaplasma citrate synthase gene, gltA, was developed and used for detection of Anaplasma phagocytophilum in 765 Ixodes ricinus ticks collected from dogs and cats in northern Norway (n = 669) and Telemark county in southern Norway (n = 96). Among the ticks from northern Norway the prevalence of A. phagocytophilum was 3.0 %, while the prevalence in southern Norway was 2.1 % (p = 0.63). The gltA PCR assay showed a high analytical sensitivity (30 genomic units) and efficiency (98.5 %), and its utility in clinical diagnostics should be evaluated in future studies. This is the first report of A. phagocytophilum occurrence in ticks collected north of the Arctic Circle in Norway. The prevalence is comparable to that found in Telemark county in southern Norway.
To increase understanding of human bacterial and parasitic pathogens in bats, we investigated the prevalence of Babesia spp., Rickettsia spp., Anaplasma spp. and Coxiella burnetii in bats from China. Bats were captured from Mengyin County, Shandong Province of China using nets. DNA was extracted from the blood and spleen of bats for molecular detection of Babesia spp., Rickettsia spp., Anaplasma spp. and Coxiella burnetii with specific primers for each species. A total of 146 spleen samples and 107 blood samples of insectivorous bats, which belonged to 6 species within two families, were collected from Mengyin County, Shandong Province of China. We found that two Eptesicus serotinus (2/15, 13.3%) were positive for Babesia vesperuginis. We were unable to detect genomic sequences for Rickettsia spp., Anaplasma spp. and Coxiella burnetii. To our knowledge, our study showed for the first time the presence of Babesia vesperuginis in Eptesicus serotinus collected from China, suggesting that Babesia
Anaplasmosis in cattle is an infectious disease caused by a bacteria known as Anaplasma marginale. The disease is common in Missouri. Clinical cases can occur at any time of the year, but the majority of cases are seen in late summer and fall. The economic impact of the disease to the state is unknown, but nationwide it is estimated to exceed $300 million a year.1 Economic losses are due to reduced production, treatment costs, death loss and abortion.. Anaplasma marginale causes disease by infecting red blood cells. The immune systems recognizes the infected cells as abnormal and removes them, thereby creating anemia. The severity of disease is related to the number of infected red blood cells and subsequent red blood cell loss. In mild cases, animals may exhibit symptoms such as elevated temperature, depression and pale mucous membranes. In severe cases, animals may be jaundiced, the most obvious symptom of which is a yellow tinge to the mucous membranes around the eyes; exhibit severe ...
Fourteen vertebrate species (10 mammals and 4 birds) were assessed for their ability to transmit Anaplasma phagocytophilum, the bacterium that causes human granulocytic anaplasmosis, to uninfected feeding ixodid ticks. Small mammals were most likely to infect ticks but all species assessed were capable of transmitting the bacterium, in contrast to previous findings.
Human granulocytic anaplasmosis (HGA) is an emerging tick-borne disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils....
The aim of the study was to establish the role of forest birds as reservoirsof Anaplasma phagocytophilum and Babesia spp. in Wielkopolski National Park. A total of 108 birds from9 species were collected between May-September 2002. Blood samples were taken from 84 specimens and 442individuals of...
Anaplasma marginale is an important vector-borne rickettsia of ruminants in tropical and subtropical regions of the world. Immunization with purified outer membranes of this organism induces protection against acute anaplasmosis. Previous studies, with proteomic and genomic approach identified 21 proteins within the outer membrane immunogen in addition to previously characterized major surface protein1a-5 (MSP1a-5). Among the newly described proteins were VirB9, VirB10, and elongation factor-Tu (EF-Tu). VirB9, VirB10 are considered part of the type IV secretion system (TFSS), which mediates secretion or cell-to-cell transfer of macromolecules, proteins, or DNA-protein complexes in Gram-negative bacteria. EF-Tu can be located in the bacterial surface, mediating bacterial attachment to host cells, or in the bacterial cytoplasm for protein synthesis. However, the roles of VirB9, VirB10, and TFSS in A. marginale have not been defined. VirB9, VirB10, and EF-Tu have not been explored as vaccine ...
George Garrity, Don J. Brenner, James T. Staley, Noel R. Krieg, David R. Boone, Paul De Vos, Michael Goodfellow, Fred A. Rainey, Karl-Heinz Schleifer, ...,Bergeys Manual® of Systematic Bacteriology: Volume Two: The Proteobacteria, lk 123,2005,Googlei raamat veebiversioon (vaadatud 21.01.2014) (inglise keeles) ...
I just bought myself a Platy. Come to find out, it is pregnant! Her tummy is full and she should give birth anytime now. Platies do good with almost any fish. My Platy shares a tank with a Betta. The Betta, named Ditto, has already established a pecking order and makes sure that my Platy, Scyler, doesnt disobey his rules. If you have a pregnant fish of nearly any species, you should be sure there are plenty of hiding spots. Artificial or fake plants and stones will do. Hopefully my Platy babies escape in my tank stones and plants. I would be crushed if none survived. Im hoping the baby bunch will be born sometime during the day when I can check on Scyler to see if she has given birth. I have a better chance of finding the babies before its too late. Anyways, Platies make for good beginner fish and are quite easy to take care of ...
Cel mai adeasea, cei care locuiesc la bloc isi achizitioneaza si monteaza centrale termice cu condensare datorita faptului ca acestea consuma putina energie.. Nu trebuie sa mergi neaparat prin magazine si sa umbli zile in sir pentru a cumpara o centrala. Poti cumpara o centrala si online de pe Epinvest.ro. Intra pe site si consulta lista cu centralele disponibile.. Nu este convenabil sa cumperi centrale termice cu condensare atunci cand locuiesti la casa. Daca locuiesti la casa, cel mai convenabil este sa-ti achizitionezi o centrala termica pe lemne. Ai cu siguranta spatiu suficient pentru depozitarea lemnelor si suficient spatiu pentru camera in care tii centrala.. ...
anaplasmosis definition: an ailment of ruminants brought on by disease using the Anaplasma bacterium, usually sent by hard ticks.; a disease of cattle this is certainly sent by cattle ticks; comparable…
Obligatory intracellular, human ehrlichiosis agents Ehrlichia chaffeensis and Anaplasma phagocytophilum have remarkable abilities to parasitize first-line immune defensive cells, monocytes/macrophages and granulocytes, respectively. As newly discovered pathogens, the bacterial or host components, the signaling pathways required for their internalization and proliferation, and how these bacteria inhibit the microbicidal activities in host cells remain vastly unknown. In this study, we found that the entry of E. chaffeensis into THP-1 cells rapidly induces the following essential signaling events: protein cross-linking by transglutaminase, tyrosine phosphorylation, phospholipase C (PLC)-?2 activation, IP 3 production, and an increase in cytosolic free calcium levels. The entry and proliferation of these pathogens involve caveolae-mediated endocytosis and glycosylphosphatidylinositol-anchored proteins. Furthermore, caveolar marker protein caveolin-1, tyrosine-phosphorylated proteins, and PLC-?2 are ...
Infections by the ixodid tick-transmitted bacterial pathogen Anaplasma phagocytophilum are common in domestic ruminants and cervids in the coastal areas of southern Norway. Previous experimental work has shown that A. phagocytophilum strains recovered from red deer (Cervus elaphus) are infective in lambs, but epidemiological links between infections in red deer and sheep have yet to be established. To address this shortfall, the present study explores the genotypic relatedness between A. phagocytophilum strains infecting sympatric red deer and sheep. Blood from 32 lambs grazing on tick-infested pasture, and blood and tissues from 8 red deer shot in proximity to these pastures were collected during the summer and autumn of 2007. The presence of A. phagocytophilum in these samples was determined by PCR-based methods, and genotyping of detected strains was performed using comparative sequence analysis of 16S rDNA and msp4 fragments. A. phagocytophilum DNA was detected in 12 lambs and 7 red deer, 11 and 4
Anaplasma phagocytophilum and Borrelia burgdorferi are two tick-borne bacteria that cause disease in people and animals. For each of these bacteria, there is a complex of closely related genospecies and/or strains that are genetically distinct and have been shown through both observational and experimental studies to have different host tropisms. In this review we compare the known ecologies of these two bacterial complexes in the far western USA and find remarkable similarities, which will help us understand evolutionary histories and coadaptation among vertebrate host, tick vector, and bacteria. For both complexes, sensu stricto genospecies (those that infect humans) share a similar geographic range, are vectored mainly by ticks in the Ixodes ricinus-complex, utilize mainly white-footed mice (Peromyscus leucopus) as a reservoir in the eastern USA and tree squirrels in the far west, and tend to be generalists, infecting a wider variety of vertebrate host species. Other sensu lato genospecies within
Caramel is spayed (January-23-2018), up to date with routine shots, micro-chipped, de-wormed and tested negative for heartworm.. Blood Test December-29-2017, January-28-2018. Excessive drooling with warmer temperature, blood work on electrolytes and calcium revealed potassium in electrolytes lower resulting in slight liver inflammation, anti-inflammatory prescribed along with potassium supplements. X-Rays January-23-2018. Please note that x-rays only reflect when they were taken. Since shes still growing, hips and joints will be more fully developed when reaches the age of 1 for a more accurate assessment. Patellar Luxation Examination January-23-2018. Idexx SNAP® 4Dx® (November-29-2017). Tested negative for Heartworm, Lyme, Ehrlichia Canis, and Anaplasma Phagocytophilum. Polymerase Chain Reaction PCR Test (December-05-2017). Tested negative for Babesia spp. (B. Canis and B. Gibsoni), Ehrlichia spp. (E. Canis and Anaplasma Platys), Haemobartonella Canis, and Borrelia Burgdorferi. ...
Anaplasma, Anaplasma Marginale, Anaplasmataceae, Animal, Animals, Blood, Cattle, Deer, DNA, DNA Sequence, Ehrlichia, Ehrlichia Canis, Ehrlichia Ruminantium, Family, Genbank, Gene, Genotype, Infection, Parasites, PCR
Aim: Anaplasma marginale is a rickettsial pathogen responsible for progressive anemia in ruminants leading to huge economic losses. The objectives of this cross-sectional study were to determine the prevalence of anaplasmosis and therapeutic evaluation of traditional line of treatment.. Materials and Methods: A total of 168 cattle presented to Teaching Veterinary Clinical Complex, Lala Lajpat Rai University of Veterinary & Animal Sciences, Hisar during the period of 3 months (July-September, 2014) with history of fever, anorexia, reduced milk yield and tick infestation were analyzed for prevalence of hemoprotozoan diseases using classical giemsa stained thin blood smear parasitological method.. Results: Out of these 168 animals, 7 (4.17%) were found to be suffering from anaplasmosis on the basis of presence of dense, rounded, intra-erythrocytic bodies situated on or near the margin of the erythrocytes. Overall prevalence of theileriosis and babesiosis were found to be 42.9% and 1.8%, ...
Ticks are important vectors of disease and transmit an extensive array of bacterial, viral and protozoan diseases to both humans and dogs within a com
Ehrlichiosis in the United States is caused by three closely related bacterial species (Ehrlichia chaffeensis, Ehrlichia ewingii, and Anaplasma phagoc
Typically, cases of anaplasmosis increase in late summer and fall as insect vectors increase. Therefore, control of vectors is key to preventing anaplasmosis. If necessary herd treatment with oxytetracycline injection every 3 to 4 weeks during high risk times may be necessary will prevent clinical disease but animals can become carriers ...
Research at Centrale Nantes is carried out in highly competetif laboratories internationally recognized collaborations with industry. All fields of investigation are related to the science of engineering, i.e. automatic control, robotics, tele-communication, oceanic engineering, mechanics of materials and calculation of structures and civil engineering ...
BLOT-LINE kit for the detection of specific IgG antibodies to recombinant antigens of Borrelia species and Anaplasma phagocytophilum (HGA) in human serum, plasma and cerebrospinal fluid, for automated processing using the BlueDiver Instrument.
She was female, 2 monthsold and was anaemic and had no appetite for 3 days. Temperature was 39.9C. 2 siblings had passed away, 2 were OK and 1 had become lethargic. E canis Ab, Heartworm Ag, Lyme Ab and Anaplasma Ab were negative. Babesiosis was suspected ...
Alpharma Animal Health Shares Expert Panel Findings Bridgewater, N.J., May 25, 2010 - Alpharma Animal Health has launched an online webinar that discusses the current status of anaplasmosis in cattle in the U.S. The webinar is based on an expert ...
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Deformable Part Models with CNN Features Pierre-André Savalle 1, Stavros Tsogkas 1,2, George Papandreou 3, Iasonas Kokkinos 1,2 1 Ecole Centrale Paris, 2 INRIA, 3 TTI-Chicago Abstract. In this work we
The male Macropodus was frantic in the breeding box, and he was paying no attention to the nest, while the female was still trying to mate with him, so we decided to give them a second chance in the small tank. The nitrites were down to zero, so I netted out the platies and moved the Macropodus over. By thing morning there was a small nest full of eggs, and they seemed to be done, so I moved the female back to the community tank. The breeding box still has eggs as well, although there arent many bubbles left there. The eggs float, so I suppose well see what happens ...
Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma, which may be highly prognostic.
Candidatus Neoehrlichia mikurensis is a newly emerging tick-borne bacterium from the family Anaplasmataceae. Its presence in Ixodes ricinus ticks was reported from various European countries, however, its ecology and co-circulation with another member of the same family, Anaplasma phagocytophilum has not been rigorously studied yet. Candidatus N. mikurensis was detected in all sampling sites. In total, 4.5% of ticks were positive including larvae. The highest positivity was detected in Austria with a prevalence of 23.5%. The probability of Candidatus N. mikurensis occurrence increased with the proportion of ticks infected with Anaplasma phagocytophilum. A positive association between the occurrences of Candidatus N. mikurensis and A. phagocytophilum indicates that both bacteria share similar ecology for their natural foci in Central Europe.
En taxonomía, Anaplasmataceae es una familia de proteobacterias [1]​ intracelulares patógenas que infectan animales y que incluye los géneros Anaplasma, Ehrlichia, Neorickettsia y Wolbachia, los cuales tiene una relación entre sí según el siguiente cladograma.[2]​ Garrity, George (2005). Bergeys Manual of Systematic Bacteriology. Springer. ISBN 0-387-24145-0. Kelly P. Williams et al 2007, A Robust Species Tree for the Alphaproteobacteria J Bacteriol. 2007 July; 189(13): 4578-4586. Dumler (J.S.), Barbet (A.F.), Bekker (C.P.J.), Dasch (G.A.), Palmer (G.H.), Ray (S.C.), Rikihisa (Y.) and Rurangirwa (F.R.): Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, description of six new species combinations and designation of Ehrlichia equi and HGE agent as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. ...
Effects of adding phenol to sera used for the card-agglutination test (CAT) and for the micro-complement-fixation test (CFT) for bovine anaplasmosis were studied. Sera were obtained from 14 recently infected cattle, 17 cattle vaccinated with a killed anaplasmosis vaccine, 5 cattle in the carrier phase of the disease, and 45 cattle of unknown anaplasmosis status. Aliquots of sera were tested with and without phenol (0.25% final concentration). Phenol adversely affected the CAT by causing false-negative results. The CAT reactions of nonphenolized sera from recently infected cattle were all positive 4 weeks after inoculation, whereas CAT reactions of phenolized sera were not all positive until 10 weeks after inoculation. Nine non-phenolized sera from vaccinated cattle that were CAT-positive were CAT-negative after being phenolized. Phenolized sera from carrier cattle and from cattle of unknown anaplasmosis status were less reactive on the CAT than were nonphenolized sera. Effects of phenol on the CFT were
Ehrlichia phagocytophila (Genus Ehrlichia, Order Rickettsiales) is the pathogen responsible for Tick-borne fever, a disease of high morbidity in susceptible ruminants. These bacteria appear to be almost identical at serological and molecular level to granulocytic Ehrlichia species recently diagnosed in humans, dogs and horses of Europe and the United States. A molecular description of different isolates of the pathogen is given. Samples were derived from wild and domestic vertebrate hosts from Europe, including the UK where Tick-borne fever is endemic. Molecular characterisation of a fragment from the groE operon gene showed higher nucleotide variation than at 16S rDNA level. Human and equine isolates from Europe differed from North American samples, which in 16S sequence appeared to be identical. Thus, emerging cases of granulocytic ehrlichiosis in Europe are likely to be associated with strain variants of E. phagocytophila. Further differences were also found between ruminant and non-ruminant ...
Anaplasmataceae é uma família do filo Proteobacteria. Anaplasma Theiler 1910 Aegyptianella Carpano 1929 Ehrlichia Moshkovski 1945 Neoehrlichia Neorickettsia Philip et al. 1953 Wolbachia Hertig 1936 Xenohaliotis Garrity, George (2005). Bergeys Manual of Systematic Bacteriology. [S.l.]: Springer. ISBN 0-387-24145-0 ...
Si espone uno schema semplificato della classificazione dei tumori del sistema nervoso centrale (SNC), secondo lOrganizzazione mondiale della sanità. In parentesi tonda viene riportata la denominazione ufficiale del WHO-2007, insieme al codice ICD-O (International Classification of Diseases for Oncology, Classificazione Internazionale delle Malattie per lOncologia). Si ha: /0 per i tumori benigni, /3 per i tumori maligni e /1 per i tumori borderline. Viene poi aggiunto in parentesi (quando disponibile o applicabile) il WHO Grading (vedi Gradazione dei tumori del sistema nervoso centrale), con la sigla "WHO grade" seguita da numerazione romana. Di questo parametro, legato concettualmente all"aggressività" della neoplasia, si dirà più estesamente nella descrizione del singolo tumore. Della definizione italiana si riporta la versione comunemente usata in letteratura. Quando rinvenute più di una, una seconda è in parentesi quadra. 1.1. Tumori astrocitari (Astrocytic Tumours) 1.1.1 ...
The os centrale carpi is an accessory ossicle of the wrist positioned dorsally between the scaphoid, the trapezoid and the capitate bones 1. As with most other accessory ossicles of the wrist, the os centrale carpi is a rare finding on imaging an...
A composite including a polymeric film having a first generally planar major surface and an opposite second major surface defined by a multiplicity of elongate parallel contiguous ridge portions. The ridge portions each have a generally triangular cross section and elongate obscured and transmitting second major surface portions intersecting at the apex of the ridge with the obscured second major surface portion being on the side of the ridge generally facing a first end of the sheet and the transmitting second major surface portions being on the side of the ridge portions adjacent a second end of the sheet. The film can provide visual transmission between its first major surface and the transmitting second major surface portions while coatings along the obscured second major surface portions prevent viewing of visual images through the film; whereas the composite can also provide light transmission between the first major surface and the transmitting second major surface portions, while the coatings
Ehrlichiosis definition, an infection caused by bacteria of the genus Ehrlichia, which are thought to be transmitted to humans and animals by ticks. See more.
An insulating unit includes a first and a second sheet, each of the sheets having a first major surface and an opposite second major surface; an arrangement to position the first and second sheets in spaced relation to one another to provide a compartment between the sheets, the second major surface of the first sheet and the first major surface of the second sheet facing the compartment; a lattice made of muntin bars in the compartment, the lattice having end portions adjacent to and spaced from the arrangement; and a retainer clip having a first end portion connected to an end portion of the lattice and the opposite second end portion having a compressible base, the compressible base in surface contact with the second major surface of the first sheet and the first major surface of the second sheet to retain the lattice in position between the sheets.
Massart A, Pallier A, Pascual J, Viklicky O, Budde K, Spasovski G, Klinger M, Sever MS, Sørensen SS, Hadaya K, Oberbauer R, Dudley C, De Fijter JW, Yussim A, Hazzan M, Wekerle T, Berglund D, De Biase C, Pérez-Sáez MJ, Mühlfeld A, Orlando G, Clemente K, Lai Q, Pisani F, Kandus A, Baas M, Bemelman F, Ponikvar JB, Mazouz H, Stratta P, Subra JF, Villemain F, Hoitsma A, Braun L, Cantarell MC, Colak H, Courtney A, Frasca GM, Howse M, Naesens M, Reischig T, Serón D, Seyahi N, Tugmen C, Alonso Hernandez A, Beňa L, Biancone L, Cuna V, Díaz-Corte C, Dufay A, Gaasbeek A, Garnier A, Gatault P, Gentil Govantes MA, Glowacki F, Gross O, Hurault de Ligny B, Huynh-Do U, Janbon B, Jiménez Del Cerro LA, Keller F, La Manna G, Lauzurica R, Le Monies De Sagazan H, Thaiss F, Legendre C, Martin S, Moal MC, Noël C, Pillebout E, Piredda GB, Puga AR, Sulowicz W, Tuglular S, Prokopova M, Chesneau M, Le Moine A, Guérif P, Soulillou JP, Abramowicz M, Giral M, Racapé J, Maggiore U, Brouard S, Abramowicz D. The ...
Histoire de lIran contemporain, conflits du Moyen-Orient, géopolitique de lAsie centrale, de lespace caspien et du Caucase. Enseignements donnés ces dernières années: Moyen-Orient, Caucase et Asie centrale : enjeux politiques régionaux et ...
Ce document de stratégie genre en matière de REDD+ et adaptation au changement climatique est le fruit du travail de léquipe du Réseau Femmes Afri...
Histoire de lIran contemporain, conflits du Moyen-Orient, géopolitique de lAsie centrale, de lespace caspien et du Caucase. Enseignements donnés ces dernières années: Moyen-Orient, Caucase et Asie centrale : enjeux politiques régionaux et ...
The hotel is a 10-minute walk from the historic center of Mulhouse and the SNCF train station and offers a 24-hour reception. All rooms are non-smoking and are equipped with reverse-cycle air conditioning. The shower rooms are equipped with a hair dryer.
Κάποιοι επιχειρηματιες δεν περιμένουν το μάνα εξ ουρανού αλλα καινοτομούν. Μπράβο στο Central
The main objective of my PhD has been focused to the analysis and characterization of milk and dairy products derived from "Centrale del Latte di Salerno" in order to assess their potential use as dietary supplements and ...
Note: - Feullies lachement pinnatipartites; calathides de silhouette ovale oblongue; bractées du péricline à partie centrale allant du pale au brun foncé; akènes pubescents, 2 1/2 cent., couronnés dune aigrette blanche étalée, 1 1/2 cent., soies très inégales. Dupl. Ph G. Wagenitz (GOET) 1987-09-25: (von C. deusta weit entfernt) Isotypus der...
In recent years, some tick-borne diseases such as anaplasmosis and ehrlichiosis became widespread worldwide, threatening the health of humans, domestic animals and wildlife. The aims of this study were to determine the presence of Anaplasma phagocytophilum, Ehrlichia canis, and Ehrlichia chaffeensis in 102 opossums (Didelphis spp.) and 44 owned free-ranging dogs in southeastern Mexico using a specific polymerase chain reaction (PCR). A. phagocytophilum was detected in opossums and dogs with a prevalence of 3 and 27%, respectively. E. canis was only present in 7% of dogs, while we didnt detect E. chaffeensis in any host. We report the first evidence of infections of A. phagocytophilum in Didelphis virginiana and D. marsupialis in Mexico. The infection rates and patterns we found of A. phagocytophilum suggest that dogs are more directly involved in the ecology of this pathogen than opossums. Despite the small prevalence found, our results are of public health concern because of the zoonotic capabilities
We recently reported a novel Ehrlichia sp. closely related to E. muris detected in blood of 4 from patients in Minnesota (MN) and Wisconsin (WI) in 2009 (NEJM 2011). We now present data from the 2009-2011 patient cases, and results of tick, rodent, and deer studies. Blood from patients with suspected ehrlichiosis or anaplasmosis was tested using PCR targeting the Ehrlichia/Anaplasma Heat Shock Operon gene. PCR was also performed on rodent and deer blood, ticks from MN and WI, and ticks found on military personnel at 132 U.S. military bases nationwide (2007-2010). Select specimens were characterized using culture and DNA sequencing. Human sera were tested for antibodies to specific Ehrlichia spp. and A. phagocytophilum. During 6/2009-8/2011, blood from 32 of 8,110 MN and WI patients tested PCR positive for an Ehrlichia sp. other than E. chaffeensis and E. ewingii. This result was also detected from 1 North Dakota patient who recently travelled to MN. The result was not noted among 7,827 other patient
This workshop proceeding discusses the importance of anaplasmosis, babesiosis and cowdriosis; the methods of control being used for the diseases and the problems encountered with these control methods; recent findings in the epidemiology and molecular biology of these diseases, and developments towards new vaccines. Topics of discussion include distribution, economic importance, control measures, diagnosis, approaches to new vaccines, and in vitro cultivation. Under the topic diagnosis, papers are presented on development of diagnostic reagents for anaplasmosis and babesiosis; serodiagnosis of Cowdria ruminantium, and DNA probes for this species. The papers under approaches to new vaccines examine molecular biology of rickettsiae with particular reference to gene organization and structure in Anaplasma marginale and Cowdria ruminantium; methodological approaches to the study of resistance in cowdriosis and the possible role of cell-mediated immunity; progress in development of subunit vaccines ...
Antibiotic and feed additive for livestock. For control of bacterial pneumonia associated with shipping fever complex caused by Pasteurella spp.; Control of active infection of anaplasmosis caused by Anaplasma marginale susceptible to chlortetracycline; Treatment of bacterial enteritis caused by Escherichia coli and bacterial pneumonia caused by Pasteurella multocida ...
Anaplasmosis: on an epidemiological point of view, it was not immediately clear if our patient had been exposed to tick infested in rural areas or had been in contact with pets or wild animals. Nevertheless, his stay in town parks and night cohabitation with homeless people could well have exposed him to ticks. The absence of acute phase reactants in a highly febrile patient was another intriguing point. Actually, Anaplasma phagocytophylum has as virulence factor the escape from neutrophil phagocytosis, through the inhibition of phagolysosome fusion. Although it is a potent inducer of -- INF, at the same time it behaves as an inhibitor suppressing the expression of -- INF membrane receptors and inhibiting the proinflammatory action in favour of bacterial multiplication withi n neutrophils (5- 6). The apparent failure of the appropriate treatment for anaplasmosis was another point of doubt since, despite the abatement of fever, the clinical course tended toward a greater severity. Limited ...
Anaplasma phagocytophilum and Ehrlichia chaffeensis cause emerging potentially fatal infectious diseases human granulocytic anaplasmosis (HGA) and human monocyt...
Anaplasmosis is a tick-borne transmitted infection. Its clinical expression include fever, cytopenia and hepatitis.This infection was initially described in United States. In Europe, its epidemiology is not well known. Some isolated cases have been diagnosed in several country, were the tick Ixodes ricinus is known to transmitted another infection :the Lyme borreliosis.The purpose of our study is to look systematically for Anaplasmosis, in patient living in Eastern France, and presenting with compatible clinical symptoms using a new diagnosis tool : PCR in blood samples. So we will have new data about epidemiology in our country and the clinical symptoms that are associated with Anaplasmosis ...
Heartwater is a notifiable disease that is listed by the World Organisation for Animal Health. It is caused by Ehrlichia ruminantium, an obligately intracellular Gramnegative bacterium in the order Rickettsiales and the family Anaplasmataceae. The disease is borne by ticks in the genus Amblyomma and causes heartwater, or cowdriosis, in wild and domestic ruminants, primarily in Africa, but also in parts of the Caribbean. The disease was recognised in South Africa in the 19th Century and determined to be tick borne in 1900, while the organism was identified in 1925 and first cultured in vitro in 1985. This latter achievement boosted research into the disease at a time when biology was moving into the molecular genetic age. Over the last 20 years, there have been significant improvements in our understanding of E. ruminantium, yielding major advances in diagnosis, epidemiology, genetic characterisation, phylogeny, immunology, and vaccine development ...
Anaplasmosis is transmitted by the black-legged tick, which is the same tick that spreads Lyme disease, and the most common tick found in Vermont. As of September, 133 cases of anaplasmosis have been reported, only six fewer than were reported for all of 2015.. Although anaplasmosis cases peak in the spring and summer, a second surge in illnesses occurs in the autumn. That is when adult ticks are hungry and looking for another blood meal before winter arrives.. "Anaplasmosis is a serious illness, and were seeing more of it in Vermont," said Bradley Tompkins, infectious disease epidemiologist. According to Tompkins, over one-third of the anaplasmosis cases reported to the Health Department are sick enough to be hospitalized, compared to 3 percent for Lyme disease. Symptoms can include fever, headache, chills and muscle aches. Anaplasmosis can be successfully treated with antibiotics, especially if treatment is given early.. Tompkins urges people to not drop their guard just because summer is ...
INTRODUCTION Anaplasmosis in cattle is an arthropod-borne disease caused predominantly by the intraerythrocytic rickettsia Ana-plasma marginale21. Anaplasmosis is characterised by mucosal pallor, depression, inappetance, general weakness and a rapidly rising parasitaemia21. Pyrexia is an inconsistent finding21. The severity of clinical disease is directly related to the age of the animal: in animals less than 1 year old it is usually subclinical, in yearlings and 2-year-olds it is moderately severe while in older cattle it is severe and often fatal9. Vertical transmission of anaplasmosis has been documented, although its significance in the spread of the diseases is unclear13,27,28,31. Experiments attempting to demonstrate vertical transmission where progeny from known Anaplasma carrier cows were utilised, as well as where cows were acutely infected with Anaplasma during gestation, did not produce clinically ill progeny13,27,31. In utero transmission has either been demonstrated by inoculating ...
OVERVIEW: Anaplasma species, Ehrlichia species and Rickettsia species are vector-borne pathogens infecting a wide variety of mammals, but causing disease in very few of them. Infection in cats: Anaplasma phagocytophilum is the most important feline pathogen among these rickettsial organisms, and coinfections are possible. Little information is available on the pathogenesis of these agents in cats. Clinical signs are usually reported soon after tick infestation. They are mostly non-specific, consisting of fever, anorexia and lethargy. Joint pain may occur. Infection in humans: Some rickettsial species ( A phagocytophilum, Ehrlichia chaffeensis, Ehrlichia ewingii, Rickettsia conorii, Rickettsia rickettsii, Rickettsia felis, Rickettsia typhi and Candidatus Neoehrlichia mikurensis) are of zoonotic concern. Direct contact with cat saliva should be avoided because of potential contamination by R felis. Infected cats are sentinels of the presence of rickettsial pathogens in ticks and fleas in a given ...

Anaplasmosis | Anaplasmosis | CDCAnaplasmosis | Anaplasmosis | CDC

Anaplasmosis is a tickborne disease caused by the bacterium Anaplasma phagocytophilum. It was previously known as human ... Anaplasmosis is a disease caused by the bacterium Anaplasma phagocytophilum. These bacteria are spread to people by tick bites ...
more infohttps://www.cdc.gov/anaplasmosis/

Anaplasma - WikipediaAnaplasma - Wikipedia

Anaplasma marginale and Anaplasma centrale in cattle Anaplasma mesaeterum and Anaplasma ovis in sheep and goats Anaplasma ... Anaplasma phagocytophilum Anaplasma platys Anaplasmosis Parte, A.C. "Anaplasma". www.bacterio.net. Anaplasmas reviewed and ... Anaplasma genomes in the JGI genome browser Anaplasma at the US National Library of Medicine Medical Subject Headings (MeSH) ... Anaplasma Genome Projects (from Genomes OnLine Database) Comparative Analysis of Anaplasma Genomes (at DOEs IMG system). ...
more infohttps://en.wikipedia.org/wiki/Anaplasma

Anaplasma phagocytophilum - WikipediaAnaplasma phagocytophilum - Wikipedia

Anaplasma phagocytophilum HZ Genome Page Anaplasma phagocytophilum at the US National Library of Medicine Medical Subject ... Anaplasma phagocytophilum is a small, obligate, intracellular bacterium with a Gram-negative cell wall. It is 0.2-1.0 μm and ... Page Anaplasma on bacterio.net Dumler JS, Barbet AF, Bekker CP, et al. (2001). "Reorganization of genera in the families ... Anaplasma phagocytophilum (formerly Ehrlichia phagocytophilum) is a gram-negative bacterium that is unusual in its tropism to ...
more infohttps://en.wikipedia.org/wiki/Anaplasma_phagocytophilum

Anaplasma Co-infections | Anaplasmosis | CDCAnaplasma Co-infections | Anaplasmosis | CDC

Anaplasmosis is a tickborne disease caused by the bacterium Anaplasma phagocytophilum. It was previously known as human ... Anaplasma coinfection with non-rickettsial pathogens has been reported in ,10% of patients. ...
more infohttps://www.cdc.gov/anaplasmosis/healthcare-providers/co-infections.html

Anaplasma Phagocytophilum Infection | Summary | NNDSSAnaplasma Phagocytophilum Infection | Summary | NNDSS

Anaplasma phagocytophilum infection 2008. Current. Ehrlichia chaffeensis infection(https://wwwn.cdc.gov/nndss/conditions/ ... Ehrlichiosis and Anaplasmosis , 2008 Case Definition (https://wwwn.cdc.gov/nndss/conditions/anaplasma-phagocytophilum-infection ...
more infohttps://wwwn.cdc.gov/nndss/conditions/anaplasma-phagocytophilum-infection/

Anaplasma marginale - microbewikiAnaplasma marginale - microbewiki

Anaplasma marginale str. Florida; Anaplasma marginale str. Illinois; Anaplasma marginale str. St. Maries; Anaplasma marginale ... Anaplasma marginale (Theiler, 1910) Description and significance. Anaplasma marginale is the most prevalent tick-borne, ... 5) NCBI Taxonomy Browser, "Anaplasma marginale" Retrieved 30 April, 2007 6) TGR-CMR, "Anaplasma marginale St. Maries Genome" ... "D425 Anaplasma Marginale" 8) Ueti MW, Reagan JO Jr, Knowles DP Jr, Scoles GA, Shkap V, Palmer GH., "Identification of midgut ...
more infohttps://microbewiki.kenyon.edu/index.php/Anaplasma_marginale

Anaplasma phagocytophilum - Vikipeedia, vaba entsüklopeediaAnaplasma phagocytophilum - Vikipeedia, vaba entsüklopeedia

Nieto NC, Foley JE, Bettaso J, Lane RS.,Reptile infection with Anaplasma phagocytophilum, the causative agent of granulocytic ... Selles artiklis on kasutatud saksakeelset artiklit de:Anaplasma phagocytophilum seisuga 22.01.2014. ... Varem on seda bakterit nimetatud mitmeti: Anaplasma phagocytophila, Ehrlichia phagocytophilum ja Ehrlichia phagocytophila, ka ... Anaplasma phagocytophilum muudab rakkudevahelist suhtlust selliselt, et suureneks IL-1 ja IL-8 tsütokiinide osakaal, ning see ...
more infohttps://et.wikipedia.org/wiki/Anaplasma_phagocytophilum

Identification of Anaplasma marginale Type IV Secretion System Effector ProteinsIdentification of Anaplasma marginale Type IV Secretion System Effector Proteins

Background Anaplasma marginale, an obligate intracellular alphaproteobacterium in the order Rickettsiales, is a tick-borne ...
more infohttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027724

Anaplasma phagocytophilum in central and western Wisconsin: a molecular survey.  - PubMed - NCBIAnaplasma phagocytophilum in central and western Wisconsin: a molecular survey. - PubMed - NCBI

Anaplasma phagocytophilum in central and western Wisconsin: a molecular survey.. Michalski M1, Rosenfield C, Erickson M, Selle ... Anaplasma phagocytophilum is an obligate intracellular bacterium that is transmitted to humans through the bite of Ixodes spp. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16738890?dopt=Abstract

dermacentor variabilis[Text Word] AND anaplasma marginale[Text Wor - PubMed - NCBI"dermacentor variabilis"[Text Word] AND "anaplasma marginale"[Text Wor - PubMed - NCBI

Silencing expression of the defensin, varisin, in male Dermacentor variabilis by RNA interference results in reduced Anaplasma ... Experimental transmission of bovine anaplasmosis (caused by Anaplasma marginale) by means of Dermacentor variabilis and D. ... Silencing of genes involved in Anaplasma marginale-tick interactions affects the pathogen developmental cycle in Dermacentor ... Capillary tube feeding system for studying tick-pathogen interactions of Dermacentor variabilis (Acari: Ixodidae) and Anaplasma ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?term=%22dermacentor+variabilis%22%5BText+Word%5D+AND+%22anaplasma+marginale%22%5BText+Word%5D

bioB - Biotin synthase - Anaplasma phagocytophilum (strain HZ) - bioB gene & proteinbioB - Biotin synthase - Anaplasma phagocytophilum (strain HZ) - bioB gene & protein

Anaplasma phagocytophilum str. JM. Anaplasma phagocytophilum str. MRK. Anaplasma phagocytophilum str. NCH-1. Anaplasma ... Anaplasma phagocytophilum str. JM. Anaplasma phagocytophilum str. MRK. Anaplasma phagocytophilum str. NCH-1. Anaplasma ... Anaplasma phagocytophilum str. JM. Anaplasma phagocytophilum str. MRK. Anaplasma phagocytophilum str. NCH-1. Anaplasma ... Anaplasma phagocytophilum str. CRT53-1. Anaplasma phagocytophilum str. CRT38. Anaplasma phagocytophilum str. ApMUC09. 322. ...
more infohttp://www.uniprot.org/uniprot/Q2GLB4

Anaplasma phagocytophilum and Borrelia burgdorferi in rabbits from southeastern China.Anaplasma phagocytophilum and Borrelia burgdorferi in rabbits from southeastern China.

A total of 54 wild rabbits captured from southeastern China were examined for Anaplasma phagocytophilum and Borrelia ... Anaplasma phagocytophilum and Borrelia burgdorferi in rabbits from southeastern China.. *. [ Not Yet Rated ] [ Discuss This ... A total of 54 wild rabbits captured from southeastern China were examined for Anaplasma phagocytophilum and Borrelia ...
more infohttp://www.prohealth.com/library/showarticle.cfm?libid=22628

KEGG PATHWAY: Ubiquinone and other terpenoid-quinone biosynthesis - Anaplasma marginale FloridaKEGG PATHWAY: Ubiquinone and other terpenoid-quinone biosynthesis - Anaplasma marginale Florida

Ubiquinone and other terpenoid-quinone biosynthesis - Anaplasma marginale Florida [ Pathway menu , Organism menu , Pathway ...
more infohttp://www.genome.jp/kegg-bin/show_pathway?amf00130

Anaplasma phagocytophilum infection in a multi-species deer community in the New Forest, England | SpringerLinkAnaplasma phagocytophilum infection in a multi-species deer community in the New Forest, England | SpringerLink

The tick-transmitted Anaplasma phagocytophilumhas been recorded in a range of mammal species and causes granulocytic ... Kenny MJ, Parsons I, Shaw SE, Beugnet F (2003) Anaplasma (Ehrlichia) phagocytophilum infection in a UK fallow deer (Dama dama) ... Stuen S (2007) Anaplasma phagocytophilum-the most widespread tick-borne infection in animals in Europe. Vet Res Commun 31(Suppl ... Adamska M (2006) Detecting Anaplasma phagocytophilum DNA in blood of roe deer and in ticks. Med Weter 62:201-203 In Polish with ...
more infohttps://link.springer.com/article/10.1007%2Fs10344-009-0261-8

Molecular detection of Ehrlichia canisand Anaplasma platys in dogs in Southern BrazilMolecular detection of Ehrlichia canisand Anaplasma platys in dogs in Southern Brazil

Table 1. Anemia and thrombocytopenia associated with positive PCR forAnaplasma platys or serology forAnaplasma spp. from dogs. ... Cross-reaction evaluation of PCR-Anaplasma platys positive dogs tested to Anaplasma phagocytophilum antibodies by commercial ... Table 2. Anaplasma spp. serology and Anaplasma platys nPCR results in dogs. ... Positive Anaplasma sp. nPCR results with negative serological results might also indicate an early stage of infection.Anaplasma ...
more infohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612013000300360&lng=en&tlng=en

Anaplasma phagocytophilum | Article about Anaplasma phagocytophilum by The Free DictionaryAnaplasma phagocytophilum | Article about Anaplasma phagocytophilum by The Free Dictionary

A genus of the family Anaplasmataceae; organisms form inclusions in red blood cells of ruminants Explanation of Anaplasma ... Looking for Anaplasma phagocytophilum? Find out information about Anaplasma phagocytophilum. ... Anaplasma. (redirected from Anaplasma phagocytophilum). Also found in: Medical, Wikipedia. Anaplasma. [‚an·ə′plaz·mə] ( ... equi and is now referred to as Anaplasma phagocytophilum (which will be used throughout the rest of the discussion).. Human ...
more infohttps://encyclopedia2.thefreedictionary.com/Anaplasma+phagocytophilum

Anaplasma marginale | Article about Anaplasma marginale by The Free DictionaryAnaplasma marginale | Article about Anaplasma marginale by The Free Dictionary

A genus of the family Anaplasmataceae; organisms form inclusions in red blood cells of ruminants Explanation of Anaplasma ... Looking for Anaplasma marginale? Find out information about Anaplasma marginale. ... Anaplasma. (redirected from Anaplasma marginale). Also found in: Medical. Anaplasma. [‚an·ə′plaz·mə] (microbiology) A genus of ... and Anaplasma marginale (among bacteria) and African trypanosomes, Plasmodium falciparum, and Babesia bovis (among parasites) ...
more infohttp://encyclopedia2.thefreedictionary.com/Anaplasma+marginale

Pathogens | Free Full-Text | Comparative Genomics Identifies a Potential Marker of Human-Virulent Anaplasma phagocytophilumPathogens | Free Full-Text | Comparative Genomics Identifies a Potential Marker of Human-Virulent Anaplasma phagocytophilum

We have previously described a comparative genome analysis of nine strains of Anaplasma phagocytophilum that showed similarity ... Keywords: human anaplasmosis; Anaplasma phagocytophilum; comparative genomics; diagnosis; PCR human anaplasmosis; Anaplasma ... Comparative Genomics Identifies a Potential Marker of Human-Virulent Anaplasma phagocytophilum. Basima Al-Khedery 1. ... Al-Khedery, B.; Barbet, A.F. Comparative Genomics Identifies a Potential Marker of Human-Virulent Anaplasma phagocytophilum. ...
more infohttp://www.mdpi.com/2076-0817/3/1/25

Sequence Analysis of the msp4 Gene of Anaplasma phagocytophilum Strains | Journal of Clinical MicrobiologySequence Analysis of the msp4 Gene of Anaplasma phagocytophilum Strains | Journal of Clinical Microbiology

Sequence Analysis of the msp4 Gene of Anaplasma phagocytophilum Strains. José de la Fuente, Robert F. Massung, Susan J. Wong, ... Sequence Analysis of the msp4 Gene of Anaplasma phagocytophilum Strains. José de la Fuente, Robert F. Massung, Susan J. Wong, ... msp4 sequences for Anaplasma centrale (GenBank accession number AF428090), Anaplasma ovis (AF393742), and A. marginale (GenBank ... and Anaplasma spp. was done using the msp4 data for A. phagocytophilum, A. marginale, A. centrale, and A. ovis; the E. ...
more infohttps://jcm.asm.org/content/43/3/1309?ijkey=06b3fc36293bf8486d027cd4d226652ea58ee97a&keytype2=tf_ipsecsha

Ehrlichia and AnaplasmaEhrlichia and Anaplasma

Anaplasma phagocytophilum is transmitted by Ixodes scapularis, the vector of Lyme disease, on the East Coast of the U.S. and ... In the endemic states, from 10-50% of the captured Ixodes ticks carry Anaplasma spp. In addition, since Amblyomma americanum ... Qualitative Activity of Antimicrobials Against Ehrlichia and Anaplasma.. Antimicrobial. Inhibitory. Bactericidal. Doxycycline( ... Anaplasma phagocytophilum is transmitted by Ixodes scapularis, the same tick responsible for Lyme disease. Consequently, the ...
more infohttps://www.endocrinologyadvisor.com/infectious-diseases/ehrlichia-and-anaplasma/article/609775/

Clinical Isolation of Anaplasma phagocytophilum in South Korea | The American Journal of Tropical Medicine and HygieneClinical Isolation of Anaplasma phagocytophilum in South Korea | The American Journal of Tropical Medicine and Hygiene

We report the first isolation of Anaplasma phagocytophilum in South Korea. A 61-year-old woman presented with a 6-day history ... New genetic variants of Anaplasma phagocytophilum and Anaplasma bovis from Korean Water Deer (Hydropotes inermis argyropus). ... oa Clinical Isolation of Anaplasma phagocytophilum in South Korea * Seung Hun Lee1,†, Se Yoon Park2,5,†, Mi Jin Jang1, Ki Ju ... Anaplasma phagocytophilum, interferon gamma production and Stat1 signaling. Microbiol Immunol 57: 207-212.. [Google Scholar] ...
more infohttp://www.ajtmh.org/content/journals/10.4269/ajtmh.16-0529

Genetic Variability and Stability of Anaplasma phagocytophila msp2 (p44) | Infection and ImmunityGenetic Variability and Stability of Anaplasma phagocytophila msp2 (p44) | Infection and Immunity

Genetic Variability and Stability of Anaplasma phagocytophila msp2 (p44). Karen Caspersen, Jin-Ho Park, Surekha Patil, J. ... Genetic Variability and Stability of Anaplasma phagocytophila msp2 (p44). Karen Caspersen, Jin-Ho Park, Surekha Patil, J. ... Genetic Variability and Stability of Anaplasma phagocytophila msp2 (p44). Karen Caspersen, Jin-Ho Park, Surekha Patil, J. ... The immunoprotective Anaplasma marginale major surface protein 2 is encoded by a polymorphic multigene family. Infect. Immun. ...
more infohttps://iai.asm.org/content/70/3/1230?ijkey=a905ffb5e3e2cfea83e5eaa9eee1d6b25de0d3c5&keytype2=tf_ipsecsha
  • Anaplasma the variation of P44 protein species in further confirmed the specific reaction phagocytophilum HL60 cells ( 2 , 5 ). (cdc.gov)
  • The tick-transmitted Anaplasma phagocytophilum has been recorded in a range of mammal species and causes granulocytic ehrlichiosis in humans, horses, and companion animals as well as tick-borne fever in ruminants. (springer.com)
  • Transmission electron microscopy identified multiple ER-POV membrane contact sites on the cytosolic faces of both species' vacuoles that corresponded to areas on the vacuoles' lumenal faces where intravacuolar Anaplasma organisms closely associated. (frontiersin.org)
  • These data establish the ApV and AmV as pathogen-host interfaces that directly engage the ER in vertebrate and invertebrate host cells and evidence the conservation of ER parasitism between two Anaplasma species. (frontiersin.org)
  • The genus Anaplasma which contains both animal and human pathogens. (kenyon.edu)
  • Casey ANJ, Birtles RJ, Radford AD, Bown KJ, French NP, Woldehiwet Z, Ogden NH (2004) Groupings of highly similar major surface protein (p44)-encoding paralogues: a potential index of genetic diversity amongst isolates of Anaplasma phagocytophilum . (springer.com)
  • Propagation of the Israeli vaccine strain of Anaplasma centrale in tick cell lines. (nih.gov)
  • Serum samples from 196 dogs were first tested using dot-ELISA for antibodies against Anaplasma spp. (scielo.br)