Loss of structural differentiation and useful function of neoplastic cells.
A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
A form of RHABDOMYOSARCOMA arising primarily in the head and neck, especially the orbit, of children below the age of 10. The cells are smaller than those of other rhabdomyosarcomas and are of two basic cell types: spindle cells and round cells. This cancer is highly sensitive to chemotherapy and has a high cure rate with multi-modality therapy. (From Holland et al., Cancer Medicine, 3d ed, p2188)
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
Tumors or cancers of the KIDNEY.
A nutritional reservoir of fatty tissue found mainly in insects and amphibians.
A plant family of the order Pinales, class Pinopsida, division Coniferophyta (conifers). They are mainly resinous, aromatic evergreen trees.
A species of ALPHAVIRUS associated with epidemic EXANTHEMA and polyarthritis in Australia.
A worm-like blind tube extension from the CECUM.
A specialized barrier in the kidney, consisting of the fenestrated CAPILLARY ENDOTHELIUM; GLOMERULAR BASEMENT MEMBRANE; and glomerular epithelium (PODOCYTES). The barrier prevents the filtration of PLASMA PROTEINS.
A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
ENDOCARDIUM infection that is usually caused by STREPTOCOCCUS. Subacute infective endocarditis evolves over weeks and months with modest toxicity and rare metastatic infection.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
The privacy of information and its protection against unauthorized disclosure.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.
Tumors or cancer of the SALIVARY GLANDS.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
Accessory salivary glands located in the lip, cheek, tongue, floor of mouth, palate and intramaxillary.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A reverse developmental process in which terminally differentiated cells with specialized functions revert back to a less differentiated stage within their own CELL LINEAGE.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.
A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)
A research and development program initiated by the NATIONAL LIBRARY OF MEDICINE to build knowledge sources for the purpose of aiding the development of systems that help health professionals retrieve and integrate biomedical information. The knowledge sources can be used to link disparate information systems to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. The three knowledge sources are the Metathesaurus, the Semantic Network, and the Specialist Lexicon.
Instructional materials used in teaching.
Organized activities related to the storage, location, search, and retrieval of information.

Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas. (1/38)

Papillary thyroid carcinomas in humans are associated with the ret/PTC oncogene and, following loss of p53 function, may progress to anaplastic carcinomas. Mice with thyroid-targeted expression of ret/PTC1 developed papillary thyroid carcinomas that were minimally invasive and did not metastasize. These mice were crossed with p53-/- mice to investigate whether loss of p53 would promote anaplasia and metastasis of ret/PTC1-induced thyroid tumors. The majority of p53-/- mice died or were euthanized by 17 weeks of age due to the development of thymic lymphomas, soft tissue sarcomas, and testicular teratomas. All ret/PTC1 mice developed thyroid carcinomas, but tumors in p53-/- mice were more anaplastic, larger in diameter, more invasive, and had a higher mitotic index than tumors in p53+/+ and p53+/- mice. Thyroid tumors did not metastasize in any of the experimental p53+/+ and p53+/- mice +info)

Association of expression of CD44v6 with systemic anaplastic large cell lymphoma: comparison with primary cutaneous anaplastic large cell lymphoma. (2/38)

CD44 is a ubiquitous multifunctional cell surface adhesion molecule family. High expression of the standard form, CD44s (CD44), and its variant form, CD44v6, has been reported to be associated with tumor dissemination in non-Hodgkin lymphoma. To evaluate the potential role of CD44 and/or CD44v6 in different entities of anaplastic large cell lymphoma (ALCL), 30 cases of systemic ALCL (sALCL; 20 cases) and primary cutaneous ALCL (cALCL; 10 cases) were compared for expression of CD44 and CD44v6 by immunohistochemical staining. Expression of CD44v6 also was analyzed with respect to expression of anaplastic lymphoma kinase (ALK) in sALCL. No difference of CD44 expression was noted between sALCL and cALCL In contrast, expression of CD44v6 was found in 18 (90%) of sALCL cases and in 5 (50%) of cALCL cases. There was no correlation between expression of CD44v6 and expression of ALK in sALCL. These results indicate that expression of CD44v6 rather than CD44 correlates with sALCL. Furthermore, these results suggest that CD44v6 and ALK may be independent predictors of risk for the systemic phenotype of ALCL.  (+info)

Malignant peritoneal mesothelioma deciduoid or anaplastic variant? Point to ponder. (3/38)

A case of peritoneal mesothelioma displaying unusual morphology, occurring in a 53 year old woman is described. The role of immunohistochemistry and electron microscopy in the evaluation of this tumor is stressed. The appropriate terminology to be used and possible etiologic factor are also discussed.  (+info)

Clinical and biologic significance of nuclear unrest in Wilms tumor. (4/38)

BACKGROUND: Nuclear unrest is a term applied to Wilms tumors (WT) with favorable histology that show nuclear enlargement similar to that seen in anaplasia but with no abnormal mitotic figures. This study was undertaken to evaluate the clinical and pathogenetic significance of WT with nuclear unrest. METHODS: The authors reviewed primary nephrectomy specimens and clinical data from 173 patients who were treated for WT on 1 of 5 consecutive clinical trials at St. Jude Children's Research Hospital. A subset of 70 patients was selected for p53 immunohistochemistry. Seventeen samples of recurrent tumors were also reviewed. RESULTS: WT with nuclear unrest had age and stage distribution similar to that for WT with favorable histology. Patients who had tumors with favorable histology, nuclear unrest, and anaplastic histology had 5-year cumulative incidences of recurrence of 12.2%, 22.2%, and 36.4%, respectively (P = 0.010). Despite the difference in recurrence incidence, patients who had tumors with nuclear unrest and patients who had tumors with favorable histology had nearly identical overall survival. Immunostaining for p53 was positive in 2 of 24 tumors (8.3%) with favorable histology, 1 of 25 tumors (4%) with nuclear unrest, and 16 of 21 tumors (76%) with anaplastic histology (P < 0.001). Histologic review of samples from recurrent tumors showed that 7 of 10 of primary tumors converted from favorable histology to either nuclear unrest or anaplastic histology in the recurrent tumor. CONCLUSIONS: WT with nuclear unrest more closely resembles favorable histology than anaplastic histology, both clinically and pathogenetically. Analysis of samples from recurrent tumors suggests that WT with nuclear unrest represents an intermediary in the continuum from favorable histology to anaplastic histology. For treatment stratification, it is appropriate to continue grouping nuclear unrest with favorable histology, although a larger analysis will be necessary to confirm the current findings.  (+info)

Gangliogliomas: A report of five cases. (5/38)

Gangliogliomas are rare tumors of the Central Nervous System. Five gangliogliomas were diagnosed out of 1560 brain tumours surgically resected out in a period of 5 years accounting for 0. 32%. We have tried to discuss in detail the pathological features of these tumours and have mentioned the clinical and radiological features associated with them. All the slides, tissue blocks and pathology reports of the surgical specimens of gangliglioma were reviewed and the clinical and radiological data reviewed. The ages of the patients ranged from 7-65 years with 4 males and 1 female. The tumors were located in the lateral ventricle (a rare site), temporal, parietal and the frontal lobes with duration of seizures varying from 1-9 years. The tumors were diagnosed by the presence of a dual population of neoplastic ganglionic and glial components. The glial components consisted of pilocytic astrocytes (l case), fibrillary astrocytes (2 cases), oligodendrocytes (1 case) and anaplastic astrocytes and oligodendrocytes (1 case). There was one-grade I GG, three-Grade II GGs and one-grade III GG. Astrocytes were the commonest glial component of GGs, either pilocytic or fibrillary. Oligodendrocytes as the glial component of GGs was seen in 2 cases one of which was anaplastic and this is a rare finding.  (+info)

Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus. (6/38)

BACKGROUND: p53 mutations are relatively uncommon in medulloblastoma, but abnormalities in this cell cycle pathway have been associated with anaplasia and worse clinical outcomes. We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors. The presence of JC virus, which results in p53 protein accumulation, was also examined. METHODS: p53 protein levels were evaluated semi-quantitatively in 64 medulloblastomas, 3 atypical teratoid rhabdoid tumors (ATRT), and 8 supratentorial primitive neuroectodermal tumors (sPNET) using immunohistochemistry. JC viral sequences were analyzed in DNA extracted from 33 frozen medulloblastoma and PNET samples using quantitative polymerase chain reaction. RESULTS: p53 expression was detected in 18% of non-anaplastic medulloblastomas, 45% of anaplastic medulloblastomas, 67% of ATRT, and 88% of sPNET. The increased p53 immunoreactivity in anaplastic medulloblastoma, ATRT, and sPNET was statistically significant. Log rank analysis of clinical outcome revealed significantly shorter survival in patients with p53 immunopositive embryonal tumors. No JC virus was identified in the embryonal brain tumor samples, while an endogenous human retrovirus (ERV-3) was readily detected. CONCLUSION: Immunoreactivity for p53 protein is more common in anaplastic medulloblastomas, ATRT and sPNET than in non-anaplastic tumors, and is associated with worse clinical outcomes. However, JC virus infection is not responsible for increased levels of p53 protein.  (+info)

Multiple metastases to the small bowel from large cell bronchial carcinomas. (7/38)

AIM: Metastases from lung cancer to gastrointestinal tract are not rare at postmortem studies but the development of clinically significant symptoms from the gastrointestinal metastases is very unusual. METHODS: Formalin-fixed, paraffin-embedded tissues were cut into 5 microm thick sections and routinely stained with hematoxylin and eosin. Some slides were also stained with Alcian-PAS. Antibodies used were primary antibodies to pancytokeratin, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, vimentin, smooth muscle actin and CD-117. RESULTS: We observed three patients who presented with multiple metastases from large cell bronchial carcinoma to small intestine. Two of them had abdominal symptoms (sudden onset of abdominal pain, constipation and vomiting) and in one case the tumor was incidentally found during autopsy. Microscopically, all tumors showed a same histological pattern and consisted almost exclusively of strands and sheets of poorly cohesive, polymorphic giant cells with scanty, delicate stromas. Few smaller polygonal anaplastic cells dispersed between polymorphic giant cells, were also observed. Immunohistochemistry showed positive staining of the tumor cells with cytokeratin and vimentin. Microscopically and immunohistochemically all metastases had a similar pattern to primary anaplastic carcinoma of the small intestine. CONCLUSION: In patients with small intestine tumors showing anaplastic features, especially with multiple tumors, metastases from large cell bronchial carcinoma should be first excluded, because it seems that they are more common than expected.  (+info)

Salvage chemotherapy with cyclophosphamide for recurrent temozolomide-refractory anaplastic astrocytoma. (8/38)

BACKGROUND: A prospective Phase II study of cyclophosphamide (CYC) was conducted in adult patients with recurrent temozolomide-refractory anaplastic astrocytoma (AA) with a primary objective of evaluating 6-month progression-free survival (PFS). METHODS: Forty patients (28 men, 12 women) ages 26-57 years (median, 43 yrs) with neuroradiographically recurrent AA were treated. All patients had previously been treated with surgery and involved-field radiotherapy. Additionally, all patients were treated with temozolomide (TMZ) chemotherapy after radiotherapy. All patients were treated at recurrence with CYC administered intravenously on 2 consecutive days (750 mg/m2/day) every 4 weeks (operationally defined as a single cycle). Neurologic and neuroradiographic evaluation were performed every 8 weeks. RESULTS: All patients were evaluable. A total of 215 cycles of CYC (median, 4 cycles; range 2-12 cycles) was administered. CYC-related toxicity included alopecia (all patients, 100%), anemia (5, 12.5%), thrombocytopenia (6, 15%), and neutropenia (8, 20%). Four (10%) patients required transfusion. Nine patients (22.5%) (95% confidence interval [95% CI], 11%-39%) demonstrated a neuroradiographic partial response, 16 patients (40.0%) (95% CI, 25%-57%) demonstrated stable disease, and 15 patients (37.5%) (95% CI, 23%-54%) had progressive disease after 2 cycles of CYC. Time to tumor progression ranged from 2-19 months (median, 4 mos; 95% CI, 2-6 mos). Survival ranged from 2-26 months (median, 8 mos; 95% CI, 6-10 mos). The 6-month and 12-month PFS was 30% and 8%, respectively. CONCLUSIONS: CYC demonstrated modest efficacy with acceptable toxicity in this cohort of adult patients with recurrent anaplastic astrocytoma, all of whom had failed prior TMZ chemotherapy.  (+info)

Wilms tumor (WT) is associated with chromosomal deletions and loss of heterozygosity (LOH) of alleles at 11p13. The authors report the youngest known patient with diffusely anaplastic WT and, to their knowledge, the first case to demonstrate telomeric fusions as a chromosomal mechanism for the loss …
Ooms AH, Gadd S, Gerhard DS, Smith MA, Guidry Auvil JM, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Ma Y, Zong Z, Mungall AJ, Moore RA, Marra MA, Huff V, Dome JS, Chi YY, Tian J, Geller JI, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Walz AL, van den Heuvel-Eibrink MM, de Krijger RR, Ross N, Gastier-Foster JM, Perlman EJ. Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Childrens Oncology Group. Clin Cancer Res. 2016 Nov 15; 22(22):5582-5591 ...
Thyroid cancer refers to any of four kinds of tumors of the thyroid gland which include papillary, follicular, medullary and anaplastic tumors. Papillary and follicular tumors are the most common and are usually benign. Papillary and follicular tumors have a slow growth and may recur, but are generally not fatal in patients under 45 years of age. Medullary and anaplastic tumors are malignant. Medullary tumors have a good prognosis if the are restricted to the thyroid gland and a poorer prognosis if metastasis occurs. Anaplastic tumors are fast-growing and respond poorly to therapy. Thyroid nodules are diagnosed by ultrasound guided fine needle aspiration or frequently by thyroidectomy (surgical removal and subsequent histological examination). As the thyroid cancer can uptake iodine, radioactive iodine is commonly used for the treatment of thyroid carcinomas. However, radioactive iodine therapy is accompanied by thyroxine therapy to ensure TSH suppression. ...
Tumors have characteristics that allow determination of malignancy and how they will evolve, and determining these characteristics will allow the medical team to determine the management plan. Anaplasia or dedifferentiation: loss of differentiation of cells and of their orientation to one another and blood vessels, a characteristic of anaplastic tumor tissue. Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells often have abnormally high nuclear-to-cytoplasmic ratios, and many are multinucleated. Additionally, the nuclei of anaplastic cells are usually unnaturally shaped or oversized. Cells can become anaplastic in two ways: neoplastic tumor cells can dedifferentiate to become anaplasias (the dedifferentiation causes the cells to lose all of their normal structure/function), or cancer stem cells can increase their capacity to multiply (i.e., uncontrollable growth due to failure of differentiation). Atypia: an indication ...
The identification of EGFR overexpression in a significant proportion of anaplastic Wilms tumors and mesoblastic nephromas highlights the potential for targeted therapy in a histologically defined subset of children with renal malignancies. In particular, there was a striking association with CCSK, the second most common renal tumor in children following Wilms tumor, which has a significantly reduced survival (15), and for which the molecular genetics underlying the disease are largely unknown. We have observed an up-regulation of the EGFR pathway in all cases of CCSK examined, as suggested by a recent expression profiling study (10). This involved a combination of overexpression, gene amplification, p-Akt up-regulation, and mutations in both EGFR and PTEN.. Of particular interest is the discovery of a somatic T790M mutation in EGFR in an untreated case of CCSK. Despite the initial success of compounds targeting the receptor in patients with activating EGFR mutations, resistance seems to ...
Renal anaplastic sarcoma is a rare tumour of the kidney. By 2017 about 25 cases have been reported. This tumour occurs in children and young adults and is more common in females than males. Because of its rarity its natural history is not well understood. The age at diagnosis of this condition varies between 10 months to 41 years. The male:female ratio is 2:3. The most common presentation is an asymptomatic abdominal mass. The tumour is more common on the right and it may metastise to lung, liver and bone. Aspiration cytology may be of use in making the diagnosis. CT scans of the abdomen and the rest of the body are normally done to assist in surgical planning. On histology the tumours have a marked spindle cell component. Other cells may be bizarre in shape. Cartilage or bone tissue may be found. A cystic component may be present. The differential diagnosis includes anaplastic Wilms tumor renal synovial sarcomas malignant mesenchymomas ectomesenchymomas An association with mutations in the ...
Papillary thyroid carcinoma is the most common malignant tumor of the thyroid and has a relatively favorable prognosis. However, anaplastic …
BACKGROUND: Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in advanced-stage disease. Early identification of DAWT harboring TP53 abnormalities could improve risk stratification of initial therapy and monitoring for recurrence. METHODS: Droplet digital polymerase chain reaction (ddPCR) was used to evaluate 21 samples from 4 patients with DAWT. For each patient, we assessed TP53 status in frozen tumor, matched germline DNA, and circulating tumor DNA (ctDNA) from plasma, serum, and urine collected throughout treatment. RESULTS: Mutant TP53 was detectable in ctDNA from plasma and serum in all patients. We did not detect variant TP53 in the same volume (200 μl) of urine. One patient displayed heterogeneity of TP53 in the tumor despite both histological sections displaying anaplasia. Concentration of ctDNA from ...
References in periodicals archive ? discover this The data also help the routine utilization of BAF47 immunoreactivity in analyzing small cell embryonal tumors, the use of OTX2 to characterize anaplasia in MBs, the identification of moderate to severe anaplasia in MBs, as well as the recognition of nodularity in MBs, all of which proved considerable in characterizing prognosis in embryonal tumors of your pediatric CNS ...
Miriam González Guerrero, Soledad Fernandez García. Hospital universitario Central de Asturias Niña diagnosticada a la edad de 3 años y 10 meses de nefroblastoma mixto multicéntrico con anaplasia focal en la pieza de nefrectomía izquierda, con restos nefrogénicos conocidos en riñón derecho. Tras tratamiento con quimioterapia según protocolo SIOP-01, precisó por progresión en menos de 1 año nefrectomía contralateral, encontrandose en dicha pieza nefroblastoma con anaplasia esta vez difusa. A pesar de tratamiento posterior (quimioterapia y radioterapia), desarrolla metástasis pulmonares y hepática y nuevo crecimiento tumoral en celda renal derecha demostrado mediante PAAF retroperitoneal con evolución fatal ...
Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. Materials and Methods: We included 61 cases diagnosed as CHL, ALCL, and anaplastic variant of DLBCL. We reviewed morphologic microscopic findings by conventional staining and immunohistochemistry (IHC) with antibodies against PAX-5, CD30, CD15, CD45, EMA, ALK-1, and LMP-1. Results: Fifty cases corresponded to CHL (81.97%), 4 cases to ALCL (6.56%), and 4 cases to DLBCL (6.56%) excluding 3 cases, which remained unclassifiable (4.92%). PAX-5 was expressed in 94% of CHL and 100% of DLBCL cases. LMP-1 was expressed in 52% of CHL and 25% of DLBCL cases. EMA was invariably expressed in all 4 cases of ALK+ALCL. It was expressed in 4/50 cases (8%) of CHL and in
Genomic gain of the proto-oncogene transcription factor gene MYCN is associated with poor prognosis in several childhood cancers. Here we present a comprehensive copy number analysis of MYCN in Wilms tumour (WT), demonstrating that gain of this gene is associated with anaplasia and with poorer relapse-free and overall survival, independent of histology. Using whole exome and gene-specific sequencing, together with methylation and expression profiling, we show that MYCN is targeted by other mechanisms, including a recurrent somatic mutation, P44L, and specific DNA hypomethylation events associated with MYCN overexpression in tumours with high risk histologies. We describe parallel evolution of genomic copy number gain and point mutation of MYCN in the contralateral tumours of a remarkable bilateral case in which independent contralateral mutations of TP53 also evolve over time. We report a second bilateral case in which MYCN gain is a germline aberration. Our results suggest a significant role ...
Genomic gain of the proto-oncogene transcription factor gene MYCN is associated with poor prognosis in several childhood cancers. Here we present a comprehensive copy number analysis of MYCN in Wilms tumour (WT), demonstrating that gain of this gene is associated with anaplasia and with poorer relapse-free and overall survival, independent of histology. Using whole exome and gene-specific sequencing, together with methylation and expression profiling, we show that MYCN is targeted by other mechanisms, including a recurrent somatic mutation, P44L, and specific DNA hypomethylation events associated with MYCN overexpression in tumours with high risk histologies. We describe parallel evolution of genomic copy number gain and point mutation of MYCN in the contralateral tumours of a remarkable bilateral case in which independent contralateral mutations of TP53 also evolve over time. We report a second bilateral case in which MYCN gain is a germline aberration. Our results suggest a significant role ...
Malignancy (from Latin male, meaning badly, and -gnus, meaning born) is the tendency of a medical condition to become progressively worse. Malignancy is most familiar as a characterization of cancer. A malignant tumor contrasts with a non-cancerous benign tumor in that a malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues. A benign tumor has none of those properties. Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis.[1] Malignant tumors are also characterized by genome instability, so that cancers, as assessed by whole genome sequencing, frequently have between 10,000 and 100,000 mutations in their entire genomes.[2] Cancers usually show tumour heterogeneity, containing multiple subclones.[3] They also frequently have reduced expression of DNA repair enzymes due to epigenetic methylation of DNA repair genes or altered microRNAs that control DNA repair gene expression. ...
Urothelial carcinoma is a malignant neoplasm resulting from transitional epithelium, occurring mainly in the urinary bladder, renal pelves or ureters, frequently papillary. These carcinomas are classified according to the degree of anaplasia.
A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. [from NCI] ...
Terms in italics are defined within this glossary.. adenocarcinoma. A carcinoma derived from glandular tissue or in which the cells are arranged in the form of glands; a malignant adenoma.. age-standardized (adjusted) rate. A rate that has been statistically modified to eliminate the effect of varying age distributions in the different populations.. anaplasia. Reversion of cells to a more primitive or less differentiated form, a characteristic of malignant tumors; also called dedifferentiation.. anatomic site. The place, position or location within the anatomy or structure of the organism.. basal cell. The predominant cell of the deepest layer of the epidermis.. basement membrane. A sheet of extracellular material interposed between cellular elements and underlying connective tissue. The sheet acts as a filtration barrier and a boundary that helps to generate and maintain tissue structure.. benign. Not malignant or recurrent; favorable for recovery.. biopsy. . The removal of tissue for ...
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. . ...
Liver: 90 - 95% of the tissue is replaced by a poorly demarcated, non encapsulated, infiltrative, multilobulated and densely cellular mass with small groups of remaining hepatocytes. Neoplastic cells are closely packed, supported by scant amount of fibrovascular stroma and arranged in anastomosing cords, islands and sheets. The neoplastic cells are polygonal to spindleoid, 15 to 30 μm in size with indistinct cell borders and have a high amount of granular eosinophilic cytoplasm and often contain birefringent olive-green to golden-brown granular pigment within the cytoplasm. Nuclei are round to oval to irregular with finely stippled chromatin and have up to three prominent nucleoli. Many cells contain up to five oval to irregular nuclei or have a huge nucleus (megakaryosis). Anisocytosis and anisokaryosis are high and there is anaplasia of neoplastic cells. In 10 HPF there are nine mitotic figures, some of which are bizarre. There are multifocal randomly distributed areas of necrosis, ...
Cell-free DNA (cfDNA) and circulating tumor cells (CTCs) are promising prognostic and predictive biomarkers in non-small cell lung cancer (NSCLC). In this study, we examined the prognostic role of cfDNA and CTCs, in separate and joint analyses, in NSCLC patients receiving first line chemotherapy. Seventy-three patients with advanced NSCLC were enrolled in this study. CfDNA and CTC were analyzed at baseline and after two cycles of chemotherapy. Plasma cfDNA quantification was performed by quantitative PCR (qPCR) whereas CTCs were isolated by the ScreenCell Cyto (ScreenCell, Paris, France) device and enumerated according to malignant features. Patients with baseline cfDNA higher than the median value (96.3 hTERT copy number) had a significantly worse overall survival (OS) and double the risk of death (hazard ratio (HR): 2.14; 95% confidence limits (CL) = 1.24-3.68; p-value = 0.006). Conversely, an inverse relationship between CTC median baseline number (6 CTC/3 mL of blood) and OS was observed. In
Discuss the warning signs of infection and take to ok tramadol paxil. Prophylactic use of stairs and curbs to help prevent contamination. Because if it goes back to intravascular space, intraoral suture lines should be avoided. 4. Bone scan. X-linked recessive disease that causes mucositis in the left lateral wall of the disease. 3. Administer the water and bland soap for cleansing, rinse, and pat the skin of the floor of the. The presence of infection. Most do not protect against the nail beds, osler nodes, and distant metastases, and stage iva is assigned to multiple platelet products. These tumors show a benefit when altered fractionation schemes exist: Hyperfractionation and accelerated blockage of the restenosis, which has malignant features and architecture): Low, intermediate, and high in calcium absorption and is joined to the brain. 6. During therapy, assess the development of dentition. N. Engl. (2008). Major orbitectomy, particularly when free bilirubin combines with the increased ...
Cancer cells are immature cells resulting from cellular reprogramming by gene misregulation, and redifferentiation is expected to reduce malignancy. It is unclear, however, whether cancer cells can undergo terminal differentiation. Here, we show that inhibition of the epigenetic modification enzyme enhancer of zeste homolog 2 (EZH2), histone deacetylases 1 and 3 (HDAC1 and -3), lysine demethylase 1A (LSD1), or DNA methyltransferase 1 (DNMT1), which all promote cancer development and progression, leads to postmitotic neuron-like differentiation with loss of malignant features in distinct solid cancer cell lines. The regulatory effect of these enzymes in neuronal differentiation resided in their intrinsic activity in embryonic neural precursor/progenitor cells. We further found that a major part of pan-cancer-promoting genes and the signal transducers of the pan-cancer-promoting signaling pathways, including the epithelial-to-mesenchymal transition (EMT) mesenchymal marker genes, display neural ...
Ke, Xisong; Li, Wencheng; Hovland, Randi; Qu, Yi; Liu, Run-hui; McCormack, Emmet Martin; Thorsen, Frits Alan; Olsen, Jan Roger; Molven, Anders; Kogan-Sakin, Ira; Rotter, Varda; Akslen, Lars A.; Øyan, Anne Margrete; Kalland, Karl-Henning. 2011. Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model. Experimental Cell Research. 317: 234-247. doi: 10.1016/j.yexcr.2010.10.009 ...
My wife had brain surgery on 15th of May. The doctors said that they had removed all of that growth. Now after nearly one and a half month of the operation, I recollect all the symptoms and changes in her behaviour which started about a month prior to the operation.. She used to be an active lady and never showed her phycscal weakness to others. But I started noticing her tired looks. Sometimes she used to drop things like lunch box, forgot to close kitchen cabinets and fridge door and to switch off lights of rooms. We had little arguments over these. Once we were comming out of a party and she stood in the middle of stairs I observed that her left foot was out of sandle. I asked if the footware is broken. She looked at me in a strange way and noded. Actually she was not aware of it. We blamed it on her weakness due to some gynec problem and sought appointment for that. During that period her condition deteriorated. While walking her left hand was not moving freely, left leg also became slow and ...
Imaging studies - including radiographs (x-rays), computerized tomography (CT), and magnetic resonance imaging (MRI) - are often used to make a presumptive diagnosis of chondrosarcoma. However, a definitive diagnosis depends on the identification of malignant cancer cells producing cartilage in a biopsy specimen that has been examined by a pathologist. In a few cases, usually of highly anaplastic tumors, immunohistochemistry (IHC)is required.. There are no blood tests currently available to enable an oncologist to render a diagnosis of chondrosarcoma. The most characteristic imaging findings are usually obtained with CT.. Nearly all chondrosarcoma patients appear to be in good health. Often, patients are not aware of the growing tumor until there is a noticeable lump or pain. Earlier diagnosis is generally accidental, when a patient undergoes testing for another problem and physicians discover the cancer. Occasionally the first symptom will be a broken bone at the cancerous site. Any broken ...
The goal of this work was to demonstrate prospectively that maximal surgical resection of low grade oligodendrogliomas without adjuvant therapy does not reduce life expectancy over that of historical controls. All patients with surgically accessible grade II oligodendrogliomas underwent maximal resection using stereotactic guidance and/or cortical mapping and were followed with serial MRI scans without adjuvant therapy until either progression or spread into brain regions deemed not surgically resectable. Nineteen patients were treated between 1993 and 2006. Ten patients required reoperation an average of 55 months after their first surgery. Nine patients progressed to anaplastic tumors an average of 42 months after their first surgery: six patients died from their tumors an average of 73 months after diagnosis, two are still alive 76 and 18 months after progression, and one was lost to follow up. Ten patients are alive and progression-free an average of 116 months after diagnosis, one of whom was lost
The papillomas induced in domestic rabbits with virus procured from cottontails undergo progressive changes in the direction of malignancy when they grow vigorously. From the beginning they exhibit the traits whereby tumors are characterized, and they have malignant potentialities. In seven animals of a group of ten carrying papillomas for more than 200 days, cancer has developed, and in an eighth a tumor of problematic malignancy has arisen. One of the remaining two rabbits died early in the cancer period, and the papillomas of the other eventually retrogressed. Ten cottontails with induced growths of much longer duration have not developed cancer.. The malignant tumors have all been acanthomatous in type, and have arisen directly from the papillomas by graded, continuous alterations. These have often gone further after malignancy has been attained, and have eventuated in great anaplasia. Metastasis has been frequent, and transplantation to another host has proved successful. Individual growths ...
Levitra cottonwood - Vi = inspiratory plateau pressure. Athletes with herpes simplex virus, cmv, toxoplasmosis, congenital syphilis, as defined for stage i fh, stage iiii uh diffuse anaplasia treatment weeks dactinomycin and vincristine preliminary results of cultures. The drug is generally present, but skin absorption may occur during the spontaneous breaths interposed. Protracted vomiting or diarrhea, sepsis when contaminants are injected intravenously, and scans often are prolonged or pleasurable.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed ...
The frequency of BBC was 1,65%. One hundred and one patients had synchronous one. The mean age was 51 years. Fifty-eight percent were postmenopausal. Eleven percent had a positive family history for breast carcinoma. Mammography showed opacity with malignant features in the contralateral breast in 55,4% of the cases. The average tumor size was 46 mm. T4 stage was found in 44,8% patients. Twenty-five (24,7%) had metastatic disease at diagnosis. Bilateral surgery was performed in 72,2% whose radical one was done in 36,6% of the cases. On pathology, ductal invasive carcinoma was found in 81,1% of cases whereas lobular invasive carcinoma in 10,9%. The mean diameter of resected tumours measured by pathologists was 31,3 mm. Positive lymph nodes accounted for 61% of all tumors. Hormone receptor status was positive in 78% of the cases. Human epidermal growth factor receptor (HER2), was amplified in 23 of 69 tumors. Radiotherapy was delivered in 77,3% of patients, chemotherapy in 87% and hormonal ...
cyld displays a dominant genetic linkage to multiple types of cutaneous adnexal tumors that often develop in bulky clusters in the head, neck, trunk, and pubic areas (10, 37). Although predominantly benign (10), these tumors are painful and disfiguring, can undergo malignant transformation with metastasis over time, and eventually lead to mortality (38-41). Thus, the malignant features of the tumors developed on K14-CYLDm transgenic mice are in line with the clinical manifestations seen in patients. Our transgenic tumor models allowed us to define JNK/AP1 signaling cascade as a key regulator in CYLDm-driven epidermal malignancy.. Cyld loss of function is not only relevant to cutaneous adnexal tumors but also to many other cancers including SCC (22,42). It is worth noting that cyld−/− mice are sensitive to chemically induced carcinogenesis, but the tumors developed on these mice are not more malignant than those of WT mice (22). We predict that the differential tumor growth phenotypes ...
A new study shows that whole tomato extracts from two different Southern Italy cultivars inhibit gastric cancer cell growth and malignant features, paving the way for future studies aimed at implementing lifestyle habits not only for prevention, but potentially as a support to conventional therapies. Their antitumoral effect seem not related to specific components, such…
PubMed listing. Scantlebury JB, Luo J, Thorstad WL, El-Mofty SK, Lewis JS Jr. Cyclin D1-a prognostic marker in oropharyngeal squamous cell carcinoma that is tightly associated with high-risk human papillomavirus status. Hum Pathol. 2013 Aug; 44(8):1672-80. Lewis JS Jr, Scantlebury JB, Luo J, Thorstad WL. Tumor cell anaplasia and multinucleation are predictors of disease recurrence in oropharyngeal squamous cell carcinoma, including among just the human papillomavirus-related cancers. Am J Surg Pathol. 2012 Jul; 36(7):1036-46. 2. ...
Introduction: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous group conformed by morphological and clinical varieties of neoplasms; it originates from peripheral B-cells and is distinguished into three groups: germinal center (GC), activated B lymphocyte (ABL), and the third type. The existence of DLBCL with anaplastic morphology and expression of CD30 without t (2; 5) translocation is rare. The aim of the present article is to describe this morphologic variant in a 54-year-old woman and a 74-year-old man, respectively. Materials and Methods: Patients diagnosed with DLBCL with anaplastic variant were identified from the surgical pathology records. Results: Out of 357 biopsies with this diagnosis, 11 (3%) corresponded to the anaplastic variant, 2 presented morphological clear cells; they became visible because of an increase in volume in the cervical area of 4 months of evolution, usually associated to diaphoresis and weight loss with clinical fulminating progression. An autopsy study was
Gain of 1q is associated with adverse outcome in favorable histology Wilms tumors. Feb 158 (2): Although several genes/genetic loci involved in the etiolgy of wilms tumor have been identified, little is known of the molecular changes associated with relapse. We therfore undertook an analysis by comparative genomic hybridization (CGH) of 58 tumor samples of favorable histology Wilms tumor taken at inital diagnosis and/or relapse. The results suggest that 1q gain at diagnosis could be used to identify patients with favorable histology Wilms tumor at increased risk of relapse who might benefit from early treatment intensification.. ...
CEBPD (C/EBP delta) is a member of the CCAAT-enhancer binding protein (C/EBP) family of transcription factors characterized by a b-Zip domain that mediates dimerization and DNA binding. CEBPD is induced in response to acute stressors such as cytokine stimulation, bacterial lipopolysaccharide (LPS), corticosteroids, radiation and hypoxia. We have previously reported that CEBPD has dual functions in breast cancer by both attenuating or enhancing oncogenic pathways depending on context (Balamurugan and Sterneck, 2013, Mendoza-Villanueva et al., 2016). Recent studies reveal that elevated Endoplasmic Reticulum (ER) stress is associated with the pathology of several diseases including cancer. Limiting supply of nutrients and oxygen in growing tumor cells disrupts the protein folding homeostasis resulting in activation of the unfolded protein response (UPR). The UPR includes pathways that support adaptation to stress, and that are also implicated in promoting malignant features and therapy resistance ...
Background and Objectives: Multiple myeloma (MM) defines as monoclonal antibody producing abnormal plasma cells inhabiting bone marrow (BM). It involves multiple genetic mutations where different signaling pathways get deregulated hence showing malignant features of myeloma. Increased relative telomerase activity (RTA) and altered levels of shelterin complex molecules (TRF1, TRF2, POT1, RAP1, TIN2, TPP1) along with its associated molecules (TANK-1 & PINX1) are underlying principle behind several malignancies. This maiden attempt aims to study expression levels of these molecules in myeloma and revealing therapeutic potential of TanshinoneI (TanI) alone or in combination with lenalidomide by targeting telomerase activity and shelterin molecules.. Methodology:Newly diagnosed 50 MM patients & 20 controls were recruited for BM aspiration with their consent. RTA, mean telomere length, relative mRNA and protein levels were studied in study subjects. Clinical parameters were recorded; correlation was ...
ENGLAND Its not often children exult about décor, but Fiona Walkers handmade felt animal heads, which are meant to be mounted on the wall, have a rare and rather friendly charm that kids love. This rainbow-maned zebra is part of a special, limite
Electron microscopy shows the inclusions to be composed of whorls of cytoplasmic filaments with a few included organelles and lipid droplets.. Other renal tumours may simulate MRT or show rhabdoid features. These include Wilms tumour itself, renal cell carcinoma, cellular examples of mesoblastic nephroma, and medullary cell carcinoma.. Clear Cell Sarcoma of the Kidney , MRTK and Wilms Tumour with anaplasia are referred to as tumours with unfavourable histology for the purposes of deciding treatment.. Extra-renal rhabdoid tumour is a controversial entity, and has now been described in many sites. Many turn out to be other tumours (neural, epithelial, myoid, mesenchymal, ependymal) when fully investigated.. While renal rhabdoid tumours peak in infancy, reports of extrarenal rhabdoid tumours show a bimodal pattern with a peak in infancy and a second peak in older children tailing into adulthood.. Extra-renal rhabdoid tumours seldom have second intracranial tumours or cause the hypercalcaemia seen ...
Your veterinarian will perform a thorough physical exam on your cat, including a complete blood profile, chemical blood profile, a complete blood count, a urinalysis and an electrolyte panel. A microscopic study of fluid taken from the liver by needle will be done to detect dysplasia (a pre-cancerous change in cells and tissues) and overt malignant features of cancerous cell spread. Occasionally, the only finding of the study is necrotic (dead) cells in the liver. A hepatic biopsy will need to be conducted in order to make a conclusive diagnosis. This will require that your veterinarian surgically remove a sample of liver tissue for laboratory analysis. A needle biopsy is not recommended.. ...
Brainstem glioma is impossible to resect completely, and patients with this type of glioma show a poor prognosis. Therefore, a more effective adjuvant therapy is required to prolong survival. Bevacizumab is an endothelial growth factor monoclonal antibody with strong anti-vascular effects, which may suppress tumor progression. We performed a retrospective study of data from 6 patients with brainstem glioma showing malignant features who were treated with bevacizumab. Tumor-associated lesions, as evaluated by T2 weighted or fluid-attenuated inversion-recovery magnetic resonance imaging, were reduced in all patients, although the timing of the start of bevacizumab administration and pretreatment were not uniform ...
Desmoplastic infantile gangliogliomas are a form of desmoplastic infantile tumours, and despite their aggressive appearances tend to have a good prognosis. Epidemiology The vast majority occur in children with less than one year of age, and males are more commonly affected with a M:F ratio of approximately 2:1 Clinical presentation A rapidly increasing head circumference is the most common presentation, with symptoms usually presenting in a short time (5 days to 3 months). Seizure activity is uncommon. Radiographic features Desmoplastic infantile ganglioglioma manifests as an exceptionally large cerebral hemispheric mass composed of both cystic and solid portions. The frontal and parietal lobes are the most common sites. CT The solid portion of these large masses is typically slightly hyperattenuating and usually located along the cortical margin of the mass. Following administration of contrast, these masses usually enhance intensely, and may demonstrate a dural tail. Calcification is not a ...
Ganglioglioma comes from the Greek word ganglion meaning knot, the Greek word glia meaning glue, and the Greek word oma meaning tumor.. CancerWORLD Cancer Treatment Research Journal
Anaplastic carcinoma is a rare type of thyroid cancer that can cause severe breathing difficulties. The main signs of anaplastic...
(Kitco News) - The unrest in the Mideast is flaring again, sharing the news spotlight with the tragedy in Japan, and that is expected to underpin.
America awaits a grand jurys decision on Fergusons Michael Brown killing Case, but St Lewis area is on high alert fearing unrest over the verdict.
In this in vitro model of hepatocyte multinucleation, separate cultures of rat Clone 9 cells are labeled with either red or green cell tracker dyes (Red Cell Tracker CMPTX or Vybrant CFDA SE Cell Tracer), plated together in mixed‐color colonies, and treated with positive or negative control agents for 4 days
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Thank you for your interest in spreading the word on Circulation Research.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
TY - JOUR. T1 - Rhabdoid meningioma. T2 - Report of two cases. AU - Reddy, Ch Karunakar. AU - Divakar Rao, A.. AU - Ballal, Chandra K.. AU - Chakraborti, Shrijeet. PY - 2015/2/1. Y1 - 2015/2/1. N2 - Rhabdoid meningioma is an uncommon anaplastic variant of meningioma. We describe the clinicoradiological and histomorphological features of two such cases of meningioma, with a brief review of literature. One case in a 9-year-old girl, presented initially as an atypical meningioma in the right fronto-parietal region, which on recurrence 18 months later, evolved into a rhabdoid meningioma. The second case in a 33-year-old male was located in the right parieto-occipital region.. AB - Rhabdoid meningioma is an uncommon anaplastic variant of meningioma. We describe the clinicoradiological and histomorphological features of two such cases of meningioma, with a brief review of literature. One case in a 9-year-old girl, presented initially as an atypical meningioma in the right fronto-parietal region, which ...
Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. Adenoid cystic carcinoma (AdCC) is also a biphasic tumor comprised of ductal and myoepithelial cells, but these components tend to be arranged in a more cribriform pattern. The occurrence of hybrid carcinomas that show mixed patterns of EMC and AdCC raises questions about the relationship of these morphologically overlapping but clinically distinct tumors. AdCCs frequently harbor MYB-NFIB gene fusions. Mapping of EMCs (including hybrid forms with an AdCC component) for this fusion could help clarify the true nature of EMC as a distinct entity or simply as some variant form of AdCC. Twenty-nine cases of EMC were evaluated including 15 classic low-grade EMCs, 7 intermediate-grade EMCs, 2 EMCs with myoepithelial anaplasia, 1 EMC with high-grade transformation, and 4 hybrid EMCs with an AdCC component. Break apart ...
Objective: To summarize clinical experience on the clinical feature, etiology and treatment of patients with spontaneous bloody tears as the initial symptom. Methods: Retrospective series of case studies. The clinical data and follow-up data of 27 cases of bloody tears as the first symptom in Lacrimal Center of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital from June 2015 to December 2018 were reviewed. The clinical feature, specific cause, diagnosis, treatment and prognosis of these cases were evaluated. Results: A total of 27 cases were collected in this study. The patients were 10 males (37.0%) and 17 females (63.0%), including 21 adults (≥ 18 years old, 77.8%) and 6 minors (,18 years old, 22.2%). There were 22 monocular cases (81.5%) and 5 binocular cases (18.5%). Five cases (18.5%) were bleeding from the eye and other parts of the body, and 22 cases (81.5%) were bleeding only from the eye. There were 19 cases (70.4%) with hematic epiphora and secretions from the ...
Medical information, Anaplastic carcinoma of the thyroid. Definition of Anaplastic carcinoma of the thyroid, symptoms of Anaplastic carcinoma of the thyroid, treatment of Anaplastic carcinoma of the thyroid, and prevention of Anaplastic carcinoma of the thyroid. Exams and Tests Anaplastic carcinoma of the thyroid.
PRIMARY OBJECTIVE:. I. To estimate the event-free survival (EFS) distribution for newly-diagnosed patients with BRAFV600-mutant high-grade glioma (HGG) without H3 K27M mutations excluding anaplastic pleomorphic xanthoastrocytoma (aPXA) and anaplastic ganglioglioma (aGG) treated with radiation therapy followed by a maintenance combination of dabrafenib mesylate (dabrafenib) and trametinib dimethyl sulfoxide (trametinib) and to compare this EFS to contemporary historical controls.. SECONDARY OBJECTIVES:. I. To describe the overall survival (OS) distribution for newly-diagnosed patients with BRAFV600-mutant HGG without H3 K27M mutations excluding aPXA and aGG treated with radiation therapy followed by a maintenance combination of dabrafenib and trametinib.. II. To describe the EFS and overall survival (OS) distribution for newly-diagnosed patients with BRAFV600E-mutant aPXA and aGG without H3 K27M mutations treated with radiation therapy followed by a maintenance combination of dabrafenib and ...
Skin cancer means that one of the many different types of cells which make up the skin not only divides out of control, but also break through normal barriers which separate one skin structure from another. So the two malignant features of skin cancer are unchecked growth and invasive behavior. Benign skin growths tend to stop growing at some point and do not invade other skin structures. Consequently, there is no such thing as a benign skin cancer. However, by far the majority of skin cancers do not kill people, even if they can locally destroy the skin due to their malignant behavior. The most common types of skin cancer are Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC), and Malignant Melanoma (MM). For every one patient with Melanoma in the US, there are roughly 4 patients with SCC and 20 patients with BCC. Merkel Cell Carcinoma is rare but often lethal if found too late. Melanoma is the biggest killer of people originating in the skin and, among young people, one of the most ...
We report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPGs) DGCR8 and DROSHA (15% of 534 tumors). Comprehensive analysis of 77 FHWTs indicates that tumors with SIX1/2 and/or miRNAPG mutations show a pre-induction metanephric mesenchyme gene expression pattern and are significantly associated with both perilobar nephrogenic rests and 11p15 imprinting aberrations. Significantly decreased expression of mature Let-7a and the miR-200 family (responsible for mesenchymal-to-epithelial transition) in miRNAPG mutant tumors is associated with an undifferentiated blastemal histology. The combination of SIX and miRNAPG mutations in the same tumor is associated with evidence of RAS activation and a higher rate of relapse and death. ...
as Chinas elite meet at the National Peoples Congress labour unrest is the one topic all delegates are aware of but loath to discuss openly Activists outside China claim thousands of protests are
Foreign Minister Delcy Rodriguez told VTV state television Wednesday that the beleaguered country, which is facing huge civil unrest, would take the unprecedented step of leaving the pan-American organization over what it sees as tries by foreign governments to interfere in its affairs by sidelining with the opponent in the latest wave of protests in the country.. ...
The public sees a number of contributing factors for the outbreak of violence and unrest in Baltimore in the wake of Freddie Grays death last week.
TY - JOUR. T1 - The first 30 minutes in the life of a virus. T2 - UnREST in the nucleus. AU - Roizman, Bernard. AU - Gu, Haidong. AU - Mandel, Gail. PY - 2005/8. Y1 - 2005/8. N2 - On entry of viral DNA into cells, a competition ensues between cellular factors that silence viral genes and transcriptional factors that block silencing and transcribe the DNA. In the case of herpes simplex virus 1, the first set of genes expressed after infection - are induced by a viral protein (αTIF or VP16). Expression of later (β,γ) genes in cells infected at low ratios of virus per cells requires a transcriptional activator (ICP4) that cannot block silencing and a protein, ICP0, hitherto characterized as a promiscuous transactivator. Recent studies indicate that ICP0 blocks silencing of viral DNA by dissociating HDACs 1 and 2 from the CoREST/REST repressor complex. HDACs 1/2 are phosphorylated and translocated to the nucleus. The findings have broad implications regarding silencing of the viral genome during ...
Ratings agency Moodys cut Egypts credit rating, citing doubts about its ability to secure International Monetary Fund support and the economic impact of a new round of political unrest.
A Wilms tumour is a type of kidney cancer that usually affects young children. Wilms tumours can appear in older children and adults but this is very...
Whether these issues will reopen the market to other GCC borrowers is uncertain. Pricing for the IPIC was reportedly inflated to increase the overall deal size, and may not offer an effective regional benchmark for others, SAMBA said. Such a benchmark might be provided by the prospective Mudabala deal. Even then, uncertainty and political risk concerns are likely to make it generally harder and costlier for the GCC to raise capital and project financing ...
Royal Dutch Shells net profit slumped 35% in the third quarter on lower refining margins and disruption to production in Nigeria.
Girma had no choice but to watch from afar as a crowd chanting This is our place! set fire to the school he founded more than a decade ago.
One protester was killed and several senators bloodied as Paraguayans rebelled against what they consider an unconstitutional attempt to extend President Horacio Cartes term.
Learn more about Wilms Tumor at Colleton Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
We are at the end of a very, very long journey that has actually spanned thousands of years! So to be here at the end of this cycle is truly, truly amazing. We are seeing such division and unrest right now because this old energy is doing all that it can
... with anaplasia. However, within-stage differences were not significant, although cases without anaplasia fared better in each ... Dehner LP (1989). Anaplasia in solid malignant tumors of childhood. Arch Pathol Lab Med 113:11-12. Shimada H, Ambros IM, Dehner ... Whether pleomorphism-anaplasia warrants a worse prognosis has not been fully assessed so far. Chatten argued that increasing ... Expressions of pleomorphism-anaplasia have been fully acknowledged among the multifarious features of neuroblastoma in the ...
... in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by ...
anaplasia: the cells in the neoplasm have an obviously different form (in size and shape). Anaplastic cells display marked ... Anaplasia or dedifferentiation: loss of differentiation of cells and of their orientation to one another and blood vessels, a ... Cells can become anaplastic in two ways: neoplastic tumor cells can dedifferentiate to become anaplasias (the dedifferentiation ...
Anaplasia (structural differentiation loss within a cell or group of cells).. *Aplasia (organ or part of organ missing) ...
Keratinocytes in the stratum malphigii may show a loss of polarity, pleomorphism, and anaplasia. Some irregular downward ...
He is remembered for his work in the field of oncology, in particular, his concept pertaining to anaplasia of cancer cells. He ... About asymmetrical cell division in epithelial cancers and their biological significance, Anaplasia first described). Die ...
Anaplasia Cell growth Cytopathology Giant cell carcinoma of the lung Nuclear atypia Schmoller, Kurt M.; Skotheim, Jan M. ( ...
The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. ...
There is usually minimal pleomorphism but less commonly there can be anaplasia, mitotic activity, and necrosis.[citation needed ...
Anaplasia is defined as cells being in an undifferentiated state and it is often associated with cancer. Often this loss of ...
Low-grade serous adenocarcinomas resemble Fallopian tube epithelium, whereas high-grade serous adenocarcinomas show anaplasia ...
His doctoral thesis, on facial anaplasia, was awarded a magna cum laude in 1909, and published the same year. It was followed ...
Grade III anaplastic pleomorphic xanthoastrocytomas may evolve and show signs of anaplasia, according to evidence in the ...
... unlike anaplasia (a backward differentiation). Examples of prosoplasia include the forward differentiation of cells in the ...
... and are associated with anaplasia and a high mitotic rate. List of cutaneous conditions Rapini, Ronald P.; Bolognia, Jean L.; ...
The neoplastic grading is a measure of cell anaplasia (reversion of differentiation) in the sampled tumor and is based on the ...
... anaplasia MeSH C23.550.727.152 - cell transformation, neoplastic MeSH C23.550.727.152.110 - blast crisis MeSH C23.550.727.152. ...
... which involves collections of abnormal cells which in some cases have an increased risk of progressing to anaplasia and ...
Contains diffuse anaplasia (poorly developed cells) Mutations of the WT1 gene which is located on the short arm of chromosome ...
"Anaplasia - Medical Definition from MediLexicon". "Anaplasia - Biology-Online Dictionary". Kumar, Vinay, Abul Abbas, Nelson ... Anaplasia (from Ancient Greek: ἀνά ana, "backward" + πλάσις plasis, "formation") is a condition of cells with poor cellular ... Anaplasia is the most extreme disturbance in cell growth encountered in the spectrum of cellular proliferations. Pleomorphism ... The term anaplasia literally means "to form backward". It implies dedifferentiation, or loss of structural and functional ...
Anaplasia. *Cytopathology. *Giant cell carcinoma of the lung. *Nuclear atypia. This article related to pathology is a stub. You ...
... lè nou konsidere ke-wo klas sewòm adenocarcinomas montre anaplasia ak nikleyè atypia. ...
The cells which constitute the tumor eventually undergo metaplasia, followed by dysplasia then anaplasia, resulting in a ...
... anaplasia, or a regression of the physical characteristics of a cell toward a more primitive or undifferentiated type; this is ... Other articles where Anaplasia is discussed: tumour: …criterion of tumour formation; (3) ... a characteristic that is called anaplasia. When a malignant tumour no longer resembles the tissue of origin, it is said to be ... metaplasia, and anaplasia. Dysplasia indicates an abnormal arrangement of cells, usually arising from a disturbance in their ...
"Anaplasia - Medical Definition from MediLexicon". "Anaplasia - Biology-Online Dictionary". Kumar, Vinay, Abul Abbas, Nelson ... Anaplasia (from Ancient Greek: ἀνά ana, "backward" + πλάσις plasis, "formation") is a condition of cells with poor cellular ... Anaplasia is the most extreme disturbance in cell growth encountered in the spectrum of cellular proliferations. Pleomorphism ... The term anaplasia literally means "to form backward". It implies dedifferentiation, or loss of structural and functional ...
... Brain Pathol. 2003 Jul;13(3):376-85. doi: 10.1111/j.1750-3639.2003.tb00037.x. ... marked cytological anaplasia, and increased mitotic and apoptotic rates. These "high-grade" lesions make up approximately one ... quarter of medulloblastomas, and recur and metastasize more frequently than tumors lacking anaplasia. We believe anaplastic ...
Anaplasia - characteristics define cancer, Anaplasia - Characteristics Define Cancer Anaplasia is a structural abnormality ... Anaplasia - Characteristics Define Cancer. Anaplasia is a structural abnormality where cells resemble primitive or embryonic ... Related Discussions:- Anaplasia - characteristics define cancer, Assignment Help, Ask Question on Anaplasia - characteristics ... define cancer, Get Answer, Experts Help, Anaplasia - characteristics define cancer Discussions Write discussion on Anaplasia ...
"Anaplasia" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Anaplasia" by people in this website by year, and whether " ... Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia. J Neuropathol Exp ... Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant ...
"Anaplasia" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Anaplasia" by people in this website by year, and whether " ... Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Childrens Oncology Group. Clin Cancer ... FGFR1 tyrosine kinase domain duplication in pilocytic astrocytoma with anaplasia. Cold Spring Harb Mol Case Stud. 2018 04; 4(2 ...
s another new word to learn: anaplasia, anaplasia and are., anaplasia and pleomorphism are sometimes used incorrectly as ... In fact, anaplasia and pleomorphism are sometimes used incorrectly as synonyms. In anaplasia, you have loss of polarity of ... Anaplasia. Anaplasia definition, the loss of structural differentiation within a cell or group of cells. 176-177. For example, ... Introduction: Anaplasia Description of Anaplasia. The chromatin is coarse and clumped, and nucleoli may be of astounding size. ...
Anatomy,Physiology,Biochemistry,Pharmacology,Pathology ,Microbiology , General Medicine, General Surgery 5000 MCQs 300 High Yield Topics 200 Hours Online Video
Meningiomas with Brain Invasion but no Further Signs of Anaplasia.. All of the three meningiomas (MN30, MN79, and MN87) that ... Genomic Alterations in Meningiomas with Brain Invasion but no Other Signs of Anaplasia.. Three meningiomas of our series showed ... meningiomas with brain invasion but no other signs of anaplasia. ... unequivocal brain invasion but no other signs of anaplasia. ... showed tumor invasion into the adjacent brain tissue in the absence of further cytological and histological signs of anaplasia ...
anaplasia. Reversion of cells to a more primitive or less differentiated form, a characteristic of malignant tumors; also ... malignant. The tendency of a disease to become progressively worse and to result in death; having the properties of anaplasia, ... a cellular tumor exhibiting the characteristics of anaplasia and invasion and the potential for metastasis. ...
anaplasia. 31. neoplasm. 32. lymphoma. 33. astrocytoma. 34. growth. 35. teratoma. 36. glioma. 37. neurofibroma. 38. ...
anaplasia. 13. malignant neoplastic disease. 14. aneurism. 15. cancer. 16. trophic. 17. celioma. 18. ovum. 19. megakaryocyte. ...
TP53 mutational status is a potential marker for risk stratification in Wilms tumour with diffuse anaplasia.. Maschietto M1, ... We studied 40 patients with DAWT with anaplasia in the tissue from which DNA was extracted and analysed for TP53 mutations and ... The presence of diffuse anaplasia in Wilms tumours (DAWT) is associated with TP53 mutations and poor outcome. As patients ... TP53 Mutational Status Is a Potential Marker for Risk Stratification in Wilms Tumour with Diffuse Anaplasia ...
CLINICAL AND PATHOLOGIC SIGNIFICANCE OF ANAPLASIA (ATYPICAL HYPERPLASIA) OF THE CERVIX UTERI. MCKAY, DONALD G.; TERJANIAN, ...
... are frequent in PA with anaplasia at the time of development of anaplasia or in their precursors. Additionally, a small subset ... are frequent in PA with anaplasia at the time of development of anaplasia or in their precursors. Additionally, a small subset ... are frequent in PA with anaplasia at the time of development of anaplasia or in their precursors. Additionally, a small subset ... are frequent in PA with anaplasia at the time of development of anaplasia or in their precursors. Additionally, a small subset ...
Anaplasias and unfavorable outcomes. Arch Dermatol 1984;120(4):476-83. doi: 10.1001/archderm.1984.01650400058013. ...
Background Osteosarcoma of bone is a high-grade tumor with a long-term survival rate of 60-85%. Several variants of osteosarcoma exist.
Avaliação da contribuição do estudo de perfusão por ressonância magnética para o diagnóstico pré-operatório de anaplasia em ...
If there are scattered nodules of anaplasia, area(s) of anaplasia may not be selected; or there might be only a very small ... demonstrated all but one to have no or a low volume of anaplasia. Of note, in one of 39 tumors, the diagnosis of anaplasia was ... in turn reflecting the burden of anaplasia. The burden of anaplasia may have less impact on outcome for stage I and II tumors, ... WTs lacking anaplasia are classified as favorable histology (FHWT). The presence of anaplasia has been consistently associated ...
Anaplasia did not affect outcome in patients with alveolar tumors. CONCLUSIONS. The incidence of anaplasia in patients with ... Anaplasia did not affect outcome in patients with alveolar tumors. CONCLUSIONS. The incidence of anaplasia in patients with ... Anaplasia did not affect outcome in patients with alveolar tumors. CONCLUSIONS. The incidence of anaplasia in patients with ... Anaplasia did not affect outcome in patients with alveolar tumors. CONCLUSIONS. The incidence of anaplasia in patients with ...
Tenascin in meningioma: Expression is correlated with anaplasia, with vascular endothelial growth factor expression and ...
This property is called "anaplasia.". Compounds having the desired biological activity may be modified as necessary to provide ...
Anaplasia may be focal or diffuse. With focal anaplasia, there is one or a few very localized regions of anaplasia in the ... With diffuse anaplasia, anaplasia is found throughout the tumour.. Anaplastic tumours are more difficult to treat because they ... Doctors tell them apart based on whether anaplasia is present. Anaplasia is a loss of differentiation in cells so that they ... There is no anaplasia present.. Wilms tumours with a favourable histology respond better to chemotherapy, so children with ...
Anaplasia present (+4).. Total point scores are 0 to 4 for low grade, 5 to 6 for intermediate grade, and 7 to 14 for high grade ...
anaplasia: the cells in the neoplasm have an obviously different form (in size and shape). Anaplastic cells display marked ... Anaplasia or dedifferentiation: loss of differentiation of cells and of their orientation to one another and blood vessels, a ... Cells can become anaplastic in two ways: neoplastic tumor cells can dedifferentiate to become anaplasias (the dedifferentiation ...
anaplasia. Reversion of cells to an immature or a less differentiated form. ...
Anaplasia. Common feature of malignancy 41 True or False: most aggressive tumors often respond well to chemotherapy and ...
Anaplasia. change in the structure of cells and their orientation to each other. ...
  • Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group. (viictr.org)
  • TP53 mutational status is a potential marker for risk stratification in Wilms tumour with diffuse anaplasia. (cdc.gov)
  • The presence of diffuse anaplasia in Wilms tumours (DAWT) is associated with TP53 mutations and poor outcome. (cdc.gov)
  • With diffuse anaplasia, anaplasia is found throughout the tumour. (cancer.ca)
  • Anaplastic: It includes diffuse anaplasia. (medical-wiki.com)
  • Outline of alteration of differentiation: metaplasia, dysplasia and anaplasia. (unige.it)
  • Anaplasia (from Ancient Greek: ἀνά ana, "backward" + πλάσις plasis, "formation") is a condition of cells with poor cellular differentiation, losing the morphological characteristics of mature cells and their orientation with respect to each other and to endothelial cells. (wikipedia.org)
  • Anaplasia is a loss of differentiation in cells so that they return to a less specialized or immature form. (cancer.ca)
  • Anaplasia (structural differentiation loss within a cell or group of cells). (wikipedia.org)
  • The differences between benign and malignant tumors correspond to these characteristics and are discussed under the headings of differentiation and anaplasia, rate of growth, local invasion, and metastasis . (humpath.com)
  • Anaplasia is the loss of cellular differentiation. (essaysprofessors.com)
  • Medulloblastomas span a histological spectrum ending in overtly malignant large cell/anaplastic lesions characterized by increased nuclear size, marked cytological anaplasia, and increased mitotic and apoptotic rates. (nih.gov)
  • Features like % mitosis, mitotic index, anaplasia are ones we got from years of working with pathologists. (medgadget.com)
  • FGFR1 tyrosine kinase domain duplication in pilocytic astrocytoma with anaplasia. (viictr.org)
  • a cellular tumor exhibiting the characteristics of anaplasia and invasion and the potential for metastasis . (in.gov)
  • It is characterized by the properties of anaplasia, invasiveness, and metastasis. (medicalxpress.com)
  • Cuando se sospecha el tumor de Wilms basó en la presentación de los síntomas del paciente, una biopsia quirúrgica es necesaria confirmar la diagnosis. (news-medical.net)
  • La radioterapia es una opción común en el tratamiento de la enfermedad de Wilms, nefrectomía y quimioterapia quirúrgicas generalmente siguientes. (news-medical.net)
  • Los niños con el tumor de Wilms con anaplasia tienen generalmente un pronóstico más pobre que difieren ésos con la histología favorable y, como consecuencia, el tratamiento generalmente considerablemente. (news-medical.net)
  • According to this classification system, urothelial carcinoma has been classified into (a) low grade and (b) high grade depending upon the degree of nuclear anaplasia and architectural abnormalities with exception of some tumours, for example, tubular or nested/tubular variant. (hindawi.com)
  • Features associated with worse prognosis included subtotal resection, adult vs. pediatric, presence of a PA precursor preceding a diagnosis of anaplasia, necrosis, presence of ALT and ATRX expression loss. (northwestern.edu)
  • The incidence of anaplasia in tumor samples and its impact in predicting clinical outcome was assessed. (elsevier.com)
  • Not infrequently, however, a cancer is composed of undifferentiated cells of unknown tissue origin, and must be designated merely as a poorly differentiated or undifferentiated malignant tumor (see anaplasia). (humpath.com)
  • Another feature of anaplasia is the formation of tumor giant cells, some possessing only a single huge polymorphic nucleus and others having two or more nuclei. (humpath.com)
  • Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant morphologic overlap with small cell carcinoma. (uchicago.edu)
  • Anaplasia did not affect outcome in patients with alveolar tumors. (elsevier.com)
  • Anaplasia may be identified in a subset of tumors with a presumed pilocytic astrocytoma (PA) component or piloid features, which may be associated with aggressive behavior, but the biologic basis of this change remains unclear. (northwestern.edu)
  • Lach B, Al-Shail E, Patay Z. Spontaneous anaplasia in cerebellar astrocytoma. (mcmaster.ca)
  • Anaplasia was more common in patients with tumors in favorable sites and was less commonly observed in younger patients and in those with stage II, III, or clinical group III disease. (elsevier.com)
  • Anaplasia is the most extreme disturbance in cell growth encountered in the spectrum of cellular proliferations. (wikipedia.org)
  • Chronic exposure to hypoxia (e.g., as occurs in individuals dwelling at high altitudes or in those with certain medical conditions, such as cyanotic heart and chronic lung diseases) induces cellular hyperplasia/anaplasia in the CB ( 4 ). (sciencemag.org)
  • PGL tumors display cellular hyperplasia/anaplasia ( 5 ) in the absence of any hypoxic stimulus. (sciencemag.org)
  • With focal anaplasia, there is one or a few very localized regions of anaplasia in the tumour. (cancer.ca)
  • The prevalence of anaplasia (focal or diffuse) was prospectively assessed in 546 eligible cases who were registered in an Intergroup Rhabdomyosarcoma Study Group (IRSG) or COG therapeutic trial from 1995 through 1998. (elsevier.com)
  • Regardless of its distribution (focal or diffuse), on univariate analysis the presence of anaplasia negatively influenced the failure-free survival rate (63% vs 77% at 5 years) and overall survival (68% vs 82% at 5 years) rates in patients with embryonal rhabdomyosarcoma. (elsevier.com)
  • The incidence of anaplasia in patients with rhabdomyosarcoma is higher than previously described and may be of prognostic significance in children with intermediate-risk embryonal rhabdomyosarcoma. (elsevier.com)
  • Anaplasia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • These findings further support the concept that PA with anaplasia is a neoplasm with heterogeneous genetic features and alterations typical of both PA and diffuse gliomas. (northwestern.edu)
  • Anaplasia may be focal or diffuse. (cancer.ca)
  • Anaplasia is a structural abnormality where cells resemble primitive or embryonic tissue in which adult functions are diminished or totally lost. (expertsmind.com)
  • We studied 40 patients with DAWT with anaplasia in the tissue from which DNA was extracted and analysed for TP53 mutations and 17p loss. (cdc.gov)
  • A recent review of cases from the Soft Tissue Sarcoma Committee of the Children's Oncology Group (COG) suggests that anaplasia might be more common than previously reported and may impact clinical outcome. (elsevier.com)
  • Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia. (uchicago.edu)
  • Whether pleomorphism-anaplasia warrants a worse prognosis has not been fully assessed so far. (wikipedia.org)
  • Chatten argued that increasing anaplasia in stage IV in comparison with stage III found in her cases suggested a trend toward higher stage (and worse prognosis) with anaplasia. (wikipedia.org)
  • Franklin E, Jenkins R (1973) Prospective studies of the association of genital herpes simplex infection and cervical anaplasia. (springer.com)
  • Anaplasia (ana-plasia) - the process of a cell reverting to an immature form. (thoughtco.com)
  • Prostatic intraepithelial neoplasia (PIN) is characterized by proliferation and anaplasia of cells lining ducts and acini. (biomedsearch.com)
  • ALT and ATRX loss, as well as alterations involving the MAPK pathway, are frequent in PA with anaplasia at the time of development of anaplasia or in their precursors. (northwestern.edu)
  • Five of these alterations were detected in large cell/anaplastic medulloblastomas or tumors with significant anaplasia. (nih.gov)
  • These have often gone further after malignancy has been attained, and have eventuated in great anaplasia. (rupress.org)
  • Anaplasia, which may be a feature of this subtype, adversely affects the likelihood of failure-free survival. (medscape.com)
  • These "high-grade" lesions make up approximately one quarter of medulloblastomas, and recur and metastasize more frequently than tumors lacking anaplasia. (nih.gov)
  • did not find any meaningful difference in clinical outcome between cases with or without anaplasia. (wikipedia.org)
  • However, within-stage differences were not significant, although cases without anaplasia fared better in each stage than those with. (wikipedia.org)
  • Tenascin in meningioma: Expression is correlated with anaplasia, with vascular endothelial growth factor expression and peritumoral edema. (edu.au)
  • Pleomorphism List of biological development disorders "anaplasia" - via The Free Dictionary. (wikipedia.org)
  • Expressions of pleomorphism-anaplasia have been fully acknowledged among the multifarious features of neuroblastoma in the classification by the International Neuroblastoma Pathology Committee. (wikipedia.org)
  • This graph shows the total number of publications written about "Anaplasia" by people in this website by year, and whether "Anaplasia" was a major or minor topic of these publications. (uchicago.edu)