Anacardic Acids
Anacardium
Salicylates
Chorioallantoic Membrane
Histone Acetyltransferases
Aminacrine
Corneal Neovascularization
New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.
Molecular Docking Simulation
Gelatinases
Zinc
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Nuts
Botanically, a type of single-seeded fruit in which the pericarp enclosing the seed is a hard woody shell. In common usage the term is used loosely for any hard, oil-rich kernel. Of those commonly eaten, only hazel, filbert, and chestnut are strictly nuts. Walnuts, pecans, almonds, and coconuts are really drupes. Brazil nuts, pistachios, macadamias, and cashews are really seeds with a hard shell derived from the testa rather than the pericarp.
p300-CBP Transcription Factors
A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.
Acetyltransferases
Myeloid Cells
Antigens, CD11b
Tumor Escape
The ability of tumors to evade destruction by the IMMUNE SYSTEM. Theories concerning possible mechanisms by which this takes place involve both cellular immunity (IMMUNITY, CELLULAR) and humoral immunity (ANTIBODY FORMATION), and also costimulatory pathways related to CD28 antigens (ANTIGENS, CD28) and CD80 antigens (ANTIGENS, CD80).
Ginkgolides
Ginkgo biloba
Electronic Mail
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Tsetse Flies
Digitoxigenin
Betalains
Phytochemicals
Glucosinolates
Anthraquinones
Betacyanins
Betaxanthins
Biological Products
Synthesis of anacardic acids, 6-[8(Z),11(Z)-pentadecadienyl]salicylic acid and 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid. (1/24)
11-Chloro-3-methoxy-2-undecenal was synthesized from 8-bromooctanol, and an annelation reaction with this aldehyde and ethyl acetoacetate proceeded to give the ethyl 6-(8-chlorooctyl)salicylate. Ethyl 6-(8-chlorooctyl)salicylate was converted to ethyl 6-(7-formylheptyl)-2-methoxybenzoate through the iodide after protection of the phenolic hydroxyl group. Finally, the Wittig reaction with the aldehyde and triphenylphosphonium iodides in the presence of BuLi gave the methoxybenzoates, and then treatments of these methoxybenzoates with BBr3 in CH2Cl2 and 10% NaOH in ethanol gave 6-18(Z),11(Z)-pentadecadienyllsalicylic acid (anacardic acid 3) and 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid (anacardic acid 4) which were isolated from plants of the anacardiaceae. (+info)Anacardic acid-mediated changes in membrane potential and pH gradient across liposomal membranes. (2/24)
We have previously shown that anacardic acid has an uncoupling effect on oxidative phosphorylation in rat liver mitochondria using succinate as a substrate (Life Sci. 66 (2000) 229-234). In the present study, for clarification of the physicochemical characteristics of anacardic acid, we used a cyanine dye (DiS-C3(5)) and 9-aminoacridine (9-AA) to determine changes of membrane potential (DeltaPsi) and pH difference (DeltapH), respectively, in a liposome suspension in response to the addition of anacardic acid to the suspension. The anacardic acid quenched DiS-C3(5) fluorescence at concentrations higher than 300 nM, with the degree of quenching being dependent on the log concentration of the acid. Furthermore, the K(+) diffusion potential generated by the addition of valinomycin to the suspension decreased for each increase in anacardic acid concentration used over 300 nM, but the sum of the anacardic acid- and valinomycin-mediated quenching was additively increasing. This indicates that the anacardic acid-mediated quenching was not due simply to increments in the K(+) permeability of the membrane. Addition of anacardic acid in the micromolar range to the liposomes with DeltaPsi formed by valinomycin-K(+) did not significantly alter 9-AA fluorescence, but unexpectedly dissipated DeltaPsi. The DeltaPsi preformed by valinomycin-K(+) decreased gradually following the addition of increasing concentrations of anacardic acid. The DeltaPsi dissipation rate was dependent on the pre-existing magnitude of DeltaPsi, and was correlated with the logarithmic concentration of anacardic acid. Furthermore, the initial rate of DeltapH dissipation increased with logarithmic increases in anacardic acid concentration. These results provide the evidence for a unique function of anacardic acid, dissimilar to carbonylcyanide p-trifluoromethoxyphenylhydrazone or valinomycin, in that anacardic acid behaves as both an electrogenic (negative) charge carrier driven by DeltaPsi, and a 'proton carrier' that dissipates the transmembrane proton gradient formed. (+info)Small molecule modulators of histone acetyltransferase p300. (3/24)
Histone acetyltransferases (HATs) are a group of enzymes that play a significant role in the regulation of gene expression. These enzymes covalently modify the N-terminal lysine residues of histones by the addition of acetyl groups from acetyl-CoA. Dysfunction of these enzymes is often associated with the manifestation of several diseases, predominantly cancer. Here we report that anacardic acid from cashew nut shell liquid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferase activities. Although it does not affect DNA transcription, HAT-dependent transcription from a chromatin template was strongly inhibited by anacardic acid. Furthermore, we describe the design and synthesis of an amide derivative N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide (CTPB) using anacardic acid as a synthon, which remarkably activates p300 HAT activity but not that of p300/CBP-associated factor. Although CTPB does not affect DNA transcription, it enhances the p300 HAT-dependent transcriptional activation from in vitro assembled chromatin template. However, it has no effect on histone deacetylase activity. These compounds would be useful as biological switching molecules for probing into the role of p300 in transcriptional studies and may also be useful as new chemical entities for the development of anticancer drugs. (+info)Characterization of xanthine oxidase inhibition by anacardic acids. (4/24)
Anacardic acid, 6[8(Z), 11(Z), 14-pentadecatrienyl]salicylic acid, inhibits generation of superoxide radicals by xanthine oxidase. This inhibition does not follow a hyperbolic inhibition, depends on anacardic acid concentrations, but follows a sigmoidal inhibition. The inhibition was analyzed by using a Hill equation, and slope factor and EC(50) were 4.3+/-0.5 and 53.6+/-5.1 microM, respectively. In addition, anacardic acid inhibited uric acid formation by xanthine oxidase cooperatively. Slope factor and EC(50) were 1.7+/-0.5 and 162+/-10 microM, respectively. The results indicate that anacardic acid binds to allosteric sites near the xanthine-binding domain in xanthine oxidase. Salicylic acid moiety and alkenyl side chain in anacardic acid are associated with the cooperative inhibition and hydrophobic binding, respectively. (+info)Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. (5/24)
Histone acetyltransferases (HATs) regulate transcription, chromatin structure and DNA repair. Here, we utilized a novel HAT inhibitor, anacardic acid, to examine the role of HATs in the DNA damage response. Anacardic acid inhibits the Tip60 HAT in vitro, and blocks the Tip60-dependent activation of the ATM and DNA-PKcs protein kinases by DNA damage in vivo. Further, anacardic acid sensitizes human tumor cells to the cytotoxic effects of ionizing radiation. These results demonstrate a central role for HATs such as Tip60 in regulating the DNA damage response. HAT inhibitors provide a novel therapeutic approach for increasing the sensitivity of tumors to radiation therapy. (+info)Characterization of novel inhibitors of histone acetyltransferases. (6/24)
Modification of proteins by histone acetyltransferases (HAT) or histone deacetylases plays an important role in the control of gene expression, and its dysregulation has been linked to malignant transformation and other diseases. Although histone deacetylase inhibitors have been extensively studied and several are currently in clinical trials, there is little information available on inhibitors of HATs (HATi). Starting from the natural product lead HATi anacardic acid, a series of 28 analogues was synthesized and investigated for HAT-inhibitory properties and effects on cancer cell growth. The compounds inhibited up to 95% HAT activity in vitro, and there was a clear correlation between their inhibitory potency and cytotoxicity toward a broad panel of cancer cells. Interestingly, all tested compounds were relatively nontoxic to nonmalignant human cell lines. Western blot analysis of MCF7 breast carcinoma cells treated with HATi showed significant reduction in acetylation levels of histone H4. To directly show effect of the new compounds on HAT activity in vivo, MCF7 cells were cotransfected with the p21 promoter fused to firefly luciferase and a full-length p300 acetyltransferase, and luciferase activity was determined following treatment with HATi. Significant inhibition of p300 activity was detected after treatment with all tested compounds except one. Effects of the new HATi on protein acetylation and HAT activity in vivo make them a suitable tool for discovery of molecular targets of HATs and, potentially, for development of new anticancer therapeutics. (+info)Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis. (7/24)
(+info)Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development. (8/24)
(+info)
Isomerization of anacardic acid - University of St Andrews
Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases | Cell & Bioscience | Full...
Plus it
Ginkgolic Acid 15:1 + 13:0(4:1) [Anacardic Acid 15:1 + 13:0] - Creative Proteomics
Anacardic Acid - Creative Enzymes
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Anacardic Acid
Phenolic lipid - Wikipedia
Epigenetic Regulation of Spinal CXCR2 Signaling in Incisional Hypersensitivity in Mice | Anesthesiology | ASA Publications
Epigenetic regulation of spinal CXCR2 signaling in incisional hypersensitivity in mice. | Sigma-Aldrich
L 002 | p300 HAT inhibitor | NSC 764414 | L002 | CAS [321695-57-2] | Axon 2319 | Axon Ligand™ with |99% purity available from...
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Cashews
Cashews
Cashew
Anacardic acid is also used in the chemical industry for the production of cardanol, which is used for resins, coatings, and ... The seed is surrounded by a double shell that contains an allergenic phenolic resin, anacardic acid-which is a potent skin ... Hamad F. B.; Mubofu E. B. (2015). "Potential biological applications of bio-based anacardic acids and their derivatives". Int J ... Cold, solvent-extracted CNSL is mostly composed of anacardic acids (70%), cardol (18%) and cardanol (5%). Heating CNSL ...
In natura
... subacute toxicity and mutagenic effects of anacardic acids from cashew (Anacardium occidentale Linn.) in mice". Journal of ...
Cashew
Cold, solvent-extracted CNSL is mostly composed of anacardic acids (70%),[40] cardol (18%) and cardanol (5%).[20][41] ... Anacardic acid is also used in the chemical industry for the production of cardanol, which is used for resins, coatings, and ... Heating CNSL decarboxylates the anacardic acids, producing a technical grade of CNSL that is rich in cardanol. Distillation of ... anacardic acid, and cardanol.[3][18] Due to the possible dermatitis, cashews are typically not sold in the shell to consumers.[ ...
List of phytochemicals in food
Anacardic acid cashews, mangoes. Malic acid apples. Caftaric acid grapes. Coutaric acid grapes. Fertaric acid Betaine beetroot ... Vanillin and Vanillic acid açaí oil, vanilla beans, cloves. Gallic acid tea, mango, strawberries, rhubarb, soy. Ellagic acid ... Chlorogenic acid echinacea, strawberries, pineapple, coffee, sunflower, blueberries. Cinnamic acid cinnamon, aloe. Ferulic acid ... Quinic acid Oxalic acid orange, spinach, rhubarb, tea and coffee, banana, ginger, almond, sweet potato, bell pepper. Tartaric ...
Cardanol
... is a phenolic lipid obtained from anacardic acid, the main component of cashew nutshell liquid (CNSL), a byproduct of ... is used for the decarboxylated derivatives obtained by thermal decomposition of any of the naturally occurring anacardic acids ...
Sanoor
... also has a cardanol-processing plant which extracts phenolic lipids from the anacardic-acid-rich cashew shells. The ...
Anacardium othonianum
The fruit's skin contains a strongly irritating oil composed mostly of anacardic acid, cardol, cardanol and other aromatic ... Its fatty fraction consists mostly of esters of the oleic (60%) and linoleic (21%) acids. The tea from its bark or leaves is ...
Phenolic lipid
Alkylcatechols Alkylphenols (nonylphenol, cardanol) Alkylresorcinols Anacardic acids Due to their strong amphiphilic character ...
پلیفنل - ویکیپدیا، دانشنامهٔ آزاد
Cashew nut shell liquid (CNSL) is an important phenolic raw material containing mostly cardol, cardanol and anacardic acid. ... The gallic acid dimer, ellagic acid (M.W. 302, right), a molecule at the core of naturally occurring phenolic compounds of ... The raspberry ellagitannin (M.W. ~2450),[9] on the other hand, with its 14 gallic acid moieties (most in ellagic acid-type ... Plant-derived polyphenol, tannic acid, formed by esterification of ten equivalents of the phenylpropanoid-derived gallic acid ...
C22H30O3
The molecular formula C22H30O3 (molar mass : 342.47 g/mol) may refer to: Anacardic acid, a chemical compound found in the shell ...
Anacardic acids
It was later found to be a mixture rather than one chemical, sometimes the plural anacardic acids is used. Anacardic acid is ... Anacardic acid (2-hydroxy-6-alkylbenzoic acid) provides resistance to small pest insects (aphids and spider mites). Anacardic ... Anacardic acids are phenolic lipids, chemical compounds found in the shell of the cashew nut (Anacardium occidentale). An acid ... Chemically, anacardic acid is a mixture of several closely related organic compounds. Each consists of a salicylic acid ...
Phytosteroid
Saturated cyclic acids *Phytic acid. *Quinic acid. *Oxalic acid. *Tartaric acid. *Anacardic acid ... Dihydroxybenzoic acids. *2,3-Dihydroxybenzoic acid (Hypogallic acid). *2,4-Dihydroxybenzoic acid ...
Naturally occurring phenols
Phenolic acids, Phenolic aldehydes Gallic, salicylic acids 8 C6-C2 1 Acetophenones, Tyrosine derivatives, Phenylacetic acids 3- ... Saturated cyclic acids *Phytic acid. *Quinic acid. *Oxalic acid. *Tartaric acid. *Anacardic acid ... Homogentisic acid 9 C6-C3 1 Hydroxycinnamic acids, Phenylpropenes, Coumarins, Isocoumarins, Chromones Caffeic, ferulic acids, ... Phenolic acids can be found in mushroom basidiomycetes species.[46] For example, protocatechuic acid and pyrocatechol are found ...
Ginkgo biloba
... bilobol is a substance related to anacardic acid from cashew nut shells and urushiols present in poison ivy and other ... It is attractive in appearance, but contains butyric acid[14] (also known as butanoic acid) and smells like rancid butter or ... Ginkgo biloba leaves and sarcotesta also contain ginkgolic acids,[61] which are highly allergenic, long-chain alkylphenols such ... Extracts of ginkgo leaves contain phenolic acids, proanthocyanidins, flavonoid glycosides, such as myricetin, kaempferol, ...
Dietary fiber
Saturated cyclic acids *Phytic acid. *Quinic acid. *Oxalic acid. *Tartaric acid. *Anacardic acid ... Short-chain fatty acids[edit]. When fermentable fiber is fermented, short-chain fatty acids (SCFA) are produced. SCFAs are ... Almost all of these short-chain fatty acids will be absorbed from the colon. This means that fecal short-chain fatty acid ... The production of short-chain fatty acids has several possible actions on the gut mucosa. All of the short-chain fatty acids ...
Dietary fiber
Saturated cyclic acids *Phytic acid. *Quinic acid. *Oxalic acid. *Tartaric acid. *Anacardic acid ... Short-chain fatty acids[edit]. When fermentable fiber is fermented, short-chain fatty acids (SCFA) are produced.[14] SCFAs are ... Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (2005), ... One action of some fibers is to reduce the reabsorption of bile acids in the ileum and hence the amount and type of bile acid ...
Anacardic acids - Wikipedia
It was later found to be a mixture rather than one chemical, sometimes the plural anacardic acids is used. Anacardic acid is ... Anacardic acid (2-hydroxy-6-alkylbenzoic acid) provides resistance to small pest insects (aphids and spider mites). Anacardic ... Anacardic acids are phenolic lipids, chemical compounds found in the shell of the cashew nut (Anacardium occidentale). An acid ... Chemically, anacardic acid is a mixture of several closely related organic compounds. Each consists of a salicylic acid ...
Lipoxygenase inhibitory activity of anacardic acids.
... otherwise known as anacardic acid (C15:1), inhibited the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC ... 0/Anacardic Acids; 0/Lipoxygenase Inhibitors; 18654-18-7/anacardic acid; 2197-37-7/Linoleic Acid; EC 1.13.11.12/Lipoxygenase ... 6[8(Z)-pentadecenyl]salicylic acid, otherwise known as anacardic acid (C15:1), inhibited the linoleic acid peroxidation ... otherwise known as anacardic acid (C15:2), was dioxygenated at low concentrations as a substrate. In addition, anacardic acid ( ...
Anacardic acid: the anti-oestrogen in cashew nuts | IronMag Bodybuilding Blog
Anacardic acid is a collective name for a number of compounds. The basic structure of anacardic acid is shown on the right ... Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid) is a dietary and medicinal phytochemical with established anticancer ... Anacardic acid: the anti-oestrogen in cashew nuts. Articles, Health, Science, Studies, Supplements ... Like anacardic acid, ginkgo inhibits the functioning of the estradiol receptor. [J Steroid Biochem Mol Biol. 2006 Aug;100(4-5): ...
Impregnation of Catheters with Anacardic Acid from Cashew nut Shell Prevents Staphylococcus aureus Biofilm Development. |...
Sustained release of anacardic acids was observed for 4 days. Anacardic acid-impregnated silicon catheters efficiently ... Anacardic acids are antibacterial phenolic lipids from cashew nut (Anacardium occidentale) shell oil. Anacardic acid- ... AIM: The effect of anacardic acid impregnation on catheter surfaces for the prevention of Staphylococcus aureus attachments and ... The in vivo antibiofilm activity of anacardic acid-impregnated catheters was tested in an intraperitoneal catheter-associated ...
Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal...
Anacardic acid, the primary active component of cashew nut shell extract, is a natural product used in the treatment of a ... We find that anacardic acid stimulates the production of reactive oxygen species and neutrophil extracellular traps, two ... Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal ... Bipin G. Nair, J Perry, J. P., and Nizet, V., "Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil ...
Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 | Molecular...
Our docking studies suggested that anacardic acid binds into the MMP-2/9 active site, with the carboxylate group of anacardic ... Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9. Athira Omanakuttan ... Inhibition of Gelatinases by Anacardic Acid. Athira Omanakuttan, Jyotsna Nambiar, Rodney M. Harris, Chinchu Bose, Nanjan ... Inhibition of Gelatinases by Anacardic Acid. Athira Omanakuttan, Jyotsna Nambiar, Rodney M. Harris, Chinchu Bose, Nanjan ...
Anacardic Acid
See also Urushiol.) Anacardic acid is a mixture of 2-hydroxy-6-alkylbenzoic acids in which the alkyl chain (C11 or higher) is ... Title: Anacardic Acid. Literature References: Principal constituent of cashew nut-shell liquid, Anacardium occidentalis L., ... The name anacardic acid is also used in the literature to designate one component of the mixture: 6-pentadecyl-2-hydroxybenzoic ... acid (I) (6-pentadecylsalicylic acid). Another component of the mixture 6-(8-pentadecenyl)-2-hydroxybenzoic acid (II), is also ...
Anacardic Acid - Creative Enzymes
Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A - ATM - p53 signaling...
Anacardic acid induced an anticancer effect in pancreatic cancer cell lines in a dose dependent manner, and increased the ... Mechanistically, Anacardic acid exerted its anticancer activity via the activation of Chmp1A, ATM, and p53. Interestingly, 5- ... The aim of this study was to assess the potential therapeutic effect of Anacardic acid on pancreatic cancer in vitro and ... In addition, Chmp1A was silenced with shRNA to examine the necessity of Chmp1A for the anticancer effect of Anacardic acid, 5- ...
Anacardic Acid - CAS 16611-84-0 - Calbiochem CAS 16611-84-0 | 172050
Calbiochem Anacardic Acid, CAS 16611-84-0, is a cell-permeable ginkgolic acid analog that targets SUMO-activating enzyme E1 and ... More,, Anacardic Acid, CAS 16611-84-0, is a cell-permeable ginkgolic acid analog that targets SUMO-activating enzyme E1 and ... Anacardic Acid, CAS 16611-84-0, is a cell-permeable ginkgolic acid analog that targets SUMO-activating enzyme E1 and inhibits ... Anacardic Acid, CAS 16611-84-0, is a cell-permeable ginkgolic acid analog that targets SUMO-activating enzyme E1 and inhibits ...
Anacardic acid -. Ayurvedic medicine, old industrial phytochemical with newly discovered molecular actions and health...
Basics about anacardic acid. The medicinal use of anacardic acid goes back long before it was called that. "The traditional ... Anacardic acid is mainly found in the shell.. Anacardic acid is a collective name. Chemists have identified dozens of molecular ... Anacardic acid is effective against MRSA bacteria. Probably the most interesting application of anacardic acid is that it is ... Anacardic acid may help protect lungs from air pollutants. The 2013 publication Anacardic Acids from Cashew Nuts Ameliorate ...
Eliminate Toothache Infection (Abscess) With Anacardic Antibiotic in Cashew Nuts
It is proposed that anacardic acids in raw cashew nuts will cure gram positive tooth abscess or infection, and maybe leprosy, ... 12....Eichbaum FW 1946 Biological properties of anacardic acid (O- pentadeca dienylsalicylic acid) and related compounds. ... I have no absolute certainty that the nuts contain anacardic acids as do the pears. However, it is very unlikely that the plant ... You may see an extensive review of anacardic acids in this site. Not all tooth infections are gram positive bacteria, so ...
Anacardic acid, 10mg - UCB-Bioproducts Neurbiologicals
Anacardic acid, 10mg To Order Contact us: [email protected] Anacardic Acid. ... activity in prostate cancer with an IC50 value of about 5.0 M.Anacardic acid (AA) is commonly regarded as a non-specific HAT ... activity in prostate cancer with an IC50 value of about 5.0 M.Anacardic acid (AA) is commonly regarded as a non-specific HAT ... activity in prostate cancer with an IC50 value of about 5.0 M.Anacardic acid (AA) is commonly regarded as a non-specific HAT ...
Anacardic Acid
Ginkgolic Acid 15:1 + 13:0(4:1) [Anacardic Acid 15:1 + 13:0] - Creative Proteomics
Isomerization of anacardic acid - University of St Andrews
Anacardic acid, Benzolactone, Double bond isomerisation, Isoanacardic acid, Kairomone, Nut-shell liquid, Fatty-acids, Cashew, ... Isomerization of monoene anacardic acid resulted in a crystalline isoanacardic acid, (E)-2-hydroxy-6-(pentadec-1-enyl)benzoic ... Isomerization of anacardic acid: a possible route to the synthesis of an unsaturated benzolactone and a kairomone. Research ... Benzolactones derived from anacardic acid reported in this work have some structural similarity with lactones such as massoia ...
Anacardic acid induces cell apoptosis associated with induction of ATF4-dependent endoplasmic reticulum stress | Read by QxMD
Anacardic acid (6-pentadecylsalicylic acid, AA), a natural compound isolated from the traditional medicine Amphipterygium ... Anacardic acid induces cell apoptosis associated with induction of ATF4-dependent endoplasmic reticulum stress. Hongbiao Huang ... Induction of the endoplasmic reticulum stress and autophagy in human lung carcinoma A549 cells by anacardic acid. Yeong-Ae ... Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP ...
SYNTHESIS AND ANTI-MYCOBACTERIAL ACTIVITY OF SOME NOVEL ANACARDIC ACID DERIVATIVES FROM CASHEW NUT SHELL LIQUID | INTERNATIONAL...
Home » SYNTHESIS AND ANTI-MYCOBACTERIAL ACTIVITY OF SOME NOVEL ANACARDIC ACID DERIVATIVES FROM CASHEW NUT SHELL LIQUID ... SYNTHESIS AND ANTI-MYCOBACTERIAL ACTIVITY OF SOME NOVEL ANACARDIC ACID DERIVATIVES FROM CASHEW NUT SHELL LIQUID. Abstract ... Synthesis and anti-mycobacterial activity of some novel derivatives of anacardic acid viz., 2-Ethoxy-6-pentadecyl benzamide ( ... Anti-mycobacterial activity was performed using Mycobaterium smegmatis mc2 155, taking anacardic acid and ethambutol as ...
Anacardic acid attenuates pressure‐overload cardiac hypertrophy through inhibiting histone acetylases - Semantic Scholar
A Chinese herbal extract containing anacardic acid (AA) is known to possess strong histone acetylation inhibitory effects. In ... Phenylephrine-induced cardiac hypertrophy is attenuated by a histone acetylase inhibitor anacardic acid in mice.. Chang Peng, ... A Chinese herbal extract containing anacardic acid (AA) is known to possess strong histone acetylation inhibitory effects. In… ... Anacardic acid attenuates pressure‐overload cardiac hypertrophy through inhibiting histone acetylases. @inproceedings{ ...
Phytochemicals | MindMeister Mind Map
Histone Acetyltransferase | Histone Acetyltransferase Activity
Anacardic Acid. Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor ... Anacardic Acid. Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor ... Ginkgolic Acid. Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent ... Ginkgolic Acid. Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent ...
Ginkgolic Acid 17:1 + 15:0(6:1) [Anacardic Acid 17:1 + 15:0] - Creative Proteomics
Scientists look at anacardic acid as a potential treatment for pancreatic cancer - Dr. Eddy Bettermann MD
They reported that anacardic acid from cashew nuts could help mitigate the growth and spread of pancreatic cancer. A highly ... anacardic acid only, anacardic acid combined with the anticancer drug 5-Fluorouracil, or anacardic acid and another anticancer ... Tagged anacardic acid, anticancer, Cancer, cashews, cytotoxic, dietary supplements, goodhealth, Nutrition, pancreatic cancer, ... Scientists look at anacardic acid as a potential treatment for pancreatic cancer. ...
Ginkgo Biloba - Healthy.net
fatty acids and in particular, arachidonic acid. This last compound is. responsible for the production of membrane "aggressors ... Krebs-Ringer medium with 0.1 mM ascorbic acid. Ascorbic acid was responsible. for this decrease. Its effectiveness after a 60 ... Ginkgo biloba extract EGb 761 or trolox C prevent the ascorbi acid/Fe2+. induced decrease in synaptosomal membrane fluidity. ... UV-C irradiation-induced peroxidative degradation of microsomal fatty acids. and proteins: protection by an extract of Ginkgo ...
SUMOYlation Inhibitors
Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases | Cell & Bioscience | Full...
We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen ... Ginkgolic acid and anacardic acid are dual inhibitors targeting both PLpro and 3CLpro of SARS-CoV-2. To validate ginkgolic acid ... Ginkgolic acid and anacardic acid exhibit antiviral activity in vitro. To evaluate the antiviral potency of ginkgolic acid and ... Given the high structural similarity of ginkgolic acid and anacardic acid, we focused on ginkgolic acid to further elucidate ...
Search Results | jns
The present study evaluates the effect of anacardic acid (6-pentadecyl salicylic acid), a natural histone acetyltransferase ... Anacardic acid also reduced the expression of survivin and X-linked inhibitor of apoptosis protein, antiapoptotic proteins ... Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells Laboratory investigation ... These findings warrant further exploration of anacardic acid as a single agent or as an adjunct to radiation therapy for the ...
Animals | Free Full-Text | Can Agro-Industrial By-Products Rich in Polyphenols be Advantageously Used in the Feeding and...
Effects on milk production, milk and rumen liquor fatty acid profile, metabolic parameters, and methane production are reviewed ... Gallotannins, flavonoids, anacardic acids.. [40,64,65]. Pomegranate. Pomegranate seeds. 27.2. 16.9. 0.8. -. Flavonoids, ... Hydroxytyrosol, tyrosol oleuropein, gallic acid, ferulic acid, coumaric acids, p-hydroxybenzoic acid, flavonoids. [51,52,53,54] ... Hydroxitirosol, oleuropein, tyrosol, syringing acid, caffeic acid, vanillic acid, verbacoside, catechol, rutin. [60,61,62]. ...
The anti-inflammatory effects of anacardic acid on a tnf-α-induced human saphenous vein endothelial cell culture model | AVESİS
Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor...
6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation ... Abstract: Anacardic acid (AA) is a mixture of 2-hydroxy-6-alkylbenzoic acid homologs. It is widely regarded as a non-specific ... Cite this article as: Tan J, Chen B, He L, Tang Y, Jiang Z, Yin G, Wang J, Jiang X. Anacardic acid (6-pentadecylsalicylic acid ... Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor ...
LipidsSalicylicInhibitsGinkgolic acidCardanolDerivativesEffect of anacardic acidShows that anacardic acidProperties of anacardic acidCorrelation between anacardic acidContains anacardic acidP300CompoundsEffects of anacardicInducesSuggest that anacardicMethicillin resistCashewsCashew appleLinoleic AcidComponent of cashewCardolInhibitNucleic AciAnacardiumPancreatic cancer cellsGallic acidHistone acetylationInhibitoryMolecularFattySynergisticAlkylAnticancer effectAntibacterialNutsMangoBactericidalSubstanceStimulatesGemcitabineChemistryActivityUrushiolAcetic-acidCharacterizationKineticsProteinDietaryEffectivelyAntioxidantsBacteriaChmp1A
Lipids4
- Anacardic acids are phenolic lipids, chemical compounds found in the shell of the cashew nut (Anacardium occidentale). (wikipedia.org)
- Anacardic acids are antibacterial phenolic lipids from cashew nut (Anacardium occidentale) shell oil. (amrita.edu)
- The shells contain a motley of compounds called phenolic lipids, cardanol, and anacardic acid. (thedailybeast.com)
- The shell of the cashew nut contains oil compounds which may cause contact dermatitis similar in severity to that of poison ivy, primarily resulting from the phenolic lipids, anacardic acid and cardanol. (exportersindia.com)
Salicylic7
- Each consists of a salicylic acid substituted with an alkyl chain that has 15 or 17 carbon atoms. (wikipedia.org)
- 6-pentadecyl salicylic acid (6-PDSA), a potent HAT inhibitor from cashew nut shell liquid, and sensitizer of cancer cells to ionizing radiation. (wikipedia.org)
- 6[8'(Z)-pentadecenyl]salicylic acid, otherwise known as anacardic acid (C15:1), inhibited the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, type 1) with an IC50 of 6.8 microM. (biomedsearch.com)
- Although anacardic acid (C15:1) inhibited the linoleic acid peroxidation without being oxidized, 6[8'(Z),11'(Z)-pentadecadienyl]salicylic acid, otherwise known as anacardic acid (C15:2), was dioxygenated at low concentrations as a substrate. (biomedsearch.com)
- Literature frequently sites and gives the name anacardic acid to the completely-saturated compound (6-pentadecyl salicylic acid). (anti-agingfirewalls.com)
- In Arabidopsis , much of what we know about the phytohormone salicylic acid (SA) and its role in plant defense comes from experiments using young plants. (frontiersin.org)
- The phenolic phytohormone salicylic acid (SA) contributes to a number of developmental and physiological responses in plants. (frontiersin.org)
Inhibits4
- Like anacardic acid, ginkgo inhibits the functioning of the estradiol receptor. (ironmagazine.com)
- Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation. (ironmagazine.com)
- Anacardic Acid, CAS 16611-84-0, is a cell-permeable ginkgolic acid analog that targets SUMO-activating enzyme E1 and inhibits protein SUMO modification (IC50 = 2.2 µM) in an ATP-dependent manner. (merckmillipore.com)
- Oatmeal is typically eaten as an unsoaked whole grain (and soaking it isn't very effective in any case), and so it is high in phytic acid, which effectively inhibits the absorption of a number of minerals including calcium. (blogspot.com)
Ginkgolic acid5
- A cell-permeable ginkgolic acid (Cat. (merckmillipore.com)
- Both anacardic acid and ginkgolic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although anacardic acid is shown to inhibit p300 (Cat. (merckmillipore.com)
- Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT) . (selleckchem.com)
- We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2 papain-like protease (PL pro ). (biomedcentral.com)
- A library consisting of 1920 natural products was subsequently screened and two compounds ginkgolic acid and anacardic acid were identified to have antiviral potency against SARS-CoV-2. (biomedcentral.com)
Cardanol3
- Anacardic acid is the main component of cashew nutshell liquid (CNSL), and finds use in the chemical industry for the production of cardanol, which is used for resins, coatings, and frictional materials. (wikipedia.org)
- However, the hydrophobic interaction alone is not enough because cardanol (C15:1), which possesses the same side chain as anacardic acid (C15:1), acted neither as a substrate nor as an inhibitor. (biomedsearch.com)
- The major (90 %) component of CNSL is anacardic acid, which is easily decarboxylated to cardanol (10 %) by use of conventional methods. (springer.com)
Derivatives4
- The hydroalcoholic extract of this propolis, rich in flavone-6,8-di- C -glycosides (vicenin-2 and schaftoside), pyrrolizidine alkaloids derived from retronecine, catechin and caffeoylquinic acid derivatives exhibited antiviral activity against the herpes simplex and rubella viruses. (scielo.br)
- Bill Weigel from UC Riverside with his prize-winning organic poster on anacardic acid derivatives for enzyme-inhibition studies. (rsc.org)
- Hon, Y.-S., Liu, Y.-W. and Hsieh, C.-H. (2004) Dibromomethane as One-Carbon Source in Organic Synthesis A Versatile Methodology to Prepare the Cyclic and Acyclic Methylene or α-Keto Acid Derivatives from the Corresponding Terminal Alkenes. (scirp.org)
- In addition to anacardic acid and its derivatives (56, 57), several types of natural chemicals have been reported to bind HATs, such as epigallocatechin-3-gallate (58), plumbagin (59), curcumin (60), and garcinol (61). (nih.gov)
Effect of anacardic acid3
- AIM: The effect of anacardic acid impregnation on catheter surfaces for the prevention of Staphylococcus aureus attachments and biofilm formations were evaluated. (amrita.edu)
- The aim of this study was to assess the potential therapeutic effect of Anacardic acid on pancreatic cancer in vitro and elucidate its underlying mechanisms. (biomedcentral.com)
- In addition, Chmp1A was silenced with shRNA to examine the necessity of Chmp1A for the anticancer effect of Anacardic acid, 5-Fluorouracil, or Gemcitabine. (biomedcentral.com)
Shows that anacardic acid1
- The figure below shows that anacardic acid boosted the number of mono- and oligonucleosomes in the estradiol sensitive cells. (ironmagazine.com)
Properties of anacardic acid2
- Eichbaum FW 1946 Biological properties of anacardic acid (O- pentadeca dienylsalicylic acid) and related compounds. (wikipedia.org)
- If you wish to learn more about the anti-cancer properties of anacardic acid, visit CancerSolutions.news . (dreddymd.com)
Correlation between anacardic acid2
- They found a correlation between anacardic acid and the good gut bacteria. (ajmc.com)
- We examined metabolites in these subjects and found the strongest correlation between anacardic acid, present in cashews and mangoes, and the beneficial bacteria," Dr. Koh said. (eurekalert.org)
Contains anacardic acid1
- Mango fruit also contains anacardic acid. (tripod.com)
P3004
- Description: IC50: Noncompetitively inhibit histone acetyltransferase (HAT) activity in prostate cancer with an IC50 value of about 5.0 M.Anacardic acid (AA) is commonly regarded as a non-specific HAT inhibitor of p300. (ucb-bioproducts.com)
- Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases , which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition. (selleckchem.com)
- Results from a recent study, in which molecular docking simulation was used, suggest that anacardic acid competes with acetyl-CoA for the VKG site in p300/cAMP-response element-binding protein-associated factor (54). (nih.gov)
- Anacardic acid is an alkylsalicylic acid obtained from cashew-nut-shell liquid, and is a potent inhibitor of p300 histone acetyl-transferase (HAT) activity. (ucl.ac.uk)
Compounds8
- Chemically, anacardic acid is a mixture of several closely related organic compounds. (wikipedia.org)
- Anacardic acid is a collective name for a number of compounds. (ironmagazine.com)
- Later, the substance was found to consist of a family of related acid compounds( ref ). (anti-agingfirewalls.com)
- Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-alkyl salicyclic acids having varying degrees of unsaturation in the 15-carbon alkyl chain.1 These compounds are associated with anti-inflammatory, anti-tumor, molluscicidal, and anti-microbial activity. (anti-agingfirewalls.com)
- 2-Ethoxy-6-pentadecyl benzamide (APHK-1), 1-(2-methoxy-6-pentadecylbenzyl)-4-hydroxy ethylpiperazine (APHK-2), 1- (2-hydroxy-6-pentadecyl)- N- (hydroxyl ethylaminoethyl) benzamide (APHK-3) and compounds 20-34 from saturated anacardic acid which was obtained from natural product cashew nut shell liquid (CNSL) is reported. (ijpsr.com)
- The nut shells, in fact, are toxic and dangerous, soaked in oil compounds that can effectively burn your skin just as badly as dangerous acids. (thedailybeast.com)
- Anacardic compounds in cashew nuts and maybe mangoes do an excellent job of curing an abscess from gram positive bacteria, which are the most prevalent cause of tooth decay and tooth aches. (scienceblog.com)
- Six oxylipins strongly inhibited mycelial growth and spore germination of eukaryotic microbes, including compounds that had not previously been ascribed an antimicrobial activity, such as 13-keto-9( Z ),11( E ),15( Z )-octadecatrienoic acid and 12-oxo-10,15( Z )-phytodienoic acid. (plantphysiol.org)
Effects of anacardic1
- Synergistic effects of anacardic acids and methicillin against methicillin-resistant Staphylococcus aureus. (berkeley.edu)
Induces1
- Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen. (amegroups.com)
Suggest that anacardic1
- CONCLUSIONS: Our data suggest that anacardic acid-impregnated silicon catheters may help in preventing catheter-related staphylococcal infections. (amrita.edu)
Methicillin resist1
- Anacardic acid kills methicillin-resistant Staphylococcus aureus (MRSA) cells more rapidly than totarol. (wikipedia.org)
Cashews4
- This type of acid is present in mangoes and cashews, and the researchers were interested to note that 5 of the 6 patients with the highest anacardic acid levels consumed cashews at least once a week. (ajmc.com)
- Cashews contain more starch and omega-3 fatty acids than tree nuts such as almonds," says Barry Sears, M.D., author of The Mediterranean Zone . (pastemagazine.com)
- For instance, there are a few published animal studies on anacardic acid-a compound in cashews. (eatingwell.com)
- That is not particularly exciting news, but it should settle the minds of gout sufferers who worry about the uric acid content of cashews. (goutpal.com)
Cashew apple2
- Products containing cashew apple juice probably contain considerably more of the stuff, going by the concentrations of anacardic acid that chemists have found in the cashew apple. (ironmagazine.com)
- Anacardic acid is a dietary supplement derived from cashew apple and nut, cashew nutshell liquid, and mangoes. (dreddymd.com)
Linoleic Acid2
- Walnut oil is a drying oil (heavy in linoleic and linoleic acid esters). (madsci.org)
- They originate from oxidation and further conversions of polyunsaturated fatty acids (PUFAs), predominantly linoleic acid (18:2) and linolenic acid (18:3). (plantphysiol.org)
Component of cashew2
- Anacardic acid, the primary active component of cashew nut shell extract, is a natural product used in the treatment of a variety of medical conditions, including infectious abscesses. (amrita.edu)
- The fact that 3-propylphenol can be synthesized from anacardic acid, a component of cashew nut shell liquid is of particular interest since most of the areas affected with tsetse flies are suitable for growing cashew plants. (st-andrews.ac.uk)
Cardol2
- Cashew nut shell liquid (oil of cashew nut shell, Anacardium occidentale) contains cardol (irritant) and anacardic acids. (madsci.org)
- The poisonous black juice contained between the outer and inner shell contains two peculiar principles, Anacardic acid and Cardol. (homeoint.org)
Inhibit2
- Anacardic acid is known to inhibit an enzyme involved in gene expression called histone acetyltransferase, or HAT. (ptproductsonline.com)
- Suberoylanilide hydroxamic acid and anacardic acid were used to inhibit histone deacetylase and histone acetyltransferase, respectively. (sigmaaldrich.com)
Nucleic Aci1
- Nucleic Acids Res 46:1565-1583 (2018). (abcam.com)
Anacardium1
- 2018) Anxiolytic effect of anacardic acids from cashew (Anacardium occidentale) nut shell in mice. (panlab.com)
Pancreatic cancer cells3
- Human pancreatic cancer cells were treated with Anacardic acid and assessed for the cytotoxic effect using MTT and spheroid formation assays. (biomedcentral.com)
- Last but not least, they separately tested anacardic acid, 5-Fluorouracil, and Gemcitabine on human pancreatic cancer cells that have silenced Chmp1A molecules. (dreddymd.com)
- The UPike researchers reported that pure anacardic acid was able to suppress the growth of pancreatic cancer cells. (dreddymd.com)
Gallic acid3
- Plant-derived polyphenol, tannic acid, formed by esterification of ten equivalents of the phenylpropanoid -derived gallic acid to a monosaccharide (glucose) core from primary metabolism. (wikipedia.org)
- Raspberry ellagitannin , a tannin composed of 14 gallic acid units around a core of three units of glucose, with two gallic acids as simple esters, and the remaining 12 appearing in 6 ellagic acid-type units. (wikipedia.org)
- Mangoes also contain several important phytochemicals including: Cryptoxanthin, Lutein, Gallic Acid and Anacardic acid. (bewellbuzz.com)
Histone acetylation2
- A Chinese herbal extract containing anacardic acid (AA) is known to possess strong histone acetylation inhibitory effects. (semanticscholar.org)
- In addition, inhibition of histone acetylation by anacardic acid reduces the UV-B induced, UVR8 mediated expression of ELIP1 and CHS. (deepdyve.com)
Inhibitory2
- Lipoxygenase inhibitory activity of anacardic acids. (biomedsearch.com)
- The alk(en)yl side chain of anacardic acids is essential to elicit the inhibitory activity. (biomedsearch.com)
Molecular6
- A handful of cashew nuts contains about 20 mg anacardic acid, a substance that has an anti-oestrogenic effect, molecular biologists at the University of Louisville discovered. (ironmagazine.com)
- Molecular researchers have been performing experiments with anacardic acid for a few years and have reported encouraging results. (ironmagazine.com)
- Molecular modeling and pharmacological inhibitor studies suggest anacardic acid stimulation of neutrophils occurs in a PI3K-dependent manner through activation of surface-expressed G protein-coupled sphingosine-1-phosphate receptors. (amrita.edu)
- To elucidate the underlying molecular mechanisms, Western blot analysis and immunocytochemistry were performed on cancer cells treated with Anacardic acid alone or in combination with 5-Fluorouracil or Gemcitabine. (biomedcentral.com)
- Life sciences research interest in anacardic acid it has been accelerating with the rise in knowledge about molecular biology and epigenetics. (anti-agingfirewalls.com)
- Furthermore, they studied the molecular mechanisms involved in the anticancer activity of anacardic acid. (dreddymd.com)
Fatty9
- Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. (qxmd.com)
- Effects on milk production, milk and rumen liquor fatty acid profile, metabolic parameters, and methane production are reviewed. (mdpi.com)
- This plant-based drink is rich in polyunsaturated and monounsaturated fatty acids . (healthline.com)
- The roasted nuts are usually prepared with additional omega-6 fatty acids and salt, and roasting can damage some of the polyphenols in nuts," says Dr. Sears. (pastemagazine.com)
- Plant oxylipins are a large family of metabolites derived from polyunsaturated fatty acids. (plantphysiol.org)
- Other oxylipins, such as epoxy and dihydroxy fatty acids, can be formed from C18 PUFAs by the peroxygenase/epoxide hydrolase pathway ( Blée, 1998 ). (plantphysiol.org)
- Additionally, they compose proper amounts of monounsaturated fatty acids like oleic acid and antioxidants. (nutrition-and-you.com)
- Research studies suggest that the Mediterranean diet which is rich in dietary fiber, monounsaturated fatty acids, and antioxidants can help reduce coronary artery disease and stroke risk by favoring healthy blood lipid profile. (nutrition-and-you.com)
- Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. (abcam.com)
Synergistic2
- Anacardic acid is synergistic with anethole from the seed of anise (Umbelliferae) and linalool from green tea in vitro [Muroi & Kubo, p1782]. (wikipedia.org)
- The totarol in the bark of Podocarpus trees is synergistic with anacardic acid in its bactericidal effects. (wikipedia.org)
Alkyl2
- Anacardic acid is a mixture of 2-hydroxy-6-alkylbenzoic acids in which the alkyl chain (C 11 or higher) is fully saturated (I) or is a monoene (II), a diene (III) or a triene (IV). (drugfuture.com)
- Crystalline unsaturated lactone, 8-hydroxy-3-tridecyl-1H-isochromen-1-one ( 6 ) has been synthesized by isomerization of anacardic acid having heterogeneous alkyl side chains (a mixture of mono-, di-, and tri-unsaturated anacardic acid) ( 1 ). (st-andrews.ac.uk)
Anticancer effect2
- Anacardic acid induced an anticancer effect in pancreatic cancer cell lines in a dose dependent manner, and increased the cytotoxicity of 5-Fluorouracil or Gemcitabine in MTT cell viability assays. (biomedcentral.com)
- This suggested that anacardic acid relies on Chmp1A for its anticancer effect. (dreddymd.com)
Antibacterial1
- Once-unknown mechanisms underlying its antibacterial, anti-tumor, anti-inflammatory and other interesting properties are increasingly better understood, and the acid is of increasing interest for its practical anti-cancer and other health-inducing properties. (anti-agingfirewalls.com)
Nuts11
- Chemists have identified dozens of variants of anacardic acid in cashew nuts, which happen to be the best nutritional source of anacardic acid. (ironmagazine.com)
- I have no absolute certainty that the nuts contain anacardic acids as do the pears. (tripod.com)
- Modern history of the substance goes back to a publication in 1847 which described an acid found in the shells of cashew nuts named anacardic acid. (anti-agingfirewalls.com)
- Anacardic acids occurs naturally in cashew nuts (the most accessible natural dietary source), mangos, and cashew apples. (anti-agingfirewalls.com)
- They reported that anacardic acid from cashew nuts could help mitigate the growth and spread of pancreatic cancer. (dreddymd.com)
- Anacardic acids in cashew nuts have promising neuroprotective action against degenerative changes in Parkinson's disease. (greenmedinfo.com)
- I have found that the anacardic acids in raw cashew nuts and maybe mangoes do an excellent job of curing an abscess from gram positive bacteria, which are the most prevalent cause of tooth decay and tooth aches. (scienceblog.com)
- Anacardic acid isn't in the nut that we eat, though some may remain depending on how the nuts were processed. (eatingwell.com)
- The nuts are packed with many important B-complex groups of vitamins such as riboflavin, niacin, thiamin, pantothenic acid, vitamin B-6, and folates. (nutrition-and-you.com)
- The first important fact about cashew nuts and gout is that they have no effect on uric acid. (goutpal.com)
- In Effects of a high walnut and high cashew nut diet on selected markers of the metabolic syndrome: a controlled feeding trial the researchers make it quite clear that neither walnuts nor unsalted cashew nuts had any effect on uric acid in the blood. (goutpal.com)
Mango2
- It is conceivable that mango fruits may have sufficient anacardic acids as well. (scienceblog.com)
- It is caused due to anacardic acid found in mango flesh and rind. (hubpages.com)
Bactericidal2
- Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. (amrita.edu)
- Neutrophil extracellular traps produced in response to anacardic acid are bactericidal and complement select direct antimicrobial activities of the compound. (amrita.edu)
Substance3
- Did we just say that anacardic acid is a substance? (ironmagazine.com)
- In addition to analyzing the cytotoxic effects of pure anacardic acid, the researchers also sought to determine any synergy between the natural substance and the two synthetic anticancer drugs. (dreddymd.com)
- The key active compound in this mix is anacardic acid, and it's this substance that is most intriguing for scientists. (thedailybeast.com)
Stimulates1
- We find that anacardic acid stimulates the production of reactive oxygen species and neutrophil extracellular traps, two mechanisms utilized by neutrophils to kill invading bacteria. (amrita.edu)
Gemcitabine4
- Using the same methods, the synergy between Anacardic acid and 5-Fluorouracil or Gemcitabine was determined. (biomedcentral.com)
- Silencing experiments indicate that Chmp1A is required for the action of Anacardic acid, but not for 5-Fluorouracil or Gemcitabine. (biomedcentral.com)
- They subjected these cancer cell cultures to three different treatments: anacardic acid only, anacardic acid combined with the anticancer drug 5-Fluorouracil, or anacardic acid and another anticancer drug, Gemcitabine. (dreddymd.com)
- Furthermore, when combined with 5-Fluorouracil or Gemcitabine, anacardic acid was able to improve the cytotoxic effects of either anticancer drug. (dreddymd.com)
Chemistry1
- Polyaniline (PAni) in the emeraldine salt form is one of the most widely studied conducting polymers because of its easy synthesis, low cost, and acid-doping/dedoping chemistry-based property. (scielo.br)
Activity11
- Heating these anacardic acids converts them to the alcohols (cardanols) with reduced activity compared to the acids. (wikipedia.org)
- The inhibition of the enzyme by anacardic acid (C15:1) is a slow and reversible reaction without residual activity. (biomedsearch.com)
- 2-hydroxy-6-alkylbenzoic acid) is a dietary and medicinal phytochemical with established anticancer activity in cell and animal models. (ironmagazine.com)
- Anacardic acid-impregnated silicon catheters revealed no significant haemolytic activity and were cytocompatible against fibroblast cell line (L929). (amrita.edu)
- The in vivo antibiofilm activity of anacardic acid-impregnated catheters was tested in an intraperitoneal catheter-associated medaka fish infection model. (amrita.edu)
- Mechanistically, Anacardic acid exerted its anticancer activity via the activation of Chmp1A, ATM, and p53. (biomedcentral.com)
- Anti-mycobacterial activity was performed using Mycobaterium smegmatis mc 2 155, taking anacardic acid and ethambutol as standards. (ijpsr.com)
- Anacardic acid achieved this cancer-suppressing activity by activating Chmp1A, ATM, and p53. (dreddymd.com)
- In this study, we investigated whether caffeic acid regulates Rac1 GTPase activity, a partner of NADPH oxidase. (biomedsearch.com)
- Activity of the plant mitochondrial alternative oxidase (AOX) can be regulated by organic acids, notably pyruvate. (biomedsearch.com)
- Following addition of 1 mg of recombinant PB2 cap-binding domain proteins, incubation was performed for 30 min at 30 °C. Anacardic acid and garcinol showed strong inhibition of the binding activity of recombinant PB2 with [14C]acetyl-CoA. (nih.gov)
Urushiol1
- An acid form of urushiol, they also cause an allergic skin rash on contact, known as urushiol-induced contact dermatitis. (wikipedia.org)
Acetic-acid1
- Guaragnella N, Bobba A, Passarella S (2010) Yeast acetic acid induced programmed cell death can occur without cytochrome c release which requires metacaspase YCA1. (springer.com)
Characterization1
- Characterization of xanthine oxidase inhibition by anacardic acids. (berkeley.edu)
Kinetics1
- The inhibition kinetics analyzed by Dixon plots indicates that anacardic acid (C15:1) is a competitive inhibitor and the inhibition constant, KI, was obtained as 2.8 microM. (biomedsearch.com)
Protein2
- The researchers discovered that anacardic acid didn't force estradiol out of its socket in the receptor protein. (ironmagazine.com)
- By increasing the Chmp1A protein levels , anacardic acid activated ATM and p53 molecules that suppress the development of tumors. (dreddymd.com)
Dietary1
- Caffeic acid, a dietary phenol from coffee, fruits and vegetables, is an efficient antioxidant. (biomedsearch.com)
Effectively1
- Cashew is mostly composed of anacardic acids used effectively against tooth abscesses. (hktdc.com)
Antioxidants1
- Modern agents include preparations of retinoic acid , ascorbic acid alpha - hydroxy acids , and antioxidants used in conjunction with sunscreens. (tripdatabase.com)
Bacteria1
- Eichbaum claims that a solution of one part anacardic acid to 200,000 parts water to as low as one part in 2,000,000 is lethal to Gram-positive bacteria in 15 minutes in vitro. (wikipedia.org)
Chmp1A1
- When tested on pancreatic cancer cell cultures that silenced the Chmp1A, anacardic acid was not able to suppress cancerous growth. (dreddymd.com)