A piperidine botanical insecticide.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)

Minor tobacco alkaloids as biomarkers for tobacco use: comparison of users of cigarettes, smokeless tobacco, cigars, and pipes. (1/42)

OBJECTIVES: This study (1) determined levels of various tobacco alkaloids in commercial tobacco products. (2) determined urinary concentrations, urinary excretion, and half-lives of the alkaloids in humans; and (3) examined the possibility that urine concentrations of nicotine-related alkaloids can be used as biomarkers of tobacco use. METHODS: Nicotine intake from various tobacco products was determined through pharmacokinetic techniques. Correlations of nicotine intake with urinary excretion and concentrations of anabasine, anatabine, nornicotine, nicotine, and cotinine were examined. By using urinary excretion data, elimination half-lives of the alkaloids were calculated. RESULTS: Alkaloid levels in commercial tobacco products, in milligrams per gram, were as follows: nicotine, 6.5 to 17.5; nornicotine, 0.14 to 0.66; anabasine, 0.008 to 0.030; and anatabine, 0.065 to 0.27. Measurable concentrations of all alkaloids were excreted in the urine of most subjects smoking cigarettes, cigars, and pipes and using smokeless tobacco. Correlations between nicotine intake and alkaloid concentrations were good to excellent. CONCLUSIONS: Anabasine and anatabine, which are present in tobacco but not in nicotine medications, can be used to assess tobacco use in persons undergoing nicotine replacement therapy.  (+info)

Insecticidal and neural activities of candidate photoaffinity probes for neonicotinoid binding sites. (2/42)

Photoreactive derivatives of imidacloprid and its nitromethylene analogue were synthesized as candidate photoaffinity probes for identifying the amino acid residues of nicotinic acetylcholine receptors (nAChRs) that interact with the neonicotinoid insecticides. When the candidate probes were injected into American cockroaches, the nerve cord neural activity initially increased, then ceased and death of the insect followed. Both the nerve cord and toxicity were enhanced by changing the photoreactive substituent from the para position to the meta position on the spacer benzyl moiety. When tested on a Drosophila SAD/chicken beta2 hybrid, recombinant nAChR expressed in Xenopus oocytes, the nitromethylene candidate probes showed agonist activity similar to that previously observed for imidacloprid.  (+info)

Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor. (3/42)

The nicotinic receptor drug candidate, 3-(2,4-dimethoxybenzylidene)-anabaseine (also known as GTS-21; DMXBA), its hydroxy metabolites, and some related analogs were evaluated with the two-electrode voltage-clamp technique in mouse 5-hydroxytryptamine (5-HT)(3A) receptors expressed in Xenopus oocytes. Although DMXBA lacked partial agonist activity, its hydroxy-benzylidene metabolites and related analogs were partial agonists, displaying the following rank order of potency (EC(50)) and apparent efficacy: 5-HT, 0.9 +/- 0.06 microM (100% efficacy) > 3-(2-hydroxy,4-methoxybenzylidene)-anabaseine (2-OH-MBA), 2.0 +/- 0.3 microM (63% efficacy) > 3-(2,4-dihydroxybenzylidene)-anabaseine, 2.6 +/- 0.3 microM (63% efficacy) > 3-(2-methoxy,4-hydroxybenzylidene)-anabaseine, 17.2 +/- 1.0 microM (30% efficacy). To examine the influence of a benzylidene ring hydroxy substituent, the agonist actions of the three possible monohydroxy isomers were examined. The rank order of potency, based on EC(50) determinations, and apparent efficacy was: 3-(2-hydroxybenzylidene)-anabaseine, 20.3 +/- 2.6 microM (63% efficacy) > 3-(4-hydroxybenzylidene)-anabaseine, 32.3 +/- 5.9 microM (14% efficacy) > 3-(3-hydroxybenzylidene)-anabaseine (3-OH-BA) (no agonist activity). Both DMXBA and 3-OH-BA antagonized 5-HT-mediated currents, with IC(50) values of 15.7 +/- 0.9 and 27.5 +/- 4.7 microM, respectively. DMXBA demonstrated both competitive and noncompetitive forms of antagonism over the range of concentrations tested. These results suggest that a hydroxy substituent at the 2' position of the benzene ring is necessary and sufficient for partial agonist activity; substitution at the 4' position with a hydroxy or methoxy group further enhances agonist potency. Because 2-OH-MBA is a primary metabolite of DMXBA, it may contribute to the physiological, biochemical, and behavioral effects of the parent compound when administered in vivo.  (+info)

Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis. (4/42)

1. Pharmacological studies of alpha7 nicotinic acetylcholine receptors are confounded by the fact that rapid desensitization to high agonist concentration causes alpha7 peak responses to occur well in advance of complete solution exchange. For this reason, peak currents are an invalid measure of response to applied agonist concentrations. We show that results comparable to those that have been corrected for instantaneous concentration are obtained if net charge is used as the measure of receptor response. 2. Dose response curves obtained with these methods indicate that alpha7 receptors are approximately 10 fold more sensitive to agonist than previously reported. The agonists, ACh, choline, cytisine, GTS-21, 4OH-GTS-21 and 4-MeO-CA have the same rank order potency for both human and rat receptors: 4-MeO-CA > 4OH-GTS-21 > GTS-21 > cytisine > ACh > choline. However, differences in efficacy exist between rat and human receptors. GTS-21 is more efficacious for rat than human alpha7 receptors and cytosine more efficacious for human than rat alpha7 receptors. 3. Choline is the least potent agonist for both human and rat alpha7, with a potency approximately 10 fold lower than that of ACh. While the EC50 for the activation of alpha7 receptors by choline (400-500 microM) is outside the normal physiological range (10-100 microM), choline can nonetheless produce detectable levels of channel activation in the physiological concentration range. Since these concentrations are relatively non-desensitizing, the contribution of choline-activated alpha7 receptor current may play a significant role in the regulation of calcium homeostasis in alpha7-expressing neurons.  (+info)

Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles. (5/42)

BACKGROUND: Assessment of nicotine metabolism and disposition has become an integral part of nicotine dependency treatment programs. Serum nicotine concentrations or urine cotinine concentrations can be used to guide nicotine patch dose to achieve biological concentrations adequate to provide the patient with immediate relief from nicotine withdrawal symptoms, an important factor in nicotine withdrawal success. Absence of nicotine metabolites and anabasine can be used to document abstinence from tobacco products, an indicator of treatment success. METHODS: The procedure was designed to quantify nicotine, cotinine, trans-3'-hydroxycotinine, anabasine, and nornicotine in human serum or urine. The technique required simple extraction of the sample with quantification by HPLC-tandem mass spectrometry. RESULTS: The procedure for simultaneous analysis of nicotine, its metabolites, and tobacco alkaloids simultaneously quantified five different analytes. Test limit of quantification, linearity, imprecision, and accuracy were adequate for clinical evaluation of patients undergoing treatment for tobacco dependency. The test readily distinguished individuals who had no exposure to tobacco products from individuals who were either passively exposed or were abstinent past-tobacco users from those who were actively using a tobacco or nicotine product. CONCLUSIONS: Nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine, and anabasine can be simultaneously and accurately quantified in either serum or urine by HPLC-tandem mass spectrometry with imprecision <10% at physiologic concentrations and limits of quantification ranging from 0.5 to 5 micro g/L. Knowledge of serum or urine concentrations of these analytes can be used to guide nicotine replacement therapy or to assess tobacco abstinence in nicotine dependency treatment. These measurements are now an integral part of the clinical treatment and management of patients who wish to overcome tobacco dependence.  (+info)

Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy. (6/42)

In this study we determined urine concentration of the tobacco alkaloids anabasine and anatabine, nicotine and its metabolites cotinine, and nornicotine in 99 cigarette smokers and 205 smokeless tobacco users. We also investigated the possibility that anabasine and anatabine can be used as biomarkers for tobacco use during nicotine replacement therapy. Urine samples and data on self-reported tobacco use were obtained from subjects enrolled in tobacco cessation programs. Urine concentrations of tobacco alkaloids and metabolites were measured and correlated with self-reported tobacco use. Concentrations of anabasine and anatabine were used to validate abstinence in smokeless tobacco users who used nicotine gum as part of the therapy. Correlations of alkaloid concentration with self-reported tobacco use before treatment ranged from fair to poor. In subjects abstaining from smokeless tobacco but using nicotine gum, anabasine and anatabine levels were below the cut-point of 2 ng/ml despite high concentrations of nicotine and cotinine resulting from nicotine gum use. Anabasine and anatabine concentrations in urine can be used to validate abstinence or measure the extent of tobacco use in persons undergoing nicotine replacement therapy.  (+info)

Regulation of neuronal function by choline and 4OH-GTS-21 through alpha 7 nicotinic receptors. (7/42)

A unique feature of alpha7 nicotinic acetylcholine receptor physiology is that, under normal physiological conditions, alpha7 receptors are constantly perfused with their natural selective agonist, choline. Studying neurons of hypothalamic tuberomammillary (TM) nucleus, we show that choline and the selective alpha7 receptor agonist 4OH-GTS-21 can regulate neuronal functions directly, via activation of the native alpha7 receptors, and indirectly, via desensitizing those receptors or transferring them into a state "primed" for desensitization. The direct action produces depolarization and thereby increases the TM neuron spontaneous firing (SF) rate. The regulation of the spontaneous firing rate is robust in a nonphysiological range of choline concentrations >200 microM. However, modest effects persist at concentrations of choline that are likely to be attained perineuronally under some conditions (20-100 microM). At high physiological concentration levels, the indirect choline action reduces or even eliminates the responsiveness of alpha7 receptors and their availability to other strong cholinergic inputs. Similarly to choline, 4OH-GTS-21 increases the TM neuron spontaneous firing rate via activation of alpha7 receptors, and this regulation is robust in the range of clinically relevant concentrations of 4OH-GTS-21. We conclude that factors that regulate choline accumulation in the brain and in experimental slices such as choline uptake, hydrolysis of ACh, membrane phosphatidylcholine catabolism, and solution perfusion rate influence alpha7 nAChR neuronal and synaptic functions, especially under pathological conditions such as stroke, seizures, Alzheimer's disease, and head trauma, when the choline concentration in the CSF is expected to rise.  (+info)

Components of cigarette smoke inhibit expansion of oocyte-cumulus complexes from porcine follicles. (8/42)

The role of alkaloids in cigarette smoke was investigated in the cumulus expansion of oocyte-cumulus complexes (OCC) isolated from large antral porcine follicles. Suppression of the cumulus expansion stimulated by FSH was observed in the presence of different concentration of cadmium, anabasine and nicotine but not its metabolite cotinine. There were comparable inhibitory effects of cadmium and nicotine on the synthesis and accumulation of hyaluronic acid in the cell/matrix compartment of OCC. The inhibitory effect of tested compounds on the cumulus expansion was accompanied by decreased progesterone synthesis by cumulus cells during 42 h incubation of OCC with FSH. The results suggest that cigarette smoking may affect intrafollicular processes, which are responsible for normal ovulation and fertilization.  (+info)

Anabasine is a type of toxic alkaloid that can be found in certain plants, including the leaves of the tobacco plant Nicotiana glauca (also known as tree tobacco). It has a similar structure to nicotine and can have similar physiological effects, such as stimulating the nervous system and increasing heart rate. However, anabasine is generally considered to be more toxic than nicotine.

Anabasine can also be produced synthetically in a laboratory. It has been used in research as a tool for studying the mechanisms of nicotinic acetylcholine receptors, which are important targets for drugs that affect the nervous system.

In terms of medical definitions, anabasine is not a term that is commonly used in clinical medicine. It is more likely to be encountered in the context of research or toxicology.

Nicotine is defined as a highly addictive psychoactive alkaloid and stimulant found in the nightshade family of plants, primarily in tobacco leaves. It is the primary component responsible for the addiction to cigarettes and other forms of tobacco. Nicotine can also be produced synthetically.

When nicotine enters the body, it activates the release of several neurotransmitters such as dopamine, norepinephrine, and serotonin, leading to feelings of pleasure, stimulation, and relaxation. However, with regular use, tolerance develops, requiring higher doses to achieve the same effects, which can contribute to the development of nicotine dependence.

Nicotine has both short-term and long-term health effects. Short-term effects include increased heart rate and blood pressure, increased alertness and concentration, and arousal. Long-term use can lead to addiction, lung disease, cardiovascular disease, and reproductive problems. It is important to note that nicotine itself is not the primary cause of many tobacco-related diseases, but rather the result of other harmful chemicals found in tobacco smoke.

Alkaloids are a type of naturally occurring organic compounds that contain mostly basic nitrogen atoms. They are often found in plants, and are known for their complex ring structures and diverse pharmacological activities. Many alkaloids have been used in medicine for their analgesic, anti-inflammatory, and therapeutic properties. Examples of alkaloids include morphine, quinine, nicotine, and caffeine.

... is present in trace amounts in tobacco smoke, and can be used as an indicator of a person's exposure to tobacco smoke ... Anabasine is a pyridine and piperidine alkaloid found in the Tree Tobacco (Nicotiana glauca) plant, as well as in the close ... The intravenous LD50 of anabasine ranges from 11 mg/kg to 16 mg/kg in mice, depending on the enantiomer. B. Bhatti, et al. made ... Anabasine is a nicotinic acetylcholine receptor agonist. In high doses, it produces a depolarizing block of nerve transmission ...
nicotine anabasine ricinine "Pyridine Alkaloids". Cornell University, Department of Animal Science. Entry on Pyridin. at: Römpp ... Examples include nicotine and anabasine which are found in plants of the genus Nicotiana including tobacco. Alkaloids with a ... The most important examples of pyridine alkaloids are the nicotine and anabasine, which are found in tobacco, the areca ...
It is structurally similar to nicotine and anabasine. Similarly, it has been shown to act as an agonist on most nicotinic ...
... the accumulation of anabasine as a major alkaloid." Xiphotheca comprises the following species: Xiphotheca fruticosa (L.) A. L ...
Karadsheh N, Kussie P, Linthicum DS (March 1991). "Inhibition of acetylcholinesterase by caffeine, anabasine, methyl ...
Karadsheh, N; Kussie, P; Linthicum, DS (1991). "Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine ...
... anabasine, methyl pyrrolidine and their derivatives". Toxicology Letters. 55 (3): 335-42. doi:10.1016/0378-4274(91)90015-X. ...
The alkaloid anabasine, a close structural relative of nicotine, is named for the plant from which it was first isolated: the ... Anabasine sulphate was a widely used botanical insecticide in the former Soviet Union until the 1970s. [Note: the use of the ... Recently, anabasine-related alkaloids have also been isolated from the venom of an ant belonging to the genus Aphaenogaster and ... Mizrachi, N; Levy, S; Goren, ZQ (May 2000). "Fatal poisoning from Nicotiana glauca leaves: identification of anabasine by gas- ...
It contains the toxic alkaloid anabasine and ingestion of the leaves can be fatal. It is being investigated for use as a ...
The alkaloid anabasine was named for this toxic species, from which it was first isolated by Orechoff and Menschikoff in the ... Anabasine was widely used as an insecticide in the former Soviet Union until 1970. "Anabasis aphylla L." Plants of the World ...
Anabasine is also the active principle responsible for deaths from poisoning caused by the leaves of Nicotiana glauca, the Tree ... The Nicotine-related alkaloid Anabasine was named for the toxic Central Asiatic species Anabasis aphylla - from which it was ... Mizrachi, N.; Levy, S.; Goren, Z. Q. (2000). "Fatal Poisoning from Nicotiana glauca Leaves: Identification of Anabasine by Gas- ...
Campbell, F. L.; Sullivan, W. N.; Smith, C. R. (1933-04-01). "The Relative Toxicity of Nicotine, Anabasine, Methyl Anabasine, ...
Pyridyl functional groups present in minute amounts include anabasine, myosmine, cotinine and 2, 3′-bipyridyl. Indole alkaloids ...
Anabasine Romanelli MN, Gratteri P, Guandalini L, Martini E, Bonaccini C, Gualtieri F (June 2007). "Central nicotinic receptors ...
Important phytochemicals include p-coumaric acid, quercetin, abscisic acid, anabasine, caffeine, gallic acid, kaempferol, and ...
The project was centered on, but not restricted to, the use of anabasine (an alkaloid), scopolamine and mescaline. It was the ...
"Effect of gibberellic acid applications to leaves of Nicotiana on nornicotine, anabasine, metanicotine, oxynicotine, and ...
... anabasine, and anatabine, which are very carcinogenic, can be found in e-cigarette refill liquids. The molecules can lead to ... anabasine, anatabine, myosmine and beta-nicotyrine. The health implications of nicotine-related impurities are not known. A ...
The major components found in the secretions of Aphaenogaster rudis include anabaseine, anabasine, and 2,3'-bipyridyl, though ...
... such as salts of nicotine and anabasine, were used as insecticides. Their use was limited by their high toxicity to humans. ...
Some e-liquids contain tobacco alkaloids such as nornicotine, anabasine, or anatabine, and TSNAs, such as N-nitrosonornicotine ... anabasine, myosmine, and beta-nicotyrine. The TSNAs N-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone ...
The molecular formula C10H14N2 (molar mass: 162.23 g/mol, exact mass: 162.1157 u) may refer to: Anabasine Nicotine ...
... anabasine MeSH D03.383.621.080 - betalains MeSH D03.383.621.080.500 - betacyanins MeSH D03.383.621.080.750 - betaxanthins MeSH ...
Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of ...
... allosamidin allyl isothiocyanate allyxycarb alpha-cypermethrin alpha-endosulfan amidithion aminocarb amiton amitraz anabasine ...
... selective potent full agonist with nootropic and neuroprotective properties Anabasine Acetylcholine Nicotine Epiboxidine ...
The hydrochloride and sulfate salts become optically inactive if heated in a closed vessel above 180 °C. Anabasine is a ...
... and anabasine making up nearly all the rest. These compounds are thought to be biologically active, and part of plants' natural ...
Despite containing enough nicotine and/or other compounds such as germacrene and anabasine and other piperidine alkaloids ( ...
Despite containing enough nicotine and other compounds such as germacrene and anabasine and other piperidine alkaloids (varying ...
Anabasine is present in trace amounts in tobacco smoke, and can be used as an indicator of a persons exposure to tobacco smoke ... Anabasine is a pyridine and piperidine alkaloid found in the Tree Tobacco (Nicotiana glauca) plant, as well as in the close ... The intravenous LD50 of anabasine ranges from 11 mg/kg to 16 mg/kg in mice, depending on the enantiomer. B. Bhatti, et al. made ... Anabasine is a nicotinic acetylcholine receptor agonist. In high doses, it produces a depolarizing block of nerve transmission ...
URXANBT - Anabasine, urine (ng/mL). Variable Name: URXANBT. SAS Label: Anabasine, urine (ng/mL). English Text: Anabasine, urine ... URDANBLC - Anabasine, urine Comment Code. Variable Name: URDANBLC. SAS Label: Anabasine, urine Comment Code. English Text: ... Anabasine, urine Comment Code. Target: Both males and females 3 YEARS - 150 YEARS. Code or Value. Value Description. Count. ... Lastly, anatabine and anabasine are nicotine analogs in tobacco product, and are precursors for nitrosamines. Therefore, levels ...
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Anabasine. Anatabine. Cotinine. Cotinine-n-oxide. Hydroxycotinine. Trans-3-hydroxycotinine. 1-(3-Pyridyl)-1-butanol-4- ...
Dive into the research topics of Synthesis and conformational analysis of a bridged anabasine and related compounds. A nuclear ... Synthesis and conformational analysis of a bridged anabasine and related compounds. A nuclear magnetic resonance spectroscopy ...
Like F. Goffman said it doesnt contain that much nicotine if any at all, mostly Anabasine. bouncing bear botanicals ...
3). The Diepsloot site showed high peak intensities for caffeine, cotinine, 2-phenethylamine, anabasine and nicotine. The most ...
When nicotine enters the body, it is broken down into more than 20 different substances, including cotinine, anabasine, and ...
Anabasine [Mass/volume] in Urine. 33916-8. Trans-3-Hydroxycotinine [Mass/volume] in Urine. ...
Estimates of tobacco use by wastewater analysis of anabasine and anatabine. BJ Tscharke, JM White, JP Gerber ...
At 15 days, cytisine and the cytisine/anabasine combination were more effective than anabasine alone. ... 24 The author allocated 62 smokers to anabasine, cytisine (buccal film rather than tablets) or their combination. ...
Holobody - 011 (anabasine starlight mix). ÑERO - Escala. Valeda - Safe Now. Ouri - Free State of Chaos. Moonstarr - AC 130. ...
The biosynthesis of anabasine in Nicotiana transformed root cultures was examined by the feeding experiments with (R)-[1-2H]- ... This experiment has determined the optical purity of anabasine in Nicotiana transformed root cultures. These results are ...
The caprina both unswayable oblivious(p) offending Internet an seems minus non-Attic affirm atop anyone anabasine. Ontogenic ... offending viagra schneller versand an seems minus non-Attic affirm atop anyone anabasine. Costal unheavily explode an frizzier ...
... of at least 1month of continuous abstinence collected at 2months post-enrolment and verified by saliva cotinine or anabasine. ...
Anabasine [Wiki]. ; Caswell No. 051. ; DL-Anabasine. ; EINECS:207-791-3. ; Neonicotine. ; Pyridine, 3-(2-piperidinyl)-(CAS). ; ... R,S)-Anabasine. ; (±)-Anabasine. ; 3-(2-Piperidinyl)pyridine(IUPAC). ; 3-(piperidin-2-yl)pyridine. ; 3-piperidin-2-ylpyridine( ...
ST069297 Anabasine Hydrochloride. Anabasine Hydrochloride. 494-52-0. MFCD01570966. 3-(2-piperidyl)pyridine. ...
... anatabine and anabasine) in the tobacco plant to be decreased or increased through genetic engineering or plant breeding. 22nd ...
Lastly, anabasine is an alkaloid found in tobacco [11]. However, unlike cotinine, it is not present in FDA-approved nicotine ... The primary barrier to more widespread use of anabasine is the cost of the assay; in addition, it is not easily available in ... Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy. Cancer Epidemiol Biomark Prev. 2002; ... Specifically, biomarkers such as carbon monoxide, cotinine, and anabasine, measured at regular intervals, can provide ...
Note to tobacco users: The lab tests usually look for nicotine, cotinine, and anabasine, which indicate whether youve smoked ...
The alpha-3 beta-4 nicotinic receptor, also known as the α3β4 receptor and the ganglion-type nicotinic receptor,[1] is a type of nicotinic acetylcholine receptor, consisting of α3 and β4 subunits.[2][3] It is located in the autonomic ganglia[4] and adrenal medulla,[5] where activation yields post- and/or presynaptic excitation,[3] mainly by increased Na+ and K+ permeability. As with other nicotinic acetylcholine receptors, the α3β4 receptor is pentameric [(α3)m(β4)n where m + n = 5]. The exact subunit stoichiometry is not known and it is possible that more than one functional α3β4 receptor assembles in vivo with varying subunit stoichiometries. Ligands which inhibit the α3β4 receptor have been shown to modulate drug-seeking behavior,[6] making α3β4 a promising target for the development of novel antiaddictive agents. ...
Anabasine [13078-04-1] Verfügbarkeit: Bitte kontaktieren Sie uns Produkt anzeigen ID: 23385847 ...
Free resources to help eligible residents quit smoking or using other tobacco products.
Dive into the research topics of Characterisation of nicotine and related compounds using electrospray ionisation with ion trap mass spectrometry and with quadrupole time-of-flight mass spectrometry and their detection by liquid chromatography/electrospray ionisation mass spectrometry. Together they form a unique fingerprint. ...
Barbieri RL, Gochberg J, Ryan KJ: Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. J Clin ...
Anabasine 2.4. Cell lifestyle Aorta was taken out and washed of unwanted fat and endothelium within a sterile environment with ... In other tests, chemerin-9 (1 M) was Anabasine incubated with tissue for 0 or 5 min in the isolated tissues bath, and tissue ... Regular male Sprague-Dawley rats (225C300 g; Charles River Laboratories, Inc., Portage, MI, USA) Anabasine had been used. To ... Isometric contraction Aortic bands [cleaned out of perivascular Anabasine adipose cells (as an endogenous chemerin resource), ...
Anabasine D3.132.66. Andersen Syndrome C16.131.240.400.715.70. C23.550.73.547.70. Anethole Trithione D2.886.753.77. Angina ...
Anabasine D3.132.66. Andersen Syndrome C16.131.240.400.715.70. C23.550.73.547.70. Anethole Trithione D2.886.753.77. Angina ...
Anabasine D3.132.66. Andersen Syndrome C16.131.240.400.715.70. C23.550.73.547.70. Anethole Trithione D2.886.753.77. Angina ...
  • When nicotine enters the body, it is broken down into more than 20 different substances , including cotinine, anabasine, and nornicotine. (medicalnewstoday.com)
  • Specifically, biomarkers such as carbon monoxide, cotinine, and anabasine, measured at regular intervals, can provide clinicians with much clearer, clinically relevant and actionable assessments of current tobacco use by their patients. (biomedcentral.com)
  • Blood tests can detect nicotine as well as its metabolites, including cotinine and anabasine. (emojicut.com)
  • Nicotine tests can be conducted using both qualitative and quantitative means that detect nicotine, cotinine, and anabasine - a breakdown product of nicotine. (wotofo.com)
  • Previously, the identification of ancient plant residues relied on the detection of a limited number of biomarkers, such as nicotine, anabasine, cotinine and caffeine. (wsu.edu)
  • Lastly, anatabine and anabasine are nicotine analogs in tobacco product, and are precursors for nitrosamines. (cdc.gov)
  • 22nd Century is a plant biotechnology company whose proprietary technology allows for the levels of nicotine and other nicotinic alkaloids (e.g., nornicotine, anatabine and anabasine) in the tobacco plant to be decreased or increased through genetic engineering or plant breeding. (advfn.com)
  • Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy. (ncats.io)
  • Although tree tobacco does contain about one percent nicotine, it also has about 10 percent of anabasine, the alkaloid found in its leaves, stems and flowers. (americanoutdoor.guide)
  • According to Dr. James Adams, co-author of Healing with Medicinal Plants of the West , "Anabasine is a compound similar in structure and activity to nicotine, but more toxic in terms of seizure induction. (americanoutdoor.guide)
  • The flute has been well sealed, inside and out, so that neither of the alkaloids in Nicotiana glauca (nicotine and anabasine) come into contact with the player. (dryadflutes.com)
  • Gas chromatographic-mass spectrometric method for determination of anabasine, anatabine and other tobacco alkaloids in urine of smokers and smokeless tobacco users. (ncats.io)
  • Anabasine and anatabine are minor alkaloids in tobacco products and are precursors for tobacco-specific nitrosamines (TSNAs). (cdc.gov)
  • This is the first time that anabasine and anatabine are reported for urine collected from a U.S. population-representative sample of NHANES study participants, providing a snapshot of exposure levels for adults who smoked during 2013-2014. (cdc.gov)
  • Anabasine is a pyridine and piperidine alkaloid found in the Tree Tobacco (Nicotiana glauca) plant, as well as in the close relative of the common tobacco plant (Nicotiana tabacum). (wikipedia.org)
  • The biosynthesis of anabasine in Nicotiana transformed root cultures was examined by the feeding experiments with (R)-[1-2H]- and (S)-[1-2H]cadaverine and analysis by 2H n. m. r. spectroscopy. (gla.ac.uk)
  • This experiment has determined the optical purity of anabasine in Nicotiana transformed root cultures. (gla.ac.uk)
  • The concentrations of urinary anabasine and anatabine were measured in a representative sample of U.S. adults who smoked cigarettes (N = 770) during the 2013-2014 National Health and Nutrition Examination Survey (NHANES) study cycle, which was the first cycle where urinary anabasine and anatabine data became available. (cdc.gov)
  • Weighted geometric means (GM) and geometric least squares means (LSM) with 95% confidence intervals were calculated for urinary anabasine and anatabine categorized by tobacco-use status [cigarettes per day (CPD) and smoking frequency] and demographic characteristics. (cdc.gov)
  • Compared with non-daily smoking, daily smoking was associated with higher GMs for urinary anabasine (1.41 ng/mL vs. 6.28 ng/mL) and anatabine (1.62 ng/mL vs. 9.24 ng/mL). (cdc.gov)
  • Anabasine is a nicotinic acetylcholine receptor agonist. (wikipedia.org)
  • Isometric contraction Aortic bands [cleaned out of perivascular Anabasine adipose cells (as an endogenous chemerin resource), and endothelium-denuded] had been mounted in cells baths Anabasine for isometric pressure recordings using Lawn transducers (Feet03) and PowerLab data acquisitions operating Graph 7.0 (ADInstruments, Colorado Springs, CO, USA). (giknet.org)
  • Anabasine is present in trace amounts in tobacco smoke, and can be used as an indicator of a person's exposure to tobacco smoke. (wikipedia.org)
  • Smoking 20 CPD was associated with 3.6 higher anabasine GM and 4.8 higher anatabine GM compared with smoking <10 CPD. (cdc.gov)
  • Diacetyl Nitrosamine (a known carcinogen), Diethy Glycol (used in antifreeze and known to be toxic to humans), Anabasine (an insecticide) and Myosmine (harms the DNA found in all cells). (drpoz.com)
  • Lastly, anatabine and anabasine are nicotine analogs in tobacco product, and are precursors for nitrosamines. (cdc.gov)
  • Cis-N-oxide, trans-N-oxide, myosmine, anatabine and anabasine were the most common additional compounds found. (nih.gov)
  • Anabasine and anatabine are minor alkaloids in tobacco products and are precursors for tobacco-specific nitrosamines (TSNAs). (nih.gov)
  • The contents of nornicotine, anabasine, NNN, NNK, NAT, total TSNAs and the nicotine of mainstream cigarette smoke decreased, and the contents of amino acids and the precursors of alkaloids increased in grafted tobacco. (biomedcentral.com)
  • All parts of the plant, especially its leaves, contain the toxic alkaloids nicotine and anabasine, and can be fatal if eaten. (securitest-grigny.fr)
  • Preceding the improvement of many moderately low-poisonous engineered pesticides, a few alkaloids, like salts of nicotine and anabasine, were utilized as insect poisons. (purkh.com)
  • Anabasine is a pyridine and piperidine alkaloid found in the Tree Tobacco (Nicotiana glauca) plant, as well as in the close relative of the common tobacco plant (Nicotiana tabacum). (wikipedia.org)
  • In some e-cigarettes, "Tobacco-specific impurities suspected of being harmful to humans - anabasine, myosmine, and ß-nicotyrine - were detected in a majority of the samples tested. (moinur.ca)
  • Two examples are anabasine and nornicotine, which are present in tobacco products, but not nicotine replacement therapies. (clinlabnavigator.com)
  • The presence of anabasine and nornicotine anabasine greater than 10 ng/mL or nornicotine greater than 30 ng/mL in urine indicates active use of a tobacco product, regardless of whether the individual is using nicotine replacement therapy. (clinlabnavigator.com)
  • The presence of nornicotine without anabasine is consistent with use of nicotine replacement products. (clinlabnavigator.com)
  • Neither anabasine nor nornicotine accumulates from passive exposure. (clinlabnavigator.com)
  • Efficient enantioselective syntheses of (S)- and R-(+)-nornicotine, (S)-and R-(+)-anabasine, and (S)-and R-(+)-anatabine have been developed, affording isomers in high enantiomeric excess. (uky.edu)
  • Anabasine is found in tobacco, but it isn't found in any other nicotine-replacement products. (quickfixsynthetic.com)
  • Chloroform extract of the drug, which was devoid of anabasine, exhibited prominent sedative effect in rat. (indianmedicinalplants.info)
  • If you test positive for anabasine, it means that you're still using some form of tobacco product. (quickfixsynthetic.com)

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