Effects of single administration of a phosphodiesterase III inhibitor during cardiopulmonary bypass: comparison of milrinone and amrinone. (1/66)

The effects of phosphodiesterase III (PDE III) inhibitors administered after aortic declamping during cardiopulmonary bypass (CPB) for open heart surgery were investigated. Ten patients (group M) were administered milrinone (50 microg/kg) after aortic declamping during CPB, 10 patients were administered amrinone (1 mg/kg) at the same time during their surgery (group A), and 10 patients served as controls with no drug administered (group C). Soon after bolus infusion of the PDE III inhibitor, perfusion pressure dropped significantly in groups M and A. However, after release of CPB and at the end of surgery, there was no difference in aortic pressure between the 3 groups. There were also no differences between the groups in heart rate, pulmonary artery pressure, and pulmonary capillary wedge pressure. After weaning from CPB, the cardiac index was high and systemic vascular resistance index was low in groups M and A. There were no significant differences in the need for additional catecholamines and time for rewarming between groups. No adverse reactions were observed. A single administration of a PDE III inhibitor during CPB was useful for post-CPB management of patients undergoing open heart surgery. Amrinone reduced perfusion pressures more than milrinone, but cardiac indices and aortic pressures after weaning from CPB showed no differences between group M and group A patients.  (+info)

Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1. (2/66)

The effects of amrinone, a selective phosphodiesterase III inhibitor, on liver ischaemia reperfusion injury have not yet been clarified. Forty-five patients with hepatocellular carcinoma who underwent partial liver resection using Pringle's manoeuvre were studied. Patients were divided into three groups: those given amrinone, those given prostaglandin E1 (PGE1) and those not treated (controls). An indocyanine green (ICG) clearance test was performed before the operation and three times during surgery: just before induction of liver ischaemia, just after liver resection and 60 min after reperfusion. Blood lactate and base excess were measured at the same times. Systolic and diastolic arterial pressure, heart rate, cardiac index and oesophageal temperature were monitored. Aminotransferase levels were recorded the day before surgery, 1 h after operation and on the first and third postoperative days. These data were compared between groups. The ICG elimination rate, lactate and base excess in the amrinone group differed significantly from those in controls during the observation period (P = 0.03, P = 0.04 and P = 0.03, respectively). The differences between the PGE1 and control groups were not significant. There were no significant differences between the groups in perioperative vital signs, cardiac index or postoperative aminotransferase. Amrinone enhanced intraoperative ICG elimination in cirrhotic patients who underwent liver resection.  (+info)

Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro. (3/66)

An experimental study was done to examine a potential role of phosphodiesterase (PDE) inhibitors in the treatment of diabetic erectile dysfunction. Relaxant effect of specific PDE inhibitors were measured in strips of corpus cavernosum smooth muscle taken from control and diabetic groups. Diabetes mellitus was induced in New Zealand white rabbits using alloxan. Penises excised from diabetic rabbits 8 weeks after the induction of diabetes mellitus. In the organ bath strips from control and diabetic rabbit corpus cavernosum were precontracted and increasing doses of several PDE inhibitors were added. In the precontracted rabbit cavernous tissue, sulmazole and zaprinast specific PDE V inhibitors were equally potent and efficacious in vitro but amrinone, a specific PDE III inhibitor, exhibits low relaxant effects. All PDE inhibitors tested showed a similar relaxation effect on corpus cavernosum smooth muscle from control and 8-week diabetic rabbits. The present study provides the possibility of using selective PDE III and V inhibitors in the treatment of diabetic impotence.  (+info)

Lack of role for nitric oxide in cholinergic modulation of myocardial contractility in vivo. (4/66)

Despite intensive investigation, the role of nitric oxide (NO) in cholinergic modulation of myocardial contractility remains unresolved. The left anterior descending coronary artery of 34 anesthetized, open-chest dogs was perfused via an extracorporeal circuit. Segmental shortening (SS) was measured with ultrasonic crystals and coronary blood flow (CBF) was measured with an ultrasonic flow transducer. An intracoronary infusion of ACh (20 microg/min) was performed, with CBF held constant, under baseline and during dobutamine, CaCl(2), or amrinone at doses increasing SS by approximately 50% (10 microg/min, 15 mg/min, and 300 microg/min ic, respectively). ACh-induced responses during dobutamine were also assessed following treatment with the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME; 300 microg/min ic for 15 min). The effects of sodium nitroprusside (SNP; 80 microg/min ic), an exogenous NO donor, bradykinin (2.5 microg/min ic), a nonmuscarinic releaser of endothelial NO, and bilateral vagal stimulation (before and after L-NAME) were evaluated during dobutamine. ACh had no effect on SS under baseline or during CaCl(2), but it decreased SS during dobutamine or amrinone (-23 +/- 4% and -30 +/- 5%, respectively). Vagal stimulation also reduced SS during dobutamine. L-NAME did not alter the ACh- or vagal-induced decreases in SS during dobutamine. Neither SNP nor bradykinin affected SS during dobutamine. In conclusion, ACh and vagal stimulation have a negative inotropic effect during stimulation of the beta-adrenergic receptors that is independent of NO. The persistence of this effect during amrinone suggests that a mechanism downstream from adenylate cyclase is involved.  (+info)

In contrast to forskolin and 3-isobutyl-1-methylxanthine, amrinone stimulates the cardiac voltage-sensitive release mechanism without increasing calcium-induced calcium release. (5/66)

The objective of this study was to determine whether the voltage-sensitive release mechanism (VSRM) can be stimulated independently from Ca(2+)-induced Ca(2+) release (CICR) by drugs that elevate intracellular cAMP. Contractions were measured in voltage-clamped guinea pig ventricular myocytes at 37 degrees C. Na(+) current was blocked. We compared effects of agents that elevate cAMP through activation of adenylyl cyclase (1 microM forskolin), nonspecific inhibition of phosphodiesterases (PDEs) [100 microM 3-isobutyl-1-methylxanthine (IBMX)], and selective inhibition of PDE III (100-500 microM amrinone) on contractions initiated by the VSRM and CICR. Forskolin and IBMX significantly increased peak Ca(2+) current and CICR. In addition, these agents also markedly increased contractions elicited by test steps from -65 to -40 mV, which activate the VSRM. However, because these steps also induced inward current in the presence of forskolin or IBMX, CICR could not be excluded. In contrast, amrinone caused a large, concentration-dependent increase in VSRM contractions but had no effect on CICR contractions or Ca(2+) current. Sarcoplasmic reticulum Ca(2+), assessed by rapid application of caffeine (10 mM), was increased only modestly by all three drugs. Normalization of contractions to caffeine contractures indicated that amrinone increased fractional release by the VSRM, but not CICR. Forskolin and IBMX increased fractional release elicited by steps to -40 mV. Increases in CICR induced by forskolin and IBMX were proportional to caffeine contractures. Thus, positive inotropic effects of cAMP on VSRM contractions may be compartmentalized separately from effects on Ca(2+) current and CICR.  (+info)

Amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures. (6/66)

We investigated the effects of i.v. amrinone on intraoperative changes of core temperature during deliberate mild hypothermia for neurosurgery. The patients in a control group (n=10) did not receive amrinone and patients in the amrinone group (n=10) received amrinone 5 microg kg(-1) min(-1) after a loading dose of 1.0 mg kg(-1). Anaesthesia was maintained with nitrous oxide in oxygen, propofol and fentanyl. After the induction of anaesthesia, patients were cooled and tympanic membrane temperature was maintained at 34.5 degrees C. After completion of the main surgical procedures, patients were rewarmed in the operating room. Tympanic membrane temperatures between 30 and 90 min after cooling were significantly lower in the amrinone group than in the control group. During cooling, the times taken to cool to 35 degrees C and to the lowest temperature were significantly shorter in the amrinone group than in the control group. These results suggest that i.v. amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures.  (+info)

High-dose amrinone is required to accelerate rewarming from deliberate mild intraoperative hypothermia for neurosurgical procedures. (7/66)

BACKGROUND: Since the time available to provide the cooling and rewarming is limited during deliberate mild hypothermia, the technique to accelerate the cooling and rewarming rate of core temperature has been studied. Amrinone has been reported to accelerate the cooling rate but not the rewarming rate of core temperature during deliberate mild hypothermia. The failure of amrinone effect on the rewarming rate might be due to an insufficient dose of amrinone during hypothermic conditions. The authors therefore tested whether higher doses of amrinone can accelerate the rewarming rate of core temperature during deliberate mild hypothermia for neurosurgery. METHODS: After institutional approval and informed consent, 30 patients were randomly assigned to one of three groups. Patients in the control group (n = 10) did not receive amrinone; patients in the AMR 15 group (n = 10) received 15 microg x kg(-1) x min(-1) amrinone with a 1.0-mg/kg loading dose of amrinone at the beginning of cooling; and patients in the ReAMR group (n = 10) received 5 microg x kg(-1) x min(-1) amrinone with 1.0-mg/kg loading and reloading doses of amrinone at the beginning of cooling and rewarming, respectively. Administration of amrinone was started just after the induction of cooling and continued until the end of anesthesia. Anesthesia was maintained with nitrous oxide in oxygen, propofol, and fentanyl. After induction of anesthesia, patients were cooled, and tympanic membrane temperature was maintained at 34.5 degrees C. After completion of the main surgical procedures, patients were actively rewarmed and extubated in the operating room. RESULTS: The cooling and rewarming rates of core temperature were both significantly faster in both amrinone groups than in the control group. During the cooling and rewarming periods, forearm minus fingertip temperature gradient was significantly smaller in both amrinone groups than in the control group. During the rewarming period, heart rate and mean arterial pressure in the AMR 15 group were significantly faster and lower, respectively, than in the control group. Systemic vascular resistance in the AMR 15 group was smaller than in the control group throughout the study; on the other hand, only the value after the start of rewarming in the ReAMR group was smaller than in the control group. CONCLUSIONS: Amrinone at an infusion rate of 15 or 5 microg x kg(-1) x min(-1) with a reloading at the beginning of rewarming accelerated the rewarming rate of core temperature during deliberate mild hypothermia. This suggests that high-dose amrinone is required to accelerate rewarming from deliberate mild intraoperative hypothermia for neurosurgical procedures.  (+info)

Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. (8/66)

BACKGROUND: Mounting evidence links systemic and local inflammatory cytokine production to myocardial dysfunction and injury occurring during ischemia-reperfusion, cardiopulmonary bypass, and heart failure. Phosphodiesterase inhibitors (PDEIs), used frequently in these states, can modulate inflammatory signaling. The mechanisms for these effects are unclear. We therefore examined the effects of 2 commonly used PDEIs, amrinone and milrinone, on cardiac cell inflammatory responses. METHODS AND RESULTS: Primary rat cardiomyocyte cultures were treated with endotoxin (LPS) or tumor necrosis factor-alpha (TNF-alpha), alone or in the presence of clinically relevant concentrations of amrinone or milrinone. Regulation of nuclear factor-kappa B (NFkappaB), nitric oxide synthase and cyclooxygenase isoforms, and cytokine production were assessed by electrophoretic mobility shift assays, Western immunoblotting, and enzyme-linked immunoassays, respectively. Both LPS and TNF-alpha induced significant NFkappaB activation, cyclooxygenase-2 (COX-2) expression, and inducible NO synthase (iNOS) and cytokine production; with the exception of COX-2 expression, all were significantly reduced by amrinone, beginning at concentrations of 10 to 50 micro mol/L. In contrast, milrinone increased nuclear NFkappaB translocation, iNOS and COX-2 expression, and cardiomyocyte production of interleukin-1beta. Cell-permeable cAMP increased inflammatory gene expression, whereas cell-permeable cGMP had no effect, indicating that the effects of amrinone were not due to phosphodiesterase inhibition. Similar results were seen in macrophages and coronary vascular endothelial cells. CONCLUSIONS: Both amrinone and milrinone have significant effects on cardiac inflammatory signaling. Overall, amrinone reduces activation of the key transcription factor NFkappaB and limits the production of pro-inflammatory cytokines, whereas milrinone does not.  (+info)

*Amrinone

Both inotropic and lusitropic effects are the reason why amrinone is used to treat heart failure. Amrinone decreases the ... There is a net decrease in myocardial wall tension, and O2 consumption when using amrinone. Amrinone also has beneficial ... Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR ... Amrinone should only be diluted with normal saline or 1/2 normal saline; no dextrose solutions should be used. Furosemide ...

*PDE3 inhibitor

Amrinone, milrinone and enoximone are used clinically for short-term treatment of cardiac failure in the presence of ... Approved PDE3 inhibitors include the following: amrinone cilostazol milrinone enoximone pimobendane (approved for use in dogs) ...

*Antihypotensive agent

Reboxetine Venlafaxine Positive inotropic agents Cardiac glycosides Strophantin K Corglycon Digoxin Others Amrinone Milrinone " ...

*List of MeSH codes (D03)

... amrinone MeSH D03.383.725.050.085.543 --- milrinone MeSH D03.383.725.050.440 --- methapyrilene MeSH D03.383.725.050.610 --- ...

*Schedule H

Amrinone Lactate Analgin Androgenic, Anabolic, Oestrogenic and Progestational Substances Antibiotics Aprotinin Organic Compound ...

*ATC code C01

... combinations C01CE01 Amrinone C01CE02 Milrinone C01CE03 Enoximone C01CE04 Bucladesine QC01CE90 Pimobendane C01CX06 ...

*List of MeSH codes (D02)

... amrinone MeSH D02.092.080.085.543 --- milrinone MeSH D02.092.146.100 --- aminophenols MeSH D02.092.146.100.700 --- phenetidine ...

*List of drugs: Am

Amrinone amrinone (INN) amrubicin (INN) amsacrine (INN) amsilarotene (USAN) amtolmetin guacil (INN) amustaline dihydrochloride ...

*Inotrope

Angiotensin II Eicosanoids Prostaglandins Phosphodiesterase inhibitors Enoximone Milrinone Amrinone Theophylline Glucagon ...

*Peter Wilmshurst

... approached The Guardian newspaper with a substantial dossier detailing alleged misconduct in the development of Amrinone, a ...
Amrinone is a nonglycosidic, non-catecholamine-dependent, inotropic vasodilator agent that has recently been made available for intravenous use in patients with severe heart failure. Because other agents, such as dopamine, dobutamine, and nitroprusside, are available and have actions similar to those of amrinone in patients with heart failure, the usefulness of this newer agent must be put in perspective.. Amrinone is advertised as a "major advance" in inotropic therapy because of its alleged advantages of more sustained action than dopamine or dobutamine and reduction of myocardial oxygen demand. The evidence for these claims and their importance appears minimal. Recent reports indicate ...
In a prospective trial, the immediate and long-term haematological effects of amrinone were studied in sixteen patients with refractory cardiac failure. The platelet count was significantly and variably reduced in all patients and the reduction was related to log plasma amrinone concentration. Platelet survival was significantly reduced in those cases studied. No evidence of disseminated intravascular coagulation or intravascular platelet deposition was observed and the reduced platelet survival was not considered to be the result of an immunological process. Evidence of a marrow response to the reduced platelet count and survival was seen. Although no haemorrhagic symptoms were observed in the patients, the haematological side-effects were considered to be of such severity as to limit the use of this drug in clinical practice ...
Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). The positive inotropic effect of amrinone is mediated by the selective enhancement of high gain CICR which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways. Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. There is a long-standing controversy regarding whether the drug actually increases cardiac contractility in diseased myocardium (and therefore whether it is of any clinical use). The issue has been reviewed extensively by Dr Peter Wilmshurst, one ...
MedicScientist is provided for information purposes only and should not be used as a substitute for evaluation and treatment by a physician. Terms of Use. Poward ByAceDesigno. ...
Our study demonstrates that drugs that stimulate the AC/PKA pathway can increase cardiac contractions initiated by CICR and/or the VSRM. Forskolin or IBMX caused a nonselective increase in contractions and inward currents. In contrast, amrinone, which selectively inhibits PDE III, increased the amplitude of VSRM contractions with virtually no effect on CICR or ICa-L. All three agents increased the fraction of SR Ca2+ stores released by depolarizations typically used to activate the VSRM. However, none of these drugs increased the fraction of Ca2+released from the SR by CICR. These observations demonstrate that drugs that stimulate the AC/PKA pathway can modulate the VSRM, and that the VSRM can be modulated independently of effects on CICR and ICa-L.. The AC/PKA pathway phosphorylates several protein targets important in excitation-contraction coupling. These targets include L-type Ca2+ channels (McDonald et al., 1994), ryanodine receptors (Takasago et al., 1989), phospholamban (Tada et al., ...
2) You have recieved a new admission from the E.R. The patient has class IV CHF and the doctor has ordered a loading dose of Inocor (amrinone lactate). The loading dose is to be administered over 3 minutes. Pharmacy has brought the loading dose as a 50 mL IVPB. At what rate should the IVPB be infused? Answer is 1000 mL/hour.. Using the calculator, select time to equal minutes. Next, enter 3 as the value for time (3 minutes). Enter 50 as the volume to be infused. Click the solve button which calculates the result as 1000 mL/hour. See the example below. ...
Integrated lens antennas (ILAs) are essentially high-gain (sub)millimeter-wave radiating structures. They often have a moderate (or even poor) aperture eff
In mice, injected fragments of a naturally occurring protein boost memory in young and old animals and improve cognition and mobility in a model of neurodegenerative disease. 0 Comments. ...
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Introduction. Positive inotropic agents increase the force of ventricular contraction mediated through a suppression of phosphodiesterase activity (amrinone, milrinone, pimobendan, levosimendan), act as sympathicomimetic (dopamine, dobutamine) or increase the calcium sensitivity of the contractile proteins (pimobendan, levosimendan). The phosphodiesterase inhibitors also have arterial vasodilating properties to a varying degree. Positive inotropes are currently well established in treatment of acute heart failure precipitated by a hypocontractile failing heart both in dogs and in people. For instance, intravenous infusion of dobutamine has been used for years to manage dogs with acute heart failure caused by dilated cardiomyopathy (DCM). In people, intravenous infusion of levosimendan is frequently used in severe congestive heart failure. Mainly because of cost, the latter therapy is usually not used in dogs. Regardless of which type of intravenous infusion administered, there has been a problem ...
Forty-two molecules, thirty-eight milrinone analogues, two lead compounds, amrinone and milrinone, and two commercial products have been studied using chemometrical techniques applied to thirty theoretical descriptors and two biological activities (each one at three different concentrations). PLS Regression was applied both in the usual form PLS-I, with one response variable, and as PLS-2, with the contemporary study of more activities in the block of response variables. Regression models (both with the original activities and with log and arctan transforms) were refined by progressive elimination of conformers and of non-relevant predictors, one-at-a-time, on the basis of the relevance in the regression equation. Different sorts of model refinement gave origin to four chemometrical strategies. Special attention was deserved to the development of validation procedures for the regression analysis, in order to evaluate the true predictive ability of the refined models. The predictive optimization ...
Pirbuterol (trade name Maxair) is a short-acting β2 adrenoreceptor agonist with bronchodilating action used in the treatment of asthma, available (as pirbuterol acetate) as a breath-activated metered-dose inhaler (Maxair Autohaler). Pirbuterol is used in asthma for reversal of acute bronchospasm, and also as a maintenance medication to prevent future attacks. It should be used in patients 12 years of age and older with or without concurrent theophylline and/or inhaled corticosteroid. After inhalation of doses up to 800 μg (twice the maximum recommended dose) systemic blood levels of pirbuterol are below the limit of assay sensitivity (2-5 ng/ml). A mean of 51% of the dose is recovered in urine as pirbuterol plus its sulfate conjugate following administration by aerosol. Pirbuterol is not metabolized by catechol-O-methyltransferase. The plasma half-life measured after oral administration is about two hours. "Maxair Autohaler (pirbuterol acetate inhalation aerosol) For Oral Inhalation Only. U.S. ...
Defined as RVH (and subsequent ventricular dysfunction) secondary to chronic pulmonary hypertension. The key to management in these patients is to avoid increasing PVR (precipitants include hypoxemia, hypercarbia, acidosis, nitrous oxide [Hilgenberg JC et al. Anesth Analg 59: 323, 1980]). In severe cases, beta-agonists may be required to overcome PVH, but with the concomitant risk of myocardial ischemia. Phosphodiesterase inhibitors (amrinone, milrinone) may be needed as they can both improve ventricular function and induce vasodilation (thus reducing afterload).. ...
An erbium-doped fiber amplifier with a high small-signal gain of 42 dB at the gain peak of 1536.4 nm, a pumping efficiency of 1.6 dB/mW, and an output satu
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells,
WebMD provides common contraindications for Pirbuterol Inhalation. Find out what health conditions may be a health risk when taken with Pirbuterol Inhalation
Web: ewh.ieee.org/r6/scv/emc Choosing the right antenna for radiated immunity measurements can be quite challenging, especially above 1 GHz.? On the one hand, a high-gain antenna is desired to reduce the amplifier power needed.? On the other hand, the 3-dB-beamwidth needs to be taken into account to maximize the illuminated area.? This is especially true for measurements according to IEC61000-4-3, MIL-STD 461 or full-vehicle testing according to MIL-STD 464 ...
Learn about Maxair (Pirbuterol) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
We report on investigation the potential of a 7 wt% (8.35 × 1020 Tm3+/cm3) doped silicate fibers for high-gain fiber amplifiers. Such a high ion concentration significantly reduces the required fiber length of high-power 2 μm fiber laser systems and allows the high-repetition rate operation in 2 μm mode-locked fiber lasers. To evaluate the feasibility of extracting high gain-per-unit-length from this gain medium, we measure several key material properties of the silicate fiber, including the absorption/emission cross-sections, upper-state lifetime, fiber background loss, and photodarkening resistance. We show through numerical simulations that a signal gain-per-unit-length of 3.78 dB/cm at 1950 nm can be achieved in a watt-level core-pumped Tm3+-doped silicate fiber amplifier. In addition, an 18-dB 2013-nm amplifier is demonstrated in a 50-cm 7 wt% Tm3+-doped double-clad silicate fiber. Finally, we experimentally confirm that the reported silicate host exhibits no observable photodarkening.
Bupivacaine-induced myocardial depression and pulmonary edema: a case report.: Central nervous system and cardiovascular toxicity are well-known side effects of
Sigma-Aldrich offers abstracts and full-text articles by [Rongrong Li, He Ma, Xiaojin Zhang, Chuanfu Li, Jingwei Xiong, Ting Lu, Yu Mao, Juncheng Dai, Li Liu, Zhengnian Ding].
J.B. Michael, M.R. Edwards, A. Dogariu and R.B. Miles, "Femtosecond laser electronic excitation tagging for quantitative velocimetry imaging in air," Applied Optics 50, 5158 (2011). doi:10.1364/AO.50.005158 Dogariu, J.B. Michael, M.O. Scully and R.B. Miles, "High-gain backward lasing in air," Science 331, 442 (2011). doi:10.1126/science. ...
Deliberant 802.11 an MiMo 18 dBi dual pol panel(DLB-APC-5M-18) The APC 5M-18 delivers the highest performance and stability available in the 5 GHz CPE class. This product combines a robust IP-67 compliant enclosure with a highly advanced 802.11n radio core containing MIMO 2x2 technology along with an integrated high-gain dual polarization directional antenna. The device is powered by a reliable, advanced, and feature-rich operating system, allowing the creation of very high throughput and stable wireless networks quickly, safely, and effectively. In addition, the APC 5M-18 supports access point operating mode which extends application scenarios and makes the APC 5M-18 suited for both point to point and point to multipoint networks. The robust software engine allows the APC 5M-18 to work as bridge or as a router, provides a user-friendly Adobe Flex - based GUI with instant changes, includes useful installation tools (Site survey, Antenna alignment, Delayed reboot, Spectrum analyzer), and also is
Trichloroethanes: Chlorinated ethanes which are used extensively as industrial solvents. They have been utilized in numerous home-use products including spot remover preparations and inhalant decongestant sprays. These compounds cause central nervous system and cardiovascular depression and are hepatotoxic. Include 1,1,1- and 1,1,2-isomers.
Bipyridine glycoluril (BPG), a urea-fused bipyridine tecton, forms a square-pyramidal secondary building unit with copper(ii) which further self-assembles to give a porous hydrogen-bonded complex. This complex displays a high proton conductivity of 4.45 × 10−3 S cm−1 at 90 °C and 95% relative humidity (RH).
We report on the photoluminescence (PL) properties of heavily Eu2O3 doped Y2O3-Al2O3-B2O3 glasses as a high-gain red-emitting material for photoconversion. A UV-to-red conversion efficiency of up to 60% is achieved in this material. Concentration quenching is related to the formation of -{Eu-O-Me-O-Eu}- (Me
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The complex cation ligand [Ru(pytpy)2]2+ (pytpy = 4′-(4-pyridyl)-2,2′∶6′,2″-terpyridine) is an expanded 4,4′-bipyridine; we describe the first example of a coordination polymer in which [Ru(pytpy)2]2+ plays the role of a bridging bidentate ligand. RACI100: Celebrating Australian Chemistry
SF 349, an analogue of milrinone, was being developed at a number of universities in Italy as a cardiotonic agent. It was in preclinical investigation and
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2,2′-Bipyridine (2,2′-bipy) is a chelating ligand that forms complexes with most transition metal ions that are of broad academic interest. Many of these complexes have distinctive optical properties, and some are of interest for analysis. Its complexes are used in studies of electron and energy transfer, supramolecular and materials chemistry, and catalysis.. 2,2′-Bipyridine is used in the manufacture of diquat.. ...
A numerical model for erbium-doped waveguide amplifiers (EDWAs) containing bent waveguides was developed. The model uses rate-propagation equations and takes into account bend-induced losses in the waveguide with a varying radius of curvature. It is applied to the design of tightly packed erbium-doped waveguide amplifiers under two constraints: minimization of the area required to obtain a predetermined gain and maximization of the gain available from a given area. Numerical calculations based on realistic waveguide parameters demonstrate the possibility of fabricating high-gain, small-size EDWAs. Simple design rules, based on geometric formulas and consideration of bend losses, are given and compared with the results of numerical calculations.. © 2005 Optical Society of America. Full Article , PDF Article ...
50525-27-4 - UUSPGQXHSZVVNL-UHFFFAOYSA-L - Tris(bipyridine)ruthenium(II) chloride hexahydrate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
... is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries. Milrinone is used as a short-term treatment for life-threatening heart failure. Milrinone may also be used for...
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We report on the design and fabrication of ZnO-based integrated inverters consisting of normally-on metal-semiconductor field-effect transistors and AgxO Schottky diodes as level shifters. The inverters show high gain values up to 197 at 3 V operating voltage and low uncertainty levels in the range of 0.13 V. The influence of the level shifter and the channel material/thickness on the performance of the inverters has been investigated. Using Zn0.997Mg0.003O for the channel thin film leads to high reproducibility (90%) of the devices. A logic NOR-gate has been implemented showing the possibility to fabricate a complete logic ...
milrinone 78415-72-2 MSDS report, milrinone MSDS safety technical specifications search, milrinone safety information specifications ect.
Sometime tomorrow, the plan is to discontinue Pattys milrinone transfusion, at least temporarily. Im nervous about the effect on Patty, as I was when the dose was halved. With the reduced dose, she seems to have less energy than when she was receiving the full amount. Well keep you posted about what happens. On the plus side, she wont have to lug around the big bag with the pump, so shell at least enjoy a modicum of freedom ...
Vetmedin (Pimobendan) is in a class of heart treatments named inodilators used in the management of certain types of congestive heart failure in dogs.
Looking for online definition of Neurosurgical procedures in the Medical Dictionary? Neurosurgical procedures explanation free. What is Neurosurgical procedures? Meaning of Neurosurgical procedures medical term. What does Neurosurgical procedures mean?
Alcoholic depression of left ventricular function was produced in normal hamsters by the administration of increasing concentrations of alcohol in drinking water (up to 50%) for 6 months. The result was assessed by phosphorus-31 nuclear magnetic resonance of isolated perfused hearts and high-pressure liquid chromatography of freeze-clamped tissues. Hemodynamic data and myocardial oxygen consumption were also monitored. Alcoholic hamsters had significantly higher inorganic phosphate and lower ATP levels, while maintaining normal intracellular pH, phosphocreatine, and creatine. Although coronary flow and oxygen consumption were maintained at normal levels, hamsters ingesting 50% ethanol had significantly lower left ventricular developed pressure and dP/dt. Treatment with verapamil during long-term ethanol consumption prevented the development of these metabolic and functional abnormalities. It is hypothesized that alcohol produces membrane abnormalities leading to adverse ion flux, and that these ...
Cardiotonic Agents: Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology, metabolism, cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in todays scientific literature and serves as an international forum for the scientific community worldwide to translate pioneering
Key non-adrenergic cardiovascular drugs include vasopressin (and its analogues, teripressin and ornipressin), phosphodiesterase III inhibitors such as milrinone, and calcium sensitisers such as levosimendan.. ...
[150 Pages Report] Check for Discount on 2016 Global and Chinese Bipyridine (CAS 366-18-7) Industry Market Research Report report by Prof Research. The Global and Chinese Bipyridine Industry, 2011-2021 Market Research...
What if you combine the ruthless sustain of a silver box Big Muff with the harmonic signature of a Tone Bender MkII and the unrivaled touch dynamics of a germanium Fuzz Face? Would you get the ultimate vintage Fuzz pedal? At Supro USA, they think so. The Supro Fuzz takes this best-of-all-worlds approach to old-school fuzz using an N.O.S. Germanium transistor in the first stage, followed by secondary, silicon-based gain and a dash of our special sauce to create a low-noise, high-gain fuzz box that will leave you deaf and breathless.Whether youre looking for a touch-sensitive, vintage 60s flavor or a full-on wall of modern sonic destruction, the Supro Fuzz delivers the goods while keeping your noise floor amazingly low. The Supro Fuzz pedal sports a simple control layout with Volume, Gain, Treble and Bass knobs. The independent EQ found on this pedal is drawn from the award-winning tone stack found in our flagship tube amplifiers, offering a huge range of adjustability without the frustrating
This invention provides an electrically plastic device in which an electron conjugated polymeric semiconductor layer containing a mobile dopant is formed across a pair of electrodes and at least one gate electrode is provided between said pair of electrodes with an insulating layer or a high-resistance layer interposed along said electron conjugated polymeric semiconductor layer, so that the dopant distribution in said electron conjugate polymeric semiconductor layer is controlled through said gate electrode, thereby controlling the electrical conductivity of said electron conjugated polymeric semiconductor layer. The device utilizes the substantially large variation in the electrical conductivity of an electrically conductive polymer depending on its dopant concentration, thus allowing a high-gain neurochip to be constructed. The control method of the electrically plastic device in accordance with this invention is carried out in such a way that a positive or negative pulse voltage is applied to the
General concepts regarding the role of the sympathetic nervous system in the pathogenesis of heart failure (and as a site for therapeutic intervention) have undergone a remarkable transition in the last few years. When β-adrenergic receptor (β-AR) blockers were first introduced into clinical practice more than 30 years ago, they were viewed as contraindicated in heart failure. Conventional wisdom held that patients with impaired ventricular function rely on increased sympathetic drive as a mechanism to maintain mechanical performance and would clinically deteriorate if exposed to the negative inotropic actions of β-AR antagonists. However, clinical practice demonstrated that although positive inotropic agents and vasodilators (agents that directly or indirectly activate neurohormonal pathways) induce short-term hemodynamic improvement, this is offset by long-term adverse effects to accelerate the natural history of heart failure. In contrast, β-AR-blocking drugs prevent or reverse many of ...
Decrease cardiovascular depression associated with general anesthesia ... After one minute intubation occurs without laryngospasm. Local Infiltration ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 25b3d6-ZDc1Z
your post is particularly ironic to me, because i discovered that fact to my great grief last week. i had a 20 yr old girl, who had a minor argument with her mother and had taken rat poison(which most often has al. phosphide).she presented about twelve hours before the end of my shift, and when i was leaving after my shift, she was looking forward to go back to work, worrying about her boss and all that. no medical complications at all, save for an improving met. acidosis. i told her mother that she was ok and would be better by the next day. when i returned 24 hrs later, she was being resuscitated after having developed pulmonary edema following rapidly developing renal failure, with the met. acidosis leading to cardiac depression and ultimately death, all in a matter of six hours. declaring her was the most difficult thing for me to do, even though i spent practically the whole of the past five years in an ICU and was no stranger to traumatic deaths. ...
Cocaine overdoses can apparently be reversed by a drug called dexmedetomidine. They did a study in 2007 that showed the drug can revert the effects of small doses of cocaine, both in the nervous system and in the cardiovascular system. Apparently they have yet to determine whether it works on larger doses, but it seems likely that it should (im saying that, the researchers didnt say that). A good thing about dexmedetomidine is that it doesnt cause respiratory depression. I assume that that makes it a better candidate for treating cocaine overdoses (than other depressants) because when the coke has been mixed with depressants, it wont cause the person to die of respiratory depression (although cardiovascular depression might still happen i guess. any doctors out there or anyone who knows, id be happy to hear if you think that makes sense). Anyway, if all this makes sense, this drug should also be available by prescription to cocaine users. I dont know about over the counter (at least not ...
Milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy ...
Information on the following variables was collected: BW, GA, sex, mode of delivery, Apgar score (at 1 and 5 minutes), age at the moment of transport (days of life) and the presence of an antenatal diagnosis (defined as the presence of a malformation or congenital disease during pregnancy). For every referral, the following data were also recorded: transport distance in kilometers according to three ordinal categories (,60 km, 60-300 km, ,300 km), place of referral, type of disease (according to the main organ or system involved), severity of the infant´s condition according to the SNAP II risk score, use of respiratory assistance and/or administration of inotropic drugs during transport, professionals in charge of the transport. Selection of these variables was related to the assumption that more immature or severely compromised children, and/or longer distance (with longer duration of transport) could be predisposing factors for deterioration. Additional data recorded were: the use of an ...
Information on the following variables was collected: BW, GA, sex, mode of delivery, Apgar score (at 1 and 5 minutes), age at the moment of transport (days of life) and the presence of an antenatal diagnosis (defined as the presence of a malformation or congenital disease during pregnancy). For every referral, the following data were also recorded: transport distance in kilometers according to three ordinal categories (,60 km, 60-300 km, ,300 km), place of referral, type of disease (according to the main organ or system involved), severity of the infant´s condition according to the SNAP II risk score, use of respiratory assistance and/or administration of inotropic drugs during transport, professionals in charge of the transport. Selection of these variables was related to the assumption that more immature or severely compromised children, and/or longer distance (with longer duration of transport) could be predisposing factors for deterioration. Additional data recorded were: the use of an ...
A new study finds that patients who undergo a neurosurgical procedure with surgical start times between 9 pm and 7 am are at an increased risk of developing complications compared to patients with a surgical start time earlier in the day. ...
Get details about the EPIC (Evaluation of Pimobendan In dogs with Cardiomegaly) Study, the largest veterinary cardiology study in history.
Experiments were performed on littermate control (Kv1.1+/+), heterozygous (Kv1.1+/-), and null (Kv1.1-/-) mice. Breeding pairs were purchased from The Jackson Laboratory (Bar Harbor, ME), and offspring were genotyped as previously described (Zhou et al., 1998). All of the experimental protocols were in compliance with the Case Western Reserve University Institutional Animal Care and Use Committee guidelines.. Measurement of respiratory variables. In unanesthetized animals, respiration was monitored by whole-body plethysmography as previously described (Kline et al., 2002a). Briefly, animals were placed in a 600 ml Lucite chamber that contained an inlet port for gas administration and an outlet port for airflow and gas sampling. The chamber was connected to a high-gain differential pressure transducer (Valydine MP45; Validyne, North Ridge, CA). As the animal breathed, changes in pressure were converted to signals representing tidal volume (VT), which were amplified (BMA 830; CWE, Ardmore, PA), ...
Hospitalizations for acute heart failure are associated with high mortality and readmission rates. Ten to 20% of the patients have signs of low cardiac output and fluid overload. The administration of inotropic agents to correct these hemodynamic abnormalities may be indicated in these patients. However, the risk to benefit ratio of inotropic agents is high and an increase of untoward effects and mortality has been suggested by many retrospective analyses and meta-analyses. Limitations of inotropic therapy seem mainly related to their mechanisms of action based, in the case of the traditional agents, on an increase in intracellular cyclic AMP and calcium concentrations. Concomitant peripheral vasodilation, such as in the case of the novel agent levosimendan is another important limitation, above when patients are hypotensive and/or treated with vasodilators and high doses of diuretics. Myosin activators, histaroxime, sarcoplasmic reticulum ATPase activators and metabolic agents seem promising as active
DuraSeal™ is a new, synthetic gel designed to seal the sutured dura following cranial neurosurgical procedures. It has been approved by the FDA last
Hi all, its ages since I was last here. Bertie is now six and a half, my best friend. Sadly, he has developed heart disease and some changes on his lungs too. He is now on Pimobendan and two diuretics. Vet has said he reckons sbout 18 months to 2 year left :-( Im so upset and am going to make the most of him. Not sure what else to say now, will be reading any threads on this sort of thing to see if I can learn anything.
This artists rendering shows NASAs Voyager spacecraft. On the boom to the right, the Cosmic Ray Science instrument, Low Energy Charged Particle detector, the Infrared Spectrometer and Radiometer, Ultraviolet Spectrometer, Photopolarimeter and Wide and Narrow Angle Cameras are visible. The bright gray square is an optical calibration plate for the instruments. The Golden Record, containing images and sounds from Earth, is the yellow circle on the main spacecraft body. The dish is the spacecrafts high-gain antenna for communications with Earth. The magnetometer boom stretches out to the upper left. The radio isotope thermoelectric generators, Voyagers power source, are visible to the lower left.. The two long thin rods extending out to the left are antennas used by the Plasma Wave instrument. The Planetary Radio instrument also used these antennas when it was turned on.. The two Voyager spacecraft are identical. Voyager 2 was launched on Aug. 20, 1977. Voyager 1 was launched on Sept. 5, ...
Drug: Inhaled, nebulized, Milrinone. 1 mg/ml milrinone (dissolved in dextrose) and diluted in 0.9% normal saline in a 1:1 ratio to final drug concentration of 0.5mg/ml will be delivered via an IV pump at a fixed dose of 12 ml/hour which will run into a vibrating mesh nebulizer reservoir, connected to the mechanical ventilator circuit. Inhaled milrinone will begin at time of resumption of mechanical ventilation when initiating wean from cardiopulmonary bypass after LVAD implantation in the operating room, and run continuously for a total maximum duration of 24 hours OR until the patient is extubated whichever occurs first. Plasma milrinone levels will be assessed to determine if systemic milrinone absorption occurs after prolonged milrinone inhalation. ...
1. The elevated beta-receptor responsiveness to adrenergic stimuli makes subjects with the primary hyperkinetic cardiac syndrome ideal for studying the electrical and dynamic responses of the heart to sympathetic activation.. 2. In twelve men presenting with the syndrome, the effects of mental arithmetic and painful (cold) stress on the cardiac inotropic state were tested and correlated with the concomitant electrocardiographic changes.. 3. Arithmetic and cold evoked responses opposite and divergent from the base-line state: The former induced vasodilatation, enhancement of cardiac rate, output, contractility and deep T wave inversion; the latter caused vasoconstriction, cardiac depression and full restoration of repolarization.. 4. The sympathetic outflow elicited by stress is not generalized, but selectively directed to different circulatory levels in relation to the stimulus at work; cardiac sympathetic stimulation or inhibition has opposite effects on the repolarization phase.. ...
Search Indian Milrinone Lactate Injection Manufacturers and Suppliers Details - Contact to Milrinone Lactate Injection Exporters in India, Milrinone Lactate Injection Wholesalers, Milrinone Lactate Injection Distributors and Traders from India.
Milrinone Lactate Injection is provided as a sterile, clear, colourless to pale yellow solution. For ease of administration Milrinone Lactate Injection may be diluted with suitable diluents such as Normal or Half Normal Saline Injection or sterile 5% Dextrose Injection, or may be used undiluted if suitable equipment is available.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
milrinone | C12H9N3O | CID 4197 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
How Digoxin (lanoxin) works: INCREASES CONTRACTILITY OF THE HEART: TECH Term, it creates a POSITIVE INOTROPIC EFFECT. The Positive INOTROPIC Effect occur

Amrinone - WikipediaAmrinone - Wikipedia

Both inotropic and lusitropic effects are the reason why amrinone is used to treat heart failure. Amrinone decreases the ... There is a net decrease in myocardial wall tension, and O2 consumption when using amrinone. Amrinone also has beneficial ... Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR ... Amrinone should only be diluted with normal saline or 1/2 normal saline; no dextrose solutions should be used. Furosemide ...
more infohttps://en.wikipedia.org/wiki/Amrinone

Intravenous Amrinone: An Advance or a Wrong Step? | Annals of Internal Medicine | American College of PhysiciansIntravenous Amrinone: An Advance or a Wrong Step? | Annals of Internal Medicine | American College of Physicians

Amrinone is advertised as a "major advance" in inotropic therapy because of its alleged advantages of more sustained action ... Intravenous Amrinone: An Advance or a Wrong Step?. Ann Intern Med. 1985;102:399-400. doi: 10.7326/0003-4819-102-3-399 ... Amrinone is a nonglycosidic, non-catecholamine-dependent, inotropic vasodilator agent that has recently been made available for ... Intravenous Amrinone: An Advance or a Wrong Step? JOSEPH A. FRANCIOSA, M.D. ...
more infohttp://annals.org/aim/article-abstract/699502/intravenous-amrinone-advance-wrong-step

Use of milrinone in cardiac surgical patients | SpringerLinkUse of milrinone in cardiac surgical patients | SpringerLink

Hess W. Effects of amrinone on the right side of the heart.J Cardiothorac Vasc Anesth 1989;3(Suppl 2):38-44.Google Scholar ... Amrinone versus conventional therapy in patients awaiting cardiac transplantation.Ann Thorac Surg 1989;48:665-669.Google ... Effect of amrinone on right ventricular function: Predominance of afterload reduction.Circulation 1986;74:359-366.Google ... Additive effects of dobutamine and amrinone on myocardial contractility and ventricular performance in patients with severe ...
more infohttps://link.springer.com/article/10.1007/BF00877820

Patent US6037346 - Local administration of phosphodiesterase inhibitors for the treatment of ... - Google PatentsPatent US6037346 - Local administration of phosphodiesterase inhibitors for the treatment of ... - Google Patents

Various compounds are known as inhibitors of phosphodiesterases are known, including vinpocetine, milrinone, amrinone, ...
more infohttp://www.google.com.au/patents/US6037346

Milrinone Lactate Injection - Pharmaceutical Information, Clinical Trials, Detailed Pharmacology, ToxicologyMilrinone Lactate Injection - Pharmaceutical Information, Clinical Trials, Detailed Pharmacology, Toxicology

Compared with the in vitro inotropic activity of amrinone, milrinone was approximately 30 times more potent. ... In the isolated rabbit renal artery preparation milrinone and amrinone were approximately equipotent against both potassium and ... norepinephrine-induced contractions, with nifedipine being considerably more potent than either milrinone or amrinone in this ...
more infohttp://www.imedez.com/drugs/milrinone-lactate-injection/Scientific-Information.html

Pharmacology definition - Phosphodiesterase Inhibitor  - Medical ZonePharmacology definition - Phosphodiesterase Inhibitor - Medical Zone

Phosphodiesterase inhibitor such as amrinone or milrinone will inhibit and block the action of phosphodiesterase/ ...
more infohttp://www.medicalzone.net/pharmacology-definition---phosphodiesterase-inhibitor.html

Amrinone - DrugBankAmrinone - DrugBank

Amrinone (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart ... Amrinone. Accession Number. DB01427. Type. Small Molecule. Groups. Approved. Description. Amrinone (or inamrinone) is a type 3 ... Amrinone. ATC Codes. C01CE01 - Amrinone*C01CE - Phosphodiesterase inhibitors. *C01C - CARDIAC STIMULANTS EXCL. CARDIAC ... Amrinone lactate. I229274Y5B. 75898-90-7. DOSIONJFGDSKCQ-UHFFFAOYSA-N. Prescription Products. Name. Dosage. Strength. Route. ...
more infohttps://www.drugbank.ca/drugs/DB01427

Amrinone lactate - Biology-Online DictionaryAmrinone lactate - Biology-Online Dictionary

Amrinone lactate 5-Amino-(3,4-bipyridin)-6(1H)-one;an inotropic agent with vasodilator activity, used in management of ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Amrinone_lactate&oldid=38748" ...
more infohttps://www.biology-online.org/dictionary/Amrinone_lactate

Tachyphylaxis with Amrinone Therapy: Association with Sequestration and Down-Regulation of Lymphocyte Beta-Adrenergic Receptors...Tachyphylaxis with Amrinone Therapy: Association with Sequestration and Down-Regulation of Lymphocyte Beta-Adrenergic Receptors...

Tachyphylaxis with Amrinone Therapy: Association with Sequestration and Down-Regulation of Lymphocyte Beta-Adrenergic Receptors ... Tachyphylaxis with Amrinone Therapy: Association with Sequestration and Down-Regulation of Lymphocyte Beta-Adrenergic Receptors ... Interventions: A bolus of intravenous amrinone followed by a continuous infusion at 10 µg/kg · min for 72 hours. ... Study Objective: To determine whether intravenous therapy with amrinone changes number, location or function of the β- ...
more infohttps://annals.org/aim/article-abstract/702887/tachyphylaxis-amrinone-therapy-association-sequestration-down-regulation-lymphocyte-beta-adrenergic

High-dose Amrinone Is Required to Accelerate Rewarming from Deliberate Mild Intraoperative Hypothermia for Neurosurgical...High-dose Amrinone Is Required to Accelerate Rewarming from Deliberate Mild Intraoperative Hypothermia for Neurosurgical...

AMR 15 (open circle) = a group of patients who re-ceived 15 μg · kg−1· min−1amrinone with a 1.0-mg/kg loading dose of amrinone ... AMR 15 (open circle) = a group of patients who re-ceived 15 μg · kg−1· min−1amrinone with a 1.0-mg/kg loading dose of amrinone ... AMR 15 (open circle) = a group of patients who re-ceived 15 μg · kg−1· min−1amrinone with a 1.0-mg/kg loading dose of amrinone ... AMR 15 (open circle) = a group of patients who re-ceived 15 μg · kg−1· min−1amrinone with a 1.0-mg/kg loading dose of amrinone ...
more infohttps://anesthesiology.pubs.asahq.org/article.aspx?articleid=1944010

Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane Anesthesia in Dogs | Anesthesiology | ASA...Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane Anesthesia in Dogs | Anesthesiology | ASA...

Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane Anesthesia in Dogs. Anesthesiology 6 1987, Vol. ... Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane Anesthesia in Dogs ... Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane Anesthesia in Dogs ... Virve H. M. Makela, Patricia A. Kapur; Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane ...
more infohttps://anesthesiology.pubs.asahq.org/article.aspx?articleid=1954101

The effects of amrinone on platelet count, survival and function in patients with congestive cardiac failure.The effects of amrinone on platelet count, survival and function in patients with congestive cardiac failure.

... ... The platelet count was significantly and variably reduced in all patients and the reduction was related to log plasma amrinone ... In a prospective trial, the immediate and long-term haematological effects of amrinone were studied in sixteen patients with ...
more infohttp://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/28477

Part 6: Advanced Cardiovascular Life Support | CirculationPart 6: Advanced Cardiovascular Life Support | Circulation

Amrinone and Milrinone. Amrinone and milrinone are phosphodiesterase III inhibitors that have inotropic and vasodilatory ... Amrinone is administered as a dose of 0.75 mg/kg given initially over 2 to 3 minutes, followed by an infusion of 5 to 15 μg/kg ... Amrinone has a more significant effect on preload than catecholamines, and the hemodynamic effects are similar to those of ... Like amrinone, milrinone has a relatively long plasma half-life, which makes dose titration more difficult. Milrinone may also ...
more infohttp://circ.ahajournals.org/content/102/suppl_1/I-129.full

Phosphodiesterase (PDE) InhibitorsPhosphodiesterase (PDE) Inhibitors

BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVisions products are currently being sold in more than 60 countries worldwide.
more infohttps://www.biovision.com/products/biochemicals/enzyme-inhibitors/phosphodiesterase-pde-inhibitors.html

February 1987 - Volume 9 - Issue 2 : Journal of Cardiovascular PharmacologyFebruary 1987 - Volume 9 - Issue 2 : Journal of Cardiovascular Pharmacology

The Cardiotonic Agent Amrinone Does Not Increase Anatomic Infarct Size. Campbell, Colin A.; Mehta, Prabodh M.; Wynne, Joshua; ...
more infohttps://journals.lww.com/cardiovascularpharm/toc/1987/02000

Drugs for Heart Failure  Flashcards by sweet sweetmintlove | BrainscapeDrugs for Heart Failure Flashcards by sweet sweetmintlove | Brainscape

Inamrinone (formerly Amrinone). •Milrinone 89 •Short-term IV milrinone: not associated with increased risk of mortality; ...
more infohttps://www.brainscape.com/flashcards/drugs-for-heart-failure-1543971/packs/2969303

September 2018 - Page 4 of 5 - All about medicineSeptember 2018 - Page 4 of 5 - All about medicine

Antidepressants With Amrinone Safe: Study. Sep 2, 2018. RosaNutrition‎. Esika hydracolor 2 in 1 spf 25 (pimienta caliente ...
more infohttp://rosesturn.com/2018/09/page/4

Patente US6987129 - Compounds and methods for the treatment of urogenital disorders - Google PatentesPatente US6987129 - Compounds and methods for the treatment of urogenital disorders - Google Patentes

The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial cystitis, nonspecific urethriris (i.e., nonspecific pain and/or burning of the urinary tract) and sexual dysfunctions, such as, for example, female sexual arousal disorders and female sexual orgasmic disorders, using a variety of compounds, including, but not limited to, NO donors, calcium channel blockers, cholinergic modulators, α-adrenergic receptor antagonists, β-adrenergic receptor agonists, phosphodiesterase inhibitors, cAMP-dependent protein kinase activators (e.g., cAMP mimetics), superoxide scavengers, potassium channel activators, estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, antidiarrheal agents, HMG-CoA reductase inhibitors, smooth muscle relaxants, adenosine receptor modulators, adenylyl cyclase activators, endothelin receptor antagonists,
more infohttp://www.google.es/patents/US6987129

Schedule H - WikipediaSchedule H - Wikipedia

AMRINONE LACTATE 30. ANALGIN 31. ANDROGENIC ANABOLIC, OESTROGENIC & PROGESTATIONAL SUBSTANCES 32. ANTIBIOTICS ...
more infohttps://en.wikipedia.org/wiki/Schedule_H

Cardiology - Drugs| MedindiaCardiology - Drugs| Medindia

Amrinone. Antiarrhythmic Agent Dobutamine Antiarrhythmic Agent Digoxin Antiarrhythmic Agent Dopamine Antiarrhythmic Agent ...
more infohttp://www.medindia.net/drugs/speciality/cardiology.htm

UniProt: P01375UniProt: P01375

DR DrugBank; DB01427; Amrinone. DR DrugBank; DB05676; Apremilast. DR DrugBank; DB05066; AV411. DR DrugBank; DB08904; ...
more infohttp://www.genome.jp/dbget-bin/www_bget?uniprot:P01375

Cardiac ArrestCardiac Arrest

Amrinone. Amrinone: PDE inhibitor that has ionotropic and vasodilatory actions. Despite its dual activity is has not been ... Amrinone is contraindicated in hypertrophic cardiomyopathy and possibly if platelets , 50,000. Dopamine. Dopamine: at 0.5 - 3.0 ... Amrinone should not be infused with furosemide because the two precipitate. Thrombocytopenia occurs in 2 - 3% of patients. ...
more infohttp://www.openanesthesia.org/cardiac_arrest/

Nitroprusside - DrugBankNitroprusside - DrugBank

Amrinone. Amrinone may increase the hypotensive activities of Nitroprusside.. Approved. Amyl Nitrite. The risk or severity of ...
more infohttps://www.drugbank.ca/drugs/DB00325

Meylers Side Effects of Drugs - Elsevier Science & Technology - Literati by CredoMeyler's Side Effects of Drugs - Elsevier Science & Technology - Literati by Credo

This updated edition in the long standing series provides the latest information on many individual drugs, including the most complete coverage of their adverse reactions and interactions.
more infohttps://corp.credoreference.com/component/booktracker/edition/11102.html
  • Amrinone decreases the pulmonary capillary wedge pressure while increasing cardiac output because it functions as an arterial vasodilator and increases venous capacitance while decreasing venous return. (wikipedia.org)
  • An increase in cAMP with the administration of amrinone in vascular smooth muscle produces vasodilation by facilitating calcium uptake by the sarcoplasmic reticulum (a special type of smooth ER) and decreasing the calcium available for contraction. (wikipedia.org)
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