A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
Pyridines substituted in any position with an amino group. May be hydrogenated, but must retain at least one double bond.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
Application of heat to correct hypothermia, accidental or induced.
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.

Effects of single administration of a phosphodiesterase III inhibitor during cardiopulmonary bypass: comparison of milrinone and amrinone. (1/66)

The effects of phosphodiesterase III (PDE III) inhibitors administered after aortic declamping during cardiopulmonary bypass (CPB) for open heart surgery were investigated. Ten patients (group M) were administered milrinone (50 microg/kg) after aortic declamping during CPB, 10 patients were administered amrinone (1 mg/kg) at the same time during their surgery (group A), and 10 patients served as controls with no drug administered (group C). Soon after bolus infusion of the PDE III inhibitor, perfusion pressure dropped significantly in groups M and A. However, after release of CPB and at the end of surgery, there was no difference in aortic pressure between the 3 groups. There were also no differences between the groups in heart rate, pulmonary artery pressure, and pulmonary capillary wedge pressure. After weaning from CPB, the cardiac index was high and systemic vascular resistance index was low in groups M and A. There were no significant differences in the need for additional catecholamines and time for rewarming between groups. No adverse reactions were observed. A single administration of a PDE III inhibitor during CPB was useful for post-CPB management of patients undergoing open heart surgery. Amrinone reduced perfusion pressures more than milrinone, but cardiac indices and aortic pressures after weaning from CPB showed no differences between group M and group A patients.  (+info)

Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1. (2/66)

The effects of amrinone, a selective phosphodiesterase III inhibitor, on liver ischaemia reperfusion injury have not yet been clarified. Forty-five patients with hepatocellular carcinoma who underwent partial liver resection using Pringle's manoeuvre were studied. Patients were divided into three groups: those given amrinone, those given prostaglandin E1 (PGE1) and those not treated (controls). An indocyanine green (ICG) clearance test was performed before the operation and three times during surgery: just before induction of liver ischaemia, just after liver resection and 60 min after reperfusion. Blood lactate and base excess were measured at the same times. Systolic and diastolic arterial pressure, heart rate, cardiac index and oesophageal temperature were monitored. Aminotransferase levels were recorded the day before surgery, 1 h after operation and on the first and third postoperative days. These data were compared between groups. The ICG elimination rate, lactate and base excess in the amrinone group differed significantly from those in controls during the observation period (P = 0.03, P = 0.04 and P = 0.03, respectively). The differences between the PGE1 and control groups were not significant. There were no significant differences between the groups in perioperative vital signs, cardiac index or postoperative aminotransferase. Amrinone enhanced intraoperative ICG elimination in cirrhotic patients who underwent liver resection.  (+info)

Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro. (3/66)

An experimental study was done to examine a potential role of phosphodiesterase (PDE) inhibitors in the treatment of diabetic erectile dysfunction. Relaxant effect of specific PDE inhibitors were measured in strips of corpus cavernosum smooth muscle taken from control and diabetic groups. Diabetes mellitus was induced in New Zealand white rabbits using alloxan. Penises excised from diabetic rabbits 8 weeks after the induction of diabetes mellitus. In the organ bath strips from control and diabetic rabbit corpus cavernosum were precontracted and increasing doses of several PDE inhibitors were added. In the precontracted rabbit cavernous tissue, sulmazole and zaprinast specific PDE V inhibitors were equally potent and efficacious in vitro but amrinone, a specific PDE III inhibitor, exhibits low relaxant effects. All PDE inhibitors tested showed a similar relaxation effect on corpus cavernosum smooth muscle from control and 8-week diabetic rabbits. The present study provides the possibility of using selective PDE III and V inhibitors in the treatment of diabetic impotence.  (+info)

Lack of role for nitric oxide in cholinergic modulation of myocardial contractility in vivo. (4/66)

Despite intensive investigation, the role of nitric oxide (NO) in cholinergic modulation of myocardial contractility remains unresolved. The left anterior descending coronary artery of 34 anesthetized, open-chest dogs was perfused via an extracorporeal circuit. Segmental shortening (SS) was measured with ultrasonic crystals and coronary blood flow (CBF) was measured with an ultrasonic flow transducer. An intracoronary infusion of ACh (20 microg/min) was performed, with CBF held constant, under baseline and during dobutamine, CaCl(2), or amrinone at doses increasing SS by approximately 50% (10 microg/min, 15 mg/min, and 300 microg/min ic, respectively). ACh-induced responses during dobutamine were also assessed following treatment with the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME; 300 microg/min ic for 15 min). The effects of sodium nitroprusside (SNP; 80 microg/min ic), an exogenous NO donor, bradykinin (2.5 microg/min ic), a nonmuscarinic releaser of endothelial NO, and bilateral vagal stimulation (before and after L-NAME) were evaluated during dobutamine. ACh had no effect on SS under baseline or during CaCl(2), but it decreased SS during dobutamine or amrinone (-23 +/- 4% and -30 +/- 5%, respectively). Vagal stimulation also reduced SS during dobutamine. L-NAME did not alter the ACh- or vagal-induced decreases in SS during dobutamine. Neither SNP nor bradykinin affected SS during dobutamine. In conclusion, ACh and vagal stimulation have a negative inotropic effect during stimulation of the beta-adrenergic receptors that is independent of NO. The persistence of this effect during amrinone suggests that a mechanism downstream from adenylate cyclase is involved.  (+info)

In contrast to forskolin and 3-isobutyl-1-methylxanthine, amrinone stimulates the cardiac voltage-sensitive release mechanism without increasing calcium-induced calcium release. (5/66)

The objective of this study was to determine whether the voltage-sensitive release mechanism (VSRM) can be stimulated independently from Ca(2+)-induced Ca(2+) release (CICR) by drugs that elevate intracellular cAMP. Contractions were measured in voltage-clamped guinea pig ventricular myocytes at 37 degrees C. Na(+) current was blocked. We compared effects of agents that elevate cAMP through activation of adenylyl cyclase (1 microM forskolin), nonspecific inhibition of phosphodiesterases (PDEs) [100 microM 3-isobutyl-1-methylxanthine (IBMX)], and selective inhibition of PDE III (100-500 microM amrinone) on contractions initiated by the VSRM and CICR. Forskolin and IBMX significantly increased peak Ca(2+) current and CICR. In addition, these agents also markedly increased contractions elicited by test steps from -65 to -40 mV, which activate the VSRM. However, because these steps also induced inward current in the presence of forskolin or IBMX, CICR could not be excluded. In contrast, amrinone caused a large, concentration-dependent increase in VSRM contractions but had no effect on CICR contractions or Ca(2+) current. Sarcoplasmic reticulum Ca(2+), assessed by rapid application of caffeine (10 mM), was increased only modestly by all three drugs. Normalization of contractions to caffeine contractures indicated that amrinone increased fractional release by the VSRM, but not CICR. Forskolin and IBMX increased fractional release elicited by steps to -40 mV. Increases in CICR induced by forskolin and IBMX were proportional to caffeine contractures. Thus, positive inotropic effects of cAMP on VSRM contractions may be compartmentalized separately from effects on Ca(2+) current and CICR.  (+info)

Amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures. (6/66)

We investigated the effects of i.v. amrinone on intraoperative changes of core temperature during deliberate mild hypothermia for neurosurgery. The patients in a control group (n=10) did not receive amrinone and patients in the amrinone group (n=10) received amrinone 5 microg kg(-1) min(-1) after a loading dose of 1.0 mg kg(-1). Anaesthesia was maintained with nitrous oxide in oxygen, propofol and fentanyl. After the induction of anaesthesia, patients were cooled and tympanic membrane temperature was maintained at 34.5 degrees C. After completion of the main surgical procedures, patients were rewarmed in the operating room. Tympanic membrane temperatures between 30 and 90 min after cooling were significantly lower in the amrinone group than in the control group. During cooling, the times taken to cool to 35 degrees C and to the lowest temperature were significantly shorter in the amrinone group than in the control group. These results suggest that i.v. amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures.  (+info)

High-dose amrinone is required to accelerate rewarming from deliberate mild intraoperative hypothermia for neurosurgical procedures. (7/66)

BACKGROUND: Since the time available to provide the cooling and rewarming is limited during deliberate mild hypothermia, the technique to accelerate the cooling and rewarming rate of core temperature has been studied. Amrinone has been reported to accelerate the cooling rate but not the rewarming rate of core temperature during deliberate mild hypothermia. The failure of amrinone effect on the rewarming rate might be due to an insufficient dose of amrinone during hypothermic conditions. The authors therefore tested whether higher doses of amrinone can accelerate the rewarming rate of core temperature during deliberate mild hypothermia for neurosurgery. METHODS: After institutional approval and informed consent, 30 patients were randomly assigned to one of three groups. Patients in the control group (n = 10) did not receive amrinone; patients in the AMR 15 group (n = 10) received 15 microg x kg(-1) x min(-1) amrinone with a 1.0-mg/kg loading dose of amrinone at the beginning of cooling; and patients in the ReAMR group (n = 10) received 5 microg x kg(-1) x min(-1) amrinone with 1.0-mg/kg loading and reloading doses of amrinone at the beginning of cooling and rewarming, respectively. Administration of amrinone was started just after the induction of cooling and continued until the end of anesthesia. Anesthesia was maintained with nitrous oxide in oxygen, propofol, and fentanyl. After induction of anesthesia, patients were cooled, and tympanic membrane temperature was maintained at 34.5 degrees C. After completion of the main surgical procedures, patients were actively rewarmed and extubated in the operating room. RESULTS: The cooling and rewarming rates of core temperature were both significantly faster in both amrinone groups than in the control group. During the cooling and rewarming periods, forearm minus fingertip temperature gradient was significantly smaller in both amrinone groups than in the control group. During the rewarming period, heart rate and mean arterial pressure in the AMR 15 group were significantly faster and lower, respectively, than in the control group. Systemic vascular resistance in the AMR 15 group was smaller than in the control group throughout the study; on the other hand, only the value after the start of rewarming in the ReAMR group was smaller than in the control group. CONCLUSIONS: Amrinone at an infusion rate of 15 or 5 microg x kg(-1) x min(-1) with a reloading at the beginning of rewarming accelerated the rewarming rate of core temperature during deliberate mild hypothermia. This suggests that high-dose amrinone is required to accelerate rewarming from deliberate mild intraoperative hypothermia for neurosurgical procedures.  (+info)

Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. (8/66)

BACKGROUND: Mounting evidence links systemic and local inflammatory cytokine production to myocardial dysfunction and injury occurring during ischemia-reperfusion, cardiopulmonary bypass, and heart failure. Phosphodiesterase inhibitors (PDEIs), used frequently in these states, can modulate inflammatory signaling. The mechanisms for these effects are unclear. We therefore examined the effects of 2 commonly used PDEIs, amrinone and milrinone, on cardiac cell inflammatory responses. METHODS AND RESULTS: Primary rat cardiomyocyte cultures were treated with endotoxin (LPS) or tumor necrosis factor-alpha (TNF-alpha), alone or in the presence of clinically relevant concentrations of amrinone or milrinone. Regulation of nuclear factor-kappa B (NFkappaB), nitric oxide synthase and cyclooxygenase isoforms, and cytokine production were assessed by electrophoretic mobility shift assays, Western immunoblotting, and enzyme-linked immunoassays, respectively. Both LPS and TNF-alpha induced significant NFkappaB activation, cyclooxygenase-2 (COX-2) expression, and inducible NO synthase (iNOS) and cytokine production; with the exception of COX-2 expression, all were significantly reduced by amrinone, beginning at concentrations of 10 to 50 micro mol/L. In contrast, milrinone increased nuclear NFkappaB translocation, iNOS and COX-2 expression, and cardiomyocyte production of interleukin-1beta. Cell-permeable cAMP increased inflammatory gene expression, whereas cell-permeable cGMP had no effect, indicating that the effects of amrinone were not due to phosphodiesterase inhibition. Similar results were seen in macrophages and coronary vascular endothelial cells. CONCLUSIONS: Both amrinone and milrinone have significant effects on cardiac inflammatory signaling. Overall, amrinone reduces activation of the key transcription factor NFkappaB and limits the production of pro-inflammatory cytokines, whereas milrinone does not.  (+info)

Amrinone is a nonglycosidic, non-catecholamine-dependent, inotropic vasodilator agent that has recently been made available for intravenous use in patients with severe heart failure. Because other agents, such as dopamine, dobutamine, and nitroprusside, are available and have actions similar to those of amrinone in patients with heart failure, the usefulness of this newer agent must be put in perspective.. Amrinone is advertised as a major advance in inotropic therapy because of its alleged advantages of more sustained action than dopamine or dobutamine and reduction of myocardial oxygen demand. The evidence for these claims and their importance appears minimal. Recent reports indicate ...
In a prospective trial, the immediate and long-term haematological effects of amrinone were studied in sixteen patients with refractory cardiac failure. The platelet count was significantly and variably reduced in all patients and the reduction was related to log plasma amrinone concentration. Platelet survival was significantly reduced in those cases studied. No evidence of disseminated intravascular coagulation or intravascular platelet deposition was observed and the reduced platelet survival was not considered to be the result of an immunological process. Evidence of a marrow response to the reduced platelet count and survival was seen. Although no haemorrhagic symptoms were observed in the patients, the haematological side-effects were considered to be of such severity as to limit the use of this drug in clinical practice ...
Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). The positive inotropic effect of amrinone is mediated by the selective enhancement of high gain CICR which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways. Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. There is a long-standing controversy regarding whether the drug actually increases cardiac contractility in diseased myocardium (and therefore whether it is of any clinical use). The issue has been reviewed extensively by Dr Peter Wilmshurst, one ...
Acute kidney injury frequently accompanies sepsis. Endotoxin is known to reduce tissue levels of cAMP and low levels of cAMP have been associated with renal injury. We, therefore, hypothesized that endotoxin induced renal injury by activating phosphodiesterase 3 (PDE3) which metabolizes cAMP and that amrinone an inhibitor of PDE3 would prevent the renal injury. Animals were divided into three groups (n = 7/group): 1) Control (0.9% NaCl infusion without LPS); 2) LPS (0.9% NaCl infusion with LPS); 3) Amrinone+LPS (Amrinone infusion with LPS). Either lipopolysaccharide (LPS) or vehicle was injected via the jugular vein and the rats followed for 3 hours. We explored the expression of PDE3 isoenzymes and the concentrations of cAMP in the tissue. The PDE3B gene but not PDE3A was upregulated in the kidney of LPS group. Immunohistochemistry also showed that PDE3B was expressed in the distal tubule in the controls and LPS caused PDE3B expression in the proximal as well. However, PDE3A was not expressed in the
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Integrated lens antennas (ILAs) are essentially high-gain (sub)millimeter-wave radiating structures. They often have a moderate (or even poor) aperture eff
In mice, injected fragments of a naturally occurring protein boost memory in young and old animals and improve cognition and mobility in a model of neurodegenerative disease. 0 Comments. ...
TY - GEN. T1 - A novel compact high-gain filtenna using gap waveguide technology. AU - Farahani, H. S.. AU - Bosch, W.. PY - 2019/7/1. Y1 - 2019/7/1. N2 - A novel compact filtering antenna (Filtenna) using groove gap waveguide (GGW) technology is presented. The use of GGW structures built by defected periodic metallic posts is an attractive way to achieve high-performance and at the same time, low-cost microwave devices and antennas. The proposed antenna consists of a slotted GGW array antenna operating in Ku-band frequencies which is effectively fed through a fourth-order chebyshev bandpass filter. The proposed Filtenna exhibits good out-of-band suppression and high gain radiation pattern.. AB - A novel compact filtering antenna (Filtenna) using groove gap waveguide (GGW) technology is presented. The use of GGW structures built by defected periodic metallic posts is an attractive way to achieve high-performance and at the same time, low-cost microwave devices and antennas. The proposed antenna ...
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Pirbuterol (trade name Maxair) is a short-acting β2 adrenoreceptor agonist with bronchodilating action used in the treatment of asthma, available (as pirbuterol acetate) as a breath-activated metered-dose inhaler (Maxair Autohaler). Pirbuterol is used in asthma for reversal of acute bronchospasm, and also as a maintenance medication to prevent future attacks. It should be used in patients 12 years of age and older with or without concurrent theophylline and/or inhaled corticosteroid. After inhalation of doses up to 800 μg (twice the maximum recommended dose) systemic blood levels of pirbuterol are below the limit of assay sensitivity (2-5 ng/ml). A mean of 51% of the dose is recovered in urine as pirbuterol plus its sulfate conjugate following administration by aerosol. Pirbuterol is not metabolized by catechol-O-methyltransferase. The plasma half-life measured after oral administration is about two hours. Maxair Autohaler (pirbuterol acetate inhalation aerosol) For Oral Inhalation Only. U.S. ...
Defined as RVH (and subsequent ventricular dysfunction) secondary to chronic pulmonary hypertension. The key to management in these patients is to avoid increasing PVR (precipitants include hypoxemia, hypercarbia, acidosis, nitrous oxide [Hilgenberg JC et al. Anesth Analg 59: 323, 1980]). In severe cases, beta-agonists may be required to overcome PVH, but with the concomitant risk of myocardial ischemia. Phosphodiesterase inhibitors (amrinone, milrinone) may be needed as they can both improve ventricular function and induce vasodilation (thus reducing afterload).. ...
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Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells,
Web: ewh.ieee.org/r6/scv/emc Choosing the right antenna for radiated immunity measurements can be quite challenging, especially above 1 GHz.? On the one hand, a high-gain antenna is desired to reduce the amplifier power needed.? On the other hand, the 3-dB-beamwidth needs to be taken into account to maximize the illuminated area.? This is especially true for measurements according to IEC61000-4-3, MIL-STD 461 or full-vehicle testing according to MIL-STD 464 ...
We report on investigation the potential of a 7 wt% (8.35 × 1020 Tm3+/cm3) doped silicate fibers for high-gain fiber amplifiers. Such a high ion concentration significantly reduces the required fiber length of high-power 2 μm fiber laser systems and allows the high-repetition rate operation in 2 μm mode-locked fiber lasers. To evaluate the feasibility of extracting high gain-per-unit-length from this gain medium, we measure several key material properties of the silicate fiber, including the absorption/emission cross-sections, upper-state lifetime, fiber background loss, and photodarkening resistance. We show through numerical simulations that a signal gain-per-unit-length of 3.78 dB/cm at 1950 nm can be achieved in a watt-level core-pumped Tm3+-doped silicate fiber amplifier. In addition, an 18-dB 2013-nm amplifier is demonstrated in a 50-cm 7 wt% Tm3+-doped double-clad silicate fiber. Finally, we experimentally confirm that the reported silicate host exhibits no observable photodarkening.
Bupivacaine-induced myocardial depression and pulmonary edema: a case report.: Central nervous system and cardiovascular toxicity are well-known side effects of
Nokia sites use cookies to improve and personalize your experience and to display advertisements. The sites may also include cookies from third parties. By using this site, you consent to the use of cookies. Learn more ...
Pirbuterol - Get up-to-date information on Pirbuterol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Pirbuterol
Pirbuterol - Get up-to-date information on Pirbuterol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Pirbuterol
Sigma-Aldrich offers abstracts and full-text articles by [Rongrong Li, He Ma, Xiaojin Zhang, Chuanfu Li, Jingwei Xiong, Ting Lu, Yu Mao, Juncheng Dai, Li Liu, Zhengnian Ding].
J.B. Michael, M.R. Edwards, A. Dogariu and R.B. Miles, Femtosecond laser electronic excitation tagging for quantitative velocimetry imaging in air, Applied Optics 50, 5158 (2011). doi:10.1364/AO.50.005158 Dogariu, J.B. Michael, M.O. Scully and R.B. Miles, High-gain backward lasing in air, Science 331, 442 (2011). doi:10.1126/science. ...
Deliberant 802.11 an MiMo 18 dBi dual pol panel(DLB-APC-5M-18) The APC 5M-18 delivers the highest performance and stability available in the 5 GHz CPE class. This product combines a robust IP-67 compliant enclosure with a highly advanced 802.11n radio core containing MIMO 2x2 technology along with an integrated high-gain dual polarization directional antenna. The device is powered by a reliable, advanced, and feature-rich operating system, allowing the creation of very high throughput and stable wireless networks quickly, safely, and effectively. In addition, the APC 5M-18 supports access point operating mode which extends application scenarios and makes the APC 5M-18 suited for both point to point and point to multipoint networks. The robust software engine allows the APC 5M-18 to work as bridge or as a router, provides a user-friendly Adobe Flex - based GUI with instant changes, includes useful installation tools (Site survey, Antenna alignment, Delayed reboot, Spectrum analyzer), and also is
Trichloroethanes: Chlorinated ethanes which are used extensively as industrial solvents. They have been utilized in numerous home-use products including spot remover preparations and inhalant decongestant sprays. These compounds cause central nervous system and cardiovascular depression and are hepatotoxic. Include 1,1,1- and 1,1,2-isomers.
Alkalis Are Toxic To Pets Clinical signs are agitation, aggression, vomiting, diarrhea, drooling, tremors, & respiratory or cardiovascular depression.
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Dimensions US-BIOTA São Paulo: integrando disciplinas para a predição da biodiversidade da Floresta Atlântica no Brasil. Auxílio à Pesquisa Programa BIOTA Temático. Cristina Yumi Miyaki. Ciências Biológicas
Wernovsky G, Wypij D, Jonas RA, Mayer JE, Jr., Hanley FL, Hickey PR Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. A comparison of low-flow cardiopulmonary bypass and circulatory arrest. Circulation 1995;92;(8.);2226-35.. Chandler HK, Kirsh R.Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease.Curr Cardiol Rev.2016;12(2):107-111.. Lobos A-T., Lee S., Menon K. Capillary refill time and cardiac output in children undergoing cardiac catheterization. Pediatr. Crit. Care Med. 2012;13(2):136-140. doi: 10.1097/PCC.0b013e31 8220afdc.. Kikura M, Sato S. The efficacy of preemptive Milrinone or Amrinone therapy in patients undergoing coronary artery bypass grafting. 2002 Jan;94(1):22-30.. Kauffman RF, Schenck KW, Utterback BG, Crowe VG, Cohen ML: In vitro vascular relaxation by new inotropic agents: relationship to phosphodiesterase inhibition and cyclic nucleotides. J Pharmacol Exp Ther 1987; ...
AX6600 Whole Home Mesh Wi-Fi System (1-pack). The TP-Link Wifi 6 AX6600 X90 Whole-Home Mesh Wifi router provides wireless connection at up to 6600Mbps at 5GHz and 574Mbps at 2.4GHz for up to 6000Mbps bandwidth. Armed with Wi-Fi 6 technology, the Deco mesh Wi-Fi is designed to deliver a huge boost in coverage, speed, and total capacity. The TP-Link Mesh router technology allows your Deco units to work together to form a unified network with a single network name. Enjoy uninterrupted streaming, downloading, gaming and more as you move through your home. Supports connections from up to 200 devices. Armed with AI-Driven Mesh technology, Deco X90 automatically learns and improves itself from experience. This provides the ideal mesh Wi-Fi unique to your home and network environment. Walk through your home and enjoy seamless streaming at the fastest possible speeds. With Built-in 4x high-gain antennas and 2 smart antennas, it uses intelligent algorithms to auto-detect other Deco units locations and
Qorvo has expanded its offering for 5G applications with the industrys first 28 GHz Gallium Nitride (GaN) front-end module (FEM). This new FEM reduces overall system costs for base station equipment manufacturers as they expand into 5G. The QPF4001 FEM integrates a high linearity LNA, a low loss transmit/receive switch and a high-gain, high efficiency multi-stage PA in a single MMIC. The compact 5x4 mm air-cavity laminate surface mount package is optimized for the phased array element spacing at 28 GHz for 5G base station architectures.Qorvos new GaN FEM enables smaller, more powerful and efficient millimeter-wave, phased array systems, which will steer signals to areas of greater bandwidth demand. Using Qorvos highly efficient 0.15-micron GaN-on-SiC technology in this application allows the user to more efficiently achieve higher EIRP levels while minimizing array size and power dissipation, resulting in a lower cost system.
Looking for thermal agitation? Find out information about thermal agitation. Random movements of the free electrons in a conductor, producing noise signals that may become noticeable when they occur at the input of a high-gain... Explanation of thermal agitation
Cherry Is Toxic To Dogs Clinical signs are agitation, aggression, vomiting, diarrhea, drooling, tremors, & respiratory or cardiovascular depression.
Manganese superoxide dismutase (SOD2) is a key enzyme to scavenge free radical superoxide in the mitochondrion. SOD2 deficiency leads to oxidative injury in cells. Bupivacaine, a local anesthetic commonly used in clinic, could induce neurotoxic injury via oxidative stress. The role and the mechanism of SOD2 regulation in bupivacaine-induced oxidative stress remains unclear. Here, bupivacaine was used to treat Sprague-Dawley rats with intrathecal injection and culture human neuroblastoma cells for developing vivo injury model and vitro injury model. The results showed that bupivacaine caused the over-production of mitochondrial reactive oxygen species (mtROS), the activation of C-Jun N-terminal kinase (JNK), and the elevation of SOD2 transcription. Decrease of mtROS with N-acetyl-L-cysteine attenuated the activation of JNK and the increase of SOD2 transcription. Inhibition of JNK signaling with a small interfering RNA (siRNA) or with sp600125 down-regulated the increase of SOD2 transcription. SOD2 gene
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Researchers have identified a new druggable target for heart failure in neonates and infants, a condition for which there has been no specific treatment. Approximately 60 percent of children born with congenital heart abnormalities will develop overt heart failure within the first year of life. The progression of heart failure in these infants is often rapid, with a high frequency of fatalities. Stimulation of this target significantly increased the cardiac contractility of newborns and infants in mice with few side effects such as tachycardia, arrhythmias, and increased myocardial oxygen consumption, which are common problems with many cardiotonic drugs.
The complex cation ligand [Ru(pytpy)2]2+ (pytpy = 4′-(4-pyridyl)-2,2′∶6′,2″-terpyridine) is an expanded 4,4′-bipyridine; we describe the first example of a coordination polymer in which [Ru(pytpy)2]2+ plays the role of a bridging bidentate ligand. RACI100: Celebrating Australian Chemistry
Opioids are considered the golden standard in pain management for both humans and small animals, but is used less often in equine medicine - probably for fear of side effects. Are there any studies that suggest that side effects are a major problem, or is it lack of experience which is the greatest obstacle to use? As early as 1937 it was shown that morphine and morphine derivatives provide analgesia in horses. For species other than horses used opioids often both pre-, intra-and postoperatively. They relieve pain effectively and are often included in the anesthesia protocol. That way you can reduce the need for anesthetic gases and thus the risk of cardiovascular depression. In horses, it seems that there is a fine line between analgesia and excitation, which must be taken into account when used. There are also a number of side effects, mainly gastrointestinal, that makes people reluctant to use opioids. There is also a concern that the pain relief will mask a progressive disease state. This ...
SF 349, an analogue of milrinone, was being developed at a number of universities in Italy as a cardiotonic agent. It was in preclinical investigation and
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2,2′-Bipyridine (2,2′-bipy) is a chelating ligand that forms complexes with most transition metal ions that are of broad academic interest. Many of these complexes have distinctive optical properties, and some are of interest for analysis. Its complexes are used in studies of electron and energy transfer, supramolecular and materials chemistry, and catalysis.. 2,2′-Bipyridine is used in the manufacture of diquat.. ...
The spacecraft provides the power, pointing and telemetry for the photometer. Other than the four reaction wheels used to maintain the precision pointing and an ejectable cover, there are no other moving or deployable parts on the spacecraft. Image Credit: NASA Ames/Ball Aerospace.. In the second stage, testing will investigate RW2s ability to help control the spacecraft pointing with enough accuracy to transmit science data to the ground using NASAs Deep Space Network. If RW2 can sustain coarse-point in stage 1, the second stage of the test will be to point the high-gain antenna to Earth and downlink the data currently stored aboard. This requires that the pointing be controlled more tightly than simply avoiding safe mode, yet does not require the very fine control needed to return to science data collection.. The final stage of the test will determine if RW2 can achieve and maintain fine-point, the operating mode for collecting science data. During fine-point the fine-guidance sensors ...
50525-27-4 - UUSPGQXHSZVVNL-UHFFFAOYSA-L - Tris(bipyridine)ruthenium(II) chloride hexahydrate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Cyclohexamines work in a different manner than most other agents by stimulating the CNS rather than depressing it. This stimulation results in what is termed dissociative anesthesia or catalepsy, in which animals are in a trancelike state unaware of their surroundings. Stimulation of the CNS produces muscle rigidity characterized by extension of the front limbs and head and neck flexed back, increased reflexes such as the palpebral and pharyngeal, and sensitivity to light, sound, and touch. These effects can be diminished by using a benzodiazepine, opiate, or tranquilizer in combination with the cyclohexamine. Cyclohexamines typically do not cause cardiovascular depression. More often, tachycardia and increased blood pressure are seen after administration of a cyclohexamine due to indirect sympathetic stimulation. Because of this, they are not recommended for use in animals with known cardiac disease. Apneustic respirations are commonly seen. This is a particular type of breathing pattern in ...
Milrinone is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries. Milrinone is used as a short-term treatment for life-threatening heart failure. Milrinone may also be used for...
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We report on the design and fabrication of ZnO-based integrated inverters consisting of normally-on metal-semiconductor field-effect transistors and AgxO Schottky diodes as level shifters. The inverters show high gain values up to 197 at 3 V operating voltage and low uncertainty levels in the range of 0.13 V. The influence of the level shifter and the channel material/thickness on the performance of the inverters has been investigated. Using Zn0.997Mg0.003O for the channel thin film leads to high reproducibility (90%) of the devices. A logic NOR-gate has been implemented showing the possibility to fabricate a complete logic ...
South Korean electronics giant LG Electronics announced this week its researchers had successfully sent data signals using the new communication technology. In the experiment, information was sent 100 metres wirelessly using the 6G terahertz spectrum, setting a new record for the tech.. Both 5G and 6G work using radio frequencies to transmit data wirelessly. However, 6G uses higher frequencies than the older technology - much like 5G uses higher bands than 4G. It also incorporates new technologies like adaptive beamforming, high-gain antenna switching and even artificial intelligence.. Once up and running, 6G promises to be really, really fast. Experts think it will be able to send an incredible 1 terabyte of data per second. Thats a vast improvement over even home broadband networks, which at the moment top out at 1 gigabit per second, if youre lucky. ...
If all goes according to plan, within about 10 minutes after separation from the Centaur, each MarCO will begin to deploy its solar panels. Each MarCO generates electric power with a pair of photovoltaic panels, and each panel has an area of about 12 inches by 12 inches (30 centimeters by 30 centimeters). Combined, these panels can provide each spacecraft about 35 watts when near Earth and 17 watts when near Mars. The power system also will use rechargeable lithium-ion battery cells, crucial for operations when spacecraft orientation for communication prevents the solar arrays from facing the Sun.. After the solar arrays are deployed, the MarCO control team will acquire radio contact with each CubeSat, one at a time, via NASAs Deep Space Network. Early tasks will be to establish that the spacecraft are healthy, stable and commandable. During the flight to Mars, the MarCO twins will each attempt to deploy a high-gain X-band antenna that is a flat reflectarray panel engineered to direct radio ...
The bupivacaine-induced generation of reactive oxygen species (ROS), which was initiated within 5 hrs and preceded the activation of caspase-3 and poly ADP-ribose polymerase (PARP) degradation, was suggested to trigger apoptosis, exhibited by Hoechst 33258 nuclear staining and DNA fragmentation ...
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Milrinone Milrinone Systematic (IUPAC) name 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile Identifiers CAS number 78415-72-2 ATC code C01CE02 PubChem
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Several new iridium(iii) and rhodium(iii) complexes bearing 5-methyltetrazolate (MeCN4−) have been prepared, and their structures in the crystals and in solution have been determined by X-ray analysis and by NMR spectroscopy, respectively. In the crystals of the mononuclear complexes, κN2-coordination of MeCN4− was
Sometime tomorrow, the plan is to discontinue Pattys milrinone transfusion, at least temporarily. Im nervous about the effect on Patty, as I was when the dose was halved. With the reduced dose, she seems to have less energy than when she was receiving the full amount. Well keep you posted about what happens. On the plus side, she wont have to lug around the big bag with the pump, so shell at least enjoy a modicum of freedom ...
A new dinuclear RuII polypyridyl complex, [(bpy)2Ru(H2bpip)Ru(bpy)2]4+ (RuH2bpip, bpy=2,2‐bipyridine, H2bpip=2,6‐pyridyl(imidazo[4,5‐f][1,10]phenanthroline ...
Vetmedin (Pimobendan) is in a class of heart treatments named inodilators used in the management of certain types of congestive heart failure in dogs.
There is a net decrease in myocardial wall tension, and O2 consumption when using amrinone. Amrinone also has beneficial ... Both inotropic and lusitropic effects justify the use of amrinone to treat heart failure. Amrinone decreases the pulmonary ... Amrinone is the INN, while inamrinone is the United States Adopted Name, which was adopted in 2000 in an attempt to avoid ... Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may ...
Amrinone, milrinone and enoximone are used clinically for short-term treatment of cardiac failure in the presence of ... Approved PDE3 inhibitors include the following: amrinone cilostazol milrinone enoximone pimobendan (approved for human use in ...
Fludrocortisone Positive inotropic agents Cardiac glycosides Strophantin K Convallatoxin Digoxin PDE3 inhibitors Amrinone ...
... amrinone MeSH D03.383.725.050.085.543 - milrinone MeSH D03.383.725.050.440 - methapyrilene MeSH D03.383.725.050.610 - ...
... combinations C01CE01 Amrinone C01CE02 Milrinone C01CE03 Enoximone C01CE04 Bucladesine QC01CE90 Pimobendane C01CX06 ...
... amrinone MeSH D02.092.080.085.543 - milrinone MeSH D02.092.146.100 - aminophenols MeSH D02.092.146.100.700 - phenetidine MeSH ...
Amrinone amrinone (INN) amrubicin (INN) amsacrine (INN) amsilarotene (USAN) amtolmetin guacil (INN) amustaline dihydrochloride ...
Angiotensin II Eicosanoids Prostaglandins Phosphodiesterase inhibitors Enoximone Milrinone Amrinone Theophylline Glucagon ...
... approached The Guardian newspaper with a substantial dossier detailing alleged misconduct in the development of Amrinone, a ...
Amrinone, milrinone and enoximone are used clinically for short-term treatment of cardiac failure. These drugs mimic ...
MECHANISM OF ACTION OF AMRINONE ON AIRWAYS W. C. Lenox, M.D.; W. C. Lenox, M.D. ... W. C. Lenox, R. A. Sauder, R. Grayson, J. D. Tobias, C. A. Hirshman; MECHANISM OF ACTION OF AMRINONE ON AIRWAYS. Anesthesiology ... Amrinone Is Superior to Epinephrine in Reversing Bupivacaine-induced Cardiovascular Depression in Sevoflurane-anesthetized Dogs ... High-dose Amrinone Is Required to Accelerate Rewarming from Deliberate Mild Intraoperative Hypothermia for Neurosurgical ...
Use of amrinone and glucagon in a case of calcium channel blocker overdose. Ann Emerg Med. 1993 Jul. 22(7):1225-8. [QxMD ... Amrinone as an antidote in experimental verapamil overdose. Acad Emerg Med. 1996 Aug. 3(8):762-7. [QxMD MEDLINE Link]. ... Tuncok Y, Apaydin S, Kalkan S, Ates M, Guven H. The effects of amrinone and glucagon on verapamil-induced cardiovascular ...
Use of amrinone and glucagon in a case of calcium channel blocker overdose. Ann Emerg Med. 1993 Jul. 22(7):1225-8. [QxMD ... Amrinone as an antidote in experimental verapamil overdose. Acad Emerg Med. 1996 Aug. 3(8):762-7. [QxMD MEDLINE Link]. ... Tuncok Y, Apaydin S, Kalkan S, Ates M, Guven H. The effects of amrinone and glucagon on verapamil-induced cardiovascular ...
Metabolism of amrinone in animals. Baker JF, Chalecki BW, Benziger DP, OMelia PE, Clemans SD, Edelson J. Baker JF, et al. ... Pharmacokinetics of the bipyridines amrinone and milrinone. Edelson J, Stroshane R, Benziger DP, Cody R, Benotti J, Hood WB Jr ...
Digoxin, dobutamine or amrinone can help the heart muscle contract. However, these are only recommended as a short term ...
Amrinone and its deriv-atives have been present. These procedures must be strictly used only until larger catheters having a ...
However, the maximal inhibition of PDE by MCI-154 remained less than 18%. Amrinone, milrinone and papaverine inhibited more ... and that MCI-154 may have novel mechanisms of action different from those of amrinone, milrinone and CI-914 that are largely ... Carbachol at a concentration known to decrease markedly the PIE of amrinone, milrinone and papaverine, did not affect the PIE ...
Comparison of milrinone and amrinone. JPN Circ J, 1999 Aug; 63 (8): 605-9.. 12. Chang AC, Atz AM, Wernovsky G, Burke RP, Wessel ...
containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone. ...
Amrinone. approved. yes. inhibitor. Details. DB01954. Rolipram. investigational. yes. inhibitor. Details. DB01656. Roflumilast ...
AMRINONE LACTATE 50280 AMYL NITRITE 50281 AMYL PHENOL 50283 AMYLASE 50284 ANETHOLE 50285 ANILERIDINE 50290 ANISE OIL 50295 ...
... a drug company which had tried to suppress his negative findings about the cardiac drug amrinone. (He was able to blow the ...
Amrinone: Contemporary Management of the Low Cardiac Output Syndrome. *Issue 6December 1989p679-833 ...
Amrinone - 0.75 - 3 mg loading dose over three minutes, a maintenance infusion of 5 μg/kg/min ...
Acid solutions, including other parenteral medications (e.g., labetalol, ciprofloxacin, amrinone, milrinone) must not be ...
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Amrinone (inamrinone) and cilostazol are significantly selective for the PDE3 isozymes over the other PDEs tested [8]. ...
Acid solutions, including other parenteral medications (e.g., labetalol, ciprofloxacin, amrinone, milrinone) must not be ...
Product containing amrinone (medicinal product). Code System Preferred Concept Name. Product containing amrinone (medicinal ...
Amrinone - Preferred Concept UI. M0001038. Scope note. A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator ... Amrinone Entry term(s):. 5-Amino-(3,4-bipyridine)-6(1H)-one. Amrinon. Cordemcura. Inocor. Win 40680. Win-40680. Win40680. ...
Effects of amrinone on pulmonary hemodynamics and pulmonary gas exchange in highland piglets]. Xie, Z Z. ...
Amrinone Drugs : Dose, Action, side effects and Contra-indications. Amrinone is a positive inotropic agent and ... Now a day Amrinone is not used because of toxicity effect; long term uses shown increase mortality. Dose of Amrino...( read ...
Use of amrinone and glucagon in a case of calcium channel blocker overdose. Ann Emerg Med. 1993 Jul. 22(7):1225-8. [QxMD ... Amrinone as an antidote in experimental verapamil overdose. Acad Emerg Med. 1996 Aug. 3(8):762-7. [QxMD MEDLINE Link]. ... Tuncok Y, Apaydin S, Kalkan S, Ates M, Guven H. The effects of amrinone and glucagon on verapamil-induced cardiovascular ...
Use of amrinone and glucagon in a case of calcium channel blocker overdose. Ann Emerg Med. 1993 Jul. 22(7):1225-8. [QxMD ... Amrinone as an antidote in experimental verapamil overdose. Acad Emerg Med. 1996 Aug. 3(8):762-7. [QxMD MEDLINE Link]. ... Tuncok Y, Apaydin S, Kalkan S, Ates M, Guven H. The effects of amrinone and glucagon on verapamil-induced cardiovascular ...
Shuster, E., Greenwald, E. F., Marantz, P. R., Bengershom, E., Shalev, R., Shalev, O., Kaye, T., Bank, W. J., Hurwich, B. J., Lang, D. M., Ogilvie, J. W., Goldberg, E. S., Berger, R. L. & Angell, M., Mar 21 1991, In: New England Journal of Medicine. 324, 12, p. 845-847 3 p.. Research output: Contribution to journal › Letter › peer-review ...
  • MCI-154 increased the cyclic AMP levels only at 3 X 10(-4) M, whereas CI-914, of which chemical structure is similar to that of MCI-154, elevated definitely the cyclic AMP at the lower concentrations (10(-5) to 10(-4) M). Carbachol at a concentration known to decrease markedly the PIE of amrinone, milrinone and papaverine, did not affect the PIE of MCI-154. (aspetjournals.org)
  • Amrinone, milrinone and papaverine inhibited more potently the PDE activity than MCI-154. (aspetjournals.org)
  • These results suggest that the elevation of cyclic AMP levels is only partially involved in the PIE of MCI-154 in the canine right ventricular muscle, and that MCI-154 may have novel mechanisms of action different from those of amrinone, milrinone and CI-914 that are largely cyclic AMP-dependent. (aspetjournals.org)
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  • Amrinone is a positive inotropic agent and phosphodiesterase inhibitor used in the treatment of congestive Cardiac failure. (medicoinfo.org)