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A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
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The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
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One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
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A concept, developed in 1983 under the aegis of and supported by the National Library of Medicine under the name of Integrated Academic Information Management Systems, to provide professionals in academic health sciences centers and health sciences institutions with convenient access to an integrated and comprehensive network of knowledge. It addresses a wide cross-section of users from administrators and faculty to students and clinicians and has applications to planning, clinical and managerial decision-making, teaching, and research. It provides access to various types of clinical, management, educational, etc., databases, as well as to research and bibliographic databases. In August 1992 the name was changed from Integrated Academic Information Management Systems to Integrated Advanced Information Management Systems to reflect use beyond the academic milieu.
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Effects of single administration of a phosphodiesterase III inhibitor during cardiopulmonary bypass: comparison of milrinone and amrinone. (1/66)
The effects of phosphodiesterase III (PDE III) inhibitors administered after aortic declamping during cardiopulmonary bypass (CPB) for open heart surgery were investigated. Ten patients (group M) were administered milrinone (50 microg/kg) after aortic declamping during CPB, 10 patients were administered amrinone (1 mg/kg) at the same time during their surgery (group A), and 10 patients served as controls with no drug administered (group C). Soon after bolus infusion of the PDE III inhibitor, perfusion pressure dropped significantly in groups M and A. However, after release of CPB and at the end of surgery, there was no difference in aortic pressure between the 3 groups. There were also no differences between the groups in heart rate, pulmonary artery pressure, and pulmonary capillary wedge pressure. After weaning from CPB, the cardiac index was high and systemic vascular resistance index was low in groups M and A. There were no significant differences in the need for additional catecholamines and time for rewarming between groups. No adverse reactions were observed. A single administration of a PDE III inhibitor during CPB was useful for post-CPB management of patients undergoing open heart surgery. Amrinone reduced perfusion pressures more than milrinone, but cardiac indices and aortic pressures after weaning from CPB showed no differences between group M and group A patients. (+info)Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1. (2/66)
The effects of amrinone, a selective phosphodiesterase III inhibitor, on liver ischaemia reperfusion injury have not yet been clarified. Forty-five patients with hepatocellular carcinoma who underwent partial liver resection using Pringle's manoeuvre were studied. Patients were divided into three groups: those given amrinone, those given prostaglandin E1 (PGE1) and those not treated (controls). An indocyanine green (ICG) clearance test was performed before the operation and three times during surgery: just before induction of liver ischaemia, just after liver resection and 60 min after reperfusion. Blood lactate and base excess were measured at the same times. Systolic and diastolic arterial pressure, heart rate, cardiac index and oesophageal temperature were monitored. Aminotransferase levels were recorded the day before surgery, 1 h after operation and on the first and third postoperative days. These data were compared between groups. The ICG elimination rate, lactate and base excess in the amrinone group differed significantly from those in controls during the observation period (P = 0.03, P = 0.04 and P = 0.03, respectively). The differences between the PGE1 and control groups were not significant. There were no significant differences between the groups in perioperative vital signs, cardiac index or postoperative aminotransferase. Amrinone enhanced intraoperative ICG elimination in cirrhotic patients who underwent liver resection. (+info)Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro. (3/66)
An experimental study was done to examine a potential role of phosphodiesterase (PDE) inhibitors in the treatment of diabetic erectile dysfunction. Relaxant effect of specific PDE inhibitors were measured in strips of corpus cavernosum smooth muscle taken from control and diabetic groups. Diabetes mellitus was induced in New Zealand white rabbits using alloxan. Penises excised from diabetic rabbits 8 weeks after the induction of diabetes mellitus. In the organ bath strips from control and diabetic rabbit corpus cavernosum were precontracted and increasing doses of several PDE inhibitors were added. In the precontracted rabbit cavernous tissue, sulmazole and zaprinast specific PDE V inhibitors were equally potent and efficacious in vitro but amrinone, a specific PDE III inhibitor, exhibits low relaxant effects. All PDE inhibitors tested showed a similar relaxation effect on corpus cavernosum smooth muscle from control and 8-week diabetic rabbits. The present study provides the possibility of using selective PDE III and V inhibitors in the treatment of diabetic impotence. (+info)Lack of role for nitric oxide in cholinergic modulation of myocardial contractility in vivo. (4/66)
Despite intensive investigation, the role of nitric oxide (NO) in cholinergic modulation of myocardial contractility remains unresolved. The left anterior descending coronary artery of 34 anesthetized, open-chest dogs was perfused via an extracorporeal circuit. Segmental shortening (SS) was measured with ultrasonic crystals and coronary blood flow (CBF) was measured with an ultrasonic flow transducer. An intracoronary infusion of ACh (20 microg/min) was performed, with CBF held constant, under baseline and during dobutamine, CaCl(2), or amrinone at doses increasing SS by approximately 50% (10 microg/min, 15 mg/min, and 300 microg/min ic, respectively). ACh-induced responses during dobutamine were also assessed following treatment with the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME; 300 microg/min ic for 15 min). The effects of sodium nitroprusside (SNP; 80 microg/min ic), an exogenous NO donor, bradykinin (2.5 microg/min ic), a nonmuscarinic releaser of endothelial NO, and bilateral vagal stimulation (before and after L-NAME) were evaluated during dobutamine. ACh had no effect on SS under baseline or during CaCl(2), but it decreased SS during dobutamine or amrinone (-23 +/- 4% and -30 +/- 5%, respectively). Vagal stimulation also reduced SS during dobutamine. L-NAME did not alter the ACh- or vagal-induced decreases in SS during dobutamine. Neither SNP nor bradykinin affected SS during dobutamine. In conclusion, ACh and vagal stimulation have a negative inotropic effect during stimulation of the beta-adrenergic receptors that is independent of NO. The persistence of this effect during amrinone suggests that a mechanism downstream from adenylate cyclase is involved. (+info)In contrast to forskolin and 3-isobutyl-1-methylxanthine, amrinone stimulates the cardiac voltage-sensitive release mechanism without increasing calcium-induced calcium release. (5/66)
The objective of this study was to determine whether the voltage-sensitive release mechanism (VSRM) can be stimulated independently from Ca(2+)-induced Ca(2+) release (CICR) by drugs that elevate intracellular cAMP. Contractions were measured in voltage-clamped guinea pig ventricular myocytes at 37 degrees C. Na(+) current was blocked. We compared effects of agents that elevate cAMP through activation of adenylyl cyclase (1 microM forskolin), nonspecific inhibition of phosphodiesterases (PDEs) [100 microM 3-isobutyl-1-methylxanthine (IBMX)], and selective inhibition of PDE III (100-500 microM amrinone) on contractions initiated by the VSRM and CICR. Forskolin and IBMX significantly increased peak Ca(2+) current and CICR. In addition, these agents also markedly increased contractions elicited by test steps from -65 to -40 mV, which activate the VSRM. However, because these steps also induced inward current in the presence of forskolin or IBMX, CICR could not be excluded. In contrast, amrinone caused a large, concentration-dependent increase in VSRM contractions but had no effect on CICR contractions or Ca(2+) current. Sarcoplasmic reticulum Ca(2+), assessed by rapid application of caffeine (10 mM), was increased only modestly by all three drugs. Normalization of contractions to caffeine contractures indicated that amrinone increased fractional release by the VSRM, but not CICR. Forskolin and IBMX increased fractional release elicited by steps to -40 mV. Increases in CICR induced by forskolin and IBMX were proportional to caffeine contractures. Thus, positive inotropic effects of cAMP on VSRM contractions may be compartmentalized separately from effects on Ca(2+) current and CICR. (+info)Amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures. (6/66)
We investigated the effects of i.v. amrinone on intraoperative changes of core temperature during deliberate mild hypothermia for neurosurgery. The patients in a control group (n=10) did not receive amrinone and patients in the amrinone group (n=10) received amrinone 5 microg kg(-1) min(-1) after a loading dose of 1.0 mg kg(-1). Anaesthesia was maintained with nitrous oxide in oxygen, propofol and fentanyl. After the induction of anaesthesia, patients were cooled and tympanic membrane temperature was maintained at 34.5 degrees C. After completion of the main surgical procedures, patients were rewarmed in the operating room. Tympanic membrane temperatures between 30 and 90 min after cooling were significantly lower in the amrinone group than in the control group. During cooling, the times taken to cool to 35 degrees C and to the lowest temperature were significantly shorter in the amrinone group than in the control group. These results suggest that i.v. amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures. (+info)High-dose amrinone is required to accelerate rewarming from deliberate mild intraoperative hypothermia for neurosurgical procedures. (7/66)
BACKGROUND: Since the time available to provide the cooling and rewarming is limited during deliberate mild hypothermia, the technique to accelerate the cooling and rewarming rate of core temperature has been studied. Amrinone has been reported to accelerate the cooling rate but not the rewarming rate of core temperature during deliberate mild hypothermia. The failure of amrinone effect on the rewarming rate might be due to an insufficient dose of amrinone during hypothermic conditions. The authors therefore tested whether higher doses of amrinone can accelerate the rewarming rate of core temperature during deliberate mild hypothermia for neurosurgery. METHODS: After institutional approval and informed consent, 30 patients were randomly assigned to one of three groups. Patients in the control group (n = 10) did not receive amrinone; patients in the AMR 15 group (n = 10) received 15 microg x kg(-1) x min(-1) amrinone with a 1.0-mg/kg loading dose of amrinone at the beginning of cooling; and patients in the ReAMR group (n = 10) received 5 microg x kg(-1) x min(-1) amrinone with 1.0-mg/kg loading and reloading doses of amrinone at the beginning of cooling and rewarming, respectively. Administration of amrinone was started just after the induction of cooling and continued until the end of anesthesia. Anesthesia was maintained with nitrous oxide in oxygen, propofol, and fentanyl. After induction of anesthesia, patients were cooled, and tympanic membrane temperature was maintained at 34.5 degrees C. After completion of the main surgical procedures, patients were actively rewarmed and extubated in the operating room. RESULTS: The cooling and rewarming rates of core temperature were both significantly faster in both amrinone groups than in the control group. During the cooling and rewarming periods, forearm minus fingertip temperature gradient was significantly smaller in both amrinone groups than in the control group. During the rewarming period, heart rate and mean arterial pressure in the AMR 15 group were significantly faster and lower, respectively, than in the control group. Systemic vascular resistance in the AMR 15 group was smaller than in the control group throughout the study; on the other hand, only the value after the start of rewarming in the ReAMR group was smaller than in the control group. CONCLUSIONS: Amrinone at an infusion rate of 15 or 5 microg x kg(-1) x min(-1) with a reloading at the beginning of rewarming accelerated the rewarming rate of core temperature during deliberate mild hypothermia. This suggests that high-dose amrinone is required to accelerate rewarming from deliberate mild intraoperative hypothermia for neurosurgical procedures. (+info)Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. (8/66)
BACKGROUND: Mounting evidence links systemic and local inflammatory cytokine production to myocardial dysfunction and injury occurring during ischemia-reperfusion, cardiopulmonary bypass, and heart failure. Phosphodiesterase inhibitors (PDEIs), used frequently in these states, can modulate inflammatory signaling. The mechanisms for these effects are unclear. We therefore examined the effects of 2 commonly used PDEIs, amrinone and milrinone, on cardiac cell inflammatory responses. METHODS AND RESULTS: Primary rat cardiomyocyte cultures were treated with endotoxin (LPS) or tumor necrosis factor-alpha (TNF-alpha), alone or in the presence of clinically relevant concentrations of amrinone or milrinone. Regulation of nuclear factor-kappa B (NFkappaB), nitric oxide synthase and cyclooxygenase isoforms, and cytokine production were assessed by electrophoretic mobility shift assays, Western immunoblotting, and enzyme-linked immunoassays, respectively. Both LPS and TNF-alpha induced significant NFkappaB activation, cyclooxygenase-2 (COX-2) expression, and inducible NO synthase (iNOS) and cytokine production; with the exception of COX-2 expression, all were significantly reduced by amrinone, beginning at concentrations of 10 to 50 micro mol/L. In contrast, milrinone increased nuclear NFkappaB translocation, iNOS and COX-2 expression, and cardiomyocyte production of interleukin-1beta. Cell-permeable cAMP increased inflammatory gene expression, whereas cell-permeable cGMP had no effect, indicating that the effects of amrinone were not due to phosphodiesterase inhibition. Similar results were seen in macrophages and coronary vascular endothelial cells. CONCLUSIONS: Both amrinone and milrinone have significant effects on cardiac inflammatory signaling. Overall, amrinone reduces activation of the key transcription factor NFkappaB and limits the production of pro-inflammatory cytokines, whereas milrinone does not. (+info)
Intravenous Amrinone: An Advance or a Wrong Step? | Annals of Internal Medicine | American College of Physicians
The effects of amrinone on platelet count, survival and function in patients with congestive cardiac failure.
Amrinone - Wikipedia
The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury | BMC Infectious Diseases | Full Text
Anthony DiLemme - How To Fight Cardiac Depression
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Bupivacaine-induced myocardial depression and pulmonary edema:...
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Comparison of early and late intravenous infusion of milrinone in children upto 1 year undergoing cardiac surgery.
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Milrinone Injection Supplier, Milrinone Injection Exporter, Manufacturer
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Milrinone
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Comparison of ancillary ligand effects between 2,2′-bipyridine and 2-(2′-pyridyl)phenyl in the linkage and bridging isomerism...
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AMRINONE LACTATE 30. ANALGIN 31. ANDROGENIC ANABOLIC, OESTROGENIC & PROGESTATIONAL SUBSTANCES 32. ANTIBIOTICS ...
Amrinon - Википедија
Amrinone. Molimo Vas, obratite pažnju na važno upozorenje. u vezi sa temama iz oblasti medicine (zdravlja). ...
PDE3 inhibitor
Amrinone, milrinone and enoximone are used clinically for short-term treatment of cardiac failure in the presence of ... Approved PDE3 inhibitors include the following: amrinone cilostazol milrinone enoximone pimobendan (approved for use in dogs) ...
Antihypotensive agent
Fludrocortisone Positive inotropic agents Cardiac glycosides Strophantin K Convallatoxin Digoxin PDE3 inhibitors Amrinone ...
List of MeSH codes (D03)
... amrinone MeSH D03.383.725.050.085.543 - milrinone MeSH D03.383.725.050.440 - methapyrilene MeSH D03.383.725.050.610 - ...
ATC code C01
... combinations C01CE01 Amrinone C01CE02 Milrinone C01CE03 Enoximone C01CE04 Bucladesine QC01CE90 Pimobendane C01CX06 ...
List of drugs: Am
Amrinone amrinone (INN) amrubicin (INN) amsacrine (INN) amsilarotene (USAN) amtolmetin guacil (INN) amustaline dihydrochloride ...
Inotrope
Angiotensin II Eicosanoids Prostaglandins Phosphodiesterase inhibitors Enoximone Milrinone Amrinone Theophylline Glucagon ...
Peter Wilmshurst
... approached The Guardian newspaper with a substantial dossier detailing alleged misconduct in the development of Amrinone, a ...
Amrinone
Both inotropic and lusitropic effects are the reason why amrinone is used to treat heart failure. Amrinone decreases the ... There is a net decrease in myocardial wall tension, and O2 consumption when using amrinone. Amrinone also has beneficial ... Amrinone is the INN, while inamrinone is the United States Adopted Name, which was adopted in 2000 in an attempt to avoid ... Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may ...
Roflumilast
... (trade names Daxas, Daliresp) is a drug that acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). It has anti-inflammatory effects and is used as an orally administered drug for the treatment of inflammatory conditions of the lungs such as chronic obstructive pulmonary disease (COPD).[5][6][7][8] In June 2010, it was approved in the EU for severe COPD associated with chronic bronchitis.[9] In March 2011, it gained FDA approval in the US for reducing COPD exacerbations.[10] ...
T-0156
HCl): InChI=1S/C31H29N5O7.ClH/c1-18-13-19(7-11-32-18)16-36-27(31(38)42-5)25(20-14-22(39-2)28(41-4)23(15-20)40-3)21-8-12-35-29(26(21)30(36)37)43-17-24-33-9-6-10-34-24;/h6-15H,16-17H2,1-5H3; ...
Paraxanthine
... is not produced by plants[citation needed] and is only observed in nature as a metabolite of caffeine in animals. Paraxanthine is also a natural metabolite of caffeine in some species of bacteria.[1] After intake, roughly 84% of caffeine is demethylated at the 3-position to yield paraxanthine, making it the chief metabolite of caffeine in the body.[2] Paraxanthine is also a major metabolite of caffeine in humans and other animals, such as mice.[3] Shortly after ingestion, caffeine is metabolized into paraxanthine by hepatic cytochrome P450,[4] which removes a methyl group from the N3 position of caffeine.[5] After formation, paraxanthine can be broken down to 7-methylxanthine by demethylation of the N1 position,[6] which is subsequently demethylated into xanthine or oxidized by CYP2A6 and CYP1A2 into 1,7-dimethylaric acid.[5] In another pathway, paraxanthine is broken down into 5-acetylamino-6-formylamino-3-methyluracil through N-acetyl-transferase 2, which is then broken down into ...
CC-1088
Molostvov G, Morris A, Rose P, Basu S, Muller G (February 2004). "The effects of selective cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and apoptosis in myeloma and endothelial cell co-cultures". British Journal of Haematology. 124 (3): 366-75. doi:10.1046/j.1365-2141.2003.04777.x. PMID 14717786 ...
Theophylline
... has been shown to inhibit TGF-beta-mediated conversion of pulmonary fibroblasts into myofibroblasts in COPD and asthma via cAMP-PKA pathway and suppresses COL1 mRNA, which codes for the protein collagen.[24] It has been shown that theophylline may reverse the clinical observations of steroid insensitivity in patients with COPD and asthmatics who are active smokers (a condition resulting in oxidative stress) via a distinctly separate mechanism. Theophylline in vitro can restore the reduced HDAC (histone deacetylase) activity that is induced by oxidative stress (i.e., in smokers), returning steroid responsiveness toward normal.[25] Furthermore, theophylline has been shown to directly activate HDAC2.[25] (Corticosteroids switch off the inflammatory response by blocking the expression of inflammatory mediators through deacetylation of histones, an effect mediated via histone deacetylase-2 (HDAC2). Once deacetylated, DNA is repackaged so that the promoter regions of inflammatory genes ...
Glaucine
Reports of recreational use of glaucine have recently been published, and effects include dissociative-type symptoms; feeling detached and 'in another world', as well as nausea, vomiting and dilated pupils. These reports mirror those about the effects of clinical use, which state dissociative-type symptoms as well as lethargy, fatigue, hallucinations.[8][9] Investigation of side effects in a clinical setting also reports that the hallucinatory effects manifest as bright and colorful visualizations. They also report that patients perceive their environments clearly yet feel detached from it; "the patient sees and understands everything and is oriented well enough, but cannot take a clear and adequate action".[8]. One particular report of recreational use gone awry described the form of distribution as tablets being marketed as a 1-benzylpiperazine (BZP)-free "herbal high" which the patient referred to as "head candy".[9]. ...
Vardenafil
The common, adverse drug reactions (side effects) are the same as with other PDE5 inhibitors. The frequent vardenafil-specific side-effect is nausea; the infrequent side effects are abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial edema, hypotension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, and priapism. One possibly serious, but rare, side effect with vardenafil is heart attack. Also, in rare cases, vardenafil use may cause priapism, a very painful emergency condition that can cause impotence if left untreated.[4] On 18 October 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness (sudden hearing loss) would be added to the drug labels of vardenafil, and other PDE5 inhibitors.[5] ...
Enprofylline
Lunell E, Svedmyr N, Andersson KE, Persson CG (1982). "Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease". European Journal of Clinical Pharmacology. 22 (5): 395-402. doi:10.1007/bf00542541. PMID 6288396 ...
Theobromine
Animals that metabolize theobromine (found in chocolate) more slowly, such as dogs,[26] can succumb to theobromine poisoning from as little as 50 grams (1.8 oz) of milk chocolate for a smaller dog and 400 grams (14 oz), or around nine 44-gram (1.55 oz) small milk chocolate bars, for an average-sized dog. The concentration of theobromine in dark chocolates (approximately 10 g/kg (0.16 oz/lb)) is up to 10 times that of milk chocolate (1 to 5 g/kg (0.016 to 0.080 oz/lb)) - meaning dark chocolate is far more toxic to dogs per unit weight or volume than milk chocolate. The same risk is reported for cats as well,[27] although cats are less likely to ingest sweet food, with most cats having no sweet taste receptors.[28] Complications include digestive issues, dehydration, excitability, and a slow heart rate. Later stages of theobromine poisoning include epileptic-like seizures and death. If caught early on, theobromine poisoning is treatable.[29] Although not common, the effects of theobromine ...
Tadalafil
The FDA's approval of sildenafil in 1998[16] was a ground-breaking commercial event for the treatment of ED, with sales exceeding US$1 billion. Subsequently, the FDA approved vardenafil in 2003,[17] and tadalafil in 2003. It initially was developed by the biotechnology company ICOS, and then again developed and marketed worldwide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Tadalafil was approved in 2009 in the United States for the treatment of pulmonary arterial hypertension[18] and is under regulatory review in other regions for this condition. In late November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of $150 million. Tadalafil was discovered by Glaxo Wellcome (now GlaxoSmithKline) under a partnership between Glaxo and ICOS to develop new drugs that began in August 1991.[19][20] In 1993, the Bothell, Washington biotechnology ...
PDE11
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Vinpocetine
Kindling models in rats has shown vinpocetine to exhibit anticonvulsant properties. The most pronounced anticonvulsant effects were observed in Pentylenetetrazole (PTZ)-kindled rats although there was also an effect on amygdala-kindled and neocortically-kindled rats.[8] Vinpocetine has also been shown to abolish [3H]Glu release after in vivo exposure to 4-aminopyridine (4-AP) which suggests an important mechanism for vinpocetine anticonvulsant activity.[9] Vinpocetine has been investigated in animal models as a potential anti-inflammatory agent.[10] [11] Vinpocetine inhibits the up-regulation of NF-κB by TNFα in various cell tests. Reverse transcription polymerase chain reaction also shows that it reduced the TNFα-induced expression of the mRNA of proinflammatory molecules such as interleukin-1 beta, monocyte chemoattractant protein-1 (MCP-1), and vascular cell adhesion molecule-1 (VCAM-1). In mice, vinpocetine reduced lipopolysaccharide inoculation induced polymorphonuclear neutrophil ...
Amrinone - Wikipedia
Both inotropic and lusitropic effects are the reason why amrinone is used to treat heart failure. Amrinone decreases the ... There is a net decrease in myocardial wall tension, and O2 consumption when using amrinone. Amrinone also has beneficial ... Amrinone is the INN, while inamrinone is the United States Adopted Name, which was adopted in 2000 in an attempt to avoid ... Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may ...
Amrinone - definition of amrinone by The Free Dictionary
amrinone synonyms, amrinone pronunciation, amrinone translation, English dictionary definition of amrinone. Noun 1. amrinone - ... amrinone. Also found in: Thesaurus, Medical, Wikipedia.. Related to amrinone: Inocor. ThesaurusAntonymsRelated WordsSynonyms ... Amrinone - definition of amrinone by The Free Dictionary https://www.thefreedictionary.com/amrinone ... amrinone - a drug (trade name Inocor) used intravenously in heart failure; increases strength of contraction of myocardium. ...
Amrinone/Inocor : Wheeless' Textbook of Orthopaedics
Clinical applications of amrinone. | Sigma-Aldrich
In these patients, amrinones ability to augment cardiac performance without increasing heart rate or myocardial oxygen ... A bipyridine derivative, amrinone is a noncatecholamine, nonglycoside alternative in the treatment of perioperative myocardial ... A type-3 phosphodiesterase enzyme inhibitor, amrinone combines positive inotropic support with systemic and pulmonary ...
Amrinone - DrugBank
Amrinone (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart ... Amrinone. Accession Number. DB01427. Type. Small Molecule. Groups. Approved. Description. Amrinone (or inamrinone) is a type 3 ... Amrinone. ATC Codes. C01CE01 - Amrinone*C01CE - Phosphodiesterase inhibitors. *C01C - CARDIAC STIMULANTS EXCL. CARDIAC ... Amrinone lactate. I229274Y5B. 75898-90-7. DOSIONJFGDSKCQ-UHFFFAOYSA-N. Prescription Products. Name. Dosage. Strength. Route. ...
Amrinone lactate - Biology-Online Dictionary
Intravenous Amrinone: An Advance or a Wrong Step? | Annals of Internal Medicine | American College of Physicians
Amrinone is advertised as a "major advance" in inotropic therapy because of its alleged advantages of more sustained action ... Intravenous Amrinone: An Advance or a Wrong Step?. Ann Intern Med. 1985;102:399-400. doi: 10.7326/0003-4819-102-3-399 ... Amrinone is a nonglycosidic, non-catecholamine-dependent, inotropic vasodilator agent that has recently been made available for ... Intravenous Amrinone: An Advance or a Wrong Step? JOSEPH A. FRANCIOSA, M.D. ...
Tachyphylaxis with Amrinone Therapy: Association with Sequestration and Down-Regulation of Lymphocyte Beta-Adrenergic Receptors...
Tachyphylaxis with Amrinone Therapy: Association with Sequestration and Down-Regulation of Lymphocyte Beta-Adrenergic Receptors ... Tachyphylaxis with Amrinone Therapy: Association with Sequestration and Down-Regulation of Lymphocyte Beta-Adrenergic Receptors ... Interventions: A bolus of intravenous amrinone followed by a continuous infusion at 10 µg/kg · min for 72 hours. ... Study Objective: To determine whether intravenous therapy with amrinone changes number, location or function of the β- ...
Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle. | Journal...
The cyclic GMP level determined simultaneously was not changed by amrinone. The amrinone-induced increases in force of ... Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle.. M Endoh, S ... Amrinone shortened the time required for relaxation of a single contraction to the same extent as isoproterenol and cyclic AMP ... Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle.. M Endoh, S ...
High-dose Amrinone Is Required to Accelerate Rewarming from Deliberate Mild Intraoperative Hypothermia for Neurosurgical...
AMR 15 (open circle) = a group of patients who re-ceived 15 μg · kg−1· min−1amrinone with a 1.0-mg/kg loading dose of amrinone ... AMR 15 (open circle) = a group of patients who re-ceived 15 μg · kg−1· min−1amrinone with a 1.0-mg/kg loading dose of amrinone ... AMR 15 (open circle) = a group of patients who re-ceived 15 μg · kg−1· min−1amrinone with a 1.0-mg/kg loading dose of amrinone ... AMR 15 (open circle) = a group of patients who re-ceived 15 μg · kg−1· min−1amrinone with a 1.0-mg/kg loading dose of amrinone ...
Amrinone Lactate: Medgend
AMRINONE - Watsons Health
DRUG INTERACTIONS. Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.. ...
Acute effects of amrinone on regional myocardial and systemic blood flow distribution in the dog<...
Acute effects of amrinone on regional myocardial and systemic blood flow distribution in the dog. / Einzig, S.; Rao, G. H.R.; ... Einzig, S., Rao, G. H. R., Pierpont, M. E. M., & White, J. G. (1982). Acute effects of amrinone on regional myocardial and ... Acute effects of amrinone on regional myocardial and systemic blood flow distribution in the dog. Canadian Journal of ... Einzig, S. ; Rao, G. H.R. ; Pierpont, Mary Ella M ; White, J. G. / Acute effects of amrinone on regional myocardial and ...
Part 6: Advanced Cardiovascular Life Support | Circulation
Amrinone and Milrinone. Amrinone and milrinone are phosphodiesterase III inhibitors that have inotropic and vasodilatory ... Amrinone is administered as a dose of 0.75 mg/kg given initially over 2 to 3 minutes, followed by an infusion of 5 to 15 μg/kg ... Amrinone has a more significant effect on preload than catecholamines, and the hemodynamic effects are similar to those of ... Like amrinone, milrinone has a relatively long plasma half-life, which makes dose titration more difficult. Milrinone may also ...
Growth factor expression and effects of amrinone in monocrotaline- induced pulmonary hypertension in rats<...
Growth factor expression and effects of amrinone in monocrotaline- induced pulmonary hypertension in rats. / Burch, Grant H.; ... Burch, GH, Jensen, LR, Pappas, J, Hammond, EH, Banner, W & Shaddy, RE 1996, Growth factor expression and effects of amrinone ... Fingerprint Dive into the research topics of Growth factor expression and effects of amrinone in monocrotaline- induced ... Growth factor expression and effects of amrinone in monocrotaline- induced pulmonary hypertension in rats. Biochemical and ...
PHARMACOKINETICS OF AMRINONE IN INFANTS | Anesthesiology | American Society of Anesthesiologists
PHARMACOKINETICS OF AMRINONE IN INFANTS S. Lawless, M.D. ; S. Lawless, M.D. ... High-dose Amrinone Is Required to Accelerate Rewarming from Deliberate Mild Intraoperative Hypothermia for Neurosurgical ... Amrinone Is Superior to Epinephrine in Reversing Bupivacaine-induced Cardiovascular Depression in Sevoflurane-anesthetized Dogs ... S. Lawless, G. Burckart, A. Thompson, R. Siewers; PHARMACOKINETICS OF AMRINONE IN INFANTS. Anesthesiology 1987; 67:A145 doi: ...
Inocor (amrinone lactate) | Critical Care Nurse | American Association of Critical-Care Nurses
Schedule H - Wikipedia
Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane Anesthesia in Dogs | Anesthesiology | ASA...
Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane Anesthesia in Dogs. Anesthesiology 6 1987, Vol. ... Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane Anesthesia in Dogs ... Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane Anesthesia in Dogs ... Virve H. M. Makela, Patricia A. Kapur; Amrinone and Verapamil-propranolol Induced Cardiac Depression during Isoflurane ...
The effects of amrinone on platelet count, survival and function in patients with congestive cardiac failure.
February 1987 - Volume 9 - Issue 2 : Journal of Cardiovascular Pharmacology
Clinical operational and gainsharing information management system - GOODROE JOANE
Patente US6987129 - Compounds and methods for the treatment of urogenital disorders - Google Patentes
The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial cystitis, nonspecific urethriris (i.e., nonspecific pain and/or burning of the urinary tract) and sexual dysfunctions, such as, for example, female sexual arousal disorders and female sexual orgasmic disorders, using a variety of compounds, including, but not limited to, NO donors, calcium channel blockers, cholinergic modulators, α-adrenergic receptor antagonists, β-adrenergic receptor agonists, phosphodiesterase inhibitors, cAMP-dependent protein kinase activators (e.g., cAMP mimetics), superoxide scavengers, potassium channel activators, estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, antidiarrheal agents, HMG-CoA reductase inhibitors, smooth muscle relaxants, adenosine receptor modulators, adenylyl cyclase activators, endothelin receptor antagonists,
March-April 1984 - Volume 6 - Issue 2 : Journal of Cardiovascular Pharmacology
Phosphodiesterase (PDE) Inhibitors
BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVisions products are currently being sold in more than 60 countries worldwide.
Current Drug Price List - List of Generic Names starting with A
Cardiology - Drugs| Medindia
Preparing for Pediatric Emergencies: Drugs to Consider | FROM THE AMERICAN ACADEMY OF PEDIATRICS | Pediatrics
Beneficial effects of amrinone-hydralazine combination on resting hemodynamics and exercise capacity in patients with severe...
When compared with amrinone alone (100 mg) or hydralazine alone (75-100 mg), the increase in stroke volume index and the ... When compared with amrinone alone (100 mg) or hydralazine alone (75-100 mg), the increase in stroke volume index and the ... When compared with amrinone alone (100 mg) or hydralazine alone (75-100 mg), the increase in stroke volume index and the ... When compared with amrinone alone (100 mg) or hydralazine alone (75-100 mg), the increase in stroke volume index and the ...
Protection of amrinone against lung injury induced by ischemia/reperfusion in rats | Chinese Journal of Contemporary...
Amrinone , Animals , Interleukin-1beta , Blood , Interleukin-8 , Blood , Lung , Male , Malondialdehyde , Phosphodiesterase ... p,,b,OBJECTIVE,/b,To investigate the protective effect of amrinone against experimental lung ischemia /reperfusion (I/R) injury ... The rats of the AMR group received amrinone (10 mg/kg) intravenously 30 minutes before ischemia and 5 minutes before ... Protection of amrinone against lung injury induced by ischemia/reperfusion in rats / 中国当代儿科杂志 ...
MilrinoneInocorBolusCongestive heart fIntravenous AmrinoneInotropic effectInamrinoneAction as amrinonePlasma amrinoneHemodynamic effectsRegional myocardialCardiacInfusionInhibitorIsoproterenolThrombocytopeniaEpinephrineVascular smoothMyocardial dysfunctionDopamineConcomitantlyEffectsRatsVasodilatorVasodilationArterialInvestigateHeart failureConcentrationCardiovascularTherapyEffectSurvivalStudyCalcium
Milrinone7
- Brutsaert, "Positive inotropic and vasodilating effects of amrinone and milrinone in isolated canine heart," Journal of Cardiovascular Pharmacology, vol. (thefreedictionary.com)
- Amrinone, milrinone and enoximone are used clinically for short-term treatment of cardiac failure in the presence of cardiogenic shock. (wikipedia.org)
- Approved PDE3 inhibitors include the following: amrinone cilostazol milrinone enoximone pimobendan (approved for use in dogs) PDE3 inhibitors are a type of phosphodiesterase inhibitors. (wikipedia.org)
- Phosphodiesterase-III Inhibitors Amrinone and Milrinone on Epilepsy and Cardiovascular Activities. (ebscohost.com)
- The article discusses the utilization of Phosphodiesterase (PDE)-III inhibitors like Amrinone and Milrinone in epilepsy and cardiovascular disorders, and examines the role of cyclic PDE-III in causing seizures. (ebscohost.com)
- Amrinone or milrinone may be indicated. (pacoimabeautiful.org)
- Milrinone is a derivative of amrinone and has 20-30 times the ionotropic potency of amrinone. (bioportfolio.com)
Inocor1
- Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. (wikipedia.org)
Bolus5
- Continuous infusion of amrinone after a bolus dose supported the heart beat during the surgery. (thefreedictionary.com)
- A bolus of intravenous amrinone followed by a continuous infusion at 10 µg/kg · min for 72 hours. (annals.org)
- The effect of bolus intravenous injections of amrinone (1-2 mg/kg) on abdominal organ, central nervous system, and myocardial blood flow distribution was examined in 15 anesthetized dogs. (umn.edu)
- These results suggest that vascular responsiveness to intravenous amrinone is not uniform in different circulatory beds and that relative subendocardial underperfusion of the left ventricular myocardium occurs following bolus intravenous amrinone injections in the dog. (umn.edu)
- Amrinone was given bolus (0.75 mg/kg) and infusion (10 microgram/ kg/min) was begun instead of ID at the release of aortic cross-clamp. (bvsalud.org)
Congestive heart f4
- Amrinone also has beneficial effects during diastole in the left ventricle including relaxation, compliance and filling in patients with congestive heart failure. (wikipedia.org)
- The effects of combined administration of low-dose amrinone (100 mg) and hydralazine (75-100 mg) on resting hemodynamics and exercise capacity were studied in nine patients with severe congestive heart failure. (elsevier.com)
- Thus, the hemodynamic effects of low-dose amrinone can be amplified by simultaneous administration of a vasodilator such as hydralazine in patients with severe congestive heart failure. (elsevier.com)
- Amrinone in severe congestive heart failure: another look at an intriguing new cardioactive drug. (aspetjournals.org)
Intravenous Amrinone1
- Intravenous Amrinone: An Advance or a Wrong Step? (annals.org)
Inotropic effect7
- The positive inotropic effect of amrinone is mediated by the selective enhancement of high gain CICR which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways. (wikipedia.org)
- Amrinone is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx like that caused by beta-agonists resulting in increased inotropic effect. (drugbank.ca)
- Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle. (aspetjournals.org)
- Experiments were carried out in the canine isolated right ventricular muscle in order to study the positive inotropic effect of amrinone in relation to the cyclic AMP and cyclic GMP metabolism. (aspetjournals.org)
- Amrinone inhibited the cyclic AMP phosphodiesterase purified from the canine right ventricular muscle and enhanced the positive inotropic effect of isoproterenol. (aspetjournals.org)
- These results altogether strongly suggest that the change in cyclic AMP metabolism is involved in the positive inotropic effect of amrinone on the canine ventricular muscle. (aspetjournals.org)
- Amrinone is a phosphodiesterase inhibitor that has an inotropic effect in addition to a vasodilatory effect because of its dual mechanism of action. (asahq.org)
Inamrinone2
- Amrinone (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. (drugbank.ca)
- After reconstitution, azathioprine is a yellow solution, similar to inamrinone (formerly amrinone). (ismp.org)
Action as amrinone2
- Trimethoprim has similar action as amrinone. (dsaj.org)
- When an action as amrinone. (bigsurlandtrust.org)
Plasma amrinone2
- The platelet count was significantly and variably reduced in all patients and the reduction was related to log plasma amrinone concentration. (ac.ke)
- One milliliter of blood was obtained every 30 min during drug administration to determine plasma amrinone and N-acetylamrinone concentrations. (aspetjournals.org)
Hemodynamic effects1
- The purpose of this investigation was to determine if N-acetylamrinone has direct hemodynamic effects independent of amrinone. (aspetjournals.org)
Regional myocardial1
- White, J. G. / Acute effects of amrinone on regional myocardial and systemic blood flow distribution in the dog . (umn.edu)
Cardiac7
- Amrinone decreases the pulmonary capillary wedge pressure while increasing cardiac output because it functions as an arterial vasodilator and increases venous capacitance while decreasing venous return. (wikipedia.org)
- An IV administration of amrinone has been shown to increase cardiac output (CO) and stroke volume (SV) while concurrently reducing the filling pressure of the left ventricle and decreasing the resistance in the peripheral vasculature. (wikipedia.org)
- Amrinone is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. (drugbank.ca)
- The effects of amrinone on platelet count, survival and function in patients with congestive cardiac failure. (ac.ke)
- In a prospective trial, the immediate and long-term haematological effects of amrinone were studied in sixteen patients with refractory cardiac failure. (ac.ke)
- Amrinone , having the ability to increase cardiac performance without increasing myocardial O2 consumption , is a valuable drug in postoperative management after cardiopulmonary bypass (CPB). (bvsalud.org)
- Amrinone versus conventional therapy in patients awaiting cardiac transplantation. (springer.com)
Infusion3
- High plasma concentrations of N-acetylamrinone, a primary metabolite of amrinone, are measured in some children during prolonged amrinone infusion. (aspetjournals.org)
- The mean amrinone plasma concentrations measured at 30 and 60 min during the infusion time in the group receiving amrinone were 8.8 +/- 1.1 and 6.9 +/- 0.7 micrograms/ml, respectively. (aspetjournals.org)
- These animals experienced a significant decrease in mean pulmonary artery pressure and pulmonary vascular resistance, compared with saline controls after a 30-min infusion of amrinone. (aspetjournals.org)
Inhibitor2
- A type-3 phosphodiesterase enzyme inhibitor, amrinone combines positive inotropic support with systemic and pulmonary vasodilation. (sigmaaldrich.com)
- Amrinone, a selective phosphodiesterase (PDE) III inhibitor, is a newly developed agent that possesses a combination of positive inotropic and vasodilating properties as a result of preventing the degradation of cAMP and it has recently been licensed for treatment of heart failure alone. (elsevier.com)
Isoproterenol3
- In an animal study, it was shown that glucagon was superior to isoproterenol and amrinone treatment (13). (thefreedictionary.com)
- This partial cardiovascular tolerance to amrinone was accompanied by a 126% increase in the plasma epinephrine, a 182% increase in norepinephrine, a 31% decrease in the number of β-adrenergic receptors on lymphocytes, and a 36% decrease in isoproterenol-stimulated cyclicadenosine monophosphate on lymphocytes. (annals.org)
- Amrinone shortened the time required for relaxation of a single contraction to the same extent as isoproterenol and cyclic AMP phosphodiesterase inhibitors such as 1-methyl-3-isobutylxanthine and papaverine. (aspetjournals.org)
Thrombocytopenia1
- Ansell J, McCue J, Tiarks C (1981) Amrinone-induced thrombocytopenia. (springer.com)
Epinephrine1
- Pharrnacologic action profile of Cratciegus extract in comparison to epinephrine, amrinone , mirinone and digoxin in the isolated perfnsed guinea pig heart. (thefreedictionary.com)
Vascular smooth1
- An increase in cAMP with the administration of amrinone in vascular smooth muscle produces vasodilation by facilitating calcium uptake by the sarcoplasmic reticulum (a special type of smooth ER) and decreasing the calcium available for contraction. (wikipedia.org)
Myocardial dysfunction1
- A bipyridine derivative, amrinone is a noncatecholamine, nonglycoside alternative in the treatment of perioperative myocardial dysfunction. (sigmaaldrich.com)
Dopamine3
- Because other agents, such as dopamine, dobutamine, and nitroprusside, are available and have actions similar to those of amrinone in patients with heart failure, the usefulness of this newer agent must be put in perspective. (annals.org)
- Amrinone is advertised as a "major advance" in inotropic therapy because of its alleged advantages of more sustained action than dopamine or dobutamine and reduction of myocardial oxygen demand. (annals.org)
- We performed this study to examine whether clonidine premedication could change the amount of dopamine used concomitantly with amrinone for management after CPB. (bvsalud.org)
Concomitantly2
- Twenty-four 26-day-old rats were randomized to receive either monocrotaline (≃3.6 mg/kg/d) or no monocrotaline and concomitantly to receive either amrinone (100 mg/kg/d) or no atarinone for 21 days. (elsevier.com)
- Clonidine , used as premedication , increases the need of catecholamine which is concomitantly administered with amrinone for weaning from CPB. (bvsalud.org)
Effects7
- Both inotropic and lusitropic effects are the reason why amrinone is used to treat heart failure. (wikipedia.org)
- Protective effects of different antioxidants and amrinone on vancomycin-induced nephrotoxicity. (thefreedictionary.com)
- Lungs were examined for immunohistochemical evidence of PDGF and bFGF, and hearts were examined for effects of pulmonary hypertension and amrinone. (elsevier.com)
- Amrinone has protections against lung I/R injury , possibly through its anti- oxidation effects and an inhibition of inflammation factors releasing. (bvsalud.org)
- The use of amrinone with a catecholamine is also important clinically because the cathecholamines support perfusion pressure and the combined use exerts synergistic or additive effects. (bvsalud.org)
- The ameliorating effects of amrinone were comparable to those of PGE 1 . (elsevier.com)
- Additive effects of dobutamine and amrinone on myocardial contractility and ventricular performance in patients with severe heart failure. (springer.com)
Rats3
- Twenty-four Sprague-Dawley rats were randomly divided into 3 groups (n=8 each) sham- operated group, I/R group, and amrinone -treated I/R group (AMR group). (bvsalud.org)
- The rats of the AMR group received amrinone (10 mg/kg) intravenously 30 minutes before ischemia and 5 minutes before reperfusion . (bvsalud.org)
- The improved survival area of random flaps in rats treated with amrinone was examined to assess therapeutic efficacy of this drug. (elsevier.com)
Vasodilator1
- Amrinone is a nonglycosidic, non-catecholamine-dependent, inotropic vasodilator agent that has recently been made available for intravenous use in patients with severe heart failure. (annals.org)
Vasodilation1
- We conclude that amrinone, but not N-acetylamrinone, causes pulmonary vasodilation in a porcine model of sepsis and that the parent drug is the sole active component in amrinone. (aspetjournals.org)
Arterial1
- bFGF staining was similar between groups (no monocrotaline 25%, monocrotaline 27%, monocrotaline and amrinone 22%), and the staining was confined to the arterial walls. (elsevier.com)
Investigate2
- The present study was therefore conducted to investigate whether higher-dose amrinone can accelerate the rewarming rate of core temperature by 0.3-0.4°C/h during deliberate mild hypothermia for neurosurgery. (asahq.org)
- To investigate the protective effect of amrinone against experimental lung ischemia / reperfusion (I/R) injury . (bvsalud.org)
Heart failure2
- Early studies in patients with heart failure showed that amrinone produced short-term hemodynamic improvement, but had limited long-term clinical benefit. (wikipedia.org)
- The results of this study suggest amrinone to be a potentially useful drug not only for treating heart failure but also for improving microcirculation in patients with vascular diseases and for postoperative care after reconstructive surgery. (elsevier.com)
Concentration1
- To obtain a higher amrinone concentration during the rewarming period, we employed two methods in this study. (asahq.org)
Cardiovascular1
- We suggest that these receptor changes also occur in cardiovascular tissues and may in part account for the tolerance to amrinone. (annals.org)
Therapy1
- To determine whether intravenous therapy with amrinone changes number, location or function of the β-adrenergic receptors on lymphocytes. (annals.org)
Effect2
- The reasons for failure of amrinone effect on the rewarming rate were unknown. (asahq.org)
- However, possible reasons could be that 5 μg · kg −1 · min −1 amrinone may be not enough to improve thermoregulatory vasoconstriction or that the inotropic or vasodilatory effect of amrinone might be modified under mild hypothermic condition. (asahq.org)
Survival1
- Microcirculatory blood flow and flap survival area were significantly increased in both amrinone- and PGE 1 - treated animals, compared to the saline-treated controls. (elsevier.com)
Study3
- 7 In our previous study, we investigated whether 5 μg · kg −1 · min −1 amrinone could affect temperature management during deliberate mild hypothermia for neurosurgery. (asahq.org)
- The phase I study of Win 40680 (Amrinone). (nii.ac.jp)
- The study found that in seizures induced by Isoniazid (INH), Amrinone at 0.5. (ebscohost.com)
Calcium1
- Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). (wikipedia.org)