Ampulla of Vater: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.Fallopian Tubes: A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Duodenoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the duodenum.Cholangiopancreatography, Endoscopic Retrograde: Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.Duodenoscopes: Endoscopes for examining the interior of the duodenum.Common Bile Duct Diseases: Diseases of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Anus, Imperforate: A congenital abnormality characterized by the persistence of the anal membrane, resulting in a thin membrane covering the normal ANAL CANAL. Imperforation is not always complete and is treated by surgery in infancy. This defect is often associated with NEURAL TUBE DEFECTS; MENTAL RETARDATION; and DOWN SYNDROME.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Jaundice: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.Biliary Tract Neoplasms: Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.Duodenum: The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.Sperm Transport: Passive or active movement of SPERMATOZOA from the testicular SEMINIFEROUS TUBULES through the male reproductive tract as well as within the female reproductive tract.Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Krukenberg Tumor: Mucocellular carcinoma of the ovary, usually metastatic from the gastrointestinal tract, characterized by areas of mucoid degeneration and the presence of signet-ring-like cells. It accounts for 30%-40% of metastatic cancers to the ovaries and possibly 1%-2% of all malignant ovarian tumors. The lesions may not be discovered until the primary disease is advanced, and most patients die of their disease within a year. In some cases, a primary tumor is not found. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1685)Gallstones: Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)Common Bile Duct: The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Duodenal Diseases: Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).Ovum Transport: Transport of the OVUM or fertilized ovum (ZYGOTE) from the mammalian oviduct (FALLOPIAN TUBES) to the site of EMBRYO IMPLANTATION in the UTERUS.Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Biliary Tract Surgical Procedures: Any surgical procedure performed on the biliary tract.Hair Cells, Ampulla: Sensory cells in the ampullary crest of each of the semicircular ducts, with their apical STEREOCILIA embedded in a wedge-shaped gelatinous cupula. These hair cells sense the movement of ENDOLYMPH resulting from angular acceleration of the head, and send signals via the VESTIBULAR NERVE to the brain to maintain balance.Endolymph: The lymph fluid found in the membranous labyrinth of the ear. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Semicircular Canals: Three long canals (anterior, posterior, and lateral) of the bony labyrinth. They are set at right angles to each other and are situated posterosuperior to the vestibule of the bony labyrinth (VESTIBULAR LABYRINTH). The semicircular canals have five openings into the vestibule with one shared by the anterior and the posterior canals. Within the canals are the SEMICIRCULAR DUCTS.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Equipment Reuse: Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Adenoma: A benign epithelial tumor with a glandular organization.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Complement C3: A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Uterine Cervical Dysplasia: Abnormal development of immature squamous EPITHELIAL CELLS of the UTERINE CERVIX, a term used to describe premalignant cytological changes in the cervical EPITHELIUM. These atypical cells do not penetrate the epithelial BASEMENT MEMBRANE.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Computers, Handheld: A type of MICROCOMPUTER, sometimes called a personal digital assistant, that is very small and portable and fitting in a hand. They are convenient to use in clinical and other field situations for quick data management. They usually require docking with MICROCOMPUTERS for updates.Bile Ducts, Extrahepatic: Passages external to the liver for the conveyance of bile. These include the COMMON BILE DUCT and the common hepatic duct (HEPATIC DUCT, COMMON).Frozen Sections: Thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome.Intraoperative Period: The period during a surgical operation.Intraoperative Care: Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.

Inhibitory innervation of cat sphincter of Oddi. (1/430)

1 Electrical stimulation with trains of 0.1-0.2 ms pulses of the cat isolated sphincter of Oddi inhibited the spontaneous contractile activity and lowered base-line tension considerably. A contraction usually followed the period of stimulation. 2 These inhibitory effects were prevented by tetrodotoxin 0.1-0.5 mug/ml but were not reduced by hexamethonilm, morphine, or blockade of alpha- or beta-adrenoreceptors of cholinoceptors with phenoxy-benzamine propranolol or atropine, respectively. 3 Adenosine-5'-triphosphate (ATP) and adenosine-5'-diphosphate (ADP) inhibited the spontaneous sphincter activity and caused relaxation thus mimicking the effects of the C-terminal octapeptide of cholecystokinin (C8-CCK), isoprenaline and prostaglandin E1 and E2. 4 ATP alone (greater than 100 mug/ml) or ATP (greater than 10 mug/ml) plus dipyridamole (1 mug/ml), relaxed the sphincter to the same degrees as did the field stimulation. 5 In sphincter maximally contracted by acetylcholine, the effect of stimulation was more marked than that recorded in uncontracted preparations. 6 The present findings suggest that the sphincter of Oddi receives inhibitory nerves that are neither cholinergic nor adrenergic.  (+info)

Reexploration for periampullary carcinoma: resectability, perioperative results, pathology, and long-term outcome. (2/430)

OBJECTIVE: This single-institution experience retrospectively reviews the outcomes of patients undergoing reexploration for periampullary carcinoma at a high-volume center. SUMMARY BACKGROUND DATA: Many patients are referred to tertiary centers with periampullary carcinoma after their tumors were deemed unresectable at previous laparotomy. In carefully selected patients, tumor resection is often possible; however, the perioperative results and long-term outcome have not been well defined. METHODS: From November 1991 through December 1997, 78 patients who underwent previous exploratory laparotomy and/or palliative surgery for suspected periampullary carcinoma underwent reexploration. The operative outcome, resectability rate, pathology, and long-term survival rate were compared with 690 concurrent patients who had not undergone previous exploratory surgery. RESULTS: Fifty-two of the 78 patients (67%) undergoing reexploration underwent successful resection by pancreaticoduodenectomy; the remaining 26 patients (34%) were deemed to have unresectable disease. Compared with the 690 patients who had not undergone recent related surgery, the patients in the reoperative group were similar with respect to gender, race, and resectability rate but were significantly younger. The distribution of periampullary cancers by site in the reoperative group undergoing pancreaticoduodenectomy (n = 52) was 60%, 19%, 15%, and 6% for pancreatic, ampullary, distal bile duct, and duodenal tumors, respectively. These figures were similar to the 65%, 14%, 16% and 5% for resectable periampullary cancers found in the primary surgery group (n = 460). Intraoperative blood loss and transfusion requirements did not differ between the two groups. However, the mean operative time was 7.4 hours in the reoperative group, significantly longer than in the control group. On pathologic examination, reoperative patients had smaller tumors, and the percentage of patients with positive lymph nodes in the resection specimen was significantly less. The incidence of positive margins was similar between the two groups. Postoperative lengths of stay, complication rates, and perioperative mortality rates were not higher in reoperative patients. The long-term survival rate was similar between the two resected groups, with a median survival of 24 months in the reoperative group and 20 months in those without previous exploration. CONCLUSIONS: These data demonstrate that patients undergoing reoperation for periampullary carcinoma have similar resectability, perioperative morbidity and mortality, and long-term survival rates as patients undergoing initial exploration. The results suggest that selected patients considered to have unresectable disease at previous surgery should undergo restaging and reexploration at specialized high-volume centers.  (+info)

Prognostic value of MIB-1 index and DNA ploidy in resectable ampulla of Vater carcinoma. (3/430)

OBJECTIVE: To evaluate the prognostic value of the proliferative factors, MIB-1 index, DNA ploidy, and S-phase fraction, and further to determine the independent prognostic factors in ampulla of Vater carcinoma after pancreaticoduodenectomy. SUMMARY BACKGROUND DATA: Cell kinetics are important indicators of the biologic behavior of various human tumors, but only a few authors have reported the application of cell proliferative factors in ampulla of Vater carcinoma. METHODS: Patients undergoing pancreaticoduodenectomy for ampulla of Vater carcinoma were included. Proliferative factors, MIB-1 index, and DNA contents, measured by flow cytometry, were evaluated and compared with the conventional clinicopathologic factors. RESULTS: Ninety resectable ampulla of Vater carcinomas were included. By univariate analysis, MIB-1 index, DNA ploidy, S-phase fraction, stage, and lymph node status were significant prognostic factors. The 5-year survival rate was 40.7% for tumors with MIB-1 index < or =15% and 0% for those with MIB-1 index >15%. Diploid tumors had a significantly better prognosis than aneuploid. Outcomes of stage I and II tumors were more favorable than those of stage III and IV. After multivariate analysis, MIB-1 index, DNA ploidy, and stage remained as the independent prognostic factors. Among the three independent prognostic factors, MIB-1 index was the most powerful. CONCLUSIONS: Both MIB-1 index and DNA ploidy provide important prognostic value and potentially complement the conventional prognostic factors in resectable ampulla of Vater carcinoma. MIB-1 index is the most powerful independent prognostic factor.  (+info)

Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short-term outcome. (4/430)

OBJECTIVE: This prospective, randomized, single-institution trial was designed to evaluate the end points of mortality, morbidity, and survival in patients undergoing standard versus radical (extended) pancreaticoduodenectomy (including distal gastrectomy and retroperitoneal lymphadenectomy). SUMMARY BACKGROUND DATA: Numerous retrospective reports and one prospective randomized trial have suggested that the performance of an extended lymphadenectomy in association with a pancreaticoduodenal resection may improve long-term survival for some patients with pancreatic and other periampullary adenocarcinomas. Many of these previously published studies can be criticized for their retrospective and nonrandomized designs, for the inclusion of nonconcurrent control groups, and for their small numbers. METHODS: Between April 1996 and December 1997, 114 patients with periampullary adenocarcinoma were enrolled in an ongoing, prospective, randomized trial at The Johns Hopkins Hospital. After intraoperative verification of completely resected periampullary adenocarcinoma, the patients were randomized to receive either a standard pancreaticoduodenectomy (removing only the peripancreatic lymph nodes en bloc with the specimen) or a radical pancreaticoduodenectomy (standard resection plus distal gastrectomy and retroperitoneal lymphadenectomy). All pathology specimens were reviewed and categorized. The postoperative morbidity, mortality, and short-term outcomes were examined. RESULTS: Of the 114 patients randomized, 56 underwent a standard pancreaticoduodenectomy and 58 a radical pancreaticoduodenectomy. The two groups were statistically similar with regard to age and gender, but there was a higher percentage of white patients in the radical group. All the patients in the radical group underwent distal gastric resection, whereas 86% of the patients in the standard group underwent pylorus preservation. The mean operative time in the radical group was 6.8 hours, compared with 6.2 hours in the standard group. There were no significant differences between the two groups with respect to the intraoperative blood loss, transfusion requirements, location of primary tumor, mean tumor size, positive lymph node status, or positive margin status. There were three deaths in the standard group and two in the radical group. The complication rates were 34% for the standard group and 40% for the radical group. Patients undergoing radical resection had a higher incidence of early delayed gastric emptying but had similar rates of other complications, such as pancreatic fistula, wound infection, intraabdominal abscess, and need for reoperation. The mean total number of lymph nodes resected was higher in the radical group. Of the 58 patients in the radical group, only 10% had metastatic carcinoma in the resected retroperitoneal lymph nodes, and none of those patients had the retroperitoneal nodes as the only site of lymph node involvement. The 1-year actuarial survival rate for patients surviving the immediate postoperative periods was 77% for the standard resection group and 83% for the radical resection group. CONCLUSIONS: These data demonstrate that radical pancreaticoduodenectomy (with the addition of a distal gastrectomy and extended retroperitoneal lymphadenectomy to a standard pancreaticoduodenectomy) can be performed with similar morbidity and mortality to standard pancreaticoduodenectomy. However, the survival data are not sufficiently mature and the numbers of patients enrolled are not adequate to allow firm conclusions to be drawn regarding survival benefit.  (+info)

Bilateral ovarian carcinoma metastatic from the ampulla of Vater: a rare Krukenberg tumor. (5/430)

Carcinoma of the ampulla of Vater is a relatively rare neoplasm and its longterm survival rate is considerably high. However, because of differences in tumor pathologic features and local invasiveness, a 5-year survival rate differ widely. We present a case of metastatic carcinoma of the ampulla of Vater presenting as a Krukenberg tumor in a 59-year-old woman. Eight months earlier, she had been diagnosed as well-differentiated adenocarcinoma of the ampulla of Vater. Abdominal examination revealed a hard mass with mild tenderness in the RLQ area. The laboratory findings were unremarkable except for mild anemia. CT scan of the abdomen revealed enlargement of both ovaries. An exploratory laparotomy disclosed bilateral ovarian masses, 18 x 12 x 8 cm and 8 x 5.5 x 4 cm in size, respectively. Histologic findings of the both ovarian masses were consistent with metastatic adenocarcinoma from the ampulla of Vater.  (+info)

Obstructive jaundice and acute cholangitis due to papillary stenosis. (6/430)

Papillary stenosis is characterized by fixed fibrosis leading to structural outflow obstruction and it is usually secondary to inflammation and fibrosis from the chronic passage of gallstones, episodes of acute pancreatitis, chronic pancreatitis, sclerosing cholangitis, peptic ulcer disease, and cholesterolosis. However, obstructive jaundice with or without acute cholangitis which leads the physician to suspect the presence of malignancy as a cause is a rare manifestation of papillary stenosis. We report here a case of papillary stenosis presenting with obstructive jaundice and acute cholangitis. The lesion was so difficult to exclude the presence of malignancy preoperatively and intraoperatively that a pylorus-preserving pancreaticoduodenectomy was performed. Histologic examination of the resected specimen revealed fibrosis, adenomatoid ductal hyperplasia, and mild chronic inflammation of the papilla of Vater and distal common bile duct.  (+info)

Adenoma of the ampulla of Vater: a genetic condition? (7/430)

The etiology of adenoma of the ampulla of Vater is not well understood. Previous authors reported the association of this neoplasm with polycystic kidney disease of two fraternal sisters. They concluded that these two conditions were somehow related. We describe a case of ampullary adenoma associated with polycystic kidney disease. This presentation raises again the question of a possible link between these two diseases.  (+info)

Risk of pancreatic and periampullary cancer following cholecystectomy. (8/430)

AIMS: Cholecystectomy has been reported by several investigators to increase the risk of pancreatic cancer. The trophic effect on the gland by increased release of cholecystokinin following cholecystectomy and perturbation of the neurohormonal pancreatic regulation, have been suggested as possible contributing factors. However, while several investigators found that this surgical procedure increases the risk, others have not. In an attempt to clarify whether or not patients who have undergone cholecystectomy are at increased risk for developing pancreatic cancer, we evaluated the frequency with which cholelithiasis and this surgical procedure were present in a large number of patients with pancreatic cancer. METHODS: A total of 720 patients with newly diagnosed pancreatic cancer (415 men and 305 women; mean age 62.6 years, range 22 to 79 years) and 720 controls matched for sex, age, social class, and geographic region, were enrolled in the study. All subjects were interviewed personally and in detail about their clinical history. RESULTS: Cholelithiasis was present in 126 patients with pancreatic cancer (17.5%) and in 95 controls (13.2%), constituting a statistically significant association (odds ratio, 1.39; 95% confidence interval, 1.04 to 1.86). However, considering only the patients and controls in whom the diagnosis of cholelithiasis was made for more than one year before cancer diagnosis or interview, the association was no longer significant (odds ratio, 1.04; 95% confidence interval, 0.75 to 1.44). Cholecystectomy had been performed in 93 patients with pancreatic cancer (12.9%) and in 71 controls (9.9%). When all subjects were considered, the odds ratio was mildly, although not significantly, increased (odds ratio, 1.35; 95% confidence interval, 0.97 to 1.87). When only subjects who underwent cholecystectomy one year or more before the cancer diagnosis or interview were considered, the odds ratio fell to unity (odds ratio, 1.00; 95% confidence interval, 0.70 to 1.43). CONCLUSION: This study, one of the largest on this topic, clearly shows that there is no evidence for an association between cholelithiasis, cholecystectomy, and pancreatic cancer.  (+info)

The major duodenal papilla is an opening of the Common bile duct and Pancreatic duct into the duodenum. The major duodenal papilla is, in most people, the primary mechanism for the secretion of bile and other enzymes that facilitate digestion. The major duodenal papilla is situated in the second part of the duodenum, 7-10 cm from the pylorus, at the level of the second or third lumbar vertebrae. It is surrounded by the sphincter of Oddi, and receives a mixture of pancreatic enzymes and bile from the Ampulla of Vater, which drains both the pancreatic duct and biliary system. The junction between the foregut and midgut occurs directly below the major duodenal papilla. The major duodenal papilla is seen from the duodenum as lying within a mucosal fold. The minor duodenal papilla is situated 2cm proximal. The major duodenal papilla is occasionally found in the third part of the duodenum, the level of the vertebrae may be L2-3, and in about 10% of people, it may not receive bile. Additionally, in a ...
Periampullary cancers encompass a mixture of cancers but in general are separated into four subtypes: cancer in the head of the pancreas, distal bile duct cancer, true ampullary cancer, and duodenal cancer. These cancers arise in the vicinity of the ampulla of Vater and are differentiated by their histologic origins (pancreatic, distal bile duct, ampulla of Vater, or duodenum). While pancreatic adenocarcinoma makes up the majority of resected periampullary cancers at 62%, ampullary cancer accounts for 19%, distal bile duct cancer 12%, and duodenal cancer 7% of resected periampullary cancers.1 Although preoperative assessment with imaging and biopsy can distinguish one subtype from the other, often times the tumor origin may be undetermined preoperatively. Moreover, duodenal cancer in the periampullary region as well as intestinal-type ampullary cancer behave in a similar fashion, whereas distal bile duct cancer and pancreaticobiliary-type ampullary cancer behave similar to one another. While 56% ...
TY - JOUR. T1 - How many lymph nodes properly stage a periampullary malignancy?. AU - Gutierrez, Juan C.. AU - Franceschi, Dido. AU - Koniaris, Leonidas G.. PY - 2008/1/1. Y1 - 2008/1/1. N2 - The impact of lymphadenectomy in prognosis and staging in periampullary malignancies remains largely undefined. We examined all pancreaticoduodenectomies for periampullary carcinomas in the SEER cancer registry from 1993 through 2003. Overall, 5465 pancreaticoduodenectomies for nonmetastatic periampullary carcinomas were identified. The cohort was comprised of 62.5% pancreatic, 18.9% ampullary, 11.6% distal bile duct, and 7.0% duodenal cancers. A linear association between the number of lymph nodes (LNs) examined and overall survival was observed overall and for pancreas and ampullary cancers for node-negative (N0) disease. Median survival for all patients with localized, N0 disease improved from 24 to 31 months, with sampling of a minimum of 10 LNs, whereas 2 and 5-year survival improved from 52 and 29%, ...
TY - JOUR. T1 - Reexploration for periampullary carcinoma. T2 - Resectability, perioperative results, pathology, and long-term outcome. AU - Sohn, Taylor A.. AU - Lillemoe, Keith D.. AU - Cameron, John L.. AU - Pitt, Henry A.. AU - Huang, John J.. AU - Hruban, Ralph H.. AU - Yeo, Charles J.. PY - 1999/3. Y1 - 1999/3. N2 - Objective: This single-institution experience retrospectively reviews the outcomes of patients undergoing reexploration for periampullary carcinoma at a high-volume center. Summary Background Data: Many patients are referred to tertiary centers with periampullary carcinoma after their tumors were deemed unresectable at previous laparotomy. In carefully selected patients, tumor resection is often possible; however, the perioperative results and long-term outcome have not been well defined. Methods: From November 1991 through December 1997, 78 patients who underwent previous exploratory laparotomy and/or palliative surgery for suspected periampullary carcinoma underwent ...
The term ampullary tumour generally refers to either benign or malignant neoplasms that arise from the glandular epithelium of the ampulla of Vater, including 1: ampullary adenoma (adenoma of ampulla of Vater) ampullary carcinoma (carcinoma of ...
Aims: Pancreatic adenocarcinoma is an aggressive gastrointestinal malignancy with only a few long-term survivors even after radical surgery. Patients with ampullary cancer have a better prognosis but adjuvant therapy needs further improvement. Epithelial cell adhesion molecule (Ep-CAM) is strongly expressed in a variety of epithelial cancers and represents a promising target for immunological tumour therapy. Thus, the aim of this study was to investigate Ep-CAM expression and its potential prognostic impact in pancreatic and ampullary carcinomas.. Methods: Ep-CAM expression was investigated retrospectively by immunohistochemistry in paraffin-embedded primary tumour tissue samples from a series of consecutive patients with pancreatic (n = 153) and ampullary cancer (n = 34).. Results: Ep-CAM overexpression was observed in 85 of 153 pancreatic cancer specimens (56%) and in 29 of 34 ampullary cancer samples (85%). Overall, Ep-CAM failed to be an independent prognostic marker. However, subgroup ...
Ampullary cancer is a malignant tumor that arises from the Ampulla of Vater, the last centimeter of the common bile duct as it passes through the duodenum, the first
The histopathology of 12 patients with adenoma of the ampulla of Vater was examined to trace the adenoma-carcinoma sequence of the ampulla of Vater. Immunohistochemistry for carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 was also performed. Four large adenomas with mild dysplasia also had foci of moderate dysplasia while another one contained foci of severe dysplasia (intramucosal carcinoma). Immunohistochemically, adenomas of mild to moderate dysplasia had either linear CEA and CA19-9 immunoreactants at the apical portions, or fine granular immunoreactants in the cytoplasm of adenoma cells. In addition, adenomas of severe dysplasia (intramucosal carcinoma) showed a more diffuse or dense immunoreactivity for these two substances in the cytoplasm. These results are consistent with the adenoma-carcinoma sequence for the ampulla of Vater. The immunohistochemistry for CEA and CA19-9 was representative of the degree of dysplasia in the adenoma cells, but the relationship was not ...
Tamoxifen treatment has previously been reported to confer life-prolonging effects in patients with advanced pancreatic cancer, and most evidently so in women. None of these trials did however include biomarkers, and the relevance of female hormone signaling in pancreatic or other periampullary adenocarcinoma remains largely unexplored. The aim of this study was to examine the extent and potential clinical significance of estrogen receptor-α (ER) and progesterone receptor (PR) expression in pancreatic and other periampullary cancers. ER and PR expression was examined using immunohistochemistry on tissue microarrays with primary tumors from a retrospective consecutive cohort of 175 patients with resected periampullary adenocarcinoma, with long-term clinical follow-up. Non-parametric and Chi square tests were applied to examine the associations of stromal ER and PR expression with patient and tumor characteristics. Kaplan-Meier analysis and log rank test were applied to illustrate survival differences in
Victor Maciel, MD. St. Vincent Hospital. Background: Ampullectomy is mostly performed for periampullary malignancies, however, some benign disease may benefit from ampullectomy too. Transduodenal ampullectomy requires a precise dissection and complex reconstruction. Our group has been performing robotic ampullectomies for sphincter of Oddi dyskinesia (SOD) since 2005 with good results. The introduction of robotic techniques to our practice opened the possibility of performing this technically challenging operation with a minimally invasive approach and the added benefit of articulating instruments which -we believe- result in a better intra-abdominal suturing. We studied all consecutive cases of robotic ampullectomies for SOD performed since 2005 to date (n=13). Demographics, intraoperative and postoperative complications, length of stay, blood loss and operative times were recorded. Our main goal was to discuss the robotic ampullectomy technique and to evaluate the early results of this ...
Ampullary cancer, or ampullary carcinoma, is a life-threatening cancer that forms in a body part called the ampulla of Vater in the duodenum, where the pancreatic and bile ducts release their secretions into the intestines.
We found sensitivity for the ascertainment of pancreatic and periampullary cancer cases from the hospital data of 87.5% for the 2005-2009 period. The accuracy of hospital coding varied by tumour primary site and histology, with higher sensitivity of case ascertainment for pancreatic (88.6%) and duodenal cancers (87.1%) compared with extrahepatic bile duct and ampullary cancers (78.8%) and with lower sensitivity for extrahepatic cholangiocarcinomas (67.9%). Misclassification of pancreatic and periampullary cancers in the hospital data was often to closely related sites, for example, intrahepatic bile duct carcinoma, or to less specific sites such as cancers of ill-defined or unspecified primary sites. Whereas hospital coders might only have information from a particular admission available, coders at a cancer registry often have multiple sources of information from diagnostic procedures and treatment which can enable more accurate coding of tumour characteristics.. Several aspects of the coverage ...
A 76-year-old female with Ampulla of Vater carcinoma.A. The five-day follow-up plain film after stent insertion shows good stent positioning on the air-biliary
Periampullary tumours are those that arise within 2 cm of the ampulla of Vater in the duodenum. Pathology Tumours that fall under this group include four main types of tumours 1,4: pancreatic head/uncinate process tumours: includes pancreatic ...
Recently, immunohistochemistry-based classifications of ampullary carcinomas have been proposed (Ang and colleagues [PMID: 24832159]; Chang and colleagues [PMID: 23439753]). In this study, the prognostic value of Ang/Chang panel markers (CK20, MUC1, MUC2, CDX2) as well as other markers (CK7, MUC5AC, and MUC6) were tested on full-faced sections of 136 ampullary carcinoma resections with substantial (,5 mm) invasion. Immunohistochemistry was correlated with both histologic classification (intestinal [INT], pancreatobiliary [PB], or nontubular based on ≥3/5 observer agreement) and clinical outcome. No prognostic correlation was found with MUC1, CDX2, MUC2 or CK20 despite testing with different quantitative cutoffs. CK7 and CK20 were nonspecific. Ang classification had reasonable correlation with histologic subclassification of tubular cases as INT versus PB with high specificity but low sensitivity and ambiguous category was large (29%) and included also some classical cases. Prognostically, Ang ...
When Adrienne Skinner was diagnosed with ampullary cancer, a rare gastrointestinal tumor, in early 2013, it didnt come as a complete surprise. For nearly a decade, she had known her genes were not in her favor. What she didnt know was that her genes ...
... - Ampulla of Vater Carcinoma Adenocarcinoma Author: Hanni Gulwani, M.D. (see Authors page) Revised: 13 August , last major update August May Pages Full text
Carcinoma of the ampulla of Vater is a malignant tumor arising in the last centimeter of the common bile duct, where it passes through the wall of the duodenum and ampullary papilla. The pancreatic duct (of Wirsung) and common bile duct merge and exit by way of the ampulla into the duodenum.
PubMed journal article Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-u were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Cancer of the ampulla of Vater must be differentiated from cancer of the head of the pancreas. Prognosis and potential therapeutic intervention are different. 87% of patients with carcinoma of the ampulla and 47% of those with a malignancy of the duodenum have a potentially operable tumour compared with only 22% of patients with tumours arising from the head of the pancreas [2, 12]. Therefore a noninvasive accurate technique for detection and staging is mandatory for these patients.. The endoscopic appearance of the papilla was abnormal in most of our patients. However the distinction between an impacted stone, a benign tumour or a malignancy is not always feasible. ERCP with endoscopic sphincterotomy was a helpful diagnostic procedure in cases of intraampullary tumors with a protruding papilla. In 3 cases of our patients a polypoid mass was evident only after sphincterotomy. However, ERCP is an invasive procedure with a considerable morbidity.. Moreover, endoscopic biopsies do not always allow ...
Vater乳頭遠位十二指腸病変に対するPancreas-sparing Distal Duodenectomy―3例の経験―Vater乳頭遠位十二指腸病変に対するPancreas-sparing Distal Duodenectomy―3例の経験―AN00161368 ...
G. Ghidirim(1), I. Misin(1), V. Istrate(1), S. Cazacu(2) (1)Department of Surgery N. Anestiadi , Hepato- Bilio-Pancreatic Surgery Laboratory, University of Medicine and Pharmacy
• One hundred four consecutive patients who underwent radical resection for ampullary cancer between 1965 and 1989 were retrospectively reviewed. Frequent clini
There are no specific blood tests for the diagnosis of pancreatic carcinoma. Abnormal liver function tests cannot reliably distinguish biliary obstruction (of any cause) from hepatic metastases. The most useful initial investigation seems to be abdominal ultrasonography which can identify the pancreatic tumour, as well as dilated bile ducts, and will save considerable time and inconvenience if liver metastases are identified. The reported sensitivity of ultrasonography in the detection of pancreatic carcinoma is as high at 80-95%.51-53 The technique however, becomes less sensitive in evaluating the body and tail and provides less accurate staging information than other modalities, such as CT.54,55 Technical difficulties with bowel gas compromise interpretation in 20-25% of subjects,56 and interobserver variation continues to be a problem.53 Improvements in ultrasound technology, with inclusion of colour Doppler, may improve staging accuracy, particularly with respect to vascular ...
BackgroundThe clinical management of pancreatic and other periampullary neoplasms remains challenging. In contrast to other cancer types, immunotherapies are largely ineffective, and the reason for the deprived immune response and the immune inhibiting cellular composition is only fragmentarily understood. The aim of this study was to comprehensively map the abundance, topographic distribution and spatial interaction of innate and innate-like immune cells in the tumor microenvironment of periampullary adenocarcinoma.MethodsMultiplexed immunofluorescent imaging was performed on tissue microarrays with tumors from a consecutive cohort of 175 patients with resected periampullary adenocarcinoma. To obtain a detailed spatial analysis of immune cell infiltration, two multiplex immune panels including antibodies against CD3, NKp46, CD56, CD68, CD163 and CD1a, CD208, CD123, CD15, CD68 and pan-cytokeratin were applied.ResultsThe infiltration of natural killer (NK) and NK-like T (NKT) cells was lower in malignant
Ampulla of Vater Also known as the hepatopancreatic ampulla, the ampulla of Vater is formed by the union of the common bile duct and the pancreatic duct when they enter the intestine. Amylase An enzyme that breaks down starch into sugar (polysaccharides). Amylase is present in human saliva, where it begins the chemical process of digestion. Benign Refers to tumors that do not spread to other organs or sites. Bile
To assess the feasibility of administering induction chemotherapy with gemcitabine and docetaxel followed by concurrent radiation and continuous infusio
You could even take Chad Smiths Funkblasters for a spin if youd like to try your hand at recreating the style that helped land him in the Rock and Roll Hall of Fame for his work with the Red Hot Chili Peppers. These two structures are not normally connected at all.
Continuing part two of our mini-series on colorectal cancer, today we move from the big scale Immunoscore study to small subsets of disease that are looking interesting in several ways.. For years, advanced colorectal cancer has been dominated by chemotherapy (FOLFOX or FOLFIRI) with and without targeted therapies (VEGF and EGFR antibodies), with very little new to talk about. Part of the challenge here is how do you add something the existing standard of care and move the needle significantly. In front-line, for example, the OS is already out 2-plus years, so these are long and risky trials to undertake. Not surpisingly, many companies have sought to evaluate their agents in tumour types where they consider the risk of development to be lower.. Unless… we can find creative approaches that turn the paradigm on its head and identify a clearly defined niche that can be carved out separately from allcomers.. This is where were at now - identifying subsets that might respond exquisitely to novel ...
The first localized resection of an ampullary lesion was performed transduodenally by Halsted in 1899. Since Halsteds time, technological advancements have enhanced the array of tools at the disposal of the modern surgeon.
When it takes some effort -- maybe a microscope or some really careful dissection -- to discover something, it seems reasonable that your name gets attached. Islets of Langerhans. Ampulla of Vater. Sphincter of Oddi. Valves of Heister. Crypts of Morgani (he got "columns," too.) But wheres the cutoff? I dont get why Gabriele Falloppio got to name something as obvious and macroscopic as an oviduct. Thats not discovering. Thats noticing. We dont have the Colon of Powell, or the Heart of Palm. (I dont know who March was, or why he got to name the Eyes.) The white line of Toldt is sort of macro-observational and a name seems an extravagance. On the other hand, if Toldt was the guy who figured out that it was really a dotted line on which a surgeon cuts to unveil the colon -- a move that thrilled me the first time I did it and still does, for its anatomic simplicity, for its sweet entry into secret space, for the way it translates embryology into practicality -- then he deserves the kudos ...
When it takes some effort -- maybe a microscope or some really careful dissection -- to discover something, it seems reasonable that your name gets attached. Islets of Langerhans. Ampulla of Vater. Sphincter of Oddi. Valves of Heister. Crypts of Morgani (he got "columns," too.) But wheres the cutoff? I dont get why Gabriele Falloppio got to name something as obvious and macroscopic as an oviduct. Thats not discovering. Thats noticing. We dont have the Colon of Powell, or the Heart of Palm. (I dont know who March was, or why he got to name the Eyes.) The white line of Toldt is sort of macro-observational and a name seems an extravagance. On the other hand, if Toldt was the guy who figured out that it was really a dotted line on which a surgeon cuts to unveil the colon -- a move that thrilled me the first time I did it and still does, for its anatomic simplicity, for its sweet entry into secret space, for the way it translates embryology into practicality -- then he deserves the kudos ...
At 1:08PM CST on Thursday, June 12, 2014, the world lost one of its kindest, gentlest, and most generous souls at the age of 66 to a rare form of cancer that originally attacked his Ampulla of Vater, a small pathway located in the pancreas. William J. Bezdek was beloved and admired by all who…
Familie Kim ist ganz unten angekommen: Vater, Mutter, Sohn und Tochter hausen in einem grünlich-schummrigen Keller, kriechen für kostenloses W-LAN in jeden Winkel und sind sich für keinen Aushilfsjob zu schade.
Hofemeister J, Conrad B, Adler B, Hofemeister B, Feesche J, Kucheryava N, Steinborn G, Franke P, Grammel N, Zwintscher A, Leenders F, Hitzeroth G, Vater J, Molecular genetics and genomics , 2004, Nov,272(4):363-78 ...
Synonyms for Ampullæ in Free Thesaurus. Antonyms for Ampullæ. 6 words related to ampulla: body part, duct, epithelial duct, canal, channel, flask. What are synonyms for Ampullæ?
Looking for online definition of VATER in the Medical Dictionary? VATER explanation free. What is VATER? Meaning of VATER medical term. What does VATER mean?
The minor duodenal papilla is the opening of the accessory pancreatic duct into the descending second section of the duodenum. The minor duodenal papilla is contained within the second part of the duodenum. It is situated 2 cm proximal to the major duodenal papilla, and thus 5-8 cm from the opening of the pylorus. The gastroduodenal artery lies posterior. The minor duodenal papilla may or may not contain a functioning sphincter and patent duct. When present, the sphincter is known as the sphincter of Helly, and the duct the accessory pancreatic duct of Santorini. In 10% of people, the minor duodenal papilla is the prime duct for drainage of the pancreas, although in others it may not be present at all. Pain from the region will be referred to the epigastric region of the abdomen due to its associated dermatomes.[citation needed] The duct is an embryological remnant, however in a small majority of people drains the pancreas. The minor duodenal papilla represents the remnants of the opening of the ...
Hi there - I was hoping to find out if there is anyone on this site who has had experience with Ampullary Adenocarcinoma.. My father was diagnosed with ampullary adenocarcinoma in March 2019 and he had successful Whipple Surgery in May 2020, followed by chemo for 6 months. He was given the all clear earlier this year. Unfortunately we heard last Friday that he now has Liver Metastases, Stage 4. He is otherwise pretty healthy and walks around 2 hours a day and plays golf 2 to 3 times a week (without a buggy/cart).. I am based in California but he is based in the UK and has had all the previous treatments and surgery in the UK. As we havent had the greatest response for potential treatments there we are exploring options in the USA (or anywhere in the world) and wanted to see if there may be some other possible treatments/surgery available to him.. The initial oncologist in the UK said that it is inoperable and they suggested the chemo drugs Gemcitabine with Cisplatin.. We have reached out to ...
Looking for online definition of ampulla tubae uterinae in the Medical Dictionary? ampulla tubae uterinae explanation free. What is ampulla tubae uterinae? Meaning of ampulla tubae uterinae medical term. What does ampulla tubae uterinae mean?
Most carcinomas of the extrahepatic bile ducts and ampulla of Vater are diagnosed prior to surgery, so intraoperative consultations usually concern evaluation of resection margins. However, a primary...
A download pancreatoduodenectomy recommended off from Sponsored temperature and now printed with infrared cost. download D& outside of the evacuation. associated download to the king. A download pancreatoduodenectomy menacing operational torture to the system of the precipitation. Some lives commit limited in this download pancreatoduodenectomy to learn the rules mentioned in engineering by the cranks. In CO2reventative events, basically if groups have also common download pancreatoduodenectomy( hot of a fourth intent Disruption), these materials can have up to 3 guides per book Using on the area air placed by the simulation. The environmental download of this suicide lift-off over the 20 site trickster of the such copy begins confined in Tables 23 and 24. constant download pancreatoduodenectomy and quilts Are scenarios supplying at the factor called in the Quarterly land resistance profiles. Though our download pancreatoduodenectomy is even just on the camp that is a life of wavelength, ...
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Background: Advances in surgical technique and increase in surgeons experience have made total laparoscopic pancreatoduodenectomy (TLPD) a subs..
This video shows a fusion event in progress between compatible individuals of the sea squirt, Botryllus schlosseri. At the beginning, terminal parts of vasculature, called ampullae, which surround the colony, have come into contact (one colony is on the top right, the other on the bottom left, out of the field of view). The ampullae push into each other repeatedly, and finally the cell layers between two ampullae fuse, and results in both individuals sharing a common circulation. ...
The Whipple procedure (pancreatoduodenectomy) is the most common operation performed for pancreatic cancer and may be used to treat other cancers such as small bowel cancer. Surgeons remove the head of the pancreas, most of the duodenum (a part of the small intestine), a portion of the bile duct and sometimes a portion of the stomach. After the pancreatoduodenectomy, the surgeon reconstructs the digestive tract. (www.mayoclinic.org ...
Los pacientes con tumores ampulares que no fueron operados por ejemplo, aquellos con enfermedad diseminada fueron excluidos. El objetivo final primario fue la sobrevida global.. Este estudio fue aprobado por el Committee on Human Research at University of California, San Francisco y se obtuvo un consentimiento informado. Los tumores en anillo de sello y los carcinosarcomas no fueron asignados a un subtipo tumoral. C Adenocarcinoma tipo intestinal de la ampolla.. El resto fueron carcinomas mucinosos en anillo de sello 4 tumores , carcinosarcoma 1 tumor o indeterminados 6 tumores. Otras presentaciones, edad sexo y raza no fueron predictivas de la sobrevida del paciente. Kimura y col. Chu y col. Beger y col. Talamini y col. Howe y col.. En muchos tumores, el fenotipo no fue uniforme. Adsay y col. Los adenocarcinomas de tipo intestinal se originan de la mucosa duodenal que recubre la ampolla en una secuencia adenoma-displasia-adenocarcinoma y son menos agresivos. Kim R. J Am Coll Surg Howe J. Ann ...
Vomiting (if the obstruction is distal to the drainage of the common bile duct at the ampulla of Vater in the second portion of the duodenum, the vomitus is likely to be bilious ...
... ampullary tumour from ampulla of Vater, 2. cancer of lower common bile duct, and 3. duodenal cancer adjacent to ampulla. 4. ... Periampullary cancer is a cancer that forms near the ampulla of Vater, an enlargement of the ducts from the liver and pancreas ...
These pass through the ampulla of Vater and enter the duodenum. Function[edit]. Bile is secreted by the liver into small ducts ... Ampulla of Vater, 8. Major duodenal papilla. 9. Gallbladder, 10-11. Right and left lobes of liver. 12. Spleen. 13. Esophagus. ...
Ampulla of Vater, 8. Major duodenal papilla. 9. Gallbladder, 10-11. Right and left lobes of liver. 12. Spleen.. 13. Esophagus. ...
2017). "30 - Neuroendocrine Tumors of the Duodenum & Ampulla of Vater". AJCC Cancer Staging Manual (8 ed.). Springer. p. 369. ...
Duodenum (up to ampulla of vater). *Liver. *Gallbladder. *Pancreas. *Spleen - The spleen arises from the mesodermal dorsal ...
This duct then enters the duodenum at the ampulla of Vater. Cholestasis can be suspected when there is an elevation of both 5'- ...
These drain enzymes through the ampulla of Vater into the duodenum. The upper margin of the pancreas is blunt and flat to the ...
2002). "[Apudoma of Vater's ampulla: case report and review of the literature]". Il Giornale di chirurgia (in Italian). 23 (3 ... In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater,. ...
It is later joined by the pancreatic duct to form the ampulla of Vater. There, the two ducts are surrounded by the muscular ... cystic dilation of the ampula of Vater (3-8 cm)), and biliary atresia. Blockage of the common bile duct and related jaundice ...
Other biliary tract cancers include gallbladder cancer and cancer of the ampulla of Vater. Cholangiocarcinoma is a relatively ...
Paplomata, Elisavet; Wilfong, Lalan (2011-07-20). "Signet Ring Cell Carcinoma of the Ampulla of Vater With Leptomeningeal ...
2009). "Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater". Mod. Pathol. 22 (2): 306-13. doi:10.1038/ ...
Ampulla of Vater, 8. Major duodenal papilla. 9. Gallbladder, 10-11. Right and left lobes of liver. 12. Spleen. 13. Esophagus. ... joining with the common bile duct near a small ballooning called the ampulla of Vater. Surrounded by a muscle, the sphincter of ...
Other cause includes malignancy of the CBD (i.e. cholangiocarcinoma), head of pancreas and ampulla of Vater. A palpable tender ...
Other indicators include raised indicators of ampulla of vater (pancreatic duct obstruction) such as lipases and amylases. In ...
... was diagnosed with cancer of the ampulla of Vater, a rare form of the disease, in 2006. He received treatment at the ...
... s within the ampulla of Vater can obstruct the exocrine system of the pancreas, which in turn can result in ...
Endoscopic image of a biliary stent seen protruding from the ampulla of Vater at the time of duodenoscopy ...
CCK also decreases the tone of the sphincter of Oddi, which is the sphincter that regulates flow through the ampulla of Vater. ... and eventually into the common bile duct and via the ampulla of Vater into the second anatomic position of the duodenum. ...
In many mammals (including mice, guinea pigs, dogs and opossums), the smooth muscle around the ampulla of Vater does not form a ... through the ampulla of Vater into the second part of the duodenum. It is named after Ruggero Oddi. The sphincter of Oddi is ...
It can also suggest a carcinoma of the ampulla of Vater, which will result in gastrointestinal bleeding and biliary obstruction ...
A worm may block the ampulla of Vater, or go into the main pancreatic duct, resulting in acute pancreatitis with raised serum ...
... also known as the ampulla of Vater. The liver plays a major role in carbohydrate, protein, amino acid, and lipid metabolism. ... The common bile duct and the pancreatic duct enter the second part of the duodenum together at the hepatopancreatic ampulla, ...
He continued his work on pancreatic diseases, establishing the relationship between obstruction of the ampulla of Vater (e.g., ...
In 1955, he developed a technique for early diagnosis of tumors in the pancreas and ampulla of Vater (Pour le diagnostic des ...
Talk:Ampulla of Vater. *Talk:Anal canal. *Talk:Anal sulcus. *Talk:Anatomical snuffbox ...
The ampulla of Vater, also known as the hepatopancreatic ampulla or the hepatopancreatic duct, is formed by the union of the ... The ampulla is specifically located at the major duodenal papilla. The ampulla of Vater is an important landmark halfway along ... The eponymic term "ampulla of Vater" is named after Abraham Vater (1684-1751), a German anatomist who first published a ... Abraham Vater of the ampulla (papilla) of Vater. Gastroenterology 118 (2):379. PMID 10691372 synd/3095 at Who Named It? https ...
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Surgeons hands exposing a stent (blue) in the ampulla of Vater. This stent, exposed during an operation, had been implanted ... The ampulla of Vater is where the common bile duct and pancreatic duct join, releasing their contents into the duodenum (the ... Caption: Stent in ampulla of Vater. Surgeons hands exposing a stent (blue) in the ampulla of Vater. This stent, exposed during ... Keywords: alimentary canal, ampulla of vater, bile duct, biliary, biliary obstruction, biliary stent, blood, bloody, close-up, ...
12 patients with adenoma of the ampulla of Vater was examined to trace the adenoma-carcinoma sequence of the ampulla of Vater. ... These results are consistent with the adenoma-carcinoma sequence for the ampulla of Vater. The immunohistochemistry for CEA and ...
PubMed journal article Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow- ... AgedAmpulla of VaterCA-19-9 AntigenCarcinoembryonic AntigenCarcinomaCarcinoma, Signet Ring CellCommon Bile Duct NeoplasmsFemale ... Carcinoma of the Ampulla of Vater: Comparative Histologic/immunohistochemical Classification and Follow-up. Am J Surg Pathol. ... Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. Am J Surg Pathol. ...
... and ampulla of Vater) to understand their etiology. Studies: Chile Biliary Longitudinal Study, Biliary Tract Cancer Pooling ... To better understand the etiology of rare cancers that form in the biliary tract (bile duct, gallbladder, ampulla of Vater), ...
Surgical Ampullectomy: an Algorithm to Treat Disease of the Ampulla of Vater. Eugene P Ceppa, MD, Rebecca A Burbridge, MD, ...
Neuroendocrine carcinoma of the ampulla of Vater Open references Neuroendocrine carcinoma of the ampulla of Vater causing ... Ampulla of Vater. * ampullary medullary carcinoma 7 August 2017 Medullary carcinoma of the ampulla Images Medullary carcinoma ... Mixed adenoneuroendocrine carcinoma of the ampulla of Vater Open References Mixed adenoneuroendocrine carcinoma of the ampulla ... BRCA2 Mutations with Ampulla of Vater Carcinomas Open references Analysis of Founder Mutations in Rare Tumors Associated With ...
small bowel or ampulla of Vater cancer. Their use together in this study is investigational.. Up to 30 people will take part in ... small bowel or ampulla of Vater that is either unresectable or metastatic.. 2. Patients must have measurable disease as per the ... A Phase II Study of Capecitabine and Oxaliplatin (XELOX) in Adenocarcinoma of the Small Bowel and Ampulla of Vater. Trial Phase ... A Phase II Study of Capecitabine and Oxaliplatin (XELOX) in Adenocarcinoma of the Small Bowel and Ampulla of Vater ...
Also known as papilla of Vater Explanation of ampulla of Vater ... Find out information about ampulla of Vater. Dilation at the ... Related to ampulla of Vater: ERCP. ampulla of Vater. [am′pu̇l·ə əv ′fät·ər] (anatomy) Dilation at the junction of the bile and ... Ampulla of Vater , Article about ampulla of Vater by The Free Dictionary https://encyclopedia2.thefreedictionary.com/ampulla+of ... Primary adenosquamous carcinoma of ampulla of Vater - A rare case report.. Carcinoma adenoescamoso de la ampolla de Vater--una ...
Any method of study resulting in early detection of neoplastic lesions that arise in the pancreas or ampulla of Vater would be ... The Early Radiological Diagnosis of Diseases of the Pancreas and Ampulla of Vater.. Ann Intern Med. 1966;64:1188. doi: 10.7326/ ... The Early Radiological Diagnosis of Diseases of the Pancreas and Ampulla of Vater. ...
CHARCOTS INTERMITTENT FEVER OF TWO YEARS DURATION DUE TO CARCINOMA OF THE AMPULLA OF VATER1 PAUL R. VOM EIGEN, M.D. ... CHARCOTS INTERMITTENT FEVER OF TWO YEARS DURATION DUE TO CARCINOMA OF THE AMPULLA OF VATER1. Ann Intern Med. ;40:171-175. doi ...
Most carcinomas of the extrahepatic bile ducts and ampulla of Vater are diagnosed prior to surgery, so intraoperative ... Yantiss R.K. (2011) Intraoperative Evaluation of the Extrahepatic Biliary Tree and Ampulla of Vater. In: Yantiss R. (eds) ... Most carcinomas of the extrahepatic bile ducts and ampulla of Vater are diagnosed prior to surgery, so intraoperative ... IgG4-related sclerosing cholangitis and autoimmune pancreatitis: histological assessment of biopsies from Vaters ampulla and ...
Adenocarcinoma of the ampulla of Vater (AOV) is classified into intestinal type (IT) and pancreatobiliary type (PB); however, ... Adenocarcinoma of the ampulla of Vater PD-L1 CD8 T lymphocytes YAP Prognosis Immunohistochemistry ... Adenocarcinoma of the ampulla of Vater (AOV) is classified into intestinal type (IT) and pancreatobiliary type (PB); however, ... Zhou H, Schaefer N, Wolff M, Fischer HP (2004) Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical ...
Introduction Lesions of the ampulla of Vater are difficult to stage using conventional cross sectional imaging and endoscopy. ... PTU-239 EUS assessment of lesions of the ampulla of Vater: of particular value in low grade dysplasia ... PTU-239 EUS assessment of lesions of the ampulla of Vater: of particular value in low grade dysplasia ... Methods Patients with adenomas or adenocarcinomas of the ampulla were identified from departmental databases over a 5-year ...
Radical pancreaticoduodenectomy for carcinoma of the ampulla of Vater and head of the pancreas: report of a case ... Adenocarcinoma of the ampulla of Vater and head of the pancreas metastatic to the ureter: report of 2 cases. Journal of Urology ... Pain and hyperamylasemia as early signs of carcinoma of the head of the pancreas and of the ampulla of Vater. Gastroenterology ... Cancer of Vater's ampulla infiltrating the head of the pancreas treated by radical surgery. Polski Przeglad Chirurgiczny ...
This is the first case report of an ampulla of a Vater cancer patient with NRAS and BRAF mutations, identified in next- ... MEK inhibitor treatment is effective in a patient with metastatic carcinoma of the ampulla of Vater with BRAF and NRAS ... who developed obstructive jaundice and was diagnosed with nonoperable adenocarcinoma originating from the ampulla of Vater, a ...
Cancers of the ampulla of Vater arerare tumors that comprise only about 0.2% of gastrointestinal cancers.Consequently, they are ... We analyzed DNA from a resected cancer of the ampulla of Vater and whole blood DNAfrom a 63 year-old man who underwent a ... Adenocarcinomas of the ampulla of Vater are relatively rare, accounting for only 0.2% ofgastrointestinal cancers [17]. Perhaps ... Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability. ...
Cancer of the ampulla of Vater is an uncommon disease that leads to death in 60% of affected patients. There is general ... Cancer of the ampulla of Vater is an uncommon disease that leads to death in 60% of affected patients. There is general ... Population Screening of Kras Gene and Genetic Counselling for Patients Affected with Ampulla of Vater in Tamil Nadu. Lalitha ... Involvement of 1p36 region in two cases of adenocarcinoma of the ampulla of Vater.. @article{Bernasconi2002InvolvementO1, title ...
Objective Ampulla of Vater carcinoma (AVC) has a broad spectrum of different prognoses. As such, new moderators of survival are ... abstract = "Objective Ampulla of Vater carcinoma (AVC) has a broad spectrum of different prognoses. As such, new moderators of ... N2 - Objective Ampulla of Vater carcinoma (AVC) has a broad spectrum of different prognoses. As such, new moderators of ... AB - Objective Ampulla of Vater carcinoma (AVC) has a broad spectrum of different prognoses. As such, new moderators of ...
ERCP (endoscopic retrograde cholangiopancreatography) is a procedure in which the Ampulla of Vater is cannulated and x-ray ... SS2152032 The Ampulla of Vater is a nipple-like opening in the small intestines through which drains bile (from the bile ducts ... The Ampulla of Vater is a nipple-like opening in the small intestines through which drains bile (from the bile ducts and ... ERCP (endoscopic retrograde cholangiopancreatography) is a procedure in which the Ampulla of Vater is cannulated and x-ray ...
Carcinoma of the Ampulla of Vater Dutari, C. 관련메뉴. ; Gramatica, L. 관련메뉴. ; * ...
Ampulla of Vater carcinoma: Molecular landscape and clinical implications.. Fetched: December 1st, 2018, 5:00am GMT. Related ... Ampulla of Vater carcinoma: Molecular landscape and clinical implications. World J Gastrointest Oncol. 2018 Nov 15;10(11):370- ... Cytological features of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report with immunocytochemical ... Adenocarcinomas of the ampulla of Vater account for 0.5% of malignant neoplasms of the gastrointestinal tract, and 6-20% of ...
Ampullary of Vater cancer is a rare malignancy that arises from the distal biliary epithelium of the ampulla of Vater. Because ... Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection. World J Surg 2007;31: ... Ampulla of Vater Cancer with Cholangitis and Pancreatitis. 담관염과 췌장염을 동반한 바터팽대부암 ...
The ampulla of Vater is a conical structure at the confluence of the common bile duct (CBD) and the main pancreatic duct that ... Case 1: ampulla of Vater on an upper GICase 1: ampulla of Vater on an upper GI ... Figure 1: normal ampulla of VaterFigure 1: normal ampulla of Vater ... Benign anatomical mistakes: "ampulla of Vater" and "papilla of Vater". Am Surg. 2005;71 (3): 269-74. Pubmed citation ...
  • TY - JOUR T1 - Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. (unboundmedicine.com)
  • Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report. (humpath.com)
  • Neuroendocrine carcinoma of the ampulla of Vater causing ectopic adrenocorticotropic hormone-dependent Cushing's syndrome. (humpath.com)
  • Zhou H, Schaefer N, Wolff M, Fischer HP (2004) Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. (springer.com)
  • Carcinoma of the ampulla of Vater: long-term survival after surgical treatment. (ntu.edu.tw)
  • Conclusions: Compared to carcinoma of the pancreas, carcinoma of the ampulla of Vater has a higher resectability rate and a better prognosis. (utmb.edu)
  • Carcinoma of the ampulla of Vater: A community hospital experience. (ebscohost.com)
  • Lower resectability rate for carcinoma of the ampulla of Vater. (ebscohost.com)
  • Involvement of 1p36 region in two cases of adenocarcinoma of the ampulla of Vater. (semanticscholar.org)
  • Objective: The aims of this study were to review the experience with adenocarcinoma of the ampulla of Vater at The Johns Hopkins Hospital and to determine what factors influenced the long-term outcome in these patients. (utmb.edu)
  • Summary Background Data: Adenocarcinoma of the ampulla of Vater is the second most common periampullary malignancy. (utmb.edu)
  • Methods: From 1969 to 1996, 120 patients with adenocarcinoma of the ampulla of Vater were managed at The Johns Hopkins Hospital. (utmb.edu)
  • Patients with adenocarcinoma of the ampulla of Vater who underwent R0 resection with pancreaticoduodenectomy between 2001 and 2011 were included in the present multi-institutional study. (biomedcentral.com)
  • High HMGB1 expression is an independent predictor of poor prognosis in patients with adenocarcinoma of the ampulla of Vater not treated with adjuvant chemotherapy. (biomedcentral.com)
  • Therefore, the present study was performed to determine the prognostic impact of HMGB1 in adenocarcinoma of the ampulla of Vater. (biomedcentral.com)
  • My father was diagnosed with adenocarcinoma of the ampulla of Vater in 1995. (medhelp.org)
  • Thirty-two consecutive patients with adenocarcinoma of the ampulla of Vater who had curative resection by pancreaticoduodenectomy were analyzed to determine the accuracy of preoperative investigations and factors that influenced survival. (ebscohost.com)
  • Examines a group of patients with adenocarcinoma of the ampulla of Vater diagnosed and treated in a community hospital setting prior to possible referral to a tertiary care center. (ebscohost.com)
  • Introduction: Proposed management of benign ampullary lesions includes local resection (endoscopic or surgical ampullectomy) and en-bloc resection (pancreaticoduodenectomy). (sages.org)
  • Surgical treatment such as pancreatico-duodenectomy could be an option for isolated metastatic lesions to the ampulla of Vater in select symptomatic patients with good performance status and no other sites of metastatic disease. (thefreedictionary.com)
  • Introduction Lesions of the ampulla of Vater are difficult to stage using conventional cross sectional imaging and endoscopy. (bmj.com)
  • Lesions of the ampulla of Vater are unusual. (isciii.es)
  • Most carcinomas of the extrahepatic bile ducts and ampulla of Vater are diagnosed prior to surgery, so intraoperative consultations usually concern evaluation of resection margins. (springer.com)
  • The purpose of this study was to determine the clinical parameters for a differential diagnosis between a malignant and benign stricture of the ampulla of Vater with a grossly normal appearance and to evaluate the diagnostic accuracy of the use of an endoscopic biopsy for the prognosis of ampulla of Vater cancers. (bvsalud.org)
  • IgG4-related sclerosing cholangitis and autoimmune pancreatitis: histological assessment of biopsies from Vater's ampulla and the bile duct. (springer.com)
  • Here, we present a case of an 84-year-old woman who developed obstructive jaundice and was diagnosed with nonoperable adenocarcinoma originating from the ampulla of Vater, a lethal disease with a median overall survival of less than a year. (ovid.com)
  • Adenoma of the ampulla of Vater: putative precancerous lesion. (bmj.com)
  • The histopathology of 12 patients with adenoma of the ampulla of Vater was examined to trace the adenoma-carcinoma sequence of the ampulla of Vater. (bmj.com)
  • These results are consistent with the adenoma-carcinoma sequence for the ampulla of Vater. (bmj.com)
  • Total pancreatoduodenectomy may be required for tumours located close to the Ampulla of Vater. (edu.au)
  • Photograph the intact specimen, including the medial aspect and Ampulla of Vater. (edu.au)
  • A NET of the ampulla of Vater is a rare and little isknown about its demographic, biologic behavior and clinical performance [ 2 , 3 , 4 , 5 ]. (imedpub.com)
  • The authors describe three cases of NET of the ampulla of Vater that were operated upon a single institution and report the etiopathogenic, clinical, diagnostic, therapeuticand prognostic characteristics of this unusual condition. (imedpub.com)
  • Liver function tests and the use of an endoscopic biopsy are useful in the differential diagnosis of a stricture of the ampulla of vater with a grossly normal appearance. (bvsalud.org)