Ampicillin
Ampicillin Resistance
Sulbactam
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
Microbial Sensitivity Tests
Penicillins
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Haemophilus influenzae
Drug Resistance, Microbial
beta-Lactamases
Chloramphenicol
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Gentamicins
Penicillin G
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Trimethoprim
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Sulfamethoxazole
R Factors
Drug Resistance, Bacterial
Tetracycline
Penicillanic Acid
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Enterococcus faecalis
Cephalosporins
Cephalexin
Enterococcus faecium
beta-Lactams
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Dysentery, Bacillary
DYSENTERY caused by gram-negative rod-shaped enteric bacteria (ENTEROBACTERIACEAE), most often by the genus SHIGELLA. Shigella dysentery, Shigellosis, is classified into subgroups according to syndrome severity and the infectious species. Group A: SHIGELLA DYSENTERIAE (severest); Group B: SHIGELLA FLEXNERI; Group C: SHIGELLA BOYDII; and Group D: SHIGELLA SONNEI (mildest).
Amoxicillin
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Drug Resistance, Multiple, Bacterial
Talampicillin
Carbenicillin
Probenecid
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Gram-Positive Bacterial Infections
Shigella
Klebsiella
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
Feces
Conjugation, Genetic
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
Trimethoprim-Sulfamethoxazole Combination
Nitrofurantoin
Proteus
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.
Enterococcus
Penicillin V
Cefamandole
Salmonella
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.
Ceftriaxone
Meningitis
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Streptomycin
Penicillin-Binding Proteins
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
Meningitis, Haemophilus
Chloramphenicol Resistance
Drug Therapy, Combination
Kanamycin
Nalidixic Acid
Cefuroxime
Clavulanic Acids
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Meningitis, Listeria
Inflammation of the meninges caused by LISTERIA MONOCYTOGENES infection, usually occurring in individuals under the age of 3 years or over the age of 50 years. It may occur at any age in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. Clinical manifestations include FEVER, altered mentation, HEADACHE, meningeal signs, focal neurologic signs, and SEIZURES. (From Medicine 1998 Sep;77(5):313-36)
Lactams
Plasmids
Enterobacter
Anti-Infective Agents
Urinary Tract Infections
Typhoid Fever
Bacteria
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Vancomycin
Amoxicillin-Potassium Clavulanate Combination
Mezlocillin
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Endocarditis, Bacterial
Amdinocillin Pivoxil
Shigella dysenteriae
beta-Lactam Resistance
Cefazolin
Muramoylpentapeptide Carboxypeptidase
Extrachromosomal Inheritance
Sarcina
Sulfisoxazole
Electrophoresis, Gel, Pulsed-Field
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
Aminoglycosides
Moxalactam
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Peptidyl Transferases
Citrobacter
Haemophilus
Anti-Infective Agents, Urinary
Salmonella enterica
Integrons
Cyanoacrylates
Gonorrhea
Drug Resistance, Multiple
Erythromycin
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Spectinomycin
Serum ampicillin levels in the calf: influence of dosage, route of administration and dosage form. (1/1618)
Holstein bull calves received ampicillin sodium by the intravenous, intramuscular and subcutaneous routes and ampicillin trihydrate by the intramuscular route, at a dosage of 5 mg/kg. In addition ampicillin sodium and ampicillin trihydrate were given at a 12 mg/kg dosage intramuscularly. The serum ampicillin concentrations were determined at five, 30, 60, 120, 180, 240 and 300 min after drug administration and at 360 min after ampicillin trihydrate injection. Intravenous administration gave a high initial level (16.2 mug/ml) at five min that declined to below 1 mug/ml by 120 min. Subcutaneous administration produced the lowest initial levels of drug but concentrations of drug detected did not differ significantly from the intramuscular administration at any sampling interval. The 12 mg/kg intramuscular ampicillin sodium dosage produced significantly higher levels than the 5 mg/kg dosage only at five min. Ampicillin trihydrate gave higher levels than ampicillin sodium at all times except 30 min (5 mg/kg) and five min (12 mg/kg). The serum ampicillin disappearance study (5 mg/kg intravenous) gave a two component bi-exponential curve. Kinetic analysis of the first component showed a C01 (theoretical initial conc) of 44.8 mug/ml, a ke1 (rate constant of disappearance) of 0.064 mug min and a t1/21 (calculated half-life) of 10.8 min. The Co2, ke2 and t1/22 of the second component were 6.2 mug/ml, 0.0157 mug/min and 46.2 min respectively. (+info)A case of canine salmonellosis due to Salmonella infantis. (2/1618)
A 7-year-old male dog kept outdoors manifested severe watery diarrhea with generalized weakness. Salmonella Infantis was isolated from a fecal sample and the dog recovered soon after medication with ampicillin, to which the isolate was highly sensitive. The present case was diagnosed as S. Infantis infection. Due to the importance of Salmonella in public health, soil samples were collected from the garden where the dog was kept and were examined for Salmonella, Some of them were positive for S. Infantis, however, no Salmonella was isolated from any soil samples collected after thorough disinfection of the surrounded environment. (+info)Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides. (3/1618)
The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone combinations for 10 Enterococcus faecalis strains with high-level resistance to aminoglycosides (HLRAg) and to assess the efficacy of ampicillin plus ceftriaxone, both administered with humanlike pharmacokinetics, for the treatment of experimental endocarditis due to HLRAg E. faecalis. A reduction of 1 to 4 dilutions in MICs of ampicillin was obtained when ampicillin was combined with a fixed subinhibitory ceftriaxone concentration of 4 micrograms/ml. This potentiating effect was also observed by the double disk method with all 10 strains. Time-kill studies performed with 1 and 2 micrograms of ampicillin alone per ml or in combination with 5, 10, 20, 40, and 60 micrograms of ceftriaxone per ml showed a > or = 2 log10 reduction in CFU per milliliter with respect to ampicillin alone and to the initial inoculum for all 10 E. faecalis strains studied. This effect was obtained for seven strains with the combination of 2 micrograms of ampicillin per ml plus 10 micrograms of ceftriaxone per ml and for six strains with 5 micrograms of ceftriaxone per ml. Animals with catheter-induced endocarditis were infected intravenously with 10(8) CFU of E. faecalis V48 or 10(5) CFU of E. faecalis V45 and were treated for 3 days with humanlike pharmacokinetics of 2 g of ampicillin every 4 h, alone or combined with 2 g of ceftriaxone every 12 h. The levels in serum and the pharmacokinetic parameters of the humanlike pharmacokinetics of ampicillin or ceftriaxone in rabbits were similar to those found in humans treated with 2 g of ampicillin or ceftriaxone intravenously. Results of the therapy for experimental endocarditis caused by E. faecalis V48 or V45 showed that the residual bacterial titers in aortic valve vegetations were significantly lower in the animals treated with the combinations of ampicillin plus ceftriaxone than in those treated with ampicillin alone (P < 0.001). The combination of ampicillin and ceftriaxone showed in vitro and in vivo synergism against HLRAg E. faecalis. (+info)Pharmacodynamic comparisons of levofloxacin, ciprofloxacin, and ampicillin against Streptococcus pneumoniae in an in vitro model of infection. (4/1618)
The increasing frequency of penicillin-resistant pneumococcus continues to be of concern throughout the world. Newer fluoroquinolone antibiotics, such as levofloxacin, have shown enhanced in vitro activity against Streptococcus pneumoniae. In this study, the bactericidal characteristics and pharmacodynamic profiles of levofloxacin, ciprofloxacin, and ampicillin against four isolates of S. pneumoniae were compared by using an in vitro model of infection. Standard antibiotic dosing regimens which simulated the pharmacokinetic profile observed in humans were used. Control and treatment models were sampled for bacterial CFU per milliliter over the duration of each 24- or 48-h experiment. In addition, treatment models were sampled for MIC determinations and drug concentration. Regrowth of all isolates as well as an increase in MICs throughout the study period was observed in the ciprofloxacin experiments. A limited amount of regrowth was noted during levofloxacin therapy for one isolate; however, no change in MIC was detected for any isolate. Ampicillin showed rapid and sustained bactericidal activity against all isolates. In this study, ratios of effective fluoroquinolone area under the concentration-time curve (AUC):MIC values ranged from 30 to 55. Levofloxacin, owing to its larger AUC0-24 values, has excellent and sustained activity against different pneumococcal strains superior to that of ciprofloxacin. (+info)Evaluation of bactericidal activities of LY333328, vancomycin, teicoplanin, ampicillin-sulbactam, trovafloxacin, and RP59500 alone or in combination with rifampin or gentamicin against different strains of vancomycin-intermediate Staphylococcus aureus by time-kill curve methods. (5/1618)
This in vitro study evaluated the activities of vancomycin, LY333328, and teicoplanin alone and in combination with gentamicin, rifampin, and RP59500 against Staphylococcus aureus isolates with intermediate susceptibilities to vancomycin. Ampicillin-sulbactam and trovafloxacin were also evaluated. LY333328 and ampicillin-sulbactam resulted in bactericidal activity against all isolates. The combination of gentamicin with glycopeptides showed synergistic activity, while rifampin had no added benefit. (+info)Efficacy of sulbactam alone and in combination with ampicillin in nosocomial infections caused by multiresistant Acinetobacter baumannii. (6/1618)
From March 1995 to March 1997, sulbactam was prospectively evaluated in patients with non-life-threatening multiresistant Acinetobacter baumannii infections. During this period, 47 patients were treated with sulbactam; of them, five were excluded because they had received < or =48 h of sulbactam therapy. A total of 42 patients, 27 males and 15 females with a mean age of 60+/-15 years, were finally evaluated. Infections were as follows: surgical wound, 19; tracheobronchitis, 12; urinary tract, 7; catheter-related bacteraemia, 2; and pneumonia, 2. Eighteen patients received intravenous sulbactam alone (1 g every 8 h) and 24 patients received intravenous sulbactam/ampicillin (1 g:2 g every 8 h) with no major adverse effects. Of the 42 patients, 39 improved or were cured and showed A. baumannii eradication and one patient had persistence of wound infection after 8 days of sulbactam/ampicillin requiring surgical debridement. Two patients died after 3 days of therapy (one of the deaths was attributable to A. baumannii infection). The in-vitro activity of the sulbactam/ampicillin combination was by virtue of the antimicrobial activity exhibited by sulbactam. Killing curves showed that sulbactam was bacteriostatic; no synergy was observed between ampicillin and sulbactam. Our results indicate that sulbactam may prove effective for non-life-threatening A. baumannii infections. Its role in the treatment of severe infections is unknown. However, the current formulation of sulbactam alone may allow its use at higher doses and provide new potential synergic combinations, particularly for those infections by A. baumannii resistant to imipenem. (+info)Ampicillin-sulbactam and amoxicillin-clavulanate susceptibility testing of Escherichia coli isolates with different beta-lactam resistance phenotypes. (7/1618)
The activities of ampicillin-sulbactam and amoxicillin-clavulanate were studied with 100 selected clinical Escherichia coli isolates with different beta-lactam susceptibility phenotypes by standard agar dilution and disk diffusion techniques and with a commercial microdilution system (PASCO). A fixed ratio (2:1) and a fixed concentration (clavulanate, 2 and 4 micrograms/ml; sulbactam, 8 micrograms/ml) were used in the agar dilution technique. The resistance frequencies for amoxicillin-clavulanate with different techniques were as follows: fixed ratio agar dilution, 12%; fixed concentration 4-micrograms/ml agar dilution, 17%; fixed ratio microdilution, 9%; and disk diffusion, 9%. Marked discrepancies were found when these results were compared with those obtained with ampicillin-sulbactam (26 to 52% resistance), showing that susceptibility to amoxicillin-clavulanic acid cannot be predicted by testing the isolate against ampicillin-sulbactam. Interestingly, the discrimination between susceptible and intermediate isolates was better achieved with 4 micrograms of clavulanate per ml than with the fixed ratio. In contrast, amoxicillin susceptibility was not sufficiently restored when 2 micrograms of clavulanate per ml was used, particularly in moderate (mean beta-lactamase activity, 50.8 mU/mg of protein) and high-level (215 mU/mg) TEM-1 beta-lactamase producer isolates. Four micrograms of clavulanate per milliliter could be a reasonable alternative to the 2:1 fixed ratio, because most high-level beta-lactamase-hyperproducing isolates would be categorized as nonsusceptible, and low- and moderate-level beta-lactamase-producing isolates would be categorized as nonresistant. This approach cannot be applied to sulbactam, either with the fixed 2:1 ratio or with the 8-micrograms/ml fixed concentration, because many low-level beta-lactamase-producing isolates would be classified in the resistant category. These findings call for a review of breakpoints for beta-lactam-beta-lactamase inhibitors combinations. (+info)Comparison of peritoneal fluid culture results from adults and children undergoing CAPD. (8/1618)
BACKGROUND: Peritonitis is a common complication in patients with end-stage renal disease treated by continuous ambulatory peritoneal dialysis (CAPD). Empirical treatment is based on the organisms that are most frequently isolated and their susceptibilities. OBJECTIVE: To analyze and then compare peritoneal fluid culture results from adult and pediatric patients on CAPD, with respect to micro-organisms and antimicrobial susceptibilities. DESIGN: Three-year retrospective review of peritoneal fluid cultures from adults and children on CAPD. RESULTS: We isolated 481 organisms from 378 peritoneal fluid specimens, collected from 135 patients (45 children, 90 adults). There were 191 episodes of peritonitis in children (mean 4.2+/-3.5, range 1 - 15) compared to 187 in adults (2.1+/-1.9, range 1 - 10) (p< 0.001). Two or more episodes occurred in 30 of 45 children (67%) compared to 33 of 90 adults (37%) (p < 0.001).The number of different organisms/patient as well as the total number of isolates/patient were significantly greater in children (respectively, 2.8+/-2.3, range 1 - 12; and 5.3+/-5.2, range 1 - 27) than in adults (2.0+/-1.3, range 1 - 6; and 2.7+/-2.4, range 1 - 10) (p< 0.005). After Staphylococcus epidermidis, S. aureus was the most frequently isolated organism, occurring in 18% of episodes in adults and 12% of episodes in children (p< 0.01). Twenty-two of 33 fungal isolates (67%) in children were Candida parapsilosis compared to 3 of 24 (12%) in adults (p < 0.001). Subanalysis of multiple episodes revealed that Pseudomonas and Candida occurred significantly more often in children (p< 0.01), whereas S. aureus occurred more often in adults (p< 0.001). In polymicrobial episodes S. epidermidis occurred more often in adults (p < 0.05). Significant differences in susceptibilities to ampicillin, ceftriaxone, chloramphenicol, and gentamicin were found between children and adults (p< 0.05 - 0.001). CONCLUSIONS: CAPD-associated peritonitis occurs significantly more often in children than adults. Significant differences in microbial etiology and susceptibilities were found between pediatric and adult patients. Each dialysis unit should periodically analyze peritoneal fluid culture results from its CAPD patients. These data can then be used for optimization of empirical antimicrobial therapy of peritonitis. (+info)
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As a derivative of ampicillin, amoxicillin is a member of the penicillin family and, like penicillins, is a β-lactam antibiotic ... When there is an adequate response to ampicillin, the course of antibiotic therapy may often be completed with oral amoxicillin ... It became available in 1972 and was the second aminopenicillin to reach the market (after ampicillin in 1961). Co-amoxiclav ... Some studies indicate about 80-90% of patients with acute Epstein Barr virus infection treated with amoxicillin or ampicillin ...
Production of antibiotics
An example of semi-synthetic production involves the drug ampicillin. A beta lactam antibiotic just like penicillin, ampicillin ... Raynor, B.Denise (1997). "Penicillin and ampicillin". Primary Care Update for OB/GYNS. 4 (4): 147-152. doi:10.1016/s1068-607x( ... This additional amino group gives ampicillin a broader spectrum of use than penicillin. Methicillin is another derivative of ...
Codrug
Sultamicillin - esterified ampicillin/sulbactam. W. M. Lau (2008). "Scope and Limitations of the Co-Drug Approach to Topical ...
Talampicillin
It should be avoided in Liver diseases Ampicillin remains the penicillin of choice for many infections because of its oral ... One synthesis involved protecting the primary amino group of ampicillin (1) as the enamine with ethyl acetoacetate (2). THis ... "Lactol esters of ampicillin". Chemical & Pharmaceutical Bulletin. 24 (1): 102-7. doi:10.1248/cpb.24.102. PMID 1269054. Clayton ...
Austrian syndrome
In a specific case study, a patient who had symptoms of a fever and headache was treated with cefotaxime, ampicillin, and ... ". "Ampicillin Uses, Side Effects & Warnings". Munoz, P.; Sainz, J.; Rodriguez-Creixems, M.; Santos, J.; Alcala, L.; Bouza, E ...
Sultamicillin
It contains esterified ampicillin and sulbactam. Sultamicillin is better absorbed from the gut than ampicillin/sulbactam, ... Ampicillin and sulbactam are linked via a methylene group, forming two ester bonds (or more accurately acylal bonds). ... Both drugs are mainly eliminated via the kidneys: within eight hours after intake, 46 to 80% of the ampicillin and 41 to 66% of ... After oral intake, it is absorbed and hydrolytically cleaved to ampicillin and sulbactam by enzymes in the gut wall. These two ...
Providencia (bacterium)
Some strains are sensitive to ampicillin.[citation needed] Adeolu, M.; et al. (2016). "Genome based phylogeny and taxonomy of ...
Large intestine
Smithivas, T.; Hyams, P. J.; Rahal, J. J. (1971-12-01). "Gentamicin and ampicillin in human bile". The Journal of Infectious ...
Antibiotic use in dentistry
Amoxicillin is a derivative of ampicillin. In Dentistry, Ampicillin is sometimes used when dealing with dentoalveolar ... Ampicillin and amoxicillin: These antibiotics are a part of the penicillin group of antibiotics but are effective against a ... While effective, ampicillin is associated with a higher incidence of drug rashes than penicillin and thus, should not be ...
Listeriosis
Ampicillin generally is considered antibiotic of choice; gentamicin is added frequently for its synergistic effects. Overall ... Treatment includes prolonged administration of antibiotics, primarily ampicillin and gentamicin, to which the organism is ...
Defiance (2008 film)
The mention of ampicillin is an anachronism. In one scene it is stated that there may be an epidemic of typhus, and that ... ampicillin (which was not discovered until 1958) is needed. Defiance made $128,000 during its two weeks of limited release in ...
Clostridial necrotizing enteritis
Ampicillin plus gentamicin (or amikacin) plus clindamycin •Ampicillin plus an expanded-spectrum cephalosporin (eg, cefotaxime [ ... replacing ampicillin or added to monotherapy) in centers where there is a high prevalence of methicillin-resistant ... Staphylococcus aureus (MRSA) or ampicillin-resistant enterococcal infections. Centers with significant gentamicin resistance ... Ampicillin plus gentamicin (or amikacin) plus metronidazole • ...
Hetacillin
As opposed to ampicillin, hetacillin is only marginally broken down by the bacterial enzyme beta-lactamase, at least in vitro ... It is a prodrug and has no antibacterial activity itself, but quickly splits off acetone in the human body to form ampicillin, ... Hetacillin was withdrawn from the market for human use when the discovery was made that it had no advantages over ampicillin. ... Hetacillin is prepared from ampicillin and acetone. In aqueous solutions it is unstable, with a half life of 15 to 30 minutes ...
Pivampicillin
It is a prodrug, which is thought to enhance the oral bioavailability of ampicillin because of its greater lipophilicity ... compared to that of ampicillin. Prodrugs that release pivalic acid when broken down by the body-such as pivampicillin, ... Pivampicillin is a pivaloyloxymethyl ester of ampicillin. ...
Surface-enhanced Raman spectroscopy
Andreou, C.; Mirsafavi, R.; Moskovits, M.; Meinhart, C. D. (2015). "Detection of low concentrations of ampicillin in milk". The ...
History of penicillin
The first major development was ampicillin in 1961. It was produced by Beecham Research Laboratories in London. It was more ... "Pharmacology and chemotherapy of ampicillin--a new broad-spectrum penicillin". British Journal of Pharmacology and Chemotherapy ...
Flucloxacillin
... is combined with ampicillin in co-fluampicil. Flucloxacillin powder for oral solution 125 mg/5ml, with measuring ... spoon Selection of Flucloxacillin preparations found in the UK Co-fluampicil: Flucloxacillin combined with ampicillin (UK) " ...
Campylobacteriosis
Trimethoprim/sulfamethoxazole and ampicillin are ineffective against Campylobacter.[citation needed] In the past, poultry ...
Pamoic acid
1272/2008" (04-2019) Saesmaa, T; Tötterman, AM (1990). "Dissolution studies on ampicillin embonate and amoxycillin embonate". ...
PBR322
I. Ampicillin-resistant derivatives of the plasmid pMB9". Gene. 2 (2): 75-93. doi:10.1016/0378-1119(77)90074-9. PMID 344136. ... Another plasmid, RSF 2124, which is a derivative of ColE1, confers ampicillin resistance but is larger. Many other plasmids ... the ampicillin resistance gene of RSF 2124, and the replication elements of pMB1, a close relative of the ColE1 plasmid. A ... resistance to ampicillin .The same process of Insertional Inactivation can be applied to Tetracycline. The AmpR gene is ...
The RNAi Consortium
It contains resistance genes against ampicillin and puromycin. Release 1 of the TRC lentiviral shRNA libraries consist of about ...
Penicillin
Ampicillin Amoxicillin There are many ampicillin precursors in existence. These are inactive compounds that are broken down in ... None of these pro-drugs of ampicillin are in current use: Pivampicillin (pivaloyloxymethyl ester of ampicillin) Bacampicillin ... For instance, penicillin G is large and enters through porins slowly; while smaller ampicillin and amoxicillin diffuse much ... Metampicillin (formaldehyde ester of ampicillin) Talampicillin Hetacillin (ampicillin conjugated to acetone) Epicillin is an ...
Achromobacter xylosoxidans
Ampicillin and carbenicillin, which are penicillins, are an exception. It is variably susceptible to tetracyclines, ...
Pelvic inflammatory disease
An alternative parenteral regimen is ampicillin/sulbactam plus doxycycline. Erythromycin-based medications can also be used. A ...
Tubal factor infertility
An alternative parenteral regimen is ampicillin/sulbactam plus doxycycline. Once infection has been eliminated, surgery may be ...
Bacampicillin
It is a prodrug of ampicillin with improved oral bioavailability. It was sold under the brand names Spectrobid (Pfizer) and ... Many devices have been employed in order to enhance still further the oral absorption of ampicillin. Bacampicillin is a prodrug ... The drug is rapidly absorbed from the gastrointestinal tract and is quickly cleaved by serum esterases to bioactive ampicillin ... The relatively small chemical difference between ampicillin and benzylpenicillin not only allows for substantial oral activity ...
Ciclacillin
Its spectrum of activity is similar to that of ampicillin, although it is less susceptible to beta-lactamases than ampicillin ... In an attempt to form orally active penicillins unrelated to ampicillin, use was made of the fact that certain spiro α-amino ... Gold JA, Hegarty CP, Deitch MW, Walker BR (January 1979). "Double-blind clinical trials of oral cyclacillin and ampicillin". ... in 1978 also showed that ciclacillin is associated with significantly fewer and milder adverse effects than ampicillin; later ...
Micronization
Esfandiari, Nadia; Ghoreishi, Seyyed M. (2015-12-01). "Ampicillin Nanoparticles Production via Supercritical CO2 Gas ...
Minocycline
Nonaka K, Nakazawa Y, Kotorii T (December 1983). "Effects of antibiotics, minocycline and ampicillin, on human sleep". Brain ...
Ampicillin: MedlinePlus Drug Information
Ampicillin: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Take ampicillin until you finish the prescription, even if you feel better. If you stop taking ampicillin too soon or skip ... Before taking ampicillin,. *tell your doctor and pharmacist if you are allergic to ampicillin; penicillins; cephalosporin ... Ampicillin comes as a capsule and a suspension (liquid) to take by mouth. It is usually taken three to four times a day, either ...
Ampicillin and Chloramphenicol Resistance in Systemic
Haemophilus influenzae Disease
... ampicillin and chloramphenicol--is warranted. However, the substantial rise in prevalence of ampicillin resistance in the past ... of all isolates from reported cases tested for ampicillin susceptibility. Ampicillin resistance among HI isolates from reported ... Ampicillin and Chloramphenicol Resistance in Systemic Haemophilus influenzae Disease In late August 1983, a 19-month-old girl ... Since ampicillin-resistant isolates of Hib were first recognized in 1974, resistant strains have become increasingly prevalent ...
Comparison of Ceftriaxone and Ampicillin/Sulbactam for CAP
CTRX Ceftriaxone, ABPC/SBT Ampicillin/sulbactam, CI Confidence interval, EOT End of treatment, EOS End of study. Relapse was ... CTRX Ceftriaxone, ABPC/SBT Ampicillin/sulbactam, CRP C-reactive protein, WBC White blood cell. Data are presented as mean ± ... CTRX Ceftriaxone, ABPC/SBT Ampicillin/sulbactam, CRP C-reactive protein, WBC White blood cell. Data are presented as mean ± ... CTRX Ceftriaxone, ABPC/SBT Ampicillin/sulbactam, MSSA Methicillin-sensitive Staphylococcus aureus. The number of cases with ...
Ampicillin for Injection, USP
Each Ampicillin for Injection Pharmacy Bulk Package contains ampicillin sodium equivalent to 10 grams of ampicillin. ... AMPICILLIN SODIUM (UNII: JFN36L5S8K) (AMPICILLIN - UNII:7C782967RD) AMPICILLIN. 10 g in 100 mL. ... The 10 mcg ampicillin disk and the standard ampicillin powder should provide respectively the following zone diameters and MIC ... Each vial of Ampicillin for Injection, USP Pharmacy Bulk Package contains ampicillin sodium equivalent to 10 grams of ...
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Ampicillin
... Drug Information. Ampicillin is used to treat diseases caused by bacterial infections; it is a type of antibiotic ... Controlled studies with amoxicillin, an antibiotic similar to ampicillin, have shown that a diet low in fiber (7 g/day) ... Consequently, people taking ampicillin might experience fewer episodes of diarrhea if they eat a diet low in indigestible ... Ampicillin blocks this process, which may result in increased undigested carbohydrates in the intestine, increased water in the ...
Ceftriaxone versus ampicillin/cloxacillin as antibiotic prophylaxis in elective caesarean section
... View/. Open. 10_3_2004_277_ ... Ahmed, E.T.S., Mirghani, O.A., Gerais, A.S. & Adam, I. (2004). Ceftriaxone versus ampicillin/cloxacillin as antibiotic ... One dose of ceftriaxone was as effective as ampicillin/ cloxacillin in preventing post-caesarean section complications and is ... Two hundred patients randomly received either ceftriaxone [single dose] or ampicillin/cloxacillin [3 doses] intravenously ...
Cook Children's Health Library - Ampicillin - Drug Database - 674139
Take ampicillin until you finish the prescription, even if you feel better. If you stop taking ampicillin too soon or skip ... Before taking ampicillin, *tell your doctor and pharmacist if you are allergic to ampicillin; penicillins; cephalosporin ... Ampicillin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *diarrhea ... If you experience any of the following symptoms, stop taking ampicillin and call your doctor immediately or get emergency ...
Ampicillin and Sulbactam Drug Information - Indications, Dosage, Side Effects and Precautions
Sulbactam blocks the enzyme, which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria. ... Ampicillin and Sulbactam(Unasyn) generic is a penicillin antibiotic, prescribed for susceptible bacterial infections like skin ... Information about Ampicillin and Sulbactam. Generic Name : Ampicillin and Sulbactam Pronunciation : am- pi- sill in- sul- bak ... What is the dosage of Ampicillin and Sulbactam?. Dose is based on ampicillin dose. IV Endocarditis 2g 6 hourly for 4-6 week ...
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Ceftriaxone7
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Bacteria11
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Antibiotics2
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20211
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