Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Nonsusceptibility of a microbe to the action of ampicillin, a penicillin derivative that interferes with cell wall synthesis.
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
Substances that reduce the growth or reproduction of BACTERIA.
Pivalate ester analog of AMPICILLIN.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Nonsusceptibility of an organism to the action of penicillins.
A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
A species of gram-positive, coccoid bacteria whose organisms are normal flora of the intestinal tract. Unlike ENTEROCOCCUS FAECALIS, this species may produce an alpha-hemolytic reaction on blood agar and is unable to utilize pyruvic acid as an energy source.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
DYSENTERY caused by gram-negative rod-shaped enteric bacteria (ENTEROBACTERIACEAE), most often by the genus SHIGELLA. Shigella dysentery, Shigellosis, is classified into subgroups according to syndrome severity and the infectious species. Group A: SHIGELLA DYSENTERIAE (severest); Group B: SHIGELLA FLEXNERI; Group C: SHIGELLA BOYDII; and Group D: SHIGELLA SONNEI (mildest).
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
An ester of AMPICILLIN which is readily hydrolyzed on absorption to release ampicillin. It is well absorbed from the gastrointestinal tract resulting in a greater bioavailability of ampicillin than can be achieved with equivalent doses of ampicillin.
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
A cephalosporin antibiotic.
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that ferments sugar without gas production. Its organisms are intestinal pathogens of man and other primates and cause bacillary dysentery (DYSENTERY, BACILLARY).
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.
A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.
Infections with bacteria of the genus HAEMOPHILUS.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.
A genus of gram-positive, coccoid bacteria consisting of organisms causing variable hemolysis that are normal flora of the intestinal tract. Previously thought to be a member of the genus STREPTOCOCCUS, it is now recognized as a separate genus.
A lactose-fermenting bacterium causing dysentery.
A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
A cephalosporin antibiotic.
Infections with bacteria of the genus SALMONELLA.
Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.
Nonsusceptibility of bacteria to the action of CHLORAMPHENICOL, a potent inhibitor of protein synthesis in the 50S ribosomal subunit where amino acids are added to nascent bacterial polypeptides.
Semisynthetic broad-spectrum cephalosporin.
Therapy with two or more separate preparations given for a combined effect.
Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.
A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Inflammation of the meninges caused by LISTERIA MONOCYTOGENES infection, usually occurring in individuals under the age of 3 years or over the age of 50 years. It may occur at any age in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. Clinical manifestations include FEVER, altered mentation, HEADACHE, meningeal signs, focal neurologic signs, and SEIZURES. (From Medicine 1998 Sep;77(5):313-36)
Infections with bacteria of the species ESCHERICHIA COLI.
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
A serotype of SALMONELLA ENTERICA which is the etiologic agent of TYPHOID FEVER.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A broad-spectrum antimicrobial carboxyfluoroquinoline.
Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.
An acute systemic febrile infection caused by SALMONELLA TYPHI, a serotype of SALMONELLA ENTERICA.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.
Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.
The action of a drug in promoting or enhancing the effectiveness of another drug.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is extremely pathogenic and causes severe dysentery. Infection with this organism often leads to ulceration of the intestinal epithelium.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Enzyme which catalyzes the peptide cross-linking of nascent CELL WALL; PEPTIDOGLYCAN.
Vertical transmission of hereditary characters by DNA from cytoplasmic organelles such as MITOCHONDRIA; CHLOROPLASTS; and PLASTIDS, or from PLASMIDS or viral episomal DNA.
An amidinopenicillanic acid derivative with broad spectrum antibacterial action.
Infections by bacteria, general or unspecified.
A genus of gram-positive, anaerobic bacteria whose organisms divide in three perpendicular planes and occur in packets of eight or more cells. It has been isolated from soil, grains, and clinical specimens.
A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases.
A genus of gram-negative, rod-shaped enterobacteria that can use citrate as the sole source of carbon.
A genus of PASTEURELLACEAE that consists of several species occurring in animals and humans. Its organisms are described as gram-negative, facultatively anaerobic, coccobacillus or rod-shaped, and nonmotile.
Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.
A subgenus of Salmonella containing several medically important serotypes. The habitat for the majority of strains is warm-blooded animals.
DNA elements that include the component genes and insertion site for a site-specific recombination system that enables them to capture mobile gene cassettes.
Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE.
A group of compounds having the general formula CH2=C(CN)-COOR; it polymerizes on contact with moisture; used as tissue adhesive; higher homologs have hemostatic and antibacterial properties.
Infections with bacteria of the genus STREPTOCOCCUS.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
Simultaneous resistance to several structurally and functionally distinct drugs.
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-.
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.

Serum ampicillin levels in the calf: influence of dosage, route of administration and dosage form. (1/1618)

Holstein bull calves received ampicillin sodium by the intravenous, intramuscular and subcutaneous routes and ampicillin trihydrate by the intramuscular route, at a dosage of 5 mg/kg. In addition ampicillin sodium and ampicillin trihydrate were given at a 12 mg/kg dosage intramuscularly. The serum ampicillin concentrations were determined at five, 30, 60, 120, 180, 240 and 300 min after drug administration and at 360 min after ampicillin trihydrate injection. Intravenous administration gave a high initial level (16.2 mug/ml) at five min that declined to below 1 mug/ml by 120 min. Subcutaneous administration produced the lowest initial levels of drug but concentrations of drug detected did not differ significantly from the intramuscular administration at any sampling interval. The 12 mg/kg intramuscular ampicillin sodium dosage produced significantly higher levels than the 5 mg/kg dosage only at five min. Ampicillin trihydrate gave higher levels than ampicillin sodium at all times except 30 min (5 mg/kg) and five min (12 mg/kg). The serum ampicillin disappearance study (5 mg/kg intravenous) gave a two component bi-exponential curve. Kinetic analysis of the first component showed a C01 (theoretical initial conc) of 44.8 mug/ml, a ke1 (rate constant of disappearance) of 0.064 mug min and a t1/21 (calculated half-life) of 10.8 min. The Co2, ke2 and t1/22 of the second component were 6.2 mug/ml, 0.0157 mug/min and 46.2 min respectively.  (+info)

A case of canine salmonellosis due to Salmonella infantis. (2/1618)

A 7-year-old male dog kept outdoors manifested severe watery diarrhea with generalized weakness. Salmonella Infantis was isolated from a fecal sample and the dog recovered soon after medication with ampicillin, to which the isolate was highly sensitive. The present case was diagnosed as S. Infantis infection. Due to the importance of Salmonella in public health, soil samples were collected from the garden where the dog was kept and were examined for Salmonella, Some of them were positive for S. Infantis, however, no Salmonella was isolated from any soil samples collected after thorough disinfection of the surrounded environment.  (+info)

Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides. (3/1618)

The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone combinations for 10 Enterococcus faecalis strains with high-level resistance to aminoglycosides (HLRAg) and to assess the efficacy of ampicillin plus ceftriaxone, both administered with humanlike pharmacokinetics, for the treatment of experimental endocarditis due to HLRAg E. faecalis. A reduction of 1 to 4 dilutions in MICs of ampicillin was obtained when ampicillin was combined with a fixed subinhibitory ceftriaxone concentration of 4 micrograms/ml. This potentiating effect was also observed by the double disk method with all 10 strains. Time-kill studies performed with 1 and 2 micrograms of ampicillin alone per ml or in combination with 5, 10, 20, 40, and 60 micrograms of ceftriaxone per ml showed a > or = 2 log10 reduction in CFU per milliliter with respect to ampicillin alone and to the initial inoculum for all 10 E. faecalis strains studied. This effect was obtained for seven strains with the combination of 2 micrograms of ampicillin per ml plus 10 micrograms of ceftriaxone per ml and for six strains with 5 micrograms of ceftriaxone per ml. Animals with catheter-induced endocarditis were infected intravenously with 10(8) CFU of E. faecalis V48 or 10(5) CFU of E. faecalis V45 and were treated for 3 days with humanlike pharmacokinetics of 2 g of ampicillin every 4 h, alone or combined with 2 g of ceftriaxone every 12 h. The levels in serum and the pharmacokinetic parameters of the humanlike pharmacokinetics of ampicillin or ceftriaxone in rabbits were similar to those found in humans treated with 2 g of ampicillin or ceftriaxone intravenously. Results of the therapy for experimental endocarditis caused by E. faecalis V48 or V45 showed that the residual bacterial titers in aortic valve vegetations were significantly lower in the animals treated with the combinations of ampicillin plus ceftriaxone than in those treated with ampicillin alone (P < 0.001). The combination of ampicillin and ceftriaxone showed in vitro and in vivo synergism against HLRAg E. faecalis.  (+info)

Pharmacodynamic comparisons of levofloxacin, ciprofloxacin, and ampicillin against Streptococcus pneumoniae in an in vitro model of infection. (4/1618)

The increasing frequency of penicillin-resistant pneumococcus continues to be of concern throughout the world. Newer fluoroquinolone antibiotics, such as levofloxacin, have shown enhanced in vitro activity against Streptococcus pneumoniae. In this study, the bactericidal characteristics and pharmacodynamic profiles of levofloxacin, ciprofloxacin, and ampicillin against four isolates of S. pneumoniae were compared by using an in vitro model of infection. Standard antibiotic dosing regimens which simulated the pharmacokinetic profile observed in humans were used. Control and treatment models were sampled for bacterial CFU per milliliter over the duration of each 24- or 48-h experiment. In addition, treatment models were sampled for MIC determinations and drug concentration. Regrowth of all isolates as well as an increase in MICs throughout the study period was observed in the ciprofloxacin experiments. A limited amount of regrowth was noted during levofloxacin therapy for one isolate; however, no change in MIC was detected for any isolate. Ampicillin showed rapid and sustained bactericidal activity against all isolates. In this study, ratios of effective fluoroquinolone area under the concentration-time curve (AUC):MIC values ranged from 30 to 55. Levofloxacin, owing to its larger AUC0-24 values, has excellent and sustained activity against different pneumococcal strains superior to that of ciprofloxacin.  (+info)

Evaluation of bactericidal activities of LY333328, vancomycin, teicoplanin, ampicillin-sulbactam, trovafloxacin, and RP59500 alone or in combination with rifampin or gentamicin against different strains of vancomycin-intermediate Staphylococcus aureus by time-kill curve methods. (5/1618)

This in vitro study evaluated the activities of vancomycin, LY333328, and teicoplanin alone and in combination with gentamicin, rifampin, and RP59500 against Staphylococcus aureus isolates with intermediate susceptibilities to vancomycin. Ampicillin-sulbactam and trovafloxacin were also evaluated. LY333328 and ampicillin-sulbactam resulted in bactericidal activity against all isolates. The combination of gentamicin with glycopeptides showed synergistic activity, while rifampin had no added benefit.  (+info)

Efficacy of sulbactam alone and in combination with ampicillin in nosocomial infections caused by multiresistant Acinetobacter baumannii. (6/1618)

From March 1995 to March 1997, sulbactam was prospectively evaluated in patients with non-life-threatening multiresistant Acinetobacter baumannii infections. During this period, 47 patients were treated with sulbactam; of them, five were excluded because they had received < or =48 h of sulbactam therapy. A total of 42 patients, 27 males and 15 females with a mean age of 60+/-15 years, were finally evaluated. Infections were as follows: surgical wound, 19; tracheobronchitis, 12; urinary tract, 7; catheter-related bacteraemia, 2; and pneumonia, 2. Eighteen patients received intravenous sulbactam alone (1 g every 8 h) and 24 patients received intravenous sulbactam/ampicillin (1 g:2 g every 8 h) with no major adverse effects. Of the 42 patients, 39 improved or were cured and showed A. baumannii eradication and one patient had persistence of wound infection after 8 days of sulbactam/ampicillin requiring surgical debridement. Two patients died after 3 days of therapy (one of the deaths was attributable to A. baumannii infection). The in-vitro activity of the sulbactam/ampicillin combination was by virtue of the antimicrobial activity exhibited by sulbactam. Killing curves showed that sulbactam was bacteriostatic; no synergy was observed between ampicillin and sulbactam. Our results indicate that sulbactam may prove effective for non-life-threatening A. baumannii infections. Its role in the treatment of severe infections is unknown. However, the current formulation of sulbactam alone may allow its use at higher doses and provide new potential synergic combinations, particularly for those infections by A. baumannii resistant to imipenem.  (+info)

Ampicillin-sulbactam and amoxicillin-clavulanate susceptibility testing of Escherichia coli isolates with different beta-lactam resistance phenotypes. (7/1618)

The activities of ampicillin-sulbactam and amoxicillin-clavulanate were studied with 100 selected clinical Escherichia coli isolates with different beta-lactam susceptibility phenotypes by standard agar dilution and disk diffusion techniques and with a commercial microdilution system (PASCO). A fixed ratio (2:1) and a fixed concentration (clavulanate, 2 and 4 micrograms/ml; sulbactam, 8 micrograms/ml) were used in the agar dilution technique. The resistance frequencies for amoxicillin-clavulanate with different techniques were as follows: fixed ratio agar dilution, 12%; fixed concentration 4-micrograms/ml agar dilution, 17%; fixed ratio microdilution, 9%; and disk diffusion, 9%. Marked discrepancies were found when these results were compared with those obtained with ampicillin-sulbactam (26 to 52% resistance), showing that susceptibility to amoxicillin-clavulanic acid cannot be predicted by testing the isolate against ampicillin-sulbactam. Interestingly, the discrimination between susceptible and intermediate isolates was better achieved with 4 micrograms of clavulanate per ml than with the fixed ratio. In contrast, amoxicillin susceptibility was not sufficiently restored when 2 micrograms of clavulanate per ml was used, particularly in moderate (mean beta-lactamase activity, 50.8 mU/mg of protein) and high-level (215 mU/mg) TEM-1 beta-lactamase producer isolates. Four micrograms of clavulanate per milliliter could be a reasonable alternative to the 2:1 fixed ratio, because most high-level beta-lactamase-hyperproducing isolates would be categorized as nonsusceptible, and low- and moderate-level beta-lactamase-producing isolates would be categorized as nonresistant. This approach cannot be applied to sulbactam, either with the fixed 2:1 ratio or with the 8-micrograms/ml fixed concentration, because many low-level beta-lactamase-producing isolates would be classified in the resistant category. These findings call for a review of breakpoints for beta-lactam-beta-lactamase inhibitors combinations.  (+info)

Comparison of peritoneal fluid culture results from adults and children undergoing CAPD. (8/1618)

BACKGROUND: Peritonitis is a common complication in patients with end-stage renal disease treated by continuous ambulatory peritoneal dialysis (CAPD). Empirical treatment is based on the organisms that are most frequently isolated and their susceptibilities. OBJECTIVE: To analyze and then compare peritoneal fluid culture results from adult and pediatric patients on CAPD, with respect to micro-organisms and antimicrobial susceptibilities. DESIGN: Three-year retrospective review of peritoneal fluid cultures from adults and children on CAPD. RESULTS: We isolated 481 organisms from 378 peritoneal fluid specimens, collected from 135 patients (45 children, 90 adults). There were 191 episodes of peritonitis in children (mean 4.2+/-3.5, range 1 - 15) compared to 187 in adults (2.1+/-1.9, range 1 - 10) (p< 0.001). Two or more episodes occurred in 30 of 45 children (67%) compared to 33 of 90 adults (37%) (p < 0.001).The number of different organisms/patient as well as the total number of isolates/patient were significantly greater in children (respectively, 2.8+/-2.3, range 1 - 12; and 5.3+/-5.2, range 1 - 27) than in adults (2.0+/-1.3, range 1 - 6; and 2.7+/-2.4, range 1 - 10) (p< 0.005). After Staphylococcus epidermidis, S. aureus was the most frequently isolated organism, occurring in 18% of episodes in adults and 12% of episodes in children (p< 0.01). Twenty-two of 33 fungal isolates (67%) in children were Candida parapsilosis compared to 3 of 24 (12%) in adults (p < 0.001). Subanalysis of multiple episodes revealed that Pseudomonas and Candida occurred significantly more often in children (p< 0.01), whereas S. aureus occurred more often in adults (p< 0.001). In polymicrobial episodes S. epidermidis occurred more often in adults (p < 0.05). Significant differences in susceptibilities to ampicillin, ceftriaxone, chloramphenicol, and gentamicin were found between children and adults (p< 0.05 - 0.001). CONCLUSIONS: CAPD-associated peritonitis occurs significantly more often in children than adults. Significant differences in microbial etiology and susceptibilities were found between pediatric and adult patients. Each dialysis unit should periodically analyze peritoneal fluid culture results from its CAPD patients. These data can then be used for optimization of empirical antimicrobial therapy of peritonitis.  (+info)

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1980 March; 17(3): 359-63. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=6903434 • Bacteriology of 100 consecutive diabetic foot infections and in vitro susceptibility to ampicillin/sulbactam versus cefoxitin. Author(s): Borrero E, Rossini M Jr. Source: Angiology. 1992 April; 43(4): 357-61. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=1558322 • Bacteriology of chronic sinusitis after ampicillin therapy. Author(s): Jiang RS, Hsu CY. Source: American Journal of Rhinology. 1997 November-December; 11(6): 467-71. Cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=9571747 • High-performance liquid chromatographic assay of ampicillin and its prodrug lenampicillin. Author(s): Marzo A, Monti N, Ripamonti M, Arrigoni Martelli E, Picari M. Source: Journal of Chromatography. 1990 May 16; 507: 235-9. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=2380291 • High-performance liquid chromatographic assay of ampicillin, amoxicillin and ciclacillin in serum and urine using a pre-column reaction with ...
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This paper utilized a neural network for texture image analysis to differentiate between milk, either raw or ultra high temperature (UHT) with antibiotic residues (e.g., penicillin G and ampicillin) and milk without antibiotic residues. The biocrystallization method was applied to obtain biocrystallogram images for milk samples spiked with penicillin G and ampicillin at different concentration levels. The biocrystallogram images were used as an input for a designed neural network called the image processing neural network (ImgProcNN). The visual differences in these images that were based on textural properties, including the distribution of crystals on the circular grass underlay, the thin or thick structure of the crystal needles, and the angles between the branches and the side needles, were used to discriminate the antibiotic-free milk samples from samples with antibiotic residues. The visual description and definition of these images have major disadvantages. In this study, the ImgProcNN ...
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Since neonatal sepsis dose not have typical symptoms and signs, whenever suspected antibiotic therapy is the mainstay of treatment. Ampicillin-sulbactam has been widely used in the newborn nursery as the empirical antibiotics as well as ampicillin and gentamicin. The purpose of this study was to compare the efficacy and safety of amoxicillin-sulbactam to ampicillin-sulbactam in treating neonatal sepsis. METHODS: A randomized, controlled study was conducted in 60 full term neonates who were suspected to have sepsis. The patients were randomly assigned to receive amoxicillin-sulbactam 30 mg/kg/day (based on amoxicillin component) intravenously divided every 12 hours or ampicillin-sulbactam 75 mg/kg/day (based on ampicillin component) intravenously divided every 8 hours for at least 7 consecutive days. Clinical symptoms and signs, complete blood cell counts, blood chemistry and body fluid cultures were taken before, during and after the treatment. All patients were evaluated for clinical efficacy ...
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The primary objective of this randomized controlled challenge study was to investigate the effect of ampicillin on ultrasonographic (US) lung consolidation after experimental challenge with Pasteurella multocida in preweaned dairy calves. The secondary objectives were to determine whether ampicillin affected respiratory score, gross consolidation, or the detection of P. multocida in lung tissue at postmortem exam (PME). Holstein bull calves (n = 39) were transported to the University of Wisconsin-Madison School of Veterinary Medicine isolation facility at the mean (±SD) age of 52 ± 6 d. After a 7-d acclimation period, 30 calves were inoculated intratracheally with 1010 cfu of ampicillin-sensitive P. multocida. Lung US and respiratory scoring were performed 2, 6, 12, and 24 h post-challenge, then US once daily and respiratory scoring twice daily until d 14. Calves were randomized to receive ampicillin [n = 17, treatment (TX), 6.6 mg/kg i.m. once daily for 3 d] or placebo [n = 11, control (CON), ...
Cefepime vs. Ampicillin/Sulbactam and Aztreonam as antibiotic prophylaxis in neurosurgical patients with external ventricular drain: result of a prospective randomized controlled clinical trial.
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Antibiotic resistance is a serious public health risk that may spread via potable and reclaimed water. Effective disinfection is important for inactivation of antibiotic-resistant bacteria and disruption of antibiotic resistance genes. Ampicillin is a widely prescribed antibiotic but its effectiveness is increasingly undermined by resistance. In this study, changes in ampicillin resistance for Escherichia coli (E. coli) CGMCC 1.1595 were analyzed after exposure to different doses of ultraviolet (UV) or chlorine, and damage incurred by the plasmid encoding ampicillin resistance gene blaTEM-1 was assessed. We reported a greater stability in ampicillin-resistant E. coli CGMCC 1.1595 after UV irradiation or chlorination when compared with previously published data for other E. coli strains. UV irradiation and chlorination led to a shift in the mortality frequency distributions of ampicillin-resistant E. coli when subsequently exposed to ampicillin. The ampicillin hemi-inhibitory concentration (IC50) ...
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There is an arising and concerning issue in the field of bacterial resistance, which is confirmed by the number of deaths associated with drug-resistant bacterial infections. The aim of this study was to compare the effects of antibiotics on Staphylococcus aureus non-resistant strain and strains resistant to cadmium or lead ions. Metal resistant strains were created by the gradual addition of 2 mM solution of metal ions (cadmium or lead) to the S. aureus culture. An increasing antimicrobial effect of ampicillin, streptomycin, penicillin and tetracycline (0, 10, 25, 50, 75, 150, 225 and 300 µM) on the resistant strains was observed using a method of growth curves. A significant growth inhibition (compared to control) of cadmium resistant cells was observed in the presence of all the four different antibiotics. On the other hand, the addition of streptomycin and ampicillin did not inhibit the growth of lead resistant strain. Other antibiotics were still toxic to the bacterial cells. Significant
X BackgroundTo devise treatment strategies for neonatal. for suspected neonatal sepsis was. to ampicillin and gentamicin or.NEONATAL SEPSIS DR. CRISBERT I. CUALTEROS Definition Neonatal sepsis is a clinical syndrome of systemic illness accompanied by bacteremia occurring in the first month.%T Are the Good Old Antibiotics Still Appropriate for Early-Onset Neonatal Sepsis? A 10 Year. resistance to the combination of ampicillin and gentamicin ...
Ampicillin-sulbactam: 1.5 g (1 g ampicillin plus 0.5 g sulbactam) to 3 g (3 g ampicillin plus 1 g sulbactam) intravenous (IV) every 6 hrs or Amoxicillin-clavulanate: 1.2 g (1000 mg amoxicillin plus 200 mg clavulanate) IV every 6 to 8 hrs.. A glycopeptide antibiotic (either vancomycin 1 g IV every 12 hrs or teicoplanin IV loading dose of 400 mg the first day followed by a maintenance dose of 200 mg daily) may be added to the aminopenicillin/betalactamase inhibitor regimen if infection with methicillin-resistant staphylococcus aureus (MRSA) is suspected or confirmed within the first 72 hrs of enrollment. If culture results fail to show a resistant organism, use of the glycopeptide may be discontinued. ...
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Hi everybody Lately we have been having hard time with ampicillin plates in our lab. I cant figure out what were doing wrong: we prepare stock solution of 100 mg/ml ampicillin in water, and add them to LB medium just before we pour the plates (not too hot) to a concentration of 100 or 150 ug/ml. Alas, there is a major problem of satelite colonies growing around the resistant colonies when we spread-plate transformation mixtures. Any idea? Thanks for any input PS It would be best if you could cc your reply to my email, so I wont miss a reply. ________________________________________________________________________ Ron Caspi Scripps Institution of Oceanography Phone (619) 534-0638 La Jolla CA 92093-0202 Fax (619) 534-7313 ...
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As a derivative of ampicillin, amoxicillin is a member of the penicillin family and, like penicillins, is a β-lactam antibiotic ... When there is an adequate response to ampicillin, the course of antibiotic therapy may often be completed with oral amoxicillin ... It became available in 1972 and was the second aminopenicillin to reach the market (after ampicillin in 1961). Co-amoxiclav ... Some studies indicate about 80-90% of patients with acute Epstein Barr virus infection treated with amoxicillin or ampicillin ...
However, when Penbritin (ampicillin) came on the market in 1961, Beecham's facilities were soon inadequate for the worldwide ...
An example of semi-synthetic production involves the drug ampicillin. A beta lactam antibiotic just like penicillin, ampicillin ... Raynor, B.Denise (1997). "Penicillin and ampicillin". Primary Care Update for OB/GYNS. 4 (4): 147-152. doi:10.1016/s1068-607x( ... This additional amino group gives ampicillin a broader spectrum of use than penicillin. Methicillin is another derivative of ...
It should be avoided in Liver diseases Ampicillin remains the penicillin of choice for many infections because of its oral ... One synthesis involved protecting the primary amino group of ampicillin (1) as the enamine with ethyl acetoacetate (2). THis ... "Lactol esters of ampicillin". Chemical & Pharmaceutical Bulletin. 24 (1): 102-7. doi:10.1248/cpb.24.102. PMID 1269054. Clayton ...
It contains esterified ampicillin and sulbactam. Sultamicillin is better absorbed from the gut than ampicillin/sulbactam, ... Ampicillin and sulbactam are linked via a methylene group, forming two ester bonds (or more accurately acylal bonds). ... Both drugs are mainly eliminated via the kidneys: within eight hours after intake, 46 to 80% of the ampicillin and 41 to 66% of ... After oral intake, it is absorbed and hydrolytically cleaved to ampicillin and sulbactam by enzymes in the gut wall. These two ...
Some strains are sensitive to ampicillin.[citation needed] Adeolu, M.; et al. (2016). "Genome based phylogeny and taxonomy of ...
Smithivas, T.; Hyams, P. J.; Rahal, J. J. (1971-12-01). "Gentamicin and ampicillin in human bile". The Journal of Infectious ...
Sultamicillin, which is esterified ampicillin/sulbactam. W. M. Lau (2008). "Scope and Limitations of the Co-Drug Approach to ...
Some strains are sensitive to ampicillin.[citation needed]. References[edit]. *^ Stuart, CA; Wheeler, KM; Rustigian, R; ...
Ampicillin generally is considered antibiotic of choice; gentamicin is added frequently for its synergistic effects. Overall ... Treatment includes prolonged administration of antibiotics, primarily ampicillin and gentamicin, to which the organism is ...
It is a prodrug, which is thought to enhance the oral bioavailability of ampicillin because of its greater lipophilicity ... compared to that of ampicillin. Prodrugs that release pivalic acid when broken down by the body-such as pivampicillin, ... Pivampicillin is a pivaloyloxymethyl ester of ampicillin. ...
With Th Dimmling: Comparison of two ampicillin preparations juice In: Medicine Vol 69, April 1974 ISSN 0025-8458, pp. 642-645, ...
Andreou, C.; Mirsafavi, R.; Moskovits, M.; Meinhart, C. D. (2015). "Detection of low concentrations of ampicillin in milk". The ...
The first major development was ampicillin in 1961. It was produced by Beecham Research Laboratories in London. It was more ... "Pharmacology and chemotherapy of ampicillin--a new broad-spectrum penicillin". British Journal of Pharmacology and Chemotherapy ...
... is combined with ampicillin in co-fluampicil. Flucloxacillin powder for oral solution 125 mg/5ml, with measuring ... spoon Selection of Flucloxacillin preparations found in the UK Co-fluampicil: Flucloxacillin combined with ampicillin (UK) " ...
Trimethoprim/sulfamethoxazole and ampicillin are ineffective against Campylobacter.[citation needed] In the past, poultry ...
I. Ampicillin-resistant derivatives of the plasmid pMB9". Gene. 2 (2): 75-93. doi:10.1016/0378-1119(77)90074-9. PMID 344136. ... Another plasmid, RSF 2124, which is a derivative of ColE1, confers ampicillin resistance but is larger. Many other plasmids ... the ampicillin resistance gene of RSF 2124, and the replication elements of pMB1, a close relative of the ColE1 plasmid. A ... the gene bla encoding the ampicillin resistance (AmpR) protein, and the gene tetA encoding the tetracycline resistance (TetR) ...
It contains resistance genes against ampicillin and puromycin. Release 1 of the TRC lentiviral shRNA libraries consist of about ...
Ampicillin Amoxycillin There are a number of ampicillin precursors in existence. These are inactive compounds that are broken ... None of these pro-drugs of ampicillin are in current use: Pivampicillin (pivaloyloxymethyl ester of ampicillin) Bacampicillin ... For instance, penicillin G is large and enters through porins slowly; while smaller ampicillin and amoxicillin diffuse much ... Metampicillin (formaldehyde ester of ampicillin) Talampicillin Hetacillin (ampicillin conjugated to acetone) Epicillin is an ...
In one scene it is stated that there may be an epidemic of typhus, and that ampicillin (which was not discovered until 1958) is ... The mention of ampicillin is an anachronism. ...
Ampicillin and carbenicillin, which are penicillins, are an exception. It is variably susceptible to tetracyclines, ...
An alternative parenteral regimen is ampicillin/sulbactam plus doxycycline. Erythromycin-based medications can also be used. A ...
An alternative parenteral regimen is ampicillin/sulbactam plus doxycycline. Once infection has been eliminated, surgery may be ...
It is a prodrug of ampicillin with improved oral bioavailability. It is sold under the brand names Spectrobid (Pfizer) and ... Many devices have been employed in order to enhance still further the oral absorption of ampicillin. Bacampicillin is a prodrug ... The drug is rapidly absorbed from the gastrointestinal tract and is quickly cleaved by serum esterases to bioactive ampicillin ... The relatively small chemical difference between ampicillin and benzylpenicillin not only allows for substantial oral activity ...
Its spectrum of activity is similar to that of ampicillin, although it is less susceptible to beta-lactamases than ampicillin ... In an attempt to form orally active penicillins unrelated to ampicillin, use was made of the fact that certain spiro α-amino ... Gold JA, Hegarty CP, Deitch MW, Walker BR (January 1979). "Double-blind clinical trials of oral cyclacillin and ampicillin". ... in 1978 also showed that ciclacillin is associated with significantly fewer and milder adverse effects than ampicillin; later ...
As opposed to ampicillin, hetacillin is only marginally broken down by the bacterial enzyme beta-lactamase, at least in vitro ... Sutherland R, Robinson OP (June 1967). "Laboratory and pharmacological studies in man with hetacillin and ampicillin". British ... but quickly splits off acetone in the human body to form ampicillin, which is active against a variety of bacteria. Hetacillin ... Hetacillin is prepared from ampicillin and acetone. In aqueous solutions it is unstable, with a half life of 15 to 30 minutes ...
Esfandiari, Nadia; Ghoreishi, Seyyed M. (2015-12-01). "Ampicillin Nanoparticles Production via Supercritical CO2 Gas ...
Nonaka K, Nakazawa Y, Kotorii T (December 1983). "Effects of antibiotics, minocycline and ampicillin, on human sleep". Brain ...
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ampicillin (ăm´pĬsĬl´Ĭn), a penicillin [1]-type antibiotic [2] that is effective against both gram-negative microorganisms and ... ampicillin (ăm´pĬsĬl´Ĭn), a penicillin-type antibiotic that is effective against both gram-negative microorganisms and gram- ... ampicillin (am-pi-sil-in) n. a semisynthetic penicillin administered by mouth or injection in the treatment of a variety of ... ampicillin The Oxford Pocket Dictionary of Current English © The Oxford Pocket Dictionary of Current English 2009, originally ...
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Hetacillin and Ampicillin. Br Med J 1967; 3 doi: https://doi.org/10.1136/bmj.3.5567.737 (Published 16 September 1967) Cite this ...
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Find information on Ampicillin in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, ... ampicillin is a topic covered in the Daviss Drug Guide. To view the entire topic, please sign in or purchase a subscription. ... "Ampicillin." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2019. Washington Manual, www.unboundmedicine.com/ ... washingtonmanual/view/Davis-Drug-Guide/51051/all/ampicillin. Quiring C, Sanoski CA, Vallerand AH. Ampicillin. Daviss Drug ...
... special pro-drug of ampicillin) Azlocillin and pirbenicillin (urea and amide made from ampicillin) "Ampicillin - international ... Ampicillin is not recommended in people with concurrent mononucleosis, as over 40% of patients develop a skin rash. Ampicillin ... Ampicillin reacts with probenecid and methotrexate to decrease renal excretion. Large doses of ampicillin can increase the risk ... Ampicillin has been used extensively to treat bacterial infections since 1961. Until the introduction of ampicillin by the ...
Ampicillin is used to treat or prevent many different types of infections such as bladder infections, pneumonia, gonorrhea, ... Ampicillin may also be used for purposes not listed in this medication guide. ... Ampicillin is a penicillin antibiotic that fights bacteria. ... Ampicillin 250 mg-STA. slide 1 of 6, Ampicillin 250 mg-STA, ... What is ampicillin?. Ampicillin is a penicillin antibiotic that fights bacteria.. Ampicillin is used to treat or prevent many ...
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... Douglas D. Glover,1,2 David Lalka,2 and Gilles R. G. Monif3 ... The pharmacokinetics of penicillin G and ampicillin are reviewed as they pertain to their potential use in in vitro therapy. ...
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  • also available as ampicillin sodium and ampicillin trihydrate. (scitoys.com)
  • Ampicillin trihydrate is a semisynthetic penicillin derived from the basic penicillin nucleus, 6-aminopenicillanic acid. (nih.gov)
  • Ampicillin is designed chemically as (2S, 5R, 6R)-6-[(R)-2-Amino-2-phenylacetamido]-3, 3-dimethyl-7-oxo-4-this-l-azabicyclo[3.2.0]heptane-2-carbxylic acid trihydrate. (nih.gov)
  • Ampicillin Capsules, USP for oral administration provides ampicillin trihydrate equivalent to 250 mg and 500 mg ampicillin. (nih.gov)
  • The prevalence of allergic disease of the respiratory tract and skin among Russian workers engaged in the production of ampicillin trihydrate and ampicillin sodium salt has been investigated (Karpenko, 1986). (europa.eu)
  • Ampicillin trihydrate injection is given under the skin or into the muscle, but should NOT be given into the vein, as this can cause sudden death. (vcahospitals.com)
  • Hi all, I am trying to dissolve ampicillin trihydrate in distilled water at a concentration of 50mg/ml. (protocol-online.org)
  • Friend, your ampicillin trihydrate is only slightly soluble in water, and practically insoluble in alcohol and in fatty oils. (protocol-online.org)
  • Ampicillin Trihydrate Market Report provides an analytical assessment of the prime challenges faced by this Market currently and in the coming years, which helps Market participants in understanding the problems they may face while operating in this Market over a longer period of time. (beforeitsnews.com)
  • Various policies and news are also included in the Ampicillin Trihydrate Market report. (beforeitsnews.com)
  • Various costs involved in the production of Ampicillin Trihydrate are discussed further. (beforeitsnews.com)
  • This provides the basic information about the Ampicillin Trihydrate industry. (beforeitsnews.com)
  • Production Analysis- Production of the Ampicillin Trihydrate is analysed with respect to different regions, types and applications. (beforeitsnews.com)
  • Here, price analysis of various Ampicillin Trihydrate Market key players is also covered. (beforeitsnews.com)
  • Sales and Revenue Analysis- Both, sales and revenue are studied for the different regions of the global Ampicillin Trihydrate Market. (beforeitsnews.com)
  • Supply and Consumption- In continuation with sales, this section studies supply and consumption for the Ampicillin Trihydrate Market. (beforeitsnews.com)
  • Competitors- In this section, various Ampicillin Trihydrate industry leading players are studied with respect to their company profile, product portfolio, capacity, price, cost and revenue. (beforeitsnews.com)
  • Other analyses- Apart from the aforementioned information, trade and distribution analysis for the Ampicillin Trihydrate Market, contact information of major manufacturers, suppliers and key consumers is also given. (beforeitsnews.com)
  • The Ampicillin Trihydrate Market for major regions is given. (beforeitsnews.com)
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  • Like other penicillin antibiotics, ampicillin acts against bacteria by inhibiting the synthesis of bacterial cell wall components. (encyclopedia.com)
  • If you stop taking ampicillin too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • Ampicillin is used to treat infections by many Gram-positive and Gram-negative bacteria. (wikipedia.org)
  • Its spectrum of activity is enhanced by co-administration of sulbactam, a drug that inhibits beta lactamase, an enzyme produced by bacteria to inactivate ampicillin and related antibiotics. (wikipedia.org)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ampicillin for Injection, USP and other antibacterial drugs, Ampicillin for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • The addition of an aminoglycoside with ampicillin may increase its effectiveness against Gram-negative bacteria. (nih.gov)
  • Ampicillin is used for treating infections of the middle ear, sinuses, stomach and intestines , bladder, and kidney caused by susceptible bacteria. (medicinenet.com)
  • Ampicillin can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colon (pseudomembranous colitis ). (medicinenet.com)
  • Ampicillin is effective against many bacteria including H. influenzae , N. gonorrhoea , E. coli , Salmonella , and Shigella , streptococci and certain strains of staphylococci. (medicinenet.com)
  • Ampicillin is a penicillin-type antibiotic used for treating bacterial infections middle ear, sinuses, stomach and intestines, bladder, and kidney caused by susceptible bacteria. (medicinenet.com)
  • Ampicillin is a penicillin antibiotic that fights bacteria. (cigna.com)
  • Ampicillin and sulbactam are penicillin antibiotics that fight bacteria. (rexhealth.com)
  • Ampicillin and sulbactam is a combination medicine used to treat many different types of infections caused by bacteria. (rexhealth.com)
  • Oral ampicillin is used to treat infections of the skin, urinary tract, and respiratory tract (sinuses, tonsils, and lung) caused by certain bacteria known to be susceptible to this antibiotic. (wholehealthmd.com)
  • Ampicillin blocks the formation of bacterial cell walls, rendering bacteria unable to multiply and spread. (wholehealthmd.com)
  • And generic only in the United States, ampicillin/sulbactam is used to treat infections caused by bacteria resistant to beta-lactam antibiotics . (bingj.com)
  • Sulbactam blocks the enzyme which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria. (bingj.com)
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  • A semi-synthetic penicillin-type antibiotic, Ampicillin can help fight various infections typically caused by gram positive and gram negative bacteria. (petcarerx.com)
  • Frey Scientific Ampicillin Antibiotic Disc indicates antibiotic effect on bacteria by measuring in-vitro susceptibility of micro-organisms to various antibiotics. (schoolspecialty.com)
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  • Antibiotics such as ampicillin will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • Ampicillin is comparatively less toxic than other antibiotics, and side effects are more likely in those who are sensitive to penicillins and those with a history of asthma or allergies. (wikipedia.org)
  • Ampicillin belongs to a class of antibiotics called penicillins that are used for treating bacterial infections. (medicinenet.com)
  • Amoxicillin and ampicillin are penicillin -type antibiotics used to treat bacterial infections of the middle ear and respiratory tract, and to treat gonorrhea . (medicinenet.com)
  • As with many other antibiotics, under-dosing of ampicillin/sulbactam may lead to resistance. (bingj.com)
  • Ampicillin and sulbactam are both hydrophilic antibiotics and have a volume of distribution (Vd) similar to the volume of extra-cellular body water. (bingj.com)
  • Ampicillin has been used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid. (sigmaaldrich.com)
  • This in ampicillin india may help to explain the body of session enzymes between these monomeric antibiotics. (gastro-service-info.de)
  • Ampicillin should not be used in patients that are hypersensitive to penicillin-type antibiotics and should be used with caution in patients that are hypersensitive to beta-lactam antibiotics. (vcahospitals.com)
  • Ampicillin, derived from penicillin, is one of the most commonly used antibiotics today. (itg.be)
  • Activities extracted from g. despite the effective injection of pediatric number on g party, we could find no published parts in ampicillin cost in india the en- bactericidal sulbactam biopsy of its patients on neurodegenerative glish diseases. (lelycenter.dk)
  • ampicillin (am-pi- sil -in) n. a semisynthetic penicillin administered by mouth or injection in the treatment of a variety of infections, including those of the urinary, respiratory, biliary, and intestinal tracts. (encyclopedia.com)
  • Ampicillin can be administered by mouth, an intramuscular injection (shot) or by intravenous infusion. (wikipedia.org)
  • Ampicillin injection comes as a powder to be mixed with fluid and injected intravenously (into a vein) or intramuscularly (into a muscle). (medlineplus.gov)
  • You may receive ampicillin injection in a hospital or you may administer the medication at home. (medlineplus.gov)
  • If you will be receiving ampicillin injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
  • You should begin to feel better during the first few days of treatment with ampicillin injection. (medlineplus.gov)
  • Use ampicillin injection until you finish the prescription, even if you feel better. (medlineplus.gov)
  • Ampicillin injection is also used in some pregnant women to prevent passing an infection to the baby during birth. (medlineplus.gov)
  • Ampicillin injection is also sometimes used to prevent infection in people who are having certain types of surgery. (medlineplus.gov)
  • or any of the ingredients in ampicillin injection. (medlineplus.gov)
  • If you become pregnant while receiving ampicillin injection, call your doctor. (medlineplus.gov)
  • Ampicillin injection may cause side effects. (medlineplus.gov)
  • Ampicillin for Injection, USP, the monosodium salt of D(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylate is a sterile synthetic penicillin for intramuscular or intravenous use. (nih.gov)
  • Ampicillin for Injection contains approximately 2.9 milliequivalents of sodium per 1 gram of drug. (nih.gov)
  • What is the most important information I should know about ampicillin injection? (cigna.com)
  • What is ampicillin injection? (cigna.com)
  • What should I discuss with my healthcare provider before I receive ampicillin injection? (cigna.com)
  • How is ampicillin injection given? (cigna.com)
  • Your doctor may switch you from ampicillin injection to an oral form of this medicine. (cigna.com)
  • What are the possible side effects of ampicillin injection? (cigna.com)
  • AuroMedics has ampicillin injection available. (ashp.org)
  • Fresenius Kabi has ampicillin injection available. (ashp.org)
  • WG Critical Care has ampicillin injection available. (ashp.org)
  • Ampicillin sodium is given in the hospital by injection into the vein (IV). (vcahospitals.com)
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  • Fresenius Kabi is not currently marketing ampicillin sulbactam injection. (ashp.org)
  • Pfizer has discontinued generic ampicillin sulbactam except for the 1.5 gram and 3 gram ADD-Vantage vials. (ashp.org)
  • What is ampicillin (Omnipen, Principen, Totacillin)? (rxlist.com)
  • What are the possible side effects of ampicillin (Omnipen, Principen, Totacillin)? (rxlist.com)
  • What is the most important information I should know about ampicillin (Omnipen, Principen, Totacillin)? (rxlist.com)
  • What should I discuss with my healthcare provider before taking ampicillin (Omnipen, Principen, Totacillin)? (rxlist.com)
  • How should I take ampicillin (Omnipen, Principen, Totacillin)? (rxlist.com)
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  • Ampicillin (brand names: Omni-Pen®, Teva-ampicillin®, Polyflex, Aminopenicillin®, Principen®, Princillin®, Totacillin®) is an antibacterial medication used to treat certain bacterial infections in small and large animals. (vcahospitals.com)
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  • Other members of this class include ampicillin (Unasyn), piperacillin (Pipracil), and ticarcillin (Ticar). (medicinenet.com)
  • UNASYN is an injectable antibacterial combination consisting of the semisynthetic antibacterial ampicillin sodium and the beta-lactamase inhibitor sulbactam sodium for intravenous and intramuscular administration. (rxlist.com)
  • UNASYN, ampicillin sodium/sulbactam sodium parenteral combination, is available as a white to off-white dry powder for reconstitution. (rxlist.com)
  • UNASYN dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per mL and 125 mg sulbactam per mL. (rxlist.com)
  • 1.5 g of UNASYN (1 g ampicillin as the sodium salt plus 0.5 g sulbactam as the sodium salt) parenteral contains approximately 115 mg (5 mEq) of sodium. (rxlist.com)
  • While UNASYN is indicated only for the conditions listed above, infections caused by ampicillin-susceptible organisms are also amenable to treatment with UNASYN due to its ampicillin content. (rxlist.com)
  • Therefore, mixed infections caused by ampicillin-susceptible organisms and beta-lactamase producing organisms susceptible to UNASYN should not require the addition of another antibacterial. (rxlist.com)
  • Ampicillin is one of the most used drugs in pregnancy, and has been found to be generally harmless both by the Food and Drug Administration in the U.S. (which classified it as category B) and the Therapeutic Goods Administration in Australia (which classified it as category A). It is the drug of choice for treating Listeria monocytogenes in pregnant women, either alone or combined with an aminoglycoside. (wikipedia.org)
  • Which drugs or supplements interact with ampicillin? (medicinenet.com)
  • This reduction affected the urinary excretion of ampicillin and cephalexin substantially because both drugs depend on active renal tubular secretion. (nih.gov)
  • In conclusion, ampicillin/sulbactam may be effective as therapy for meningitis caused by A. baumanii resistant to imipenem and other beta-lactam drugs. (nih.gov)
  • Following a washout period (no drugs) of 7 days, patient will return to clinic for second study visit and receive second set of medication (placebo -vs- Ampicillin). (clinicaltrials.gov)
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  • For IV and IM injections, ampicillin is kept as a powder that must be reconstituted. (wikipedia.org)
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  • PU Tecoflex (Selectophore) Fluka, Ampicillin sodium salt (Powder, Bioreagent, suitable for cell culture), Dulbecco's modified Eagle's medium (DMEM) and fetal bovine serum (FBS) were purchased from Sigma-Aldrich, India. (thefreedictionary.com)
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  • Last two decades enterococci have become as an important cause of nosocomial infections and strains of enterococci have been acquired with resistance to ampicillin ( ampicillin -resistant enterococci [ARE]), high-level aminoglycoside and glycopeptides (vancomycin-resistant enterococci [VRE]) (Billstrom et al. (thefreedictionary.com)
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  • Respiratory infections, including bronchitis, pharyngitis Sinusitis Sepsis Whooping cough, to prevent and treat secondary infections Ampicillin used to also be used to treat gonorrhea, but there are now too many strains resistant to penicillins. (wikipedia.org)
  • At its meeting on April 16, 1975, the Committee on Infectious Diseases reconsidered the problem of ampicillin-resistant strains of Hemophilus influenzae type b. (aappublications.org)
  • 1) Strains of H. influenzae type b highly resistant in vitro to ampicillin have been reported from 20 states and the District of Columbia. (aappublications.org)
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