AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHealth Care
AmphetamineAmphetaminesCentral Nervous System StimulantsDextroamphetamineAmphetamine-Related DisordersMethamphetamineSubstance Abuse DetectionN-Methyl-3,4-methylenedioxyamphetamineDopamineStereotyped Behavior3,4-MethylenedioxyamphetamineNucleus AccumbensDopamine AgentsMotor ActivityBehavior, AnimalGas Chromatography-Mass SpectrometryDopamine Uptake InhibitorsStreet DrugsDesigner DrugsAppetite DepressantsCocaineDopamine Plasma Membrane Transport ProteinsRats, Sprague-DawleyCorpus StriatumHallucinogensEnzyme Multiplied Immunoassay TechniqueForensic MedicineMethylphenidateDose-Response Relationship, Drugp-ChloroamphetamineAdrenergic Uptake InhibitorsDopamine AgonistsMethyltyrosinesNeostriatumMicrodialysisPhenmetrazineDopamine AntagonistsNomifensinePyrazolonesReceptors, Dopamine D2EphedrineFenfluraminePsychoses, Substance-InducedBenzphetamineConditioning, OperantSubstance Withdrawal SyndromeRewardCaudate NucleusHyperkinesisVentral Tegmental AreaSubstance-Related Disordersalpha-MethyltyrosineSerotonin AgentsPhenethylaminesApomorphineDrug InteractionsReceptors, Biogenic AminePhenylpropanolamineSerotoninRacloprideSelf AdministrationAdrenergic AgentsBarbituratesRats, Long-EvansReserpinePargylineChlorfenvinphosHairPsychotropic DrugsFluorescence Polarization ImmunoassayStartle ReactionSpecific GravityLocomotionSelegilineInjections, IntraperitonealReceptors, Dopamine D1Receptors, DopamineSympathomimeticsQuinpiroleTyramineBiogenic MonoaminesExploratory BehaviorNarcolepsyConditioning (Psychology)Conditioning, ClassicalStereoisomerismMonoamine Oxidase InhibitorsPhencyclidineSalicylamidesImmunoassayEuphoriaPhentermineReinforcement ScheduleCatalepsyPutamenNarcoticsCocaine-Related DisordersBiogenic AminesTranylcypromineHaloperidol
Amphetamine
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
Amphetamines
Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.
Central Nervous System Stimulants
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Dextroamphetamine
The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
Amphetamine-Related Disorders
Disorders related or resulting from use of amphetamines.
Methamphetamine
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
Substance Abuse Detection
Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.
N-Methyl-3,4-methylenedioxyamphetamine
An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Stereotyped Behavior
Relatively invariant mode of behavior elicited or determined by a particular situation; may be verbal, postural, or expressive.
3,4-Methylenedioxyamphetamine
An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons and has been used for that purpose experimentally.
Nucleus Accumbens
Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA.
Dopamine Agents
Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
Motor Activity
The physical activity of a human or an animal as a behavioral phenomenon.
Behavior, Animal
The observable response an animal makes to any situation.
Gas Chromatography-Mass Spectrometry
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
Dopamine Uptake Inhibitors
Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.
Street Drugs
Drugs obtained and often manufactured illegally for the subjective effects they are said to produce. They are often distributed in urban areas, but are also available in suburban and rural areas, and tend to be grossly impure and may cause unexpected toxicity.
Designer Drugs
Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.
Appetite Depressants
Agents that are used to suppress appetite.
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Dopamine Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Corpus Striatum
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Hallucinogens
Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations, and other alterations of mood and thinking. Despite the name, the feature that distinguishes these agents from other classes of drugs is their capacity to induce states of altered perception, thought, and feeling that are not experienced otherwise.
Enzyme Multiplied Immunoassay Technique
An immunoenzyme test for the presence of drugs and other substances in urine and blood. The test uses enzyme linked antibodies that react only with the particular drug for which the sample is being tested.
Forensic Medicine
The application of medical knowledge to questions of law.
Methylphenidate
A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
p-Chloroamphetamine
Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.
Adrenergic Uptake Inhibitors
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Dopamine Agonists
Drugs that bind to and activate dopamine receptors.
Methyltyrosines
A group of compounds that are methyl derivatives of the amino acid TYROSINE.
Neostriatum
The phylogenetically newer part of the CORPUS STRIATUM consisting of the CAUDATE NUCLEUS and PUTAMEN. It is often called simply the striatum.
Microdialysis
A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.
Phenmetrazine
A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.
Dopamine Antagonists
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Nomifensine
An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
Pyrazolones
Compounds with a five-membered heterocyclic ring with two nitrogens and a keto OXYGEN. Some are inhibitors of TNF-ALPHA production.
Receptors, Dopamine D2
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.
Ephedrine
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Fenfluramine
A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
Psychoses, Substance-Induced
Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
Benzphetamine
A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
Conditioning, Operant
Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced.
Substance Withdrawal Syndrome
Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
Reward
An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.
Caudate Nucleus
Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.
Hyperkinesis
Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.
Ventral Tegmental Area
A region in the MESENCEPHALON which is dorsomedial to the SUBSTANTIA NIGRA and ventral to the RED NUCLEUS. The mesocortical and mesolimbic dopaminergic systems originate here, including an important projection to the NUCLEUS ACCUMBENS. Overactivity of the cells in this area has been suspected to contribute to the positive symptoms of SCHIZOPHRENIA.
Substance-Related Disorders
Disorders related to substance abuse.
alpha-Methyltyrosine
An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
Serotonin Agents
Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.
Phenethylamines
A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)
Apomorphine
A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.
Drug Interactions
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Receptors, Biogenic Amine
Cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.
Phenylpropanolamine
A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Raclopride
A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.
Self Administration
Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.
Adrenergic Agents
Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.
Barbiturates
A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.
Rats, Long-Evans
An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.
Reserpine
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
Pargyline
A monoamine oxidase inhibitor with antihypertensive properties.
Chlorfenvinphos
An organophosphorus cholinesterase inhibitor that is used as an insecticide and an acaricide.
Hair
A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.
Psychotropic Drugs
A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).
Fluorescence Polarization Immunoassay
Fluoroimmunoassay where detection of the hapten-antibody reaction is based on measurement of the increased polarization of fluorescence-labeled hapten when it is combined with antibody. The assay is very useful for the measurement of small haptenic antigens such as drugs at low concentrations.
Startle Reaction
A complex involuntary response to an unexpected strong stimulus usually auditory in nature.
Specific Gravity
The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.
Locomotion
Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.
Selegiline
A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.
Injections, Intraperitoneal
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
Receptors, Dopamine D1
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D1-class receptor genes lack INTRONS, and the receptors stimulate ADENYLYL CYCLASES.
Receptors, Dopamine
Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.
Sympathomimetics
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Quinpirole
A dopamine D2/D3 receptor agonist.
Tyramine
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
Biogenic Monoamines
Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.
Exploratory Behavior
The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.
Narcolepsy
A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
Conditioning (Psychology)
A general term referring to the learning of some particular response.
Conditioning, Classical
Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Monoamine Oxidase Inhibitors
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
Phencyclidine
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
Salicylamides
Amides of salicylic acid.
Immunoassay
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
Euphoria
An exaggerated feeling of physical and emotional well-being not consonant with apparent stimuli or events; usually of psychologic origin, but also seen in organic brain disease and toxic states.
Phentermine
A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Reinforcement Schedule
A schedule prescribing when the subject is to be reinforced or rewarded in terms of temporal interval in psychological experiments. The schedule may be continuous or intermittent.
Catalepsy
A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.
Putamen
The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS.
Narcotics
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
Cocaine-Related Disorders
Disorders related or resulting from use of cocaine.
Biogenic Amines
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Tranylcypromine
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
Haloperidol
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Analysis of Variance
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Yawning
An involuntary deep INHALATION with the MOUTH open, often accompanied by the act of stretching.
Mescaline
Hallucinogenic alkaloid isolated from the flowering heads (peyote) of Lophophora (formerly Anhalonium) williamsii, a Mexican cactus used in Indian religious rites and as an experimental psychotomimetic. Among its cellular effects are agonist actions at some types of serotonin receptors. It has no accepted therapeutic uses although it is legal for religious use by members of the Native American Church.
3,4-Dihydroxyphenylacetic Acid
A deaminated metabolite of LEVODOPA.
Prenylamine
A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)
Lisuride
An ergot derivative that acts as an agonist at dopamine D2 receptors (DOPAMINE AGONISTS). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (SEROTONIN RECEPTOR AGONISTS).
Norepinephrine Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. It regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.
Catha
A plant genus of the family CELASTRACEAE. The leafy stems of khat are chewed by some individuals for stimulating effect. Members contain ((+)-norpseudoephedrine), cathionine, cathedulin, cathinine & cathidine.
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

Extra-vesicular binding of noradrenaline and guanethidine in the adrenergic neurones of the rat heart: a proposed site of action of adrenergic neurone blocking agents. (1/1182)

1 The binding and efflux characteristics of [14C]-guanethidine and [3H]-noradrenaline were studied in heart slices from rats which were pretreated with reserpine and nialamide. 2 Binding of both compounds occurred at extra-vesicular sites within the adrenergic neurone. After a brief period of rapid washout, the efflux of [14C]-guanethidine and [3H]-noradrenaline proceeded at a steady rate. The efflux of both compounds appeared to occur from a single intraneuronal compartment. 3 (+)-Amphetamine accelerated the efflux of [14C]-noradrenaline; this effect was inhibited by desipramine. 4 Unlabelled guanethidine and amantadine also increased the efflux of labelled compounds. Cocaine in high concentrations increased slightly the efflux of [14C]-guanethidine but not that of [3H]-noradrenaline. 5 Heart slices labelled with [3H]-noradrenaline became refractory to successive exposures to releasing agents although an appreciable amount of labelled compound was still present in in these slices. 6 It is suggested that [14C]-guanethidine and [3H]-noradrenaline are bound at a common extravesicular site within the adrenergic neurone. Binding of guanethidine to the extra-vesicular site may be relevant to its pharmacological action, i.e., the blockade of adrenergic transmission.  (+info)

Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine. (2/1182)

Caffeine and nicotine are the main psychoactive ingredients of coffee and tobacco, with a high frequency of concurrent use in humans. This study examined the effects of chronic caffeine exposure on 1) rates of acquisition of a nicotine discrimination (0.1 or 0.4 mg/kg, s.c., training doses) and 2) the pharmacological characteristics of the established nicotine discrimination in male Sprague-Dawley rats. Once rats learned to lever-press reliably under a fixed ratio of 10 schedule for food pellets, they were randomly divided into two groups; 12 animals were maintained continuously on caffeine added to the drinking water (3 mg/ml) and another 12 control rats continued to drink tap water. In each group of water- and caffeine-drinking rats, there were six rats trained to discriminate 0.1 mg/kg of nicotine from saline and six rats trained to discriminate 0.4 mg/kg of nicotine from saline. Regardless of the training dose of nicotine, both water- and caffeine-drinking groups required a comparable number of training sessions to attain reliable stimulus control, although there was a trend for a slower acquisition in the caffeine-drinking group trained with 0.1 mg/kg of nicotine. Tests for generalization to different doses of nicotine revealed no significant differences in potency of nicotine between water- and caffeine-drinking groups. The nicotinic-receptor antagonist mecamylamine blocked the discriminative effects of 0.1 and 0.4 mg/kg nicotine with comparable potency and efficacy in water- and caffeine-drinking groups. There was a dose-related generalization to both the 0.1 and 0.4 mg/kg nicotine cue (maximum average of 51-83%) in water-drinking rats after i.p. treatment with d-amphetamine, cocaine, the selective dopamine uptake inhibitor GBR-12909, apomorphine, and the selective dopamine D1 receptor agonist SKF-82958, but not in caffeine-drinking rats (0-22%). There was no generalization to the nicotine cues after i.p. treatment with caffeine or the selective D2 (NPA) and D3 (PD 128,907) dopamine-receptor agonists in water- and caffeine-drinking rats. The dopamine-release inhibitor CGS 10746B reduced the discriminative effects of 0.4 mg/kg nicotine in water-drinking rats, but not in caffeine-drinking rats. There was no evidence of development of tolerance or sensitization to nicotine's effects throughout the study. In conclusion, chronic caffeine exposure (average, 135 mg/kg/day) did not affect the rate of acquisition of the nicotine discrimination, but it did reduce the dopaminergic component of the nicotine-discriminative cue. The reduction of the dopaminergic component of the nicotine cue was permanent, as this effect was still evident after the caffeine solution was replaced with water in caffeine-drinking rats. That nicotine could reliably serve as a discriminative stimulus in the absence of the dopaminergic component of its discriminative cue may differentiate nicotine from "classical dopaminergic" drugs of abuse such as cocaine and amphetamine.  (+info)

N-oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication. (3/1182)

(+)- And (-)-amphetamine and methamphetamine were N-oxygenated by the cDNA expressed adult human flavin-containing monooxygenase form 3 (FMO3), their corresponding hydroxylamines. Two major polymorphic forms of human FMO3 were studied, and the results suggested preferential N-oxygenation by only one of the two enzymes. Chemically synthesized (+/-)-amphetamine hydroxylamine was also a substrate for the human FMO3 and it was converted to phenylpropanone oxime with a stereoselectivity ratio of trans/cis of 5:1. Human FMO3 also N-oxygenated methamphetamine to produce methamphetamine hydroxylamine. Methamphetamine hydroxylamine was also N-oxygenated by human FMO3, and the ultimate product observed was phenylpropanone. For amphetamine hydroxylamine, studies of the biochemical mechanism of product formation were consistent with the production of an N, N-dioxygenated intermediate that lead to phenylpropanone oxime. This was supported by the observation that alpha-deutero (+/-)-amphetamine hydroxylamine gave an inverse kinetic isotope effect on product formation in the presence of human FMO3. For methamphetamine, the data were consistent with a mechanism of human FMO3-mediated N,N-dioxygenation but the immediate product, a nitrone, rapidly hydrolyzed to phenylpropanone. The pharmacological activity of amphetamine hydroxylamine, phenylpropanone oxime, and methamphetamine hydroxylamine were examined for effects at the human dopamine, serotonin, and norepinephrine transporters. Amphetamine hydroxylamine and methamphetamine hydroxylamine were apparent substrates for the human biogenic amine transporters but phenylpropanone oxime was not. Presumably, phenylpropanone oxime or nitrone formation from amphetamine and methamphetamine, respectively, represents a detoxication process. Because of the potential toxic nature of amphetamine hydroxylamine and methamphetamine hydroxylamine metabolites and the polymorphic nature of N-oxygenation, human FMO3-mediated metabolism of amphetamine or methamphetamine may have clinical consequences.  (+info)

The Ca2+ channel blockade changes the behavioral and biochemical effects of immobilization stress. (4/1182)

We investigated how the effects of chronic immobilization stress in rats are modified by Ca2+ channel blockade preceding restraint sessions. The application of nifedipine (5 mg/kg) shortly before each of seven daily 2 h restraint sessions prevented the development of sensitized response to amphetamine as well as the stress-induced elevation of the densities of L-type Ca2+ channel in the hippocampus and significantly reduced the elevation of the densities of [3H]nitrendipine binding sites in the cortex and D1 dopamine receptors in the limbic forebrain. Neither stress, nor nifedipine affected the density of alpha 1-adrenoceptors and D1 receptors in the cerebral cortex nor D2 dopamine receptors in the striatum. A single restraint session caused an elevation of blood corticosterone level that remained unaffected by nifedipine pretreatment, but the reduction of this response during the eighth session was significantly less expressed in nifedipine-treated rats. We conclude that L-type calcium channel blockade prevents development of several stress-induced adaptive responses.  (+info)

Necessary role for ventral tegmental area adenylate cyclase and protein kinase A in induction of behavioral sensitization to intraventral tegmental area amphetamine. (5/1182)

In the present study, we investigated the effects of selective activation or inhibition of ventral tegmental area (VTA) adenylate cyclase (AC) and protein kinase A (PKA) on long-term sensitization induced by repeated intra-VTA or peripheral amphetamine (AMPH). Selective inhibition of AC by SQ 22,536 (9-(tetrahydro-2-furanyl)-9H-purin-6-amine; 100 nmol/side bilateral into VTA) had no effect on acute basal locomotion but attenuated the locomotor stimulation induced by acute i.p. AMPH (1.5 mg/kg). Coinjection of SQ 22,536 (100 nmol/side) fully blocked the sensitization induced by repeated intra-VTA AMPH (15 nmol/side) but had no detectable effect on the sensitization induced by repeated i. p. AMPH. Persistent activation of AC by intra-VTA cholera toxin (500 ng/side) modestly increased acute locomotion and induced a robust sensitization to i.p. AMPH challenge 10 days after the last of three repeated VTA microinjections. Selective inhibition of PKA by Rp-adenosine-3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS; 25 nmol/side) had no effect on acute basal or AMPH-stimulated locomotion. Coinjection of Rp-cAMPS (25 nmol/side) fully blocked the sensitization induced by repeated intra-VTA AMPH but had no effect on sensitization induced by repeated i.p. AMPH. Intra-VTA microinjection of the selective PKA activator Sp-adenosine-3',5'-cyclic monophosphothioate triethylamine (Sp-cAMPS; 25-100 nmol/side) dose-dependently stimulated acute locomotion and exerted synergistic effects on locomotor activity when coinfused into the VTA with AMPH but had no detectable effect on acute i.p. AMPH-induced locomotion. Repeated intra-VTA Sp-cAMPS did not induce sensitization to AMPH challenge but potentiated the sensitization induced by repeated i.p. AMPH. These results suggest that VTA cAMP signal transduction is necessary for the induction of persistent sensitization to intra-VTA amphetamine and that peripheral and intra-VTA AMPH may not induce behavioral sensitization by identical mechanisms.  (+info)

Modulation of amphetamine-stimulated [3H]dopamine release from rat pheochromocytoma (PC12) cells by sigma type 2 receptors. (6/1182)

An important regulatory mechanism of synaptic dopamine (DA) levels is activation of the dopamine transporter (DAT), which is a target for many drugs of abuse, including amphetamine (AMPH). sigma receptors are located in dopaminergic brain areas critical to reinforcement. We found previously that agonists at sigma2 receptors enhanced the AMPH-stimulated release of [3H]DA from slices of rat caudate-putamen. In the present study, we modeled this response in undifferentiated pheochromocytoma-12 (PC12) cells, which contain both the DAT and sigma2 receptors but not neural networks that can complicate investigation of individual neuronal mechanisms. We found that enhancement of AMPH-stimulated [3H]DA release by the sigma agonist (+)-pentazocine was blocked by sigma2 receptor antagonists. Additionally, the reduction in the effect of (+)-pentazocine by the inclusion of ethylene glycol bis(beta-aminoethyl ether)-N,N,N', N'-tetraacetic acid led us to hypothesize that sigma2 receptor activation initiated a Ca2+-dependent process that resulted in enhancing the outward flow of DA via the DAT. The source of Ca2+ required for the enhancement of reverse transport did not appear to be via N- or L-type voltage-dependent Ca2+ channels, because it was not affected by nitrendipine or omega-conotoxin. However, two inhibitors of Ca2+/calmodulin-dependent protein kinase II blocked enhancement in AMPH-stimulated release by (+)-pentazocine. Our findings suggest that sigma2 receptors are coupled to the DAT via a Ca2+/calmodulin-dependent protein kinase II transduction system in PC12 cells, and that sigma2 receptor antagonists might be useful in the treatment of drug abuse by blocking elevation of DA levels via reversal of the DAT.  (+info)

Effects of atypical antipsychotic drug treatment on amphetamine-induced striatal dopamine release in patients with psychotic disorders. (7/1182)

Clozapine, risperidone, and other new "atypical" antipsychotic agents are distinguished from traditional neuroleptic drugs by having clinical efficacy with either no or low levels of extrapyramidal symptoms (EPS). Preclinical models have focused on striatal dopamine systems to account for their atypical profile. In this study, we examined the effects of clozapine and risperidone on amphetamine-induced striatal dopamine release in patients with psychotic disorders. A novel 11C-raclopride/PET paradigm was used to derive estimates of amphetamine-induced changes in striatal synaptic dopamine concentrations and patients were scanned while antipsychotic drug-free and during chronic treatment with either clozapine or risperidone. We found that amphetamine produced significant reductions in striatal 11C-raclopride binding during the drug-free and antipsychotic drug treatment phases of the study which reflects enhanced dopamine release in both conditions. There were no significant differences in % 11C-raclopride changes between the two conditions indicating that these atypical agents do not effect amphetamine-related striatal dopamine release. The implications for these data for antipsychotic drug action are discussed.  (+info)

Review article: mechanisms and management of hepatotoxicity in ecstasy (MDMA) and amphetamine intoxications. (8/1182)

The social use of ecstasy (methylenedioxymethampheta-mine, MDMA) and amphetamines is widespread in the UK and Europe, and they are popularly considered as 'safe'. However, deaths have occurred and hepatotoxicity has featured in many cases of intoxication with amphetamine or its methylenedioxy analogues such as ecstasy. Recreational use of these drugs presents an important but often concealed cause of hepatitis or acute liver failure, particularly in young people. The patterns of liver damage and multiple putative mechanisms of injury are discussed. Recognition of the aetiological agent requires a high index of suspicion. Optimum management of the resultant liver damage, including the controversial role of liver transplantation for fulminant hepatic failure, is also discussed.  (+info)

Repeated amphetamine administration alters the expression of mRNA for AMPA receptor subunits in rat nucleus accumbens and...Repeated amphetamine administration alters the expression of mRNA for AMPA receptor subunits in rat nucleus accumbens and...
TY - JOUR. T1 - Repeated amphetamine administration alters the expression of mRNA for AMPA receptor subunits in rat nucleus accumbens and prefrontal cortex. AU - Lu, Wenxiao. AU - Chen, Huiyuan. AU - Xue, Chang Jiang. AU - Wolf, Marina E.. PY - 1997/7. Y1 - 1997/7. N2 - Recent evidence suggests that behavioral sensitization to amphetamine is associated with alterations in excitatory amino acid (EAA) transmission in perikarya (ventral tegmental area) and terminal regions (nucleus accumbens [NAc]) of the mesoaccumbens dopamine system. The present study determined whether repeated amphetamine administration alters expression of mRNAs for AMPA receptor subunits. We studied the NAc, because it is the site of expression of amphetamine sensitization, and the prefrontal cortex (PFC), because it is the origin of EAA projections that regulate the mesoaccumbens dopamine system. Rats were treated for 5 days with 5 mg/kg/day amphetamine sulfate or vehicle (controls) and perfused 3 or 14 days after the last ...
https://ohsu.pure.elsevier.com/en/publications/repeated-amphetamine-administration-alters-the-expression-of-mrna
Individual differences in amphetamine sensitization, behavior and central monoamines<...
TY - JOUR. T1 - Individual differences in amphetamine sensitization, behavior and central monoamines. AU - Scholl, Jamie L.. AU - Feng, Na. AU - Watt, Michael J.. AU - Renner, Kenneth J.. AU - Forster, Gina L.. PY - 2009/3/2. Y1 - 2009/3/2. N2 - Repeated amphetamine treatment results in behavioral sensitization in a high percentage of rats. Alterations to plasma corticosterone, neural monoamines and stress behavior can accompany amphetamine sensitization. Whether these changes occur following repeated amphetamine treatment in the absence of behavioral sensitization is not known. Male Sprague-Dawley rats were treated with amphetamine (2.5 mg/kg, i.p.) or saline once daily for 6 days. Amphetamine-induced locomotion and stereotypy, open-field anxiety behavior, plasma corticosterone and limbic monoamines were measured during withdrawal. Sixty-two percent of amphetamine-treated rats showed behavioral sensitization over the test periods. Only amphetamine-sensitized rats showed increased latency to ...
https://nebraska.pure.elsevier.com/en/publications/individual-differences-in-amphetamine-sensitization-behavior-and-
Differential development of autoreceptor subsensitivity and enhanced dopamine release during amphetamine sensitization<...Differential development of autoreceptor subsensitivity and enhanced dopamine release during amphetamine sensitization<...
TY - JOUR. T1 - Differential development of autoreceptor subsensitivity and enhanced dopamine release during amphetamine sensitization. AU - Wolf, Marina. AU - White, F. J.. AU - Nassar, R.. AU - Brooderson, R. J.. AU - Khansa, M. R.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - Various changes in the function of dopamine neurons have been proposed to underly the development of behavioral sensitization to the locomotor stimulant effects of d-amphetamine. The present study examined the relative importance of two such mechanisms after both short (3-4 days off) and longer (10-14 days off) withdrawals from repeated amphetamine or saline injection (1 mg/kg/day, days 1-5 and 8-12). First, single-unit recording was used to examine the sensitivity of impulse-regulating somatodendritic autoreceptors located on mesoaccumbens dopamine neurons in the rat ventral tegmental area. Second, in vivo microdialysis was used to examine the ability of amphetamine challenge to increase extracellular dopamine levels in the rat ...
https://ohsu.pure.elsevier.com/en/publications/differential-development-of-autoreceptor-subsensitivity-and-enhan
Increased demand for amphetamine treatment in rural Australia | Addiction Science & Clinical Practice | Full TextIncreased demand for amphetamine treatment in rural Australia | Addiction Science & Clinical Practice | Full Text
A substantial increase in substance treatment episodes for methamphetamine problems suggests characteristics of the treatment population could have changed and that targeted treatment programs are required. To determine who methamphetamine treatment should be designed for this study has two aims. First, to empirically describe changes in amphetamine treatment presentations to a rural NSW drug and alcohol treatment agency over time. Second, to examine how these characteristics may affect the likelihood of being treated for amphetamines compared to other drugs. The Australian Alcohol and Other Drug Treatment Services National Minimum Data Set (AODTS-NMDS) containing closed treatment episodes from a single agency from three time periods was used. Characteristics of people receiving amphetamine treatments in these three periods were compared and the effects of these characteristics on the odds of being treated for amphetamine were estimated using a logistic regression model. The characteristics utilised in
https://ascpjournal.biomedcentral.com/articles/10.1186/s13722-019-0144-6
Amphetamines Effects | Articles on AmphetaminesAmphetamines Effects | Articles on Amphetamines
The effects of amphetamines described. See what amphetamine use, amphetamines abuse and amphetamines addiction does to amphetamine users and amphetamine addicts.
https://www.thegooddrugsguide.com/amphetamines/effects.htm
How To Buy Amphetamine Online , republicconstructioncorp.comHow To Buy Amphetamine Online , republicconstructioncorp.com
Please read the label you buy from the label so you know the dosage and what kinds of Amphetamine you need. Drugs made by mixing Amphetamine with other types of illegal medicines, such as tobacco or tobacco products. It is important for us to understand drug-related disorders so we can be on the safe side or being careful that you dont become ill because amphetamine gives you painkillers. Amphetamine are also known as anorexic drugs. They may cause an overdose of many substances, which increases the risk for serious problems. Amphetamine is sometimes found in certain medicines (e.g. alcohol, tea, heroin and alcohol). Amphetamine may be found in chewing gum, chewing alcohols, gum for chewing, e.g. Nicotine in e.g. prescription prescription nicotine, is not as effective, sometimes, as in amphetamine, which can cause a high blood nicotine level such as about 0.5 mg/100 ml. Amphetamine can also be taken as an anti-depressant drug. An occasional withdrawal from any of the four types of Amphetamine will
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Amphetamine Detox Centers - Amphetamine Withdrawal TreatmentAmphetamine Detox Centers - Amphetamine Withdrawal Treatment
Amphetamine detox is only the first step in addiction treatment.Amphetamine detox is only the first step in addiction treatment. Without regular, long-term treatment in conjunction with amphetamine detox, many users will return to abusing the drug. Treatment may be provided on an inpatient or outpatient basis. Each person is different, and having a treatment plan tailored to each persons specific situation increases the chances of a good outcome. Support groups such as Narcotics Anonymous can be helpful to some people going through an addiction. Supportive family and friends increase the chances of a successful recovery. Addiction is a chronic disease that needs long-term treatment.. According to the TEDS report, amphetamine treatment admission rates increased between 1993 and 1999 by 250 percent or more in 14 states and by 100 to 249 percent in another 10 states. There are many treatment options available that can be tailored to your specific situation. Amphetamine addiction treatment is not ...
https://www.projectknow.com/detox-withdrawal/amphetamine/
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Amphetamine has complex behavioral actions in the rat that depend upon the release of dopamine in striatal and mesolimbic brain regions. To explore a possible role of the dopamine-sensitive cAMP second-messenger system in mediating these effects, we examined the effects of in vivo amphetamine treatments on the D1 receptor-coupled adenylate cyclase system in membranes from striatal and mesolimbic rat brain regions. The results show that amphetamine produces a regional, dose- and time- dependent down-regulation of adenylate cyclase activity. Intermediate and high doses of amphetamine (2.5 and 7.5 mg/kg, respectively), but not a low dose (1.0 mg/kg), resulted in a decrease in the apparent Vmax and/or an increase in the apparent Ka for the selective D1 partial agonist, SKF38393, in striatal membranes 30 min after amphetamine treatment. Treatment of rats with 7.5 mg/kg amphetamine for 30 and 60 min, but not 10 min, similarly resulted in a down-regulation of D1- mediated adenylate cyclase activity in ...
http://www.jneurosci.org/content/6/8/2245
Amphetamines - Step One Recovery
Amphetamines are stimulants that speed up the bodys system. Many are legally prescribed and used to treat attention-deficit hyperactivity disorder (ADHD). Street names include Bennies, Black Beauties, Crank, Ice, Speed and Uppers. Amphetamines can look like pills or powder. Common prescription amphetamines include methylphenidate (Ritalin® or Ritalin SR®), amphetamine and dextroamphetamine (Adderall®) and dextroamphetamine (Dexedrine®).. Amphetamines are generally taken orally or injected. However, the addition of ice, the slang name of crystallized methamphetamine hydrochloride, has promoted smoking as another mode of administration. Just as crack is smokable cocaine, ice is smokable methamphetamine. The effects of amphetamines and methamphetamine are similar to cocaine, but their onset is slower and their duration is longer. In contrast to cocaine, which is quickly removed from the brain and is almost completely metabolized, methamphetamine remains in the central nervous system ...
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The psychogenetically selected Roman rat lines differ in the susceptibility to develop amphetamine sensitization<...The psychogenetically selected Roman rat lines differ in the susceptibility to develop amphetamine sensitization<...
TY - JOUR. T1 - The psychogenetically selected Roman rat lines differ in the susceptibility to develop amphetamine sensitization. AU - Corda, Maria G.. AU - Piras, Giovanna. AU - Lecca, Daniele. AU - Fernández-Teruel, Alberto. AU - Driscoll, Peter. AU - Giorgi, Osvaldo. PY - 2005/2/10. Y1 - 2005/2/10. N2 - The mesolimbic dopamine system is considered to play a pivotal role in the locomotor activation produced by psychostimulants and in the augmentation of this effect observed upon repeated drug administration, a process denominated behavioral sensitization. The selective breeding of Roman high- (RHA) and low-avoidance (RLA) rats, respectively, for rapid versus poor active avoidance acquisition has resulted in two phenotypes that differ in the functional properties of the mesolimbic dopamine system and in their behavioral and neurochemical responses to addictive drugs, including psychostimulants and opiates. Hence, the present study was designed to compare the ability of these lines to develop ...
https://portalrecerca.uab.cat/en/publications/the-psychogenetically-selected-roman-rat-lines-differ-in-the-susc
Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat...Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat...
BACKGROUND: Acute depletion of tyrosine using a tyrosine-free amino acid mixture offers a novel dietary approach to inhibit activated dopamine pathways in the brain. This study investigated the potential of in vivo functional magnetic resonance imaging (fMRI) methods as a noninvasive means to detect effects of tyrosine depletion on dopamine function. METHODS: Changes in blood-oxgenation level dependent (BOLD) contrast induced by administration of the dopamine-releasing agent, amphetamine (3 mg/kg i.v.), were measured in halothane-anaesthetised rats. RESULTS: Amphetamine evoked changes in BOLD signal intensity with the greatest effects observed in the nucleus accumbens (-7.7%), prefrontal cortex (-13.6%), and motor cortex (+12.5%). Pretreatment with a tyrosine-free amino acid mixture attenuated the response to amphetamine in some regions (nucleus accumbens and prefrontal cortex), but not others (motor cortex). Amphetamine itself had no effect in thalamus and hippocampus but, surprisingly, increased the
https://pharm.ox.ac.uk/publications/131135
Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat...Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat...
BACKGROUND: Acute depletion of tyrosine using a tyrosine-free amino acid mixture offers a novel dietary approach to inhibit activated dopamine pathways in the brain. This study investigated the potential of in vivo functional magnetic resonance imaging (fMRI) methods as a noninvasive means to detect effects of tyrosine depletion on dopamine function. METHODS: Changes in blood-oxgenation level dependent (BOLD) contrast induced by administration of the dopamine-releasing agent, amphetamine (3 mg/kg i.v.), were measured in halothane-anaesthetised rats. RESULTS: Amphetamine evoked changes in BOLD signal intensity with the greatest effects observed in the nucleus accumbens (-7.7%), prefrontal cortex (-13.6%), and motor cortex (+12.5%). Pretreatment with a tyrosine-free amino acid mixture attenuated the response to amphetamine in some regions (nucleus accumbens and prefrontal cortex), but not others (motor cortex). Amphetamine itself had no effect in thalamus and hippocampus but, surprisingly, increased the
https://www.pharm.ox.ac.uk/publications/131135
Effect of amphetamine on cerebral blood flow and capillary perfusion<...Effect of amphetamine on cerebral blood flow and capillary perfusion<...
TY - JOUR. T1 - Effect of amphetamine on cerebral blood flow and capillary perfusion. AU - Russo, Karen E.. AU - Hall, Wyatt. AU - Chi, Oak Z.. AU - Sinha, Arabinda K.. AU - Weiss, Harvey R.. PY - 1991/2/22. Y1 - 1991/2/22. N2 - The purpose of this study was to determine the cerebral regional microvascular and vascular responses to amphetamine sulfate at a dose (5 mg/kg) known to affect neuronal function. Cerebral blood flow (14C-iodoantipyrine method) and percent of perfused capillaries (fluorescein isothiocyanate-dextran and alkaline phosphatase staining method) were determined during control and after intravenous administration of amphetamine in conscious Long-Evans rats. Amphetamine caused an increase in blood pressure (34%) and heart rate (31%). There was a significant increase in averaged cerebral blood flow from 98 ±8to 166±9 ml/min/100 g after amphetamine. This flow increase was significant in the cortex, basal ganglia, pons and medulla, however the increase was not significant in the ...
https://www.researchwithrutgers.com/en/publications/effect-of-amphetamine-on-cerebral-blood-flow-and-capillary-perfus
Variables Related to Amphetamine Use.
A sample of 985 self-admitted amphetamine users was compared with a sample of airmen who had no known record of drug abuse. Results of this study indicate that there is a very strong likelihood for amphetamine users to abuse other drugs. There are relationships between amphetamine use and geographic area of enlistment, religious preference, aptitude scores, educational level, and age at enlistment. Amphetamine use is also related to the likelihood of getting an undesirable discharge and to lower APR ratings. (Author)*Amphetamines
http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=AD0783236
A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized RatsA New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats
Background: Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy. Objective: We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal. Method: The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. ...
https://ibiss-r.rcub.bg.ac.rs/handle/123456789/3765
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amphetamine - Symptoms, Treatments and Resources for amphetamineamphetamine - Symptoms, Treatments and Resources for amphetamine
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amphetamine - Symptoms, Treatments and Resources for amphetamineamphetamine - Symptoms, Treatments and Resources for amphetamine
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Eve 6 amphetamines skype
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Amphetamine stereotypy: the influence of environmental factors and prepotent behavioral patterns on its topography and...Amphetamine stereotypy: the influence of environmental factors and prepotent behavioral patterns on its topography and...
This report describes a series of experiments, all of which demonstrate a strong contribution of the behavioral pattern manifested at the time of initial amphetamine injection to the topography and development of the stereotypy that develops with chronic amphetamine intoxication. These initial behavioral patterns reflect (i) learned behaviors, (ii) species-specific behaviors, (iii) behaviors associated with amphetamine arousal, and (iv) novel behaviors reflecting unique environmental circumstances prevailing at the time of administration. In an experiment using eight dogs administered amphetamine in a situation which allowed interaction between the animals, the behavioral stereotypies that developed were comprised of the social interaction patterns ongoing at the time of initial drug effects. Experiments with rats have demonstrated that the configuration of the enclosure in which they are injected influences the initial behavioral reactions to amphetamine and thus modifies the stereotypy. In experiments
https://www.semanticscholar.org/paper/Amphetamine-stereotypy-the-influence-of-environmen-Ellinwood-Kilbey/938887fa873e0bed6931c7bcab00a2270224f2f2
The Use of Amphetamines for Improving Cognitive Impairment in Patients by Hayley KumThe Use of Amphetamines for Improving Cognitive Impairment in Patients by Hayley Kum
Background: Multiple sclerosis (MS) is an autoimmune disorder that results in debilitating cognitive impairment in 40-65% of patients. There are no current treatments for this symptom of MS. This is a systematic review of literature on the impact amphetamines have on cognitive function of MS patients. Methods: An exhaustive search of available medical literature was conducted using MEDLINE-Ovid, MEDLINE-PubMed, Web of Science, and CINAHL. Keywords used included: amphetamines and multiple sclerosis. Relevant articles were assessed for quality using GRADE. Results: Three studies have statistically significant improvements in some aspects of cognitive function in patients on amphetamines when compared to placebo. However, a high rate of adverse events were noted with L-isomer or D-isomer amphetamines alone. Conclusion: Amphetamines positively impact cognitive function in MS patients. Mixed amphetamine salts extended release (MAS-XR) seemingly have the lowest rate of adverse effects with the greatest
http://commons.pacificu.edu/pa/586/
Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats. | PassportNornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats. | Passport
Rats were trained in a two-lever food-reinforced operant task to discriminate (+)-amphetamine (1 mg/kg) from saline. After discrimination training stabilized, test doses of (+)-amphetamine (0.0625-2.0 mg/kg), (-)-nicotine (0.1-1.0 mg/kg), or (-)-nornicotine (1-10 mg/kg) were assessed for their ability to substitute for the (+)-amphetamine training dose during brief test sessions in which food reinforcement was withheld. As expected, as the test dose of (+)-amphetamine increased, there was a dose-related increase in drug-appropriate responding, with both 1 and 2 mg/kg test doses substituting fully for the (+)-amphetamine training dose. Both (-)-nicotine and (-)-nornicotine showed partial substitution (approximately 50% drug-appropriate responding) for the (+)-amphetamine training dose, with (-)-nicotine being more potent than (-)-nornicotine. Rate suppressant effects prevented the assessment of higher doses of (-)-nicotine or (-)-nornicotine. Thus, while (-)-nicotine and (-)-nornicotine share ...
https://passport.as.uky.edu/nornicotine-partially-substitutes-amphetamine-drug-discrimination-paradigm-rats
Amphetamine for Weight LossAmphetamine for Weight Loss
Long term consumption of Amphetamine and its derivatives increases the speed of weight loss by reducing appetite. However, the consumption is an extremely high risk that may lead to death. Users are advised to take extra precautions with slimming products available in the market. There are slimming products detected containing drugs in order to obtain visible weight loss. Counterfeit slimming products may produce effects as mention above especially heart attack/stroke.. Amphetamine Abuse. There are lots of reason to promote the abuse of Amphetamine. Some people take Amphetamine to improve performance in sport or work and to boost confidence. However, it is always abuse to be high and excited. Based on report by Agensi Anti Dadah Kebangsaan (AADK), the number of Amphetamine and its derivatives addiction is the highest after heroin, morphine and ganja. Each year shows an increase in the number of seizures of the Amphetamine pills and its derivatives. In year 2012, 11,321,142 pills and its ...
http://www.myhealth.gov.my/en/amphetamine-for-weight-loss/
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Mental Health Update: Amphetamines and Parkinsons diseaseMental Health Update: Amphetamines and Parkinsons disease
People who use amphetamines could be at an increased risk of developing Parkinsons disease. Apart from their illegal use amphetamines such as Benzedrine and Dexedrine are often prescribed for people with attention-deficit hyperactivity disorder (ADHD) and narcolepsy, as weight-loss pills and are also used to treat traumatic brain injury. Researchers from the U.S. health organisation Kaiser Permanente studied 66,348 people who were initially studied between 1964 and 1973 and re-evaluated in 1995. 1,154 people had been diagnosed with Parkinsons by the end of the study. The participants were asked about their use of amphetamines - either as weight-loss pills or in the form of Benzedrine or Dexedrine. There was no increase in risk for the people who used amphetamines for weight loss but those who took Benzadrine or Dexedrine were nearly 60% more likely to develop Parkinsons. Amphetamines are known to affect the release and uptake of dopamine, the most important neurotransmitter involved in ...
http://mentalhealthupdate.blogspot.com/2011/02/amphetamines-and-parkinsons-disease.html
PRIME PubMed | Blockade of D1 dopamine receptors in the medial prefrontal cortex attenuates amphetamine- and methamphetamine...PRIME PubMed | Blockade of D1 dopamine receptors in the medial prefrontal cortex attenuates amphetamine- and methamphetamine...
PubMed journal article: Blockade of D1 dopamine receptors in the medial prefrontal cortex attenuates amphetamine- and methamphetamine-induced locomotor activity in the rat. Download Prime PubMed App to iPhone, iPad, or Android
https://www.unboundmedicine.com/medline/citation/19733155/Blockade_of_D1_dopamine_receptors_in_the_medial_prefrontal_cortex_attenuates_amphetamine__and_methamphetamine_induced_locomotor_activity_in_the_rat_
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Chronic amphetamine enhances visual input to and suppresses visual output from the superior colliculus in withdrawal - White...Chronic amphetamine enhances visual input to and suppresses visual output from the superior colliculus in withdrawal - White...
Heightened distractibility is a core symptom of Attention Deficit Hyperactivity Disorder (ADHD). Effective treatment is normally with chronic orally administered psychostimulants including amphetamine. Treatment prevents worsening of symptoms but the site of therapeutic processes, and their nature, is unknown. Mounting evidence suggests that the superior colliculus (SC) is a key substrate in distractibility and a therapeutic target, so we assessed whether therapeutically-relevant changes are induced in this structure by chronic oral amphetamine. We hypothesized that amphetamine would alter visual responses and morphological measures. Six-week old healthy male rats were treated with oral amphetamine (2, 5 or 10 mg/kg) or a vehicle for one month after which local field potential and multiunit recordings were made from the superficial layers of the SC in response to whole-field light flashes in withdrawal. Rapid Golgi staining was also used to assess dendritic spines, and synaptophysin staining was ...
http://eprints.whiterose.ac.uk/131624/
The Various Types of Amphetamines and Their Effects - DHS Dental Office
While you might imagine amphetamine addiction to be one of the issues you would see on television instead of affecting someone you are about in real life, it is an all too common problem among people of all ages. Amphetamines can be legitimately prescribed to people for certain issues like ADHD (Attention Deficit Hyperactivity Disorder), but it can be also be abused. What Are Some Commonly Abused Amphetamines? There are several common amphetamine drugs that are quote commonly illicitly used. Adderall is a prescription amphetamine often used to treat patients with attention deficit or hyperactivity disorders. It can be prescribed in several different strengths, which makes the higher strength of 30mg pills much more valuable to people who abuse it often. Methamphetamine is a drug that is often prescribed under the name Desoxyn, but it is also one that is commonly created by folks who might gather up a lot of chemicals necessary to make it themselves, which can lead to dangerous and addictive ...
http://www.dhsorg.org/the-various-types-of-amphetamines-and-their-effects/
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Amphetamine in postmortem liver sample?Amphetamine in postmortem liver sample?
Amphetamine is a psychostimulant drug, known to produce increased wakefulness and focus in association with decreased fatigue and appetite. Clinical uses of amphetamine include chronic administration for the treatment of narcolepsy in adults and attention-deficit/hyperactivity disorder in children [1]. It is also used as a drug of abuse [2]. Amphetamines are well absorbed from the gastrointestinal tract and metabolized by deamination, oxidation and hydroxylation. Approximately 90% of the dose is excreted in the urine within 3-4 days [1]. An amphetamine overdose is rarely fatal but can lead to a number of different symptoms, including psychosis, chest pain and hypertension. Cardiovascular effects include increased heart rate and blood pressure, chest pain, myocardial ischemia or infarction, dysrhythmias, cardiovascular collapse and death [2].. A typical postmortem toxicological analysis is identification of the drugs or chemicals presence in postmortem specimens [3]. Blood, urine, bile, liver and ...
https://www.peertechz.com/articles/FST-3-108.php
Amphetamine - AdderallOral.comAmphetamine - AdderallOral.com
Adderall XR is an extended release form of the amphetamine based drug Adderall, which is commonly used in the 21st century to treat Attention Deficit Hyperactivity Disorder and the rare sleeping disorder narcolepsy.. Adderall is a trade name for the drug, which is more commonly known as amphetamine mixed salts and has grown in popularity in recent years following its initial approval for use in the U.S. as an obesity treatment.. Amphetamine mixed salts were first created and approved for use in January 1960 under the brand name Obetrol; the mixture of amphetamine and dextroamphetamine salts is know to have a common side effect of weight loss leading to the drug being used in the first instance as an obesity treatment.. In the 21st century this is not a common use, but some physicians do still prescribe Adderall for those wishing to lose weight. Following the rise of the medical condition known as ADHD a form of amphetamine mixed salts was introduced specifically for treating the condition under ...
https://adderalloral.com/amphetamine/
Role of HDAC inhibition and environmental condition in altering phases of amphetamine self-administrationRole of HDAC inhibition and environmental condition in altering phases of amphetamine self-administration
Gene-environment interactions play a significant role in drug abuse and addiction. Epigenetics (the study of how environmental stimuli alter gene expression) has gained attention in recent years as a significant contributor to many behavioral phenotypes of drug addiction. The current study sought to determine if differential rearing conditions can alter a specific epigenetic mechanism, histone deacetylase (HDAC), and how HDAC inhibition can affect drug-taking and drug-seeking behaviors differently among enriched, isolated, or standard-housed rats. Ninety male Sprague-Dawley rats were reared for 30 days in enriched (EC), isolated (IC), or standard (SC) conditions prior to amphetamine (0.03, 0.05, 0.1 mg/kg/infusion, i.v.) self-administration, extinction, or reinstatement sessions. Trichostatin A (TsA; 0.3 mg/kg, i.v.), an HDAC inhibitor, was injected 30 min prior to drug-taking or drug-seeking sessions. Results indicated that EC rats self-administered less amphetamine (0.03 mg/kg/infusion) than ...
http://krex.k-state.edu/dspace/handle/2097/32694
Effects Of Using Amphetamines And Marijuana Drugs On A Teens Health - hunterpsych.comEffects Of Using Amphetamines And Marijuana Drugs On A Teens Health - hunterpsych.com
Cases Of Hallucination A teenager taking large amount of Amphetamines can suffer from a condition known as Amphetamine psychosis that causes auditory, visual, and tactile hallucinations. The teenager can also suffer from intense paranoia, irrational thoughts and beliefs, mental confusion, and delusions.. Mood Problems Regular intake of amphetamines can cause mood problems like depression, anxiety, dysphoria, aggression etc. Repeated use of amphetamines cause mood swings in teenagers and they exhibit insomnia, restlessness, and irritability. The intensity of the mood swings depend on the amount of amphetamine consumed by teenagers and physiological response to the drug.. Effects Of Marijuana: Marijuana is the most commonly abused drug among teenagers that has various short-term and long-term negative consequences on health.. Elevates Heart Rate And Decreases Blood Pressure Smoking Marijuana increases the heart rate and decreases blood pressure. The heart rate can increase by 20 to 50 beats per ...
https://www.hunterpsych.com/effects-of-using-amphetamines-and-marijuana-drugs-on-a-teens-health/
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Amphetamine - Basemental ModsAmphetamine - Basemental Mods
Overindulging is never a good thing. I am sure your Sim will snort like a responsible adult, but if that is not the case, here are some of the side effects that might occur.. Speed Freak. Sims who keeps on snorting a ton of amphetamine over a prolonged period of time will eventually get an Addicted to Amphetamine buff. This buff lasts for 5 days and is refreshed every time your Sim snorts more amphetamine. If your Sim is not under the influence while the buff is active, he or she might get a lot of negative debuffs until he or she snorts more amphetamine. Your Sim will also loose a lot of weight quite rapidly while addicted.. Overdosing. If your Sim snorts too much amphetamine in the same sitting he or she might experience a non-fatal or fatal OD. Fatal ODs are much less common than non-fatal ones. If your Sim has a non-fatal OD, the energy levels will plummet and he or she will eventually pass out. If your Sim experience a fatal OD, however… Well… Game over.. ...
https://basementalcc.com/amphetamine/
The Neurophile: April 2006The Neurophile: April 2006
Drug-dependent neural plasticity related to drug addiction and schizophrenia can be modeled in animals as behavioral sensitization, which is induced by repeated noncontingent or self-administration of many drugs of abuse. Molecular mechanisms that are critical for behavioral sensitization have yet to be specified. Long-term depression (LTD) of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor (AMPAR)-mediated synaptic transmission in the brain has been proposed as a cellular substrate for learning and memory. The expression of LTD in the nucleus accumbens (NAc) required clathrin-dependent endocytosis of postsynaptic AMPARs. NAc LTD was blocked by a dynamin-derived peptide that inhibited clathrin-mediated endocytosis or by a GluR2-derived peptide that blocked regulated AMPAR endocytosis. Systemic or intra-NAc infusion of the membrane-permeable GluR2 peptide prevented the expression of amphetamine-induced behavioral sensitization in the rat. ...
http://neurophile.blogspot.com/2006_04_01_archive.html
Involvement of the endogenous opioid system in the beneficial influence of physical exercise on amphetamine-induced addiction...Involvement of the endogenous opioid system in the beneficial influence of physical exercise on amphetamine-induced addiction...
Psychostimulant drugs addiction is a chronic public health problem and individuals remain susceptible to relapses increasing public expenses even after withdrawal and treatment. Our research group has focused on finding new therapies to be employed in drug addiction treatment, suggesting the physical exercise as a promising tool. This way, it is necessary to know the mechanisms involved in the beneficial influences of physical exercise observing the pathway that could be explored in drug addiction treatment. Male Wistar rats were conditioned with amphetamine (AMPH) following the conditioned place preference (CPP) protocol and subsequently submitted to swimming for 5 weeks (1 h per day, 5 days per week). Half of the animals were injected with Naloxone (0.3 mg/mL/kg body weight, i.p.) 5 min prior each physical exercise day. After AMPH-CPP re-exposure, our outcomes showed that physical exercise, in addition to minimizing the relapse behavior in the CPP, it increased D1R, D2R and DAT in the Ventral ...
https://www.physiciansweekly.com/involvement-of-the-endogenous-opioid-system-in-the-beneficial-influence-of-physical-exercise-on-amphetamine-induced-addiction-parameters/
Amphetamine: Differentiation by d and I Isomers of Behavior Involving Brain Norepinephrine or Dopamine | ScienceAmphetamine: Differentiation by d and I Isomers of Behavior Involving Brain Norepinephrine or Dopamine | Science
d-Amphetamine is markedly more potent an inhibitor of catecholamine uptake by norepinephrine neurons in the brain than is 1-amphetamine, whereas the two isomers are equally active in inhibiting catecholamine uptake by the dopamine neurons of the corpus striatum. In behavioral studies, d-amphetamine is ten times as potent as 1-amphetamine in enhancing locomotor activity, while it is only twice as potent in eliciting a compulsive gnawing syndrome. This suggests that the locomotor stimulation induced by amphetamine involves central norepinephrine, while dopamine neurons play an important role in the induced compulsive gnawing behavior. Assessment of differential actions of d- and 1-amphetamine may be an efficient method to differentiate behaviors involving norepinephrine or dopamine in the brain. ...
http://science.sciencemag.org/content/168/3938/1487
Amphetamine use disorder prevalence - HumanProgressAmphetamine use disorder prevalence - HumanProgress
Prevalence is defined as the number of cases of a given disease in a specified population at a designated time per 100,000 people. Amphetamine dependence is a substance-related disorder involving a dysfunctional pattern of amphetamine use. Included in the GBD disease modelling were cases meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) or the International Classification of Diseases (ICD-10) diagnostic criteria for amphetamine dependence (DSM: 304.40; ICD: F15.2), excluding those cases due to a general medical condition. According to DSM-IV TR criteria, dependence involves a maladaptive pattern of substance use leading to clinically significant impairment or distress.. ...
https://www.humanprogress.org/dataset/amphetamine-use-disorder-prevalence/
Amphetamine, past and present - a pharmacological and clinical perspective | Renasci | RenasciAmphetamine, past and present - a pharmacological and clinical perspective | Renasci | Renasci
Amphetamine was discovered over 100 years ago. Since then, it has transformed from a drug that was freely available without prescription as a panacea for a broad range of disorders into a highly restricted Controlled Drug with therapeutic applications restricted to attention deficit hyperactivity disorder (ADHD) and narcolepsy. This review describes the relationship between chemical structure and pharmacology of amphetamine and its congeners. Amphetamines diverse pharmacological actions translate not only into therapeutic efficacy, but also into the production of adverse events and liability for recreational abuse. Accordingly, the balance of benefit/risk is the key challenge for its clinical use. The review charts advances in pharmaceutical development from the introduction of once-daily formulations of amphetamine through to lisdexamfetamine, which is the first d-amphetamine prodrug approved for the management of ADHD in children, adolescents and adults. The unusual metabolic route for ...
https://www.renasci.co.uk/publications/amphetamine-past-and-present-a-pharmacological-and-clinical-perspective/
How Long Does Amphetamine Withdrawal Last If I Only Use Occasionally?How Long Does Amphetamine Withdrawal Last If I Only Use Occasionally?
Even if you only use drugs occasionally, other factors such as dosage amount and length of time using can affect how long amphetamine withdrawal lasts.
https://amphetamines.com/withdrawal/how-long-does-amphetamine-withdrawal-last-if-i-only-use-occasionally/
Cross-sensitization/tolerance between wheel running and amphetamine an by Clint InksterCross-sensitization/tolerance between wheel running and amphetamine an by Clint Inkster
Two experiments were conducted to determine whether cross-sensitization/tolerance between wheel running and the drugs amphetamine and morphine is possible in male Sprague Dawley rats. Each experiment compared a non-wheel control group and a chronic wheel access group of rats. Following a 24 day period of wheel access all animals were presented with a drug and saline challenge test (counterbalanced) with either 1 mg/kg of amphetamine (Experiment 1) or 10mg/kg or morphine (Experiment 2). Prior to the challenge tests all animals were habituated to the novel testing environment in two 1 hr sessions (Experiment 1) or one 2 hr session (Experiment 2) to attenuate the acute motoric response to a novel environment. Behavioral sensitization/tolerance was measured by locomotion (cm) within long narrow activity boxes with the Ethnovision video tracking system. In the first experiment the wheel access rats were significantly more active during the 1 hr amphetamine challenge test than the non-wheel rats thus showing
http://scholars.wlu.ca/etd/785/
Strain-dependent behavioural sensitization to amphetamine: Role of environmental influences<...
TY - JOUR. T1 - Strain-dependent behavioural sensitization to amphetamine. T2 - Role of environmental influences. AU - Cabib, S.. PY - 1993. Y1 - 1993. N2 - Repeated daily pairings of 1 mg/kg of amphetamine and test environment induced a large, significant increase of locomotion in mice of the C57BL/6 strain, while a slight, non-significant increase was observed in mice of the DBA to amphetamine in the test cages when the drug was repeatedly administered in their home cage. Moreover, C57BL/6 but not DBA/2 mice showed conditioned hyperactivity. Subsequently six daily pairings of saline and test cage produced a slight, non-significant reduction of the hyperactive response shown by C57BL/6 mice, accompanied by a further increase in the behavioural effect of amphetamine. Finally, a similar, significant context-independent sensitization (unpaired vs control) was observed in mice of the two strains subjected to pairings of saline with the test cage; while context-dependent sensitization (paired vs ...
https://moh-it.pure.elsevier.com/en/publications/strain-dependent-behavioural-sensitization-to-amphetamine-role-of
Patent US5135863 - Compositions and methods for determining the presence of amphetamines in a ... - Google PatentsPatent US5135863 - Compositions and methods for determining the presence of amphetamines in a ... - Google Patents
The instant invention is directed toward an immunoassay which can determine the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine by employing at least two conjugates, each comprised of a functionally similar label bound to an amphetamine analog and a methamphetamine analog respectively and an antibody to amphetamine and an antibody to methamphetamine wherein at least one of the antibodies is a monoclonal antibody.
http://www.google.com/patents/US5135863?dq=ininventor:oliver+ininventor:steele
10,000 American Toddlers now Taking Amphetamine Based ADHD Drugs - The Anti-Media10,000 American Toddlers now Taking Amphetamine Based ADHD Drugs - The Anti-Media
The American Academy of Pediatrics doesnt even have guidelines for amphetamine prescription for children below 4 years old. However, it can be expected that at such a young age, children will quickly develop a dependence on these drugs, setting the state for addiction to other amphetamines later in life including methamphetamine.. That is exactly what happens to a lot of people who use amphetamines, methamphetamine. Just imagine how badly a human being would be messed up if they did amphetamines starting at age 2.. A recent survey found that 7.5% of children ages 6-17 are currently on prescription medications for some type of mental illness, ADHD medications make up 80% of them.. This has to stop. It seems in American society today, the gap between the consciousness levels of people is getting wider. In other words, it seems a certain part of our population is getting more and more aware, intelligent, conscious, and deliberate of their actions. At the same time, another part of our population ...
http://theantimedia.org/10000-american-toddlers-now-taking-amphetamine-based-adhd-drugs/amp/
Amphetamines reverse Parkinsons disease symptoms in mice ( Amphetamines including the drug popula...)Amphetamines reverse Parkinsons disease symptoms in mice ( Amphetamines including the drug popula...)
Amphetamines including the drug popularly known as Ecstasy can rever...The researchers caution that the findings in animals do not suggest Pa...The new study also shows that amphetamines -- normally thought to act ...Parkinsons disease stems from the degeneration of neurons in a brain ...The researchers led by James B. Duke professor of cell biology Marc C...,Amphetamines,reverse,Parkinsons,disease,symptoms,in,mice,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
http://www.bio-medicine.org/biology-news/Amphetamines-reverse-Parkinsons-disease-symptoms-in-mice-1689-1/
Download A Laboratory History of Narcotics Vol. 1: Amphetamines and by Jared Ledgard PDF - Farmers Market Book ArchiveDownload A Laboratory History of Narcotics Vol. 1: Amphetamines and by Jared Ledgard PDF - Farmers Market Book Archive
A Laboratory historical past of Narcotics Vol 1 is a progressive booklet that covers the pharmaceutical training of amphetamines and amphetamine derivatives. This most up-to-date publication through Jared Ledgard has reached one other plateau of element, and excellence within the quarter of laboratory technological know-how. The e-book encompasses a large choice of pharmaceutical procedures, and is by means of a ways certainly one of Jareds maximum works. A Laboratory heritage of Narcotics, vol. 1 will propel you right into a digital labyrinth of psychedelic chemistry and stimulants. in the event you imagine you recognize anything approximately amphetamines and derivatives, your flawed. This ebook will open your eyes to the true international of amphetamines and spinoff medications. essential ebook for anyones reference assortment and past. The publication is a wonderful reference for researchers, scholars, fanatics, and simply undeniable individuals with a interest to know ...
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Chapter 4: Amphetamines, ecstasy and other psychotropic drugsChapter 4: Amphetamines, ecstasy and other psychotropic drugs
81) See Interpreting seizures and other market data.. (82) The number of laboratories dismantled reported in different countries reflects, in addition to the number of production sites, law enforcement activities and priorities as well as reporting practices.. (83) This situation should be checked against 2004 data for the United Kingdom when available. Data on both number of amphetamine seizures and quantities of amphetamine seized in 2004 were not available for Ireland and the United Kingdom; data on quantities of amphetamine seized were not available for Slovenia in 2004; data on number of amphetamine seizures were not available for the Netherlands in 2004. For estimating purposes, 2004 missing data were replaced by 2003 data. Data on quantities seized in 2004 provided by the Netherlands were only estimates, which could not be included in the analysis of trends to 2004.. (84) See Table SZR-11 in the 2006 statistical bulletin.. (85) See Table SZR-12 in the 2006 statistical bulletin.. (86) ...
http://ar2006.emcdda.europa.eu/en/page008-en.html
Alterations in subcellular expression of acid-sensing ion channels in the rat forebrain following chronic amphetamine...
TY - JOUR. T1 - Alterations in subcellular expression of acid-sensing ion channels in the rat forebrain following chronic amphetamine administration. AU - Suman, Ajay. AU - Mehta, Bhavi. AU - Guo, Ming Lei. AU - Chu, Xiang Ping. AU - Fibuch, Eugene E.. AU - Mao, Li Min. AU - Wang, John Q.. PY - 2010/9. Y1 - 2010/9. N2 - Acid-sensing ion channels (ASICs) are densely expressed in broad areas of mammalian brains and actively modulate synaptic transmission and a variety of neuronal activities. To explore whether ASICs are linked to addictive properties of drugs of abuse, we investigated the effect of the psychostimulant amphetamine on subcellular ASIC expression in the rat forebrain in vivo. Repeated administration of amphetamine (once daily for 7 days, 1.25. mg/kg for days 1/7, 4. mg/kg for days 2-6) induced typical behavioral sensitization. At a 14-day withdrawal period, ASIC1 protein levels were increased in the defined surface and intracellular compartments in the striatum (both caudate putamen ...
https://experts.nebraska.edu/en/publications/alterations-in-subcellular-expression-of-acid-sensing-ion-channel
Many Teenagers Unaware That Adderall Is an Amphetamine | Physicians Weekly for Medical News, Journals & ArticlesMany Teenagers Unaware That Adderall Is an Amphetamine | Physicians Weekly for Medical News, Journals & Articles
THURSDAY, Oct. 26, 2017 (HealthDay News) - Adolescents appear to underreport their nonmedical amphetamine use, which may be in part due to lacking awareness that Adderall is an amphetamine, according to a study published online Oct. 23 in Drug and Alcohol Dependence.. Joseph J. Palamar, Ph.D., M.P.H., from New York University Langone Medical Center, and Austin Le, from New York University College of Dentistry, examined self-reported nonmedical Adderall and amphetamine use in a nationally representative sample of 24,740 high school seniors participating in the Monitoring the Future study (2010-2015). They analyzed prevalence and correlates of discordant responses among past-year Adderall users, defined as reporting past-year nonmedical Adderall use but not past-year nonmedical amphetamine use.. The researchers found that while 6.9 percent of respondents reported nonmedical Adderall use and 7.9 percent reported nonmedical amphetamine use, 28.7 percent of Adderall users reported no amphetamine use. ...
https://www.physiciansweekly.com/many-teenagers-unaware-that-adderall-is-an-amphetamine/
Many Teenagers Unaware That Adderall Is an AmphetamineMany Teenagers Unaware That Adderall Is an Amphetamine
THURSDAY, Oct. 26, 2017 (HealthDay News) -- Adolescents appear to underreport their nonmedical amphetamine use, which may be in part due to lacking awareness that Adderall is an amphetamine, according to a study published online Oct. 23 in Drug and Alcohol Dependence.. Joseph J. Palamar, Ph.D., M.P.H., from New York University Langone Medical Center, and Austin Le, from New York University College of Dentistry, examined self-reported nonmedical Adderall and amphetamine use in a nationally representative sample of 24,740 high school seniors participating in the Monitoring the Future study (2010-2015). They analyzed prevalence and correlates of discordant responses among past-year Adderall users, defined as reporting past-year nonmedical Adderall use but not past-year nonmedical amphetamine use.. The researchers found that while 6.9 percent of respondents reported nonmedical Adderall use and 7.9 percent reported nonmedical amphetamine use, 28.7 percent of Adderall users reported no amphetamine ...
https://www.emedevents.com/medical-news/many-teenagers-unaware-that-adderall-is-an-amphetamine-727880
Amphetamines - History, Ice, Action, Physical And Psychological Effects, Treatment - Pills, Diet, Prolonged, and Street ...
Amphetamines are a group of nervous system stimulants that includes amphetamine, dextroamphetamine, and methamphetamine. They are used to induce a state of alert wakefulness and euphoria, and since they inhibit appetite, they also serve as diet pills. After World War II, they were widely prescribed by physicians as diet pills, but they are generally no longer recommended for weight loss programs since there are too many hazards in the prolonged use of amphetamines. Prolonged exposure may result in organ impairment, affecting particularly the kidneys. Amphetamines are addictive and may lead to compulsive behavior, hallucinations, paranoia, and suicidal actions. Their medical use has currently been narrowed to treating only two disorders. One is a condition known as attention-deficit hyperactivity disorder (ADHD) in children. When used to treat overactive children, amphetamines are carefully administered under controlled situations as part of a larger program. The other condition for which ...
http://science.jrank.org/pages/307/Amphetamines.html
Overdose of Amphetamine - Psychiatry AdvisorOverdose of Amphetamine - Psychiatry Advisor
Urine drug screens have limitations, including the generation of false-positive and false-negative results. False-negative results can occur if the amphetamine screening assay has low cross-reactivity for the ingested amphetamine. For example, some amphetamine immunoassays will not detect MDMA use. For this reason, specific MDMA immunoassays are now available.. False-positive results are common in amphetamine immunoassays. Many over-the-counter (OTC) cold and cough medications interfere with amphetamine/methamphetamine screening immunoassays in urine and can trigger positive results.. Active ingredients known to interfere include ephedrine, pseudoephedrine, phentermine, and phenylephrine. In addition, the OTC drug ranitidine and the diet pill tyramine interfere with amphetamine/methamphetamine immunoassay and may trigger positive results. Finally, certain prescription drugs interfere with amphetamine/methamphetamine screening assays. These drugs include buflomedil, chloroquine, chlorpromazine, ...
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Amphetamine is a CNSCentral Nervous System stimulant, producing mild euphoria and an abundance of energy. Amphetamines include both the specific chemical amphetamine and the general class of chemicals which share structural similaries. Amphetamines generally cause strong physical and mental stimulation, keeping users awake and alert for many hours, and some amphetamines cause mood lift / euphoria. Because they increase wakefulness, various amphetamines have been used by the military, by pilots, truck drivers, and other workers to keep functioning past their normal limits. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine. Amphetamine properly refers to the racemic free base, or equal parts of the enantiomers levoamphetamine and dextroamphetamine in their pure amine forms. Nonetheless, the term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. ...
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Amphetamine - TripSit wiki
Amphetamine is a CNSCentral Nervous System stimulant, producing mild euphoria and an abundance of energy. Amphetamines include both the specific chemical amphetamine and the general class of chemicals which share structural similaries. Amphetamines generally cause strong physical and mental stimulation, keeping users awake and alert for many hours, and some amphetamines cause mood lift / euphoria. Because they increase wakefulness, various amphetamines have been used by the military, by pilots, truck drivers, and other workers to keep functioning past their normal limits. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine. Amphetamine properly refers to the racemic free base, or equal parts of the enantiomers levoamphetamine and dextroamphetamine in their pure amine forms. Nonetheless, the term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. ...
https://wiki.tripsit.me/index.php?title=Amphetamine&oldid=5508
Further evaluation of the mechanism by which amphetamine reduces striatal dopamine metabolism: a brain dialysis study. - Oxford...
An intracerebral dialysis method was used in the halothane-anaesthetized rat to further clarify the site which mediates the amphetamine-induced decrease of the striatal dopamine (DA) metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). Following subcutaneous injection of amphetamine (0.1-5.0 mg/kg), DOPAC and HVA in striatal perfusates decreased over the 2 h time course, with 0.5 mg/kg of the drug having maximal effect. In comparison, amphetamine (0.1-5.0 mg/kg) caused a strictly dose-dependent increase of DA in striatal perfusates. Following low (0.1-5.0 mg/kg) but not high (2.0-5.0 mg/kg) doses of amphetamine there was a negative correlation between the increase of DA and decrease of DOPAC in the striatum. Amphetamine (0.5 mg/kg) caused a reduction in DA metabolism in the ibotenic acid-lesioned striatum. Intranigral injection of 10 micrograms, but not of 1 microgram amphetamine, decreased DOPAC (-27%) in the striatal perfusates. However, injection of 1 microgram amphetamine into
https://www.neuroscience.ox.ac.uk/publications/920494
Amphetamines
Amphetamine encompasses various drugs, but you will find methamphetamine is more commonly researched, talked about, and prevalent. Amphetamine is the parent drug of a family of psychostimulants, which speed up the messages going to and from the brain. Some street names for amphetamines include uppers, bennies, black beauties, and diet pills. Amphetamines usually come in powder, pills or tablets. Prescription diet pills also fall into this category of drugs. Amphetamines can be snorted, swallowed, injected, dissolved in a drink, or smoked. A common form of the drug is amphetamine sulphate, more often known as speed.. Another member of this family is methamphetamine, a more potent and more abused version of the drug. Common street names for methamphetamine are meth, speed, crank, and go. A form of methamphetamine is crystalline methamphetamine (ice or crystal meth). Because crystal meth is inexpensive to make and highly addictive, it has become a seriously dangerous drug in ...
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Amphetamines
Amphetamine encompasses various drugs, but you will find methamphetamine is more commonly researched, talked about, and prevalent. Amphetamine is the parent drug of a family of psychostimulants, which speed up the messages going to and from the brain. Some street names for amphetamines include uppers, bennies, black beauties, and diet pills. Amphetamines usually come in powder, pills or tablets. Prescription diet pills also fall into this category of drugs. Amphetamines can be snorted, swallowed, injected, dissolved in a drink, or smoked. A common form of the drug is amphetamine sulphate, more often known as speed.. Another member of this family is methamphetamine, a more potent and more abused version of the drug. Common street names for methamphetamine are meth, speed, crank, and go. A form of methamphetamine is crystalline methamphetamine (ice or crystal meth). Because crystal meth is inexpensive to make and highly addictive, it has become a seriously dangerous drug in ...
https://wernative.worldsecuresystems.com/articles/Amphetamines?A=WebApp&CCID=37422&Page=5&Items=1
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Metabolism and Excretion Amphetamine is reported to be oxidized at the 4 position of the benzene ring to form 4-hydroxy-amphetamine, or on the side chain α or β carbons to form alpha-hydroxy-amphetamine or norephedrine, respectively. Norephedrine and 4-hydroxy-amphetamine are both active and each is subsequently oxidized to form 4-hydroxy-norephedrine. Alpha-hydroxy-amphetamine undergoes deamination to form phenylacetone, which ultimately forms benzoic acid and its glucuronide and the glycine conjugate hippuric acid. Although the enzymes involved in amphetamine metabolism have not been clearly defined, CYP2D6 is known to be involved with formation of 4-hydroxy-amphetamine. Since CYP2D6 is genetically polymorphic, population variations in amphetamine metabolism are a possibility.. Amphetamine is known to inhibit monoamine oxidase, whereas the ability of amphetamine and its metabolites to inhibit various P450 isozymes and other enzymes has not been adequately elucidated. In vitro experiments ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9af67219-9b37-45d0-ac52-647cbfacd296
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Amphetamine is reported to be oxidized at the 4 position of the benzene ring to form 4-hydroxyamphetamine, or on the side chain α or β carbons to form alpha-hydroxy-amphetamine or norephedrine, respectively. Norephedrine and 4-hydroxy-amphetamine are both active and each is subsequently oxidized to form 4-hydroxy-norephedrine. Alpha-hydroxy-amphetamine undergoes deamination to form phenylacetone, which ultimately forms benzoic acid and its glucuronide and the glycine conjugate hippuric acid. Although the enzymes involved in amphetamine metabolism have not been clearly defined, CYP2D6 is known to be involved with formation of 4-hydroxy-amphetamine. Since CYP2D6 is genetically polymorphic, population variations in amphetamine metabolism are a possibility.. Amphetamine is known to inhibit monoamine oxidase, whereas the ability of amphetamine and its metabolites to inhibit various P450 isozymes and other enzymes has not been adequately elucidated. In vitro experiments with human microsomes ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=49b7d111-7045-4116-8988-ba93c7d63491
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Amphetamines | definition of amphetamines by Medical dictionaryAmphetamines | definition of amphetamines by Medical dictionary
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Amphetamine Abuse Symptoms and Signs of amphetamine UseAmphetamine Abuse Symptoms and Signs of amphetamine Use
Learn the behavioral, physical and psychological signs and symptoms of amphetamine abuse now. Amphetamine abuse symptoms - Amphetamines are stimulants that may be prescribed by a doctor to treat several conditions including: Narcolepsy.
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Amphetamines are classified as a stimulant. They work by increasing levels of norepinepherine, serotonin, and dopamine in the brain. Amphetamines are present in ADD medications. It was originally designed as a weight loss drug. It is also commonly used in colleges and high schools as studying and test taking aids. The physical effects of amphetamines are include reduced appetite, increased/distorted sensations, hyperactivity, dilated pupils, flushing, restlessness, dry mouth, erectile dysfunction, headache, tachycardia, increased breathing rate, increased blood pressure, fever, sweating, diarrhea, constipation, blurred vision, impaired speech, dizziness, uncontrollable movements or shaking, insomnia, numbness, palpitations, and arrhythmia. The psychological effects are anxiety and/or general nervousness euphoria, metacognition, creative or philosophical thinking, perception of increased energy, increased sense of well being, increase of goal-orientated thoughts or organized behavior, repetitive ...
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AmphetaminesAmphetamines
Amphetamines are drugs that stimulate the nervous system. They may be used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy (a sleeping disorder), and other conditions. Amphetamines produce increased alertness and a feeling of euphoria. Common amphetamine medicines include dextroamphetamine (Dexedrine) and methamphetamine (Desoxyn). Amphetamines can be misused and are sometimes sold illegally with names such as speed, ice, meth, and lid poppers. ...
https://www.stlukesonline.org/health-services/health-information/healthwise/2017/06/27/13/20/amphetamines
Amphetamines Hurt Male Sexual Performance - The Gazette ReviewAmphetamines Hurt Male Sexual Performance - The Gazette Review
There have been previous studies on this which have shown somewhat mixed results and findings. Some participants have said that their amphetamine use led to a more positive sexual experience, including more sexual desire, and spontaneous erections. However, some people reported negative effects of amphetamines, such as reduced libidos and having a harder time reaching orgasms. The researchers said that there could be a correlation between amphetamine use and the possible psychosocial factors that are experienced by the user. People who use illicit drugs often times have psychcosocial problems, and the drug-use related psychosocial issues could be an explanation for the sexual problems that the user experiences. Social and environmental cues, such as drug use settings can also be factors that affect the sexual response of the user.. While women too can experience some symptoms such as having a harder time reaching orgasm if they are using amphetamines, the largest group impacted by the ...
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Persistent reversal of enhanced amphetamine intake by transient CaMKII inhibition<...
TY - JOUR. T1 - Persistent reversal of enhanced amphetamine intake by transient CaMKII inhibition. AU - Loweth, Jessica A.. AU - Li, Dongdong. AU - Cortright, James J.. AU - Wilke, Georgia. AU - Jeyifous, Okunola. AU - Neve, Rachael L.. AU - Bayer, K. Ulrich. AU - Vezina, Paul. PY - 2013/1/23. Y1 - 2013/1/23. N2 - Amphetamine exposure transiently increases Ca2+/calmodulin-dependent protein kinase II (CaMKII) α expression in the nucleus accumbens (NAcc) shell and this persistently increases local GluA1 S831 phosphorylation and enhances behavioral responding to the drug. Here we assessed whether transiently interfering with CaMKII signaling using a dominant-negative CaMKIIα mutant delivered to the NAcc shell with herpes simplex viral vectors could reverse these long-lasting biochemical and behavioral effects observed following exposure to amphetamine. As expected, transient expression of CaMKIIα K42M in the NAcc shell produced a corresponding transient increase in CaMKIIα and decrease in ...
https://www.researchwithnj.com/en/publications/persistent-reversal-of-enhanced-amphetamine-intake-by-transient-c
Upregulation of Npas4 protein expression by chronic administration of amphetamine in rat nucleus accumbens in vivo<...
TY - JOUR. T1 - Upregulation of Npas4 protein expression by chronic administration of amphetamine in rat nucleus accumbens in vivo. AU - Guo, Ming Lei. AU - Xue, Bing. AU - Jin, Dao Zhong. AU - Liu, Zhen Guo. AU - Fibuch, Eugene E.. AU - Mao, Li Min. AU - Wang, John Q.. PY - 2012/10/24. Y1 - 2012/10/24. N2 - The neuronal PAS domain protein 4 (Npas4) is a transcription factor that is almost exclusively expressed in the mammalian brain. As an activity-dependent transcription factor, Npas4 regulates the transcription of discrete genes and transcriptionally controls the experience-dependent learning and memory. In this study, we explored the impact of the psychostimulant amphetamine (AMPH) on Npas4 protein expression in the rat striatum. We found that acute systemic injection of AMPH had a minimal effect on protein levels of Npas4 in the caudate putamen (CPu) and nucleus accumbens (NAc), while AMPH readily increased protein products of the immediate early gene c-Fos in these regions. In contrast, ...
https://nebraska.pure.elsevier.com/en/publications/upregulation-of-npas4-protein-expression-by-chronic-administratio
Amphetamine Dextroamphetamine DrugAmphetamine Dextroamphetamine Drug
The combination of dextroamphetamine and amphetamine is used as part of a total treatment program for attention deficit hyperactivity disorder (ADHD). It works in the brain to decrease the hyperactivity of patients with this disorder.. Amphetamine-dextroamphetamine is a stimulant and appetite suppressant. It stimulates the central nervous system (nerves and brain) by increasing the amount of certain chemicals in the body. This increases heart rate and blood pressure and decreases appetite, among other effects. The combination of dextroamphetamine and amphetamine comes as a tablet to take by mouth. It is usually taken once or twice daily with or without food.. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dextroamphetamine and amphetamine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.. Dextroamphetamine and amphetamine can be habit-forming. Do ...
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Go here-to there performance after amphetamine: the importance of the response requirement in successive discrimination. |...Go here-to there performance after amphetamine: the importance of the response requirement in successive discrimination. |...
Marmosets were trained on a task involving simultaneous and successive visual discrimination performance where responses were required on all trials. Performance of this task was not affected by low doses of amphetamine. From this it is concluded that amphetamine does not cause a narrowing of attention and that the disruptive effect of amphetamine on the go-no go successive discrimination task already reported is due to a loss of response inhibition rather than to difficulties in the recognition of stimuli presented without a comparison stimulus.. ...
https://scholars.duke.edu/display/pub691473
Multiplex Assay of Amphetamine, Methamphetamine, and Ecstasy Drug using CEDIA® Technology* : Journal of Analytical Toxicology -...
Using Microgenics unique technology, cloned enzyme donor immunoassay (CEDIA), the multiplex assay (CEDIA Amphetamines/Ecstasy) has been developed for the detection of amphetamine, methamphetamine, and ecstasy drugs at cutoff level either of 500 ng/mL or 1000 ng/mL applicable for either qualitative screening or semiquantitative measurement. The multiplex assay detects the total concentration of amphetamine, methamphetamine, and ecstasy drugs in urine samples. In addition, the assay detects metabolites of parent drugs and structurally related drugs including d,l-amphetamine (67.2%), d,l-methamphetamine (58.4%), MDA (113%), MDMA (199%), MDEA (207%), MBDB (123%), BDB (72%), PMA (24%), and PMMA (100%). The assay is highly specific and exhibits minimal cross-reactivity with the undesirable, structurally related over-the-counter amphetaminelike drugs. Imprecision results (n = 120) demonstrate an intra-assay , 6.3% CV and an interassay , 9.2% CV as performed by a modified NCCLS protocol. Using the ...
http://oxfordindex.oup.com/view/10.1093/jat/26.5.267
Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and...Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and...
The pharmacology of novel psychoactive substances is mostly unknown. We evaluated the transporter and receptor interaction profiles of a series of para-(4)-substituted amphetamines and pyrovalerone cathinones. We tested the potency of these compounds to inhibit the norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters (NET, DAT, and SERT, respectively) using human embryonic kidney 293 cells that express the respective human transporters. We also tested the substance-induced efflux of NE, DA, and 5-HT from monoamine-loaded cells, binding affinities to monoamine receptors, and 5-HT2B receptor activation. Para-(4)-substituted amphetamines, including 4-methylmethcathinone (mephedrone), 4-ethylmethcathinone, 4-fluoroamphetamine, 4-fluoromethamphetamine, 4-fluoromethcatinone (flephedrone), and 4-bromomethcathinone, were relatively more serotonergic (lower DAT:SERT ratio) compared with their analogs amphetamine, methamphetamine, and methcathinone. The 4-methyl, 4-ethyl, and 4-bromo ...
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Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, Amphetamine Sulfate - FDA prescribing...Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, Amphetamine Sulfate - FDA prescribing...
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Amphetamine factory discovered in the Czech Republic | The Trip Report
An international scheme to produce and distribute amphetamine was stopped by a joined intervention of Swedish and Czech police, leading to a shutdown of the largest drug laboratory ever found in this part of the world. The lab was located in the Bohemia region and it allegedly served entire Sweden over the period of the last five years, with the total produced in this timeframe estimated at 3.5 tons and a capacity to churn out multi-kilo quantities in a single cycle. Seven people were arrested in relation to the case - four in the Czech Republic and another 3 in Sweden. 700 liters of chemicals used for amphetamine synthesis was discovered at the site, along with 600 liters of waste, while cash, cars and other assets likely acquired through drug trade were confiscated... A Swedish man well-known to the police for his drug activity in the past was supposedly financing the ring, while others arranged for production and transportation of amphetamine into Sweden, where it was predominantly sold. ...
http://the-tripreport.com/site/amphetamine-bust-czech-republic/
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Addiction-Amphetamines | Total Health Recovery ProgramAddiction-Amphetamines | Total Health Recovery Program
and a methyl group adjacent to the phenyl. A large number of chemicals fall into this category, including the club drug MDMA (Ecstasy) and methamphetamine. It is because of the close association with methamphetamine that amphetamine is mistakenly thought of as speed. It is important to note that such an amphetamine class does not technically exist. Phamacodynamically, these drugs all fall under the umbrella of central nervous system stimulants; chemically, they are phenylethylamines. Amphetamine, for example, is methylated phenylethylamine, and methamphetamine is double methylated phenylethylamine.. Amphetamine traditionally comes in the salt-form amphetamine sulphate and is comprised of 50% l- and 50% d-amphetamine (where l- and d- refer to levo and dextro, the two optical orientations the amphetamine structure can have). In the United States, pharmaceutical products containing solely amphetamine (for example, Biphetamine) are no longer manufactured. Today, dextroamphetamine (d-amphetamine) ...
https://totalhealthrecoveryprogram.com/addiction-info/amphetamines/
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Animals and drug treatment protocol. All experimental procedures were performed in accordance with the United States Public Health Service publication Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee at the University of Pittsburgh. A total of 144 male Sprague Dawley rats, consisting of 72 vehicle-treated control rats and 72 rats treated with amphetamine, were used in this study. The control rats were treated with 0.9% saline and were subjected to treatment withdrawal in parallel with each group of the amphetamine-treated rats. One set of rats (n = 42) weighing 150-175 gm at the start of treatment were given daily injections of amphetamine (1-3 mg/kg, i.p.) in their home cages for 2-4 weeks. This dosing protocol has been reported to elicit sensitization with respect to stimulant-evoked locomotor behavior in rats (Robinson and Becker, 1986; Kalivas and Duffy, 1990; Wolf et al., 1994; 1995). A second set of rats (n = 30) were ...
http://www.jneurosci.org/content/20/6/2332
Amphetamines | Psychology Today CanadaAmphetamines | Psychology Today Canada
Amphetamines are a class of central nervous system stimulants with a similar chemical structure, including amphetamine, methamphetamine, dextroamphetamine, ephedrine, and others. Generally, these drugs generate emotional, cognitive, and physical effects, such as increased energy and focus and decreased appetite. They may be prescribed legally for the treatment of ADHD, narcolepsy, or other conditions; they are also used illegally to improve performance, lose weight, or to generate a
https://www.psychologytoday.com/ca/conditions/amphetamines
Differences between Stimulants : Methamphetamine and Amphetamines | Methoide
Although methamphetamine (MA) and other amphetamines can have similar effects, differences also exist. For example, MA has longer lasting and more toxic effects than amphetamine.[1] This is largely because the N-methyl group that differentiates MA from amphetamine decreases the polarity of the molecule, enabling it to better penetrate the blood brain barrier.[2]. In addition, compared with amphetamine, MA has greater activity as a central nervous system (CNS) stimulant while having less peripheral nervous system and cardiovascular stimulation activity. Another difference between amphetamine and MA is that amphetamine stimulates the CNS indirectly by activating the release of catecholamines and inhibiting their breakdown and storage. In contrast, MA stimulates the postsynaptic catecholamine receptors directly.[2] ...
http://methoide.fcm.arizona.edu/infocenter/index.cfm?stid=172
Na+, K+)-ATPase regulation and NaCl intake: effects on circulating inhibitor and sensitivity to noradrenaline | Clinical ScienceNa+, K+)-ATPase regulation and NaCl intake: effects on circulating inhibitor and sensitivity to noradrenaline | Clinical Science
1. These experiments examined the effects of a high NaCl diet on (Na+, K+)-ATPase in kidney, heart and cerebral cortex, on the level of circulating inhibitor of (Na+, K+)-ATPase in plasma, and on stimulation of (Na+, K+)-ATPase by treatment with dextro (d)-amphetamine.. 2. High salt diet increased indices of (Na+, K+)-ATPase activity (K+-activated p-nitrophenylphosphatase activity and ouabain binding) in kidney medulla, prevented stimulation by amphetamine in cerebral cortex and reduced amphetamine stimulation in heart.. 3. High NaCl feeding increased the plasma level of circulating inhibitor of (Na+, K+)-ATPase.. 4. Amphetamine alone had no effect on inhibitor level but amphetamine administration reduced the increase in inhibitor with high NaCl feeding.. ...
http://www.clinsci.org/content/69/4/441
DUMA shows amphetamine use on increase | Australian Institute of CriminologyDUMA shows amphetamine use on increase | Australian Institute of Criminology
|Amphetamine use is increasing, according to a report released by the Australian Institute of Criminology that is based on data from interviews of police detainees in four sites within Australia (Bankstown NSW, East Perth WA, Parramatta NSW and Southport Qld
https://aic.gov.au/publications/cfi/cfi025
Amphetamine abuse abuses the heart - Updated NewsAmphetamine abuse abuses the heart - Updated News
They said their new study adds to evidence about the need to tackle the global stimulant epidemic.. The investigators were led by Stuart Reece, a clinical associate professor at the University of Western Australia. They assessed arterial stiffening in more than 700 Australians in their 30s and 40s. Arteries tend to harden with age.. Those participants who used illegal amphetamines showed greater aging of the arteries than others, including those who smoked tobacco or used the heroin substitute methadone, the study reported.. The link between illegal amphetamine use and greater aging of the arteries was seen in men and women. It was also independent of other risk factors for heart disease and stroke, Reece and his colleagues said.. ...
http://updatednewss.com/tag/jonathan-conricus/amp/
Buy Amphetamine Powder online at affordable rates | Super Chems OnlineBuy Amphetamine Powder online at affordable rates | Super Chems Online
Amphetamine salt/powder: Amphetamine is a potent central nervous system stimulant of the phenethylamine class that is used in the treatment of attention deficit hyperactivity disorder and narcolepsy.
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AmphetamineAmphetamine
The term "amphetamines" also refers to a chemical class, but, unlike the class of substituted amphetamines, the "amphetamines" ... ADZENYS XR-ODT (amphetamine extended-release orally disintegrating tablet) contains a 3 to 1 ratio of d- to l-amphetamine, a ... Following amphetamine uptake at VMAT2, amphetamine induces the collapse of the vesicular pH gradient, which results in the ... DYANAVEL XR contains d-amphetamine and l-amphetamine in a ratio of 3.2 to 1 ... The most common (≥2% in the DYANAVEL XR group ...
https://en.wikipedia.org/wiki/Amphetamine
Amphetamine (disambiguation)Amphetamine (disambiguation)
Look up amphetamine in Wiktionary, the free dictionary. Amphetamine is a stimulant drug. Amphetamine may also refer to: ... "Amphetamine", a song by Everclear from So Much for the Afterglow History and culture of amphetamines This disambiguation page ... amphetamine), the drug's levorotatory enantiomer Adderall, a brand of mixed amphetamine salts Lisdexamfetamine, a prodrug of ... Substituted amphetamine, a class of chemical compounds based upon the amphetamine structure Dextroamphetamine (dexamfetamine, ( ...
https://en.wikipedia.org/wiki/Amphetamine_(disambiguation)
Substituted amphetamineSubstituted amphetamine
Amphetamine was first produced at the end of the 19th century. By the 1930s, amphetamine and some of its derivative compounds ... Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds ... For example, (S)-amphetamine, commonly known as d-amphetamine or dextroamphetamine, displays five times greater psychostimulant ... Examples of substituted amphetamines are amphetamine (itself), methamphetamine, ephedrine, cathinone, phentermine, ...
https://en.wikipedia.org/wiki/Substituted_amphetamine
Amphetamine (film)Amphetamine (film)
Amphetamine (Chinese: 安非他命; Jyutping: on1 fei1 taa1 ming6) is a 2010 Hong Kong film starring Byron Pang and Thomas Price. It ... Byron Pang as Kafka Tom Price as Daniel Linda So as May Winnie Leung as Linda 安非他命_(電影) Amphetamine (film) An uncut version of ... 安非他命》雞姦戲變「黑畫面」准上映 [Amphetamine anal intercourse shots are changed to blackout for public screening]. Ming Pao (in Chinese). 1 ... The next morning, Daniel does amphetamine with Kafka, and Kafka confesses that despite everything he's done wrong, he
https://en.wikipedia.org/wiki/Amphetamine_(film)
Amphetamine dependenceAmphetamine dependence
... refers to a state of psychological dependence on a drug in the amphetamine class. Stimulants such as ... Amphetamine use within teenagers can have lasting effects on their brain, in particular the prefrontal cortex. Amphetamine use ... When substituted amphetamines are used, drug tolerance develops rapidly. Amphetamine dependence has shown to have the highest ... this will combine the amphetamine with a negative thing or opposite stimulus. Treatment for amphetamines is growing at ...
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Amphetamine Reptile RecordsAmphetamine Reptile Records
"Amphetamine Reptile Records Documentary The Color Of Noise". mxdwn.com. 13 October 2015. Retrieved 27 June 2020. "Amphetamine ... Amphetamine Reptile Records (or AmRep Industries) is a record label founded in 1986 by Tom Hazelmyer in Washington state. The ... "Protonic Reversal Ep169: Tom Hazelmyer (Amphetamine Reptile)". protonicreversal.com. 14 May 2020. Retrieved 27 June 2020. ... Amphetamine Reptile Tour - Friday, October 30, 1992, at The Ritz List of record labels Riemenschneider, Chris (October 3, 2005 ...
https://en.wikipedia.org/wiki/Amphetamine_Reptile_Records
Amphetamine type stimulantAmphetamine type stimulant
... amphetamine psychosis. Amphetamine, the parent compound of amphetamine-type stimulants was first synthesized by Romanian ... After its discovery, amphetamine was purified and put into medical use in the 1900s. Amphetamine was originally sold as a ... However, amphetamine-type stimulants is not prescribed for this use legally. Amphetamine is frequently used for pleasure and ... However, the urinary excretion of amphetamine and other ATS is highly dependent on the pH. A small amount of amphetamine is ...
https://en.wikipedia.org/wiki/Amphetamine_type_stimulant
Amphetamine Reptile Records discographyAmphetamine Reptile Records discography
Specific Amphetamine Reptile Records at Discogs (Discographies of American record labels, Amphetamine Reptile Records). ... Amphetamine Reptile Records is an American record label founded in 1986 by American musician Tom Hazelmyer. General " ... "Amphetamine Reptile Records Discography". amphetaminereptile.com. Retrieved June 23, 2020. ...
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Cocaine and amphetamine regulated transcriptCocaine and amphetamine regulated transcript
Cocaine- and amphetamine-regulated transcript, also known as CART, is a neuropeptide protein that in humans is encoded by the ... Amphetamine Cocaine Douglass J, Daoud S (March 1996). "Characterization of the human cDNA and genomic DNA encoding CART: a ... cocaine-+and+amphetamine-regulated+transcript+protein at the US National Library of Medicine Medical Subject Headings (MeSH) ( ... Zhang M, Han L, Xu Y (November 2011). "Roles of cocaine- and amphetamine-regulated transcript in the central nervous system". ...
https://en.wikipedia.org/wiki/Cocaine_and_amphetamine_regulated_transcript
Bread and AmphetaminesBread and Amphetamines
Bread & Amphetamines (Khlyab i amfeti) (Bulgarian: "Хляб и амфети") is the fourth solo studio album by Bulgarian rapper Big Sha ...
https://en.wikipedia.org/wiki/Bread_and_Amphetamines
2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine
... (DOEF; also known as dimethoxyfluoroethylamphetamine) is a lesser-known psychedelic ... Substituted amphetamines, Fluoroethyl compounds, All stub articles, Psychoactive drug stubs). ...
https://en.wikipedia.org/wiki/2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine
History and culture of substituted amphetaminesHistory and culture of substituted amphetamines
"A Synthesis of Amphetamine. J. Chem. Educ. 51, 671 (1974)". Erowid.org. Retrieved 9 January 2011. Otto Snow (2002). Amphetamine ... Land Speed Record is an allusion to Hüsker Dü's amphetamine use.[citation needed] Amphetamine was widely abused in the 1980s ... Asia & Pacific Amphetamine-Type Stimulants Information Centre "Oliver Sacks: on amphetamines, Oliver Sacks Foundation". YouTube ... Other examples include the song "Amphetamine" by Alternative rock band Everclear, "Amphetamine" by Three Souls in My Mind, "20 ...
https://en.wikipedia.org/wiki/History_and_culture_of_substituted_amphetamines
Oussama MellouliOussama Mellouli
However, amphetamines are on the official banned substances list; and can/do help swimming performance. Wikinews has related ... Mellouli has since admitted that he took the ADD medication Adderall, a stimulant and a form of amphetamine. (Already in June ... amphetamine... and other substances with similar chemical structure or similar biological effect(s). (p. 7) This passage ...
https://en.wikipedia.org/wiki/Oussama_Mellouli
Racing thoughtsRacing thoughts
Since amphetamines are a stimulant, use of these drugs result in a state that resembles the manic phase of bipolar disorder and ... Amphetamines are used as a stimulant to trigger the central nervous system, increasing heart rate and blood pressure while ... "Amphetamine". drugs.com. Cerner Multum. April 12, 2009. Archived from the original on November 11, 2014. Retrieved November 11 ... Racing thoughts are also associated with sleep deprivation, hyperthyroidism and the use of amphetamines. Racing thoughts may be ...
https://en.wikipedia.org/wiki/Racing_thoughts
Substantia nigraSubstantia nigra
Amphetamine is similar in structure to dopamine and trace amines; as a consequence, it can enter the presynaptic neuron via DAT ... In addition, amphetamine and trace amines are substrates for the neuronal vesicular monoamine transporter, vesicular monoamine ... "Amphetamine". DrugBank. University of Alberta. 8 February 2013. Retrieved 13 October 2013. Eiden LE, Weihe E (January 2011). " ... Studies have shown that, in certain brain regions, amphetamine and trace amines increase the concentrations of dopamine in the ...
https://en.wikipedia.org/wiki/Substantia_nigra
FluorenolFluorenol
"Amphetamine". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-09-20. Dunn, D.; Hostetler, G.; Iqbal, M.; Marcy, V. R.; Lin, Y. G.; ... The lipophilicity of fluorenol (LogP 2.4) is higher than that of drugs like modafinil (LogP 1.7) and amphetamine (LogP 1.8), ...
https://en.wikipedia.org/wiki/Fluorenol
Warren SonbertWarren Sonbert
His first film, Amphetamine, featured a shock cut to two young men passionately embracing as the camera swooped around them in ... Amphetamine (1966) Where Did Our Love Go? (1966) Hall of Mirrors (1966) The Bad and the Beautiful (1967) Truth Serum (1967) ... "Films: 'Amphetamine'". "Future for the Past: A Tribute to Warren Sonbert & the Estate Project." San Francisco International ...
https://en.wikipedia.org/wiki/Warren_Sonbert
The Heroine SheiksThe Heroine Sheiks
The initial lineup of Selberg, Porfiris, Westberg, and J Bryan Bowden recorded the first single on Amphetamine Reptile records ... cite journal}}: Cite journal requires ,journal= (help) "AR073: The Heroine Sheiks". Amphetamine Reptile. Retrieved May 27, 2008 ... Amphetamine Reptile Records artists, Musical groups from New York (state), Musical groups from Minnesota, Musical groups ... Amphetamine Reptile) "Heroine Sheiks" - (1999, Reptilian) "Best Enemies/Oucha" - (2002, Rubric) Live at The Ottobar - (2005, ...
https://en.wikipedia.org/wiki/The_Heroine_Sheiks
Philip BestPhilip Best
Amphetamine Sulphate. ISBN 978-0-9991825-3-6. "American Campgrounds: Philip Best / Peter Sotos". Archived from the original on ... In 2016, a 60-page chapbook of writings by Best was published by Amphetamine Sulphate. In 2010, a collection of Best's artwork ...
https://en.wikipedia.org/wiki/Philip_Best
Blonde on BlondeBlonde on Blonde
The reference to Baby's penchant for "fog ... amphetamine and ... pearls" suggests Sedgwick or a similar debutante, according ...
https://en.wikipedia.org/wiki/Blonde_on_Blonde
2C-D2C-D
"Amphetamine analogs. II. Methylated phenethylamines". Journal of Medicinal Chemistry. 13 (1): 134-5. doi:10.1021/jm00295a034. ...
https://en.wikipedia.org/wiki/2C-D
LoudhouseLoudhouse
Mog Stunt Team Credits (liner notes). Amphetamine Reptile. AmRep061. Retrieved November 13, 2020. Graff, Gary (April 26, 2018 ... The band was signed to the prominent underground label Amphetamine Reptile Records. Dombroski, the Cross brothers, and Mazzola ...
https://en.wikipedia.org/wiki/Loudhouse
Elevation RecordsElevation Records
"Baby Amphetamine". Archived from the original on 5 October 2007. Retrieved 4 January 2008. Dee, Johnny (1988) "It's Different ...
https://en.wikipedia.org/wiki/Elevation_Records
Beta blockerBeta blocker
Richards JR, Albertson TE, Derlet RW, Lange RA, Olson KR, Horowitz BZ (May 2015). "Treatment of toxicity from amphetamines, ... Handly, Neal (December 16, 2016). "Toxicity, Amphetamine". Medscape. Archived from the original on October 13, 2007. Wyeth ...
https://en.wikipedia.org/wiki/Beta_blocker
Steve Wynn (musician)Steve Wynn (musician)
Wynn's song "Amphetamine" from Static Transmission was re-recorded by the cast of the movie Bandslam and performed in its ... "Amphetamine [Bandslam]". YouTube. Archived from the original on 2021-12-22. Retrieved 21 June 2021. "Crossing Dragon Bridge - ...
https://en.wikipedia.org/wiki/Steve_Wynn_(musician)
Norepinephrine transporterNorepinephrine transporter
Amphetamines have an effect on norepinephrine levels similar to that of cocaine in that they both increase NE levels in the ... Amphetamines cause a large accumulation of extracellular NE. High levels of NE in the brain account for most of the profound ... Amphetamine-like drugs are substrates for monoamine transporters, include NET, that cause a reversal in the direction of ... However, the effects that amphetamines have on the brain are slower but last longer than the effects cocaine has on the brain. ...
https://en.wikipedia.org/wiki/Norepinephrine_transporter
Thomas Price (actor)Thomas Price (actor)
Chase and Amphetamine. Price was the joint lead, with Byron Pang, in the film Amphetamine. He played the character of Daniel. ... Marsh, James (2010-04-07). "HKIFF 2010: Amphetamine Review". Twitch.com. Retrieved 2010-04-08. "S.M.A.R.T. Chase new movie ... Lee, Maggie (2010-03-22). "Amphetamine - Film Review". Hollywoodreporter.com. Retrieved 2010-04-08. ...
https://en.wikipedia.org/wiki/Thomas_Price_(actor)
List of feature films with bisexual charactersList of feature films with bisexual characters
Staff, Thr (14 October 2010). "Amphetamine - Film Review". The Hollywood Reporter. "'Black Swan' lesbian sex scene led to most ...
https://en.wikipedia.org/wiki/List_of_feature_films_with_bisexual_characters
Para-ChloroamphetaminePara-Chloroamphetamine
Ross, S. B.; Ögren, S. O.; Renyi, A. L. (2009). "Substituted Amphetamine Derivatives. I. Effect on Uptake and Release of ... Ögren, S. O.; Ross, S. B. (2009). "Substituted Amphetamine Derivatives. II. Behavioural Effects in Mice Related to ... para-Chloroamphetamine (PCA), also known as 4-chloroamphetamine (4-CA), is a substituted amphetamine and monoamine releaser ... Substituted amphetamines para-Chloromethamphetamine (4-CMA) Chlorphentermine 3,4-Dichloroamphetamine (DCA) 4-Fluoroamphetamine ...
https://en.wikipedia.org/wiki/Para-Chloroamphetamine
Smile (The Beach Boys album)Smile (The Beach Boys album)
... classic amphetamine psychosis. He was taking a lot of amphetamines, in the form of Desbutal, which is methedrine and some ... one of the effects of the amphetamine is the God-like feeling, combined with the fear. The things that you do, you see as ...
https://en.wikipedia.org/wiki/Smile_(The_Beach_Boys_album)
Amphetamine: MedlinePlus Drug InformationAmphetamine: MedlinePlus Drug Information
Amphetamine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking amphetamine,. *tell your doctor and pharmacist if you are allergic to amphetamine, other stimulant medications ... If you or your child are taking amphetamine for ADHD, your doctor will probably start you on a low dose of amphetamine and ... Alcohol can make the side effects from amphetamine worse.. *you should know that amphetamine should be used as part of a total ...
https://medlineplus.gov/druginfo/meds/a616004.html
Browsing by Subject "Amphetamine"
Systematic review of treatment for amphetamine-related disorders  World Health Organization. Management of Substance ...
https://apps.who.int:80/iris/browse?authority=Amphetamine&type=mesh
Amphetamine Toxicity Workup: Laboratory Studies, Imaging Studies, Other TestsAmphetamine Toxicity Workup: Laboratory Studies, Imaging Studies, Other Tests
Synthetic amphetamine compounds commonly are produced in clandestine laboratories and vary in purity and potency. ... Amphetamines are a class of compounds increasingly abused in regions of the world such as the western United States, ... encoded search term (Amphetamine Toxicity) and Amphetamine Toxicity What to Read Next on Medscape ... Amphetamine Toxicity Workup. Updated: Oct 21, 2021 * Author: Neal Handly, MD, MS, MSc; Chief Editor: Jeter (Jay) Pritchard ...
https://www.medscape.com/answers/812518-199554/what-is-the-role-of-imaging-studies-in-the-workup-for-amphetamine-toxicity
Amphetamine-Related Psychiatric Disorders: Background, Pathophysiology, EpidemiologyAmphetamine-Related Psychiatric Disorders: Background, Pathophysiology, Epidemiology
Amphetamine-induced anxiety disorder Amphetamine-induced mood disorder Amphetamine-induced psychotic disorder with delusions ... Amphetamine-induced psychosis results after increased use of amphetamines, as observed in binge use or after protracted use. ... Prescription amphetamines induce the release of dopamine in a dose-dependent manner; low doses of amphetamines deplete large ... Amphetamine use may elicit or be associated with the recurrence of other psychiatric disorders. People addicted to amphetamines ...
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Browsing by Subject AmphetamineBrowsing by Subject "Amphetamine"
Systematic review of treatment for amphetamine-related disorders  World Health Organization. Management of Substance ...
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Notes from the Field: Amphetamine Use Among Workers with Severe Hyperthermia - Eight States, 2010-2019 | MMWRNotes from the Field: Amphetamine Use Among Workers with Severe Hyperthermia - Eight States, 2010-2019 | MMWR
This report describes cases of workers who developed heat-related illnesses after taking amphetamines and working in a hot ... This report describes cases of workers who developed heat-related illnesses after taking amphetamines and working in a hot ... and four qualitative screening tests detected amphetamine or amphetamine analogs in workers without amphetamine prescriptions. ... The most common medically important amphetamine-class substances are amphetamine and its two enantiomers (levoamphetamine and ...
https://www.cdc.gov/mmwr/volumes/69/wr/mm6930a5.htm
Amphetamine on the Mac App StoreAmphetamine on the Mac App Store
... see screenshots and learn more about Amphetamine. Download Amphetamine for macOS 10.11 or later and enjoy it on your Mac. ... Welcome to Amphetamine, the most awesome keep-awake app ever created for macOS. Amphetamine can keep your Mac, and optionally ... What Else Does Amphetamine Do? === Amphetamine is the most powerful and customizable keep-awake utility ever created for macOS ... Amphetamine requires macOS 10.11 El Capitan or higher; some features require a higher version of macOS. • Amphetamine supports ...
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Amphetamine Reptile - BrooklynVegan ? Page 2Amphetamine Reptile - BrooklynVegan ? Page 2
Amphetamine Reptile. upcoming Lubricated Goat Woman, Pink Reason, other shows. upcoming Lubricated Goat Woman, Pink Reason, ... Arab on Radar playing Dudefest 2010 in Indiana, Amphetamine Reptile celebrating 25 years in Minneapolis (both lineups). Arab on ... Arab on Radar playing Dudefest 2010 in Indiana, Amphetamine Reptile celebrating 25 years in Minneapolis (both lineups). ...
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Substance use - amphetamines | Lima Memorial Health SystemSubstance use - amphetamines | Lima Memorial Health System
Substance use - amphetamines. Substance abuse - amphetamines; Drug abuse - amphetamines; Drug use - amphetamines. ... There are different kinds of street amphetamines. Common ones and some of their slang terms are:. *Amphetamine: goey, louee, ... Some people use amphetamines to help them stay awake on the job or to study for a test. Others use them to boost their ... Amphetamines are drugs. They can be legal or illegal. They are legal when they are prescribed by a doctor and used to treat ...
https://www.limamemorial.org/health-library/HIE%20Multimedia/60/000792
Mesoaccumbens dopamine and the self-administration of amphetamineMesoaccumbens dopamine and the self-administration of amphetamine
... Ann N Y Acad Sci. 1999 Jun 29;877:820-2. doi: 10.1111/j.1749- ...
https://pubmed.ncbi.nlm.nih.gov/10415712/
Amphetamine - HealthLibrary
Before taking amphetamine,. *tell your doctor and pharmacist if you are allergic to amphetamine, other stimulant medications ... If you or your child are taking amphetamine for ADHD, your doctor will probably start you on a low dose of amphetamine and ... Alcohol can make the side effects from amphetamine worse.. *you should know that amphetamine should be used as part of a total ... If you are taking amphetamine for narcolepsy, your doctor will probably start you on a low dose of amphetamine and increase ...
http://healthlibrary.epnet.com/GetContent.aspx?token=3e5dbc25-ab4e-4419-a847-31a4e7a92e96&chunkiid=1058491
Amphetamine Addiction: 5 Signs You May Have a ProblemAmphetamine Addiction: 5 Signs You May Have a Problem
Here are the top signs that you may have an addiction to amphetamines. ... Are you misusing amphetamines? Here are the top signs that you may have an addiction to amphetamines. ... Amphetamine Addiction: 5 Signs You May Have a Problem By Stefanie Sandler Billette, MS, ACE-CHC. Medically Reviewed by Yilang ... Using an amphetamine in a way that your prescribing medical provider did not intend may be a sign of addiction. ...
https://www.webmd.com/connect-to-care/addiction-treatment-recovery/prescription/signs-of-amphetamine-addiction
Amphetamine regimen does not improve post-stroke motor recoveryAmphetamine regimen does not improve post-stroke motor recovery
A pilot clinical trial exploring the benefit of d-amphetamine combined with physical therapy for stroke patients found no ... Tags: Amphetamine, Brain, Clinical Trial, Depression, Efficacy, Fatigue, Frequency, Ischemic Stroke, Mental Health, Neurology, ... Amphetamine regimen does not improve post-stroke motor recovery. *Download PDF Copy ... Amphetamines were first synthesized in 1887 by Romanian chemist Lazar Edeleanu, but it wasnt until the late 1920s that ...
https://www.news-medical.net/news/20180827/Amphetamine-regimen-does-not-improve-post-stroke-motor-recovery.aspx
WHO EMRO | Use of amphetamine-type stimulants in the Islamic Republic of Iran, 2004-2015: a review | Volume 23, issue 3 | EMHJ...
Use of amphetamine-type stimulants in the Islamic Republic of Iran, 2004-2015: a review ... ABSTRACT Amphetamine-type stimulants (ATS) are the second most commonly used illicit drugs in the world, after cannabis. The ... Amphetamine-type stimulants (ATS) are one of the main forms of stimulant drugs. Most ATS are chemical compounds synthesized ... In Australia, the use amphetamines more than 5 times in the past year was in found 3.9% of the population aged 15 to 64 and ATS ...
http://www.emro.who.int/emhj-volume-23-2017/volume-23-issue-3/use-of-amphetamine-type-stimulants-in-the-islamic-republic-of-iran-20042015-a-review.html
D-amphetamine (Dexedrine; Adderal) = Serotonin? linkadge | Psycho-Babble
All in all, most of the literature I found states that amphetamine releases serotonin. You were right (as usual... ... D-amphetamine (Dexedrine; Adderal) = Serotonin? linkadge SLS 5/2/12. *D-amphetamine (Dexedrine; Adderal) = Serotonin? linkadge ... Amphetamine was the weakest at increasing extracellular serotonin. This is not an insignificant finding. However, again, it is ... D-amphetamine (Dexedrine; Adderal) = Serotonin? linkadge. Posted by SLS on May 2, 2012, at 7:05:49 ...
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Saudi Arabia seizes record 47 million amphetamine pills hidden in flour shipment | CNNSaudi Arabia seizes record 47 million amphetamine pills hidden in flour shipment | CNN
Authorities in Saudi Arabia have confiscated 47 million amphetamine pills which were hidden in a flour shipment, in an ... Some 47 million amphetamine pills hidden in a flour shipment were seized by Saudi Arabias authorities. ... The United Nations Office on Drugs and Crime (UNODC) previously said "reports of amphetamine seizures from countries in the ... Authorities in Saudi Arabia have confiscated 47 million amphetamine pills which were hidden in a flour shipment, in an ...
https://edition.cnn.com/2022/09/01/middleeast/saudi-arabia-amphetamine-intl-scli/index.html
Will meclizine make you test positive for amphetamine in your urine?Will meclizine make you test positive for amphetamine in your urine?
... amphetamine, meclizine - Answer: no its for nausea and allergies it will not make you test positive for... ... Will meclizine make you test positive for amphetamine in your urine?. Question posted by family partner on 27 Oct 2010 ... Is there a otc nasal spray that may show positive results for amphetamines in a urine test?. Updated 30 May 2010 1 answer ... After taking sudafed why did I have a positive amphetamine urine test?. Updated 14 April 2010 1 answer ...
https://www.drugs.com/answers/will-meclizine-make-you-test-positive-for-332036.html
Amphetamine Use Soars in Locked Down Finland: Study | Courthouse News ServiceAmphetamine Use Soars in Locked Down Finland: Study | Courthouse News Service
Amphetamine Use Soars in Locked Down Finland: Study. Finns may be known for their love of vodka and beer, but growing numbers ... Amphetamines can be used to treat medical conditions such as ADHD, but is also taken recreationally, sometimes under the name " ... Use of amphetamines in the country of 5.5 million people has tripled since 2013 according to wastewater studies, Gunnar said. ... Although researchers could not directly link the spike in drug use to the lockdown, "the fact remains that amphetamine use has ...
https://www.courthousenews.com/amphetamine-use-soars-in-locked-down-finland-study/
Mixed amphetamine salts | CADTHMixed amphetamine salts | CADTH
Stay up to date on the latest from CADTH, and subscribe to our newsletter ...
https://www.cadth.ca/mixed-amphetamine-salts-1
NIOSHTIC-2 Publications Search - 20029910 - Temperature and neurotoxicity - lessons from the amphetamines.NIOSHTIC-2 Publications Search - 20029910 - Temperature and neurotoxicity - lessons from the amphetamines.
... our work examining the neurotoxicity of the substituted amphetamines (SAs) (e.g., amphetamine, methamphetamine, MDMA, ... our work examining the neurotoxicity of the substituted amphetamines (SAs) (e.g., amphetamine, methamphetamine, MDMA, ... within the Rave dance culture and interest in its use as a psychotherapy adjunct as well as treatment of ADHD with amphetamine ...
https://www.cdc.gov/niosh/nioshtic-2/20029910.html
Amphetamine - wikidocAmphetamine - wikidoc
Amphetamine derivatives, often referred to as "amphetamines" or "substituted amphetamines", are a broad range of chemicals that ... Although there are a variety of amphetamines and amphetamine derivatives, the word "amphetamines" in this review stands for ... amphetamine sulfate, and amphetamine aspartate"[29]) is excessively long, this article exclusively refers to this amphetamine ... "Amphetamine. Chemspider. Retrieved 6 November 2013.. *↑ "Chemical and Physical Properties". Amphetamine. PubChem Compound. ...
https://www.wikidoc.org/index.php/Amphetamine
Erowid Experience Vaults: Amphetamines Reports in category: Bad TripsErowid Experience Vaults: Amphetamines Reports in category: Bad Trips
A list of experiences with Amphetamines in category Bad Trips ... Amphetamines. Jul 24 2006. Agony Of Speeding In The UK. UKOK. ... Amphetamine (Adderall). Sep 11 2001. A Psychotic Trip to Hell Itself. Unknown. Cocaine, Amphetamines, Ketamine & LSD. Jun 6 ... LSD, Amphetamines, Cannabis, Alcohol & MDMA. Sep 16 2005. World of Elves and Cops. JoJo. Amphetamines (Adderall) & Alcohol. Mar ... Amphetamines (Dexedrine). Oct 1 2009. Ruined It. MaryJaneGangsta. Cannabis, Amphetamines (Adderall) & Sleep Deprivation. May 24 ...
https://www.erowid.org/experiences/subs/exp_Amphetamines_Bad_Trips.shtml
Erowid.org: Erowid Reference 1077 : Another Abusable Amphetamine : Jackson B, Reed A JrErowid.org: Erowid Reference 1077 : Another Abusable Amphetamine : Jackson B, Reed A Jr
Over the past six months the abuse of yet another type of amphetamine has come to our attention. The drug is ... Reed A Jr Another Abusable Amphetamine JAMA 1970 211(5):830 ...
https://erowid.org/references/refs_view.php?ID=1077&C=MDMA&S=QgIUrsaMBXkrwvvgw
3 Bangor residents arrested for alleged sale of fentanyl, amphetamines3 Bangor residents arrested for alleged sale of fentanyl, amphetamines
Douglas Morris, 31, Shannon Jenkins, 45, and Christopher Harvey, 48 were arrested on Class A charges of aggravated trafficking in schedule W drugs following an investigation into an apartment located on Bolling Drive.
https://www.bangordailynews.com/2021/11/05/news/bangor/3-bangor-residents-arrested-for-alleged-sale-of-fentanyl-amphetamines/
Mark Maynard | Amphetamine ReptileMark Maynard | Amphetamine Reptile
Posted in Art and Culture, Uncategorized , Also tagged 1975, 1980, Al Dewey, amphetamines, Chicago, coffins, decapitation, ...
http://markmaynard.com/tag/amphetamine-reptile/
Amphetamines: What Parents Need to Know (for Parents) - Print Version - Helen DeVos Childrens HospitalAmphetamines: What Parents Need to Know (for Parents) - Print Version - Helen DeVos Children's Hospital
Amphetamines: What Parents Need to Know. What It Is:. Amphetamines are very addictive stimulants. They speed up functions in ... Amphetamines are swallowed, smoked, snorted, or injected.. What It Does:. No matter how a person takes amphetamines, these ... Even after users stop taking amphetamines, they may still have problems such as aggression, anxiety, and strong cravings for ...
https://www.kidshealth.org/DevosChildrens/en/parents/drugs-amphetamines.html?view=ptr&WT.ac=p-ptr
Bath Salts - An Amphetamine by Any Other Name - Vista TaosBath Salts - An Amphetamine by Any Other Name - Vista Taos
Speed, meth, amphetamines, Ecstasy are highly addictive and quite simply very bad for human and animal consumption. They have ... Bath Salts - An Amphetamine by Any Other Name. Blake Browder2021-06-03T21:52:38+00:00 ... Methyl derivatives come from theme and variation of the molecular compound of amphetamine, adding hydrogen and carbon molecules ...
https://www.vistataos.com/bath-salts-an-amphetamine-by-any-other-name/
UkrainianUkrainian
Here are some signs and symptoms of amphetamine abuse and how you can help someone overcome their addiction to amphetamines. ... Amphetamine-caused psychosis. Some people who abused this drug would wear themselves out with amphetamine binges, taking the ... Signs and Symptoms of Amphetamine Abuse. Amphetamine is a strong stimulant that has been used medically for situations when a ... Getting Through a Withdrawal from Amphetamine. Long-term amphetamine abusers are likely to be severely malnourished and ...
https://www.narconon.org/uk/drug-abuse/amphetamine-signs-symptoms.html
Gentech Addtabz reviews: Is this Ampheta-CDP choline supplement the closest legal Adderall, amphetamine substitute? - SF WeeklyGentech Addtabz reviews: Is this Ampheta-CDP choline supplement the closest legal Adderall, amphetamine substitute? - SF Weekly
Common amphetamines found in products that contain Adderall/amphetamines besides amphetamine and metamphetamine are going to ... And not all amphetamines are good for psychological stimulation. Some are better for sympathetic nervous system stimulation to ... Gentech Addtabz reviews: Is this Ampheta-CDP choline supplement the closest legal Adderall, amphetamine substitute?. by Sponsor ... The company makes their blend Ampheta-CDP sound like it is similar to amphetamine. If its not a substituted phenethylamine, it ...
https://www.sfweekly.com/sponsored/gentech-addtabz-reviews-is-this-ampheta-cdp-choline-supplement-the-closest-legal-adderall-amphetamine-substitute/
Amphetamine withdrawal and depressionAmphetamine withdrawal and depression
Amphetamines Define Amphetamines History of Amphetamines Amphetamines Effects Amphetamines Facts Amphetamines Street Names List ... Amphetamine Addiction Amphetamine Abuse Amphetamine Withdrawal Amphetamine Detox Amphetamine Addiction Treatment Amphetamines ... Amphetamines Articles and Refs. * Cocaine or Amphetamines: Which Recovery Program is More Difficult? ... Amphetamines.com IN PARTNERSHIP WITH AMERICAN ADDICTION CENTERS Copyright © 2022 Amphetamines.com. All Rights Reserved. ...
https://amphetamines.com/depression/
MethamphetamineStimulantsAdderallCentral nervous system sPositive for amphetaminesSaltsDopamineAddictiveADHDStop taking ampheDrugsAttention deficitRatsResponse to amphetamineEffects of AmphetaminesCocaine and amphetaminesContain amphetamineStreet amphetaminesAmerican Addiction CentersDosesNarcolepsyAbuseDisordersRitalinPrescriptionAddiction treatmentMedicationInhalersSynthesized in 1887Chemically relatedUppersIntoxicationSerotonin releaseLocomotorDerivativesMarkedly reducedPleasurable effectsPillsSubstanceReptilePhenethylamineKeep-awake utilityDrugAnxietyLockdownStay awakeLevoamphetamineUptakeUrine testStimulationDisorderEuphoriaMisuseStriatalPsychostimulantsWithdrawal symptoms
Methamphetamine16
  • However, with methamphetamine and other designer amphetamines, peripheral effects may not be observed. (medscape.com)
  • Psychophysiological aspects of amphetamine-methamphetamine abuse. (medscape.com)
  • three postmortem blood assays detected methamphetamine, and four qualitative screening tests detected amphetamine or amphetamine analogs in workers without amphetamine prescriptions. (cdc.gov)
  • our work examining the neurotoxicity of the substituted amphetamines (SAs) (e.g., amphetamine, methamphetamine, MDMA, fenfluramine) illustrate how temperature factors may affect toxicity. (cdc.gov)
  • Amphetamine is also the parent compound of its own structural class, the substituted amphetamines , [note 4] which includes prominent substances such as bupropion , cathinone , MDMA (ecstasy) , and methamphetamine . (wikidoc.org)
  • After World War II, civilian use of amphetamines increased, and another form of the drug, methamphetamine- easily produced in small domestic labs-also hit the market. (narconon.org)
  • Those abusing any drug, but amphetamine or methamphetamine in particular, are likely to be severely deficient in usual nutrients. (narconon.org)
  • Common amphetamines found in products that contain Adderall/amphetamines besides amphetamine and metamphetamine are going to have any modifications of it, such as 4-Fluoroamphetamine , or propylhexedrine (Hexahydro-methamphetamine), phentermine (a-methyl-amphetamine), and then compounds like methylphenidate which work via dopamine reuptake inhibition rather than forced release. (sfweekly.com)
  • Amphetamine and methamphetamine inhalers regarded as prescription drugs. (cornell.edu)
  • From complaints by law-enforcement officials, health officials, individual physicians, parents, and others as well as from Food and Drug Administration investigations, it is evident that the wicks from these inhalers are being removed and the methamphetamine they contain is being used as a substitute for amphetamine tablets. (cornell.edu)
  • b) It is the considered opinion of the Food and Drug Administration that, in order to adequately protect the public health, inhalers containing methamphetamine or methamphetamine salts (d-desoxyephedrine, or dl-desoxyephedrine, or their salts), as well as amphetamine inhalers should be restricted to prescription sale and should be labeled with the statement "Rx only. (cornell.edu)
  • Amphetamine also refers to methamphetamine, a chemically-related drug. (addictiongroup.org)
  • Because "at this time, the most effective treatments for methamphetamine addiction [or addiction to other types of amphetamines] are behavioral interventions," this should be a key part of your treatment program (NIDA Archives). (amphetamine.com)
  • However, it can be expected that at such a young age, children will quickly develop a dependence on these drugs, setting the state for addiction to other amphetamines later in life including methamphetamine . (dcclothesline.com)
  • That is exactly what happens to a lot of people who use amphetamines, methamphetamine. (dcclothesline.com)
  • Amphetamine-type stimulants (ATS) such as "ecstasy" and methamphetamine now rank as Africa's second most widely abused drug type. (who.int)
Stimulants11
  • Amphetamine is in a class of medications called central nervous system stimulants. (medlineplus.gov)
  • Amphetamines are central nervous system stimulants that can induce hyperthermia independently or in combination with other risk factors ( 2 ). (cdc.gov)
  • ABSTRACT Amphetamine-type stimulants (ATS) are the second most commonly used illicit drugs in the world, after cannabis. (who.int)
  • La présente étude a pour objectif d'évaluer la situation de la consommation de stimulants de type amphétamines en République islamique d'Iran. (who.int)
  • Les résultats indiquent que la consommation auto-déclarée de methamphétamine et d'ectasie en 2016 était inférieure à 1 % dans la population générale et parmi les étudiants en universités et les élèves du secondaire, mais que la prévalence des stimulants de type amphétamines était plus élevée parmi certains groupes. (who.int)
  • Amphetamines are very addictive stimulants. (kidshealth.org)
  • The term " amphetamine-type stimulants " refers to substances that are chemically similar to amphetamines. (addictiongroup.org)
  • This suggests that drinking moderate levels of alcohol could increase one's vulnerability to the effects of stimulants such as amphetamine. (elementsbehavioralhealth.com)
  • Amphetamine-type stimulants : a global view. (who.int)
  • As cravings for amphetamines and other stimulants can sometimes linger more than any other drug, it may be a good idea to consider a long-term treatment plan. (amphetamine.com)
  • Several stimulants that contain amphetamine are among the most commonly abused stimulants. (orlandorecovery.com)
Adderall9
  • The dose of Adderall(XR) (dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine aspartate monohydrate, amphetamine sulfate) needed to produce toxicity and psychiatric symptoms in a child is as low as 2 mg. (medscape.com)
  • Drugs containing amphetamine, such as Adderall, can suppress your appetite and cause your body to burn up calories at a higher rate than normal. (webmd.com)
  • Currently, pharmaceutical amphetamine is typically prescribed as Adderall , [note 3] dextroamphetamine, or the inactive prodrug lisdexamfetamine . (wikidoc.org)
  • Gentech Addtabz reviews: Is this Ampheta-CDP choline supplement the closest legal Adderall, amphetamine substitute? (sfweekly.com)
  • ADDTabz is advertised as a sophisticated nootropic supplement and a legal replacement for Adderall, a prescription medicine which is an amphetamine used to assist focus in individuals identified as having attention deficit hyperactivity disorder (ADHD). (sfweekly.com)
  • The claimed benefits of this product are improved attentiveness & learning, more focus, and increased energy levels associated with typical amphetamine products, phenylethylamine or other supplements with Adderall. (sfweekly.com)
  • In a far beyond sick release of information, it has been revealed that toddlers can be prescribed amphetamines including, Ritalin, Adderall, and ' ADHD medications ' legally. (dcclothesline.com)
  • Adderall is a combination of dextroamphetamine and amphetamine used primarily to treat ADHD. (orlandorecovery.com)
  • The active ingredients in authentic Adderall tablets are dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate and amphetamine sulfate. (cnn.com)
Central nervous system s2
  • An amphetamine is a central nervous system stimulant that increases certain types of brain activity. (webmd.com)
  • Amphetamine is a potent central nervous system stimulant used in the treatment of attention deficit hyperactivity disorder and narcolepsy . (wikidoc.org)
Positive for amphetamines4
  • To identify additional cases of severe hyperthermia in which workers tested positive for amphetamines, and to support OSHA's enforcement activities, OOMN reviewed all medical records and investigation materials submitted by other OSHA offices to OOMN during January 1, 2010-August 31, 2019. (cdc.gov)
  • I couldn't find any information to confirm that meclizine can cause false positive for amphetamines . (drugs.com)
  • On a drug urine test will Vyvanse show positive for amphetamines? (drugs.com)
  • They were penalized Tuesday under the minor league drug program after testing positive for amphetamines. (washingtontimes.com)
Salts4
  • Formulations of mixed amphetamine salts (e.g. (drugabuse.gov)
  • Dr. Frances R. Levin and Dr. John Grabowski and researchers from the New York State Psychiatric Institute (NYSPI), Columbia University, and the University of Minnesota (UM) hypothesized that mixed amphetamine salts would alleviate ADHD and CUD in patients with both disorders. (drugabuse.gov)
  • The patients received an extended-release formulation of mixed amphetamine salts, in starting doses of 80 milligrams per day or 60 milligrams per day, or a placebo. (drugabuse.gov)
  • Mixed amphetamine salts - is a 3 to 1 combination of d-amphetamine and l-amphetamine. (addictiongroup.org)
Dopamine10
  • Amphetamines also cause the brain to release dopamine. (limamemorial.org)
  • Amphetamine, through activation of a trace amine receptor , increases biogenic amine and excitatory neurotransmitter activity in the brain, with its most pronounced effects targeting the catecholamine neurotransmitters norepinephrine and dopamine. (wikidoc.org)
  • Repeated intermittent exposure to amphetamine produces long-term enhancements in the ability of this drug to produce locomotion and increase extracellular dopamine (DA) in the nucleus accumbens (NAcc). (jneurosci.org)
  • First, the amphetamines compete with cocaine for access to receptors for neurotransmitters, which might prevent cocaine from triggering the massive dopamine release that makes users feel high. (drugabuse.gov)
  • In the first set of experiments, all types of AIMs (axial, limb, orolingual and locomotor) were markedly reduced when amphetamine was co-administered with either the D(2) dopamine receptor antagonist raclopride or the D(1) receptor antagonist SCH23390. (unboundmedicine.com)
  • Our results suggest that amphetamine-induced AIMs in grafted animals primarily depend on an activation of dopamine receptors, and that serotonin neurons within either the grafts or the host brain play a negligible role. (unboundmedicine.com)
  • Relationship between asymmetries in striatal dopamine release and the direction of amphetamine-induced rotation during. (umich.edu)
  • Amphetamine increases dopamine, the brain's reward chemical. (addictiongroup.org)
  • Models of dopamine function based on the bidirectional neuromodulation of afferents [40, 95] were tested by determining whether cortical ablation would affect the excitatory and inhibitory effects of amphetamine (AMPH) on striatal neurons in freely moving rats. (usu.edu)
  • Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. (bvsalud.org)
Addictive3
  • Furthermore, amphetamines can be psychologically but not physically addictive. (medscape.com)
  • Speed, meth, amphetamines, Ecstasy are highly addictive and quite simply very bad for human and animal consumption. (vistataos.com)
  • Researchers soon recognized the addictive properties of amphetamines during the middle of the past century. (addictiongroup.org)
ADHD13
  • Prescription amphetamines are used frequently in children and adolescents to treat attention deficit hyperactivity disorder (ADHD), and they are the most commonly prescribed medications in children. (medscape.com)
  • In adults, narcolepsy, ADHD of the adult type, and some depression can be treated with amphetamines. (medscape.com)
  • Amphetamines can be used to treat medical conditions such as ADHD, but is also taken recreationally, sometimes under the name "speed. (courthousenews.com)
  • Recently the neurotoxic potential of the SAs is a focus because of the popularity of MDMA within the Rave dance culture and interest in its use as a psychotherapy adjunct as well as treatment of ADHD with amphetamine. (cdc.gov)
  • Amphetamine is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy , and is sometimes prescribed off-label for its past medical indications , such as depression , obesity , and nasal congestion . (wikidoc.org)
  • Amphetamine-Based Medication Reduces Cocaine Use in Patients With Both ADHD and CUD Patients receiving 80 milligrams of slow-release mixed amphetamines were less likely to produce cocaine-positive urine samples during the 13-week study than patients receiving 60 milligrams a day, who were less likely than patients receiving placebo. (drugabuse.gov)
  • So we shouldn't have been surprised to wake up January 15 to a media fanfare about the "promise" shown by a new treatment for binge eating disorder - Vyvanse or lis-dex-amphetamine, already marketed for ADHD. (rxisk.org)
  • D-amphetamine - stimulates the Central Nervous System (CNS) to treat ADHD and narcolepsy. (addictiongroup.org)
  • Prescription use of amphetamines to treat ADHD or narcolepsy involves only low doses. (addictiongroup.org)
  • About 10,000 toddlers are now known to be on amphetamines/Ritalin/other ADHD drugs . (dcclothesline.com)
  • When used as prescribed, amphetamines can be a helpful medication for certain conditions , including ADHD, narcolepsy and Parkinson's disease. (orlandorecovery.com)
  • It's chemically similar to amphetamines, a stimulant used to treat ADHD and as a study aid to stay awake. (webmd.com)
  • As the average THCB reader is probably all too well aware I live in Marin County, California and therefore my kids are on amphetamine-based medication for ADHD. (thehealthcareblog.com)
Stop taking amphe1
  • Even after users stop taking amphetamines, they may still have problems such as aggression, anxiety, and strong cravings for the drugs. (kidshealth.org)
Drugs8
  • Amphetamines are drugs. (limamemorial.org)
  • The United Nations Office on Drugs and Crime (UNODC) previously said "reports of amphetamine seizures from countries in the Middle East continue to refer predominantly to tablets bearing the Captagon logo. (cnn.com)
  • No matter how a person takes amphetamines, these drugs hit with a fast high, making the user feel powerful, alert, and energized. (kidshealth.org)
  • Amphetamine is a recreational drugs abused by adults and youngsters in our society for its instant kick. (personalabs.com)
  • Amphetamines are a class of synthetic drugs that have stimulant properties. (addictiongroup.org)
  • Stimulant drugs such as amphetamines are widely abused by young adults who are looking to stay awake and increase their concentration. (elementsbehavioralhealth.com)
  • Mark T. Fillmore, a professor of psychology at the University of Kentucky, said that researchers need to determine whether drinking heavily might produce a physiological change that causes people to be more sensitive to the rewarding effects of drugs like amphetamines. (elementsbehavioralhealth.com)
  • Amphetamine withdrawal symptoms can be uncomfortable and sometimes dangerous, which can encourage someone to start using the drugs again. (orlandorecovery.com)
Attention deficit1
  • Two cases involved legal use of prescription amphetamines to treat attention deficit hyperactivity disorder, and both persons who used legal prescription amphetamines died. (cdc.gov)
Rats7
  • Two decades later, the question came full circle when Science published the results of a complex, placebo-controlled study demonstrating that rats with brain injuries who were given amphetamines in conjunction with physical therapy showed notable improvement in motor function. (news-medical.net)
  • The present study sought to determine the effect of withdrawal from an escalating dose schedule of d-amphetamine on sexual behavior in male rats. (amphetamines.com)
  • Half of the male rats were then subjected to a 4-day escalating dose schedule of d-amphetamine administration (1-12 mg/kg), while half received vehicle. (amphetamines.com)
  • A new study published in the journal Neuroscience finds that rats given regular doses of amphetamines during adolescence have brain and behavioral changes in adulthood. (madinamerica.com)
  • Rats were preexposed to amphetamine, alone or with a DA receptor antagonist, and tested for sensitization 1-3 weeks after the last drug injection. (jneurosci.org)
  • As expected, following intrastriatal transplantation of embryonic ventral mesencephalon all the transplanted rats exhibited pronounced contralateral rotation in response to amphetamine and some animals also showed severe abnormal involuntary movements (AIMs). (unboundmedicine.com)
  • In the second experiment, grafted rats exhibiting amphetamine-induced dyskinesia were subjected to 5,7-dihydroxytryptamine injections into the midbrain in order to destroy the host serotonin innervation. (unboundmedicine.com)
Response to amphetamine1
  • Three experiments were conducted to evaluate the role played by D1 DA receptors in the production of these changes in response to amphetamine. (jneurosci.org)
Effects of Amphetamines2
  • Craig R. Rush, senior author of the study and Professor of Behavioral Science, Psychiatry and Psychology at the University of Kentucky, and his colleagues wanted to build on previous research that showed that moderate drinkers were more sensitive to some of the effects of amphetamines than light drinkers. (elementsbehavioralhealth.com)
  • More research is needed to examine the underlying mechanisms involved with stimulant abuse and alcohol consumption, but one possible explanation is that the moderate drinkers may have been sensitized to the rewarding effects of amphetamines because of increased drug use. (elementsbehavioralhealth.com)
Cocaine and amphetamines1
  • The effect of cocaine and amphetamines on vital signs in trauma patients. (medscape.com)
Contain amphetamine1
  • The counterfeit Captagon tablets contain amphetamine as well as other chemicals, according to the UNODC. (cnn.com)
Street amphetamines1
American Addiction Centers1
  • According to American Addiction Centers, swallowing amphetamine pills can cause a mild high. (webmd.com)
Doses3
  • Much larger doses of amphetamine are likely to impair cognitive function and induce rapid muscle breakdown. (wikidoc.org)
  • Individuals who use amphetamines for recreational purposes tend to take much higher doses. (addictiongroup.org)
  • Over four studies, participants were given a placebo as well as both low and high doses of amphetamine. (elementsbehavioralhealth.com)
Narcolepsy2
  • Amphetamine (Evekeo, others) is also used to treat narcolepsy (a sleep disorder that causes excessive daytime sleepiness and sudden attacks of sleep). (medlineplus.gov)
  • Amphetamine is a strong stimulant that has been used medically for situations when a person needs to be more alert, as in narcolepsy, a health problem that causes a person to fall asleep at any time. (narconon.org)
Abuse8
  • According to a 2020 study published in Molecular Psychiatry , long-term amphetamine abuse can impair short- and long-term memory. (webmd.com)
  • The American Association for Marriage and Family Therapy notes that substance abuse, including amphetamine addiction, can have serious negative consequences on your relationships. (webmd.com)
  • Drug addiction is a serious risk of amphetamine abuse, but only rarely arises from medical use. (wikidoc.org)
  • Over the past six months the abuse of yet another type of amphetamine has come to our attention. (erowid.org)
  • It first appeared in The Speed Culture , his excellent 1975 book on the use and abuse of amphetamines. (rxisk.org)
  • Previous studies have found an association between amphetamine abuse and the amount of alcohol consumed. (elementsbehavioralhealth.com)
  • For example, amphetamine abuse often results in seizures and heart problems. (interventionservicesinc.com)
  • Amphetamine is also a drug of abuse and a psychotomimetic. (bvsalud.org)
Disorders6
  • Either prescription or illegally manufactured amphetamines can induce these disorders. (medscape.com)
  • Amphetamine-related psychiatric disorders are conditions resulting from intoxication or long-term use of amphetamines or amphetamine derivatives. (medscape.com)
  • Such disorders can also be experienced during the withdrawal period from amphetamines. (medscape.com)
  • Amphetamine use may elicit or be associated with the recurrence of other psychiatric disorders. (medscape.com)
  • The symptoms of amphetamine-induced psychiatric disorders can be differentiated from those of related primary psychiatric disorders by time. (medscape.com)
  • Amphetamine use disorders can be challenging to overcome, and the first days and weeks of recovery often involve substantial temptation and a high risk for relapse. (orlandorecovery.com)
Ritalin1
  • I've just found a fascinating article in the American Journal of Public Health on 'America's First Amphetamine Epidemic' and how it compares to the current boom in meth and Ritalin use. (mindhacks.com)
Prescription9
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amphetamine and each time you refill your prescription. (medlineplus.gov)
  • In that case, a coworker later alleged to OSHA that before the shift started, the supervisor had provided pills whose appearance was consistent with those of a prescription amphetamine. (cdc.gov)
  • Amphetamines are illegal when they are used without a prescription to get high or improve performance. (limamemorial.org)
  • You usually do not get addicted to prescription amphetamines when you take them at the right dosage to treat your health condition. (limamemorial.org)
  • It is a prescription medication in many countries, and unauthorized possession and distribution of amphetamine is often tightly controlled due to the significant health risks associated with uncontrolled or heavy use. (wikidoc.org)
  • Addtabz's official website states there is no prescription required, however it also says the formulation contains synthetic amphetamines. (sfweekly.com)
  • Amphetamine tablets and amphetamine inhalers have been restricted to prescription sale because of their potentiality for harm to the user. (cornell.edu)
  • In 2018, 1.8% of individuals over the age of 12 had misused prescription amphetamines during the previous 12 months. (addictiongroup.org)
  • The American Academy of Pediatrics doesn't even have guidelines for amphetamine prescription for children below 4 years old. (dcclothesline.com)
Addiction treatment4
  • For those seeking addiction treatment for themselves or a loved one, the Amphetamines.com is a private and convenient solution. (amphetamines.com)
  • Because the physical withdrawal symptoms aren't typically obvious (like those caused by heroin), a person can sometimes detox from amphetamines in an outpatient program and attend addiction treatment in a similar facility. (amphetamine.com)
  • Patients who are not being treated with behavioral therapy for amphetamine addiction are not receiving the full benefits of formal addiction treatment. (amphetamine.com)
  • If you or a loved one is experiencing signs of amphetamine addiction, treatment may be necessary. (orlandorecovery.com)
Medication2
  • If you take too much amphetamine, you may continue to feel a need to take large amounts of the medication, and you may experience unusual changes in your behavior. (medlineplus.gov)
  • Do not stop taking amphetamine without talking to your doctor, especially if you have overused the medication. (medlineplus.gov)
Inhalers1
  • The first pharmaceutical amphetamine was Benzedrine , a brand of inhalers used to treat a variety of conditions. (wikidoc.org)
Synthesized in 18871
  • Amphetamines were first synthesized in 1887 by Romanian chemist Lazar Edeleanu, but it wasn't until the late 1920's that amphetamines were identified as a medically useful mood and energy booster. (news-medical.net)
Chemically related1
  • As a member of the phenethylamine class, amphetamine is also chemically related to the naturally occurring trace amine neuromodulators, specifically phenethylamine [note 5] and N -methylphenethylamine , both of which are produced within the human body. (wikidoc.org)
Uppers1
  • Listen Free to Amphetamines and Other Uppers by Linda Bayer with a Free Trial. (audiobooks.com)
Intoxication5
  • Patients with amphetamine intoxication who present with no life-threatening signs or symptoms may be treated with sedation and observation and may require no laboratory workup. (medscape.com)
  • Patients who are demonstrating only mild symptoms from amphetamine intoxication often respond to sedation and recover rapidly under observation. (medscape.com)
  • Amphetamine or cocaine intoxication is a topic covered in the Diagnosaurus . (unboundmedicine.com)
  • Zeiger, Roni F.. "Amphetamine or Cocaine Intoxication. (unboundmedicine.com)
  • Emergency Central , emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114915/all/Amphetamine_or_cocaine_intoxication. (unboundmedicine.com)
Serotonin release1
  • I found some referenced literature on Wiki indicating serotonin release is a property of d-amphetamine. (dr-bob.org)
Locomotor5
  • On the test for sensitization, locomotor (experiments 1 and 2) and NAcc DA (experiment 3) responses of the animals to a systemic amphetamine injection were assessed. (jneurosci.org)
  • In the first experiment, systemic injections of the D1 DA receptor antagonist SCH23390, but not other DA receptor antagonists with greater affinity for D2 DA and 5-HT2 receptors, blocked the development of locomotor sensitization produced by systemic injections of amphetamine. (jneurosci.org)
  • In the second experiment, locomotor sensitization induced by infusion of amphetamine into the ventral tegmental area (VTA) was blocked when these injections were preceded by systemic injections of SCH23390. (jneurosci.org)
  • These results indicate that while D2 DA receptor activation is not necessary for the induction of locomotor sensitization to amphetamine, D1 DA receptors located in the VTA play a critical role in the development of sensitized locomotor and NAcc DA response to this drug. (jneurosci.org)
  • Cotreatment with the 5-HT(1A) agonist 8-OH-DPAT significantly attenuated the amphetamine-induced axial and limb dyskinesias, whilst locomotor scores remained unchanged. (unboundmedicine.com)
Derivatives1
  • Methyl derivatives come from theme and variation of the molecular compound of amphetamine, adding hydrogen and carbon molecules on a skeletal structure to create slightly different forms of speed. (vistataos.com)
Markedly reduced1
  • On decreased PIP2 availability, amphetamine-evoked currents were markedly reduced compared with controls, as was amphetamine-induced efflux. (uab.edu)
Pleasurable effects1
Pills4
  • Some 47 million amphetamine pills hidden in a flour shipment were seized by Saudi Arabia's authorities. (cnn.com)
  • Authorities in Saudi Arabia have confiscated 47 million amphetamine pills which were hidden in a flour shipment, in an operation described as the biggest one-time drug smuggling attempt in terms of narcotics seized. (cnn.com)
  • The story below, a first-person account of life on (and off) amphetamine "diet pills," was written over forty years ago. (rxisk.org)
  • None of the admiring media accounts used the word "amphetamine", let alone "speed" or Pep Pills. (rxisk.org)
Substance1
  • Nine (26.5%) of these 34 workers tested positive for an amphetamine-class substance. (cdc.gov)
Reptile1
  • I'm half-tempted to start declaring Evenson, and some of the writers who have claimed him as an influence (Blake Butler, Matt Bell, Aaron Burch, etc.), as being of the school of Amphetamine Reptile Lit. (vol1brooklyn.com)
Phenethylamine1
  • If it's not a substituted phenethylamine, it can't be an amphetamine. (sfweekly.com)
Keep-awake utility2
  • Amphetamine is the most powerful and customizable keep-awake utility ever created for macOS. (apple.com)
  • Welcome to Amphetamine, the most awesome keep-awake utility ever created for macOS. (producthunt.com)
Drug8
  • Although researchers could not directly link the spike in drug use to the lockdown, "the fact remains that amphetamine use has been higher than ever before, at least in the Helsinki metropolitan area," said Teemu Gunnar, head of forensic toxicology at the National Institute for Health and Welfare. (courthousenews.com)
  • Some people who abused this drug would wear themselves out with amphetamine binges, taking the drug continuously and, not sleeping or eating for as long as a week. (narconon.org)
  • Long-term amphetamine abusers are likely to be severely malnourished and suffering serious mental effects from the drug use. (narconon.org)
  • When a person chooses a Narconon drug and alcohol rehabilitation center for recovery from amphetamine addiction, the withdrawal process is eased by the program's unique and innovative techniques. (narconon.org)
  • As an aside, when patients complained about the agitation associated with amphetamine treatment, the drug companies brought out new medications which were speed mixed with barbituates, a class of sedatives. (mindhacks.com)
  • Finally, in experiment three, co-injecting SCH23390, but not its inactive enantiomer, with amphetamine into the VTA during preexposure prevented sensitization of the NAcc DA response to this drug. (jneurosci.org)
  • The researchers found that the high dose of amphetamines increased drug use in both light and moderate drinkers, whereas the low dose only increased drug use among the moderate drinkers. (elementsbehavioralhealth.com)
  • Phentermine could raise a false red flag in your drug screen if you don't have a medical reason for taking amphetamines. (webmd.com)
Anxiety1
  • A 2020 study published in Current Topics in Medicinal Chemistry found that anxiety sensitivity was more common in amphetamine users than in those who do not use amphetamines. (webmd.com)
Lockdown1
  • Finns may be known for their love of vodka and beer, but growing numbers in the Nordic nation appear to have turned to amphetamines to cope with the coronavirus lockdown, health officials said on Thursday. (courthousenews.com)
Stay awake1
  • Some people use amphetamines to help them stay awake on the job or to study for a test. (limamemorial.org)
Levoamphetamine1
  • [note 2] Amphetamine properly refers to a specific chemical, the racemic free base , which is equal parts of the two enantiomers, levoamphetamine and dextroamphetamine, in their pure amine forms. (wikidoc.org)
Uptake1
  • These findings demonstrate that PIP 2 binding to monoamine transporters is a prerequisite for amphetamine actions without being a requirement for neurotransmitter uptake. (uab.edu)
Urine test2
  • After taking sudafed why did I have a positive amphetamine urine test? (drugs.com)
  • Is there a otc nasal spray that may show positive results for amphetamines in a urine test? (drugs.com)
Stimulation1
  • And not all amphetamines are good for psychological stimulation. (sfweekly.com)
Disorder2
  • Amphetamine-induced movement disorder. (medscape.com)
  • If symptoms do not resolve within 2 weeks after the amphetamines are discontinued, a primary psychiatric disorder should be suspected. (medscape.com)
Euphoria1
  • The leaves of the tree are chewed, extracting the active ingredient, cathinone, and producing the desired effects of euphoria and, unlike other amphetamines, anesthesia. (medscape.com)
Misuse2
  • Misuse of amphetamines may also involve dissolving the powder in water and injecting it. (webmd.com)
  • People with prolonged amphetamine use or misuse have a strong likelihood of becoming addicted. (orlandorecovery.com)
Striatal1
  • Amphetamine effects on striatal neurons: implications for models of do" by John L. Haracz, JoAnn T. Tschanz et al. (usu.edu)
Psychostimulants1
  • An increase in extracellular serotonin results from transporter-mediated efflux triggered by amphetamine-like psychostimulants. (uab.edu)
Withdrawal symptoms1
  • A person could be suffering and in need of much more help, as amphetamine withdrawal symptoms are usually psychological for the most part. (amphetamine.com)
Browsing by Subject Amphetamine
Browsing by Subject "Amphetamine" (apps.who.int:80)
Parcourir par sujet METHYLENEDIOXY-3,4 AMPHETAMINE
Parcourir par sujet "METHYLENEDIOXY-3,4 AMPHETAMINE" (apps.who.int:80)
Notes from the Field: Amphetamine Use Among Workers with Severe Hyperthermia - Eight States, 2010-2019 | MMWR
Notes from the Field: Amphetamine Use Among Workers with Severe Hyperthermia - Eight States, 2010-2019 | MMWR (cdc.gov)
Browsing Information products by Subject Amphetamine-Related Disorders
Browsing Information products by Subject "Amphetamine-Related Disorders" (apps.who.int)
Attention-Deficit/Hyperactivity Disorder Medication Prescription Claims Among Privately Insured Women Aged 15-44 Years - United...
Attention-Deficit/Hyperactivity Disorder Medication Prescription Claims Among Privately Insured Women Aged 15-44 Years - United... (cdc.gov)
Stimulant Guide | Feature Topics | Drug Overdose
Stimulant Guide | Feature Topics | Drug Overdose (cdc.gov)
Assessment of Neonatal Abstinence Syndrome Surveillance - Pennsylvania, 2019 | MMWR
Assessment of Neonatal Abstinence Syndrome Surveillance - Pennsylvania, 2019 | MMWR (cdc.gov)
Controlled Substance Prescribing Patterns - Prescription Behavior Surveillance System, Eight States, 2013
Controlled Substance Prescribing Patterns - Prescription Behavior Surveillance System, Eight States, 2013 (cdc.gov)
Proton Pump and VEGF Inhibitors Among Adds to FDA Watch List
Proton Pump and VEGF Inhibitors Among Adds to FDA Watch List (medscape.com)
Tardive Dyskinesia: Overview, Pathophysiology, Etiology
Tardive Dyskinesia: Overview, Pathophysiology, Etiology (medscape.com)
Amphetamine: MedlinePlus Drug Information
Amphetamine: MedlinePlus Drug Information (medlineplus.gov)
Changes in Opioid-Involved Overdose Deaths by Opioid Type and Presence of Benzodiazepines, Cocaine, and Methamphetamine - 25...
Changes in Opioid-Involved Overdose Deaths by Opioid Type and Presence of Benzodiazepines, Cocaine, and Methamphetamine - 25... (cdc.gov)
Unstable Angina: Practice Essentials, Background, Pathophysiology
Unstable Angina: Practice Essentials, Background, Pathophysiology (medscape.com)
Methamphetamine overdose: MedlinePlus Medical Encyclopedia
Methamphetamine overdose: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Notes from the Field: Increased Incidence of Fentanyl-Related Deaths Involving Para-fluorofentanyl or Metonitazene - Knox...
Notes from the Field: Increased Incidence of Fentanyl-Related Deaths Involving Para-fluorofentanyl or Metonitazene - Knox... (cdc.gov)
Mental health and psychosocial support platform - substance us
Mental health and psychosocial support platform - substance us (emro.who.int)
Une amphétamine autorisée dans le binge eating aux US
Une amphétamine autorisée dans le binge eating aux US (medscape.com)
Amphetamine Toxicity: Practice Essentials, Pathophysiology, Etiology
Amphetamine Toxicity: Practice Essentials, Pathophysiology, Etiology (medscape.com)
Active Ingredient in OTC Inhaler a 'New' Drug of Abuse
Active Ingredient in OTC Inhaler a 'New' Drug of Abuse (medscape.com)
Astronomical Rise in Amphetamine-Related Hospitalizations, Costs
Astronomical Rise in Amphetamine-Related Hospitalizations, Costs (medscape.com)
DailyMed - AMPHETAMINE SULFATE tablet
DailyMed - AMPHETAMINE SULFATE tablet (dailymed.nlm.nih.gov)