An enzyme that catalyzes the deamination of AMP to IMP. EC 3.5.4.6.
Catalyze the hydrolysis of nucleotides with the elimination of ammonia.
An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.
Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Drugs that inhibit ADENOSINE DEAMINASE activity.
An enzyme that catalyzes the deamination of cytidine, forming uridine. EC 3.5.4.5.
A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
An enzyme which catalyzes the deamination of CYTOSINE resulting in the formation of URACIL. It can also act on 5-methylcytosine to form THYMIDINE.
An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and ammonia. It plays an important role in the regulation of the pool of deoxynucleotides in higher organisms. The enzyme also acts on some 5-substituted deoxycytidylic acids. EC 3.5.4.12.
Catalyze the hydrolysis of nucleosides with the elimination of ammonia.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
An enzyme that catalyzes the deamination of guanine to form xanthine. EC 3.5.4.3.
Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)
The rate dynamics in chemical or physical systems.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Inorganic salts of phosphoric acid.
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Contractile tissue that produces movement in animals.
An enzyme that catalyzes the tetrapolymerization of the monopyrrole PORPHOBILINOGEN into the hydroxymethylbilane preuroporphyrinogen (UROPORPHYRINOGENS) in several discrete steps. It is the third enzyme in the 8-enzyme biosynthetic pathway of HEME. In humans, deficiency in this enzyme encoded by HMBS (or PBGD) gene results in a form of neurological porphyria (PORPHYRIA, ACUTE INTERMITTENT). This enzyme was formerly listed as EC 4.3.1.8
Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.
A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.
Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Relatively complete absence of oxygen in one or more tissues.
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
The dormant state in which some warm-blooded animal species pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs.
A family of the order Rodentia which contains 49 genera. Some of the more common genera are MARMOTA, which includes the marmot and woodchuck; Sciurus, the gray squirrel, S. carolinensis, and the fox squirrel, S. niger; Tamias, the eastern and western chipmunk; and Tamiasciurus, the red squirrel. The flying squirrels, except the scaly-tailed Anomaluridae, also belong to this family.
Cell surface receptors that are specific for INTERLEUKIN-8. Two specific receptor subtypes (type A and B) have been found and bind IL-8 with high affinity.
An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.
A family of anaerobic METHANOSARCINALES whose cells are mesophilic or thermophilic and appear as irregular spheroid bodies or sheathed rods. These methanogens are found in any anaerobic environment including aquatic sediments, anaerobic sewage digesters and gastrointestinal tracts. There are four genera: METHANOSARCINA, Methanolobus, Methanothrix, and Methanococcoides.
Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
Glucose in blood.
Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.
An essential amino acid that is required for the production of HISTAMINE.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Persistence of the nuclei of the keratinocytes into the stratum corneum of the skin. This is a normal state only in the epithelium of true mucous membranes in the mouth and vagina. (Dorland, 27th ed)
The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed)
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.

Regulation of AMP deaminase from chicken erythrocytes. A kinetic study of the allosteric interactions. (1/194)

The allosteric properties of AMP deaminase [EC 3.5.4.6] from chicken erythrocytes have been qualitatively and quantitatively accounted for by the concerted transition theory of Monod et al., on the assumption that this enzyme has different numbers of binding sites for each ligand. Theoretical curves yield a satisfactory fit for all experimental saturation functions with respect to activation by alkali metals and inhibition by Pi, assuming that the numbers of binding sites for AMP, alkali metals, and Pi are 4, 2, and 4, respectively. The enzyme was inhibited by concentrations of ATP and GTP below 0.1 and 0.25 mM, respectively, whereas activation of the enzyme was observed at ATP and GTP concentrations above 0.4 and 1.5 mM, respectively. These unusual kinetics with respect to ATP and GTP could be also accounted for by assuming 2 inhibitory and 4 activating sites for each ligand.  (+info)

Regulation of chicken erythrocyte AMP deaminase by phytic acid. (2/194)

AMP deaminase [EC 3.5.6.4] purified from chicken erythrocytes was inhibited by phytic acid (inositol hexaphosphate), which is the principal organic phosphate in chicken red cells. Kinetic analysis has indicated that this inhibition is of an allosteric type. The estimated Ki value was within the normal range of phytic acid concentration, suggesting that this compound acts as a physiological effector. Divalent cations such as Ca2+ and Mg2+ were shown to affect AMP deaminase by potentiating inhibition by lower concentrations of phytic acid, and by relieving the inhibition at higher concentrations of phytic acid. These results suggests that Ca2+ and Mg2+ can modify the inhibition of AMP deaminase by phytic acid in chicken red cells.  (+info)

Common variant in AMPD1 gene predicts improved clinical outcome in patients with heart failure. (3/194)

BACKGROUND: This study was undertaken to identify gene(s) that may be associated with improved clinical outcome in patients with congestive heart failure (CHF). The adenosine monophosphate deaminase locus (AMPD1) was selected for study. We hypothesized that inheritance of the mutant AMPD1 allele is associated with increased probability of survival without cardiac transplantation in patients with CHF. METHODS AND RESULTS: AMPD1 genotype was determined in 132 patients with advanced CHF and 91 control reference subjects by use of a polymerase chain reaction-based, allele-specific oligonucleotide detection assay. In patients with CHF, those heterozygous (n=20) or homozygous (n=1) for the mutant AMPD1 allele (AMPD1 +/- or -/-, respectively) experienced a significantly longer duration of heart failure symptoms before referral for transplantation evaluation than CHF patients homozygous for the wild-type allele (AMPD1 +/+; n=111; 7.6+/-6.5 versus 3.2+/-3.6 years; P<0.001). The OR of surviving without cardiac transplantation >/=5 years after initial hospitalization for CHF symptoms was 8.6 times greater (95% CI: 3.05, 23.87) in those patients carrying >/=1 mutant AMPD1 allele than in those carrying 2 wild-type AMPD1 +/+ alleles. CONCLUSIONS: After the onset of CHF symptoms, the mutant AMPD1 allele is associated with prolonged probability of survival without cardiac transplantation. The mechanism by which the presence of the mutant AMPD1 allele may modify the clinical phenotype of heart failure remains to be determined.  (+info)

AMP deaminase in piglet cardiac myocytes: effect on nucleotide metabolism during ischemia. (4/194)

The purpose of this study was to examine in situ regulation of AMP deaminase in newborn piglet cardiac myocytes and to determine its role in nucleotide metabolism during ischemia. When a rapid deenergization paradigm was used to assay AMP deaminase, enzyme activity depended on the hormonal and metabolic status of cells just before deenergization. Inosine 5'-monophosphate (IMP) formation was increased 150% in deenergized myocytes pretreated with phorbol 12-myristate 13-acetate (PMA; EC50 = 4.7 x 10(-8) M). This effect was 90% blocked with the protein kinase C (PKC) inhibitor staurosporine. In addition, the beta-adrenergic agonist isoproterenol stimulated AMP deaminase activity (EC50 = 1.5 x 10(-8) M), and IMP formation was directly correlated to intracellular cAMP levels (r2 = 0.9). Furthermore, adenosine increased IMP formation, whereas nonrespiring, glycolyzing piglet myocytes had reduced AMP deaminase activity. Pretreatment of perfused piglet hearts with adenosine, but not PMA, before exposure to global ischemia resulted in enhanced conversion of AMP to IMP during the ischemic period. Similar results were obtained in piglet myocytes preincubated with adenosine or PMA before exposure to simulated ischemia. These results may be relevant to the preconditioning phenomenon.  (+info)

5'-Nucleotidase as a marker of both general and local inflammation in rheumatoid arthritis patients. (5/194)

OBJECTIVES: To evaluate measurements of serum and synovial fluid 5'-nucleotidase (5'N) activity as a marker of general and local inflammation in arthritis, and to resolve a contradiction in the literature as to whether or not the activity of 5'N in the synovial fluids of rheumatoid arthritis (RA) patients is raised in comparison with that in the synovial fluids of other arthritis patients. METHODS: Assays for 5'N were carried out in the presence of inhibitors of other phosphatases, AMP deaminase and of 5'N itself. RESULTS: The 5'N activity in the synovial fluid of RA patients was both significantly higher (mean 1.7-fold) and had a greater variance than that in the synovial fluids of other arthritis patients, and the contradiction in the literature was resolved. There was a strong correlation between the 5'N activity in the sera of RA patients and their erythrocyte sedimentation rate. There was no significant correlation between the 5'N in the serum and synovial fluid for the RA patients, in marked contrast to the strong correlation between the two 5'N activities shown by the osteoarthritis patients. The 5'N activity was greater in the synovial fluid than in the serum for virtually all the patients, showing that it was being made locally. CONCLUSIONS: The 5'N activity in the serum (which came mostly from the liver) could be used as a marker of general inflammation, whereas the 5'N in the synovial fluid was mostly produced locally, and could be used as a marker of joint inflammation, particularly for the RA patients.  (+info)

Regulation of AMP deaminase by phosphoinositides. (6/194)

AMP deaminase (AMPD) converts AMP to IMP and is a diverse and highly regulated enzyme that is a key component of the adenylate catabolic pathway. In this report, we identify the high affinity interaction between AMPD and phosphoinositides as a mechanism for regulation of this enzyme. We demonstrate that endogenous rat brain AMPD and the human AMPD3 recombinant enzymes specifically bind inositide-based affinity probes and to mixed lipid micelles that contain phosphatidylinositol 4,5-bisphosphate. Moreover, we show that phosphoinositides specifically inhibit AMPD catalytic activity. Phosphatidylinositol 4,5-bisphosphate is the most potent inhibitor, effecting pure noncompetitive inhibition of the wild type human AMPD3 recombinant enzyme with a K(i) of 110 nM. AMPD activity can be released from membrane fractions by in vitro treatment with neomycin, a phosphoinositide-binding drug. In addition, in vivo modulation of phosphoinositide levels leads to a change in the soluble and membrane-associated pools of AMPD activity. The predicted human AMPD3 sequence contains pleckstrin homology domains and (R/K)X(n)(R/K)XKK sequences, both of which are characterized phosphoinositide-binding motifs. The interaction between AMPD and phosphoinositides may mediate membrane localization of the enzyme and function to modulate catalytic activity in vivo.  (+info)

Energy metabolism and lipid peroxidation of human erythrocytes as a function of increased oxidative stress. (7/194)

To study the influence of oxidative stress on energy metabolism and lipid peroxidation in erythrocytes, cells were incubated with increasing concentrations (0.5-10 mM) of hydrogen peroxide for 1 h at 37 degrees C and the main substances of energy metabolism (ATP, AMP, GTP and IMP) and one index of lipid peroxidation (malondialdehyde) were determined by HPLC on cell extracts. Using the same incubation conditions, the activity of AMP-deaminase was also determined. Under nonhaemolysing conditions (at up to 4 mM H2O2), oxidative stress produced, starting from 1 mM H2O2, progressive ATP depletion and a net decrease in the intracellular sum of adenine nucleotides (ATP + ADP + AMP), which were not paralleled by AMP formation. Concomitantly, the IMP level increased by up to 20-fold with respect to the value determined in control erythrocytes, when cells were challenged with the highest nonhaemolysing H2O2 concentration (4 mM). Efflux of inosine, hypoxanthine, xanthine and uric acid towards the extracellular medium was observed. The metabolic imbalance of erythrocytes following oxidative stress was due to a dramatic and unexpected activation of AMP-deaminase (a twofold increase of activity with respect to controls) that was already evident at the lowest dose of H2O2 used; this enzymatic activity increased with increasing H2O2 in the medium, and reached its maximum at 4 mM H2O2-treated erythrocytes (10-fold higher activity than controls). Generation of malondialdehyde was strictly related to the dose of H2O2, being detectable at the lowest H2O2 concentration and increasing without appreciable haemolysis up to 4 mM H2O2. Besides demonstrating a close relationship between lipid peroxidation and haemolysis, these data suggest that glycolytic enzymes are moderately affected by oxygen radical action and strongly indicate, in the change of AMP-deaminase activity, a highly sensitive enzymatic site responsible for a profound modification of erythrocyte energy metabolism during oxidative stress.  (+info)

IMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment. (8/194)

We examined gene regulation in murine lungs after hind-limb vessel occlusion and reperfusion. A rapid increase of transcript for the AMP deaminase 3 gene (AMPD3) and its enzymatic activity (EC) generating inosine monophosphate (IMP) were identified with transcripts located in bronchial and alveolar epithelium. AMP deaminase inhibitor decreased IMP levels and significantly enhanced neutrophil recruitment within lung tissue during reperfusion. In addition, IMP inhibited cytokine-initiated neutrophil infiltration in vivo and selectively attenuated neutrophil rolling by 90% in microvessels. We prepared labeled IMP and demonstrated that IMP specifically binds to neutrophils. IMP also stimulated binding of gamma-[(35)S]thio-GTP, suggesting that IMP is a potent regulator of neutrophils. Taken together, these results elucidate a previously unrecognized mechanism that protects tissues from the potentially deleterious consequences of aberrant neutrophil accumulation. Moreover, they are relevant for new therapeutic approaches to regulate neutrophil responses in inflammation and vascular disease.  (+info)

AMPD2; adenosine monophosphate deaminase 2; adenosine monophosphate deaminase 2 (isoform L); AMP deaminase 2; AMPD isoform L; adenosine monophosphate deaminase 2 isoform L; AMP deaminase isoform L; AMPD 2; AMPD2_HUMAN; AMPD ...
Adenosine monophosphate deaminase deficiency type 1, also called myoadenylate deaminase deficiency (MADD), is a recessive genetic metabolic disorder that affects approximately 1-2% of populations of European descent. It appears to be considerably rarer in Asian populations. The genetic form is caused by a defect in the gene for AMP deaminase though there is also an acquired form of AMP deficiency. Although many people with a defective AMPD gene are asymptomatic, others may have symptoms such as exercise intolerance, muscle pain, and muscle cramping. Fatigue MADD lowers aerobic power output, so increased anaerobic power is needed to perform the same amount of work.[citation needed] Without myoadenlyate deaminase, heavy activity causes adenosine to be released into the cell or perfused into the surrounding tissues. Fatigue and sedation after heavy exertion can be caused by excess adenosine in the cells which signals muscle fiber to feel fatigued. In the brain, excess adenosine decreases alertness ...
Reaction of rabbit skeletal-muscle AMP deaminase with a low molar excess of diethyl pyrocarbonate results in conversion of the enzyme into a species with one or two carbethoxylated histidine residues per subunit that retains sensitivity to ATP at pH 7.1 but, unlike the native enzyme, it is not sensitive to regulation by ATP at pH 6.5. This effect mimics that exerted on the enzyme by limited proteolysis with trypsin, which removes the 95-residue N-terminal region from the 80 kDa enzyme subunit. These observations suggest involvement of some histidine residues localized in the region HHEMQAHILH (residues 51-60) in the regulatory mechanism which stabilizes the binding of ATP to its inhibitory site at acidic pH. Carbethoxylation of two histidine residues per subunit abolishes the inhibition by ATP of the proteolysed enzyme at pH 7.1, suggesting the obligatory participation of a second class of histidine residues, localized in the 70 kDa subunit core, in the mechanism of the pH-dependent inhibition ...
A major finding in the current study was the ability of the muscle to maintain TCA cycle intermediate (TCAi) concentrations and cellular energy charge during exercise in spite of AMPD activity being less than 1 % of control values. This finding demonstrates the utility of using an inborn error of metabolism to unravel a fundamental question in muscle physiology, namely, that the PNC is not required for TCA cycle anaplerosis. From a clinical perspective, the main finding in this study is that patients with less than 1 % residual AMPD activity were not markedly different from subjects with normal AMPD activity in their tolerance for progressive cycle ergometry exercise.. One conceivable consequence of AMPD deficiency would be an impairment of the PNC with a resultant attenuation of TCAi anaplerosis (Sabina et al. 1980; Flanagan et al. 1986). It has previously been demonstrated that the total muscle TCAi content increased severalfold during the initial minutes of moderate to intense contraction, ...
Fluorescent antibody staining experiments with both isolated myofibrils and muscle fibers grown in culture show that AMP deaminase is bound to the myofibril in the A band. The strongest staining occurs at each end of the A band. The approximate width of the fluorescent stripes and their relation to the A band remains constant as a function of sarcomere length. Removal of enzyme from the myofibrils leads to loss of staining, and readdition of purified enzyme restores the original staining pattern. A histoenzymatic method for the detection of AMP deaminase activity in cultured fibers gives comparable localization. The results are consistent with the previous observation (Ashby, B. and C. Frieden. 1977.J. Biol. Chem. 252:1869--1872) that AMP deaminase forms a tight complex in solution with subfragment-2 (S-2) of myosin or with heavy meromyosin (HMM). ...
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Studies on the effect of genetic polymorphisms known to affect AMP deaminase (AMPD) activity on progress of heart disease are conflicting: some highlights benefit of decreased AMPD activity in heart failure and ischemic heart disease while the other failed to confirm it. Detailed studies to identify clinical scenario that benefits from decreased AMPD activity are thus needed. We evaluated cardiac effects of decreased AMPD activity during acute oxygen deprivation in clinical and experimental settings. Patients undergoing coronary artery bypass grafting with use of extracorporeal circulation (n=184) were clinically analyzed and genotyped for C34T mutation of AMPD1 that we previously found to decrease cardiac AMPD activity. The effect of new inhibitor of AMPD: 3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol (AMPDI) was tested in apoA/LDLr knockout mouse exposed for 5 min to 5% oxygen in breathing air. The activity of AMP regulated protein ...
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TY - JOUR. T1 - AMP deaminase and thymidine kinase deficiencies in a mutant mouse S49 cell clone.. AU - Hanson, S.. AU - Ullman, B.. N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. PY - 1989. Y1 - 1989. N2 - From a mutagenized population of wild type S49 cells, a clone was isolated in a single step that possessed functional and biochemical deficiencies in both AMP deaminase and thymidine kinase activities. This mutant cell line, DTB6, was selected in semi-solid medium containing 1mM thymidine and 1mM dibutyryl cyclic AMP. In comparative growth rate experiments, DTB6 cells were considerably less sensitive than parental cells to the growth inhibitory effects of thymidine. In contrast, DTB6 cells were much more sensitive to the cytotoxic effects of adenine and adenosine. The supersensitivity of DTB6 cells toward adenine could be ameliorated by the addition of hypoxanthine to the culture medium. The growth phenotype of the mutant cells ...
Creatine Phosphokinase Increased & Inability to Supinate Forearm & Joint Hypermobility Symptom Checker: Possible causes include Myoadenylate Deaminase Deficiency. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Hibernating animals develop fatty liver when active in summertime and undergo a switch to a fat oxidation state in the winter. We hypothesized that this switch might be determined by AMP and the dominance of opposing effects: metabolism through AMP deaminase (AMPD2) (summer) and activation of AMP-activated protein kinase (AMPK) (winter). Liver samples were obtained from 13-lined ground squirrels at different times during the year, including summer and multiples stages of winter hibernation, and fat synthesis and β-fatty acid oxidation were evaluated. Changes in fat metabolism were correlated with changes in AMPD2 activity and intrahepatic uric acid (downstream product of AMPD2), as well as changes in AMPK and intrahepatic β-hydroxybutyrate (a marker of fat oxidation). Hepatic fat accumulation occurred during the summer with relatively increased enzymes associated with fat synthesis (FAS, ACL and ACC) and decreased enoyl CoA hydratase (ECH1) and carnitine palmitoyltransferase 1A (CPT1A), rate limiting
Complete information for AMPD3 gene (Protein Coding), Adenosine Monophosphate Deaminase 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for AMPD1 gene (Protein Coding), Adenosine Monophosphate Deaminase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Tracy, Saoirse and Gómez, José Fernández and Sturrock, Craig and Wilson, Zoe A. and Ferguson, Alison (2017) Non-destructive determination of floral staging in cereals using X-ray micro computed tomography (µCT). Plant Methods, 13 (9). ISSN 1746-4811 Ferguson, Alison and Pearce, Simon and Band, Leah R. and Yang, Caiyun and Ferjentsikova, Ivana and King, John and Yuan, Zheng and Zhang, Dabing and Wilson, Zoe A. (2016) Biphasic regulation of the transcription factor ABORTED MICROSPORES (AMS) is essential for tapetum and pollen development in Arabidopsis. New Phytologist, 213 . pp. 778-790. ISSN 1469-8137 Chew, Bee Lynn and Fisk, Ian D. and Fray, Rupert and Tucker, Gregory A. and Bodi, Zsuzsanna and Ferguson, Alison and Xiao, Wei and Seymour, Graham B. (2016) The effect of adenosine monophosphate deaminase overexpression on the accumulation of umami-related metabolites in tomatoes. Plant Cell Reports, 36 (1). pp. 81-87. ISSN 1432-203X Pearce, Simon and Ferguson, Alison and King, John and Wilson, ...
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Learn more about Ribose at Sky Ridge Medical Center Uses Principal Proposed Uses None Other Proposed Uses AMPD (Congenital Myoadenylate Deaminase...
Learn more about Ribose at Medical City Dallas Uses Principal Proposed Uses None Other Proposed Uses AMPD (Congenital Myoadenylate Deaminase...
Given that aldolase B is Commonly current in kidney and intestinal mucosa and in liver, Cox et al. (1982) ended up ready to detect heterozygotes by intestinal biopsy. In a Jewish relatives, they shown that evident dominant inheritance was the result of a homozygote-heterozygote mating. Diagnosis In aldolase B-deficient tissues, cytoplasmic accumulation of fructose-1-phosphate causes sequestration of inorganic phosphate with ensuing activation of AMP deaminase that catalyzes the irreversible deamination of AMP to IMP (inosine monophosphate), a precursor of uric acid. During the cytoplasm, AMP, ADP, and ATP are managed inside a point out approaching equilibrium. Depletion of tissue ATP takes place by means of large degradation to uric acid and impairment of regeneration by oxidative phosphorylation while in the mitochondria on account of inorganic phosphate depletion ...
ID TRBRU1_8_PE727 STANDARD; PRT; 1417 AA. AC TRBRU1_8_PE727; Q38E23; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE SubName: Full=AMP deaminase, putative; (TRBRU1_8.PE727). GN ORFNames=Tb09.211.1320; OS TRYPANOSOMA BRUCEI TREU927. OC Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma. OX NCBI_TaxID=185431; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS TRBRU1_8.PE727. CC Trypanosoma brucei TREU927 chromosome 9, complete sequence. CC sequence. CC -!- ANNOTATIONS ORIGIN:Q38E23_9TRYP CC -!- GENE_FAMILY: HOG000260943 [ FAMILY / ALN / TREE ] DR UniProtKB/Swiss-Prot; Q38E23; -. DR EMBL; CM000207; EAN76947.1; -; Genomic_DNA. DR RefSeq; XP_827277.1; XM_822184.1. DR ProteinModelPortal; Q38E23; -. DR STRING; Q38E23; -. DR GeneID; 3660666; -. DR KEGG; tbr:Tb09.211.1320; -. DR EuPathDB; EupathDB:Tb09.211.1320; -. DR eggNOG; KOG1096; -. DR ProtClustDB; PTZ00310; -. DR GO; ...
Description This activity is closed to further registration. Come and learn soul line-dancing to the music of Motown, R&B and Jazz; it will work out the ...
Muscle & Strength explains that most weight training experts do not recommend working out the same muscle group more than once per training session. Overworking the muscles leads to severe muscle...
Why Elite Ion-Power? Supports rapid hydration Bio-available and instantly absorbed Supports body water balance Supports body temperature Supports muscles & nerves Naturally sourced Sugar, carbohydrate and excipient free Economical and convenient to use No mould or residue in your hydration pack Suitable for all age
I have a pair of speakers 8ohm 40W ceiling speakers connected to a amp. The amps has a 3.5mm jack input which ive got a IP telephone plugged into using a...
Human HRG/HPRG HEK293 Overexpression Lysate | SinoBiological, 10836-H08HL is used as western blot (WB) positive control. Bulk order, Produced in house, High quality guarrantee.
This strapless bandeau top WENDY has soft side boning and a subtle gather to ensure comfortable support. The tie back looks gorgeous in a bow, perfect to get on and off with ease. Our custom metal trident clip, slides on & off giving the option to wear cinched in the centre front or not. The trident is a sacred sym
The reconstituted glycolytic system described previously (Scopes, 1973) was used to simulate post-mortem glycolytic metabolism in muscle. The effects of the following factors have been investigated: ATPase (adenosine triphosphatase) amount, AMP deaminase amount, percentage of the phosphorylase in the a form and the effect of diluting the glycolytic enzyme complex as a whole. It was confirmed that the rate of metabolism was solely dependent on the amount of ATPase present and that various concentrations of the glycolytic enzymes had no effect over a wide range encompassing the variation found in anatomically different muscles. The extent of metabolism, represented by the value of the ultimate pH, depended markedly on the amount of phosphorylase in the a form; as little as 1% of the a form resulted in a considerably lower pH than in its absence. To a lesser extent the amount of AMP deaminase also affected the ultimate pH, but this was probably only significant for comparisons of genetically ...
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IMP→AMP:. *Adenylosuccinate synthase. *Adenylosuccinate lyase. *reverse *AMP deaminase. IMP→GMP:. *IMP dehydrogenase ...
XMP is then converted into GMP by using the hydrolysis of 1 ATP and the conversion of glutamine to glutamate.[1] AMP and GMP ... Guanine is then deaminated via guanine deaminase to form xanthine which is then converted to uric acid. Oxygen is the final ... While IMP can be directly converted to AMP, synthesis of GMP (guanosine monophosphate) requires an intermediate step, in which ... The nucleoside, adenosine, is then deaminated and hydrolyzed to form hypoxanthine via adenosine deaminase and nucleosidase ...
The nucleosides cytidine and deoxycytidine can be salvaged along the uracil pathway by cytidine deaminase, which converts them ... AMP Folate biosynthesis[edit]. Tetrahydrofolic acid and its derivatives are produced by salvage pathways from GTP.[1] ...
AMP deaminase 3 is an enzyme that in humans is encoded by the AMPD3 gene. This gene encodes a member of the AMP deaminase gene ... Mahnke-Zizelman DK, Sabina RL (October 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene ... Ogasawara N, Goto H, Yamada Y, Nishigaki I, Itoh T, Hasegawa I, Park KS (January 1987). "Deficiency of AMP deaminase in ... Yamada Y, Goto H, Wakamatsu N, Ogasawara N (2001). "A rare case of complete human erythrocyte AMP deaminase deficiency due to ...
1998). "Control of AMP deaminase 1 binding to myosin heavy chain". Am. J. Physiol. 275 (3 Pt 1): C870-81. doi:10.1152/ajpcell. ...
It can also be formed by the deamination of adenosine monophosphate by AMP deaminase. It can be hydrolysed to inosine. The ... AMP differs from inosinate by the replacement of IMP's carbon-6 carbonyl with an amino group. The interconversion of AMP and ... Finally, carbon 2 gains the amino group by spending an ATP molecule (which becomes AMP+2Pi). While AMP synthesis requires GTP, ... Within a few steps inosinate becomes AMP or GMP. Both compounds are RNA nucleotides. ...
AMPD2: encoding enzyme AMP deaminase 2. *ARID1A (1p36). *ATXN7L2: Ataxin 7-like 2 ...
... synthase converts IMP to adenylosuccinate adenylosuccinate lyase converts adenylosuccinate into AMP AMP deaminase converts AMP ... then adenosine deaminase creates inosine Alternatively, AMP deaminase creates inosinic acid, then a nucleotidase creates ... The enzyme is an allosteric enzyme, so it can be converted from IMP, GMP and AMP in high concentration binds the enzyme to ... So IMP, GMP and AMP are inhibitors while PRPP is an activator. Between the formation of 5'-phosphoribosyl, aminoimidazole and ...
... nucleotide deaminases MeSH D08.811.277.151.653.060 - amp deaminase MeSH D08.811.277.151.653.200 - dcmp deaminase MeSH D08.811. ... adenosine deaminase MeSH D08.811.277.151.486.250 - cytidine deaminase MeSH D08.811.277.151.486.625 - cytosine deaminase MeSH ... cyclic amp-dependent protein kinases MeSH D08.811.913.696.620.682.700.150.125.500 - beta-adrenergic-receptor kinase MeSH ... guanine deaminase MeSH D08.811.277.151.418 - methenyltetrahydrofolate cyclohydrolase MeSH D08.811.277.151.486 - nucleoside ...
... encoding enzyme AMP deaminase 3 API5: encoding protein Apoptosis inhibitor 5 APLNR: Apelin receptor (APJ receptor) APOA4: ...
... dCMP deaminase (DCTD) AMP deaminase (AMPD1) Adenosine Deaminase acting on tRNA (ADAT) Adenosine Deaminase acting on dsRNA (ADAR ... Adenosine Deaminase acting on mononucleotides (ADA) Guanine Deaminase (GDA) Adenosine monophosphate deaminase deficiency type 1 ... APOBEC1 APOBEC3A-H, APOBEC3G - affects HIV Activation-induced cytidine deaminase (AICDA) Cytidine deaminase (CDA) ... Enzymes that catalyse this reaction are called deaminases. In the human body, deamination takes place primarily in the liver, ...
... encoding enzyme AMP deaminase 2 ARID1A (1p36) ATXN7L2: Ataxin 7-like 2 AZIN2: encoding enzyme Antizyme inhibitor 2 (AzI2) also ...
... catalysed by the enzyme AMP deaminase: AMP + H2O → IMP + NH4+ The second stage is the formation of adenylosuccinate from IMP ... This reaction helps to dispose AMP produced after following reaction. ATP → ADP + Pi (utilisation of ATP for Muscle contraction ... The first stage is the deamination of the purine nucleotide Adenosine monophosphate (AMP) to form inosine monophosphate (IMP), ... AMP + Fumarate A recent study conducted by Sridharan et al. (AJP Cell Physiology, 2008, 295:C29-C37) showed that activation of ...
... 1 is an enzyme that in humans is encoded by the AMPD1 gene. Adenosine monophosphate deaminase is an enzyme that ... by directly inhibiting AMP deaminase, thereby increasing cellular AMP. It has been shown that in environments with high ... "Metformin activates AMP kinase through inhibition of AMP deaminase". J. Biol. Chem. 286 (1): 1-11. doi:10.1074/jbc.M110.121806 ... 1998). "Control of AMP deaminase 1 binding to myosin heavy chain". Am. J. Physiol. 275 (3 Pt 1): C870-81. doi:10.1152/ajpcell. ...
... is an enzyme that in humans is encoded by the AMPD2 gene. High AMPD2 expression levels correlate with poor ... Mahnke-Zizelman DK, Sabina RL (Nov 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene ... Bausch-Jurken MT, Mahnke-Zizelman DK, Morisaki T, Sabina RL (1992). "Molecular cloning of AMP deaminase isoform L. Sequence and ... Van den Bergh F, Sabina RL (1996). "Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative ...
AMP is normally converted into IMP by myoadenylate deaminase-so myoadenylate deaminase deficiency reduces energy that would be ... AMP deaminase is an enzyme that converts adenosine monophosphate (AMP) to inosine monophosphate (IMP), freeing an ammonia ... Fischer, H.; Esbjornsson, M.; Sabina, R. L.; Stromberg, A.; Peyrard-Janvid, M.; Norman, B. (2007). "AMP deaminase deficiency is ... The first effect-the loss of AMP-is mostly significant because AMP contains ribose, a sugar molecule that is also used to make ...
Turner, D.H. and Turner, J.F. (1961). "Adenylic deaminase of pea seeds". Biochem. J. 79: 143-147. PMID 13778717. ... AMP deaminaza (EC 3.5.4.6, adenilno kiselinska deaminaza, AMP aminaza, adenilna deaminaza, adenilatna deaminaza, 5-AMP ... Lee, Y.-P. (1957). "5′-Adenylic acid deaminase. III. Properties and kinetic studies". J. Biol. Chem. 227: 999-1007. PMID ... Lee, Y.-P. (1957). "5′-Adenylic acid deaminase. II. Homogeneity and physicochemical properties". J. Biol. Chem. 227: 993-998. ...
... a nucleotide found in RNA AMP deaminase, a human enzyme encoded by the AMPD1 gene Antimicrobial peptides, immune system ... Amp or AMP may refer to: Ampere, a unit of electric current, often shortened to amp Amplifier, a device that increases the ... 1997 compilation Amp (TV series), music video show The Amp, a British music video channel The Amp (St. Augustine), outdoor ... AMP Incorporated, U.S. electronic connector company AMP Limited, Australian financial services company Amp Electric Vehicles ...
Guanine deaminase. *Adenosine deaminase. *AMP deaminase. *Inosine monophosphate synthase. *DCMP deaminase. *GTP cyclohydrolase ...
Guanine deaminase. *Adenosine deaminase. *AMP deaminase. *Inosine monophosphate synthase. *DCMP deaminase. *GTP cyclohydrolase ...
In enzymology, an adenosine-phosphate deaminase (EC 3.5.4.17) is an enzyme that catalyzes the chemical reaction 5'-AMP + H2O ... Other names in common use include adenylate deaminase, adenine nucleotide deaminase, and adenosine (phosphate) deaminase. Su JC ... Yates MG (1969). "A non-specific adenine nucleotide deaminase from desulfovibrio desulfuricans". Biochim. Biophys. Acta. 171 (2 ... displaystyle \rightleftharpoons } 5'-IMP + NH3 Thus, the two substrates of this enzyme are 5'-AMP and H2O, whereas its two ...
... adenine deaminase EC 3.5.4.3: guanine deaminase EC 3.5.4.4: adenosine deaminase EC 3.5.4.5: cytidine deaminase EC 3.5.4.6: AMP ... pterin deaminase EC 3.5.4.12: dCMP deaminase EC 3.5.4.13: dCTP deaminase EC 3.5.4.14: deoxycytidine deaminase EC 3.5.4.15: ... adenosine-phosphate deaminase EC 3.5.4.18: ATP deaminase EC 3.5.4.19: phosphoribosyl-AMP cyclohydrolase EC 3.5.4.20: ... dCTP deaminase (dUMP-forming) EC 3.5.4.31: S-methyl-5'-thioadenosine deaminase EC 3.5.4.32: 8-oxoguanine deaminase EC 3.5.5.1: ...
... amp resistance - amplification - amplicon - anchor sequence - animal model - anneal - anti-sense strand - antibiotic resistance ... adenosine deaminase deficiency - adenovirus - agarose gel electrophoresis - agarose gel - Alagille syndrome - alkaline lysis - ...
... deaminase deficiency is a known cause of immunodeficiency. The adenosine analog NITD008 has been reported to directly ... Adenosine used as a second messenger can be the result of de novo purine biosynthesis via adenosine monophosphate (AMP), though ... When adenosine enters the circulation, it is broken down by adenosine deaminase, which is present in red blood cells and the ... Its derivatives include the energy carriers adenosine mono-, di-, and triphosphate, also known as AMP/ADP/ATP. Cyclic adenosine ...
Phillips, A.T.; Wood, W.A. (1964). "Basis for AMP activation of "Biodegradative" threonine dehydrase from". Biochemical and ... "Subunit structure of biodegradative threonine deaminase". The Journal of Biological Chemistry. 252 (7): 2206-8. PMID 321452. ...
Glutamine donates an ammonium group, which reacts with β-aspartyl-AMP to form asparagine and free AMP. ... In terms of regulation, the enzymes threonine deaminase, dihydroxy acid dehydrase, and transaminase are controlled by end- ... The enzyme asparagine synthetase produces asparagine, AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. In ... Phosphoribosyl-ATP converts to phosphoribosyl-AMP (PRAMP). His4 then catalyzes the formation of phosphoribosylformiminoAICAR- ...
AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity ... AICAR is able to enter the de novo synthesis pathway for adenosine synthesis to inhibit adenosine deaminase causing an increase ... A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229:558-565(1995) Galinanes M, ... Potential Role of AMP-Activated Protein Kinase. Pharmacology Toxicology 10-16 (2009).doi:10.1111/j.1742-7843.2009.00402.x Zhang ...
The AdK from mammalian sources, in addition to carrying out ATP-dependent phosphorylation of Ado, also catalyzes an Ado-AMP ... adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the ... Gupta RS (June 1996). "Adenosine-AMP exchange activity is an integral part of the mammalian adenosine kinase". Biochemistry and ... Explanation of exchange reaction between adenosine and AMP". The Journal of Biological Chemistry. 269 (27): 17820-5. PMID ...
aminoacyl-AMP + tRNA → aminoacyl-tRNA + AMP. Certain organisms can have one or more aminoacyl tRNA synthetases missing. This ... and adenosine deaminases in Eukarya), which increase the decoding capacity of a given tRNA.[31] As an example, tRNAAla encodes ...
monophosphates (AMP, GMP, UMP, CMP) · diphosphates (ADP, GDP, UDP, CDP) · triphosphates (ATP, GTP, TTP, UTP, CTP) ... Guanine deaminase. *cytosine. सन्दर्भ[संपादित करें]. *↑ Levy, Matthew; Stanley L. Miller, John Oró (August 1999). "Production ...
Adenosine is quickly broken down by adenosine deaminase, which is present in red cells and the vessel wall. ... AMP). Most of the adenosine that is produced leaves the cell and acts as a direct vasodilator on the vascular wall. Because ...
It is created from guanine by guanine deaminase.. *It is created from hypoxanthine by xanthine oxidoreductase. ... HT-AMP. *Ivermectin. *L-β,γ-Me-ATP. *MRS-2219. *PAPET-ATP ...
AMP) via adenylosuccinate (SAMP). ... Adenosine deaminase inhibitor (Pentostatin). *Halogenated/ ...
van Calker D, Müller M, Hamprecht B (1978). "Adenosine inhibits the accumulation of cyclic AMP in cultured brain cells". Nature ... EHNA is also a very potent adenosine deaminase inhibitor with an IC50 ~2 nM.[13] This dual inhibition would lead to the ... 1975). "Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic ... Although EHNA potently inhibits adenosine deaminase, it has been successfully used with the proper controls as a tool to probe ...
Adenosine deaminase inhibitor (Pentostatin). *Halogenated/ribonucleotide reductase inhibitors (Cladribine. *Clofarabine. * ...
AMP can be converted into IMP by the enzyme myoadenylate deaminase, freeing an ammonia group. In a catabolic pathway, adenosine ... AMP Or AMP may be produced by the hydrolysis of one high energy phosphate bond of ADP: ADP + H2O → AMP + Pi AMP can also be ... AMP is also a component in the synthesis of RNA. AMP is present in all known forms of life. AMP does not have the high energy ... AMP can be regenerated to ATP as follows: AMP + ATP → 2 ADP (adenylate kinase in the opposite direction) ADP + Pi → ATP (this ...
AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase). Studies of the soluble form of human ecto-5'nucleotidase, without ... association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity". Clinical Immunology and ... Fleit H, Conklyn M, Stebbins RD, Silber R (December 1975). "Function of 5'-nucleotidase in the uptake of adenosine from AMP by ... AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. ...
In parasitic protozoa such as giardia, APRTase provides the sole mechanism by which AMP can be produced. APRTase deficiency ... decreased purine nucleoside phosphorylase and adenosine deaminase activity". Blut. 39 (5): 309-15. doi:10.1007/BF01014193. PMID ... This functions as the nucleophile to attack the anomeric carbon of PRPP, forming AMP and displacing pyrophosphate from PRPP. ... After the phosphoribosyl transfer occurs, pyrophosphate leaves first, followed by AMP. Kinetic studies indicate that the ...
4CL forms a hydroxycinnamate-AMP anhydride, followed by a nucleophile attack on the carbonyl of the acyl adenylate. Cinnamoyl- ... Purification and properties of the phenylalanine deaminase of Hordeum vulgare". The Journal of Biological Chemistry. 236: 2692- ...
Reaction: amino acid + ATP → aminoacyl-AMP + PPi aminoacyl-AMP + tRNA → aminoacyl-tRNA + AMP Certain organisms can have one or ... and adenosine deaminases in Eukarya), which increase the decoding capacity of a given tRNA. As an example, tRNAAla encodes four ...
AMP deaminase 1 is an enzyme that in humans is encoded by the AMPD1 gene. Adenosine monophosphate deaminase is an enzyme that ... by directly inhibiting AMP deaminase, thereby increasing cellular AMP. It has been shown that in environments with high ... "Metformin activates AMP kinase through inhibition of AMP deaminase". J. Biol. Chem. 286 (1): 1-11. doi:10.1074/jbc.M110.121806 ... 1998). "Control of AMP deaminase 1 binding to myosin heavy chain". Am. J. Physiol. 275 (3 Pt 1): C870-81. doi:10.1152/ajpcell. ...
Expression patterns of AMP-deaminase isozymes in human hepatocellular carcinoma (HCC).. Mol. Cell. Biochem. null null 2008 ... AMP-deaminase (AMPD) is a large, well-conserved eukaryotic protein that catalyzes the hydrolytic deamination of adensosine ... In mammalian liver, the reaction catalysed by AMP-deaminase constitutes a rate-limiting step in adenine nucleotide catabolism [ ... monophosphate (AMP) to inosine monophosphate (IMP), and so plays an important role in purine metabolism. ...
AMP deaminase 2 is an enzyme that in humans is encoded by the AMPD2 gene. High AMPD2 expression levels correlate with poor ... Mahnke-Zizelman DK, Sabina RL (Nov 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene ... Bausch-Jurken MT, Mahnke-Zizelman DK, Morisaki T, Sabina RL (1992). "Molecular cloning of AMP deaminase isoform L. Sequence and ... Van den Bergh F, Sabina RL (1996). "Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative ...
Protein target information for AMP deaminase (pig). Find diseases associated with this biological target and compounds tested ...
Abstract 19495: Cardioprotective Effect of AMP Deaminase Inhibition in Oxygen Deprivation. Ryszard T Smolenski, Tomasz ... Studies on the effect of genetic polymorphisms known to affect AMP deaminase (AMPD) activity on progress of heart disease are ... Abstract 19495: Cardioprotective Effect of AMP Deaminase Inhibition in Oxygen Deprivation. Ryszard T Smolenski, Tomasz ... Abstract 19495: Cardioprotective Effect of AMP Deaminase Inhibition in Oxygen Deprivation. Ryszard T Smolenski, Tomasz ...
... metabolism through AMP deaminase (AMPD2) (summer) and activation of AMP-activated protein kinase (AMPK) (winter). Liver samples ... These data illuminate the opposing forces of metabolism of AMP by AMPD2 and its availability to activate AMPK as a switch that ... We hypothesized that this switch might be determined by AMP and the dominance of opposing effects: ...
By converting AMP to inosine monophosphate, AMPD1 plays a major role in regulating cellular AMP levels; AMP activates AMP ... codes for the muscle-specific form of the AMP deaminase enzyme (myoadenylate deaminase), which catalyzes the deamination of AMP ... We tested the candidate gene AMP deaminase 1 (AMPD1) for association with insulin-related traits because it codes for an enzyme ... Morisaki T, Gross M, Morisaki H, Pongratz D, Zollner N, Holmes EW: Molecular basis of AMP deaminase deficiency in skeletal ...
Reaction of rabbit skeletal-muscle AMP deaminase with a low molar excess of diethyl pyrocarbonate results in conversion of the ... Regulation of skeletal-muscle AMP deaminase: involvement of histidine residues in the pH-dependent inhibition of the rabbit ... Regulation of skeletal-muscle AMP deaminase: involvement of histidine residues in the pH-dependent inhibition of the rabbit ... Regulation of skeletal-muscle AMP deaminase: involvement of histidine residues in the pH-dependent inhibition of the rabbit ...
THE EFFECT OF AMP DEAMINASE 3 DEFICIENCY ON POST-MYOCARDIAL INFARCT FUNCTIONAL AND HISTOLOGICAL OUTCOMES IN MICE. ECU Author/ ... The purpose of this study was to use a mouse model to understand the effects of AMP deaminase 3 (AMPD3) deficiency on cardiac ... Abstract: PURPOSE: Humans deficient in the metabolic enzyme AMP deaminase 3 have improved survival and clinical outcomes in ... Furthermore , this study examined how AMP deaminase 3 deficiency impacted infarct size as well as molecular remodeling post- ...
Immunofluorescent and histochemical localization of AMP deaminase in skeletal muscle. B Ashby , B Ashby ... 252:1869--1872) that AMP deaminase forms a tight complex in solution with subfragment-2 (S-2) of myosin or with heavy ... B Ashby, C Frieden, R Bischoff; Immunofluorescent and histochemical localization of AMP deaminase in skeletal muscle.. J Cell ... A histoenzymatic method for the detection of AMP deaminase activity in cultured fibers gives comparable localization. The ...
AMP deaminase explanation free. What is AMP deaminase? Meaning of AMP deaminase medical term. What does AMP deaminase mean? ... Looking for online definition of AMP deaminase in the Medical Dictionary? ... AMP), adenine phosphoribosyltransferase (APRT) that converts adenine to AMP, AMP deaminase that converts AMP to IMP, inosine ... AMP deaminase , definition of AMP deaminase by Medical dictionary https://medical-dictionary.thefreedictionary.com/AMP+ ...
MalaCards integrated aliases for Erythrocyte Amp Deaminase Deficiency:. Name: Erythrocyte Amp Deaminase Deficiency 57 75 29 6 ... An important gene associated with Erythrocyte Amp Deaminase Deficiency is AMPD3 (Adenosine Monophosphate Deaminase 3). OMIM : ... MalaCards based summary : Erythrocyte Amp Deaminase Deficiency, is also known as adenosine monophosphate deaminase deficiency ... ClinVar genetic disease variations for Erythrocyte Amp Deaminase Deficiency:. 6 (show top 50) (show all 114) #. Gene. Variation ...
AMP Deaminase (AMPD: AMP [right arrow]IMP + NH3) isoform 1 is the dominant isoform in skeletal muscle, yet AMPD3 is robustly ... AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy. ... July 2018). AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy ( ... AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy. Masters ...
Hanson S, Ullman B. AMP deaminase and thymidine kinase deficiencies in a mutant mouse S49 cell clone. Advances in experimental ... Hanson, S. ; Ullman, B. / AMP deaminase and thymidine kinase deficiencies in a mutant mouse S49 cell clone. In: Advances in ... AMP deaminase and thymidine kinase deficiencies in a mutant mouse S49 cell clone. / Hanson, S.; Ullman, B. ... Hanson, S., & Ullman, B. (1989). AMP deaminase and thymidine kinase deficiencies in a mutant mouse S49 cell clone. Advances in ...
... from calf intestine and adenylate deaminase (AMPDA) from Aspergillus species has been evaluated and compared with that of the ... AMP Deaminase / chemistry * AMP Deaminase / metabolism* * Adenosine / chemistry* * Adenosine Deaminase / chemistry * Adenosine ... Activity of adenosine deaminase and adenylate deaminase on adenosine and 2, 3()-isopropylidene adenosine: role of the ... The deamination rate of 2,3-isopropylidene adenosine catalyzed by adenosine deaminase (ADA) from calf intestine and adenylate ...
... deaminase deficiency is a condition that can affect the muscles used for movement (skeletal muscles). Explore symptoms, ... AMP deaminase deficiency is caused by mutations in the AMPD1 gene, which provides instructions for producing an enzyme called ... The lack of AMP deaminase activity can result in fatigue, muscle weakness or pain, or other muscle problems in some people with ... AMP deaminase deficiency is one of the most common inherited muscle disorders in white populations, affecting 1 in 50 to 100 ...
papers/inhibition-by-alanine-of-amp-deaminase-from/9758. ... 2. The degree and type of inhibition of AMP-deaminase by ... Effects of some metabolic intermediates on AMP-deaminase activity in denervation atrophy. (opens in new tab) ... Purification and properties of AMP-deaminase from human uterine smooth muscle. (opens in new tab) ... 3. The probable significance of the effect of alanine on AMP-deaminase in muscle metabolism is discussed. ...
Hisatome, I., Morisake, T., Kamma, H., Sugama, T., Morisaki, H., Ohtahara, A. & Holmes, E. W. (1998). Control of AMP deaminase ... Sinkeler S. P., Binkhorst, R. A., Joosten, E. M., Wevers, R. A., Coerwinkei, M. M. & Oei, T. L. (1987). AMP deaminase ... Morisaki, T., Gross, M., Morisaki, H., Pongratz, D., Zollner, N. & Holmes, E. W. (1992). Molecular basis of AMP deaminase ... Norman, B., Mahnke-Zizelman, D. K., Vallis, A. & Sabina, R. L. (1998). Genetic and other determinants of AMP deaminase activity ...
Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation. Manual assertion according to rules ... IPR001365 A/AMP_deaminase_dom. IPR028892 ADE. IPR006330 Ado/ade_deaminase. IPR032466 Metal_Hydrolase. ... IPR001365 A/AMP_deaminase_dom. IPR028892 ADE. IPR006330 Ado/ade_deaminase. IPR032466 Metal_Hydrolase. ... sp,Q20YN2,ADE_RHOPB Adenine deaminase OS=Rhodopseudomonas palustris (strain BisB18) OX=316056 GN=RPC_4230 PE=3 SV=1 ...
IMP→AMP:. *Adenylosuccinate synthase. *Adenylosuccinate lyase. *reverse *AMP deaminase. IMP→GMP:. *IMP dehydrogenase ...
XMP is then converted into GMP by using the hydrolysis of 1 ATP and the conversion of glutamine to glutamate.[1] AMP and GMP ... Guanine is then deaminated via guanine deaminase to form xanthine which is then converted to uric acid. Oxygen is the final ... While IMP can be directly converted to AMP, synthesis of GMP (guanosine monophosphate) requires an intermediate step, in which ... The nucleoside, adenosine, is then deaminated and hydrolyzed to form hypoxanthine via adenosine deaminase and nucleosidase ...
erythrocyte AMP deaminase. erythrocyte type AMP deaminase. erythrocyte-specific AMP deaminase. myoadenylate deaminase. NP_ ... PLN03055; AMP deaminase; Provisional. TIGR01429. Location:146 → 753. AMP_deaminase; AMP deaminase. ... PLN03055; AMP deaminase; Provisional. TIGR01429. Location:153 → 760. AMP_deaminase; AMP deaminase. ... PLN03055; AMP deaminase; Provisional. TIGR01429. Location:146 → 753. AMP_deaminase; AMP deaminase. ...
AMP deaminase 1 gene polymorphism and heart disease-a genetic association that highlights new treatment.. Smolenski RT1, ... Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this ... We suggest therefore that pharmacological inhibition of AMP deaminase before transient ischemic event such as during ischemic ... increased production of adenosine and de-inhibition of AMP regulated protein kinase. Thus, genetic, clinical and biochemical ...
ADA, adenosine deaminase; cAMP, cyclic AMP; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase ... AMP or S-adenosylhomocysteine (SAH). Many cell types perform all the biological processes displayed in the figure, but some ...
AMP deaminase. 1. 0.002. 1. 1. S-Adenosylmethionine synthase 4. 0.76. 0.25. 0.44. ...
AMP-deaminase was partially purified from white skeletal muscle of goldfish, Carassius auratus. The enzyme was highly stable, ... AMP-deaminase from goldfish white muscle: Regulatory properties and redistribution under exposure to high environmental oxygen ... Lushchak, V.I. (Volodymyr I.), Husak, V.V. (Viktor V.), Storey, J, & Storey, K. (2009). AMP-deaminase from goldfish white ... AMP-aminohydrolase (AMPD) showed non-Michaelis-Menten kinetics, with a S0.5 (half saturation by the substrate) for AMP of 0.73 ...
A nucleotidase creates adenosine, then adenosine deaminase creates inosine. *Alternatively, AMP deaminase creates inosinic acid ... AMP[edit]. *adenylosuccinate synthase converts IMP to adenylosuccinate. *adenylosuccinate lyase converts adenylosuccinate into ... So IMP, GMP and AMP are inhibitors while PRPP is an activator. Between the formation of 5-phosphoribosyl, aminoimidazole and ... 1. Severe Immunodeficiency by loss of adenosine deaminase. 2. Hyperuricemia and Lesch-Nyhan syndrome by the loss of ...
IPR001365 A/AMP_deaminase_dom. IPR028893 A_deaminase. IPR006330 Ado/ade_deaminase. IPR032466 Metal_Hydrolase. ... IPR001365 A/AMP_deaminase_dom. IPR028893 A_deaminase. IPR006330 Ado/ade_deaminase. IPR032466 Metal_Hydrolase. ... Adenosine and AMP deaminases family. Adenosine deaminase subfamily.UniRule annotation. Manual assertion according to rulesi ... sp,A5U7Y8,ADD_MYCTA Adenosine deaminase OS=Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) OX=419947 GN=add PE=3 SV=1 ...
Adenosine/AMP deaminase domain (IPR001365) Pfam signature: PF00962 Cellulosome anchoring protein, cohesin domain (IPR002102) ... Porphobilinogen deaminase, N-terminal (IPR022417) Pfam signature: PF01379 Sugar isomerase (SIS) (IPR001347) Pfam signature: ... AMP-dependent synthetase/ligase (IPR000873) Pfam signature: PF00501 Phycobilisome, alpha/beta subunit (IPR012128) Pfam ... Cytidine and deoxycytidylate deaminase domain (IPR002125) Pfam signature: PF00383 Molybdopterin oxidoreductase (IPR006656) Pfam ...
DR InterPro; IPR001365; A/AMP_deaminase. DR Pfam; PF00962; A_deaminase; 2. DR HOGENOMDNA; LEMAJ1_4.PE32; -. KW CAC22679.1 ... AMP deaminase activity; IEA:EC. DR GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro. ... 3, Last annotation update) DE SubName: Full=Putative adenosine monophosphate deaminase; EC=3.5.4 6; DE (LEMAJ1_4.PE32). GN ... 20047545old_1320000031; KW putative adenosine monophosphate deaminase; KW Complete proteome; Hydrolase; Reference proteome. SQ ...
  • AMP-deaminase (AMPD) is a large, well-conserved eukaryotic protein that catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) to inosine monophosphate (IMP), and so plays an important role in purine metabolism. (ebi.ac.uk)
  • Studies on the effect of genetic polymorphisms known to affect AMP deaminase (AMPD) activity on progress of heart disease are conflicting: some highlights benefit of decreased AMPD activity in heart failure and ischemic heart disease while the other failed to confirm it. (ahajournals.org)
  • The activity of AMP regulated protein kinase (AMPK) in heart homogenates was measured following co-incubation with purified AMPD. (ahajournals.org)
  • The enzyme AMP deaminase (AMPD) (EC 3.5.4.6. (thefreedictionary.com)
  • AMP Deaminase (AMPD: AMP [right arrow]IMP + NH3) isoform 1 is the dominant isoform in skeletal muscle, yet AMPD3 is robustly upregulated during atrophy of skeletal muscle. (ecu.edu)
  • 1 Myoadenylate deaminase (AMPD) deficiency is present in 1-2 % of the population. (wiley.com)
  • Our other studies on the metabolic impact of AMPD1 C34T mutation revealed decrease in AMPD activity, increased production of adenosine and de-inhibition of AMP regulated protein kinase. (cdc.gov)
  • AMP-aminohydrolase (AMPD) showed non-Michaelis-Menten kinetics, with a S0.5 (half saturation by the substrate) for AMP of 0.73 ± 0.03 mM, a Hill coefficient of 2.01 ± 0.26, and a Vmax (maximum velocity) of 176 ± 46 U/mg protein. (carleton.ca)
  • An alternative pathway of AMP degradations is provided by the cytosolic enzyme AMP deaminase (AMPD), which catalyses the irreversible deamination of AMP to inosine monophosphate and ammonia. (clinicaltrials.gov)
  • AMP deaminase 1 is an enzyme that in humans is encoded by the AMPD1 gene. (wikipedia.org)
  • We tested the candidate gene AMP deaminase 1 ( AMPD1 ) for association with insulin-related traits because it codes for an enzyme that has the potential to influence multiple aspects of insulin pharmacodynamics. (diabetesjournals.org)
  • To begin to identify specific genes that mediate heritability of insulin-related phenotypes, we selected a candidate gene, AMP deaminase 1 ( AMPD1 ), which has been shown to influence skeletal muscle adenine nucleotide levels ( 7 ) and which in turn could have effects on other enzymes, such as AMP-activated protein kinase (AMPK), that are known to influence insulin action ( 8 ). (diabetesjournals.org)
  • AMP deaminase deficiency is caused by mutations in the AMPD1 gene, which provides instructions for producing an enzyme called AMP deaminase. (medlineplus.gov)
  • Mutations in the AMPD1 gene often result in an AMP deaminase enzyme that cannot function and as a result, energy production in skeletal muscle cells is decreased. (medlineplus.gov)
  • A G468-T AMPD1 mutant allele contributes to the high incidence of myoadenylate deaminase deficiency in the Caucasian population. (medlineplus.gov)
  • Myoadenylate deaminase deficiency caused by alternative splicing due to a novel intronic mutation in the AMPD1 gene. (medlineplus.gov)
  • Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this gene was found to benefit patients with heart failure and ischemic heart disease. (cdc.gov)
  • The AMPD1 gene encodes the enzyme adenosine monophosphate deaminase, which is one of the key enzymes used to process the energy source ATP. (snpedia.com)
  • Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L". Biochem. (wikipedia.org)
  • One punA gene, one adenosine kinase gene, one APRT gene, two AMP deaminase genes, two IMP dehydrogenase genes, three GMP synthase genes, and two guanine deaminase genes were successfully cloned (Figure S3, Supporting Information), and the corresponding proteins expressed in E. (thefreedictionary.com)
  • An important gene associated with Erythrocyte Amp Deaminase Deficiency is AMPD3 (Adenosine Monophosphate Deaminase 3). (malacards.org)
  • This gene encodes a member of the AMP deaminase gene family. (nih.gov)
  • Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. (nih.gov)
  • AMP deaminase 1 gene polymorphism and heart disease-a genetic association that highlights new treatment. (cdc.gov)
  • This study highlights the changes in umami-related nucleotide and glutamate levels when the AMP deaminase gene was elevated in transgenic tomato. (springer.com)
  • ADA (Adenosine Deaminase) is a Protein Coding gene. (genecards.org)
  • Gene Ontology (GO) annotations related to this gene include adenosine deaminase activity and purine nucleoside binding . (genecards.org)
  • GO annotations related to this gene include deaminase activity and AMP deaminase activity . (genecards.org)
  • The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. (nih.gov)
  • Moreover, we validated the direct and transcriptional regulatory effect of NovelmiRNA-25 on adenosine monophosphate deaminase 2 ( AMPD2 ) using a dual-luciferase reporter assay and western blot and confirmed AMPD2 mRNA and protein expression in PBMCs using qRT-PCR and western blot, respectively. (biomedcentral.com)
  • Cloning of human AMP deaminase isoform E cDNAs. (wikipedia.org)
  • 75 Adenosine monophosphate deaminase deficiency erythrocyte type: A metabolic disorder due to lack of activity of the erythrocyte isoform of AMP deaminase. (malacards.org)
  • The contribution of Ca+ calmodulin activation of human erythrocyte AMP deaminase (isoform E) to the erythrocyte metabolic dysregulation of familial phosphofructokinase deficiency. (nih.gov)
  • Calcium activates erythrocyte AMP deaminase [isoform E (AMPD3)] through a protein-protein interaction between calmodulin and the N-terminal domain of the AMPD3 polypeptide. (nih.gov)
  • In mammalian liver, the reaction catalysed by AMP-deaminase constitutes a rate-limiting step in adenine nucleotide catabolism [ PMID: 18493842 ]. (ebi.ac.uk)
  • In this biosynthetic pathway, purine nucleoside phosphorylase (punA) that converts adenosine to adenine, adenosine kinase that converts adenosine to adenosine 5'-monophosphate (AMP), adenine phosphoribosyltransferase (APRT) that converts adenine to AMP, AMP deaminase that converts AMP to IMP, inosine monophosphate (IMP) dehydrogenase that converts IMP to XMP, guanosine monophosphate (GMP) synthase that converts XMP to GMP, and guanine deaminase that converts GMP to guanine were, respectively, determined (Figure 1). (thefreedictionary.com)
  • 1,2) By reducing the catabolism of adenosine and adenine nucleotides, adenosine levels increase both directly and indirectly from dephosphorylation of AMP, particularly by 5'-ectonucleotidase. (thefreedictionary.com)
  • AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. (drugbank.ca)
  • Adenine deaminase activity was detected at low levels. (asm.org)
  • Adenine nucleosides and nucleotides are deaminated by adenosine deaminase and AMP deaminase to their corresponding inosine derivatives which, in turn, may be further degraded. (rcsb.org)
  • Adenosine monophosphate deaminase is an enzyme that converts adenosine monophosphate (AMP) to inosine monophosphate (IMP), freeing an ammonia molecule in the process. (wikipedia.org)
  • catalyzes the deamination of AMP to ammonia (N[H.sub.3]) and inosine monophosphate (IMP) in working skeletal muscle. (thefreedictionary.com)
  • Myoadenylate deaminase catalyses the reaction from adenosine monophosphate (AMP) to inosine monophosphate (IMP) plus ammonia (NH 3 ). (wiley.com)
  • A deficiency is associated with myoadenylate deaminase deficiency. (wikipedia.org)
  • Teijeira S, San Millán B, Fernández JM, Rivas E, Viéitez I, Miranda S, González F, Navarro C. Myoadenylate deaminase deficiency: clinico-pathological and molecular study of a series of 27 Spanish cases. (medlineplus.gov)
  • Additionally, the presence of an abnormal allele in some patients, such as with myoadenylate deaminase deficiency, may not result in a specific muscular disorder. (medscape.com)
  • Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. (wikipedia.org)
  • Reaction of rabbit skeletal-muscle AMP deaminase with a low molar excess of diethyl pyrocarbonate results in conversion of the enzyme into a species with one or two carbethoxylated histidine residues per subunit that retains sensitivity to ATP at pH 7.1 but, unlike the native enzyme, it is not sensitive to regulation by ATP at pH 6.5. (biochemj.org)
  • Immunofluorescent and histochemical localization of AMP deaminase in skeletal muscle. (rupress.org)
  • Adenosine monophosphate (AMP) deaminase deficiency is a condition that can affect the muscles used for movement (skeletal muscles). (medlineplus.gov)
  • Hanisch F, Joshi P, Zierz S. AMP deaminase deficiency in skeletal muscle is unlikely to be of clinical relevance. (medlineplus.gov)
  • AMP-deaminase was partially purified from white skeletal muscle of goldfish, Carassius auratus. (carleton.ca)
  • The purpose of this study was to use a mouse model to understand the effects of AMP deaminase 3 (AMPD3) deficiency on cardiac functionality after left anterior descending (LAD) artery ligation to simulate myocardial infarction. (uncg.edu)
  • A rare case of complete human erythrocyte AMP deaminase deficiency due to two novel missense mutations in AMPD3. (malacards.org)
  • Diseases associated with AMPD3 include Adenosine Monophosphate Deaminase Deficiency Erythrocyte Type and Adenosine Monophosphate Deaminase 1 Deficiency . (genecards.org)
  • We suggest therefore that pharmacological inhibition of AMP deaminase before transient ischemic event such as during ischemic heart disease or cardiac surgery could provide therapeutic benefit. (cdc.gov)
  • The deamination rate of 2',3'-isopropylidene adenosine catalyzed by adenosine deaminase (ADA) from calf intestine and adenylate deaminase (AMPDA) from Aspergillus species has been evaluated and compared with that of the enzymatic reactions of adenosine, to elucidate the influence of the protecting group on enzyme activity. (nih.gov)
  • Two different pyridoxal 5'-phosphate-containing l-threonine deaminases (EC 4.3.1.19), biosynthetic and biodegradative, which catalyze the deamination of l-threonine to alpha-ketobutyrate, are present in Escherichia coli and Salmonella typhimurium. (rcsb.org)
  • In a comprehensive mutant analysis involving single and multiple mutants of urate oxidase, xanthine dehydrogenase, nucleoside hydrolases, guanosine deaminase, and hypoxanthine guanine phosphoribosyltransferase, we demonstrate that purine nucleotide catabolism in Arabidopsis ( Arabidopsis thaliana ) mainly generates xanthosine, but not inosine and hypoxanthine, and that xanthosine is derived from guanosine deamination and a second source, likely xanthosine monophosphate dephosphorylation. (plantcell.org)
  • It is formed by the deamination of AMP and when hydrolysed produces inosine. (hmdb.ca)
  • Adenosine deaminase ( EC 3.5.4.4 ) catalyzes the hydrolytic deamination of adenosine into inosine and AMP deaminase ( EC 3.5.4.6 ) catalyzes the hydrolytic deamination of AMP into IMP. (embl.de)
  • Erythrocyte Amp Deaminase Deficiency, is also known as adenosine monophosphate deaminase deficiency erythrocyte type . (malacards.org)
  • Erythrocyte amp deaminase deficiency in Japanese: a compound heterozygote responsible for the complete deficiency. (malacards.org)
  • One controller of mitochondrial content is AMP-activated protein kinase (AMPK), which when bound by AMP activates PGC-1[alpha]leading to mitochondrial biogenesis and possibly greater mitochondrial content. (ecu.edu)
  • AMP-activated protein kinase (AMPK) activity plays a key role in inhibiting glomerular extracellular matrix accumulation mediated by TGF-β in diabetes 20 . (nature.com)
  • The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. (nih.gov)
  • Furthermore, the intracellular AMP/ATP ratio controls the activity of AMP-activated protein kinase, which is a potent energy regulator and is recently reported to play a role in the regulation of sleep homeostasis. (frontiersin.org)
  • Finally, we will address the possibility of an involvement of AMP-activated protein kinase (AMPK), a metabolic sensor, in sleep homeostasis. (frontiersin.org)
  • Adenosine acts through four G protein-coupled adenosine receptors that either stimulate (A 2A , A 2B ) or inhibit (A 1 , A 3 ) adenylate cyclase and thus enhance or decrease the second messenger cyclic AMP (cAMP). (nature.com)
  • Deaminases are enzymes that catalyze the hydrolysis of C-NH2 bonds in amino compounds, producing ammonia. (genecards.org)
  • 4 Degradation of adenosine by the enzymes adenosine deaminase and adenosine kinase, however, is confined to the intracellular compartment. (bmj.com)
  • Finally, extracellular adenosine is rapidly taken up into the cells and metabolized either into inosine by adenosine deaminase or into AMP by adenosine kinase. (nature.com)
  • Revertants of DTB6 cells possessed wild type levels of AMP deaminase activity but remained deficient in thymidine kinase activity, while another revertant of DTB6 cells expressed 11% of the wild type thymidine kinase level but did not perceptibly change its AMP deaminase activity. (elsevier.com)
  • The transgenic lines showed substantially enhanced levels of AMP deaminase expression in comparison to the wild-type control. (springer.com)
  • A research report shows that the widely prescribed diabetes medication metformin works on AMP-activated kinase (AMPK) by directly inhibiting AMP deaminase, thereby increasing cellular AMP. (wikipedia.org)
  • AMP activates AMP kinase, an enzyme that modulates cellular energy and insulin action. (diabetesjournals.org)
  • AMP deaminase and thymidine kinase deficiencies in a mutant mouse S49 cell clone. (elsevier.com)
  • From a mutagenized population of wild type S49 cells, a clone was isolated in a single step that possessed functional and biochemical deficiencies in both AMP deaminase and thymidine kinase activities. (elsevier.com)
  • Adenylate kinase and downstream AMP signaling is an integrated metabolic monitoring system which reads the cellular energy state in order to tune and report signals to metabolic sensors. (mdpi.com)
  • The production of IMP is regulated by the enzyme adenosine monophosphate (AMP) deaminase which functions to convert AMP into IMP. (springer.com)
  • A histoenzymatic method for the detection of AMP deaminase activity in cultured fibers gives comparable localization. (rupress.org)
  • its activity is dependent on AMP concentration. (thefreedictionary.com)
  • Diminishing activity of NAD: ICDH through repression or significant decrease in intracellular AMP concentration via the activation of AMP deaminase would result in the accumulation of citrate which serves as the precursor for ATP citrate lyase (ACL). (thefreedictionary.com)
  • First, DTB6 cells possessed a 60-70% deficiency in AMP deaminase activity, although the residual activity appeared kinetically similar to the wild type enzyme. (elsevier.com)
  • The lack of AMP deaminase activity can result in fatigue, muscle weakness or pain, or other muscle problems in some people with AMP deaminase deficiency. (medlineplus.gov)
  • AMP is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet. (drugbank.ca)
  • DNA polymorphisms affecting HO-1 and AMP-deaminase activity is assessed by DNA analysis. (clinicaltrials.gov)
  • Hypoxia in vitro and in vivo decreased purine oxidation and enhanced purine salvage reactions in human and mouse red blood cells, which was partly explained by decreased adenosine monophosphate deaminase activity. (haematologica.org)
  • Guanine deaminase activity was not detected. (asm.org)
  • At these time points, the activity of adenosine deaminase was measured in isolated lymphocytes, and forearm blood flow (FBF) was determined by venous occlusion plethysmography during administration of adenosine and dipyridamole into the brachial artery. (bmj.com)
  • PURPOSE: Humans deficient in the metabolic enzyme AMP deaminase 3 have improved survival and clinical outcomes in cases of revascularization , myocardial infarction , and/or heart failure. (uncg.edu)
  • Metabolomic analyses indicate that cellular, interstitial and blood AMP levels are potential metabolic signals associated with vital functions including body energy sensing, sleep, hibernation and food intake. (mdpi.com)
  • Elevated AMP deaminase levels resulted in the reduced accumulation of glutamate and increased levels of the umami nucleotide GMP. (springer.com)
  • Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. (drugbank.ca)
  • Adenosine is a purine-nucleoside that is formed both intra- and extracellularly by degradation of adenosine monophosphate (AMP) (fig 1). (bmj.com)
  • Under normal conditions adenosine is formed either by an intracellular 5`nucleotidase, which dephosphorylates AMP, or by the hydrolysis of S-adenosylhomcysteine by hydrolase. (clinicaltrials.gov)
  • Activation of protective AMPK cascade by increased availability of AMP could be the mechanism involved. (ahajournals.org)
  • [1] IMP is then converted to AMP ( adenosine monophosphate ) using GTP and aspartate, which is converted into fumarate . (wikipedia.org)
  • While IMP can be directly converted to AMP, synthesis of GMP ( guanosine monophosphate ) requires an intermediate step, in which NAD+ is used to form the intermediate xanthosine monophosphate , or XMP. (wikipedia.org)
  • Extracellular adenosine is generated predominantly through phosphohydrolysis of 5′-adenosine tri-/monophosphate (ATP/AMP). (nature.com)
  • Fischer H, Esbjörnsson M, Sabina RL, Strömberg A, Peyrard-Janvid M, Norman B. AMP deaminase deficiency is associated with lower sprint cycling performance in healthy subjects. (medlineplus.gov)
  • Defects in ADA are the cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID) [MIM:102700]. (abcam.com)
  • Coordinate induction of AMP deaminase in human atrium with mitochondrial DNA deletion. (nih.gov)
  • Szydlowska M, Roszkowska A. Expression patterns of AMP-deaminase isozymes in human hepatocellular carcinoma (HCC). (ebi.ac.uk)
  • The first committed step is the reaction of PRPP, glutamine and water to 5'-phosphoribosylamine (PRA), glutamate , and pyrophosphate - catalyzed by amidophosphoribosyltransferase , which is activated by PRPP and inhibited by AMP , GMP and IMP . (rug.nl)
  • Deletion of AMP deaminase (AMD1) attempts to rectify this by elevating intracellular ADP concentrations. (princeton.edu)
  • Although ATP and ADP concentrations in amd1Δtps1Δ following glucose upshift are more stable, the resulting increase in AMP concentrations may directly interfere with proper glycolytic regulation, resulting in less efficient glycolytic flux and energy production. (princeton.edu)
  • Researchers speculate that additional factors, both genetic and environmental, may determine whether a person develops the signs and symptoms of AMP deaminase deficiency. (medlineplus.gov)
  • This mutant cell line, DTB6, was selected in semi-solid medium containing 1mM thymidine and 1mM dibutyryl cyclic AMP. (elsevier.com)
  • Local tissue hypoxia that follows damage to endothelial cells and microcirculation and the interruption of normal blood and oxygen supply is associated with an increase in intracellular AMP, accumulation of intracellular adenosine, and subsequent transport or diffusion of intracellular adenosine into the extracellular space. (aacrjournals.org)