OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Clavulanic AcidAmoxicillin-Potassium Clavulanate CombinationAmoxicillinPotassiumClavulanic AcidsAnti-Bacterial AgentsPotassium Channelsbeta-LactamasesPenicillinsMicrobial Sensitivity Testsbeta-LactamsPenicillanic AcidSulbactamDrug Therapy, CombinationOtitis MediaClarithromycinbeta-Lactam ResistanceAmpicillinTicarcillinDrug Resistance, BacterialMetronidazoleStreptococcus pneumoniaeHaemophilus influenzaePenicillin ResistancePotassium Channel BlockersPotassium Channels, Inwardly RectifyingCefuroximePotassium, DietaryCephalosporinsLactamsPotassium DeficiencyHelicobacter pyloriAzithromycinPotassium Channels, Voltage-GatedPotassium CompoundsPiperacillinHelicobacter InfectionsActinomycetaceaeOmeprazoleCefotaxime2-PyridinylmethylsulfinylbenzimidazolesThienamycinsEnterobacteriaceaeCommunity-Acquired InfectionsPotassium IsotopesCephalosporinaseDrug Resistance, MicrobialBacteria, AnaerobicRespiratory Tract InfectionsBronchitis, Chronic
Clavulanic Acid: Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.Amoxicillin-Potassium Clavulanate Combination: A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.Potassium: An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.Clavulanic Acids: Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.beta-Lactamases: Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.Penicillins: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).beta-Lactams: Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)Sulbactam: A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Otitis Media: Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.beta-Lactam Resistance: Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.Ticarcillin: An antibiotic derived from penicillin similar to CARBENICILLIN in action.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).Streptococcus pneumoniae: A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.Haemophilus influenzae: A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.Penicillin Resistance: Nonsusceptibility of an organism to the action of penicillins.Potassium Channel Blockers: A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.Potassium Channels, Inwardly Rectifying: Potassium channels where the flow of K+ ions into the cell is greater than the outward flow.Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.Potassium, Dietary: Potassium or potassium compounds used in foods or as foods.Cephalosporins: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.Lactams: Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.Potassium Deficiency: A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing POLYURIA and decreased maximal urinary concentrating ability with secondary POLYDIPSIA. (Merck Manual, 16th ed)Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.Potassium Channels, Voltage-Gated: Potassium channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. The opening of these channels is induced by the membrane depolarization of the ACTION POTENTIAL.Potassium Compounds: Inorganic compounds that contain potassium as an integral part of the molecule.Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Actinomycetaceae: A family of bacteria including numerous parasitic and pathogenic forms.Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Cefotaxime: Semisynthetic broad-spectrum cephalosporin.2-Pyridinylmethylsulfinylbenzimidazoles: Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.Thienamycins: Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.Enterobacteriaceae: A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.Community-Acquired Infections: Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.Potassium Isotopes: Stable potassium atoms that have the same atomic number as the element potassium, but differ in atomic weight. K-41 is a stable potassium isotope.CephalosporinaseDrug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Bacteria, AnaerobicRespiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.Bronchitis, Chronic: A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.

Comparative in vitro activities of amoxicillin-clavulanate against aerobic and anaerobic bacteria isolated from antral puncture specimens from patients with sinusitis. (1/322)

By an agar dilution method, the antimicrobial susceptibilities of antral sinus puncture isolates were studied. Pneumococci were generally susceptible to amoxicillin, azithromycin, and clarithromycin, but 17% of pneumococcal isolates were resistant to cefuroxime. Haemophilus influenzae isolates were resistant to amoxicillin and clarithromycin. beta-Lactamase production occurred in 69% of Prevotella species. One-third of Peptostreptococcus magnus isolates were resistant to azithromycin and clarithromycin. Cefuroxime had limited activity against Prevotella species and P. magnus. Levofloxacin was active against most isolates except peptostreptococci. Amoxicillin-clavulanate was active against all isolates, with the MIC at which 90% of the isolates were inhibited being < or = 1 microgram/ml.  (+info)

Integron- and carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype typhimurium DT104 from French patients. (2/322)

Fifty-seven Salmonella enterica serotype Typhimurium (S. typhimurium) isolates were collected from human patients in two French hospitals, Hopital Antoine Beclere (Clamart, France) and Hopital Bicetre (Le Kremlin-Bicetre, France), between 1996 and 1997. Thirty of them (52 percent) were resistant to amino-, carbeni-, and ureidopenicillins, had reduced susceptibility to amoxicillin-clavulanic acid, were susceptible to cephalothin, and were resistant to sulfonamides, streptomycin, chloramphenicol, and tetracyclines. All these strains possessed a blaPSE-1-like gene and were of phage type DT104. Ten of them were studied in more detail, which revealed that blaPSE-1 is located on the variable region of a class 1 integron. This integron was found to be chromosomally located, as was another class 1 integron containing aadA2, a streptomycin-spectinomycin resistance gene. The reduced susceptibility to amoxicillin-clavulanic acid (and to ticarcillin-clavulanic acid) may result from the high level of hydrolysis of the beta-lactam rather than to the clavulanic acid resistance properties of PSE-1 in these clonally related S. typhimurium isolates.  (+info)

In vitro development of resistance to five quinolones and amoxicillin-clavulanate in Streptococcus pneumoniae. (3/322)

The ability of 50 sequential subcultures in subinhibitory concentrations of ciprofloxacin, levofloxacin, grepafloxacin, sparfloxacin, trovafloxacin, and amoxicillin-clavulanate to select for resistance was studied for six penicillin-susceptible and four penicillin-intermediate pneumococci. Subculturing in ciprofloxacin, grepafloxacin, levofloxacin, and sparfloxacin led to selection of mutants requiring increased MICs for all 10 strains, with MICs rising from (i) 0.5 to 4.0 to (ii) 4.0 to 32.0 microgram/ml after 7 to 12 passages for ciprofloxacin, from (i) 0.06 to 0.25 to (ii) 0.5 to 8.0 microgram/ml after 5 to 23 passages for grepafloxacin, from (i) 0.5 to 1.0 to (ii) 4.0 to 64 microgram/ml after 14 to 49 passages for levofloxacin, and from (i) 0.125 to 0.25 to (ii) 1.0 to 16.0 microgram/ml after 8 to 26 passages for sparfloxacin. Subculturing in trovafloxacin led to increased MICs for eight strains, with MICs rising from (i) 0.06 to 0.125 to (ii) 0.5 to 8.0 microgram/ml after 6 to 28 passages. Subculturing in amoxicillin-clavulanate led to raised MICs for only one strain, with the MIC rising from 0.015 to 0. 125 microgram/ml after 24 passages. Double mutations in both ParC and GyrA led to high-level quinolone resistance when ParC mutations were at S79. Trovafloxacin MICs were 1 to 2 microgram/ml in double mutants with ParC mutations at positions other than S79 (e.g., D83). Mutations in ParE (at D435, R447, and E474) and GyrB (at S405, D406, and D435) were found in four and six mutants, respectively. In the presence of reserpine, 29 mutants had lower ciprofloxacin MICs (2 to 16 times lower), 8 mutants had lower levofloxacin MICs (2 times), and one mutant had a lower trovafloxacin MIC (2 times), suggesting the involvement of an efflux mechanism. In contrast to the case for quinolones, subculturing in the presence of amoxicillin-clavulanate did not select for resistance to this drug.  (+info)

beta-lactamase production and antimicrobial susceptibility of oral heterogeneous Fusobacterium nucleatum populations in young children. (4/322)

Oral Fusobacterium nucleatum populations from 20 young, healthy children were examined for beta-lactamase production. Ten children (50%) harbored, altogether, 25 beta-lactamase-positive F. nucleatum isolates that were identified as F. nucleatum subsp. polymorphum, F. nucleatum subsp. nucleatum, and F. nucleatum subsp. vincentii (J. L. Dzink, M. T. Sheenan, and S. S. Socransky, Int. J. Syst. Bacteriol. 40:74-78, 1990). In vitro susceptibility of these beta-lactamase-producing and 26 non-beta-lactamase-producing F. nucleatum isolates was tested with penicillin G, amoxicillin-clavulanic acid, tetracycline hydrochloride, metronidazole, trovafloxacin, and azithromycin. Except for penicillin G, the antimicrobials exhibited good activity against all F. nucleatum isolates.  (+info)

Antibiotic use in patients admitted with acute exacerbations of chronic obstructive pulmonary disease. (5/322)

The objective of this report was to document the pattern of initial antibiotic prescribing in acute exacerbations of chronic obstructive pulmonary disease (COPD) in a hospital setting. All episodes of acute exacerbation of COPD, as diagnosed by the admitting doctor, in one hospital in the period January to May 1996, were identified. Case notes were reviewed retrospectively. Cases of radiographic pneumonia, bronchiectasis and incorrectly coded admissions were excluded. Symptoms, microbial cultures and initial antibiotic therapies were recorded. One hundred and fifty-nine patient episodes were identified; 40 were excluded yielding a sample of 119. Nineteen case notes were unavailable leaving a sample of 100 (84%) episodes. Eighty were treated with antibiotics on admission; amoxycillin was the most frequently prescribed, in 46 (58%) episodes. Of the antibiotic treated group, 42 (53%) patients were given dual therapy, most commonly a macrolide antibiotic with either amoxycillin or a cephalosporin. Intravenous treatment was used in 22 (28%) cases. The duration of intravenous treatment was >48 h in 12 (15%) cases. A total of 76 sputum samples were analysed from 55 patient episodes: 34 (45%) were culture positive. In 15 (27%) patient episodes, antibiotic therapy was changed or instituted on the basis of culture results. These data suggest that antibiotic treatment is not optimal, with overuse of antibiotics, especially intravenous and dual therapy.  (+info)

Co-amoxiclav affects cytokine production by human polymorphonuclear cells. (6/322)

Some antimicrobial agents have been reported to modify the host immune responses both in vivo and in vitro. As we demonstrated previously that co-amoxiclav had beneficial properties which result in enhancement of the microbicidal functions of human poly-morphonuclear cell (PMNs), we investigated the modulatory effect of this combination on cytokine production by human PMNs in vitro. The addition of co-amoxiclav elicited the production by lipopolysaccharide (LPS)-stimulated PMNs of substantial amounts of some cytokines, namely IL-8 and IL-1beta, after the addition of Klebsiella pneumoniae. These cytokine levels were higher than those obtained by PMNs incubated in culture medium only, without co-amoxiclav.  (+info)

Sensitivity of amoxicillin-resistant Helicobacter pylori to other penicillins. (7/322)

The sensitivities to penicillins and to a penicillin and beta-lactamase inhibitor combination agent were determined for Helicobacter pylori strains that were sensitive, moderately resistant, or highly resistant to amoxicillin. All strains were resistant to nafcillin and oxacillin. Moderately resistant strains showed an intermediate zone of inhibition to ticarcillin, mezlocillin, piperacillin, and amoxicillin-clavulanic acid. High-level resistance was associated with the smallest zone size for all penicillins tested.  (+info)

Differences between the activity of penicillin, amoxycillin, and co-amoxyclav against 5,252 Streptococcus pneumoniae isolates tested in the Alexander Project 1992-1996. (8/322)

A number of published studies have shown that the MICs of amoxycillin and/or co-amoxyclav are lower than those of ampicillin and/or penicillin for Streptococcus pneumoniae. Other published studies have concluded that the activities of amoxycillin and co-amoxyclav are comparable with that of penicillin for S. pneumoniae. A collection of 5252 S. pneumoniae isolates obtained during a 5 year period (1992-1996) was analysed to determine differences between the MICs of penicillin, amoxycillin and co-amoxyclav. Among the isolates analysed, 3788 (72%) were penicillin-susceptible, 615 (12%) were penicillin-intermediate and 849 (16%) were penicillin-resistant. Differences between the agents were assessed by examination of MIC distribution functions and simultaneous 95% CIs. In addition, penicillin-intermediate and -resistant isolates were analysed to determine the number and percentage of isolates which had an amoxycillin and co-amoxyclav MIC less than, equal to, or greater than the penicillin MIC. Results showed that the amoxycillin and co-amoxyclav MIC90s were one two-fold dilution lower than those of penicillin for all isolates collected between 1992-1993 and 1994-1996. Simultaneous 95% CIs showed that the mean differences between MICs of amoxycillin and penicillin, and between MICs of co-amoxyclav and penicillin, were less than zero. The majority of the penicillin-intermediate and penicillin-resistant isolates had an amoxycillin and co-amoxyclav MIC less than the penicillin MIC. In conclusion, amoxycillin and co-amoxyclav MICs were shown to be lower than the penicillin MICs for the S. pneumoniae isolates analysed in this study.  (+info)

OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Clavulanic AcidAmoxicillin-Potassium Clavulanate CombinationAmoxicillinPotassiumClavulanic AcidsAnti-Bacterial AgentsPotassium Channelsbeta-LactamasesPenicillinsMicrobial Sensitivity Testsbeta-LactamsPenicillanic AcidSulbactamDrug Therapy, CombinationOtitis MediaClarithromycinbeta-Lactam ResistanceAmpicillinTicarcillinDrug Resistance, BacterialMetronidazoleStreptococcus pneumoniaeHaemophilus influenzaePenicillin ResistancePotassium Channel BlockersPotassium Channels, Inwardly RectifyingCefuroximePotassium, DietaryCephalosporinsLactamsPotassium DeficiencyHelicobacter pyloriAzithromycinPotassium Channels, Voltage-GatedPotassium CompoundsPiperacillinHelicobacter InfectionsActinomycetaceaeOmeprazoleCefotaxime2-PyridinylmethylsulfinylbenzimidazolesThienamycinsEnterobacteriaceaeCommunity-Acquired InfectionsPotassium IsotopesCephalosporinaseDrug Resistance, MicrobialBacteria, AnaerobicRespiratory Tract InfectionsBronchitis, Chronic

*List of MeSH codes (D03)

... amoxicillin MeSH D03.438.260.825.750.050.050.060 --- amoxicillin-potassium clavulanate combination MeSH D03.438.260.825.750.050 ... amoxicillin MeSH D03.605.084.737.750.050.050.060 --- amoxicillin-potassium clavulanate combination MeSH D03.605.084.737.750.050 ... trimethoprim-sulfamethoxazole combination MeSH D03.383.773.050 --- anisomycin MeSH D03.383.773.107 --- bepridil MeSH D03.383. ...

*List of MeSH codes (D02)

... amoxicillin MeSH D02.065.589.099.750.750.050.050.060 --- amoxicillin-potassium clavulanate combination MeSH D02.065.589.099. ... amoxicillin-potassium clavulanate combination MeSH D02.065.589.099.500 --- monobactams MeSH D02.065.589.099.500.044 --- ... potassium acetate MeSH D02.241.081.038.208.025.800 --- sodium acetate MeSH D02.241.081.038.208.025.900 --- thioglycolates MeSH ... potassium citrate MeSH D02.241.081.944.509 --- pentanoic acids MeSH D02.241.081.944.509.350 --- gemfibrozil MeSH D02.241. ...

*Amoxicillin/clavulanic acid

It is a combination consisting of amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. It is ... "Amoxicillin and Clavulanate Potassium". The American Society of Health-System Pharmacists. Archived from the original on 29 ... This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin- ... Amoxicillin/clavulanic acid is banned from use in domestic-food animals (cattle, swine, etc.) in both the US and Europe; in the ...

*Clavulanic acid

In its most common form, the potassium salt potassium clavulanate is combined with: amoxicillin (co-amoxiclav, trade names ... Despite this, some bacterial strains that are resistant even to such combinations have emerged. The use of clavulanic acid with ... amoxicillin or amoxicillin-clavulanate potassium is preferred. The name is derived from strains of Streptomyces clavuligerus, ... "Drug Record - Amoxicillin-Clavulanate". LiverTox - Clinical and Research Information on Drug-Induced Liver Injury. Retrieved ...
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was the most common isolated pathogen. Although the reason for the disparities in the types of micro-organism is not obvious, it could be that environment plays a significant role in determining the types and frequency of micro-organisms isolated from urine. Excessive prescription of antibiotics, especially in non-bacterial infections has been identified as one of the causes of emergence of resistant strains.[21] In the present study, no correlation was made between frequency of antibiotic prescriptions and resistance pattern observed. However, amoxycillin-clavulanic acid which was most frequently prescribed had a sum resistance of 59.7 % in comparison to Ampiclox and cotrimoxazole that were less frequently prescribed with sum resistance of 62.6 % and 69.2 % respectively. The percentage resistance of microorganisms to antibiotics had earlier been used as a criterion to include or exclude such antibiotic from the list of choice agents for the treatment of UTI.[15] If this is extrapolated to this ...
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Two patients who developed a severe but reversible cholestatic jaundice during and after treatment with an amoxicillin/clavulanic acid preparation (Augmentin) are described. The diagnosis of drug-induced intrahepatic cholestasis was based on the clinical course, biochemical pattern and on histological findings. Since amoxicillin alone does not induce liver injury, the combination of amoxicillin and clavulanic acid or clavulanic acid alone could be responsible for this adverse reaction, probably through a metabolic idiosyncrasy or a hypersensitivity mechanism. Although more than 100 cases of hepatotoxic reactions have been reported to the pharmaceutical company (Beecham Laboratories) and several reports have been published, the incidence of hepatotoxicity of this antibiotic is relatively rare, since this antibiotic has been widely used. However, recognition of this benign and reversible cholestatic syndrome is important to avoid unnecessary, expensive and invasive diagnostic procedures ...
https://lirias.kuleuven.be/handle/123456789/44444
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Multiresistant strains of Haemophilus ducreyi, the aetiological agent of chancroid, are prevalent in Nairobi, Kenya, where tetracyclines and sulphonamides are no longer very effective in the treatment of chancroid. The following regimens (given three times daily for seven days) were compared in a double-blind randomised trial--amoxycillin 500 mg, amoxycillin 500 mg and clavulanic acid 125 mg, and amoxycillin 500 mg and clavulanic acid 250 mg. 68 of 100 ulcers were culture-positive for H. ducreyi. All strains of H. ducreyi produced beta-lactamase. At day 7 none of the amoxycillin-treated patients had responded clinically or bacteriologically, whereas all but 2 of 56 patients treated with an amoxycillin/clavulanic-acid regimen had responded clinically and H. ducreyi had been eradicated from their ulcers. The combination of amoxycillin-clavulanic acid appears to be very effective for the treatment of chancroid. The results of this study accord with H. ducreyi as the primary pathogen of chancroid ...
http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/31414
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more infohttps://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-016-1068-8

List of MeSH codes (D03) - WikipediaList of MeSH codes (D03) - Wikipedia

... amoxicillin MeSH D03.438.260.825.750.050.050.060 --- amoxicillin-potassium clavulanate combination MeSH D03.438.260.825.750.050 ... amoxicillin MeSH D03.605.084.737.750.050.050.060 --- amoxicillin-potassium clavulanate combination MeSH D03.605.084.737.750.050 ... trimethoprim-sulfamethoxazole combination MeSH D03.383.773.050 --- anisomycin MeSH D03.383.773.107 --- bepridil MeSH D03.383. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)

List of MeSH codes (D02) - WikipediaList of MeSH codes (D02) - Wikipedia

... amoxicillin MeSH D02.065.589.099.750.750.050.050.060 --- amoxicillin-potassium clavulanate combination MeSH D02.065.589.099. ... amoxicillin-potassium clavulanate combination MeSH D02.065.589.099.500 --- monobactams MeSH D02.065.589.099.500.044 --- ... potassium acetate MeSH D02.241.081.038.208.025.800 --- sodium acetate MeSH D02.241.081.038.208.025.900 --- thioglycolates MeSH ... potassium citrate MeSH D02.241.081.944.509 --- pentanoic acids MeSH D02.241.081.944.509.350 --- gemfibrozil MeSH D02.241. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)

Animal Bite Infections facts, information, pictures | Encyclopedia.com articles about Animal Bite InfectionsAnimal Bite Infections facts, information, pictures | Encyclopedia.com articles about Animal Bite Infections

Commonly prescribed antibiotics are penicillin or a combination of amoxicillin and clavulanate potassium. Aztreonam has been ... Commonly prescribed antibiotics are penicillin or a combination of amoxicillin and clavulanate potassium (Augmentin). Aztreonam ...
more infohttp://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/animal-bite-infections

Causes of swelling in one ankle and foot, knowledge deficit nursing diagnosis related to medication, 2011 ford raptor graphicsCauses of swelling in one ankle and foot, knowledge deficit nursing diagnosis related to medication, 2011 ford raptor graphics

A combination of amoxicillin and clavulanate potassium is effective for all human bite pathogens (3).. The disequilibrium of ...
more infohttp://s3.amazonaws.com/boredbed4survive/knowledge-deficit-nursing-diagnosis-related-to-medication.html
OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Clavulanic AcidAmoxicillin-Potassium Clavulanate CombinationAmoxicillinPotassiumClavulanic AcidsAnti-Bacterial AgentsPotassium Channelsbeta-LactamasesPenicillinsMicrobial Sensitivity Testsbeta-LactamsPenicillanic AcidSulbactamDrug Therapy, CombinationOtitis MediaClarithromycinbeta-Lactam ResistanceAmpicillinTicarcillinDrug Resistance, BacterialMetronidazoleStreptococcus pneumoniaeHaemophilus influenzaePenicillin ResistancePotassium Channel BlockersPotassium Channels, Inwardly RectifyingCefuroximePotassium, DietaryCephalosporinsLactamsPotassium DeficiencyHelicobacter pyloriAzithromycinPotassium Channels, Voltage-GatedPotassium CompoundsPiperacillinHelicobacter InfectionsActinomycetaceaeOmeprazoleCefotaxime2-PyridinylmethylsulfinylbenzimidazolesThienamycinsEnterobacteriaceaeCommunity-Acquired InfectionsPotassium IsotopesCephalosporinaseDrug Resistance, MicrobialBacteria, AnaerobicRespiratory Tract InfectionsBronchitis, Chronic
Beta-lactamasePatientsClavulanicAugmentinEfficacyDeterminationEscherichiaBacteriaFixed-ratioBacterialInfectionsDrugContextDrugsOralSide effectsHoursIncludeProductsCommonStudy

Beta-lactamase2

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Clavulanic7

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Augmentin1

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Escherichia1

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  • 12 weeks of age: 30 mg/kg/day divided every 12 hours, based on the amoxicillin component. (nih.gov)

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  • This study was conducted to determine the passage ratio of amoxicillin into milk and its pharmacokinetics in milk and plasma after intramuscular administration. (bioportfolio.com)