A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.
Substances that reduce the growth or reproduction of BACTERIA.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Therapy with two or more separate preparations given for a combined effect.
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Nonsusceptibility of an organism to the action of penicillins.
Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.
A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)
A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.
Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.
The L-isomer of Ofloxacin.
Inflammation of the middle ear with a clear pale yellow-colored transudate.
Inflammation of the tonsils, especially the PALATINE TONSILS but the ADENOIDS (pharyngeal tonsils) and lingual tonsils may also be involved. Tonsillitis usually is caused by bacterial infection. Tonsillitis may be acute, chronic, or recurrent.
The giving of drugs, chemicals, or other substances by mouth.
A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
A cyclohexylamido analog of PENICILLANIC ACID.
A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
Semisynthetic broad-spectrum cephalosporin.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A PEPTIC ULCER located in the DUODENUM.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
Gram-negative aerobic cocci of low virulence that colonize the nasopharynx and occasionally cause MENINGITIS; BACTEREMIA; EMPYEMA; PERICARDITIS; and PNEUMONIA.
A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.
Infections by bacteria, general or unspecified.
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.
Disease having a short and relatively severe course.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.
Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.
This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Increased RESPIRATORY RATE.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Infections with bacteria of the genus HAEMOPHILUS.
Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.
Impaired digestion, especially after eating.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The surgical removal of a tooth. (Dorland, 28th ed)
A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
Pain in the ear.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A plant genus of the family RANUNCULACEAE that contains alpha-hederin, a triterpene saponin in the seeds, and is the source of black seed oil.
Any tests done on exhaled air.
Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.
Inflammation of the lung parenchyma that is caused by bacterial infections.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Inflammation of the ear, which may be marked by pain (EARACHE), fever, HEARING DISORDERS, and VERTIGO. Inflammation of the external ear is OTITIS EXTERNA; of the middle ear, OTITIS MEDIA; of the inner ear, LABYRINTHITIS.
Translocation of body fluids from one compartment to another, such as from the vascular to the interstitial compartments. Fluid shifts are associated with profound changes in vascular permeability and WATER-ELECTROLYTE IMBALANCE. The shift can also be from the lower body to the upper body as in conditions of weightlessness.
Inflammation of the throat (PHARYNX).
Pathological processes involving the NASOPHARYNX.
Inflammation of the middle ear with purulent discharge.

Susceptibility of multidrug-resistant strains of Mycobacterium tuberculosis to amoxycillin in combination with clavulanic acid and ethambutol. (1/1164)

Thirty clinical isolates of Mycobacterium tuberculosis, 20 of which were multidrug-resistant (MDR), were tested for susceptibility to different combinations of amoxycillin, clavulanic acid and subinhibitory concentrations of ethambutol. beta-Lactamase production was assessed semiquantitatively with the nitrocefin method and susceptibility testing was performed with the BACTEC method. All isolates were beta-lactamase positive and were resistant to 16 mg/L amoxycillin. The MIC of amoxycillin in combination with clavulanic acid was > or =2 mg/L for 27/30 (90%) isolates. Addition of subinhibitory concentrations of ethambutol significantly reduced the MIC of amoxycillin for all tested isolates. Twenty-nine (97%) isolates had an MIC of amoxycillin of < or =0.5 mg/L when subinhibitory concentrations of ethambutol were added; this is well below the concentrations achievable in serum and tissue.  (+info)

Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study Group. (2/1164)

OBJECTIVES: To determine whether eradication of Helicobacter pylori relieves the symptoms of functional dyspepsia. DESIGN: Multicentre randomised double blind placebo controlled trial. SUBJECTS: 278 patients infected with H pylori who had functional dyspepsia. SETTING: Predominantly secondary care centres in Australia, New Zealand, and Europe. INTERVENTION: Patients randomised to receive omeprazole 20 mg twice daily, amoxicillin 1000 mg twice daily, and clarithromycin 500 mg twice daily or placebo for 7 days. Patients were followed up for 12 months. MAIN OUTCOME MEASURES: Symptom status (assessed by diary cards) and presence of H pylori (assessed by gastric biopsies and 13C-urea breath testing using urea labelled with carbon-13). RESULTS: H pylori was eradicated in 113 patients (85%) in the treatment group and 6 patients (4%) in the placebo group. At 12 months follow up there was no significant difference between the proportion of patients treated successfully by intention to treat in the eradication arm (24%, 95% confidence interval 17% to 32%) and the proportion of patients treated successfully by intention to treat in the placebo group (22%, 15% to 30%). Changes in symptom scores and quality of life did not significantly differ between the treatment and placebo groups. When the groups were combined, there was a significant association between treatment success and chronic gastritis score at 12 months; 41/127 (32%) patients with no or mild gastritis were successfully treated compared with 21/123 (17%) patients with persistent gastritis (P=0. 008). CONCLUSION: No convincing evidence was found that eradication of H pylori relieves the symptoms of functional dyspepsia 12 months after treatment.  (+info)

The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy. (3/1164)

AIM: To investigate the efficacy of two omeprazole triple therapies for the eradication of Helicobacter pylori, ulcer healing and ulcer relapse during a 6-month treatment-free period in patients with active duodenal ulcer. METHODS: This was a double-blind, randomized study in 15 centres across Canada. Patients (n = 149) were randomized to omeprazole 20 mg once daily (O) or one of two 1-week b. d. eradication regimens: omeprazole 20 mg, metronidazole 400 mg and clarithromycin 250 mg (OMC) or omeprazole 20 mg, amoxycillin 1000 mg and clarithromycin 500 mg (OAC). All patients were treated for three additional weeks with omeprazole 20 mg once daily. Ulcer healing was assessed by endoscopy after 4 weeks of study therapy. H. pylori eradication was determined by a 13C-urea breath test and histology, performed at pre-entry, at 4 weeks after the end of all therapy and at 6 months. RESULTS: The intention-to-treat (intention-to-treat) analysis contained 146 patients and the per protocol (per protocol) analysis, 114 patients. The eradication rates were (intention-to-treat/per protocol): OMC-85% and 92%, OAC-78% and 87% and O-0% (O). Ulcer healing (intention-to-treat) was greater than 90% in all groups. The differences in the eradication and relapse rates between O vs. OMC and O vs. OAC were statistically significant (all, P < 0.001). Treatment was well tolerated and compliance was high. CONCLUSION: The OMC and OAC 1-week treatment regimens are safe and effective for eradication, healing and the prevention of relapse in duodenal ulcer patients.  (+info)

The influence of metronidazole resistance on the efficacy of ranitidine bismuth citrate triple therapy regimens for Helicobacter pylori infection. (4/1164)

AIM: To assess the influence of metronidazole resistance on the efficacy of ranitidine bismuth citrate-based triple therapy regimens in two consecutive studies. METHODS: In the first study, patients with a culture-proven Helicobacter pylori infection were treated with ranitidine bismuth citrate 400 mg, metronidazole 500 mg, and clarithromycin 500 mg, all twice daily for 1 week (RMC). In the second study, amoxycillin 1000 mg was substituted for clarithromycin (RMA). Susceptibility testing for metronidazole was performed with the E-test. Follow-up endoscopy was performed after >/= 4 weeks. Antral biopsy samples were taken for histology and urease test, and culture and corpus samples for histology and culture. RESULTS: 112 patients, 53 males, age 55 +/- 14 years (39 duodenal ulcer, 7 gastric ulcer and 66 gastritis) were treated with RMC, and 89 patients, 52 males, age 58 +/- 15 years (23 duodenal ulcer, 7 gastric ulcer and 59 gastritis) were treated with RMA. For RMC, intention-to-treat eradication results were 98% (59/60, 95% CI: 91-100%) and 95% (20/21, 95% CI: 76-100%) for metronidazole susceptible and resistant strains, respectively (P = 0.45). For RMA these figures were 87% (53/61, 95% CI: 76-94%) for metronidazole susceptible strains and 22% (2/9, 95% CI: 3-60%) for resistant strains (P = 0.0001). CONCLUSION: Both regimens are effective in metronidazole susceptible strains. However, in contrast to the amoxycillin-containing regimen, that containing clarithromycin is also effective in resistant strains.  (+info)

Ampicillin-sulbactam and amoxicillin-clavulanate susceptibility testing of Escherichia coli isolates with different beta-lactam resistance phenotypes. (5/1164)

The activities of ampicillin-sulbactam and amoxicillin-clavulanate were studied with 100 selected clinical Escherichia coli isolates with different beta-lactam susceptibility phenotypes by standard agar dilution and disk diffusion techniques and with a commercial microdilution system (PASCO). A fixed ratio (2:1) and a fixed concentration (clavulanate, 2 and 4 micrograms/ml; sulbactam, 8 micrograms/ml) were used in the agar dilution technique. The resistance frequencies for amoxicillin-clavulanate with different techniques were as follows: fixed ratio agar dilution, 12%; fixed concentration 4-micrograms/ml agar dilution, 17%; fixed ratio microdilution, 9%; and disk diffusion, 9%. Marked discrepancies were found when these results were compared with those obtained with ampicillin-sulbactam (26 to 52% resistance), showing that susceptibility to amoxicillin-clavulanic acid cannot be predicted by testing the isolate against ampicillin-sulbactam. Interestingly, the discrimination between susceptible and intermediate isolates was better achieved with 4 micrograms of clavulanate per ml than with the fixed ratio. In contrast, amoxicillin susceptibility was not sufficiently restored when 2 micrograms of clavulanate per ml was used, particularly in moderate (mean beta-lactamase activity, 50.8 mU/mg of protein) and high-level (215 mU/mg) TEM-1 beta-lactamase producer isolates. Four micrograms of clavulanate per milliliter could be a reasonable alternative to the 2:1 fixed ratio, because most high-level beta-lactamase-hyperproducing isolates would be categorized as nonsusceptible, and low- and moderate-level beta-lactamase-producing isolates would be categorized as nonresistant. This approach cannot be applied to sulbactam, either with the fixed 2:1 ratio or with the 8-micrograms/ml fixed concentration, because many low-level beta-lactamase-producing isolates would be classified in the resistant category. These findings call for a review of breakpoints for beta-lactam-beta-lactamase inhibitors combinations.  (+info)

Effect of Helicobacter pylori eradication on the natural history of duodenal ulcer disease. (6/1164)

BACKGROUND: Duodenal ulcer disease is strongly associated with Helicobacter pylori infection of the gastric mucosa. Eradication of H pylori from the gastric mucosa in adults is associated with long term healing of ulcers. AIMS: To follow a cohort of children with duodenal ulcer disease for a minimum of two years after the eradication of H pylori. PATIENTS AND METHODS: Over a three year period, all children diagnosed with duodenal ulcer disease had their symptoms documented and their H pylori status evaluated. The histories of these children were carefully screened to determine previous symptoms and to document previous treatment regimens. RESULTS: Sixteen children were diagnosed with ulcers and 15 were available for treatment and long term follow up. The median age at which symptoms first occurred was 10.5 years (range, 6-14) and the median duration of symptoms was 24 months (range, 2-60). Ten of the children had been treated with H2 receptor antagonists for a median of 3.5 months (range, 1-60). Duodenal ulcers healed in all children after eradication of H pylori and all children have remained asymptomatic for a median of 37 months (range, 26-62). No child has required subsequent admission to hospital. CONCLUSION: Eradication of H pylori is very effective in the long term healing of duodenal ulcer disease. H pylori eradication should be the standard treatment for all infected children who present with duodenal ulcer disease.  (+info)

Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection. (7/1164)

AIM: To evaluate the efficacy of polaprezinc, a mucosal protective agent, in combination with a 7-day triple therapy containing lansoprazole, amoxycillin and clarithromycin, as a treatment for Helicobacter pylori. METHODS: Sixty-six consecutive patients suffering from dyspeptic symptoms with H. pylori infection were randomly allocated to one of two regimens: one group (LAC; n = 31) received lansoprazole 30 mg b.d., amoxycillin 500 mg b.d. and clarithromycin 400 mg b.d. for 7 days. The other group (LACP; n = 35) received the LAC regimen plus polaprezinc 150 mg b.d. for 7 days. H. pylori status was evaluated by rapid urease test, histology and culture at entry and 4 weeks after treatment. RESULTS: Five patients did not complete the treatment: no follow-up endoscopy was performed on two patients in the LAC group; one patient in the LAC group and two in the LACP group had their treatment stopped due to severe diarrhoea. By per protocol analysis, H. pylori eradication was achieved in 24 of the 28 evaluable patients (86%; 95% CI: 72-100%) after LAC therapy, and in 33 of the 33 evaluable patients (100%) after LACP therapy (P < 0.05). On intention-to-treat analysis, the rates of eradication were 24 of 31 patients (77%; 95% CI: 62-93%) in the LAC group, and 33 of 35 patients (94%; 95% CI: 86-100%) in the LACP group (P < 0.05). CONCLUSION: A 7-day triple therapy with lansoprazole, amoxycillin and clarithromycin is effective in H. pylori eradication, but this regimen is significantly improved by the addition of polaprezinc.  (+info)

Treatment options for Helicobacter pylori infection when proton pump inhibitor-based triple therapy fails in clinical practice. (8/1164)

BACKGROUND: The effectiveness of Helicobacter pylori eradication regimens has not been extensively investigated in the clinical practice setting. The optimal treatment choice after an initial failed eradication attempt has not been determined. AIMS: To evaluate proton pump inhibitor-based triple therapies as first-line eradication regimens in clinical practice, and to establish the efficacy of second-line regimens in the context of an initial failed eradication attempt. METHODS: Three hundred and eight patients with dyspepsia and evidence of H. pylori at endoscopy were recruited. As first-line therapy, 116 patients received omeprazole 20 mg b.d. in combination with amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. (OAC) while 192 patients received omeprazole 20 mg b.d. in combination with metronidazole 400 mg b.d. and clarithromycin 250 mg b.d. (OMC). H. pylori status was reassessed at least 4 weeks after therapy (25 patients failed to attend for further testing). Of 52 patients with an initial failed eradication attempt, 20 patients received a 1 week quadruple therapy regimen incorporating omeprazole 20 mg b.d., tripotassium dicitrato bismuthate 120 mg q.d.s., tetracycline 500 mg q.d.s. and metronidazole 400 mg t.d.s., 20 patients received a 2-week proton pump inhibitor-based triple therapy regimen as described, and 12 patients received a further 1-week proton pump inhibitor-based triple therapy regimen. RESULTS: Including 308 patients, the intention-to-treat (ITT) eradication rates for OAC and OMC as first-line regimens were 72% (95% CI: 63-80%) and 73% (95% CI: 67-79%) respectively. A per protocol (PP) analysis on the 283 patients who completed follow-up gives an initial eradication rate of 78% (95% CI: 69-86%) for OAC and 79% (95% CI: 73-85%) for OMC. There were 60 patients (21%; 95% CI: 17-26%) in whom the initial eradication attempt was unsuccessful. With second-line therapy, H. pylori was successfully eradicated in a further 35/52 (67%; 95% CI: 58-73%) patients. The eradication rates with the quadruple regimen and 2-week triple therapy regimens were 75% (95% CI: 56-94%) and 80% (95% CI: 63-98%) respectively (P = 0. 71). The eradication rate with a repeat 1-week regimen was 33% (95% CI: 7-60%). CONCLUSIONS: The eradication rates achieved in this 'in practice' study with recommended first-line 1-week proton pump inhibitor-based triple therapy regimens were lower than the rates achieved with similar regimens in the clinical trial setting. A repeat 1-week proton pump inhibitor-based triple therapy regimen was not successful as a salvage therapy. Both the 2-week proton pump inhibitor-based triple therapy regimen and the 1-week quadruple therapy regimen were successful second-line treatments in >/=75% of patients.  (+info)

1. Gastritis: Inflammation of the stomach lining, which can be acute or chronic.
2. Peptic ulcer disease: Ulcers in the stomach or duodenum (the first part of the small intestine) that are caused by H. pylori infection.
3. Gastric adenocarcinoma: A type of stomach cancer that is associated with long-term H. pylori infection.
4. Mucosa-associated lymphoid tissue (MALT) lymphoma: A rare type of cancer that affects the immune cells in the stomach and small intestine.
5. Gastroesophageal reflux disease (GERD): A condition in which stomach acid flows back up into the esophagus, causing symptoms such as heartburn and regurgitation.
6. Helicobacter pylori-associated chronic atrophic gastritis: A type of chronic inflammation of the stomach lining that can lead to stomach ulcers and stomach cancer.
7. Post-infectious irritable bowel syndrome (PI-IBS): A condition that develops after a gastrointestinal infection, characterized by persistent symptoms such as abdominal pain, bloating, and changes in bowel habits.

Helicobacter infections are typically diagnosed through endoscopy, where a flexible tube with a camera and light on the end is inserted into the stomach and small intestine to visualize the mucosa and look for signs of inflammation or ulcers. Laboratory tests such as breath tests and stool tests may also be used to detect the presence of H. pylori bacteria in the body. Treatment typically involves a combination of antibiotics and acid-suppressing medications to eradicate the infection and reduce symptoms.

Preventing Helicobacter Infections:

While it is not possible to completely prevent Helicobacter infections, there are several measures that can be taken to reduce the risk of developing these conditions:

1. Practice good hygiene: Wash your hands regularly, especially before eating and after using the bathroom.
2. Avoid close contact with people who have Helicobacter infections.
3. Avoid sharing food, drinks, or utensils with people who have Helicobacter infections.
4. Avoid consuming undercooked meat, especially pork and lamb.
5. Avoid consuming raw shellfish, especially oysters.
6. Avoid consuming unpasteurized dairy products.
7. Avoid alcohol and caffeine, which can irritate the stomach lining and increase the risk of developing Helicobacter infections.
8. Maintain a healthy diet that is high in fiber and low in fat.
9. Manage stress, as stress can exacerbate symptoms of Helicobacter infections.
10. Practice good oral hygiene to prevent gum disease and other oral infections that can increase the risk of developing Helicobacter infections.

Conclusion:

Helicobacter infections are a common cause of stomach ulcers, gastritis, and other gastrointestinal disorders. These infections are caused by the bacteria Helicobacter pylori, which can be found in the stomach lining and small intestine. While these infections can be difficult to diagnose, a combination of endoscopy, blood tests, and stool tests can help confirm the presence of Helicobacter bacteria. Treatment typically involves a combination of antibiotics and acid-suppressing medications to eradicate the infection and reduce symptoms. Preventive measures include practicing good hygiene, avoiding close contact with people who have Helicobacter infections, and maintaining a healthy diet.

* Earache (otalgia)
* Fever
* Hearing loss or muffled hearing
* Discharge from the ear
* Redness and swelling around the ear drum
* Fussiness or irritability in infants
* Loss of appetite or difficulty eating
* Difficulty sleeping

Otitis media is caused by a virus or bacteria that enters the middle ear through the Eustachian tube, which connects the back of the throat to the middle ear. The infection can spread quickly and cause inflammation in the middle ear, leading to hearing loss and other symptoms.

There are several types of otitis media, including:

* Acute otitis media: This is a sudden and severe infection that can develop over a few days. It is usually caused by a bacterial infection and can be treated with antibiotics.
* Otitis media with effusion (OME): This is a condition where fluid accumulates in the middle ear without an infection present. It can cause hearing loss and other symptoms but does not respond to antibiotics.
* Chronic suppurative otitis media (CSOM): This is a long-term infection that can cause persistent discharge, hearing loss, and other symptoms. It may require ongoing treatment with antibiotics and other therapies.

Otitis media can be diagnosed through a physical examination of the ear and a review of the patient's medical history. A doctor may also use tests such as a tympanocentesis (insertion of a small tube into the ear to collect fluid) or an otoscopic exam to confirm the diagnosis.

Treatment for otitis media depends on the type and severity of the infection, but may include:

* Antibiotics: To treat bacterial infections
* Pain relief medication: To help manage ear pain and fever
* Eardrops: To help clear fluid from the middle ear and reduce discharge
* Tympanocentesis: To collect fluid from the middle ear for testing or to relieve pressure
* Ventilation tubes: Small tubes that are inserted into the ear drum to allow air to enter the middle ear and help drain fluid.

It is important to seek medical attention if symptoms of otitis media persist or worsen over time, as untreated infections can lead to complications such as mastoiditis (an infection of the bones behind the ear) or meningitis (an infection of the lining around the brain and spinal cord). With prompt and appropriate treatment, however, most cases of otitis media can be effectively managed and hearing loss can be prevented.

Types of Pneumococcal Infections:

1. Pneumonia: This is an infection of the lungs that can cause fever, cough, chest pain, and difficulty breathing.
2. Meningitis: This is an infection of the membranes that cover the brain and spinal cord, which can cause fever, headache, stiff neck, and confusion.
3. Septicemia (bloodstream infection): This is an infection of the blood that can cause fever, chills, and low blood pressure.
4. Sinusitis: This is an infection of the sinuses, which can cause headache, facial pain, and difficulty breathing through the nose.
5. Otitis media (middle ear infection): This is an infection of the middle ear, which can cause ear pain, fever, and hearing loss.

Causes and Risk Factors:

Pneumococcal infections are caused by the bacteria Streptococcus pneumoniae. These bacteria can be spread through close contact with an infected person, such as touching or sharing food and drinks. People who are at high risk for developing pneumococcal infections include:

1. Children under the age of 5 and adults over the age of 65.
2. People with weakened immune systems, such as those with cancer, HIV/AIDS, or taking medications that suppress the immune system.
3. Smokers and people with chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease (COPD).
4. People who have recently had surgery or have a severe injury.
5. Those who live in long-term care facilities or have limited access to healthcare.

Prevention and Treatment:

Preventing pneumococcal infections is important, especially for high-risk individuals. Here are some ways to prevent and treat pneumococcal infections:

1. Vaccination: The pneumococcal conjugate vaccine (PCV) is recommended for children under the age of 5 and adults over the age of 65, as well as for people with certain medical conditions.
2. Hand washing: Frequent hand washing can help prevent the spread of pneumococcal bacteria.
3. Good hygiene: Avoiding close contact with people who are sick and regularly cleaning surfaces that may be contaminated with bacteria can also help prevent infection.
4. Antibiotics: Pneumococcal infections can be treated with antibiotics, but overuse of antibiotics can lead to the development of antibiotic-resistant bacteria. Therefore, antibiotics should only be used when necessary and under the guidance of a healthcare professional.
5. Supportive care: Those with severe pneumococcal infections may require hospitalization and supportive care, such as oxygen therapy or mechanical ventilation.

Conclusion:

Pneumococcal infections can be serious and even life-threatening, especially for high-risk individuals. Prevention and prompt treatment are key to reducing the risk of complications and improving outcomes. Vaccination, good hygiene practices, and appropriate antibiotic use are all important in preventing and treating pneumococcal infections. If you suspect that you or a loved one has a pneumococcal infection, it is essential to seek medical attention right away. With proper care and support, many people with pneumococcal infections can recover fully and resume their normal lives.

Ear Anatomy: The middle ear consists of three small bones called ossicles (the malleus, incus, and stapes) that transmit sound waves to the inner ear. The eardrum, a thin membrane, separates the outer ear canal from the middle ear. In OME, fluid accumulates in the middle ear, causing the eardrum to become congested and reducing its ability to vibrate properly.

Causes: There are several factors that can contribute to the development of OME, including:

1. Viral upper respiratory infections (such as the common cold)
2. Allergies
3. Enlarged adenoids or tonsils
4. Cystic fibrosis
5. Sinus infections
6. Meniere's disease
7. Head injury

Symptoms: The symptoms of OME can vary depending on the severity of the condition, but may include:

1. Hearing loss or muffled hearing
2. Discharge or fluid leaking from the ear
3. Pain or discomfort in the ear
4. Difficulty responding to sounds or understanding speech
5. Fever
6. Headache
7. Vertigo or dizziness
8. Loss of balance or coordination

Diagnosis: OME is typically diagnosed through a combination of physical examination, medical history, and ear examinations using an otoscope or tympanometry. A tympanogram may also be performed to measure the movement of the eardrum.

Treatment: The treatment of OME depends on the severity of the condition and may include:

1. Watchful waiting: In mild cases, OME may resolve on its own within a few weeks without any treatment.
2. Antibiotics: If there is a concurrent infection, antibiotics may be prescribed to treat the underlying infection.
3. Pain relief medication: Over-the-counter pain relief medication such as acetaminophen or ibuprofen may be recommended to relieve any discomfort or pain.
4. Eardrops: Eardrops containing antibiotics or steroids may be prescribed to treat the infection and reduce inflammation.
5. Tubes in the ear: In more severe cases, tubes may be placed in the ear drum to help drain fluid and relieve pressure.
6. Surgery: In rare cases, surgery may be necessary to remove the membrane or repair any damage to the middle ear bones.

Prognosis: The prognosis for OME is generally good, with most cases resolving within a few weeks without any long-term complications. However, in some cases, the condition can persist for longer periods of time and may lead to more serious complications such as hearing loss or mastoiditis.

Prevention: There is no specific way to prevent OME, but good ear hygiene and avoiding exposure to loud noises can help reduce the risk of developing the condition. Regular check-ups with an audiologist or otolaryngologist can also help identify any early signs of OME and prevent complications.

Conclusion: Otitis media with effusion (OME) is a common condition that affects children and adults, causing fluid buildup in the middle ear. While it is generally not a serious condition, it can cause discomfort and affect hearing. Treatment options range from watchful waiting to antibiotics and surgery, depending on the severity of the case. Good ear hygiene and regular check-ups with an audiologist or otolaryngologist can help prevent complications and ensure proper management of the condition.

The symptoms of tonsillitis can vary depending on the severity of the condition, but may include:

* Sore throat
* Swollen and tender tonsils
* Difficulty swallowing
* Fever
* Headache
* Bad breath
* Swelling of the lymph nodes in the neck

Tonsillitis is usually diagnosed based on a physical examination of the throat and lymph nodes, as well as a review of symptoms. In some cases, a tonsil culture may be performed to determine the cause of the infection.

Treatment for tonsillitis typically involves antibiotics to fight off bacterial infections, and supportive care such as pain relief medication and warm salt water gargles to help soothe the throat. In severe cases, surgical removal of the tonsils (tonsillectomy) may be necessary.

It is important to note that recurrent episodes of tonsillitis can be a sign of chronic tonsillitis, which may require more aggressive treatment. Additionally, tonsillitis can be a complication of other conditions such as mononucleosis (mono) or HIV/AIDS.

The main causes of duodenal ulcers are:

1. Infection with the bacterium Helicobacter pylori (H. pylori)
2. Overuse of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen
3. Excessive alcohol consumption
4. Smoking
5. Zollinger-Ellison syndrome, a rare condition that causes the stomach to produce too much acid

Symptoms of duodenal ulcers may include:

1. Abdominal pain, which can be worse when eating or at night
2. Nausea and vomiting
3. Bloating and gas
4. Acid reflux
5. Weight loss

Diagnosis of a duodenal ulcer typically involves a combination of endoscopy, where a flexible tube with a camera is inserted through the mouth to visualize the inside of the digestive tract, and breath tests to detect H. pylori infection.

Treatment for duodenal ulcers usually involves eradication of H. pylori infection, if present, and avoidance of NSAIDs and other irritants. Antacids or acid-suppressing medications may also be prescribed to help reduce symptoms and allow the ulcer to heal. In severe cases, surgery may be necessary.

Prevention of duodenal ulcers includes:

1. Avoiding NSAIDs and other irritants
2. Eradicating H. pylori infection
3. Quitting smoking and excessive alcohol consumption
4. Managing stress
5. Eating a healthy diet with plenty of fruits, vegetables, and whole grains

Prognosis for duodenal ulcers is generally good if treated promptly and effectively. However, complications such as bleeding, perforation, and obstruction can be serious and potentially life-threatening. It is important to seek medical attention if symptoms persist or worsen over time.

In conclusion, duodenal ulcers are a common condition that can cause significant discomfort and disrupt daily life. While they can be caused by a variety of factors, H. pylori infection is the most common underlying cause. Treatment typically involves eradication of H. pylori infection, avoidance of NSAIDs and other irritants, and management of symptoms with antacids or acid-suppressing medications. Prevention includes avoiding risk factors and managing stress. With prompt and effective treatment, the prognosis for duodenal ulcers is generally good. However, complications can be serious and potentially life-threatening, so it is important to seek medical attention if symptoms persist or worsen over time.

Some common examples of bacterial infections include:

1. Urinary tract infections (UTIs)
2. Respiratory infections such as pneumonia and bronchitis
3. Skin infections such as cellulitis and abscesses
4. Bone and joint infections such as osteomyelitis
5. Infected wounds or burns
6. Sexually transmitted infections (STIs) such as chlamydia and gonorrhea
7. Food poisoning caused by bacteria such as salmonella and E. coli.

In severe cases, bacterial infections can lead to life-threatening complications such as sepsis or blood poisoning. It is important to seek medical attention if symptoms persist or worsen over time. Proper diagnosis and treatment can help prevent these complications and ensure a full recovery.

Symptoms of pneumococcal pneumonia can include fever, cough, chest pain, shortness of breath, and difficulty breathing. In severe cases, the infection can spread to the bloodstream and cause sepsis, a life-threatening condition that requires immediate medical attention.

Pneumococcal pneumonia is most commonly seen in young children, older adults, and people with weakened immune systems, such as those with cancer, HIV/AIDS, or taking immunosuppressive medications. It is usually diagnosed through a combination of physical examination, medical history, and diagnostic tests such as chest X-rays and blood cultures.

Treatment of pneumococcal pneumonia typically involves antibiotics to eliminate the bacterial infection. In severe cases, hospitalization may be necessary to provide oxygen therapy, fluid replacement, and other supportive care. Vaccines are also available to prevent Streptococcus pneumoniae infections, particularly in children and older adults.

Prevention measures for pneumococcal pneumonia include:

* Vaccination: The pneumococcal conjugate vaccine (PCV) is recommended for children under the age of 2 and older adults over the age of 65, as well as for people with certain medical conditions.
* Good hygiene: Regular handwashing and avoiding close contact with people who are sick can help prevent the spread of the infection.
* Avoiding smoking: Smoking can damage the lungs and increase the risk of infection.
* Keeping up-to-date on recommended vaccinations: Staying current on recommended vaccinations, such as the flu shot, can help prevent secondary bacterial infections like pneumococcal pneumonia.
* Managing underlying conditions: People with certain medical conditions, such as diabetes or chronic lung disease, should work with their healthcare provider to manage their condition and reduce their risk of developing pneumococcal pneumonia.

It's important to seek medical attention right away if you or someone you know is experiencing symptoms of pneumococcal pneumonia, as early treatment can help prevent complications and improve outcomes.

Examples of acute diseases include:

1. Common cold and flu
2. Pneumonia and bronchitis
3. Appendicitis and other abdominal emergencies
4. Heart attacks and strokes
5. Asthma attacks and allergic reactions
6. Skin infections and cellulitis
7. Urinary tract infections
8. Sinusitis and meningitis
9. Gastroenteritis and food poisoning
10. Sprains, strains, and fractures.

Acute diseases can be treated effectively with antibiotics, medications, or other therapies. However, if left untreated, they can lead to chronic conditions or complications that may require long-term care. Therefore, it is important to seek medical attention promptly if symptoms persist or worsen over time.

The common types of RTIs include:

1. Common cold: A viral infection that affects the upper respiratory tract, causing symptoms such as runny nose, sneezing, coughing, and mild fever.
2. Influenza (flu): A viral infection that can affect both the upper and lower respiratory tract, causing symptoms such as fever, cough, sore throat, and body aches.
3. Bronchitis: An inflammation of the bronchial tubes, which can be caused by viruses or bacteria, resulting in symptoms such as coughing, wheezing, and shortness of breath.
4. Pneumonia: An infection of the lungs that can be caused by bacteria, viruses, or fungi, leading to symptoms such as fever, chills, coughing, and difficulty breathing.
5. Tonsillitis: An inflammation of the tonsils, which can be caused by bacteria or viruses, resulting in symptoms such as sore throat, difficulty swallowing, and bad breath.
6. Sinusitis: An inflammation of the sinuses, which can be caused by viruses, bacteria, or fungi, leading to symptoms such as headache, facial pain, and nasal congestion.
7. Laryngitis: An inflammation of the larynx (voice box), which can be caused by viruses or bacteria, resulting in symptoms such as hoarseness, loss of voice, and difficulty speaking.

RTIs can be diagnosed through physical examination, medical history, and diagnostic tests such as chest X-rays, blood tests, and nasal swab cultures. Treatment for RTIs depends on the underlying cause and may include antibiotics, antiviral medications, and supportive care to manage symptoms.

It's important to note that RTIs can be contagious and can spread through contact with an infected person or by touching contaminated surfaces. Therefore, it's essential to practice good hygiene, such as washing hands frequently, covering the mouth and nose when coughing or sneezing, and avoiding close contact with people who are sick.

A peptic ulcer is a break in the lining of the stomach or duodenum (the first part of the small intestine), which can cause pain and bleeding. The stomach acid and digestive enzymes flowing through the ulcer can irritate the surrounding tissue, leading to inflammation and discomfort.

Peptic ulcers are commonly caused by an infection with Helicobacter pylori (H. pylori) bacteria or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or aspirin. Other contributing factors include stress, smoking, and excessive alcohol consumption.

Symptoms of a peptic ulcer may include abdominal pain, nausea, vomiting, and loss of appetite. Treatment options typically involve antibiotics to eradicate H. pylori infection or stopping NSAID use, along with medications to reduce acid production in the stomach and protect the ulcer from further damage. Surgery may be necessary for severe cases or if other treatments fail.

Prevention methods include avoiding NSAIDs, maintaining a healthy lifestyle, managing stress, and getting regular screenings for H. pylori infection. Early detection and proper treatment can help alleviate symptoms and prevent complications such as ulcer perforation or bleeding.

In summary, peptic ulcers are painful and potentially harmful conditions that can be caused by various factors. Proper diagnosis and treatment are essential to prevent complications and improve quality of life.

Symptoms of a UTI can include:

* Painful urination
* Frequent urination
* Cloudy or strong-smelling urine
* Blood in the urine
* Pelvic pain in women
* Rectal pain in men

If you suspect that you have a UTI, it is important to seek medical attention as soon as possible. UTIs can lead to more serious complications if left untreated, such as kidney damage or sepsis.

Treatment for a UTI typically involves antibiotics to clear the infection. It is important to complete the full course of treatment to ensure that the infection is completely cleared. Drinking plenty of water and taking over-the-counter pain relievers may also help alleviate symptoms.

Preventive measures for UTIs include:

* Practicing good hygiene, such as wiping from front to back and washing hands after using the bathroom
* Urinating when you feel the need, rather than holding it in
* Avoiding certain foods that may irritate the bladder, such as spicy or acidic foods
* Drinking plenty of water to help flush bacteria out of the urinary tract.

The diagnosis of tachypnea is based on physical examination, medical history, and diagnostic tests such as chest x-rays, electrocardiograms (ECG), and blood tests. Treatment depends on the underlying cause, and may include oxygen therapy, antibiotics, or other medications to manage symptoms.

In severe cases of tachypnea, mechanical ventilation may be required to support breathing. It is important to monitor the patient's condition closely and provide appropriate treatment to prevent complications such as respiratory failure, cardiac arrest, or sepsis.

Tachypnea can be a serious condition and should be evaluated by a healthcare professional promptly.

Types of Drug Eruptions:

1. Maculopapular exanthema (MPE): This is a common type of drug eruption characterized by flat, red patches on the skin that may be accompanied by small bumps or hives. MPE typically occurs within 1-2 weeks of starting a new medication and resolves once the medication is discontinued.
2. Stevens-Johnson syndrome (SJS): This is a more severe type of drug eruption that can cause blisters, skin sloughing, and mucosal lesions. SJS typically occurs within 2-4 weeks of starting a new medication and can be life-threatening in some cases.
3. Toxic epidermal necrolysis (TEN): This is a severe, life-threatening type of drug eruption that can cause widespread skin death and mucosal lesions. TEN typically occurs within 2-4 weeks of starting a new medication and requires immediate hospitalization and treatment.

Causes of Drug Eruptions:

1. Allergic reactions to medications: This is the most common cause of drug eruptions. The body's immune system overreacts to certain medications, leading to skin symptoms.
2. Adverse effects of medications: Certain medications can cause skin symptoms as a side effect, even if the person is not allergic to them.
3. Infections: Bacterial, fungal, or viral infections can cause drug eruptions, particularly if the medication is used to treat the infection.
4. Autoimmune disorders: Certain autoimmune disorders, such as lupus or rheumatoid arthritis, can increase the risk of developing drug eruptions.

Diagnosis and Treatment of Drug Eruptions:

1. Medical history and physical examination: A thorough medical history and physical examination are essential to diagnose a drug eruption. The healthcare provider will look for patterns of skin symptoms that may be related to a specific medication.
2. Skin biopsy: In some cases, a skin biopsy may be necessary to confirm the diagnosis of a drug eruption and to rule out other conditions.
3. Medication history: The healthcare provider will ask about all medications taken by the patient, including over-the-counter medications and supplements.
4. Treatment: Depending on the severity of the drug eruption, treatment may include stopping the offending medication, administering corticosteroids or other immunosuppressive medications, and providing supportive care to manage symptoms such as itching, pain, and infection. In severe cases, hospitalization may be necessary.
5. Monitoring: Patients with a history of drug eruptions should be closely monitored by their healthcare provider when starting new medications, and any changes in their skin should be reported promptly.

Prevention of Drug Eruptions:

1. Allergy testing: Before starting a new medication, the healthcare provider may perform allergy testing to determine the patient's sensitivity to specific medications.
2. Medication history: The healthcare provider should take a thorough medication history to identify potential allergens and avoid prescribing similar medications that may cause an adverse reaction.
3. Gradual introduction of new medications: When starting a new medication, it is recommended to introduce the medication gradually in small doses to monitor for any signs of an adverse reaction.
4. Monitoring: Patients should be closely monitored when starting new medications, and any changes in their skin or symptoms should be reported promptly to their healthcare provider.
5. Avoiding certain medications: In some cases, it may be necessary to avoid certain medications that are more likely to cause a drug eruption based on the patient's medical history and other factors.

Conclusion:

Drug eruptions can present with various symptoms and can be challenging to diagnose. A thorough medical history and physical examination are essential to diagnose a drug eruption. Treatment depends on the severity of the reaction and may include stopping the offending medication, administering corticosteroids, and providing supportive care. Prevention is key, and healthcare providers should be aware of potential allergens and take steps to minimize the risk of adverse reactions. By being vigilant and proactive, healthcare providers can help prevent drug eruptions and ensure the best possible outcomes for their patients.

Epidemiology of Haemophilus Infections:

* Incidence: Hib disease was once a major cause of childhood meningitis and sepsis, but the introduction of Hib vaccines in the 1980s has significantly reduced the incidence of invasive Hib disease. Non-invasive Hib disease, such as otitis media, is still common.
* Prevalence: Hib is the leading cause of bacterial meningitis in children under the age of 5 worldwide. In developed countries, the prevalence of invasive Hib disease has decreased significantly since the introduction of vaccines, but it remains a significant public health problem in developing countries.
* Risk factors: young age, poverty, lack of access to healthcare, and poor sanitation and hygiene are risk factors for Hib disease. Children under the age of 5, especially those under the age of 2, are at highest risk for invasive Hib disease.

Pathophysiology of Haemophilus Infections:

* Mechanisms of infection: H. influenzae can cause both respiratory and non-respiratory infections by colonizing the nasopharynx and other mucosal surfaces. The bacteria can then disseminate to other parts of the body, causing invasive disease.
* Immune response: the immune response to Hib infection involves both humoral and cell-mediated immunity. Antibodies play a crucial role in protecting against reinfection, while T cells and macrophages help to clear the bacteria from the body.

Clinical Presentation of Haemophilus Infections:

* Respiratory infections: H. influenzae can cause various respiratory tract infections, including bronchitis, pneumonia, and sinusitis. Symptoms may include fever, cough, sore throat, and difficulty breathing.
* Non-respiratory infections: Hib can cause a range of non-respiratory infections, including meningitis, epiglottitis, and septic arthritis. These infections can have more severe symptoms and may require prompt medical attention.

Diagnosis of Haemophilus Infections:

* Diagnostic tests: diagnosis of Hib disease is based on a combination of clinical findings, laboratory tests, and radiologic studies. Blood cultures, lumbar puncture, and chest x-rays may be used to confirm the presence of the bacteria and assess the extent of infection.
* Laboratory testing: identification of Hib is based on its distinctive gram stain appearance and biochemical characteristics. Polymerase chain reaction (PCR) and DNA sequencing are also used to confirm the diagnosis.

Treatment and Prevention of Haemophilus Infections:

* Antibiotics: Hib infections are treated with antibiotics, such as amoxicillin or ceftriaxone. The choice of antibiotic depends on the severity and location of the infection.
* Vaccination: the Hib vaccine is recommended for children under 5 years old to prevent Hib disease. The vaccine is given in a series of 3-4 doses, with the first dose given at 2 months of age.
* Good hygiene practices: good hygiene practices, such as frequent handwashing and proper cleaning and disinfection, can help prevent the spread of Hib bacteria.

Complications of Haemophilus Infections:

* Meningitis: Hib meningitis can have serious complications, including hearing loss, learning disabilities, and seizures.
* Permanent brain damage: Hib infections can cause permanent brain damage, including cognitive and behavioral impairments.
* Respiratory failure: severe Hib pneumonia can lead to respiratory failure, which may require mechanical ventilation.
* Death: Hib infections can be life-threatening, especially in young children and those with underlying medical conditions.

In conclusion, Haemophilus infections are a serious public health concern, particularly for young children and those with underlying medical conditions. Prevention through vaccination and good hygiene practices is essential to reduce the risk of infection. Early diagnosis and treatment are critical to prevent complications and improve outcomes.

* Nasal congestion and discharge
* Headaches
* Pain and pressure in the face, particularly in the cheeks and forehead
* Fatigue and fever
* Loss of smell or taste

There are several types of sinusitis, including:

* Acute sinusitis: This type of sinusitis is caused by a sudden infection and typically lasts for less than four weeks.
* Chronic sinusitis: This type of sinusitis is caused by a long-term infection or inflammation that persists for more than 12 weeks.
* Recurrent sinusitis: This type of sinusitis occurs when acute sinusitis keeps coming back, often due to repeat infections or allergies.
* Allergic fungal sinusitis: This type of sinusitis is caused by an allergic reaction to fungus that grows in the sinuses.
* Chronic rhinosinusitis: This type of sinusitis is characterized by chronic inflammation and nasal congestion, often due to an allergic response.

Treatment for sinusitis depends on the underlying cause and may include antibiotics, antihistamines, decongestants, nasal saline irrigations, or surgery. It is important to seek medical attention if symptoms persist or worsen over time, as untreated sinusitis can lead to complications such as meningitis or brain abscess.

Dyspepsia is not a specific disease but rather a symptom complex that can be caused by a variety of factors, such as:

1. Gastritis (inflammation of the stomach lining)
2. Peptic ulcer
3. Gastroesophageal reflux disease (GERD)
4. Functional dyspepsia
5. Inflammatory conditions such as Crohn's disease or ulcerative colitis
6. Food allergies or intolerances
7. Hormonal changes during pregnancy or menstruation
8. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotics

The diagnosis of dyspepsia is based on a combination of medical history, physical examination, and diagnostic tests such as endoscopy, gastric emptying studies, and blood tests. Treatment depends on the underlying cause of dyspepsia and may include medications, lifestyle changes, and dietary modifications.

An earache is a type of pain that occurs in one or both ears. It can be a sharp, dull, throbbing, or piercing sensation that may be accompanied by other symptoms such as hearing loss, ringing in the ears (tinnitus), or difficulty responding to sounds. Earaches can be caused by a variety of factors, including ear infections, fluid buildup, allergies, and injuries.

Earache Symptoms

The symptoms of an earache may include:

* Pain or discomfort in one or both ears
* Hearing loss or muffled hearing
* Ringing or buzzing sounds in the ears (tinnitus)
* Difficulty responding to sounds or understanding speech
* Fever or headache
* Discharge or fluid leaking from the ear
* Redness or swelling of the ear canal or eardrum

Earache Causes

Earaches can be caused by a variety of factors, including:

* Ear infections (otitis media)
* Fluid buildup in the middle ear (otitis media with effusion)
* Allergies
* Injuries to the head or ear
* Certain medications
* Poor Eustachian tube function

Earache Diagnosis

A healthcare provider will typically diagnose an earache by performing a physical examination and asking questions about the patient's symptoms and medical history. They may also use diagnostic tests such as otoscopy (examination of the ear canal with a special instrument), tympanometry (measuring the movement of the eardrum), or hearing tests to confirm the diagnosis.

Earache Treatment

Treatment for an earache will depend on the underlying cause, but may include:

* Antibiotics for bacterial infections
* Pain relief medication such as acetaminophen or ibuprofen
* Decongestants and antihistamines for allergies
* Eardrops to relieve pain and reduce inflammation
* Tubes inserted into the ear drum to drain fluid (in cases of otitis media with effusion)
* Surgery to remove any blockages or repair any damage to the middle ear bones.

Earache Prevention

Preventing earaches is not always possible, but there are some steps you can take to reduce your risk:

* Keep your ears clean and dry
* Avoid inserting objects into your ears
* Avoid exposure to loud noises
* Get vaccinated against flu and other infections that can cause ear infections
* Practice good hygiene, such as washing your hands frequently.

Earache Home Remedies

There are several home remedies that may help relieve the pain of an earache:

* Applying a warm compress to the affected ear
* Using over-the-counter pain relief medication such as acetaminophen or ibuprofen
* Trying relaxation techniques such as deep breathing or meditation
* Gargling with salt water
* Using ear drops containing an anesthetic or anti-inflammatory agent.

Earache Prognosis

The prognosis for an earache depends on the underlying cause of the pain. In most cases, earaches are not a serious condition and can be effectively treated with over-the-counter medication and home remedies. However, if the earache is caused by a more serious condition such as otitis media, the prognosis may be poorer and may require antibiotics or other medical treatment.

Earache Complications

If left untreated, an earache can lead to several complications, including:

* Infection of the middle ear (otitis media)
* Spread of infection to other parts of the head and neck
* Hearing loss or impairment
* Balance problems
* Meningitis or sepsis.

Earache Prevalence

Earaches are a common condition that affects people of all ages, but they are most prevalent in children. According to the American Academy of Pediatrics, otitis media is the most common reason for antibiotic use in children under the age of 12.

Earache Epidemiology

Earaches are more common in certain populations, such as:

* Children under the age of 12
* People with a history of ear infections or allergies
* Those with a weakened immune system
* Smokers or people exposed to secondhand smoke.

Earache Incidence

The incidence of earaches varies depending on the population and the underlying cause. According to the Centers for Disease Control and Prevention (CDC), otitis media is the most common cause of ear infections, accounting for 80% of all cases. The incidence of otitis media peaks in children under the age of 2 and again in children between the ages of 5 and 14.

Earache Causes

Earaches can be caused by a variety of factors, including:

* Viral or bacterial infections of the middle ear
* Allergies
* Eustachian tube dysfunction
* Trauma to the head or ear
* Foreign objects inserted into the ear canal.

Earache Symptoms

The symptoms of an earache can vary depending on the underlying cause, but common symptoms include:

* Pain or discomfort in one or both ears
* Fever
* Discharge or fluid leaking from the ear
* Redness or swelling of the ear canal or eardrum
* Hearing loss or muffled hearing
* Vertigo or dizziness.

Earache Diagnosis

Diagnosing an earache typically involves a physical examination and a review of the patient's medical history. A healthcare provider may also use diagnostic tests such as a tympanometry, which measures the movement of the eardrum, or a CT scan or MRI, which can help identify any underlying structural abnormalities.

Earache Treatment

The treatment for an earache depends on the underlying cause and may include:

* Antibiotics to treat bacterial infections
* Pain relief medication such as acetaminophen or ibuprofen
* Eardrops to help relieve pain and reduce inflammation
* Decongestants to help relieve congestion
* Antihistamines to help relieve allergies.

Preventing Earaches

There are several steps that can be taken to prevent earaches, including:

* Practicing good hygiene, such as washing hands regularly and avoiding close contact with people who are sick
* Avoiding exposure to loud noises or sounds
* Using earplugs or earmuffs when necessary
* Avoiding insertion of objects into the ear canal
* Keeping the head and ears dry in wet environments
* Getting regular check-ups with a healthcare provider.

Earache Home Remedies

There are several home remedies that may help relieve an earache, including:

* Applying a warm compress to the affected ear
* Using eardrops containing garlic oil or tea tree oil
* Gargling with salt water
* Inhaling steam from a bowl of hot water
* Chewing on a piece of ginger.

Earache Complications

If left untreated, an earache can lead to several complications, including:

* Mastoiditis, an infection of the bones behind the eardrum
* Meningitis, an infection of the membranes that cover the brain and spinal cord
* Labyrinthitis, an inner ear infection that causes vertigo and balance problems.

Earache Diagnosis

To diagnose an earache, a healthcare provider will typically:

* Ask questions about the patient's symptoms and medical history
* Examine the patient's ears with an otoscope to look for signs of infection or other abnormalities
* Use a tuning fork to test hearing loss
* Order additional tests, such as a tympanometry or CT scan, if necessary.

Earache Treatment

Treatment for an earache will depend on the underlying cause, but may include:

* Antibiotics to treat bacterial infections
* Pain relief medication, such as acetaminophen or ibuprofen
* Eardrops to relieve pain and reduce inflammation
* In some cases, surgery may be necessary to drain abscesses or remove infected tissue.

In conclusion, an earache is a common condition that can be caused by a variety of factors. It is important to seek medical attention if symptoms persist or worsen over time. A healthcare provider will perform a thorough examination and order appropriate tests to determine the underlying cause and provide appropriate treatment. With proper diagnosis and treatment, most earaches can be effectively managed and resolved.

Examples of CAIs include:

1. Respiratory infections such as bronchitis, pneumonia, and influenza.
2. Skin and soft tissue infections such as cellulitis, abscesses, and wound infections.
3. Gastrointestinal infections such as food poisoning, diarrhea, and gastroenteritis.
4. Urinary tract infections (UTIs) caused by bacteria that enter the urinary tract through the urethra or bladder.
5. Sexually transmitted infections (STIs) such as chlamydia, gonorrhea, and syphilis.
6. Bacterial infections such as staphylococcus aureus, streptococcus pneumoniae, and haemophilus influenzae.
7. Viral infections such as herpes simplex virus (HSV), human papillomavirus (HPV), and norovirus.

CAIs can be treated with antibiotics, antivirals, or other medications depending on the cause of the infection. It's important to seek medical attention if symptoms persist or worsen over time, as untreated CAIs can lead to serious complications and potentially life-threatening conditions.

The most common bacteria that cause pneumonia are Streptococcus pneumoniae (also known as pneumococcus), Haemophilus influenzae, and Staphylococcus aureus. These bacteria can infect the lungs through various routes, including respiratory droplets, contaminated food or water, or direct contact with an infected person.

Symptoms of pneumonia may include cough, fever, chills, shortness of breath, and chest pain. In severe cases, pneumonia can lead to serious complications such as respiratory failure, sepsis, and death.

Diagnosis of pneumonia typically involves a physical examination, medical history, and diagnostic tests such as chest X-rays or blood cultures. Treatment typically involves antibiotics to eliminate the infection, as well as supportive care to manage symptoms and prevent complications. Vaccines are also available to protect against certain types of bacterial pneumonia, particularly in children and older adults.

Preventative measures for bacterial pneumonia include:

* Getting vaccinated against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib)
* Practicing good hygiene, such as washing hands regularly and covering the mouth and nose when coughing or sneezing
* Avoiding close contact with people who are sick
* Staying hydrated and getting enough rest
* Quitting smoking, if applicable
* Managing underlying medical conditions, such as diabetes or heart disease

It is important to seek medical attention promptly if symptoms of pneumonia develop, particularly in high-risk populations. Early diagnosis and treatment can help prevent serious complications and improve outcomes for patients with bacterial pneumonia.

Otitis can be caused by a variety of factors, including bacterial or viral infections, allergies, and exposure to loud noises. Symptoms may include ear pain, fever, difficulty hearing, and discharge or fluid buildup in the ear canal.

There are several types of otitis, including:

1. Otitis externa: Inflammation of the outer ear canal, often caused by bacterial or fungal infections.
2. Otitis media: Inflammation of the middle ear, often caused by bacterial or viral infections.
3. Suppurative otitis media: A severe form of otitis media that is characterized by the formation of pus in the middle ear.
4. Tubotympanic otitis media: Inflammation of the middle ear and mastoid bone, often caused by bacterial or viral infections.
5. Otitis media with effusion: A condition in which fluid accumulates in the middle ear without signs of infection.

Treatment for otitis depends on the type and severity of the inflammation or infection, but may include antibiotics, ear drops, or other medications to relieve symptoms. In severe cases, surgery may be necessary to drain fluid or remove infected tissue.

Symptoms of pharyngitis may include sore throat, fever, difficulty swallowing, and tender lymph nodes in the neck. Treatment typically involves antibiotics for bacterial infections, anti-inflammatory medications to reduce swelling and pain, and plenty of rest and fluids to help the body recover.

Pharyngitis is a common condition that affects people of all ages and can be caused by various factors, such as:

1. Viral infections: The most common cause of pharyngitis is a viral infection, such as the common cold or influenza.
2. Bacterial infections: Strep throat, which is caused by the bacterium Streptococcus pyogenes, is a type of bacterial infection that can cause pharyngitis.
3. Allergies: Allergies to pollens, dust mites, or other substances can cause postnasal drip and irritation of the throat, leading to pharyngitis.
4. Irritants: Exposure to smoke, chemicals, or other irritants can cause inflammation and soreness in the throat.
5. Dry air: Dry air can cause the throat to become dry and irritated, leading to pharyngitis.
6. Hormonal changes: Hormonal fluctuations during pregnancy or menstruation can cause changes in the throat that lead to pharyngitis.
7. Gastroesophageal reflux disease (GERD): GERD can cause stomach acid to flow up into the throat, leading to inflammation and soreness.
8. Sinus infections: Sinus infections can cause postnasal drip and irritation of the throat, leading to pharyngitis.
9. Mononucleosis: Mononucleosis, also known as mono, is a viral infection that can cause pharyngitis.
10. Other medical conditions: Certain medical conditions, such as rheumatoid arthritis or systemic lupus erythematosus, can cause pharyngitis.

It's important to note that a sore throat can be a symptom of a more serious underlying condition, so if you have a persistent or severe sore throat, you should see a healthcare professional for proper diagnosis and treatment.

Some common examples of nasopharyngeal diseases include:

1. Nasopharyngitis: This is an inflammation of the nasopharynx, often caused by viral infections such as the common cold.
2. Acute sinusitis: This is an infection of the sinuses, which are air-filled cavities in the skull, that can cause pain and swelling in the face and head.
3. Chronic nasopharyngitis: This is a long-term inflammation of the nasopharynx, often caused by allergies or exposure to irritants such as smoke.
4. Nasopharyngeal cancer: This is a type of cancer that affects the cells of the nasopharynx, and can be caused by viruses such as human papillomavirus (HPV).
5. Nasopharyngeal polyp: This is a growth of abnormal tissue in the nasopharynx, which can block the flow of air and cause breathing problems.
6. Nasopharyngeal stenosis: This is a narrowing of the nasopharynx, which can be caused by a variety of factors such as previous surgery or radiation therapy.
7. Turbinate hypertrophy: This is an enlargement of the turbinate bones in the nasopharynx, which can cause breathing problems and nasal congestion.
8. Nasopharyngeal cysts: These are fluid-filled sacs that can form in the nasopharynx, often caused by viral infections or allergies.
9. Nasopharyngeal meningitis: This is an inflammation of the meninges, the protective membranes covering the brain and spinal cord, which can cause fever, headache, and neck stiffness.
10. Nasopharyngeal abscess: This is a collection of pus in the nasopharynx, often caused by bacterial infections such as Staphylococcus aureus or Streptococcus pneumoniae.

These are just some of the possible causes of breathing difficulty through the nose, and it is important to consult a healthcare professional for an accurate diagnosis and appropriate treatment.

Symptoms of otitis media, suppurativa may include:

* Ear pain or discomfort
* Fever
* Discharge of pus or fluid from the ear
* Redness and swelling of the eardrum
* Hearing loss or muffled hearing
* Vertigo or dizziness

Treatment of otitis media, suppurativa usually involves antibiotics to clear the infection, as well as pain management with over-the-counter medications such as acetaminophen or ibuprofen. In severe cases, surgical drainage of the middle ear may be necessary.

Prevention of otitis media, suppurativa includes practicing good hygiene, avoiding close contact with people who are sick, and keeping the head and ears dry. Vaccination against certain types of bacteria that can cause this condition, such as Haemophilus influenzae type b (Hib), may also be recommended.

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  • Amoxicillin is in a class of medications called penicillin-like antibiotics. (medlineplus.gov)
  • Amoxicillin chemically is D-(-)a-amino-p-hydroxybenzyl penicillin trihydrate. (medi-vet.com)
  • The use of amoxicillin is contraindicated in animals with a history of an allergic reaction to penicillin. (medi-vet.com)
  • Amoxicillin is a semisynthetic penicillin and, therefore, has the potential for producing allergic reactions. (medi-vet.com)
  • We conducted a nationwide retrospective study in Japan to evaluate the effectiveness of oral amoxicillin or ampicillin as alternatives to injectable benzathine penicillin G for treating pregnant women with syphilis and preventing congenital syphilis (CS). (cdc.gov)
  • Amoxicillin belongs to a group of antibiotics known as penicillin, and is used to treat a wide range of infections caused by bacteria, including infections of the chest (pneumonia), middle ear (otitis media), sinuses (sinusitis), tonsils (tonsillitis), urinary tract, and skin and soft tissue. (sgh.com.sg)
  • Penicillin such as amoxicillin or amoxicillin-clavulanate may be used to complete the course if the strain is susceptible. (medscape.com)
  • Allergy to Amoxicillin or to any other penicillin antibiotic. (popularpills-au.com)
  • But the emergence and the development of resistance of bac- (ii) Penicillin, amoxicillin, ceftriaxone, cefotaxime, cefpo- teria of the most frequent pathogen of respiratory tract to doxime, erythromycin, levofloxacin, and chlorampheni- commonly prescribed antibiotics is a real problem for public col for S. pyogenes . (who.int)
  • Amoxicillin and ceftriaxone as treatment alternatives to penicillin for maternal syphilis. (bvsalud.org)
  • Antibiotics such as amoxicillin will not work for colds, flu, and other viral infections. (medlineplus.gov)
  • If you stop taking amoxicillin too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • Fortunately, several alternative antibiotics can be substituted for amoxicillin. (arrivehealth.com)
  • When susceptibility test results show susceptibility to amoxicillin, indicating no beta-lactamase production, Amoxicillin and Clavulanate Potassium for Oral Suspension should not be used. (nih.gov)
  • Most strains of the following gram-positive and gram-negative bacteria have demonstrated susceptibility to amoxicillin, both in vitro and in vivo nonpenicillinase-producing staphylococci, alpha- and beta-hemolytic streptococci, Streptococcus faecalis, Escherichia coli and Proteus mirabilis. (medi-vet.com)
  • Biomox Tablets (amoxicillin) is a broad-spectrum, semi-synthetic antibiotic which provides bactericidal activity against a wide range of common gram-positive and gram-negative pathogens. (medi-vet.com)
  • Amoxicillin 250mg is a generic antibiotic used to treat various bacterial infections. (pharmarun.africa)
  • However, if the bacteria spreads and becomes debilitating, amoxicillin is often the medication of choice since the common strains that thrive in these cavities are susceptible to this antibiotic. (safetymedical.net)
  • These highlights do not include all the information needed to use Amoxicillin and Clavulanate Potassium for Oral Suspension safely and effectively. (nih.gov)
  • See full prescribing information for Amoxicillin and Clavulanate Potassium for Oral Suspension. (nih.gov)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of Amoxicillin and Clavulanate Potassium for Oral Suspension and other antibacterial drugs, Amoxicillin and Clavulanate Potassium for Oral Suspension should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • History of cholestatic jaundice/hepatic dysfunction associated with amoxicillin and clavulanate potassium for oral suspension. (nih.gov)
  • Serious (including fatal) hypersensitivity reactions: Discontinue amoxicillin and clavulanate potassium for oral suspension if a reaction occurs. (nih.gov)
  • Patients with mononucleosis who receive amoxicillin and clavulanate potassium for oral suspension develop skin rash. (nih.gov)
  • Avoid amoxicillin and clavulanate potassium use in these patients. (nih.gov)
  • Concomitant use of amoxicillin and clavulanate potassium for oral suspension and oral anticoagulants may increase the prolongation of prothrombin time. (nih.gov)
  • Amoxicillin and clavulanate potassium for oral suspension may reduce efficacy of oral contraceptives. (nih.gov)
  • Each dose (4 capsules) of Talicia includes rifabutin 50 mg, amoxicillin 1,000 mg and omeprazole 40 mg. (medicinenet.com)
  • or any of the ingredients in amoxicillin capsules, tablets, or suspension. (medlineplus.gov)
  • The organization posted a bulletin listing the affected products, which include various amoxicillin oral powders for suspension, tablets and capsules. (arrivehealth.com)
  • Amoxicillin and Bromhexine Capsules is a combination medicine that is prescribed to treat various types of respiratory infections. (kdiamexim.com)
  • or unrelated concerns such as ear infections that are appropriately treated with amoxicillin. (arrivehealth.com)
  • Amoxicillin gentamicin use their infections free do not any an organization as echo, launched in endocarditis. (leap4fnssa.eu)
  • Another issue is that there has reportedly been an increase in RSV Infections across the country and Amoxicillin is commonly used to treat infections that are linked to that. (hudsonvalleypost.com)
  • and 100% were sensitive to levofloxacin, isolates have been included in the study: 94 S. pyogenes chloramphenicol, amoxicillin, cefotaxime, and ceftriaxone. (who.int)
  • 100% were sensitive to levofloxacin, cefotaxime amoxicillin, and ceftriaxone. (who.int)
  • Its mechanism of action is anti-bacterial and consists in inhibition of construction of bacteria cell walls sensitive to Amoxicillin. (popularpills-au.com)
  • Cell walls serve to protect bacteria from environment and action of Amoxicillin prevents their propagation. (popularpills-au.com)
  • Amoxicillin comes as a capsule, a tablet, a chewable tablet, and as a suspension (liquid) to take by mouth. (medlineplus.gov)
  • Amoxicillin has been added to the drug shortage list, specifically in liquid form. (petitenp.com)
  • A shortage in some formulations of amoxicillin commonly used for children that emerged this fall is largely driven by increased demand during an early and prolific season for respiratory illnesses , according to the FDA and several manufacturers of the medication. (arrivehealth.com)
  • Samuel L. Aitken, PharmD, MPH, BCIDP, a clinical pharmacist specialist in infectious diseases at Michigan Medicine, in Ann Arbor, told Pharmacy Practice News he is concerned that the shortage may be caused in part by amoxicillin being overprescribed for viral illnesses. (arrivehealth.com)
  • To deal with the shortage, some manufacturers have implemented limits on how much amoxicillin pharmacies can purchase at a given time, according to the FDA and ASHP bulletins. (arrivehealth.com)
  • Unfortunately, there could potentially be a medication shortage and Amoxicillin is included on the list. (hudsonvalleypost.com)
  • Why could there be an Amoxicillin shortage? (hudsonvalleypost.com)
  • if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), you should know that some amoxicillin chewable tablets are sweetened with aspartame that forms phenylalanine. (medlineplus.gov)
  • Until adequate reproductive studies are accomplished, Biomox (amoxicillin) tablets should not be used in pregnant or breeding animals. (medi-vet.com)
  • Biomox (amoxicillin) tablets are supplied in 50 mg, 100 mg and 200 mg concentrations in bottles of 500 and 1000 tablets. (medi-vet.com)
  • If you become pregnant while taking amoxicillin, call your doctor. (medlineplus.gov)
  • We investigated 80 pregnant women with active syphilis treated with amoxicillin or ampicillin during 2010-2018. (cdc.gov)
  • We found oral amoxicillin potentially ineffective for preventing CS cases among pregnant women with late syphilis but potentially effective in those with early syphilis. (cdc.gov)
  • Prospective studies are needed to definitively evaluate the efficacy of amoxicillin for the treatment of pregnant women with syphilis to prevent CS. (cdc.gov)
  • Because sales of BPG stopped in Japan in 1986, oral penicillins, such as amoxicillin or ampicillin, have been primarily used to treat pregnant women with syphilis. (cdc.gov)
  • Individuals who are pregnant or breastfeeding can use amoxicillin. (medscape.com)
  • The downstream consequence of this, assuming the bad RSV season continues throughout the winter potentially alongside influenza and COVID, is that amoxicillin supplies may run dry and we won't have it available when it is truly needed. (arrivehealth.com)
  • Amoxicillin has bactericidal activity against susceptible organisms similar to that of ampicillin. (medi-vet.com)
  • Symptoms of Amoxicillin overdose may be vomiting, nausea, diarrhea, disorders of water and electrolytes balance. (popularpills-au.com)
  • amiloride oral decreases levels of amoxicillin oral by reducing drug absorption from the stomach and intestine into the body when taken by mouth. (rxlist.com)
  • amiloride oral decreases levels of amoxicillin oral by inhibition of GI absorption. (rxlist.com)
  • Amoxicillin is not known to decrease effect of birth control pills, increases absorption of digoxin, increases toxicity of metotrexat. (popularpills-au.com)
  • Community case management of fast-breathing pneumonia with 3 days oral amoxicillin vs 5 days cotrimoxazole in children 2-59 months of age in rural Pakistan: A cluster randomized trial. (bvsalud.org)
  • Treatment recommendation by the World Health Organization ( WHO ) for fast- breathing pneumonia includes oral amoxicillin and cotrimoxazole (as an alternative). (bvsalud.org)
  • Lady Health Workers (LHWs) were trained in assessing, classifying, and managing fast- breathing pneumonia cases ( Respiratory rate of >50 breaths/min) at home with oral amoxicillin for three days and with co-trimoxazole for five days in the intervention and control arms respectively. (bvsalud.org)
  • Antibiótico semisintético de amplio espectro, similar a la AMPICILINA excepto en que su resistencia al ácido gástrico permite más altas concentraciones séricas tras la administración por vía oral. (bvsalud.org)
  • It was concluded that after clinical intervention, the effectiveness of the use of amoxicillin in periods of 3 and 7 days was similar in the evaluated volunteers. (bvsalud.org)
  • If you breastfeed and take Amoxicillin, the medication may excrete in milk and cause diarrhea in your baby. (popularpills-au.com)
  • We haven't had to make any major changes, and most of our work has been preparation for potential issues down the road: making alternative recommendations in hospital guidelines in case we do begin to run out of amoxicillin, identifying high-priority areas, finding alternative suppliers and giving recommendations to our physicians and other providers for alternatives in case a pharmacy is not able to fill a prescription. (arrivehealth.com)
  • Cheapest drugs online - buy and save amoxicillin without prescriptin . (iamjoeamerica.com)
  • You should begin to feel better during the first few days of treatment with amoxicillin. (medlineplus.gov)
  • The aim of this study was to compare the use of amoxicillin for different time intervals (3 and 7 days) for treatment of acute dentoalveolar abscesses after performing drainage. (bvsalud.org)
  • G2 - The volunteers received 1g of amoxicillin before the drainage procedure, and 500mg of amoxicillin every 8 hours for 7 days. (bvsalud.org)
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  • Pharmacists may need to call other pharmacies in their area when amoxicillin supplies run low, or work with prescribers to find an appropriate alternative treatment. (arrivehealth.com)
  • Both Amoxicillin and Co-amoxiclav/Amoxicillin-Clavulanate contain amoxicillin as the active ingredient. (sgh.com.sg)
  • This study shows that amoxicillin can be as effective as cotrimoxazole to treat fast- breathing pneumonia cases at the domiciliary level. (bvsalud.org)
  • I'd start to not feel well, I'd have to go to the doctor and she'd write me a prescription for Amoxicillin and then I'd instantly feel better. (hudsonvalleypost.com)
  • Officials also pointed out that there is still Amoxicillin available, but it might just require a change of prescription to get the medicine. (hudsonvalleypost.com)
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  • The drug interaction information described here is based on the prescribing information of individual Talicia components: omeprazole, amoxicillin, and rifabutin. (medicinenet.com)
  • But last month amoxicillin transactions climbed to 1.41%, accounting for 24.52% and 19.22% of the total transactions for children aged 0 to 2 years and 3 to 12 years, respectively. (arrivehealth.com)
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