Antimalarials
Sulfadoxine
Artemisinins
Pyrimethamine
Chloroquine
Drug Combinations
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Plasmodium falciparum
Drug Resistance
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Parasitic Sensitivity Tests
Senegal
Drug Therapy, Combination
Cameroon
Histamine N-Methyltransferase
Parasitemia
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Angola
Gabon
Burkina Faso
Chlorpheniramine
Mali
A country in western Africa, east of MAURITANIA and south of ALGERIA. Its capital is Bamako. From 1904-1920 it was known as Upper Senegal-Niger; prior to 1958, as French Sudan; 1958-1960 as the Sudanese Republic and 1959-1960 it joined Senegal in the Mali Federation. It became an independent republic in 1960.
Quinine
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Membrane Transport Proteins
Sierra Leone
Mefloquine
Proguanil
Treatment Failure
Tanzania
Chemistry Techniques, Analytical
Treatment Outcome
Dapsone
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Multidrug Resistance-Associated Proteins
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
Inhibitory Concentration 50
Rwanda
Kenya
Papua New Guinea
A country consisting of the eastern half of the island of New Guinea and adjacent islands, including New Britain, New Ireland, the Admiralty Islands, and New Hanover in the Bismarck Archipelago; Bougainville and Buka in the northern Solomon Islands; the D'Entrecasteaux and Trobriand Islands; Woodlark (Murua) Island; and the Louisiade Archipelago. It became independent on September 16, 1975. Formerly, the southern part was the Australian Territory of Papua, and the northern part was the UN Trust Territory of New Guinea, administered by Australia. They were administratively merged in 1949 and named Papua and New Guinea, and renamed Papua New Guinea in 1971.
Plasmodium vivax
Malaria, Vivax
Relationships between malaria prevalence and malaria-related morbidity in school children from two villages in central Africa. (1/318)
To investigate the relationship between parasite prevalence and malaria-related morbidity, we carried out a comparative study among cohorts of school children from two villages, Dienga, Gabon, and Pouma, Cameroon, both located in malaria-endemic areas. Seven to 17 year-old children attending primary schools were similarly followed-up at each site to evaluate the frequency of malaria attacks. Follow-up involved daily temperature recording (and blood smears in the case of fever) and preparation of blood smears every two weeks. In Pouma, 186 children were followed-up for six months. In Dienga, 228 children were followed-up for nine months. The mean prevalence rate of Plasmodium falciparum infections (as assessed by the blood smears) was twice as high in Pouma compared with Dienga (45.2% versus 26.8%; P < 0.0001), whereas the monthly malaria attack rate (as assessed by the daily surveillance) was twice as high in Dienga compared with Pouma (21.5% versus 41.4%; P = 0.003). The possible implication of several parameters that may differ between the two areas, such as the malaria transmission level, the economical and social status of the inhabitants, the characteristics of infecting parasite strains, and the genetic background of the population, is discussed. (+info)Analysis of mefloquine resistance and amplification of pfmdr1 in multidrug-resistant Plasmodium falciparum isolates from Thailand. (2/318)
Resistance to quinoline-containing compound has been associated with the Plasmodium falciparum multidrug resistance 1 (pfmdr1) gene. We analyzed wild P. falciparum isolates with high levels of chloroquine and mefloquine resistance for their macrorestriction maps of chromosome 5 and sequence of pfmdr1. Two types of chromosome 5 amplification were found. Eleven of 62 resistant isolates displayed Bgl 1 fragments larger than 100 kb. Twenty-nine isolates possessed multiple copies of the fragments. We failed to detect any amplification of this region on chromosome 5 in 22 mefloquine-resistant isolates, suggesting that other mechanisms can mediate the mefloquine-resistant phenotype. There was no direct association between pfmdr1 mutations and chloroquine sensitivity. Resistant lines could have Asn-86 and Tyr-184 or Phe-184, the predicted sequence of those chloroquine-sensitive isolates. No mutation at Asn-1042 and Asp-1246 was detected among these chloroquine-resistant isolates. Therefore, a few base substitutions in the pfmdr1 gene may not be sufficient to account for all chloroquine-resistant phenotypes. (+info)Factors influencing resistance to reinfection with Plasmodium falciparum. (3/318)
A treatment-reinfection study design was used to investigate the relationships between host immunologic and/or genetic factors and resistance to reinfection with Plasmodium falciparum. Sixty-one children in Gabon were enrolled in a cross-sectional study to measure the prevalence of each human plasmodial species. All were given amodiaquine for radical cure of parasites, and 40 were subsequently followed-up for 30 weeks. Successive blood smears were examined to measure the delay of reappearance in blood of asexual stages of P. falciparum parasites. Presence of infection during the cross-sectional survey was associated with male sex, non-deficient glucose-6-phosphate dehydrogenase activity, plasma interleukin-10 level, and anti-LSA-Rep antibody concentration. Resistance to reinfection was related to the presence of anti-LSA-J antibodies, and the absence of anti-LSA-Rep antibodies. Moreover, P. malariae-infected subjects were usually co-infected with P. falciparum, and were also more rapidly reinfected with P. falciparum after treatment, compared with those without P. malariae infection. (+info)Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates. (4/318)
The in vitro activities of doxycycline, chloroquine, quinine, amodiaquine, artemether, pyrimethamine, and cycloguanil were evaluated against Plasmodium falciparum isolates from Senegal (Dielmo and Ndiop), using an isotopic, micro, drug susceptibility test. The 71-50% inhibitory concentration (IC50) values for doxycycline ranged from 0.7 to 108.0 microM and the geometric mean IC50 for the 71 isolates was 11.3 microM (95% confidence interval = 9.5-13.4 microM). The activity of doxycycline did not differ significantly (P = 0.0858) between the chloroquine-susceptible isolates and the chloroquine-resistant isolates. There was no in vitro correlation between the responses to doxycycline and those to artemether, chloroquine, quinine, amodiaquine, pyrimethamine, and cycloguanil, suggesting no in vitro cross-resistance among these drugs. Potency was increased by prolonged exposure. In 96-hr incubations, the activity of doxycycline was 4-5-fold more increased than in 48-hr incubations. The in vitro activity of doxycycline against intraerythrocytic stages of multidrug-resistant P. falciparum, its action against the preerythrocytic forms, the lack of correlation between the responses in vitro of P. falciparum to doxycycline and the other antimalarial drugs, and its original potential site of action are factors that favor its use as antimalarial drug. (+info)In vivo efficacy study of amodiaquine and sulfadoxine/ pyrimethamine in Kibwezi, Kenya and Kigoma, Tanzania. (5/318)
We conducted two randomized clinical trials to determine the in vivo efficacy of amodiaquine and sulfadoxine/pyrimethamine in treating Plasmodium falciparum malaria. Seventy-five patients under the age of 10 years in Kibwezi, Kenya, and 171 patients in Kigoma, Tanzania, were enrolled for treatment. Due to loss of eight patients in Kibwezi and 37 in Kigoma to follow-up, we used best and worst case scenarios for the parasitological response. The in vivo sensitivity of Plasmodium falciparum to amodiaquine was 75% (no loss to follow-up) in Kibwezi and ranged from 85% in the best to 65% in the worst case scenario in Kigoma. The sensitivity to sulfadoxine/pyrimethamine was 70% to 88% in Kibwezi and 65% to 89% in Kigoma. R1 resistance to amodiaquine was 22% in Kibwezi and varied from 6% in the best to 26% for the worst case scenario in Kigoma. The R1 resistance to sulfadoxine/pyrimethamine was 5% to 23% in Kibwezi and 2% to 26% in Kigoma. R2 resistance was 3% for amodiaquine and 7% for sulfadoxine/pyrimethamine in Kibwezi and 9% in Kigoma for each treatment group. There was no statistically significant difference between treatment groups at either study site, except for a slight difference in R1 resistance in the best case scenario, Kibwezi, in favour of S/P. Although both amodiaquine and sulfadoxine/pyrimethamine resistance seems to be increasing, these antimalarials are still effective in parasite clearance. (+info)Adaptation of a chloroquine-resistant strain of Plasmodium vivax from Indonesia to New World monkeys. (6/318)
The spread of chloroquine-resistant Plasmodium vivax from Papua New Guinea and Indonesia poses a serious health threat to areas of Southeast Asia where this species of malaria parasite is endemic. A strain of P. vivax from Indonesia was adapted to develop in splenectomized Aotus lemurinus griseimembra, Aotus vociferans, Aotus nancymai, and Saimiri boliviensis monkeys. Transmission to splenectomized Saimiri monkeys was obtained via sporozoites. Chemotherapeutic studies indicated that the strain was resistant to chloroquine and amodiaquine while sensitive to mefloquine. Infections of chloroquine-resistant P.vivax in New World monkeys should be useful for the development of alternative treatments. (+info)Role of extraneuronal mechanisms in the termination of contractile responses to amines in vascular tissue. (7/318)
1 The role of the uptake and release of agonist from extraneuronal sites in the termination of responses of rabbit aortic strips to amines was studied. 2 Strips were contracted with adrenaline or noradrenaline and after response plateau was reached, the muscle chambers were washed free of agonist and the relaxation in Krebs solution recorded. After inhibition of catechol-O-methyl-transferase, monoamine oxidase and neuronal uptake the relaxation rate was greatly prolonged. Evidence is provided that this very slow relaxation resulted from the accumulation of intact amine at extraneuronal sites during exposure to the agonist and its subsequent release past receptors due to a reversal of the concentration gradient after washout. 3 Pretreatment with the haloalkylamine, GD-131 (N-cyclohexylmethyl-N-ethyl-beta-chloroethylamine), an inhibitor of extraneuronal uptake, returned the slow relaxation rate after enzyme inhibition towards that of control strips. By blocking the extraneuronal transport of amines their accumulation at intracellular loci after enzyme inhibition was prevented. 4 The effects of GD-131 and 17beta-oestradiol on the relaxation rate of untreated strips contracted by adrenaline and noradrenaline confirmed that extraneuronal uptake to sites of enzymatic activity is the major mechanism terminating their action. 5 Inactivation of extraneuronal transport sites by GD-131 was prevented by protecting them with 17beta-oestradiol or normetanephrine during exposure to the haloalkylamine, pointing to a common site of action of these agents on a specific carrier system for amines. 6 Evidence is presented that the relaxation from contractions induced by histamine and 5-hydroxytryptamine also involves extraneuronal accumulation and release, probably by an uptake process which is identical to the one for catecholamines. (+info)"One-pot" synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline. (8/318)
Amodiaquine (AQ) is an antimalarial which is effective against chloroquino-resistant strains of Plasmodium falciparum but whose clinical use is severely restricted because of associated hepatotoxicity and agranulocytosis. "One-pot" synthesis of formamidines likely to be transformed into AQ derivatives is reported. Compared with AQ, the new compounds were devoid of in vitro cytotoxicity upon human embryonic lung cells and mouse peritoneal macrophages. One showed a potent in vivo activity in mice infected with P berghei. Transformation of this compound by reductive amination led to a new type of AQ derivatives that displayed an in vitro activity similar to that of AQ but did not lead to toxic quinone-imines. (+info)
The American Journal of Tropical Medicine and Hygiene | A Comparison of the in Vitro Activities of Amodiaquine and...
Amodiaquine resistance in Plasmodium falciparum malaria is associated with the pfcrt 72-76 SVMNT allele in Afghanistan. -...
Biomedicines | Free Full-Text | In Vivo Efficacy of Artesunate/Sulphadoxine-Pyrimethamine versus Artesunate/Amodiaquine in the...
ATAQ EASY: Artesunate + Amodiaquine Fixed Dose Combination in the Treatment of Uncomplicated Plasmodium Falciparum Malaria -...
Amodiaquine for treating malaria. - GOV.UK
Compliance, Safety, and Effectiveness of Fixed-Dose Artesunate-Amodiaquine for Presumptive Treatment of Non-Severe Malaria in...
DSpace at EWHA: Enhanced CD25+Foxp3+ regulatory T cell development by amodiaquine through activation of nuclear receptor 4A
Amodiaquine Suspension Manufacturer, Supplier in Vadodara,Gujarat
IPTC Standard - IPTC
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta...
Clinical Reviews and Opinions - impact of seasonal malaria chemoprevention of sulphadoxine-pyrimethamine plus amodiaquine on...
Artesunate-amodiaquine for the treatment of uncomplicated malaria. - GOV.UK
Product Directory on Drugdu.com for Artemether and Lumefantrine Tablets|||269315|||astra-lifecare-india-pvt, Amodiaquine HCl...
Bidirectional and gene-selective Nurr1 modulation by NSAIDs? | Nature Research Chemistry Community
Life with Leukaemia: Malaria Eradication
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Impact of treatment and re-treatment with artemether-lumefantrine and artesunate-amodiaquine on selection of Plasmodium...
Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine...
Monitoring of efficacy, tolerability and safety of artemether-lumefantrine and artesunate-amodiaquine for the treatment of...
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Pharmacokinetics of Artemether-Lumefantrine and Artesunate-Amodiaquine in Children in Kampala, Uganda | Antimicrobial Agents...
Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in...
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Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a...
Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria...
Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and...
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Challenges to replace ACT as first-line drug | Malaria Journal | Full Text
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The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review |...
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Fournisseur/ Contractant
AQ Bio Santizer Refill-Machine Purpose (MR2500)
lib/Parse/AFP/Triplet/AQ.pm - metacpan.org
Follistim AQ Dosage Guide - Drugs.com
In the town of Djibo in northern Burkina Faso, a Fulani child is sick with malaria. After a visit to the local military health...
Most recent papers with the keyword Dihydroartemisinin | Read by QxMD
Seasonal malaria chemoprevention: successes and missed opportunities | Epicentre
The outcome of a test-treat package versus routine outpatient care for Ghanaian children with fever: a pragmatic randomized...
Amodiaquine-lnduced HepatitisA Report of Seven Cases | Annals of Internal Medicine | American College of Physicians
Treating malaria with artemisinin combinations: challenges for policymakers
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Amodiaquine
... is a 4-aminoquinoline compound related to chloroquine. Amodiaquine was first made in 1948. It is on the World ... "Amodiaquine". Drug Information Portal. U.S. National Library of Medicine. Scholia has a topic profile for Amodiaquine. Portal: ... Amodiaquine has become an important drug in the combination therapy for malaria treatment in Africa. It is often used in ... Amodiaquine has also been found to work against chloroquine-resistant P. falciparum strains of malaria. It is also used in ...
Montelukast
"Artesunate Amodiaquine Winthrop (artesunate, amodiaquine) , summary of product characteristics. Gentilly, France: Sanofi- ... Therefore, it is theoretically possible that the combination of montelukast with a CYP2C8 substrate (e.g. amodiaquine, an anti- ... March 2007). "Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz". Clin. Infect. Dis. ...
4-Aminoquinoline
Examples include amodiaquine, chloroquine, and hydroxychloroquine. Other uses for the derivatives are: anti-asthmatic, ... Amodiaquine Chloroquine Hydroxychloroquine Quinoline 8-Hydroxyquinoline Ionophore Al-Ahmary, Khairia M.; Alenezi, Maha S.; ... insights from the study of amodiaquine uptake". Mol. Pharmacol. 50 (6): 1551-8. PMID 8967977. DeVita, Robert; Chang, Lehua (13 ...
Drugs for Neglected Diseases Initiative
"Treating uncomplicated malaria with ASAQ (artesunate-amodiaquine) , Medicines for Malaria Venture". www.mmv.org. Retrieved 2022 ... Lacaze Catherine (2011). "The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the ... this antimalarial product is a fixed-dose combination of artesunate/amodiaquine (ASAQ). The result of a partnership between ...
Artesunate
"Artesunate Amodiaquine Winthrop (artesunate, amodiaquine) [summary of product characteristics]" (PDF). Sanofi-Aventis. Archived ... evidence that treatment with artesunate plus mefloquine is superior to treatment with artesunate plus amodiaquine or artesunate ...
Malaria
Amodiaquine plus sulfadoxine-pyrimethamine may achieve less treatment failures when compared to sulfadoxine-pyrimethamine alone ... Sulfadoxine-pyrimethamine plus artesunate is better than sulfadoxine-pyrimethamine plus amodiaquine in controlling treatment ... Cochrane Infectious Diseases Group) (October 2005). "Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for ... "Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated malaria ...
WHO Model List of Essential Medicines
Artesunate Artesunate/amodiaquine (artesunate + amodiaquine) Artesunate/mefloquine (artesunate + mefloquine) Artesunate/ ... To be used in combination with either amodiaquine, mefloquine or sulfadoxine + pyrimethamine. Other combinations that deliver ... Amodiaquine + sulfadoxine/pyrimethamine (Co-packaged) Chloroquine Doxycycline Mefloquine Proguanil Sulfadoxine/pyrimethamine ( ... α Diloxanide Metronidazole Amphotericin B Miltefosine Paromomycin Sodium stibogluconate or meglumine antimoniate Amodiaquine ...
WHO Model List of Essential Medicines for Children
To be used in combination with either amodiaquine, mefloquine or sulfadoxine + pyrimethamine. Other combinations that deliver ... Diloxanide Metronidazole Amphotericin B Miltefosine Paromomycin Sodium stibogluconate or meglumine antimoniate Amodiaquine ... Artemether Artemether/lumefantrine Artesunate Artesunate/amodiaquine Artesunate/mefloquine Artesunate/pyronaridine ... Dihydroartemisinin/piperaquine phosphate Doxycycline Mefloquine Primaquine Quinine Sulfadoxine/pyrimethamine Amodiaquine + ...
Quinoline
... amodiaquine, and primaquine. Quinolines are reduced to tetrahydroquinolines enantioselectively using several catalyst systems. ...
Mepacrine
Chloroquine Amodiaquine Pamaquine Mefloquine "Quinacrine Shortage & What the ACR Is Doing about It". 13 March 2019 [8 February ...
Selective sweep
"Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and ...
Mass drug administration
In Bobo-Dioulasso, where primaquine was used in combination with either chloroquine or amodiaquine, the prevalence of ... 1999). "[Assay of sensitivity of Plasmodium falciparum to chloroquine, amodiaquine, piperaquine, mefloquine and quinine in ...
Antimalarial medication
Amodiaquine is a 4-aminoquinolone anti-malarial drug similar in structure and mechanism of action to chloroquine. Amodiaquine ... Amodiaquine is now available in a combined formulation with artesunate (ASAQ) and is among the artemisinin-combination ... The resistance of other quinolone anti-malarials such as amodiaquine, mefloquine, halofantrine and quinine are thought to have ... Artemisinin-based combination therapies should be used in preference to amodiaquine plus sulfadoxine-pyrimethamine for the ...
Plasmodium falciparum
WHO recommends combinations such as artemether/lumefantrine, artesunate/amodiaquine, artesunate/mefloquine, artesunate/ ...
Intermittent preventive therapy
A trial conducted in northern Tanzania using the antimalarial drug amodiaquine instead of S/P was similarly successful. Six ... Effect of intermittent treatment with amodiaquine on anaemia and malarial fevers in infants in Tanzania: a randomised placebo- ... Treating schoolchildren in Kenya with S/P and amodiaquine significantly improved anaemia (RR 0.52, 95% CI 0.29-0.93). IPTp ...
Wyss Institute for Biologically Inspired Engineering
Use of computational approaches and organ-chips to repurpose FDA-approved drugs like Amodiaquine to prevent or treat Covid-19. ...
Histamine N-methyltransferase
The following substances are known to be HNMT inhibitors: amodiaquine, chloroquine, dimaprit, etoprine, metoprine, quinacrine, ...
Clerk family
Amodiaquine, or the Combination in Pregnant Women in Ghana". The Journal of Infectious Diseases. 198 (8): 1202-1211. doi: ...
Rajpal Singh Yadav
... amodiaquine, quinine, mefloquine and sulfadoxine/pyrimethamine in a tribal population of District Sundargarh, Orissa". Indian ...
4,7-Dichloroquinoline
... is a two-ring heterocyclic compound used as a chemical intermediate to aminoquinoline antimalarial drugs including amodiaquine ...
4-Aminophenol
Treating 4-aminophenol with acetic anhydride gives paracetamol: It is a precursor to amodiaquine, mesalazine, AM404, ...
R. Heiner Schirmer
"Efficacy and Safety of Triple Combination Therapy With Artesunate-Amodiaquine-Methylene Blue for Falciparum Malaria in Children ...
Institute for Tropical Medicine Tübingen
... amodiaquine artesunate, pyronaridine artesunate as well as malaria and ebola vaccines. According to a survey of the ...
Peter Gottfried Kremsner
He has been principal investigator on key studies for the development of atovaquone/proguanil, artesunate/amodiaquine, ...
Affordable Medicines Facility-malaria
... and amodiaquine (AQ), which usually cost less than US$1. Therefore, unsubsidized, quality-assured ACTs are not affordable by ...
Chemoprophylaxis
Malaria in the Sahel region of Sub-Saharan Africa through the use of the drugs sulfadoxine/pyrimethamine and amodiaquine. This ...
List of MeSH codes (D03)
... amodiaquine MeSH D03.438.810.050.180 - chloroquine MeSH D03.438.810.050.180.350 - hydroxychloroquine MeSH D03.438.810.050.440 ...
ATC code P01
... combinations P01BA01 Chloroquine P01BA02 Hydroxychloroquine P01BA03 Primaquine P01BA06 Amodiaquine P01BA07 Tafenoquine P01BB01 ... P01BE05 Artenimol P01BF01 Artemether and lumefantrine P01BF02 Artesunate and mefloquine P01BF03 Artesunate and amodiaquine ...
Artemisinin
... artesunate/amodiaquine (ASAQ), artesunate/mefloquine, dihydroartemisinin/piperaquine, or artesunate/sulfadoxine/pyrimethamine. ...
PATH (global health organization)
1.7 million doses of Sanofi's ArteSunate AmodiaQuine Winthrop (ASAQ Winthrop), a fixed-dose artemisinin-based combination ...
International Notes Agranulocytosis Associated with the
Use of Amodiaquine for Malaria Prophylaxis
... number of persons using amodiaquine for malaria prophylaxis. Although amodiaquine is not marketed in the United States, ... Editorial Note: Amodiaquine, a 4-aminoquinoline similar to chloroquine in structure and activity, has been used as both an ... In all but four of the 25 cases, amodiaquine was used at the appropriate dosage (adults 400 mg base per week) for prophylaxis. ... Only rarely has amodiaquine been associated with agranulocytosis: of 13 reports published between 1955 and 1985, only three ...
Amodiaquine : a case for reconsideration? : reports on individual drugs
Figure 1 - Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria...
Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, ... Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, ... units and 3 referral health facilities for which increased sensitivity of Plasmodium falciparum to artesunate/amodiaquine ...
Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria:...
Amodiaquine was the most effective on fever. Amodiaquine therapy selected molecular markers for chloroquine resistance, while ... The study demonstrated that sulphadoxine-pyrimethamine and amodiaquine were appropriate partner drugs that could be associated ... amodiaquine and sulphadoxine-pyrimethamine, respectively. After molecular correction, ACPRs (cACPR) were 63.2%, 88.5% and 98.0 ... amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria. During the malaria ...
Activation of CD8+ T Cells in the Context of Amodiaquine-Induced Liver Injury Advances Groundwork for Mathematical...
Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised,...
Six patients in the amodiaquine-artesunate group and five in the amodiaquine group developed early, drug-induced vomiting, ... By intention-to-treat analysis, the day-14 cure rates for amodiaquine-artesunate versus amodiaquine were: 175/192 (91%) versus ... Amodiaquine-artesunate is a potential combination for use in Africa. Further investigations to assess the potential effect on ... Amodiaquine still retains efficacy against P falciparum in many African countries. We assessed the safety, treatment efficacy, ...
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Pharmacokinetics of Amodiaquine and Desethylamodiaquine in Pregnant and Postpartum Women with Plasmodium vivax Malaria - MORU...
The results suggest that the current amodiaquine dosing regimen is adequate for the treatment of P. vivax infections during ... Plasma was analyzed for amodiaquine and desethylamodiaquine by use of a liquid chromatography-tandem mass spectrometry method. ... There were no clinically relevant differences in the pharmacokinetics of amodiaquine and desethylamodiaquine between pregnant ... malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days. The same women were studied again at 3 months ...
IMSEAR at SEARO: Amodiaquine as a filaricide.
Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment,...
Amodiaquine Antimalarials Artesunate Drug Combinations Drug Resistance Humans Malaria Malaria, Falciparum Plasmodium Falciparum ... Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, ... Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, ... Title : Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria ...
Evaluation of Azathioprine-Induced Cytotoxicity in an In Vitro Rat Hepatocyte System
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A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma - Centre for Tropical Medicine and...
A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma ... The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis ... A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma ... Triple therapy with artemether-lumefantrine plus amodiaquine versus artemether-lumefantrine alone for artemisinin-resistant, ...
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Artesunate Amodiaquine Tablets Exporter and Supplier,Trader from Surat,Gujarat
Trader and Exporter of Artesunate Amodiaquine Tablets located in Surat, Gujarat, India. ... Amodiaquine is an antimalarial medication used to treat acute malarial attacks characterized by symptoms such as chills, fever ... Combipack of Artesunate Tablets And Amodiaquine Hydrochloride Tablets. *Combikit of Sulfadoxine Pyrimethamine Tablets And ...
MEDBOX | Effect of Artesunate-Amodiaquine on Mortality Related to Ebola Vir...
Details for: A comparative study of amodiaquine and chloroquine in two test systems / › WHO HQ Library catalog
TextPublication details: 1984. Description: 108 leavesSubject(s): Antimalarials , Amodiaquine , Chloroquine , Dissertations, ... A comparative study of amodiaquine and chloroquine in two test systems / by Peter Oyem Olise. By: Olise, Peter OyemContributor( ... Details for: A comparative study of amodiaquine and chloroquine in two test systems / ...
High-performance liquid chromatographic analysis of amodiaquine in human plasma. - Experimental Medicine Division
Table 5 - Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria...
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Carbamazepine (Oral Route) Proper Use - Mayo Clinic
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. Do not take carbamazepine together with a monoamine oxidase inhibitor (MAOI) or during the first 14 days after you stop taking a MAOI. MAOIs are used for depression and some examples are isocarboxazid (Marplan®), phenelzine (Nardil®), procarbazine (Matulane®), selegiline (Eldepryl®), or tranylcypromine (Parnate®). Do not use this medicine together with nefazodone (Serzone®) and certain medicines for HIV/AIDS (such as delavirdine, efavirenz, Atripla®, Sustiva®, Rescriptor®). Carbamazepine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these unwanted effects, tell your ...
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Clinical tolerability of artesunate-amodiaquine versus comparator treatments for uncomplicated falciparum malaria: an...
BackgroundThe widespread use of artesunate-amodiaquine (ASAQ) for treating uncomplicated malaria makes it important to gather ... BackgroundThe widespread use of artesunate-amodiaquine (ASAQ) for treating uncomplicated malaria makes it important to gather ... Clinical tolerability of artesunate-amodiaquine versus comparator treatments for uncomplicated falciparum malaria: an ... Clinical tolerability of artesunate-amodiaquine versus comparator treatments for uncomplicated falciparum malaria: an ...
PDF) Plasmodium falciparum clearance in clinical studies of artesunate-amodiaquine and comparator treatments in sub-Saharan...
... trends and detect changes early enough to intervene Individual patient data from 27 clinical trials of artesunate-amodiaquine ( ... Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, ... Six patients in the amodiaquine-artesunate group and five in the amodiaquine group developed early, drug-induced vomiting, ... By intention-to-treat analysis, the day-14 cure rates for amodiaquine-artesunate versus amodiaquine were: 175/192 (91%) versus ...
ChloroquineMalariaArtesunateEfficacySulfadoxine-pyrimethamineSulphadoxine-pyrimethamineCYP2C8MedicinalLiquidSuspension1985TreatmentDosageDrugRecentProductsPlus amodiaquineArtesunate and amodiaquinePlasmodiumHydrochloride TabletsTabletsMefloquineChloroquine and amodiaquineLumefantrineArtemisinin-basedSulfadoxineProphylaxisAminoquinolinePotentDoseDrugsSubstratesDesethylamodiaquineAfricaWidely
Chloroquine9
- Editorial Note: Amodiaquine, a 4-aminoquinoline similar to chloroquine in structure and activity, has been used as both an antimalarial and an anti-inflammatory agent for more than 30 years. (cdc.gov)
- In April 1985, CDC revised its recommendations for preventing malaria in travelers, because of severe cutaneous reactions associated with the use of Fansidar, and recommended amodiaquine use for malaria prophylaxis could be considered as an alternative for longer-term travelers at risk of acquiring chloroquine-resistant Plasmodium falciparum (CRPF) (7). (cdc.gov)
- This recommendation was based on studies showing amodiaquine was somewhat more effective than chloroquine in treating CRPF infections (8) and, therefore, might provide more protection than chloroquine when used as weekly prophylaxis in areas where CRPF transmission occurs. (cdc.gov)
- Similarly, the World Health Organization recently suggested the use of amodiaquine as an alternative to chloroquine and recommended that it be used in combination with Paludrine or Maloprim (dapsone-pyrimethamine) for travel to certain areas (4). (cdc.gov)
- To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria. (biomedcentral.com)
- Day 28 adequate clinical and parasitological responses (ACPR) were 14.1%, 62.3% and 88.9% in 2002 and 18.2%, 60% and 85.2% in 2003 for chloroquine, amodiaquine and sulphadoxine-pyrimethamine, respectively. (biomedcentral.com)
- Amodiaquine therapy selected molecular markers for chloroquine resistance, while in the sulphadoxine-pyrimethamine arm the level of dhfr triple mutant and dhfr / dhps quadruple mutant increased from 31.5% and 3.8% in 2002 to 42.9% and 8.9% in 2003, respectively. (biomedcentral.com)
- A comparative study of amodiaquine and chloroquine in two test systems / by Peter Oyem Olise. (who.int)
- For many years, uncomplicated malaria was treated with chloroquine, amodiaquine, and a sulfadoxine-pyrimethamine combination. (bvsalud.org)
Malaria13
- Only rarely has amodiaquine been associated with agranulocytosis: of 13 reports published between 1955 and 1985, only three were associated with the use of amodiaquine at recommended dosages for malaria prophylaxis in the absence of the use of other drugs known to have similar toxicity (2,3). (cdc.gov)
- While previously used largely for treating malaria in endemic areas, amodiaquine has been increasingly recommended for chemoprophylaxis in nonimmune visitors to endemic areas (4,5). (cdc.gov)
- Alternatively, the recent increase in the number of agranulocytosis cases might be explained by an increase in the number of persons using amodiaquine for malaria prophylaxis. (cdc.gov)
- Although amodiaquine is not marketed in the United States, information provided by the manufacturer indicates that the number of Europeans using amodiaquine for malaria prophylaxis may have increased in 1985. (cdc.gov)
- Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. (cdc.gov)
- Locations of 14 study health centers, including 11 peripheral satellite health units and 3 referral health facilities for which increased sensitivity of Plasmodium falciparum to artesunate/amodiaquine despite 14 years as first-line malaria treatment was tested, Zanzibar. (cdc.gov)
- In this study, treatment with sulphadoxine-pyrimethamine emerged as the most efficacious on uncomplicated falciparum malaria followed by amodiaquine. (biomedcentral.com)
- Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial. (ox.ac.uk)
- ABSTRACT In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and with Plasmodium vivax malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days. (tropmedres.ac)
- Clinical tolerability of artesunate-amodiaquine versus comparator treatments for uncomplicated falciparum malaria: an individual-patient analysis of eight randomized controlled trials in sub-Saharan Africa. (ox.ac.uk)
- BackgroundThe widespread use of artesunate-amodiaquine (ASAQ) for treating uncomplicated malaria makes it important to gather and analyse information on its tolerability.MethodsAn individual-patient tolerability analysis was conducted using data from eight randomized controlled clinical trials conducted at 17 sites in nine sub-Saharan countries comparing ASAQ to other anti-malarial treatments. (ox.ac.uk)
- At 14 sentinel sites in six geographical areas of Nigeria, we evaluated treatment responses in 1341 children under 5 years and in additional 360 children under 16 years with uncomplicated malaria enrolled in randomized trials of artemether-lumefantrine versus artesunate-amodiaquine at 5-year interval in 2009-2010 and 2014-2015 and at 2-year interval in 2009-2010 and 2012-2015, respectively after deployment in 2005. (biomedcentral.com)
- Efficacy of artesunate-amodiaquine and artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria in Madagascar, 2018. (cdc.gov)
Artesunate9
- We assessed the safety, treatment efficacy, and effect on gametocyte carriage of adding artesunate to amodiaquine in three randomised trials in Kenya, Sénégal, and Gabon. (ox.ac.uk)
- Patients were randomly assigned amodiaquine (10 mg/kg per day for 3 days) plus artesunate (4 mg/kg per day for 3 days) or amodiaquine (as above) and placebo (for 3 days). (ox.ac.uk)
- Six patients in the amodiaquine-artesunate group and five in the amodiaquine group developed early, drug-induced vomiting, necessitating alternative treatment. (ox.ac.uk)
- INTERPRETATION:The combination of artesunate and amodiaquine improved treatment efficacy in Gabon and Kenya, and was equivalent in Sénégal. (ox.ac.uk)
- Amodiaquine-artesunate is a potential combination for use in Africa. (ox.ac.uk)
- Further investigations to assess the potential effect on the evolution of drug resistance, disease transmission, and safety of amodiaquine-artesunate are warranted. (ox.ac.uk)
- Effect of Artesunate-Amodiaquine on Mortality Related to Ebola Vir. (medbox.org)
- This makes it all too important to measure the dynamics of parasite clearance in African patients treated with ACT over time, to understand trends and detect changes early enough to intervene Individual patient data from 27 clinical trials of artesunate-amodiaquine (ASAQ) vs comparators conducted between 1999 and 2009 were analysed for parasite clearance on modified intent-to-treat (ITT) basis. (typeset.io)
- In parallel, Kaplan-Meier estimated risk of recurrent infections by day 28 rose from 8 to 14% ( P = 0.005) and from 9 to 15% ( P = 0.02) with artemether-lumefantrine and artesunate-amodiaquine, respectively. (biomedcentral.com)
Efficacy1
- Amodiaquine still retains efficacy against P falciparum in many African countries. (ox.ac.uk)
Sulfadoxine-pyrimethamine1
- of sulfadoxine-pyrimethamine and amodiaquine for three days. (who.int)
Sulphadoxine-pyrimethamine1
- The study demonstrated that sulphadoxine-pyrimethamine and amodiaquine were appropriate partner drugs that could be associated with artemisinin derivatives in an artemisinin-based combination therapy. (biomedcentral.com)
CYP2C81
- Amodiaquine was used as the substrate for CYP2C8, while midazolam was the CYP3A4 substrate. (helsinki.fi)
Medicinal1
- 30 August 2007 Amodiaquine Hydrochloride Tablets was included in the list of prequalified medicinal products. (who.int)
Liquid2
- Plasma was analyzed for amodiaquine and desethylamodiaquine by use of a liquid chromatography-tandem mass spectrometry method. (tropmedres.ac)
- High-performance liquid chromatographic analysis of amodiaquine in human plasma. (ox.ac.uk)
Suspension1
- The Amodiaquine Oral Suspension is an antimalarial medication used to treat acute malarial attacks characterized by symptoms such as chills, fever, and sweating. (apindexpharma.com)
19851
- in Switzerland, a threefold increase in amodiaquine sales was noted from 1984 to 1985. (cdc.gov)
Treatment1
- The results suggest that the current amodiaquine dosing regimen is adequate for the treatment of P. vivax infections during pregnancy. (tropmedres.ac)
Dosage1
- In all but four of the 25 cases, amodiaquine was used at the appropriate dosage (adults 400 mg base per week) for prophylaxis. (cdc.gov)
Drug2
- Sixteen additional cases of agranulocytosis from Western Europe associated with the use of amodiaquine have recently been reported to the drug manufacturer, and two U.S. cases have been reported to CDC. (cdc.gov)
- It is now apparent that any possible prophylactic advantage that amodiaquine may afford is not justified by the possible risk of agranulocytosis associated with the use of the drug. (cdc.gov)
Recent1
- The reason for the discrepancy between the previous and recent experiences with amodiaquine is not clear. (cdc.gov)
Products1
- Amodiaquine Hydrochloride Tablets were assessed according to the `Procedure for Assessing the Acceptability, in principle, of Pharmaceutical Products for purchase by United Nations Agencies' by the team of WHO assessors. (who.int)
Plus amodiaquine3
- Following WHO recommendations that prioritize the use of artemisinin-based combinations, artesunate plus amodiaquine could be a potential first-line treatment. (mediu.edu.my)
- A triple artemisinin-based combination therapy (TACT) of artemether-lumefantrine plus amodiaquine (AL+AQ) for uncomplicated falciparum malaria in areas with a high prevalence of artemisinin resistance is a well-tolerated, effective treatment for multidrug-resistant parasites, say a team of MORU-led researchers. (tropmedres.ac)
- The drugs (sulfadoxine-pyrimethamine plus amodiaquine, given to children once a month for a few months each year) don't give complete protection but the benefits are clearly visible, and the strategy has been welcomed by communities. (lshtm.ac.uk)
Artesunate and amodiaquine4
- Exporter of a wide range of products which include pyrimethamine and sulfadoxine tablets, artesunate and mefloquin tablets, amodiaquine hydrochloride tablets, artesunate and amodiaquine tablets, artemether and lumefantrine tablets and chloroquin phosphate tablets. (actizapharmacy.com)
- We are leading Exporter and Manufacturer supplier of Artesunate and Amodiaquine Tablets in India. (actizapharmacy.com)
- Artesunate and amodiaquine (AS+AQ) have been recommended by WHO as one of the preferred artemisinin combination treatments for malaria since the WHO treatment guidelines published in 2006. (essentialmeds.org)
- In Zanzibar, however, artesunate and amodiaquine are used. (volunteer-africa-blog.org)
Plasmodium8
- To compare amodiaquine with chloroquine or sulfadoxine-pyrimethamine for treating uncomplicated Plasmodium falciparum malaria. (neli.org.uk)
- Locations of 14 study health centers, including 11 peripheral satellite health units and 3 referral health facilities for which increased sensitivity of Plasmodium falciparum to artesunate/amodiaquine despite 14 years as first-line malaria treatment was tested, Zanzibar. (cdc.gov)
- To examine the kinetics of the disposition of Plasmodium falciparum during treatment with amodiaquine, a Mannich base derivative of chloroquine and chloroquine. (medscape.com)
- BACKGROUND: Artesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. (ox.ac.uk)
- Efficacy of chloroquine, sulfadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria among children under five in Bongor and Koumra, Chad. (mediu.edu.my)
- We assess chloroquine (CQ), sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) to treat Plasmodium falciparum uncomplicated malaria. (mediu.edu.my)
- Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis. (amedeo.com)
- Efficacy of artemether-lumefantrine, artesunate-amodiaquine, and dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015. (cdc.gov)
Hydrochloride Tablets4
- Amodiaquine Hydrochloride Tablets were assessed according to the `Procedure for Assessing the Acceptability, in principle, of Pharmaceutical Products for purchase by United Nations Agencies' by the team of WHO assessors. (who.int)
- The countries of origin of the assessors involved with Amodiaquine Hydrochloride Tablets were Czech Republic, Germany, Hungary, Netherlands, Spain, South Africa and Zimbabwe. (who.int)
- 30 August 2007 Amodiaquine Hydrochloride Tablets was included in the list of prequalified medicinal products. (who.int)
- We are leading Exporter and Manufacturer of Amodiaquine Hydrochloride Tablets. (actizapharmacy.com)
Tablets1
- Amodiaquine 76.5mg (as hydrochloride) + Sulfadoxine-Pyrimethamine 250 mg+ 12.5 mg dispersible tablets, Co-Blister of 3+1 tablets. (unicef.org)
Mefloquine1
- It is now obvious that the implementation and the global use of ACTs (Artemisinin Combined Therapies), combining a fast-acting artemisinin derivative (ART) and a slower-acting partner drug (i.e. amodiaquine, mefloquine, lumefantrine or piperaquine) has greatly contributed to the malaria endemicity decrease, especially in areas of low transmission such as Cambodia 1 . (pasteur.fr)
Chloroquine and amodiaquine2
- I was surprised to see he found many hits versus Ebola including the drugs chloroquine and amodiaquine. (collaborativedrug.com)
- Augmentation of gastric acid secretion by chloroquine and amodiaquine in the rat stomach 1ajeigbe k. (web.app)
Lumefantrine4
- Burkina Faso has recently changed its policy for the treatment of uncomplicated malaria, from Chloroquine to Artemether-Lumefantrine (AL) and Artesunate-Amodiaquine (AQ+AS). (clinicaltrials.gov)
- In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) was conducted in Mozambique, and the prevalence of polymorphisms in the pfk13, pfcrt, and pfmdr1 genes associated with drug resistance was investigated. (malariaworld.org)
- Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) as the first choice. (malariaworld.org)
- and resistance markers for Amodiaquine (AQ), Chloroquine (CQ), and Lumefantrine (LUM) found in P.falciparum pfmdr1 and pfcrt genes . (wwarn.org)
Artemisinin-based1
- The most commonly recommended combinations for Africa include non-artemisinin-based combinations, such as amodiaquine-sulphadoxine-pyrimethamine (AQ-SP), and artemisinin-based combinations, such as artesunate-amodiaquine (AS-AQ), artesunate-sulphadoxine-pyrimethamine (AS-SP), and artemether-lumefantrine (AM-LM). (biomedcentral.com)
Sulfadoxine5
- No significant difference for adverse events was observed between amodiaquine and chloroquine and sulfadoxine/pyrimethamine. (neli.org.uk)
- NEW YORK (Reuters Health) - A malaria study comparing monthly chemoprevention, vaccination, or both among children aged 5 months to 17 months has concluded that the combination works best, and that seasonal vaccination is not inferior to daily treatment with amodiaquine, sulfadoxine and pyrimethamine. (medscape.com)
- The sulfadoxine-pyrimethamine combination and amodiaquine were given as four treatments, one per month during each malaria season. (medscape.com)
- The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration of four monthly courses of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ), to children aged 3-59 months during rainy season. (malariaworld.org)
- Resistance of P. falciparum to antimalarials in Colombia is particularly concerning considering it was one of the first countries to report resistance to chloroquine in the 1960s, and today this resistance has expanded to include amodiaquine and sulfadoxine-pyrimethamine, thereby reducing available treatment options. (cideim.org.co)
Prophylaxis2
Aminoquinoline2
- Amodiaquine is an aminoquinoline used for the therapy of malaria. (nih.gov)
- Here we report for the first time that amodiaquine (AQ), a clinical 4-aminoquinoline antimalarial with unexplored cancer-directed chemotherapeutic potential, causes autophagic-lysosomal and proliferative blockade in melanoma cells that surpasses that of its parent compound chloroquine. (nih.gov)
Potent2
- The team chose the most potent, amodiaquine, for further testing. (nih.gov)
- A Wyss Institute-led collaboration spanning four research labs and hundreds of miles has used the institute's organ-on-a-chip (Organ Chip) technology to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes COVID-19. (harvard.edu)
Dose6
- CONCLUSIONS: There was substantial variation in the total dose of amodiaquine administered in different AS-AQ combination regimens. (ox.ac.uk)
- When administered in human Airway Chips under flow at a clinically relevant dose, one drug amodiaquine significantly inhibited infection by a pseudotyped SARS-CoV-2 virus. (mit.edu)
- The application was rejected because of uncertainty about the dose of amodiaquine in the FDC compared to the usually recommended dose, the relatively premature nature of the presentation of one of the key clinical trials and the uncertainty about the availability of a quality-assured product. (essentialmeds.org)
- Doubling the dose usually results in excess amodiaquine with the resultant risk of increased toxicity. (essentialmeds.org)
- within the management cluster (CT), one dose of amodiaquine (10 mg/kg) was administered orally to rats whereas within the co-administration cluster (CA), identical dose of AQ was given at the same time with MO. (digiwire.co.in)
- We need to have an alternative to Coartem which could be Artesunate-amodiaquine (AA) in a fixed dose combination (FDC), a cheaper altenative not yet evidenced to be effective and safe to our population. (org.bd)
Drugs2
- Pivoting their efforts to COVID-19, the researchers then used the chips to identify three approved drugs-amodiaquine, toremifene, and clomiphene-that could reduce SARS-CoV-2 entry into human lung cells. (nih.gov)
- Based in part on these results, amodiaquine has been incorporated into the ongoing ANTICOV clinical trial, which is testing drugs to treat COVID-19 in 13 African countries. (nih.gov)
Substrates1
- In this paper, we show that this mutant, but not wild-type BM3, is able to metabolise testosterone and several drug-like molecules such as amodiaquine, dextromethorphan, acetaminophen, and 3,4-methylenedioxymethylamphetamine that are known substrates of human P450s. (vu.nl)
Desethylamodiaquine1
- Proof of concept was provided by showing that amodiaquine and its active metabolite (desethylamodiaquine) also significantly reduce viral load in both direct infection and animal-to-animal transmission models of native SARS-CoV-2 infection in hamsters. (mit.edu)
Africa2
- In many parts of Africa, one of the effective alternatives to chloroquine is amodiaquine, a Mannich base derivative of chloroquine. (medscape.com)
- Amodiaquine is now in clinical trials for COVID-19 at multiple sites in Africa, where this drug is inexpensive and widely available. (harvard.edu)
Widely1
- Amodiaquine has been widely used to treat malaria. (neli.org.uk)