A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
A proline analog that acts as a stoichiometric replacement of proline. It causes the production of abnormal proteins with impaired biological activity.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.
Therapy with two or more separate preparations given for a combined effect.
Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.
A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
Compounds with a BENZENE fused to IMIDAZOLES.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

Effects of amlodipine on sympathetic nerve traffic and baroreflex control of circulation in heart failure. (1/462)

Short-acting calcium antagonists exert a sympathoexcitation that in heart failure further enhances an already elevated sympathetic activity. Whether this is also the case for long-acting formulations is not yet established, despite the prognostic importance of sympathetic activation in heart failure. It is also undetermined whether in this condition long-acting calcium antagonists favorably affect a mechanism potentially responsible for the sympathetic activation, ie, the baroreflex impairment. In 28 heart failure patients (NYHA functional class II) under conventional treatment we measured plasma norepinephrine and efferent postganglionic muscle sympathetic nerve activity (microneurography) at rest and during arterial baroreceptor stimulation and deactivation induced by stepwise intravenous infusions of phenylephrine and nitroprusside, respectively. Measurements were performed at baseline and after 8 weeks of daily oral amlodipine administration (10 mg/d, 14 patients) or before and after an 8-week period without calcium antagonist administration (14 patients). Amlodipine caused a small and insignificant blood pressure reduction. Heart rate, left ventricular ejection fraction, and plasma renin and aldosterone concentrations were not affected. This was the case also for plasma norepinephrine (from 2.43+/-0.41 to 2.50+/-0.34 nmol/L, mean+/-SEM), muscle sympathetic nerve activity (from 54.4+/-5.9 to 51.0+/-4.3 bursts/min), and arterial baroreflex responses. No change in the above-mentioned variables was seen in the control group. Thus, in mild heart failure amlodipine treatment does not adversely affect sympathetic activity and baroreflex control of the heart and sympathetic tone. This implies that in this condition long-acting calcium antagonists can be administered without untoward neurohumoral effects anytime conventional treatment needs to be complemented by drugs causing additional vasodilatation.  (+info)

Irbesartan reduces QT dispersion in hypertensive individuals. (2/462)

Angiotensin type 1 receptor antagonists have direct effects on the autonomic nervous system and myocardium. Because of this, we hypothesized that irbesartan would reduce QT dispersion to a greater degree than amlodipine, a highly selective vasodilator. To test this, we gathered electrocardiographic (ECG) data from a multinational, multicenter, randomized, double-blind parallel group study that compared the antihypertensive efficacy of irbesartan and amlodipine in elderly subjects with mild to moderate hypertension. Subjects were treated for 6 months with either drug. Hydrochlorothiazide and atenolol were added after 12 weeks if blood pressure (BP) remained uncontrolled. ECGs were obtained before randomization and at 6 months. A total of 188 subjects (118 with baseline ECGs) were randomized. We analyzed 104 subjects who had complete ECGs at baseline and after 6 months of treatment. Baseline characteristics between treatments were similar, apart from a slight imbalance in diastolic BP (irbesartan [n=53] versus amlodipine [n=51], 99.2 [SD 3. 6] versus 100.8 [3.8] mm Hg; P=0.03). There were no significant differences in BP normalization (diastolic BP <90 mm Hg) between treatments at 6 months (irbesartan versus amlodipine, 80% versus 88%; P=0.378). We found a significant reduction in QT indexes in the irbesartan group (QTc dispersion mean, -11.4 [34.5] milliseconds, P=0.02; QTc max, -12.8 [35.5] milliseconds, P=0.01), and QTc dispersion did not correlate with the change in BP. The reduction in QT indexes with amlodipine (QTc dispersion, -9.7 [35.4] milliseconds, P=0.06; QTc max, -8.6 [33.2] milliseconds, P=0.07) did not quite reach statistical significance, but there was a correlation between the change in QT indexes and changes in systolic BP. In conclusion, irbesartan improved QT dispersion, and this effect may be important in preventing sudden cardiac death in at-risk hypertensive subjects.  (+info)

Low-dose combination therapy as first-line hypertension treatment for blacks and nonblacks. (3/462)

To assess the efficacy and safety of bisoprolol/6.25-mg hydrochlorothiazide (HCTZ), amlodipine, and enalapril in black and nonblack patients, data from two comparative studies were pooled and subgroup analyses performed. Both studies had similar designs and included all three active treatments. The second study also included a placebo group. Subjects (n = 541) with a sitting diastolic blood pressure of 95-114 mmHg were titrated to achieve a diastolic blood pressure < or = 90 mmHg. The studies included 114 blacks and 427 nonblacks. Results of an intention-to-treat analysis of mean change from baseline after 12 weeks of treatment showed the following: 1) blood pressure was significantly lowered by all three active drugs compared with baseline or placebo; 2) in blacks, bisoprolol/6.25-mg HCTZ resulted in significantly greater reductions of systolic and diastolic blood pressure than enalapril or placebo, but was not significantly different from amlodipine; 3) in nonblacks, bisoprolol/6.25-mg HCTZ resulted in significantly greater reduction of diastolic blood pressure than amlodipine, enalapril, or placebo. The placebo-corrected change in blood pressure was greater for blacks than whites on the bisoprolol/6.25-mg HCTZ combination, but this was not statistically significant. Bisoprolol/6.25-mg HCTZ controlled diastolic blood pressure to < or = 90 mmHg in significantly more patients than enalapril or placebo in blacks and nonblacks. The difference in control rates was not significant versus amlodipine. The incidence of drug-related adverse events was similar between treatments; however, bisoprolol/6.25-mg HCTZ had a lower discontinuation rate due to lack of blood pressure control or adverse experiences in both blacks and nonblacks.  (+info)

Renal effects of amlodipine in normotensive renal transplant recipients. (4/462)

Renal effects of amlodipine in normotensive renal transplant recipients. The use of cyclosporin A (CsA) has improved the success of renal transplantation, but is associated with hypertension and significant renal toxicity. Previous reports suggest that calcium channel blockers may be useful in opposing the adverse effects of CsA. We have evaluated the effects of amlodipine (5 mg, once daily for 8 weeks) on renal function in 27 normotensive renal transplant recipients with stable renal function, in a double-blind, placebo-controlled, multicentre, cross over study. Amlodipine significantly reduced serum creatinine concentration relative to placebo (mean+/-SD: 168+/-65 vs 177+/-66 micromol/l; P=0.002) and there was a strong trend towards an increase in effective renal plasma flow on amlodipine relative to placebo (238+/-92 vs 217+/-87 ml/min; P=0.055). Glomerular filtration rate and lithium clearance were unaffected. Trough CsA blood concentration was unaffected. Amlodipine was well tolerated, with a low incidence of adverse events, and did not affect blood pressure or heart rate. In conclusion, amlodipine reduced serum creatinine in normotensive renal transplant recipients after only 8 weeks treatment, and was well tolerated in concomitant administration with CsA.  (+info)

Beneficial effect of myocardial angiogenesis on cardiac remodeling process by amlodipine and MCI-154. (5/462)

The present study examined the effect of long-term treatment with amlodipine and MCI-154 (a Ca2+ sensitizer) on progressive cardiac dysfunction and microvasculature in the dilated cardiomyopathic (DCM) hamster heart. After treatment of DCM hamsters (Bio 53.58) with amlodipine or MCI-154 for 15 wk from the age of 5 wk, amlodipine and MCI-154 were found to cause an increase in left ventricular percent fractional shortening and decreases in left ventricular diastolic dimension and isovolumic relaxation time in echocardiograms (P < 0.01). A hemodynamic study showed that the diastolic time constant decreased in the amlodipine-treatment group (P < 0.05). In a morphometric study employing a double-staining method that discriminated arteriolar and venular capillaries, amlodipine and MCI-154 caused increases in total capillary density (P < 0.05) and the proportion of venular capillaries (P < 0.05). Moreover, Northern blot analysis showed that the expression of mRNA for vascular endothelial growth factor was significantly increased by amlodipine and MCI-154. They preserve coronary microvasculature in the DCM hamster and might induce angiogenesis of small vessels, thereby contributing to preservation of cardiac systolic and diastolic function.  (+info)

Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. (6/462)

BACKGROUND: Angiotensin II activates NAD(P)H-dependent oxidases via AT1-receptor stimulation, the most important vascular source of superoxide (O2*-). The AT1 receptor is upregulated in vitro by low-density lipoprotein. The present study was designed to test whether hypercholesterolemia is associated with increased NAD(P)H-dependent vascular O2*- production and whether AT1-receptor blockade may inhibit this oxidase and in parallel improve endothelial dysfunction. METHODS AND RESULTS: Vascular responses were determined by isometric tension studies, and relative rates of vascular O2*- production were determined by use of chemiluminescence with lucigenin, a cypridina luciferin analogue, and electron spin resonance studies. AT1-receptor mRNA was quantified by Northern analysis, and AT1-receptor density was measured by radioligand binding assays. Hypercholesterolemia was associated with impaired endothelium-dependent vasodilation and increased O2*- production in intact vessels. In vessel homogenates, we found a significant activation of NADH-driven O2*- production in both models of hyperlipidemia. Treatment of cholesterol-fed animals with the AT1-receptor antagonist Bay 10-6734 improved endothelial dysfunction, normalized vascular O2*- and NADH-oxidase activity, decreased macrophage infiltration, and reduced early plaque formation. In the setting of hypercholesterolemia, the aortic AT1 receptor mRNA was upregulated to 166+/-11%, accompanied by a comparable increase in AT1-receptor density. CONCLUSIONS: Hypercholesterolemia is associated with AT1-receptor upregulation, endothelial dysfunction, and increased NADH-dependent vascular O2*- production. The improvement of endothelial dysfunction, inhibition of the oxidase, and reduction of early plaque formation by an AT1-receptor antagonist suggests a crucial role of angiotensin II-mediated O2*- production in the early stage of atherosclerosis.  (+info)

Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure. (7/462)

BACKGROUND: Inhibition of angiotensin-converting enzyme (ACE) reduces the risk of cardiovascular problems in patients with chronic renal failure. This effect may be due in part to a decrease in sympathetic nervous activity, but no direct evidence of such an action is available. METHODS: We studied muscle sympathetic-nerve activity in 14 patients with hypertension, chronic renal failure, and increased plasma renin activity before, during, and after administration of the ACE inhibitor enalapril. Ten other patients with similar clinical characteristics were studied before and during treatment with the calcium-channel blocker amlodipine. Normal subjects matched for age and weight were included in both studies. RESULTS: At base line, mean (+/-SD) muscle sympathetic-nerve activity was higher in the group of patients who received enalapril than in the control subjects (35+/-17 vs. 19+/-9 bursts per minute, P=0.004). The baroreflex curve, which reflects changes in muscle sympathetic-nerve activity caused by manipulations of blood pressure with sodium nitroprusside and phenylephrine, was shifted to the right in the patients, but baroreflex sensitivity was similar to that in the control subjects (-2.1+/-1.9 and -2.7+/-1.3 bursts per minute per mm Hg, respectively; P=0.36). A single dose of the sympatholytic drug clonidine caused a greater fall in blood pressure in the patients than in the control subjects. Treatment with enalapril normalized blood pressure and muscle sympathetic-nerve activity (at 23+/-10 bursts per minute) in the patients and shifted the baroreflex curve to the left, reflecting normal blood-pressure levels, without significantly changing sensitivity (-2.3+/-1.8 bursts per minute per mm Hg, P=0.96). In the patients who received amlodipine, treatment also lowered blood pressure but increased muscle sympathetic-nerve activity, from 41+/-19 to 56+/-14 bursts per minute (P=0.02). CONCLUSIONS: Increased sympathetic activity contributes to hypertension in patients with chronic renal disease. ACE inhibition controls hypertension and decreases sympathetic hyperactivity.  (+info)

Combination of calcium channel blockers and beta-adrenoceptor blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers. Netherlands Working Group on Cardiovascular Research (WCN). (8/462)

AIMS: The combination of calcium channel blockers and beta-adrenoceptor blockers is more effective for the treatment of exercise-induced angina pectoris than beta-adrenoceptor blocker monotherapy. As ischaemia in exercise-induced angina is preceded by increase in heart rate, calcium channel blockers with negative chronotropic properties may perform better for this purpose than nonchronotropic compounds. METHODS: A 335 patient double-blind parallel-group study comparing 14 day treatment with amlodipine 5 and 10 mg, with diltiazem 200 and 300 mg, and mibefradil 50 and 100 mg added to baseline beta-adrenoceptor blocker treatment was performed. Exercise testing (ETT) was performed by bicycle ergometry. RESULTS: Although none of the calcium channel blockers improved duration of exercise or amount of workload, all significantly delayed onset of 1 mm ST-segment depression on ETT (P<0.001 for any treatment vs baseline). In addition, mibefradil, both low and high dose treatment, produced the longest delays (low dose: different from diltiazem and amlodipine by 24.1 and 29.8 s, respectively, P<0. 003 and <0.001; high dose: different from diltiazem and amlodipine by 33.7 and 37.0 s, respectively, P<0.001 and <0.001). These effects were linearly correlated with the reduction in rate pressure product (RPP). Serious symptoms of dizziness occurred significantly more frequently on mibefradil (P<0.05), and 19 patients on mibefradil withdrew from trial. CONCLUSIONS: Calcium channel blockers with negative chronotropic properties provide greater delay of ischaemia in patients with exercise-induced angina, but the concomitant risk of intolerable dizziness attenuates this benefit.  (+info)

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Cadila Pharmaceuticals is a one of the foremost pharma companies in synthesizing APIs. We are bulk drug manufacturer of Amlodipine Besylate. The CAS number of Amlodipine Besylate is 88150-42-9.. Amlodipine is used to treat high blood pressure. Lowering high blood pressure helps to prevent heart attack, strokes and kidney problems. Amlodipine Besylate is a calcium channel blocker drug. It relaxes blood vessels so blood can flow easily. It is also used to prevent certain types of chest pain.. Cadila Pharmaceuticals Limited is one of the top USFDA approved pharmaceutical companies based in India. It is respected as a best Active Pharmaceutical Ingredients (APIs) manufacturing company in India. One of our core expertises is to synthesize APIs of the highest quality at inexpensive price.. We are major Amlodipine Besylate manufacturer and supplier. We export Amlodipine Besylate to Asian countries like; Japan, China, Georgia, Singapore, Malaysia, Vietnam, South Korea etc., and Middle East countries ...
If you become pregnant while taking Amlodipine Besylate, tell your doctor immediately.. You should not take this medicine while you are pregnant.. Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed.. Otherwise your doctor may think that it was not effective and change your treatment unnecessarily.. Be sure to keep all of your doctors appointments so that your progress can be checked. Do this even if you feel well.. People with high blood pressure often do not notice any signs of this problem. But it is important to keep track of your progress. Your doctor will want to check your blood pressure and your kidney and liver function from time to time.. If you are going to have surgery, tell your doctor and anaesthetist that you are taking Amlodipine Besylate.. Amlodipine Besylate may affect some medicines you receive during surgery.. If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking Amlodipine ...
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1. Study name: Intensive management of blood pressure and cholesterol in elderly Chinese with hypertension and atrial fibrillation (IMPRESSION) 2. Medicine: amlodipine/atorvastatin (5/10mg tablet); amlodipine/atorvastatin (5/20mg tablet); allisartan (240mg/tablet). 3. Rationale: controlling blood pressure and cholesterol are both effective means to reduce cardiovascular risks, however, it is still unknown whether high cardiovascular risk patients with atrial fibrillation would benefit from intensive management of blood pressure and cholesterol. 4. Objective: To evaluate the efficacy and safety of intensive management of blood pressure and cholesterol. 5. Study design: This study is a multi-center, randomized and controlled clinical trial with four equally sized treatment groups: amlodipine/atorvastatin (5/10mg tablet); amlodipine/atorvastatin (5/20mg tablet); amlodipine
Présentations du médicament AMLODIPINE ALMUS. AMLODIPINE ALMUS 5 mg: gélule ; boîte de Sur ordonnance (Liste I) - Remboursable à 65 % - Prix: 4,82 €. AMLODIPINE ALMUS 5 mg: gélule ; boîte de Sur ordonnance (Liste I) - Remboursable à 65 % - Prix: 13,45 €. AMLODIPINE ALMUS AMLODIPINE MYLAN (Inhibiteur calcique): fiche médicament du Vidal de la famille précisant la composition, la posologie, les interactions possibles, les effets indésirables éventuels.. Am or pm suspensie amlodipine lijek besy 5mg a ace hemmer. Besylate kidneys side effects exists side effects of coming off norvasc treatment cancer dosage for dogs. Besylate hypothyroid positive effects amlodipine amlodipine 5 mg eureka mg ingredients 10 mg eureka besylate off label use. Besylate uneconomical buy without prescription using. Amlodipine Cor Vidal. Amlodipine is needed to treat hypertension (high blood pressure) and to work angina (chest cane). Amlodipine may also be used for amlodipine 5 mg eureka other ...
AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE - amlodipine besylate and benazepril hydrochloride capsule - Prescription (RX) Marketed Drugs Encyclopedia
AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE - amlodipine besylate and benazepril hydrochloride capsule - Prescription (RX) Marketed Drugs Encyclopedia
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The combination of benazepril plus amlodipine was shown to be more effective than benazepril plus hydrochlorothiazide in reducing cardiovascular events in the Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial. There was a small difference in clinic systolic blood pressure between the treatment arms favoring benazepril plus amlodipine. Ambulatory blood pressure monitoring provides a more rigorous estimate of blood pressure effects. A subset of 573 subjects underwent ambulatory blood pressure monitoring during year 2. Readings were obtained every 20 minutes during a 24-hour period. Between-treatment differences (benazepril plus amlodipine versus benazepril plus hydrochlorothiazide) in mean values were analyzed using ANOVA. Treatment comparisons with respect to categorical variables were made using Pearsons χ2. At year 2, the treatment groups did not differ significantly in 24-hour mean daytime or nighttime blood pressures ...
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Patient Information Amlodipine Besylate and Benazepril Hydrochloride Capsules, 2.5 mg/10 mg, 5 mg/10 mg, 5 mg/20 mg, 10 mg/20 mg Read this Patient Information leaflet before you start taking amlodipine besylate and benazepril hydrochloride capsules and each time you get a refill. There may be new information. This leaflet does not replace talking with your doctor. If you have any questions, ask your doctor or pharmacist.. What is the most important information I should know about amlodipine besylate and benazepril hydrochloride capsules? Amlodipine besylate and benazepril hydrochloride capsules can harm an unborn baby and even cause death. If you get pregnant, stop taking amlodipine besylate and benazepril hydrochloride capsules. Call your doctor right away. Talk to your doctor about other ways to lower your blood pressure if you plan to become pregnant.. What is amlodipine besylate and benazepril hydrochloride capsules? Amlodipine besylate and benazepril hydrochloride capsules contains two ...
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BACKGROUND: Single-pill amlodipine/atorvastatin targets the two most common modifiable cardiovascular risk factors, hypertension and dyslipidaemia. We evaluated the clinical utility of this single pill to help patients across Europe and Canada achieve country-specific targets for blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C). DESIGN: Two 16-week, open-label studies conducted in 122 study centres across the United Kingdom and Canada (JEWEL 1) and 113 centres across 11 European countries (JEWEL 2). METHODS: Patients with uncontrolled BP and controlled/uncontrolled LDL-C qualifying for treatment according to local governing guidelines were administered single-pill amlodipine/atorvastatin with appropriate lifestyle modification. Eight dosages of amlodipine/atorvastatin (5/10-10/80-mg) were titrated to achieve country-specific BP and LDL-C targets. The primary outcome was the percentage of patients reaching country-specific BP and LDL-C targets in 16 weeks. RESULTS: Among 2245 patients
Amlodipine is used in the treatment of hypertension and myocardial ischemia caused by angina. It is marketed in the form of a compound with various salts such as amlodipine besylate, amlodipine maleate, amlodipine camsylate, and amlodipine orotate. There is also a form of the enantiomeric S-isomer of amlodipine called S-amlodipine. Among these, amlodipine besylate can be used for the prevention of angina pectoris or coronary revascularization in patients with no heart failure or less than 40% cardiac output among patients whose cardiovascular disease was confirmed by angiography. In addition, amlodipine is used not only as a single drug, but also as a combination drug with other blood pressure drugs to effectively control blood pressure while minimizing side effects, and it is also used with hyperlipidemia treatments to treat hyperlipidemia, which is likely to occur in patients with heart disease.. ...
There are several generics of Amlodipine besylate tablets locally manufactured by some Syrian pharmaceutical companies. this study tries to evaluate the pharmaceutical and chemical equivalence of amlodipine besylate tablets from 5 Syrian pharmaceuticals and comparison the results with an innovator (Norvasc®). The pharmaceutical equivalence and the quality for each generic were assessed through the evaluation of standard tests such as uniformity of weight, friability, hardness, disintegration, content uniformity, uniformity of dosage units and dissolution rate. The assay was conducted by using HPLC (the analytical column was C 18, 150 x 4.6 mm I.D, 4µm particle size, the mobile phase was a mixture of 30% acetonitrile and 70% 100 mM ammonium acetate pH 5 with flow rate of 1ml/min and UV detection at 237 nm for amlodipine). All the generics complied with the standard specifications for uniformity of weight (|±7.5%), friability (|1%), content uniformity (85-115%), uniformity of dosage units (|15),
Amlodipine is a calcium Amlodipine shop Online blocker, which works by blocking the transport of calcium into the smooth muscle cells www.daime.com.hk dont experience symptoms when suffering from high blood pressure. What dosages are available for Amlodipine? You can buy Amlodipine besylate in two different Amlodipine shops Online from HealthExpress: The dosage prescribed depends on your medical condition and your response to the Amlodipine shop Online. Its likely that youll Amlodipine shop Online on a lower dosage, which will increase depending on its effectiveness as well as any possible side effects you experience.. The maximum dosage of Amlodipine which you can take each day is 10mg. What happens if I miss a dose? If you miss a dose, it isnt a disaster, so simply take the missed dose as soon as you remember and skip the missed dose if it is almost time for your next scheduled dose. It is advised not to take an extra Amlodipine tablet to make up for the missed dose. Are there any ...
Amlodipine. No evidence of teratogenicity or other embryo/fetal toxicity was found when pregnant rats and rabbits were treated orally with amlodipine maleate at doses of up to 10 mg amlodipine/kg/day (respectively about 10 and 20 times the maximum recommended human dose of 10 mg amlodipine on a mg/m2 basis) during their respective periods of major organogenesis. (Calculations based on a patient weight of 60 kg). However, litter size was significantly decreased (by about 50%) and the number of intrauterine deaths was significantly increased (about 5-fold) in rats receiving amlodipine maleate at a dose equivalent to 10 mg amlodipine/kg/day for 14 days before mating and throughout mating and gestation. Amlodipine maleate has been shown to prolong both the gestational period and the duration of labor in rats at this dose. There are no adequate and well-controlled studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the ...
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TY - JOUR. T1 - Benazepril combined with either amlodipine or hydrochlorothiazide is more effective than monotherapy for blood pressure control and prevention of end-organ injury in hypertensive Dahl rats. AU - Zhou, Ming Sheng. AU - Jaimes, Edgar A.. AU - Raij, Leopoldo. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2006/7. Y1 - 2006/7. N2 - We studied the effect of hydrochlorothiazide (HCTZ), the angiotensin-converting enzyme inhibitor benazepril, the calcium channel blocker amlodipine, or a combination of benazepril/amlodipine or benazepril/HCTZ on systolic blood pressure (BP) and end-organ injury (left ventricular hypertrophy, proteinuria, and endothelium-dependent relaxation to acetylcholine) in hypertensive Dahl salt-sensitive rats fed either a normal-salt (0.5% NaCl) or high-salt (4% NaCl) diet for 6 weeks. Rats fed a high-salt diet developed hypertension and significant end-organ injury. Monotherapy with HCTZ (75 mg/L in drinking water) or amlodipine (10 ...
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Dive into the research topics of Efficacy and safety profiles of a new S(-)-amlodipine nicotinate formulation versus racemic amlodipine besylate in adult Korean patients with mild to moderate hypertension: An 8-week, multicenter, randomized, double-blind, double-dummy, parallel-group, phase III, noninferiority clinical trial. Together they form a unique fingerprint. ...
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Background: Endothelial cell (EC) dysfunction is causally related to atherosclerosis and hypertension. Aliskiren, a direct renin inhibitor, and amlodipine, a calcium channel blocker, have each been shown to improve vascular function; however, their combined effects are not understood. In this study, we tested the separate versus combined effects of aliskiren and amlodipine on aortic and glomerular EC function.. Methods: Spontaneously hypertensive (SH) rats were assigned to four treatment groups: (1) vehicle; (2) 40 mg/kg/day aliskiren; (3) 5 mg/kg/day amlodipine; and (4) combined aliskiren and amlodipine treatment (at 40 and 5 mg/kg/day, respectively). Each group contained 8 animals and treatments were administered for 8 weeks. Endothelial nitric oxide (NO) and peroxynitrite (ONOO-) release from aortic and glomerular ECs were measured ex vivo using amperometric nanosensors and correlated with systemic blood pressure (BP) measurements.. Results: Aliskiren and amlodipine improved NO release in a ...
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METHODS: Twelve mild-to-moderate essential hypertensives were investigated in this open, randomized cross-over study. Blood pressure and heart rate were measured by use of ambulatory blood pressure monitoring after a wash-out period of 1 week and after treatment schedules with 5 mg amlodipine once a day either. Amlodipine is a calcium channel blocker that dilates blood vessels and improves blood flow. Amlodipine is used to treat chest pain (angina) and other conditions caused by coronary artery disease. Amlodipine is also used to treat high blood pressure. It does not matter what time of day you take amlodipine.. You may have to take what time of day should i take amlodipine blood pressure medicine for the breakdown of your life. If estoque blood pressure is not treated, it can cure serious problems such as other failure, blood pressure disease, stroke, or kidney disease. You may take this morning with or without food. Take this medicine at the same situation each day. Their doctor will discuss ...
Patients with end-stage renal failure have a markedly higher mortality because of cardiovascular events in comparison with the normal population. Disorders in the calcium metabolism, such as calcification of the vessel walls, occur very frequently. There are indications that calcium channel blockers are capable of lowering the cardiovascular mortality in patients with end-stage renal failure.. It is intended to carry out a prospective, randomized, double-blind, placebo-controlled, multicenter study in order to find out if the calcium channel blocker amlodipine is able to reduce the mortality of patients with end-stage renal failure.. The investigation will be carried out after suitable explanation and written informed consent in 356 patients aged between 18 and 90 years with end-stage renal failure and chronic haemodialysis treatment. The patients will be randomized to either treatment with amlodipine 10 mg/day or placebo. The occurrence of events will be documented and evaluated prospectively ...
In male Wistar rats [light(L): 07:00-19:00 h, dark(D): 19:00-07:00 h], the effects of the calcium channel blocker amlodipine (1, 3, 10 mg/kg i.p.) on blood pressure, heart rate, and motor activity were studied by telemetric monitoring. Amlodipine was
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Azelnidipine plus olmesartan versus amlodipine plus olmesartan on arterial stiffness and cardiac function in hypertensive patients: a randomized trial Takeshi Takami,1 Yoshihiko Saito21Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan; 2First Department of Internal Medicine, Nara Medical University, Kashihara, JapanPurpose: To compare the long-term effects of olmesartan combined with either azelnidipine or amlodipine on central blood pressure (CBP), left ventricular (LV) mass index (LVMI), LV diastolic function (e´ velocity, E/e´ ratio, E/A ratio) and arterial stiffness (brachial-ankle pulse wave velocity [baPWV] and augmentation index normalized for a heart rate of 75 bpm [AIx]).Patients and methods: Patients with systolic BP ≥140 mmHg and/or diastolic BP ≥ 90 mmHg received olmesartan monotherapy (20 mg/day) for 12 weeks. They were then randomly assigned to fixed-dose add-on therapy with azelnidipine (16 mg/day; n = 26) or amlodipine (5 mg/day; n = 26) for a further 2 years. CBP,
The increased viscosity of blood of hypertensive patients can be assumed to be a risk factor for the development of cardiovascular diseases. The aim of the present study was to elucidate whether anti-hypertensive treatment has any impact on blood theology.. Twenty patients with previously untreated hypertension who consecutively attended our outpatient hypertension clinic were included in this prospective, open, cross-over study. The patients were randomly selected to treatment with amlodipine or metoprolol. The antihypertensive therapy was switched after 4 months. Haemorheological and haemodynamic variables were measured with rotational viscometry and impedance cardiography, respectively.. Fifteen and 16 patients could be evaluated after amlodipine or metoprolol treatment respectively. The mean blood pressure (BP) decreased from 159 +/- 22/105 +/- 7 to 139 +/- 21/91 +/- 6 mm Hg on amlodipine and from 162 +/- 22/104 +/- 5 to 145 +/- 24/90 +/- 8 mm Hg on metoprolol therapy. After amlodipine ...
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Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow. Perindopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Perindopril also widens blood vessels and also prevents the body from retaining water. Amlodipine and perindopril is a combination...
Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow. Perindopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Perindopril also widens blood vessels and also prevents the body from retaining water. Amlodipine and perindopril is a combination...
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In the investigation of Pumpkin seed oil and it effects on cardiovascular diseases indicated that after Pumpkin seed oil (40 or 100?mg/kg), amlodipine (0.9?mg/kg), or vehicle (control) was given once daily orally for 6 weeks, l-NAME administration resulted in a significant increase in BP starting from the second week. Pumpkin seed oil or amlodipine treatment significantly reduced the elevation in BP by l-NAME(nitro-l-arginine methyl ester hydrochloride) and normalized the l-NAME-induced ECG(electrocardiogram ) changes?namely, prolongation of the RR interval, increased P wave duration, and ST elevation. Both treatments significantly decreased the elevated levels of MDA(plasma malondialdehyde) and reversed the decreased levels of NO(serum nitric oxide) metabolites to near normal values compared with the l-NAME-treated group according to the study of Antihypertensive and Cardioprotective Effects of Pumpkin Seed Oil by El-Mosallamy AE, Sleem AA, Abdel-Salam OM, Shaffie N, Kenawy SA.(a ...
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OBJECTIVE: This study aims to establish the benefits of lowering cholesterol in diabetic patients with well-controlled hypertension and average/below-average cholesterol concentrations, but without established coronary disease. RESEARCH DESIGN AND METHODS: In the lipid-lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-LLA), 10,305 hypertensive patients with no history of coronary heart disease (CHD) but at least three cardiovascular risk factors were randomly assigned to receive 10 mg atorvastatin or placebo. Effects on total cardiovascular outcomes in 2,532 patients who had type 2 diabetes at randomization were compared. RESULTS: During a median follow-up of 3.3 years, concentrations of total and LDL cholesterol among diabetic participants included in ASCOT-LLA were approximately 1 mmol/l lower in those allocated atorvastatin compared with placebo. There were 116 (9.2%) major cardiovascular events or procedures in the atorvastatin group and 151 (11.9%) events in the placebo group
The effect of long−term treatment with dihydropyridine calcium antagonists(amlodipine, pranidipine, nicardipine)on the periarterial nerve function was investigated in the perfused mesenteric vascular bed isolated from spontaneously hypertensive rat(SHR).Male 8−week−old SHR received amlodipine(0.01% and 0.02%)and nicardipine(0.1%)in drinking water and pranidipine(0.0035% and 0.035%)in rat chow for 7 weeks.Mean blood pressure in SHR was significantly lowered by long−term treatment with each calcium antagonist.In mesenteric vascular preparations treated with each calcium antagonist, vasoconstriction induced by periarterial nerve stimulation(PNS;4, 8 and 12 Hz)was significantly smaller than that in non−treated SHR.The PNS(8 Hz)−evoked norepinephrine(NE)overflow in the perfusate was significantly decreased by amlodipine and pranidipine treatment, whereas nicardipine−treatment significantly enhanced the overflow of NE.In preparations with active tone produced by methoxamine and ...
Tribenzor contiene una combinación de amlodipina, hydrochlorothiazide y olmesartán. Amlodipino es un bloqueador de canales de calcio que se relaja (ensancha) los vasos de la sangre y mejora el flujo sanguíneo. hidroclorotiazida es un diurético tiazida (pastilla) que ayuda a evitar que su cuerpo absorba demasiada sal, que puede causar retención de líquidos. El olmesartán es un receptor antagonista de angiotensina II que mantiene los vasos sanguíneos de estrechamiento, que baja la presión arterial y mejora el flujo sanguíneo. Tribenzor se utiliza para tratar la presión arterial alta (hipertensión). . Genérico Tribenzor (Olmesartan, Amlodipine And Hydrochlorothiazide 20mg + 5mg + 12.5/40mg + 5mg + 12.5mg) € 1.65 comprimido -Enfermedades Cardiovasculares, Presión Arterial, Enfermedades Genitourinarias @ All America Trusts | AllAmericaTrusts.com. All America Trusts - AllAmericaTrusts.com
Tribenzor contém uma combinação de anlodipina, hidroclorotiazida e olmesartana. Anlodipina é um bloqueador dos canais de cálcio que relaxa (amplia) os vasos sanguíneos e melhora o fluxo sanguíneo. Hidroclorotiazida é um diurético tiazídico (pílula de água) que ajuda a evitar a absorção excessiva de sal pelo organismo, o que pode causar retenção de líquidos. Olmesartana é um bloqueador do receptor da angiotensina II que previne o estreitamento dos vasos sanguíneos, reduzindo assim a pressão arterial e melhorando o fluxo sanguíneo. Tribenzor é utilizado no tratamento da pressão arterial elevada (hipertensão). . Genéricos Tribenzor (Olmesartan, Amlodipine And Hydrochlorothiazide 20mg + 5mg + 12.5/40mg + 5mg + 12.5mg) € 1.93 comprimido - Doenças Cardiovasculares, Hipertensão Arterial, Trato Urinário @ Canadian online pharmacy. Cheap Canadian online pharmacy
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Julius S, Kjeldsen SE, Weber M, Brunner HR, Ekman S, Hansson L, Hua T, Laragh J, McInnes GT, Mitchell L, Plat F, Schork A, Smith B, Zanchetti A, VALUE trial group. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet. 2004; 363(9426): 2022-31 ...
Study to evaluate real-world safety, effectiveness and appropriate use of Micatrio® Combination Tablets treatment in patients with hypertension
Amlodipine causes marked coronary and peripheral arterial vasodilation (which leads to plasma leakage in dependent areas since the veins remain constricted). As happens with other dihydropyridine calcium blockers, this results in a small percentage of patients having a problem with pedal edema (Am J Med. 2004;116:35-43). The pedal edema is not related to congestive heart failure and responds only inconsistently to diuretics, but it is not harmful.Mungkin akan nmpk sedikit gemuk sbb berlaku edema/bengkak.. ...
ContentsAmlodipine; diltiazem; felodipine; flunarizineBiggest side effectFull sex driveAdjacent connatural brushHigh blood pressure. ...Blood pressure. ...amlodipine; diltiazem; felodipine; flunarizine; Isradipine; Nicardipine ... shown that CCBs have the potential to cause sexual dysfunction in both men and women. ... This involves maintaining your current level of CCB while adding a second ...…
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