DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureNamed GroupsHealth CareGeographicals
AmlodipineCalcium Channel BlockersAntihypertensive AgentsDihydropyridinesTetrazolesHydrochlorothiazideAzetidinecarboxylic AcidHypertensionValineBlood PressureChlorthalidoneNifedipineLisinoprilDrug Therapy, CombinationAngiotensin II Type 1 Receptor BlockersMibefradilDouble-Blind MethodAtenololBenzimidazolesAngiotensin-Converting Enzyme InhibitorsCross-Over StudiesMaleatesDizocilpine MaleatePerhexilineTimololAdministration, OralHeart RateCatecholaminesZimeldineDrug CombinationsIsosorbide DinitrateIsosorbideNadololPentaerythritol TetranitrateVasodilator AgentsDelayed-Action PreparationsBenzazepinesDizzinessHypotensionUniversal PrecautionsWaterWeatherFumaratesAmidesPharmacistsReninDrugs, EssentialIrelandNorthern IrelandCommerceImidazoles
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Dihydropyridines: Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.TetrazolesHydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.Azetidinecarboxylic Acid: A proline analog that acts as a stoichiometric replacement of proline. It causes the production of abnormal proteins with impaired biological activity.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.Lisinopril: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Angiotensin II Type 1 Receptor Blockers: Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.Mibefradil: A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.Benzimidazoles: Compounds with a BENZENE fused to IMIDAZOLES.Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)MaleatesDizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.Timolol: A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Catecholamines: A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.Zimeldine: One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Isosorbide Dinitrate: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.Isosorbide: 1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.Nadolol: A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor.Pentaerythritol Tetranitrate: A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025)Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Benzazepines: Compounds with BENZENE fused to AZEPINES.Dizziness: An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.Universal Precautions: Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Weather: The state of the ATMOSPHERE over minutes to months.Fumarates: Compounds based on fumaric acid.Amides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)Pharmacists: Those persons legally qualified by education and training to engage in the practice of pharmacy.Renin: A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.Drugs, Essential: Drugs considered essential to meet the health needs of a population as well as to control drug costs.IrelandNorthern IrelandCommerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).

Effects of amlodipine on sympathetic nerve traffic and baroreflex control of circulation in heart failure. (1/462)

Short-acting calcium antagonists exert a sympathoexcitation that in heart failure further enhances an already elevated sympathetic activity. Whether this is also the case for long-acting formulations is not yet established, despite the prognostic importance of sympathetic activation in heart failure. It is also undetermined whether in this condition long-acting calcium antagonists favorably affect a mechanism potentially responsible for the sympathetic activation, ie, the baroreflex impairment. In 28 heart failure patients (NYHA functional class II) under conventional treatment we measured plasma norepinephrine and efferent postganglionic muscle sympathetic nerve activity (microneurography) at rest and during arterial baroreceptor stimulation and deactivation induced by stepwise intravenous infusions of phenylephrine and nitroprusside, respectively. Measurements were performed at baseline and after 8 weeks of daily oral amlodipine administration (10 mg/d, 14 patients) or before and after an 8-week period without calcium antagonist administration (14 patients). Amlodipine caused a small and insignificant blood pressure reduction. Heart rate, left ventricular ejection fraction, and plasma renin and aldosterone concentrations were not affected. This was the case also for plasma norepinephrine (from 2.43+/-0.41 to 2.50+/-0.34 nmol/L, mean+/-SEM), muscle sympathetic nerve activity (from 54.4+/-5.9 to 51.0+/-4.3 bursts/min), and arterial baroreflex responses. No change in the above-mentioned variables was seen in the control group. Thus, in mild heart failure amlodipine treatment does not adversely affect sympathetic activity and baroreflex control of the heart and sympathetic tone. This implies that in this condition long-acting calcium antagonists can be administered without untoward neurohumoral effects anytime conventional treatment needs to be complemented by drugs causing additional vasodilatation.  (+info)

Irbesartan reduces QT dispersion in hypertensive individuals. (2/462)

Angiotensin type 1 receptor antagonists have direct effects on the autonomic nervous system and myocardium. Because of this, we hypothesized that irbesartan would reduce QT dispersion to a greater degree than amlodipine, a highly selective vasodilator. To test this, we gathered electrocardiographic (ECG) data from a multinational, multicenter, randomized, double-blind parallel group study that compared the antihypertensive efficacy of irbesartan and amlodipine in elderly subjects with mild to moderate hypertension. Subjects were treated for 6 months with either drug. Hydrochlorothiazide and atenolol were added after 12 weeks if blood pressure (BP) remained uncontrolled. ECGs were obtained before randomization and at 6 months. A total of 188 subjects (118 with baseline ECGs) were randomized. We analyzed 104 subjects who had complete ECGs at baseline and after 6 months of treatment. Baseline characteristics between treatments were similar, apart from a slight imbalance in diastolic BP (irbesartan [n=53] versus amlodipine [n=51], 99.2 [SD 3. 6] versus 100.8 [3.8] mm Hg; P=0.03). There were no significant differences in BP normalization (diastolic BP <90 mm Hg) between treatments at 6 months (irbesartan versus amlodipine, 80% versus 88%; P=0.378). We found a significant reduction in QT indexes in the irbesartan group (QTc dispersion mean, -11.4 [34.5] milliseconds, P=0.02; QTc max, -12.8 [35.5] milliseconds, P=0.01), and QTc dispersion did not correlate with the change in BP. The reduction in QT indexes with amlodipine (QTc dispersion, -9.7 [35.4] milliseconds, P=0.06; QTc max, -8.6 [33.2] milliseconds, P=0.07) did not quite reach statistical significance, but there was a correlation between the change in QT indexes and changes in systolic BP. In conclusion, irbesartan improved QT dispersion, and this effect may be important in preventing sudden cardiac death in at-risk hypertensive subjects.  (+info)

Low-dose combination therapy as first-line hypertension treatment for blacks and nonblacks. (3/462)

To assess the efficacy and safety of bisoprolol/6.25-mg hydrochlorothiazide (HCTZ), amlodipine, and enalapril in black and nonblack patients, data from two comparative studies were pooled and subgroup analyses performed. Both studies had similar designs and included all three active treatments. The second study also included a placebo group. Subjects (n = 541) with a sitting diastolic blood pressure of 95-114 mmHg were titrated to achieve a diastolic blood pressure < or = 90 mmHg. The studies included 114 blacks and 427 nonblacks. Results of an intention-to-treat analysis of mean change from baseline after 12 weeks of treatment showed the following: 1) blood pressure was significantly lowered by all three active drugs compared with baseline or placebo; 2) in blacks, bisoprolol/6.25-mg HCTZ resulted in significantly greater reductions of systolic and diastolic blood pressure than enalapril or placebo, but was not significantly different from amlodipine; 3) in nonblacks, bisoprolol/6.25-mg HCTZ resulted in significantly greater reduction of diastolic blood pressure than amlodipine, enalapril, or placebo. The placebo-corrected change in blood pressure was greater for blacks than whites on the bisoprolol/6.25-mg HCTZ combination, but this was not statistically significant. Bisoprolol/6.25-mg HCTZ controlled diastolic blood pressure to < or = 90 mmHg in significantly more patients than enalapril or placebo in blacks and nonblacks. The difference in control rates was not significant versus amlodipine. The incidence of drug-related adverse events was similar between treatments; however, bisoprolol/6.25-mg HCTZ had a lower discontinuation rate due to lack of blood pressure control or adverse experiences in both blacks and nonblacks.  (+info)

Renal effects of amlodipine in normotensive renal transplant recipients. (4/462)

Renal effects of amlodipine in normotensive renal transplant recipients. The use of cyclosporin A (CsA) has improved the success of renal transplantation, but is associated with hypertension and significant renal toxicity. Previous reports suggest that calcium channel blockers may be useful in opposing the adverse effects of CsA. We have evaluated the effects of amlodipine (5 mg, once daily for 8 weeks) on renal function in 27 normotensive renal transplant recipients with stable renal function, in a double-blind, placebo-controlled, multicentre, cross over study. Amlodipine significantly reduced serum creatinine concentration relative to placebo (mean+/-SD: 168+/-65 vs 177+/-66 micromol/l; P=0.002) and there was a strong trend towards an increase in effective renal plasma flow on amlodipine relative to placebo (238+/-92 vs 217+/-87 ml/min; P=0.055). Glomerular filtration rate and lithium clearance were unaffected. Trough CsA blood concentration was unaffected. Amlodipine was well tolerated, with a low incidence of adverse events, and did not affect blood pressure or heart rate. In conclusion, amlodipine reduced serum creatinine in normotensive renal transplant recipients after only 8 weeks treatment, and was well tolerated in concomitant administration with CsA.  (+info)

Beneficial effect of myocardial angiogenesis on cardiac remodeling process by amlodipine and MCI-154. (5/462)

The present study examined the effect of long-term treatment with amlodipine and MCI-154 (a Ca2+ sensitizer) on progressive cardiac dysfunction and microvasculature in the dilated cardiomyopathic (DCM) hamster heart. After treatment of DCM hamsters (Bio 53.58) with amlodipine or MCI-154 for 15 wk from the age of 5 wk, amlodipine and MCI-154 were found to cause an increase in left ventricular percent fractional shortening and decreases in left ventricular diastolic dimension and isovolumic relaxation time in echocardiograms (P < 0.01). A hemodynamic study showed that the diastolic time constant decreased in the amlodipine-treatment group (P < 0.05). In a morphometric study employing a double-staining method that discriminated arteriolar and venular capillaries, amlodipine and MCI-154 caused increases in total capillary density (P < 0.05) and the proportion of venular capillaries (P < 0.05). Moreover, Northern blot analysis showed that the expression of mRNA for vascular endothelial growth factor was significantly increased by amlodipine and MCI-154. They preserve coronary microvasculature in the DCM hamster and might induce angiogenesis of small vessels, thereby contributing to preservation of cardiac systolic and diastolic function.  (+info)

Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. (6/462)

BACKGROUND: Angiotensin II activates NAD(P)H-dependent oxidases via AT1-receptor stimulation, the most important vascular source of superoxide (O2*-). The AT1 receptor is upregulated in vitro by low-density lipoprotein. The present study was designed to test whether hypercholesterolemia is associated with increased NAD(P)H-dependent vascular O2*- production and whether AT1-receptor blockade may inhibit this oxidase and in parallel improve endothelial dysfunction. METHODS AND RESULTS: Vascular responses were determined by isometric tension studies, and relative rates of vascular O2*- production were determined by use of chemiluminescence with lucigenin, a cypridina luciferin analogue, and electron spin resonance studies. AT1-receptor mRNA was quantified by Northern analysis, and AT1-receptor density was measured by radioligand binding assays. Hypercholesterolemia was associated with impaired endothelium-dependent vasodilation and increased O2*- production in intact vessels. In vessel homogenates, we found a significant activation of NADH-driven O2*- production in both models of hyperlipidemia. Treatment of cholesterol-fed animals with the AT1-receptor antagonist Bay 10-6734 improved endothelial dysfunction, normalized vascular O2*- and NADH-oxidase activity, decreased macrophage infiltration, and reduced early plaque formation. In the setting of hypercholesterolemia, the aortic AT1 receptor mRNA was upregulated to 166+/-11%, accompanied by a comparable increase in AT1-receptor density. CONCLUSIONS: Hypercholesterolemia is associated with AT1-receptor upregulation, endothelial dysfunction, and increased NADH-dependent vascular O2*- production. The improvement of endothelial dysfunction, inhibition of the oxidase, and reduction of early plaque formation by an AT1-receptor antagonist suggests a crucial role of angiotensin II-mediated O2*- production in the early stage of atherosclerosis.  (+info)

Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure. (7/462)

BACKGROUND: Inhibition of angiotensin-converting enzyme (ACE) reduces the risk of cardiovascular problems in patients with chronic renal failure. This effect may be due in part to a decrease in sympathetic nervous activity, but no direct evidence of such an action is available. METHODS: We studied muscle sympathetic-nerve activity in 14 patients with hypertension, chronic renal failure, and increased plasma renin activity before, during, and after administration of the ACE inhibitor enalapril. Ten other patients with similar clinical characteristics were studied before and during treatment with the calcium-channel blocker amlodipine. Normal subjects matched for age and weight were included in both studies. RESULTS: At base line, mean (+/-SD) muscle sympathetic-nerve activity was higher in the group of patients who received enalapril than in the control subjects (35+/-17 vs. 19+/-9 bursts per minute, P=0.004). The baroreflex curve, which reflects changes in muscle sympathetic-nerve activity caused by manipulations of blood pressure with sodium nitroprusside and phenylephrine, was shifted to the right in the patients, but baroreflex sensitivity was similar to that in the control subjects (-2.1+/-1.9 and -2.7+/-1.3 bursts per minute per mm Hg, respectively; P=0.36). A single dose of the sympatholytic drug clonidine caused a greater fall in blood pressure in the patients than in the control subjects. Treatment with enalapril normalized blood pressure and muscle sympathetic-nerve activity (at 23+/-10 bursts per minute) in the patients and shifted the baroreflex curve to the left, reflecting normal blood-pressure levels, without significantly changing sensitivity (-2.3+/-1.8 bursts per minute per mm Hg, P=0.96). In the patients who received amlodipine, treatment also lowered blood pressure but increased muscle sympathetic-nerve activity, from 41+/-19 to 56+/-14 bursts per minute (P=0.02). CONCLUSIONS: Increased sympathetic activity contributes to hypertension in patients with chronic renal disease. ACE inhibition controls hypertension and decreases sympathetic hyperactivity.  (+info)

Combination of calcium channel blockers and beta-adrenoceptor blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers. Netherlands Working Group on Cardiovascular Research (WCN). (8/462)

AIMS: The combination of calcium channel blockers and beta-adrenoceptor blockers is more effective for the treatment of exercise-induced angina pectoris than beta-adrenoceptor blocker monotherapy. As ischaemia in exercise-induced angina is preceded by increase in heart rate, calcium channel blockers with negative chronotropic properties may perform better for this purpose than nonchronotropic compounds. METHODS: A 335 patient double-blind parallel-group study comparing 14 day treatment with amlodipine 5 and 10 mg, with diltiazem 200 and 300 mg, and mibefradil 50 and 100 mg added to baseline beta-adrenoceptor blocker treatment was performed. Exercise testing (ETT) was performed by bicycle ergometry. RESULTS: Although none of the calcium channel blockers improved duration of exercise or amount of workload, all significantly delayed onset of 1 mm ST-segment depression on ETT (P<0.001 for any treatment vs baseline). In addition, mibefradil, both low and high dose treatment, produced the longest delays (low dose: different from diltiazem and amlodipine by 24.1 and 29.8 s, respectively, P<0. 003 and <0.001; high dose: different from diltiazem and amlodipine by 33.7 and 37.0 s, respectively, P<0.001 and <0.001). These effects were linearly correlated with the reduction in rate pressure product (RPP). Serious symptoms of dizziness occurred significantly more frequently on mibefradil (P<0.05), and 19 patients on mibefradil withdrew from trial. CONCLUSIONS: Calcium channel blockers with negative chronotropic properties provide greater delay of ischaemia in patients with exercise-induced angina, but the concomitant risk of intolerable dizziness attenuates this benefit.  (+info)

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Cadila Pharmaceuticals is a one of the foremost pharma companies in synthesizing APIs. We are bulk drug manufacturer of Amlodipine Besylate. The CAS number of Amlodipine Besylate is 88150-42-9.. Amlodipine is used to treat high blood pressure. Lowering high blood pressure helps to prevent heart attack, strokes and kidney problems. Amlodipine Besylate is a calcium channel blocker drug. It relaxes blood vessels so blood can flow easily. It is also used to prevent certain types of chest pain.. Cadila Pharmaceuticals Limited is one of the top USFDA approved pharmaceutical companies based in India. It is respected as a best Active Pharmaceutical Ingredients (APIs) manufacturing company in India. One of our core expertises is to synthesize APIs of the highest quality at inexpensive price.. We are major Amlodipine Besylate manufacturer and supplier. We export Amlodipine Besylate to Asian countries like; Japan, China, Georgia, Singapore, Malaysia, Vietnam, South Korea etc., and Middle East countries ...
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Atrial Fibrillation: Amlodipine/Atorvastatin 5 Mg-20 Mg ORAL TABLET vs Amlodipine/Atorvastatin 5 Mg-10 Mg ORAL TABLET vs...Atrial Fibrillation: Amlodipine/Atorvastatin 5 Mg-20 Mg ORAL TABLET vs Amlodipine/Atorvastatin 5 Mg-10 Mg ORAL TABLET vs...
1. Study name: Intensive management of blood pressure and cholesterol in elderly Chinese with hypertension and atrial fibrillation (IMPRESSION) 2. Medicine: amlodipine/atorvastatin (5/10mg tablet); amlodipine/atorvastatin (5/20mg tablet); allisartan (240mg/tablet). 3. Rationale: controlling blood pressure and cholesterol are both effective means to reduce cardiovascular risks, however, it is still unknown whether high cardiovascular risk patients with atrial fibrillation would benefit from intensive management of blood pressure and cholesterol. 4. Objective: To evaluate the efficacy and safety of intensive management of blood pressure and cholesterol. 5. Study design: This study is a multi-center, randomized and controlled clinical trial with four equally sized treatment groups: amlodipine/atorvastatin (5/10mg tablet); amlodipine/atorvastatin (5/20mg tablet); amlodipine
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Efficacy and Duration of Benazepril Plus Amlodipine or Hydrochlorthiazide on 24-Hour Ambulatory Systolic Blood Pressure Control...Efficacy and Duration of Benazepril Plus Amlodipine or Hydrochlorthiazide on 24-Hour Ambulatory Systolic Blood Pressure Control...
The combination of benazepril plus amlodipine was shown to be more effective than benazepril plus hydrochlorothiazide in reducing cardiovascular events in the Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial. There was a small difference in clinic systolic blood pressure between the treatment arms favoring benazepril plus amlodipine. Ambulatory blood pressure monitoring provides a more rigorous estimate of blood pressure effects. A subset of 573 subjects underwent ambulatory blood pressure monitoring during year 2. Readings were obtained every 20 minutes during a 24-hour period. Between-treatment differences (benazepril plus amlodipine versus benazepril plus hydrochlorothiazide) in mean values were analyzed using ANOVA. Treatment comparisons with respect to categorical variables were made using Pearsons χ2. At year 2, the treatment groups did not differ significantly in 24-hour mean daytime or nighttime blood pressures ...
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International open-label studies to assess the efficacy and safety of single-pill amlodipine/atorvastatin in attaining blood...International open-label studies to assess the efficacy and safety of single-pill amlodipine/atorvastatin in attaining blood...
BACKGROUND: Single-pill amlodipine/atorvastatin targets the two most common modifiable cardiovascular risk factors, hypertension and dyslipidaemia. We evaluated the clinical utility of this single pill to help patients across Europe and Canada achieve country-specific targets for blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C). DESIGN: Two 16-week, open-label studies conducted in 122 study centres across the United Kingdom and Canada (JEWEL 1) and 113 centres across 11 European countries (JEWEL 2). METHODS: Patients with uncontrolled BP and controlled/uncontrolled LDL-C qualifying for treatment according to local governing guidelines were administered single-pill amlodipine/atorvastatin with appropriate lifestyle modification. Eight dosages of amlodipine/atorvastatin (5/10-10/80-mg) were titrated to achieve country-specific BP and LDL-C targets. The primary outcome was the percentage of patients reaching country-specific BP and LDL-C targets in 16 weeks. RESULTS: Among 2245 patients
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There are several generics of Amlodipine besylate tablets locally manufactured by some Syrian pharmaceutical companies. this study tries to evaluate the pharmaceutical and chemical equivalence of amlodipine besylate tablets from 5 Syrian pharmaceuticals and comparison the results with an innovator (Norvasc®). The pharmaceutical equivalence and the quality for each generic were assessed through the evaluation of standard tests such as uniformity of weight, friability, hardness, disintegration, content uniformity, uniformity of dosage units and dissolution rate. The assay was conducted by using HPLC (the analytical column was C 18, 150 x 4.6 mm I.D, 4µm particle size, the mobile phase was a mixture of 30% acetonitrile and 70% 100 mM ammonium acetate pH 5 with flow rate of 1ml/min and UV detection at 237 nm for amlodipine). All the generics complied with the standard specifications for uniformity of weight (|±7.5%), friability (|1%), content uniformity (85-115%), uniformity of dosage units (|15),
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Amlodipine. No evidence of teratogenicity or other embryo/fetal toxicity was found when pregnant rats and rabbits were treated orally with amlodipine maleate at doses of up to 10 mg amlodipine/kg/day (respectively about 10 and 20 times the maximum recommended human dose of 10 mg amlodipine on a mg/m2 basis) during their respective periods of major organogenesis. (Calculations based on a patient weight of 60 kg). However, litter size was significantly decreased (by about 50%) and the number of intrauterine deaths was significantly increased (about 5-fold) in rats receiving amlodipine maleate at a dose equivalent to 10 mg amlodipine/kg/day for 14 days before mating and throughout mating and gestation. Amlodipine maleate has been shown to prolong both the gestational period and the duration of labor in rats at this dose. There are no adequate and well-controlled studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the ...
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Abstract 16093: Effects of Aliskiren and Amlodipine Combination Treatment on Endothelial Nitric Oxide and Peroxynitrite Release...Abstract 16093: Effects of Aliskiren and Amlodipine Combination Treatment on Endothelial Nitric Oxide and Peroxynitrite Release...
Background: Endothelial cell (EC) dysfunction is causally related to atherosclerosis and hypertension. Aliskiren, a direct renin inhibitor, and amlodipine, a calcium channel blocker, have each been shown to improve vascular function; however, their combined effects are not understood. In this study, we tested the separate versus combined effects of aliskiren and amlodipine on aortic and glomerular EC function.. Methods: Spontaneously hypertensive (SH) rats were assigned to four treatment groups: (1) vehicle; (2) 40 mg/kg/day aliskiren; (3) 5 mg/kg/day amlodipine; and (4) combined aliskiren and amlodipine treatment (at 40 and 5 mg/kg/day, respectively). Each group contained 8 animals and treatments were administered for 8 weeks. Endothelial nitric oxide (NO) and peroxynitrite (ONOO-) release from aortic and glomerular ECs were measured ex vivo using amperometric nanosensors and correlated with systemic blood pressure (BP) measurements.. Results: Aliskiren and amlodipine improved NO release in a ...
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METHODS: Twelve mild-to-moderate essential hypertensives were investigated in this open, randomized cross-over study. Blood pressure and heart rate were measured by use of ambulatory blood pressure monitoring after a wash-out period of 1 week and after treatment schedules with 5 mg amlodipine once a day either. Amlodipine is a calcium channel blocker that dilates blood vessels and improves blood flow. Amlodipine is used to treat chest pain (angina) and other conditions caused by coronary artery disease. Amlodipine is also used to treat high blood pressure. It does not matter what time of day you take amlodipine.. You may have to take what time of day should i take amlodipine blood pressure medicine for the breakdown of your life. If estoque blood pressure is not treated, it can cure serious problems such as other failure, blood pressure disease, stroke, or kidney disease. You may take this morning with or without food. Take this medicine at the same situation each day. Their doctor will discuss ...
Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure - Full Text View - ClinicalTrials.govInfluence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure - Full Text View - ClinicalTrials.gov
Patients with end-stage renal failure have a markedly higher mortality because of cardiovascular events in comparison with the normal population. Disorders in the calcium metabolism, such as calcification of the vessel walls, occur very frequently. There are indications that calcium channel blockers are capable of lowering the cardiovascular mortality in patients with end-stage renal failure.. It is intended to carry out a prospective, randomized, double-blind, placebo-controlled, multicenter study in order to find out if the calcium channel blocker amlodipine is able to reduce the mortality of patients with end-stage renal failure.. The investigation will be carried out after suitable explanation and written informed consent in 356 patients aged between 18 and 90 years with end-stage renal failure and chronic haemodialysis treatment. The patients will be randomized to either treatment with amlodipine 10 mg/day or placebo. The occurrence of events will be documented and evaluated prospectively ...
Effects of amlodipine on circadian rhythms in blood pressure, heart rate, and motility: a telemetric study in rats.Effects of amlodipine on circadian rhythms in blood pressure, heart rate, and motility: a telemetric study in rats.
In male Wistar rats [light(L): 07:00-19:00 h, dark(D): 19:00-07:00 h], the effects of the calcium channel blocker amlodipine (1, 3, 10 mg/kg i.p.) on blood pressure, heart rate, and motor activity were studied by telemetric monitoring. Amlodipine was
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TY - JOUR. T1 - Pharmacokinetic and haemodynamic interactions between amlodipine and losartan in human beings. AU - Park, Jin Woo. AU - Kim, Kyoung Ah. AU - Il Kim, Yong. AU - Park, Ji Young. PY - 2019/10/1. Y1 - 2019/10/1. N2 - The combination of calcium channel blockers (CCB) and angiotensin receptor blockers (ARB) for the treatment of hypertension showed improved efficacy and safety. Amlodipine is mainly metabolized by cytochrome P450 (CYP) 3A4, whereas losartan is metabolized by CYP2C9 and CYP3A4. The potential pharmacokinetic interactions between amlodipine and losartan were assessed. An open-label, three-period, fixed-sequence trial was conducted. Amlodipine, losartan and combined amlodipine and losartan were administered to 24 healthy male participants during periods 1, 2 and 3, respectively, for 9 days each. The pharmacokinetics of amlodipine, losartan and EXP-3174, an active metabolite of losartan, were assessed at steady-state. Twenty participants completed the study without serious ...
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Azelnidipine plus olmesartan versus amlodipine plus olmesartan on arterial stiffness and cardiac function in hypertensive patients: a randomized trial Takeshi Takami,1 Yoshihiko Saito21Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan; 2First Department of Internal Medicine, Nara Medical University, Kashihara, JapanPurpose: To compare the long-term effects of olmesartan combined with either azelnidipine or amlodipine on central blood pressure (CBP), left ventricular (LV) mass index (LVMI), LV diastolic function (e´ velocity, E/e´ ratio, E/A ratio) and arterial stiffness (brachial-ankle pulse wave velocity [baPWV] and augmentation index normalized for a heart rate of 75 bpm [AIx]).Patients and methods: Patients with systolic BP ≥140 mmHg and/or diastolic BP ≥ 90 mmHg received olmesartan monotherapy (20 mg/day) for 12 weeks. They were then randomly assigned to fixed-dose add-on therapy with azelnidipine (16 mg/day; n = 26) or amlodipine (5 mg/day; n = 26) for a further 2 years. CBP,
Decreased blood viscosity and serum levels of erythropoietin after anti-hypertensive treatment with amlodipine or metoprolol :...Decreased blood viscosity and serum levels of erythropoietin after anti-hypertensive treatment with amlodipine or metoprolol :...
The increased viscosity of blood of hypertensive patients can be assumed to be a risk factor for the development of cardiovascular diseases. The aim of the present study was to elucidate whether anti-hypertensive treatment has any impact on blood theology.. Twenty patients with previously untreated hypertension who consecutively attended our outpatient hypertension clinic were included in this prospective, open, cross-over study. The patients were randomly selected to treatment with amlodipine or metoprolol. The antihypertensive therapy was switched after 4 months. Haemorheological and haemodynamic variables were measured with rotational viscometry and impedance cardiography, respectively.. Fifteen and 16 patients could be evaluated after amlodipine or metoprolol treatment respectively. The mean blood pressure (BP) decreased from 159 +/- 22/105 +/- 7 to 139 +/- 21/91 +/- 6 mm Hg on amlodipine and from 162 +/- 22/104 +/- 5 to 145 +/- 24/90 +/- 8 mm Hg on metoprolol therapy. After amlodipine ...
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MassHealth Drug List - Health and Human ServicesMassHealth Drug List - Health and Human Services
SmartPA: Claims for amlodipine/atorvastatin at a quantity of ≤ 30 units/month will usually process at the pharmacy without a PA request if the member has a history of paid MassHealth pharmacy claims for 90 days out of the last 120 days of the requested agent, or has a history of paid MassHealth pharmacy claims for rosuvastatin at a dose of at least 40 mg for at least three months in all claims history.†. amlodipine/olmesartan, amlodipine/olmesartan/hydrochlorothiazide, amlodipine/telmisartan, amlodipine/valsartan/hydrochlorothiazide, Byvalson, candesartan/hydrochlorothiazide, captopril/hydrochlorothiazide, Edarbyclor, olmesartan/hydrochlorothiazide, Prestalia, Tekturna HCT, telmisartan/hydrochlorothiazide, trandolapril/verapamil. ...
MassHealth Drug List - Health and Human ServicesMassHealth Drug List - Health and Human Services
SmartPA: Claims for amlodipine/atorvastatin at a quantity of ≤ 30 units/month will usually process at the pharmacy without a PA request if the member has a history of paid MassHealth pharmacy claims for 90 days out of the last 120 days of the requested agent, or has a history of paid MassHealth pharmacy claims for rosuvastatin at a dose of at least 40 mg for at least three months in all claims history.†. amlodipine/olmesartan, amlodipine/olmesartan/hydrochlorothiazide, amlodipine/telmisartan, amlodipine/valsartan/hydrochlorothiazide, Byvalson, candesartan/hydrochlorothiazide, captopril/hydrochlorothiazide, Edarbyclor, olmesartan/hydrochlorothiazide, Prestalia, Tekturna HCT, telmisartan/hydrochlorothiazide, trandolapril/verapamil. ...
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Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow. Perindopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Perindopril also widens blood vessels and also prevents the body from retaining water. Amlodipine and perindopril is a combination...
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Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow. Perindopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Perindopril also widens blood vessels and also prevents the body from retaining water. Amlodipine and perindopril is a combination...
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Efficacy/Safety of Valsartan Plus Amlodipine and Amlodipine Alone in Patients With Hypertension - Tabular View - ClinicalTrials...Efficacy/Safety of Valsartan Plus Amlodipine and Amlodipine Alone in Patients With Hypertension - Tabular View - ClinicalTrials...
Women of child-bearing potential (WOCBP), defined as all women physiologically capable of becoming pregnant, including women whose career, lifestyle, or sexual orientation precluded intercourse with a male partner and women whose partners had been sterilized by vasectomy or other means, UNLESS they met the following definition of post-menopausal: 12 months of natural (spontaneous) amenorrhea or 6 months of spontaneous amenorrhea with serum follicle stimulating hormone (FSH) levels , 40 mIU/m or 6 weeks post-surgical bilateral oophorectomy with or without hysterectomy OR were using one or more of the following acceptable methods of contraception: surgical sterilization (e.g., bilateral tubal ligation, vasectomy), and double-barrier methods (any double combination of: intra-uterine device [IUD], male or female condom with spermicidal gel, diaphragm, sponge, cervical cap). Acceptable methods of contraception included total abstinence at the discretion of the investigator in cases where the age, ...
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In the investigation of Pumpkin seed oil and it effects on cardiovascular diseases indicated that after Pumpkin seed oil (40 or 100?mg/kg), amlodipine (0.9?mg/kg), or vehicle (control) was given once daily orally for 6 weeks, l-NAME administration resulted in a significant increase in BP starting from the second week. Pumpkin seed oil or amlodipine treatment significantly reduced the elevation in BP by l-NAME(nitro-l-arginine methyl ester hydrochloride) and normalized the l-NAME-induced ECG(electrocardiogram ) changes?namely, prolongation of the RR interval, increased P wave duration, and ST elevation. Both treatments significantly decreased the elevated levels of MDA(plasma malondialdehyde) and reversed the decreased levels of NO(serum nitric oxide) metabolites to near normal values compared with the l-NAME-treated group according to the study of "Antihypertensive and Cardioprotective Effects of Pumpkin Seed Oil" by El-Mosallamy AE, Sleem AA, Abdel-Salam OM, Shaffie N, Kenawy SA.(a ...
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Olmesartan Medoxomil/Amlodipine/HydrochlorothiazideOlmesartan Medoxomil/Amlodipine/Hydrochlorothiazide
... is a drug prescribed to treat high blood pressure. This eMedTV selection takes an in-depth look at this medication, including details on how it works, dosing guidelines, potential side effects, and more.
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide - FDA prescribing information, side effects and usesOlmesartan Medoxomil, Amlodipine and Hydrochlorothiazide - FDA prescribing information, side effects and uses
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Life Insurance for Caduet (Amlodipine/Atorvastatin) Users. Everything You Need to Know at a Glance!Life Insurance for Caduet (Amlodipine/Atorvastatin) Users. Everything You Need to Know at a Glance!
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Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac...Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac...
OBJECTIVE: This study aims to establish the benefits of lowering cholesterol in diabetic patients with well-controlled hypertension and average/below-average cholesterol concentrations, but without established coronary disease. RESEARCH DESIGN AND METHODS: In the lipid-lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-LLA), 10,305 hypertensive patients with no history of coronary heart disease (CHD) but at least three cardiovascular risk factors were randomly assigned to receive 10 mg atorvastatin or placebo. Effects on total cardiovascular outcomes in 2,532 patients who had type 2 diabetes at randomization were compared. RESULTS: During a median follow-up of 3.3 years, concentrations of total and LDL cholesterol among diabetic participants included in ASCOT-LLA were approximately 1 mmol/l lower in those allocated atorvastatin compared with placebo. There were 116 (9.2%) major cardiovascular events or procedures in the atorvastatin group and 151 (11.9%) events in the placebo group
CiNii è«–æ–‡ - Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Nerve...CiNii è«–æ–‡ - Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Nerve...
The effect of long−term treatment with dihydropyridine calcium antagonists(amlodipine, pranidipine, nicardipine)on the periarterial nerve function was investigated in the perfused mesenteric vascular bed isolated from spontaneously hypertensive rat(SHR).Male 8−week−old SHR received amlodipine(0.01% and 0.02%)and nicardipine(0.1%)in drinking water and pranidipine(0.0035% and 0.035%)in rat chow for 7 weeks.Mean blood pressure in SHR was significantly lowered by long−term treatment with each calcium antagonist.In mesenteric vascular preparations treated with each calcium antagonist, vasoconstriction induced by periarterial nerve stimulation(PNS;4, 8 and 12 Hz)was significantly smaller than that in non−treated SHR.The PNS(8 Hz)−evoked norepinephrine(NE)overflow in the perfusate was significantly decreased by amlodipine and pranidipine treatment, whereas nicardipine−treatment significantly enhanced the overflow of NE.In preparations with active tone produced by methoxamine and ...
Genéricos Tribenzor (Olmesartan, Amlodipine And Hydrochlorothiazide 20mg + 5mg + 12.5/40mg + 5mg + 12.5mg) € 1.93 comprimido -...Genéricos Tribenzor (Olmesartan, Amlodipine And Hydrochlorothiazide 20mg + 5mg + 12.5/40mg + 5mg + 12.5mg) € 1.93 comprimido -...
Tribenzor contém uma combinação de anlodipina, hidroclorotiazida e olmesartana. Anlodipina é um bloqueador dos canais de cálcio que relaxa (amplia) os vasos sanguíneos e melhora o fluxo sanguíneo. Hidroclorotiazida é um diurético tiazídico (pílula de água) que ajuda a evitar a absorção excessiva de sal pelo organismo, o que pode causar retenção de líquidos. Olmesartana é um bloqueador do receptor da angiotensina II que previne o estreitamento dos vasos sanguíneos, reduzindo assim a pressão arterial e melhorando o fluxo sanguíneo. Tribenzor é utilizado no tratamento da pressão arterial elevada (hipertensão). . Genéricos Tribenzor (Olmesartan, Amlodipine And Hydrochlorothiazide 20mg + 5mg + 12.5/40mg + 5mg + 12.5mg) € 1.93 comprimido - Doenças Cardiovasculares, Hipertensão Arterial, Trato Urinário @ Canadian online pharmacy. Cheap Canadian online pharmacy
Amturnide (Aliskiren, Amlodipine and Hydrochlorothiazide Tablets): Side Effects, Interactions, Warning, Dosage & UsesAmturnide (Aliskiren, Amlodipine and Hydrochlorothiazide Tablets): Side Effects, Interactions, Warning, Dosage & Uses
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Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE...Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE...
Julius S, Kjeldsen SE, Weber M, Brunner HR, Ekman S, Hansson L, Hua T, Laragh J, McInnes GT, Mitchell L, Plat F, Schork A, Smith B, Zanchetti A, VALUE trial group. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet. 2004; 363(9426): 2022-31 ...
The Special Drug Use-results Survey on Long-term Use of Telmisartan 80 mg/Amlodipine 5 mg/Hydrochlorothiazide 12.5 mg Fixed...The Special Drug Use-results Survey on Long-term Use of Telmisartan 80 mg/Amlodipine 5 mg/Hydrochlorothiazide 12.5 mg Fixed...
Study to evaluate real-world safety, effectiveness and appropriate use of Micatrio® Combination Tablets treatment in patients with hypertension
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Amlodipine - not a significant contributor to clopidogrel non-response? | HeartAmlodipine - not a significant contributor to clopidogrel non-response? | Heart
The current study by Li et al1 examines the pharmacodynamic interaction of amlodipine and clopidogrel. Dual antiplatelet therapy with aspirin and clopidogrel is standard of care for patients with coronary stenting and acute coronary syndromes, although newer, more potent P2Y12 inhibitors such as prasugrel and ticagrelor have recently become available. Clopidogrel is a prodrug that is metabolised in a two-step process by cytochrome P450 (CYP) and esterases to its principal metabolites (figure 1).2 Large interpatient variability has been observed in pharmacodynamic studies of clopidogrel response and pharmacokinetic studies measuring active clopidogrel thiol metabolites. Among the CYP450 isoforms, CYP2C19, CYP3A4, CYP2C9 and CYP2B6 have been identified as being involved in the second step of 2-oxo clopidogrel metabolism and active thiol formation. A variety of esterases are thought to mediate inactivation of parent clopidogrel and metabolites, thus influencing the availability of active thiol ...
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Efficacy and Duration of Benazepril Plus Amlodipine or Hydrochlorthiazide on 24-Hour Ambulatory Systolic Blood Pressure Control...Efficacy and Duration of Benazepril Plus Amlodipine or Hydrochlorthiazide on 24-Hour Ambulatory Systolic Blood Pressure Control...
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DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureNamed GroupsHealth CareGeographicals
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HypertensionTabletsCalcium channelDosageAnginaOlmesartanMedicationHCTZEnalaprilInteract with amlodipineLosartanCADUETCoronarySide effectsActive ingredientTreated with amlodipine besylateInteractionsDosesNauseaCase of amlodipineLevels of amlodipineSensitivity to amlodipinePharmacokinetics of amlodipineTake amlodipineHydrochlorothiazideAnginaNorvasc10mgOlmesartanAntihypertensiveExforgeBenazeprilTelmisartanEffects of amlodipineDoseOralPrecautionsPrescribe amlodipine to treatEfficacyDrugsMedicationsEquivalent to 5 mgCalcium antagonistDoctors prescribe amlodipineCaduetStop taking amlTablet of amlodipineSafety of amlodipineDosage for amlodipineValsartan and amlodipineAliskiren and AmlodipineDrugSimvastatinOrder amlodipineContains amlodipineHigh blood prAllergic reactionAtorvastatin calciumArterial50mgAntagonistsCombinationBlood pressurePerindopril
Hypertension5
Tablets9
Calcium channel2
  • You are sensitive to, or have had an allergic reaction to, amlodipine, other calcium channel blockers, or any of the ingredients listed at the end of this leaflet. (news-medical.net)
  • Amlodipine belongs to a group of drugs called calcium channel blockers, which help relax blood vessels. (rxwiki.com)
Dosage5
  • Ali NW, Abdelwahab NS, Zaki MM, Abdelkawy M (2012) Validated Chromatographic Methods for Simultaneous Determination of Amlodipine Besylate and Perindopril Arginine in Binary Mixtures and in Pharmaceutical Dosage Form. (omicsonline.org)
  • You can buy Amlodipine besylate in two different Amlodipine shops Online from HealthExpress: The dosage prescribed depends on your medical condition and your response to the Amlodipine shop Online. (efyca.net)
  • It's likely that you'll Amlodipine shop Online on a lower dosage, which will increase depending on its effectiveness as well as any possible side effects you experience. (efyca.net)
  • The maximum dosage of Amlodipine which you can take each day is 10mg. (efyca.net)
  • It's more likely you'll develop side effects when taking Amlodipine 10mg because the dosage is high, which is why quantities are gradually increased. (efyca.net)
Angina5
  • In patients with exertional angina, amlodipine reduces the total peripheral resistance (afterload) against which the heart works and reduces the rate pressure product, and thus myocardial oxygen demand, at any given level of exercise. (nih.gov)
  • This inhibition of coronary spasm is responsible for the effectiveness of amlodipine in vasospastic (Prinzmetal's or variant) angina. (nih.gov)
  • Amlodipine is not for the relief of a sudden attack of angina. (news-medical.net)
  • Amlodipine is a prescription medication used to treat high blood pressure and chest pain (angina). (rxwiki.com)
  • When you first start taking amlodipine or increase your dose, you may have a heart attack or worsened angina. (rxwiki.com)
Olmesartan6
Medication3
HCTZ1
Enalapril3
  • Role of TGF-β1/Smads pathway in carotid artery remodeling in renovascular hypertensive rats and prevention by Enalapril and Amlodipine. (lktlabs.com)
  • The calcium channel blocker amlodipine decreases the risk of cardiovascular events (such as heart attack or heart-disease related deaths) in patients with coronary artery disease and normal blood pressure, as does the ACE inhibitor enalapril, but to a lesser extent, according to a study in the November 10 issue of JAMA. (eurekalert.org)
  • Steven E. Nissen, M.D., of the Cleveland Clinic Lerner School of Medicine, Cleveland, and colleagues examined the effects of antihypertensive drugs in 1,991 patients with CAD and normal blood pressure in the Comparison of Amlodipine vs. Enalapril to Limit Occurrences of Thrombosis (CAMELOT) study, a double-blind, randomized, multicenter 24-month trial (enrollment April 1999-April 2002). (eurekalert.org)
Interact with amlodipine2
Losartan9
CADUET1
Coronary2
Side effects5
  • This is not a complete list of amlodipine side effects. (rxwiki.com)
  • stop taking the Amlodipine and what side effects of stopping should Iwatch for? (healthcaremagic.com)
  • Using any type of prescription Amlodipine shop Online means that you could potentially develop side effects, though the majority of people take Amlodipine besylate without complication. (efyca.net)
  • The more Amlodipine shop Online side effects that patients sometimes experience include: Dizziness or light-headedness Persistent, dry coughs Swelling of the hands, feet or ankles You should consult your doctor immediately if you experience any signs of a strong reaction such as a rash, swelling of the mouth or difficulty swallowing or breathing. (efyca.net)
  • Taking high doses of Simvastatin with Amlodipine can increase the risk of developing side effects, such as muscle pain and cramps. (efyca.net)
Active ingredient2
Treated with amlodipine besylate1
Interactions1
Doses2
Nausea1
  • www.immobiliaredicecca.it could include darker Amlodipine shop Online, fainting, slow or irregular heartbeat or persistent nausea, vomiting and diarrhoea, Amlodipine Shop Online. (efyca.net)
Case of amlodipine1
  • In the case of amlodipine there are no specific foods that you must exclude from your diet when receiving amlodipine. (rxwiki.com)
Levels of amlodipine1
  • Steady-state plasma levels of amlodipine are reached after 7 to 8 days of consecutive daily dosing. (nih.gov)
Sensitivity to amlodipine1
Pharmacokinetics of amlodipine1
  • The pharmacokinetics of amlodipine are not significantly influenced by renal impairment. (nih.gov)
Take amlodipine14
Hydrochlorothiazide13
Angina16
Norvasc8
10mg1
Olmesartan8
Antihypertensive4
  • The drug combination aliskiren/amlodipine (INNs, trade name Tekamlo) is an antihypertensive. (wikipedia.org)
  • These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including amlodipine and the ARB class to which valsartan principally belongs. (rxlist.com)
  • Patients not adequately controlled on a single antihypertensive agent may benefit from the addition of amlodipine, which has been used in combination with a thiazide diuretic, beta adrenoreceptor blocking agent or an angiotensin converting enzyme inhibitor. (healthdirect.gov.au)
  • The Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial found similar rates of cardiovascular disease in 4,703 hypertensive patients randomised to either candesartan or amlodipine. (pulsetoday.co.uk)
Exforge3
Benazepril8
Telmisartan6
Effects of amlodipine7
Dose13
  • Your doctor will probably start you on a low dose of amlodipine and gradually increase your dose. (medlineplus.gov)
  • What is the dose of amlodipine and how often should I take it? (netdoctor.co.uk)
  • The usual dose of amlodipine for adults is 5mg taken once a day. (netdoctor.co.uk)
  • You can take your amlodipine dose at any time of day, but try to take it at the same time each day, as this will help you to remember it. (netdoctor.co.uk)
  • Elderly patients and patients with hepatic insufficiency have decreased clearance of amlodipine with a resulting increase in AUC of approximately 40-60%, and a lower initial dose may be required. (nih.gov)
  • Pharmacokinetics and bioequivalence evaluation of two formulations of 10-mg amlodipine besylate: an open-label, single-dose, randomized, two-way crossover study in healthy chinese male volunteers," Clinical Therapeutics , vol. 31, no. 4, pp. 777-783, 2009. (hindawi.com)
  • In a series of 150 cardiac patients, it was found that amlodipine at a dose of 5 mg/day can not induce gingival hyperplasia even if taken more than 6 months (6). (isciii.es)
  • Our patient had a favorable oral condition and received a rather low-dose of amlodipine for only two months. (isciii.es)
  • those of amlodipine are a mixture of dose-dependent phenomena (primarily peripheral edema) and dose-independent phenomena, the former much more common than the latter. (rxlist.com)
  • Amlodipine will be administered as a single daily dose. (clinicaltrials.gov)
  • The recommended adult starting dose of amlodipine is 5 mg taken once daily. (medbroadcast.com)
  • Where to buy generic nolvadex cefadroxila 500mg preco cefadroxil uti dosage cefadroxilo suspension 250 mg 5 ml amlodipine 5mg for sale cefadroxil 500 mg dose. (bridgeartfair.com)
  • The usual dose of can amlodipine be given twice daily gynaecomastia and adefovir diphosphate and prostaglandins. (imagenenaccion.org)
Oral7
Precautions1
Prescribe amlodipine to treat2
Efficacy1
  • Null Hypothesis There is no difference between the efficacy of chelation plus amlodipine therapy and chelation therapy alone in retarding the rate of myocardial iron deposition in thalassemia patients with iron overload and a constant transfusion need. (clinicaltrials.gov)
Drugs6
Medications8
Equivalent to 5 mg1
Calcium antagonist1
Doctors prescribe amlodipine1
Caduet3
  • The STEPS department on amlodipine/atorvastatin (Caduet) in the March 15, 2006, issue of American Family Physician , 1 contains several misleading statements that contradict available evidence. (aafp.org)
  • 1. Wilson SA, Sanford A. Amlodipine/atorvastatin (Caduet) for preventing heart disease [STEPS]. (aafp.org)
  • However, they do not change our conclusion that there is no compelling reason to favor combination therapy with amlodipine/atorvastatin (Caduet) for the prevention of heart disease. (aafp.org)
Stop taking aml2
Tablet of amlodipine2
Safety of amlodipine1
  • According to the FDA, researchers have used clinical trials to evaluate the safety of amlodipine in over 11,000 people . (medicalnewstoday.com)
Dosage for amlodipine2
Valsartan and amlodipine1
Aliskiren and Amlodipine1
  • Neither did it submit studies that would have been relevant to an assessment of the fixed combination of aliskiren and amlodipine versus the appropriate comparator therapy specified by the G-BA. (redorbit.com)
Drug17
Simvastatin3
Order amlodipine3
Contains amlodipine3
High blood pr5
Allergic reaction1
Atorvastatin calcium1
Arterial3
50mg1
Antagonists2
Combination3
Blood pressure4
  • Amlodipine and valsartan is usually given after other blood pressure medicines have been tried without success. (pardeehospital.org)
  • In contrast, systolic pressure measured by brachial cuff averaged 0.7 mm Hg lower in the amlodipine group, compared with the atenolol group, and diastolic blood pressure averaged 1.6 mm Hg lower with amlodipine. (thefreelibrary.com)
  • Amlodipine is a medicine responsible for treating various forms of blood pressure ailments. (dokteronline.com)
  • Secondly, the article states: "Amlodipine also has been associated with worse cardiovascular outcome than [angiotensin-converting enzyme] ACE inhibitors despite similar effects on blood-pressure lowering. (aafp.org)
Perindopril2
Blooms the Chemist Amlodipine (amlodipine besylate) Drug / Medicine Information
Blooms the Chemist Amlodipine (amlodipine besylate) Drug / Medicine Information (news-medical.net)
Amlodipine and Benazepril | Lifescript.com
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DailyMed - TWYNSTA- telmisartan/amlodipine tablet, multilayer
DailyMed - TWYNSTA- telmisartan/amlodipine tablet, multilayer (dailymed.nlm.nih.gov)
Amlodipine Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Amlodipine Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD (webmd.com)
Amlodipine: Pediatric Medication | Memorial Sloan Kettering Cancer Center
Amlodipine: Pediatric Medication | Memorial Sloan Kettering Cancer Center (mskcc.org)
AMLOPRES 10 MG | Amlodipine Besylate
AMLOPRES 10 MG | Amlodipine Besylate (genericday.com)
Pritor/Amlodipine (telmisartan/amlodipine besilate) Drug / Medicine Information
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ALP 2 1/2 832 Pill Images (White / Round) (drugs.com)
Methyl Methacrylate Powder, Methyl Methacrylate Powder Suppliers and Manufacturers at Alibaba.com
Methyl Methacrylate Powder, Methyl Methacrylate Powder Suppliers and Manufacturers at Alibaba.com (alibaba.com)
Amlodipine: Uses, dosages, side effects, and interactions
Amlodipine: Uses, dosages, side effects, and interactions (medicalnewstoday.com)
Exforge (amlodipine, valsartan)
Exforge (amlodipine, valsartan) (netdoctor.co.uk)
93 7371 93 7371 Pill Images (Orange & White / Capsule-shape)
93 7371 93 7371 Pill Images (Orange & White / Capsule-shape) (drugs.com)
Caduet New FDA Drug Approval | CenterWatch
Caduet New FDA Drug Approval | CenterWatch (centerwatch.com)
Sevikar (amlodipine, olmesartan)
Sevikar (amlodipine, olmesartan) (netdoctor.co.uk)
MX43 Pill Images (Orange / Capsule-shape)
MX43 Pill Images (Orange / Capsule-shape) (drugs.com)
Exforge (amlodipine, valsartan)
Exforge (amlodipine, valsartan) (netdoctor.co.uk)
Ind-Swift Limited Product Information | Medindia
Ind-Swift Limited Product Information | Medindia (medindia.net)
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NORVASC 5 Pill Images (White / Eight-sided) (drugs.com)
These highlights do not include all the information needed to use VIAGRA safely and effectively. See full prescribing...
These highlights do not include all the information needed to use VIAGRA safely and effectively. See full prescribing... (dailymed.nlm.nih.gov)
Tribenzor New FDA Drug Approval | CenterWatch
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AB 4 Pill Images (White / Capsule-shape)
AB 4 Pill Images (White / Capsule-shape) (drugs.com)
Amlodipine And Olmesartan (Oral Route) Description and Brand Names - Mayo Clinic
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Sevikar HCT (amlodipine, olmesartan, hydrochlorothiazide)
Sevikar HCT (amlodipine, olmesartan, hydrochlorothiazide) (netdoctor.co.uk)
Perindopril And Amlodipine (Oral Route) Description and Brand Names - Mayo Clinic
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Grapefruit & Metformin | Livestrong.com
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Can Vitamin B-12 Deficiency Cause Hypoglycemia? | Livestrong.com
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