Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
Compounds with two BENZENE rings fused to AZEPINES.
A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.

The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. (1/363)

We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain. OT-7100 did not inhibit prostaglandin E2 biosynthesis at 10(-8)-10(-4) M. Single oral doses of 3 and 10 mg/kg OT-7100 were effective on the hyperalgesia induced by yeast. Single oral doses of 0.1, 0.3, 1 and 3 mg/kg OT-7100 were effective on the hyperalgesia induced by substance P in which indomethacin had no effect. Repeated oral administration of OT-7100 (10 and 30 mg/kg) was effective in normalizing the mechanical nociceptive threshold in the injured paw without affecting the nociceptive threshold in the uninjured paw in the Bennett model. Indomethacin had no effect in this model. While amitriptyline (10 and 30 mg/kg) and clonazepam (3 and 10 mg/kg) significantly normalized the nociceptive threshold in the injured paw, they also increased the nociceptive threshold in the uninjured paw. These results suggest that OT-7100 is a new type of analgesic with the effect of normalizing the nociceptive threshold in peripheral neuropathic hyperalgesia.  (+info)

Amitriptyline and procainamide inhibition of cocaine and cocaethylene degradation in human serum in vitro. (2/363)

Amitriptyline (AMI) and procainamide (PA) have been reported to inhibit the activity of human plasma butyrylcholinesterase, an enzyme important in the metabolic degradation of cocaine (COC) and its ethyl analogue cocaethylene (CE). Because both AMI and PA may be used in the treatment of COC intoxication and abuse, the effect of high pharmacological concentrations of these compounds on the degradation of COC and CE in pooled human serum was studied. AMI (1.8 micromol/L) modestly inhibited the degradation of COC by 4.2% and of CE by 4.0%. PA (42.5 micromol/L) profoundly inhibited degradation of COC by 42.7% and of CE by 47.2%. In contrast, lithium carbonate (1 mmol/L, control) showed no inhibition of degradation of either COC or CE. These results suggest that AMI and PA may prolong the half-life of COC and CE in human serum.  (+info)

Determination of amitriptyline and nortriptyline in human liver microsomes with reversed-phase HPLC in vitro. (3/363)

AIM: To develop a method for simultaneous determinations of amitriptyline (Ami) and its metabolite nortriptyline (Nor) in human liver microsomes. METHODS: An incubation buffer containing microsomes, NADPH-generating system, and Ami, after termination of enzyme reaction and desipramine (Des) as internal standard (IS), was extracted with diethy ether and separated on a reversed-phase ODS column. Detection was achieved at 242 nm by ultraviolet detector. RESULTS: No potential interfering peaks were found. Ami and Nor gave rapid elution and baseline resolution. The linear curves of both analyses ranged 0.02-10 nmol and the limit of detection was 0.01 nmol. The recovery (94%-101%) had good precision with relative s of < 8.3%. CONCLUSION: This method is rapid, sensitive, and simple for studying the metabolism of Ami and Nor.  (+info)

Pharmacokinetic and pharmacodynamic characterization of OROS and immediate-release amitriptyline. (4/363)

AIMS: To characterize the pharmacokinetics of amitriptyline and its metabolite nortriptyline following OROS and IR treatments, and to correlate them with anticholinergic side-effects. METHODS: The pharmacokinetics and safety of amitriptyline following administration of an osmotic controlled release tablet (OROS and an immediate release (IR) tablet were evaluated in 14 healthy subjects. In this randomized, open label, three-way crossover feasibility study, the subjects received a single 75 mg OROS tablet, three 25 mg IR tablets administered every 8 h, or 3x25 mg IR tablets administered at nighttime. In each treatment arm serial blood samples were collected for a period of 84 h after dosing. The plasma samples were analysed by gas chromatography for amitriptyline and its metabolite nortriptyline. Anticholinergic effects such as saliva output, visual acuity, and subject-rated drowsiness and dry mouth were measured on a continuous scale during each treatment period. RESULTS: Following dosing with OROS (amitriptyline hydrochloride), the mean maximal plasma amitriptyline concentration Cmax (15.3 ng ml-1 ) was lower and the mean tmax (25.7 h) was longer than that associated with the equivalent IR dose administered at nighttime (26.8 ng ml-1 and 6.3 h, respectively). The bioavailability of amitriptyline following OROS dosing was 95% relative to IR every 8 h dosing, and 89% relative to IR nighttime dosing. The metabolite-to-drug ratios after the three treatment periods were similar, suggesting no change in metabolism between treatments. The relationships between plasma amitriptyline concentration and anticholinergic effects (e.g. reduced saliva weight, dry mouth, and drowsiness) were similar with all three treatments. Of the anticholinergic effects, only decreased saliva weight and dry mouth correlated well with plasma amitriptyline concentrations; drowsiness did not. There was no apparent correlation between anticholinergic effects and the plasma nortriptyline concentration. CONCLUSIONS: The bioavailability of OROS (amitriptyline hydrochloride) was similar to that of the IR treatments and the pharmacokinetics of amitriptyline after OROS dosing may decrease the incidence of anticholinergic effects compared with that seen with nighttime dosing of the IR formulation. Therefore, this controlled-release formulation of amitriptyline may be appropriate for single daily administration.  (+info)

Relaxant effects of antidepressants on human isolated mesenteric arteries. (5/363)

AIMS: The therapeutic action of tricyclic agents may be accompanied by unwanted effects on the cardiovascular system. The evidence for the effects on vascular and nonvascular smooth muscle comes from animal studies. Whether these studies can be extrapolated to human vessels remains to be determined. Therefore, the present study was designed to investigate the influence of amitriptyline, nortriptyline and sertraline on the contractile responses of human isolated mesenteric arteries to electrical field stimulation, noradrenaline and potassium chloride. METHODS: Arterial segments (lumen diameter 0.8-1.2 mm) were obtained from portions of the human omentum during the course of 41 abdominal operations (22 men and 19 women), and rings 3 mm long were mounted in organ baths for isometric recording of tension. In some artery rings the endothelium was removed mechanically. RESULTS: In precontracted artery rings amitriptyline, nortriptyline and sertraline (3x10(-7)-10(-4) m ) produced concentration-dependent relaxation that was independent of the presence or absence of vascular endothelium. Incubation with indomethacin (3x10(-6) m ) reduced the pD2 values thus indicating the participation of dilating prostanoid substances in this response. Amitriptyline and nortriptyline inhibited both the neurogenic-and noradrenaline-induced contractions. In contrast, only the highest concentration of sertraline reduced the adrenergic responses. Amitriptyline, nortriptyline and sertraline inhibited contractions elicited by KCl and produced rightward shifts of the concentration-response curve to CaCl2 following incubation in calcium-free solution. CONCLUSIONS: These results indicate that amitriptyline and nortriptyline could act as adrenoceptor antagonists and direct inhibitors of smooth muscle contraction of human mesenteric arteries, whereas sertraline might principally exert its action only as direct inhibitor of smooth muscle contraction. This relaxant mechanism involves an interference with the entry of calcium.  (+info)

Inhibition of the high affinity myo-inositol transport system: a common mechanism of action of antibipolar drugs? (6/363)

The mechanism of action of antibipolar drugs like lithium, carbamazepine, and valproate that are used in the treatment of manic-depressive illness, is unknown. Lithium is believed to act through uncompetitive inhibition of inositolmonophosphatase, which results in a depletion of neural cells of inositol and a concomitant modulation of phosphoinositol signaling. Here, we show that lithium ions, carbamazepine, and valproate, but not the tricyclic antidepressant amitriptyline, inhibit at therapeutically relevant concentrations and with a time course similar to their clinical actions the high affinity myo-inositol transport in astrocyte-like cells and downregulate the level of the respective mRNA. Inhibition of inositol uptake could thus represent an additional pathway for inositol depletion, which might be relevant in the mechanism of action of all three antibipolar drugs.  (+info)

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline. (7/363)

1 Tricyclic antidepressants (TCAs) are associated with cardiovascular side effects including prolongation of the QT interval of the ECG. In this report we studied the effects of two TCAs (imipramine and amitriptyline) on ionic current mediated by cloned HERG potassium channels. 2 Voltage clamp measurements of HERG currents were made from CHO cells transiently transfected with HERG cDNA. HERG-encoded potassium channels were inhibited in a reversible manner by both imipramine and amitriptyline. HERG tail currents (IHERG) following test pulses to +20 mV were inhibited by imipramine with an IC50 of 3.4+/-0.4 microM (mean+/-s.e.mean) and a Hill coefficient of 1.17+/-0.03 (n = 5). 3 microM amitriptyline inhibited IHERG by 34+/-6% (n = 3). The inhibition showed only weak voltage dependence. 3 Using an 'envelope of tails' comprised of pulses to +20 mV of varying durations, the tau of activation was found to be 155+/-30 ms for control and 132+/-26 ms for 3 microM imipramine (n = 5). Once maximal channel activation was achieved after 320 ms (as demonstrated by maximal tail currents), further prolongation of depolarization did not increase imipramine-mediated HERG channel inhibition. 4 Taking current measurements every second during a 10 s depolarizing pulse from -80 mV to 0 mV, block was observed during the first pulse in the presence of imipramine and the level of IHERG block was similar throughout the pulse (n=5). 5 A three pulse protocol (two depolarizing pulses to +20 mV separated by 20 ms at -80 mV) revealed that imipramine did not significantly alter the kinetics of IHERG inactivation. The tau of inactivation was 8+/-2 ms and 5.6+/-0.4 ms (n = 5) in the absence and presence of 3 microM imipramine, respectively, and currents inactivated to a similar extent. 6 Our data are consistent with TCAs causing components of block of the HERG channel in both the closed and open states. Any component of open channel block occurs rapidly upon depolarization. Inhibition of IHERG by the prototype TCAs imipramine and amitriptyline may suggest a mechanism for QT prolongation associated with risks of arrhythmia and sudden death that accompany high concentrations of TCAs following overdose.  (+info)

Fluoxetine and amitriptyline inhibit nitric oxide, prostaglandin E2, and hyaluronic acid production in human synovial cells and synovial tissue cultures. (8/363)

OBJECTIVE: To evaluate the effects of fluoxetine and amitriptyline on nitric oxide (NO), prostaglandin E2 (PGE2), and hyaluronic acid (HA) production in human synovial cells and synovial tissue cultures. METHODS: Human synovial cells, synovial tissue, and cartilage were cultured in the presence or absence of cytokines, lipopolysaccharides (LPS), fluoxetine, or amitriptyline. Production of NO, PGE2, and HA was determined in culture media. Sulfated glycosaminoglycan (S-GAG) synthesis was evaluated in cartilage by 35S incorporation. RESULTS: Fluoxetine (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) inhibited NO release by 56%, 62%, and 71%, respectively, in the media of synovial cells stimulated by interleukin-1alpha (IL-1alpha; 1 ng/ml) plus tumor necrosis factor alpha (TNFalpha; 30 ng/ml). Amitriptyline (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) caused a 16%, 27.3%, and 51.4% inhibition of NO release. Fluoxetine and amitriptyline (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) significantly (P<0.05) inhibited PGE2 release in the media of human synovial cells in the presence of IL-1alpha plus TNFalpha, in a dose-dependent manner (up to 88% inhibition). Fluoxetine (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) and amitriptyline (1 microg/ml and 3 microg/ml) significantly (P<0.05) inhibited PGE2 release in the media of human synovial tissue in the presence of LPS. Fluoxetine and amitriptyline (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) also significantly (P<0.05) inhibited HA production by human synovial cells in the presence of IL-1beta plus TNFalpha. Fluoxetine and amitriptyline (1 microg/ml) partially reversed IL-1beta-induced inhibition of 35S-GAG synthesis by human cartilage cultures (P<0.05). Neither fluoxetine nor amitriptyline had a toxic effect on cells in the concentrations used. CONCLUSION: Inhibition of NO and PGE2 production by connective tissue cells is a mechanism by which some antidepressant medications may affect pain, articular inflammation, and joint damage.  (+info)

Therapeutic levels of amitriptyline range from 75 to 175 ng/mL (270-631 nM), or 80-250 ng/mL of both amitriptyline and its ... Amitriptyline, as the most commonly used of them, is recommended as a first-line agent for its therapy. Amitriptyline may ... Amitriptyline is the English and French generic name of the drug and its INN, BAN, and DCF, while amitriptyline hydrochloride ... Amitriptyline is probably effective for the prevention of periodic migraine in adults. Amitriptyline is similar in efficacy to ...
Bryson, HM; Wilde, MI (1 June 1996). "Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic ... pregabalin Antidepressants amitriptyline, duloxetine, venlafaxine Antihistamines hydroxyzine, promethazine Stimulants caffeine ...
"Amitriptyline". MedlinePlus. 19 March 2020. Retrieved 28 March 2020. Moulin DE, Foley KM, Ebers GC (December 1988). "Pain ... Both Lhermitte's sign and painful dysesthesias usually respond to treatment with carbamazepine, clonazepam, or amitriptyline. ...
Leucht C, Huhn M, Leucht S (December 2012). Leucht C (ed.). "Amitriptyline versus placebo for major depressive disorder". The ... Guaiana G, Barbui C, Hotopf M (July 2007). "Amitriptyline for depression". The Cochrane Database of Systematic Reviews. 18 (3 ... Similarly, a Cochrane systematic review of clinical trials of the generic tricyclic antidepressant amitriptyline concluded that ...
B. denied suicidal ideation or intent but did admit to taking over 800 mg of amitriptyline per day for the past 3 years after ... She clearly described a euphoria associated with amitriptyline, noting that it gave her a "buzz" and that she felt "numbed up" ... Several cases of the misuse of amitriptyline alone or together with methadone or in other drug dependent patients and of ... Merck introduced the second member of the TCA family, amitriptyline (Elavil), in 1961. This compound has a different three-ring ...
ISBN 3-88763-075-0. Rapp W (September 1978). "Comparative trial of amitriptyline-N-oxide and amitriptyline in the treatment of ... Godt HH, Fredslund-Andersen K, Edlund AH (1971). "[Amitriptyline N-oxide. A new antidepressant. A clinical double-blind trial ... Amitriptylinoxide is both an analogue and metabolite of amitriptyline, and has similar effects as well as equivalent efficacy ... Maj J, Vetulani J, Michaluk J, Rogóz Z, Skuza G (November 1982). "Central action of amitriptyline N-oxide". Pharmacopsychiatria ...
"amitriptyline (Rx) - Elavil, Levate". Medscape Drugs & Diseases. Guardiola, A; Terra, AR; Ferreira, LT; Londero, RG (September ... 1999). "[Use of amitriptyline in attention deficit hyperactivity disorder]". Arq Neuropsiquiatr (in Portuguese). 57 (3A): 599- ...
Amitriptyline has been more frequently studied of the antidepressants and is the only antidepressant with fairly consistent ... The main two side effects that occur from taking amitriptyline are drowsiness and a dry mouth. Other common side effects of ... "Amitriptyline: Side Effects, Dosage, Uses". Archived from the original on 2013-01-03. Klapper J (1997). " ... using amitriptyline are mostly due to its anticholinergic activity, including: weight gain, changes in appetite, muscle ...
In addition, while amitriptyline has been used as a first line treatment, the quality of evidence to support this use and ... Any potential benefits from the antidepressant amitriptyline may take up to three months to take effect and it may take between ... Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ (July 2015). "Amitriptyline for neuropathic pain in adults". The Cochrane ... As of 2018, the only tricyclic antidepressant (TCA) that has sufficient evidence is amitriptyline. For most people with ...
A 2015 Cochrane systematic review of amitriptyline found that there was no evidence supporting the use of amitriptyline that ... The authors believe amitriptyline may have an effect in some patients but that the effect is overestimated. A 2014 Cochrane ... The NHS for example explicitly state that amitriptyline and gabapentin can be used for treating the pain of sciatica. This is ... Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ (July 2015). "Amitriptyline for neuropathic pain in adults". The Cochrane ...
Zhang, D.; Evans, F. E.; Freeman, J. P.; Duhart Jr, B.; Cerniglia, C. E. (1995). "Biotransformation of amitriptyline by ... Cunninghamella elegans is able to transform the tricyclic antidepressants amitriptyline and doxepin, the tetracyclic ...
A double-blind study vs amitriptyline". Headache. 30 (7): 439-44. doi:10.1111/j.1526-4610.1990.hed3007439.x. hdl:11380/740716. ...
Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ (July 2015). "Amitriptyline for neuropathic pain in adults". The Cochrane ... The same group reviewed data for amitriptyline in the treatment of neuropathic pain and found limited useful randomized ... The group was concerned about the potential for overestimating the amount of pain relief provided by amitriptyline, and ... Antidepressants including amitriptyline, fluoxetine, duloxetine, milnacipran, moclobemide, and pirlindole are recommended by ...
Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ (July 2015). "Amitriptyline for neuropathic pain in adults". The Cochrane ...
It contains Amitriptyline hydrochloride and Perphenazine. It is sold in the following forms: Minitran 2-10: 2 mg Perphenazine ... Minitran 2-25: 2 mg Perphenazine and 25 mg Amitriptyline hydrochloride in each tablet. Minitran 4-10: 4 mg Perphenazine and 10 ... Minitran 4-25: 4 mg Perphenazine and 25 mg Amitriptyline hydrochloride in each tablet. Minitran is also a pharmaceutical drug ... and 10 mg Amitriptyline hydrochloride in each tablet. ...
Tricyclic antidepressants, e.g. amitriptyline, clomipramine. Additive effect. Adrenergic decongestants, e.g. phenylephrine. ...
These include amitriptyline, nortriptyline, and doxepin. Acute treatments (short-term treatment) include drugs called ...
Among the TCAs, amitriptyline is most widely used for this condition, but desipramine and nortriptyline have fewer side effects ... TCAs include imipramine, amitriptyline, desipramine, and nortriptyline. They are generally regarded as first or second-line ... and amitriptyline were more effective than placebo, but that comparative effectiveness between each agent is unclear. The only ...
Of the TCAs, noxiptiline has been described as one of the most effective, rivaling amitriptyline in clinical efficacy. Ths ... multicentre comparison with amitriptyline". Pharmakopsychiatrie, Neuro-Psychopharmakologie. 8 (1): 26-35. doi:10.1055/s-0028- ...
... is an analogue of amitriptyline with an isobutyl side chain instead of a propylidene side chain. It is a tertiary ... Butriptyline is closely related to amitriptyline, and produces similar effects as other TCAs, but its side effects like ... However, in small clinical trials, using similar doses, butriptyline was found to be similarly effective to amitriptyline and ... Other tertiary amine TCAs include amitriptyline, imipramine, clomipramine, dosulepin (dothiepin), doxepin, and trimipramine. ...
... notably greater affinity relative to amitriptyline and imipramine). It is known to produce two active metabolites during first- ...
Gabapentin or amitriptyline may be used to treat some of the symptoms. In 2017, the United States Centers for Disease Control ( ... Some medications such as amitriptyline may reduce some symptoms, such as fatigue and paresthesia, although benefit does not ... ISBN 978-3-540-94069-2. Davis R, Villar L (1986). "Symptomatic improvement with amitriptyline in ciguatera fish poisoning". N. ...
Examples include imipramine, doxepin, amitriptyline, nortriptyline and desipramine. TCAs may cause drug poisoning in patients ...
Traditionally, antidepressants such as sertraline, fluoxetine, citalopram, nortriptyline and amitriptyline have been prescribed ... "Treatment of Pathologic Laughing and Weeping with Amitriptyline". The New England Journal of Medicine. 312 (23): 1480-2. doi: ...
She had committed suicide by overdosing on amitriptyline. She died a week after the death of her sister, Nombuso Masango, whose ...
ROSE JT, LEAHY MR, PLOWMAN R (October 1963). "A comparison of phenoxypropazine and amitriptyline in depression". The American ...
... is a secondary amine TCA, with its N-methylated relative amitriptyline being a tertiary amine. Other secondary ... Other dibenzocycloheptadiene TCAs include amitriptyline, nortriptyline, and butriptyline. ...
Medications may include ibuprofen, pentosan polysulfate, or amitriptyline. Procedures may include bladder distention, nerve ... clinical trial.Amitriptyline has been shown to be effective in reducing symptoms such as chronic pelvic pain and nocturia in ... amitriptyline, cimetidine or hydroxyzine, pentosan polysulfate), bladder instillations (DMSO, heparin, or lidocaine) Third-line ...
Other options include lamotrigine, baclofen, gabapentin, amitriptyline and pimozide. Opioids are not usually effective in the ... Antidepressant medications, such as amitriptyline have shown good efficacy in treating trigeminal neuralgia, especially if ... September 2012). "Management of Trigeminal Neuralgia using Amitriptyline and Pregablin combination Therapy". African Journal of ...
"Levate (amitriptyline), dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 1 ... Examples include: Serotonin antagonists and reuptake inhibitors Trazodone Tricyclic antidepressants Amitriptyline Doxepin ...
Amitriptyline: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Amitriptyline comes as a tablet to take by mouth. It is usually taken one to four times a day. Take amitriptyline at around the ... Continue to take amitriptyline even if you feel well. Do not stop taking amitriptyline without talking to your doctor. If you ... Before taking amitriptyline,. *tell your doctor and pharmacist if you are allergic to amitriptyline or any other medications. ...
Does amitriptyline alter stress-induced hypersensitivity in patients with irritable bowel syndrome? ... Aim: To assess whether treatment with a drug effective in treating IBS (amitriptyline) alters the response to acute stress in ... Cite this: Amitriptyline Modifies the Visceral Hypersensitivity Response to Acute Stress in the Irritable Bowel Syndrome - ... Amitriptyline Modifies the Visceral Hypersensitivity Response to Acute Stress in the Irritable Bowel Syndrome. Visceral ...
Amitriptyline is excreted into breast milk. In one report in which a patient received amitriptyline 100 mg/day while nursing ... Amitriptyline hydrochloride is an antidepressant with sedative effects. Its mechanism of action in man is not known. It is not ... Amitriptyline has been shown to cross the placenta. Although a causal relationship has not been established, there have been a ... Amitriptyline is metabolized by N-demethylation and bridge hydroxylation in man, rabbit, and rat. Virtually the entire dose is ...
Amitriptyline Amitriptyline is used to treat symptoms of depression. Amitriptyline is in a class of medications called ... Amitriptyline and perphenazine overdose Amitriptyline and perphenazine is a combination drug. It is sometimes prescribed for ... Amitriptyline hydrochloride overdose Amitriptyline hydrochloride is a type of prescription medicine called a tricyclic ... mL (25.62 to 42.70 micromol/L) Amitriptyline: 120 to 150 ng/mL (432.60 to ... than 25 mcg/mL (42.70 micromol/L) Amitriptyline: ...
Amitriptyline can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic ... Amitriptyline is a tricyclic antidepressant that is widely used in the therapy of depression. ... Amitriptyline is a tricyclic antidepressant that is widely used in the therapy of depression. Amitriptyline can cause mild and ... Amitriptyline is also used for anorexia and bulimia and for adjunctive treatment of neurogenic pain. Amitriptyline is available ...
The authors report the case of a patient who received amitriptyline on 2 occasions. On both occasions, she had fever and ... Amitriptyline-induced fulminant hepatitis G Danan, J Bernuau, X Moullot, C Degott, D Pessayre ... Hepatitis caused by amitriptyline therapy. Yon J, Anuras S. Yon J, et al. JAMA. 1975 May 26;232(8):833-4. JAMA. 1975. PMID: ... Intrahepatic obstructive jaundice from amitriptyline. Biagi RW, Bapat BN. Biagi RW, et al. Br J Psychiatry. 1967 Oct;113(503): ...
... (a-mee-TRIP-ti-leen) Antidepressant Medicines, Depression and other Serious Mental ...
Youve probably seen this warning on medicines youve taken. The danger is real. Mixing alcohol with certain medications can cause nausea and vomiting, headaches, drowsiness, fainting, or loss of coordination. It also can put you at risk for internal bleeding, heart problems, and difficulties in breathing. In addition to these dangers, alcohol can make a medication less effective or even useless, or it may make the medication harmful or toxic to your body.
amitriptyline. Pamelor. nortriptyline. Sinequan. doxepin. Tofranil. imipramine. Side effects. Tricyclic antidepressants can ...
Amitriptyline. Nortriptyline. These tricyclic antidepressants can be used to treat pain.. Neurotoxins. Botulinum toxin Type A ...
Amitriptyline treatment also caused a significant potentiation of non-toxic Aβ monomer with a concomitant decrease in cytotoxic ... In addition, amitriptyline administration caused a significant increase in dentate gyrus neurogenesis as well as increases in ... In this study, amitriptyline, an FDA-approved tricyclic antidepressant, was administered orally to aged and cognitively ... Amitriptyline treatment resulted in increases in hippocampal brain-derived neurotrophic factor protein as well as increased ...
Amitriptyline. CYP2D6. Lithium. Renal. Ampicillin. Renal. Meperidine. Esterase. Antipyrine. CYP: mixed/unknown. Mephobarbital-r ...
Amitriptyline is an antidepressant; d-propoxyphene is a narcotic analgesic; secobarbitol is a barbiturate sedative. Data in ... Amitriptyline d-Propoxyphene Secobarbital Year combination (Elavil) (Darvon) (Seconal ...
Likely serotoninergic syndrome from an interaction between amitryptiline, paroxetine, and linezolid] [in Spanish]. Farm Hosp. ... or amitriptyline (28,29). Hence, when long-term use of linezolid is unavoidable because of highly resistant TB, drugs that ... amitriptyline, mianserin, or oxazepam. Peripheral neuropathy worsened, causing severe leg pain requiring analgesia (opioids, ...
We actually had to, we tried him up on Amitriptyline briefly. He didnt like it. We went back to Nortriptyline. We also gave ...
We actually had to, we tried him up on Amitriptyline briefly. He didnt like it. We went back to Nortriptyline. We also gave ...
In a similar study (Rothe et al.), hair samples from 15 patients receiving medical treatment with amitriptyline, carbamazepine ...
Amitriptyline hydrochloride (substance). Code System Preferred Concept Name. Amitriptyline hydrochloride (substance). Concept ...
They include trazodone, amitriptyline, and nortriptyline. Cyclobenzaprine, a muscle relaxant, can also help people sleep to ...
CPIC Dosing Guideline for amitriptyline and CYP2C19, CYP2D6 The CPIC Dosing Guideline for amitriptyline recommends an ... amitriptyline, and clomipramine. Metabolic phenotypes of CYP2C19 were not robustly associated with the investigated treatment ... and the tricyclic antidepressants amitriptyline and clomipramine (HR?=?1.46, 95% CI?=?1.05-2.02, p?=?0.024). ...
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  • Amitriptyline is metabolized to nortriptyline which has antidepressant activity equal to amitriptyline's. (
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  • Amitriptyline belongs to the class of drugs known as tricyclic antidepressants. (
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  • Amitriptyline and chlordiazepoxide is a combination medicine used to treat moderate to severe depression and anxiety. (
  • APO-AMITRIPTYLINE (Amitriptyline hydrochloride) is indicated in the treatment and management of depressive illness of psychotic or endogenous nature and in selected patients with neurotic depression, and is also of value in alleviating the anxiety component of depression. (
  • Amitriptyline, or 3-(10,11-dihydro-5H-dibenzo [a,d] cycloheptene-5-ylidene)-N,N-dimethyl-1-propanamine, was first approved by the U.S. Food and Drug Administration for the treatment of depression. (
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  • One of the reasons why amitriptyline is considered a game-changer is because it has been proven to be effective in treating depression, even in cases where other antidepressants have failed. (
  • Overall, amitriptyline is a powerful tool in the fight against depression that should not be overlooked. (
  • By increasing the levels of these neurotransmitters, amitriptyline helps to regulate mood and alleviate depression symptoms. (
  • Amitriptyline is also effective in treating depression because it blocks the reuptake of neurotransmitters, such as serotonin and norepinephrine. (
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  • Amitriptyline can interact with other drugs, increasing your risk for side effects. (
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  • Unlike other antidepressants, amitriptyline impacts both serotonin and norepinephrine receptors that help to regulate the mood and reduce feelings of sadness, anxiety, and hopelessness. (
  • Amitriptyline not only helps to improve mood and alleviate depressive symptoms but it also helps to reduce anxiety levels, increase the quality of sleep and improve the overall quality of life. (
  • What is the usual dose of amitriptyline for migraine? (
  • The recommended starting dose of amitriptyline for migraine is 10 milligrams (mg) per day. (
  • The maximum dose of amitriptyline is 300 mg per day, and higher doses are more likely to cause side effects. (
  • Milk amitriptyline levels were highest at 1.5 and 6 hours after the dose at 103 and 100 mcg/L, respectively. (
  • Two mothers who were taking amitriptyline had milk samples taken 12 to 15 hours after their daily dose. (
  • Typically, the starting dose of Amitriptyline is low and gradually increased over time as the patient tolerates the medication. (
  • To generate evidence in support of this probability, a single 100 mg dose of Amitriptyline an object drug was administered with 10 mg of Amlodipine as a precipitating drug in an open label, randomized parallel group, controlled clinical study based on PK/PD analysis model. (
  • 500 to 600 mL daily) during maternal use of amitriptyline 175 mg daily, amitriptyline and its metabolites were undetectable in the serum of one infant. (
  • Animal studies with the combination amitriptyline-chlordiazepoxide have not been reported. (
  • Amitriptyline-Chlordiazepoxide (amitriptyline-chlordiazepoxide). (
  • Amitriptyline and chlordiazepoxide may also be used for purposes not listed in this medication guide. (
  • What is Amitriptyline And Chlordiazepoxide (Limbitrol) used for? (
  • Do not use amitriptyline and chlordiazepoxide if you have used an MAO inhibitor in the past 14 days. (
  • Amitriptyline and chlordiazepoxide may harm an unborn baby. (
  • If you use amitriptyline and chlordiazepoxide while you are pregnant, your baby could become dependent on the drug. (
  • Amitriptyline hydrochloride overdose occurs when someone takes more than the normal or recommended amount of this medicine. (
  • Below are symptoms of an amitriptyline hydrochloride overdose in different parts of the body. (
  • An amitriptyline hydrochloride overdose can be very serious. (
  • This interference with reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline. (
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  • Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. (
  • Amitriptyline increases the effects of the neurotransmitter serotonin in the brain. (
  • The risk or severity of serotonin syndrome can be increased when Amitriptyline is combined with Tramadol. (
  • As a tricyclic antidepressant, amitriptyline works by increasing the levels of chemical messengers, such as serotonin and norepinephrine in the brain. (
  • By addressing various depressive symptoms, amitriptyline can help individuals regain control of their mood, sleep, appetite, and overall sense of well-being. (
  • Amitriptyline works by increasing the levels of specific chemicals in the brain that help to balance the mood and alleviate depressive symptoms. (
  • Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline . (
  • Read the Medication Guide provided by your pharmacist before you start taking amitriptyline and each time you get a refill. (
  • Amitriptyline is considered a drug whose effect on the nursing infant is unknown but may be of concern by the American Academy of Pediatrics. (
  • RESUME Afin d'examiner l'expérience d'une clinique de pédopsychiatrie en ce qui concerne la comorbidité et les caractéristiques du traitement des enfants souffrant d'hyperactivité avec déficit de l'attention (HADA), une étude rétrospective a été réalisée auprès des patients de moins de 19 ans qui consultaient à la clinique et chez lesquels un diagnostic de HADA avait été posé. (
  • Amitriptyline is sometimes prescribed off-label at low doses to prevent migraine attacks. (
  • Fifteen male Wistar rats were given systemic injections of duloxetine , amitriptyline or saline prior to a Forced Swimming Test (FST). (
  • In addition to its effectiveness, amitriptyline is also attractive to many because it is relatively inexpensive compared to other antidepressants, making it a more accessible option for patients who may not have the financial resources for other treatments. (
  • However, the review also reported that children between 10 and 17 who were treated with amitriptyline alongside cognitive behavioral therapy (CBT) were more likely to experience a reduction in chronic headaches. (
  • After amitriptyline treatment, cognitive behavior testing demonstrated that there was a significant improvement in both long- and short-term memory retention. (
  • In this study, amitriptyline, an FDA-approved tricyclic antidepressant, was administered orally to aged and cognitively impaired transgenic AD mice (3×TgAD). (
  • Amlodipine 10 mg was administered which lowered the DBP by nearly 5 to 10 mm Hg, when the Amitriptyline was administered orally and the plasma samples were drawn for PK analysis along with PD parameters in a designed time event profile. (
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  • However, both sublingual and oral formulations can have issues with the stability of the APIs and the physical compositions themselves, especially when a basifying agent (a chemical compound that increases the pH of solutions after dissolution of Cyclobenzaprine HCl or Amitriptyline HCl) is present. (
  • Therefore, a method or composition that increases stability of Cyclobenzaprine HCl or Amitriptyline HCl (with or without the presence of a basifying agent) in a formulation would be useful. (
  • In addition, amitriptyline administration caused a significant increase in dentate gyrus neurogenesis as well as increases in expression of neurosynaptic marker proteins. (
  • Amitriptyline treatment resulted in increases in hippocampal brain-derived neurotrophic factor protein as well as increased tyrosine phosphorylation of its cognate receptor (TrkB). (
  • Amitriptyline hydrochloride is contraindicated in patients who have shown prior hypersensitivity to it. (
  • Amitriptyline hydrochloride is not approved for use in pediatric patients. (
  • Amitriptyline use during the first trimester has resulted in case reports of limb reduction anomalies and other malformations. (
  • However, Cyclobenzaprine HCl or Amitriptyline HCl have slow absorption when ingested by mouth (per oral, or po). (
  • What are the side effects of taking amitriptyline for migraine? (
  • Like any medication, amitriptyline can cause side effects . (

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