Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.Thyrotoxicosis: A hypermetabolic syndrome caused by excess THYROID HORMONES which may come from endogenous or exogenous sources. The endogenous source of hormone may be thyroid HYPERPLASIA; THYROID NEOPLASMS; or hormone-producing extrathyroidal tissue. Thyrotoxicosis is characterized by NERVOUSNESS; TACHYCARDIA; FATIGUE; WEIGHT LOSS; heat intolerance; and excessive SWEATING.Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Electric Countershock: An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Tachycardia, Paroxysmal: Abnormally rapid heartbeats with sudden onset and cessation.Tachycardia, Ectopic Junctional: A rare form of supraventricular tachycardia caused by automatic, not reentrant, conduction initiated from sites at the atrioventricular junction, but not the ATRIOVENTRICULAR NODE. It usually occurs during myocardial infarction, after heart surgery, or in digitalis intoxication with a HEART RATE ranging from 140 to 250 beats per minute.Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.Thyroid Function Tests: Blood tests used to evaluate the functioning of the thyroid gland.Heart: The hollow, muscular organ that maintains the circulation of the blood.Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Thyroid Diseases: Pathological processes involving the THYROID GLAND.Thyroid Hormones: Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.Citrus paradisi: A plant species of the genus CITRUS, family RUTACEAE that produces the familiar grapefruit. There is evidence that grapefruit inhibits CYTOCHROME P-450 CYP3A4, resulting in delayed metabolism and higher blood levels of a variety of drugs.Night Vision: Function of the human eye that is used in dim illumination (scotopic intensities) or at nighttime. Scotopic vision is performed by RETINAL ROD PHOTORECEPTORS with high sensitivity to light and peak absorption wavelength at 507 nm near the blue end of the spectrum.Food-Drug Interactions: The pharmacological result, either desirable or undesirable, of drugs interacting with components of the diet. (From Stedman, 25th ed)Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.Citrus: A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing.beta-Thalassemia: A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.Trimethoprim Resistance: Nonsusceptibility of bacteria to the action of TRIMETHOPRIM.Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Materia Medica: Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.Chronobiology Disorders: Disruptions of the rhythmic cycle of bodily functions or activities.Library Services: Services offered to the library user. They include reference and circulation.Libraries, MedicalAtrioventricular Block: Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Heart Conduction System: An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.Electric Stimulation: Use of electric potential or currents to elicit biological responses.Hepatitis, Infectious Canine: A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Antibiosis: A natural association between organisms that is detrimental to at least one of them. This often refers to the production of chemicals by one microorganism that is harmful to another.

Effects of cycloprotobuxine-A on atrial fibrillation. (1/719)

AIM: To study the effects of cycloprotobuxine-A (Cyc-A) on atrial fibrillation. METHODS: Atrial fibrillations in vivo and in vitro were induced by arrhythmogenic drugs. Action potentials were measured by the standard microelectrode technique. RESULTS: Cyc-A, similar to or slightly stronger than amiodarone (Ami), decreased incidences of atrial fibrillation elicited by CaCl2-acetylcholine in mice and increased doses of aconitine, ouabain, or adrenaline to elicit atrial fibrillation in isolated guinea pig atria. Cyc-A 0.3-100 mumol.L-1 decreased the normal automaticity and 0.3-30 mumol.L-1 attenuated or almost abolished the isoprenaline-induced abnormal increase in automaticity in sinus nodal cells. In isolated left atria, Cyc-A 0.3-30 mumol.L-1 inhibited the abnormal rhythmic activity elicited by adrenaline, prolonged action potential duration (APD) and effective refractory period, and reduced excitability. At 3-30 mumol.L-1, Cyc-A also decreased the maximal velocity of depolarization (Vmax). Cyc-A antagonized the acetylcholine-induced shortening of APD. These electrophysiologic effects were similar to those of amiodarone, but Ami did not affect the Vmax. CONCLUSION: Cyc-A produces a protective effect against experimental atrial fibrillation via a prolongation of repolarization, a decease of automaticity, and an inhibition of excitability.  (+info)

Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease. (2/719)

Many substrates for P-glycoprotein, an ABC transporter that mediates multidrug resistance in mammalian cells, have been shown to stimulate its ATPase activity in vitro. In the present study, we used this property as a criterion to search for natural and artificial substrates and/or allosteric regulators of ABCR, the rod photoreceptor-specific ABC transporter responsible for Stargardt disease, an early onset macular degeneration. ABCR was immunoaffinity purified to apparent homogeneity from bovine rod outer segments and reconstituted into liposomes. All-trans-retinal, a candidate ligand, stimulates the ATPase activity of ABCR 3-4-fold, with a half-maximal effect at 10-15 microM. 11-cis- and 13-cis-retinal show similar activity. All-trans-retinal stimulates the ATPase activity of ABCR with Michaelis-Menten behavior indicative of simple noncooperative binding that is associated with a rate-limiting enzyme-substrate intermediate in the pathway of ATP hydrolysis. Among 37 structurally diverse non-retinoid compounds, including nine previously characterized substrates or sensitizers of P-glycoprotein, only four show significant ATPase stimulation when tested at 20 microM. The dose-response curves of these four compounds are indicative of multiple binding sites and/or modes of interaction with ABCR. Two of these compounds, amiodarone and digitonin, can act synergistically with all-trans-retinal, implying that they interact with a site or sites on ABCR different from the one with which all-trans-retinal interacts. Unlike retinal, amiodarone appears to interact with both free and ATP-bound ABCR. Together with clinical observations on Stargardt disease and the localization of ABCR to rod outer segment disc membranes, these data suggest that retinoids, and most likely retinal, are the natural substrates for transport by ABCR in rod outer segments. These observations have significant implications for understanding the visual cycle and the pathogenesis of Stargardt disease and for the identification of compounds that could modify the natural history of Stargardt disease or other retinopathies associated with impaired ABCR function.  (+info)

Fetal tachycardias: management and outcome of 127 consecutive cases. (3/719)

OBJECTIVE: To review the management and outcome of fetal tachycardia, and to determine the problems encountered with various treatment protocols. STUDY DESIGN: Retrospective analysis. SUBJECTS: 127 consecutive fetuses with a tachycardia presenting between 1980 and 1996 to a single tertiary centre for fetal cardiology. The median gestational age at presentation was 32 weeks (range 18 to 42). RESULTS: 105 fetuses had a supraventricular tachycardia and 22 had atrial flutter. Overall, 52 fetuses were hydropic and 75 non-hydropic. Prenatal control of the tachycardia was achieved in 83% of treated non-hydropic fetuses compared with 66% of the treated hydropic fetuses. Digoxin monotherapy converted most (62%) of the treated non-hydropic fetuses, and 96% survived through the neonatal period. First line drug treatment for hydropic fetuses was more diverse, including digoxin (n = 5), digoxin plus verapamil (n = 14), and flecainide (n = 27). The response rates to these drugs were 20%, 57%, and 59%, respectively, confirming that digoxin monotherapy is a poor choice for the hydropic fetus. Response to flecainide was faster than to the other drugs. Direct fetal treatment was used in four fetuses, of whom two survived. Overall, 73% (n = 38) of the hydropic fetuses survived. Postnatally, 4% of the non-hydropic group had ECG evidence of pre-excitation, compared with 16% of the hydropic group; 57% of non-hydropic fetuses were treated with long term anti-arrhythmics compared with 79% of hydropic fetuses. CONCLUSIONS: Non-hydropic fetuses with tachycardias have a very good prognosis with transplacental treatment. Most arrhythmias associated with fetal hydrops can be controlled with transplacental treatment, but the mortality in this group is 27%. At present, there is no ideal treatment protocol for these fetuses and a large prospective multicentre trial is required to optimise treatment of both hydropic and non-hydropic fetuses.  (+info)

Electrophysiologic effects of chronic amiodarone therapy and hypothyroidism, alone and in combination, on guinea pig ventricular myocytes. (4/719)

Amiodarone is a widely used antiarrhythmic drug, the mechanisms of action of which remain incompletely understood. Indirect evidence suggests that the class III properties of amiodarone may be mediated by cardiac antithyroid effects. We sought to determine whether the effects of chronic amiodarone on repolarization in guinea pig hearts can be attributed to an antithyroid action by studying the changes in dofetilide-sensitive rapid (IKr) and dofetilide-resistant slow (IKs) delayed rectifier currents, inward rectifier K+ current (IK1), and action potentials of ventricular myocytes from five groups of guinea pigs: control, hypothyroid, amiodarone-treated for 7 days, hypothyroid plus amiodarone, and vehicle (dimethyl sulfoxide) treated. IKs was reduced by amiodarone (to 61% of control, P <.05, at 50 mV) but was more strongly reduced by hypothyroidism (to 35% of control, P <.01, 50 mV). Amiodarone significantly reduced IKr and IK1 (by 55 and 64% at 10 mV and -50 mV, respectively), which were unaffected by hypothyroidism. Amiodarone alone and hypothyroidism alone had similar action potential-prolonging actions. Hypothyroid animals treated with amiodarone showed a combination of ionic effects (strong IKs reduction, similar to hypothyroidism alone; reduced IKr and IK1, similar to amiodarone alone), along with action potential prolongation significantly greater than that caused by either intervention alone. We conclude that chronic amiodarone and hypothyroidism have different effects on ionic currents and that their combination prolongs action potential duration to a greater extent than either alone in guinea pig hearts, suggesting that the class III actions of amiodarone are not mediated by a cardiac hypothyroid state.  (+info)

Amiodarone versus propafenone for conversion of chronic atrial fibrillation: results of a randomized, controlled study. (5/719)

OBJECTIVES: The purpose of this study was to investigate the efficacy and safety of amiodarone and propafenone in the conversion of chronic atrial fibrillation in a prospective, randomized, placebo-controlled study. BACKGROUND: The effectiveness of amiodarone and propafenone in the treatment of patients with chronic atrial fibrillation has not been adequately studied. METHODS: One hundred one patients (48 men, mean age 64 +/- 9 years) with atrial fibrillation lasting >3 weeks participated in the study. Thirty-four patients received amiodarone (300 mg intravenously over 1 h, followed by 20 mg/kg over the next 24 h plus 600 mg orally, in three doses, for 1 week, then 400 mg/day orally, for three weeks), 32 received propafenone (2 mg/kg intravenously over 15 min, followed by 10 mg/kg over 24 h and then 450 mg/day orally, for one month) and the remaining 35 served as control subjects. All patients received digoxin and anticoagulant treatment as indicated (International Normalized Ratio 2 to 3). RESULTS: Conversion to sinus rhythm was achieved in 16 (47.05%) patients who received amiodarone, in 13 (40.62%) who received propafenone and in none of the control subjects (p < 0.001 for both groups vs. control subjects). Those who converted had smaller atria than those who did not and atrial fibrillation of shorter duration in both the amiodarone and propafenone groups. Treatment was discontinued in one patient of the propafenone group because of significant QRS widening. CONCLUSIONS: Amiodarone and propafenone appear to be safe and equally effective in the termination of chronic atrial fibrillation. Left atrial diameter and arrhythmia duration are independent predictors of conversion.  (+info)

Effect of intravenous amiodarone on electrophysiologic variables and on the modes of termination of atrioventricular reciprocating tachycardia in Wolff-Parkinson-White syndrome. (6/719)

Atrioventricular reciprocating tachycardia (AVRT) associated with the Wolff-Parkinson-White (WPW) syndrome, sometimes terminates spontaneously, generally sustains and eventually becomes drug resistant. Amiodarone is a potent antiarrhythmic drug that is sometimes effective in patients with AVRT which is resistant to conventional antiarrhythmic drugs. However, systematic studies concerning the effects of amiodarone on AVRT have not been reported. This study evaluated the effects of intravenous amiodarone on electrophysiologic variables, and on the sites and the modes of termination of AVRT. Fifteen WPW patients were studied. Nine had overt, and 6 had concealed WPW syndrome. Measurements of electrophysiologic variables and the induction of AVRT were performed by atrial and/or ventricular programmed stimulations. Amiodarone was then administered at a dose of 5 mg/kg over 5 min. The effective refractory periods (ERP) of the atrial, atrioventricular node, ventricular and accessory pathway were increased significantly by amiodarone. The conduction times of all the components were significantly lengthened by amiodarone, except for the His-ventricular (HV) interval in concealed WPW patients. AVRT was induced in all patients, and was terminated by amiodarone in 12 of 13 patients with sustained AVRT. After amiodarone, AVRT was induced in 9 patients. Spontaneous termination was observed 11 times in 3 of the 9 patients in whom AVRT was still induced. In these cases, the modes and sites of termination were the same as during the baseline state. The ERPs and conduction times of all components of AVRT, except the HV interval, were significantly lengthened by amiodarone. Amiodarone is efficacious for terminating AVRT wherever weak links exist. However, sites of spontaneous termination are not significantly affected by amiodarone.  (+info)

Comparison of sotalol with amiodarone for long-term treatment of spontaneous sustained ventricular tachyarrhythmia based on coronary artery disease. (7/719)

AIM: To compare the efficacy of sotalol versus amiodarone for long-term treatment of ventricular tachyarrhythmias. METHODS: Patients (n=75) with spontaneous, sustained ventricular tachyarrhythmias secondary to remote myocardial infarction were studied. After intravenous electrophysiological testing, both sotalol and amiodarone were predicted to be ineffective in 50 (67%) patients. Five patients were excluded. Forty-five patients were randomized to receive sotalol (n=22) or amiodarone (n=23) for maintenance therapy. The primary outcome variable was the time to first recurrence of sustained ventricular tachyarrhythmia. RESULTS: At 36 months. 75% of those allocated sotalol remained free of ventricular tachyarrhythmia compared with 38% of those allocated amiodarone (P=0.05). On multivariate analysis the risk of recurrence of ventricular tachyarrhythmia for patients on amiodarone was 5.9 times higher (P=0.008) than that for patients on sotalol. CONCLUSION: Sotalol is superior to amiodarone for long-term treatment of ventricular tachyarrhythmia secondary to coronary artery disease when both drugs have been predicted to be ineffective at intravenous electrophysiological testing. Randomized trials in larger numbers of patients with ventricular tachyarrhythmia need to be performed comparing the two agents directly.  (+info)

Amiodarone compared with iodine exhibits a potent and persistent inhibitory effect on TSH-stimulated cAMP production in vitro: a possible mechanism to explain amiodarone-induced hypothyroidism. (8/719)

Amiodarone (AMD) is a powerful anti-arrhythmic drug used for the treatment of a wide variety of cardiac arrhythmias and its most striking feature is its high iodine content. Thyroid dysfunction is a limiting side-effect of the drug and both AMD-induced hypothyroidism (AIH) and AMD-induced thyrotoxicosis (AIT) are reported. To examine the hypothesis that altered bioavailability of iodine is a contributing event in the pathogenesis of AIH, we compared the effects of AMD and inorganic iodine in vitro on events involved in the process of thyroid autoregulation. FRTL-5 cells and JP26 CHO cells (transfected with the human TSH receptor) were exposed to AMD or NaI in the presence of TSH, and cAMP production was measured as an indicator of cellular function. Forskolin and cholera toxin were also used to determine the possible target sites of AMD and iodide. Our results indicated that there was a difference between the effects of AMD versus those of physiological doses of iodide. The inhibitory effects of AMD occurred at lower concentrations of iodide than those seen in the NaI-treated cells. The effects of AMD were irreversible indicating a possible persistence of the Wolff-Chaikoff effect due to a constant high intracellular iodide level. The inhibitory effects of AMD (also seen at supraphysiological doses of iodide) were partially overcome by forskolin but not by cholera toxin indicating an effect on TSH receptor interactions with the other signal transduction elements such as G proteins and adenylate cyclase. The persistence of the Wolff-Chaikoff effect through loss of autoregulation may be a mechanism of the observed hypothyroidism in some patients taking AMD. The combined effects of the constant release of iodide together with the drug toxicity may be the mechanism for the observed effects.  (+info)

*Amiodarone

Since amiodarone can be expressed in breast milk, women taking amiodarone are advised to stop nursing. It is contraindicated in ... Amiodarone is structurally similar to thyroxine and also contains iodine. Both of these contribute to the effects of amiodarone ... Amiodarone has numerous side effects. Most individuals administered amiodarone on a chronic basis will experience at least one ... Side effects of amiodarone include various pulmonary effects. The most serious reaction that is due to amiodarone is ...

*Cornea verticillata

It is seen in Fabry disease or in case of prolonged amiodarone intake. No ocular complaints or visual difficulty is usually ... Chew, E; Ghosh, M; McCulloch, C (June 1982). "Amiodarone-induced cornea verticillata". Canadian journal of ophthalmology. ...

*Krukenberg's spindle

Chew, E; Ghosh, M; McCulloch, C (June 1982). "Amiodarone-induced cornea verticillata". Canadian journal of ophthalmology. ... caused by chronic amiodarone use for cardiac arrhythmias. Non-transparent collagen deposits appearing following loss of corneal ...

*Anosmia

Amiodarone is a drug used in the treatment of arrhythmias of the heart. A clinical study performed demonstrated that the use of ... Although rare, there was a case in which a 66-year-old male was treated with Amiodarone for ventricular tachycardia. After the ... "Anosmia induced by amiodarone". The American Journal of Medicine. 120 (11): e9. doi:10.1016/j.amjmed.2006.08.029. PMID 17976411 ... the severity of the anosmia decreased accordingly hence correlating the use of Amiodarone to the development of anosmia. Upper ...

*Fabry disease

Chew, E.; Ghosh, M.; McCulloch, C. (June 1982). "Amiodarone-induced cornea verticillata". Canadian Journal of Ophthalmology. 17 ...

*Domperidone

QT-prolonging drugs like amiodarone. Prolactin secreting pituitary tumor (prolactinoma) or hyperprolactinemia. Mechanical bowel ...

*AV nodal reentrant tachycardia

... these include flecainide or amiodarone. Both adenosine and beta blockers may cause tightening of the airways, and are therefore ...

*Benzbromarone

Amiodarone Benziodarone Dronedarone Sinclair, DS; Fox, IH (1975). "The pharmacology of hypouricemic effect of benzbromarone". ... Kumar, V.; Locuson, CW; Sham, YY; Tracy, TS (2006). "Amiodarone Analog-Dependent Effects on CYP2C9-Mediated Metabolism and ... It is structurally related to the antiarrhythmic amiodarone. Benzbromarone is highly effective and well tolerated, and clinical ...

*Polysorbate 80

"Pharmaceutical amiodarone composition for parenteral delivery". Retrieved 2008-04-06. Pandemic H1N1 (pH1N1) Influenza Vaccine ... and used as an emulsifier in the manufacture of the popular antiarrhythmic amiodarone. It is also used as an excipient in some ...

*Epididymitis

Chemical epididymitis may also result from drugs such as amiodarone. Diagnosis is typically based on symptoms. Conditions that ... Ibsen HH, Frandsen F, Brandrup F, Møller M (August 1989). "Epididymitis caused by treatment with amiodarone". Genitourin Med. ...

*Rearrest

These drugs may include lidocaine and amiodarone. Rearrest may reduce the likelihood of survival when compared to patients who ...

*FIASMA

These 20 included amiodarone and etidronic acid. FIASMAs are structurally diverse, but have common physicochemical properties. ... Alverine Amiodarone Amitriptyline Amlodipine Aprindine Astemizole AY-9944 Benzatropine Bepridil Biperiden Camylofin Carvedilol ...

*Celivarone

The non-iodinated nature of celivarone means that the harmful side-effects on the thyroid commonly seen with amiodarone therapy ... Amiodarone Benzbromarone Benziodarone Budiodarone Dronedarone Gautier, P; Guillemare, E; Djandjighian, L; Marion, A; ... Celivarone is a non-iodinated benzofuran derivative, structurally related to amiodarone, a drug commonly used to treat ... "Dose Ranging Study of Celivarone with Amiodarone as Calibrator for the Prevention of Implantable Cardioverter Defibrillator ( ...

*Restrictive lung disease

Certain drugs such as amiodarone, bleomycin and methotrexate. As a consequence of another disease such as rheumatoid arthritis ...

*Orlistat

... can also impair absorption of the antiarrhythmic amiodarone. The MHRA has recently suggested that Orlistat could ... amiodarone, fluoxetine, and simvastatin) in healthy volunteers". J Clin Pharmacol. 43 (4): 428-35. doi:10.1177/0091270003252236 ...

*Budiodarone

Amiodarone to prevent recurrence of atrial fibrillation. N Engl J Med. 2000;342:913-920 Singh, B.N., et al. Amiodarone versus ... This side chain allows for budiodarone to have a shorter half-life in the body than amiodarone (7 hours versus 35-68 days) ... Amiodarone is considered the most effective antiarrhythmic drug available, but its adverse side effects, including hepatic, ... Low dose amiodarone and sotalol in the treatment of recurrent, symptomatic atrial fibrillation: a comparative, placebo ...

*Potassium channel blocker

Amiodarone is indicated for the treatment of refractory VT or VF, particularly in the setting of acute ischemia. Amiodarone is ... Amiodarone was the first agent described in this class. Amiodarone should only be used to treat adults with life-threatening ... Amiodarone prolongation of the action potential is uniform over a wide range of heart rates, so this drug does not have reverse ... 2008). "Relationship among amiodarone, new class III antiarrhythmics, miscellaneous agents and acquired long QT syndrome". ...

*Cardiac arrest

Lidocaine and amiodarone are also deemed reasonable in children with cardiac arrest who have a shockable rhythm. The general ... Neither lidocaine nor amiodarone, in those who continue in ventricular tachycardia or ventricular fibrillation despite ... Sanfilippo, F; Corredor, C; Santonocito, C; Panarello, G; Arcadipane, A; Ristagno, G; Pellis, T (October 2016). "Amiodarone or ... This includes the use of epinephrine, atropine, lidocaine, and amiodarone. Epinephrine is generally recommended every five ...

*Primidone

CYP2C8 substrates such as amiodarone, paclitaxel, pioglitazone, repaglinide, and rosiglitazone; and CYP2C9 substrates such as ...

*Implantable cardioverter-defibrillator

Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005 Jan 20;352(3):225-37 ... Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005; 352:225-237 Stevenson ... Quality of life with defibrillator therapy or amiodarone in heart failure. N Engl J Med 2008; 359(10):999-1008 Rivera NT, Bray ... "Quality of life with defibrillator therapy or amiodarone in heart failure". N Engl J Med. 359 (10): 999-1008. doi:10.1056/ ...

*Goitrogen

Amiodarone inhibits peripheral conversion of thyroxine to triiodothyronine; also interferes with thyroid hormone action.[ ...

*Artesunate

These drugs include amiodarone, desipramine, isoniazid, ketoconazole, letrozole, methoxsalen, tranylcypromine. The mechanisms ...

*Autoimmune hypophysitis

... amiodarone-induced hypothyroidism". Hosp Med. 61 (1): 64-5. PMID 10735160. Minakshi B, Alok S, Hillol KP (2005). "Lymphocytic ...

*Artificial cardiac pacemaker

"Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure". N. Engl. J. Med. 352 (3): 225-37. doi: ...

*Thyroid disease

Amiodarone (more commonly can lead to hypothyroidism, but can be associated with some types of hyperthyroidism) Lithium salts ( ... "Thyroid Function Abnormalities during Amiodarone Therapy for Persistent Atrial Fibrillation". The American Journal of Medicine ...
Hyperthyroidism or hypothyroidism may occur in patients taking amiodarone.2 Amiodarone can interfere with thyroid function due to iodine in the medicine blocking the conversion of T4 to T3.2 A 200 mg tablet of amiodarone will yield approximately 40 times the recommended 150 microgram daily intake of iodine in a patient in steady state metabolism.5, 10 Altered thyroid function tests in the first three months of treatment are common.4. Hyperthyroidism is reported to be the most frequent amiodarone-induced adverse effect in New Zealand recorded by the Centre for Adverse Reaction Monitoring (CARM).8 This can develop rapidly and patients may present with a new arrhythmia.8 If patients taking amiodarone develop tachycardia or atrial fibrillation their thyroid function should be retested.8 If a patient has elevated T3 and T4 levels with very low or undetectable TSH levels this is consistent with thyrotoxicosis and amiodarone should be temporarily withdrawn.8 Carbimazole may be initiated to block ...
Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhythmias and atrial fibrillation. The drug prevents the recurrence of life-threatening ventricular arrhythmias and produces a modest reduction of sudden deaths in high-risk patients. Amiodarone is more effective than sotalol or propafenone in preventing recurrent atrial fibrillation in patients for whom a rhythm-control strategy is chosen. When long-term amiodarone therapy is used, potential drug toxicity and interactions must be considered. The dosage of amiodarone should be kept at the lowest effective level. In patients who also are taking digoxin and warfarin, physicians must pay close attention to digoxin levels and prothrombin time, keeping in mind that the effects of interaction with amiodarone do not peak until seven weeks after the initiation of concomitant therapy. Laboratory studies to assess liver and thyroid function should be performed at least every six months.
BACKGROUND: In the ENGAGE AF-TIMI 48 trial, the higher-dose edoxaban (HDE) regimen had a similar incidence of ischaemic stroke compared with warfarin, whereas a higher incidence was observed with the lower-dose regimen (LDE). Amiodarone increases edoxaban plasma levels via P-glycoprotein inhibition. The current pre-specified exploratory analysis was performed to determine the effect of amiodarone on the relative efficacy and safety profile of edoxaban.. METHODS AND RESULTS: At randomization, 2492 patients (11.8%) were receiving amiodarone. The primary efficacy endpoint of stroke or systemic embolic event was significantly lower with LDE compared with warfarin in amiodarone treated patients vs. patients not on amiodarone (hazard ratio [HR] 0.60, 95% confidence intervals [CIs] 0.36-0.99 and HR 1.20, 95% CI 1.03-1.40, respectively; P interaction ,0.01). In patients randomized to HDE, no such interaction for efficacy was observed (HR 0.73, 95% CI 0.46-1.17 vs. HR 0.89, 95% CI 0.75-1.05, P ...
Title: Dronedarone: A Safety Comparison to Amiodarone. VOLUME: 5 ISSUE: 3. Author(s):James R. Clem, Debra K. Farver, Janet R. Fischer and Thomas J. Johnson. Affiliation:South Dakota State University College of Pharmacy, 4801 North Career Avenue, Sioux Falls, SD 57107, USA.. Keywords:Dronedarone, SR 33589, amiodarone, atrial fibrillation, safety. Abstract: Dronedarone is an oral Class III antiarrhythmic agent which was recently approved by the US Food and Drug Administration for use in nonpermanent atrial fibrillation. Structurally similar to amiodarone, dronedarone is a benzofuran derivative but it lacks the iodine moiety attached to amiodarone. Based upon the investigational clinical trials to date, it appears that dronedarone has an established efficacy when compared to placebo along with exhibiting a minimal adverse effect profile. The efficacy of dronedarone will need to be further evaluated in comparison trials with established antiarrhythmics for atrial fibrillation. The adverse profile of ...
In patients with coronary artery disease and reduced ejection fraction, amiodarone reduces mortality by decreasing sudden cardiac death. Since the latter may be triggered by coronary artery thrombosis as much as ventricular arrhythmias, amiodarone might interfere with tissue factor (TF) expression and thrombus formation. Clinically relevant plasma concentrations of amiodarone inhibited TF activity and carotid artery thrombus formation in a mouse photo-chemical injury model in vivo (n = 5; p , 0.035; Figure 1). In human endothelial and vascular smooth muscle cells, amiodarone inhibited tumor necrosis factor-α and thrombin induced TF protein expression (n = 4; p , 0.001) as well as surface activity (n = 4; p , 0.0001). Tissue factor pathway inhibitor was not affected (n = 5; p = NS). Amiodarone lacking iodine as well as the main metabolite of amiodarone, N-monodesethylamiodarone, inhibited TF expression (n = 4; p, 0.01). Amiodarone did not affect mitogen activated protein kinase activation(n = 3; ...
1. Kumar K, Zimetbaum PJ. Antiarrhythmic drugs 2013: state of the art. Current cardiology reports. 2013;15:410 2. Thorne SA, Barnes I, Cullinan P. et al. Amiodarone-associated thyroid dysfunction: risk factors in adults with congenital heart disease. Circulation. 1999;100:149-154 3. Vorperian VR, Havighurst TC, Miller S. et al. Adverse effects of low dose amiodarone: a meta-analysis. Journal of the American College of Cardiology. 1997;30:791-798 4. Harjai KJ, Licata AA. Effects of amiodarone on thyroid function. Annals of internal medicine. 1997;126:63-73 5. Tisdale JE, Follin SL, Ordelova A. et al. Risk factors for the development of specific noncardiovascular adverse effects associated with amiodarone. Journal of clinical pharmacology. 1995;35:351-356 6. Waldhauser KM, Torok M, Ha HR. et al. Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives. The Journal of pharmacology and experimental therapeutics. 2006;319:1413-1423 7. Yamazaki K, Mitsuhashi T, ...
A number of studies have demonstrated an improvement in left ventricular EF or clinical heart failure end points with amiodarone therapy.1 2 3 Cleland et al1 reported an improvement in central hemodynamics with amiodarone therapy in patients with heart failure, but their study was small and nonrandomized. Hamer et al2 found an increase in both EF and exercise tolerance in a prospective, randomized trial. However, both of these studies were small, and harder clinical end points were not examined. Furthermore, unlike the present study, background vasodilator therapy was not consistently used.. The most important previous study of amiodarone in patients with CHF is the Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA) trial.3 In GESICA, in contrast to the Veterans Affairs trial, all-cause mortality was reduced by 28% (P,.03), and sudden death mortality was reduced by 27% (P=.056). For comparison with the present study, the most relevant findings from GESICA were ...
The effect of long-term treatment with amiodarone on patients with Chagas disease has seldom been reported. This nonrandomized observational study attempted to analyze the follow-up of patients with Chagas disease regarding their clinical evolution, thyroid dysfunction, and goiter. We compared 72 patients with long-term use (11 +/- 5 years) of amiodarone, including 22 patients who developed goiter, to 33 patients who did not use amiodarone, followed-up for 2 to 20 years (7 +/- 11 years). Follow-up of 72 patients for 9 +/- 5.4 years with periodic cardiac and thyroid function evaluations showed that only 26 maintained normal serum thyrotropin (TSH) levels; 24 presented with elevated levels; 4 had low levels, and 18 patients presented with fluctuations of TSH level. Among the 22 patients with goiter, only 3 (14%) patients maintained normal TSH, 8 (36%) had elevated TSH, 2 (9%) had low TSH, and 9 (41%) patients presented with fluctuating serum TSH levels. Most individuals remained clinically ...
A amiodarona, usada no tratamento de arritmias cardíacas, está associada com disfunção tiroideana. Não existem relatos sobre sua freqüência no sudeste do Brasil e nem estudos avaliando a utilidade de scores clínicos para o diagnóstico de anormalidades tiroideanas nesses pacientes. Este estudo visou determinar a prevalência de disfunções tiroideanas induzidas pela amiodarona numa amostra representativa de um centro teciário, para estudar as condições associadas a esta disfunção e para avaliar a confiabilidade de scores clínicos para hipo e hipertiroidismo. Avaliação clínica e laboratorial foi realizada em 195 pacientes em uso de amiodarona; desses, 2,1% tinha hipertiroidismo, 25,1% hipotiroidismo e 9,2% tinha apenas um T4 elevado. Considerando as variáveis pesquisadas de disfunção tiroideana, a autoimunidade tiroideana estava associada positivamente (OR 4,8; p= 0,02), e o sexo masculino teve uma tendência para associação positiva (OR 1,86; p= 0,06). Os scores clínicos ...
Standard dual chamber pacing was first used as adjunctive treatment for severe congestive heart failure in the early 1990s.1 It was proposed that a short atrioventricular delay reduced presystolic mitral regurgitation.2,3 It also may correct chronotropic incompetence and protect against fatal bradyarrhythmias.. We performed a randomised study to test whether DDDR pacing with optimised atrioventricular (AV) delay and reversal of drug induced bradycardia by rate responsive pacing was beneficial in heart failure patients who were receiving combined treatment with amiodarone and β blockers as empirical prophylaxis against sudden tachyarrhythmic death.4. In 82 patients with severe heart failure submitted for heart transplantation and without a conventional pacemaker indication between 1996 and 1998 (85% male; 52% idiopathic dilated cardiomyopathy), treatment with low dose amiodarone (1000 mg/week) plus titrated doses of carvedilol (target 50 mg/day) was instituted. In addition, a dual chamber ...
The long QT syndrome is characterized by prolongation of the QT interval and by the occurrence of life-threatening tachyarrhythmias.1 It can be familial or acquired. We report a case of acquired QT prolongation and life-threatening ventricular arrhythmias caused by amiodarone therapy that was being given for treatment of. Abstract. Amiodarone is an antiarrhythmic agent known to cause prolongation of action potential duration which is reflected in the electrocardiogram as a prolongation of the QT interval. Prolongation of the QT interval in patients dying suddenly was compared with that in patients who remained alive to determine whether a.. Amiodarone is an antiarrhythmic agent known to cause prolongation of action clinical duration which is needed in the clearance as a prolongation of the QT erin. Prolongation of the QT interval in areas dying suddenly was compared with that in patients who remained alive to see whether a patient. Bradycardia and difficulty block occur in 1 to 3 amiodarone ...
Introduction: Class I antiarrhythmic drugs increase duration of the excitable gap (EG) during typical atrial flutter whereas intravenous class III drugs decrease the EG. The effect of chronic oral amiodarone therapy on the EG is unknown. Methods and Results: EG was prospectively determined by introducing a premature stimulus and analyzing the response pattern during typical atrial flutter in 30 patients without antiarrhythmic drugs and in 20 patients under chronic oral amiodarone therapy. EG was calculated by the difference between the longest coupling interval leading to resetting and the effective atrial refractory period (EARP). A fully EG was defined by the portion of EG where the response curve of the return cycles was flat. A partially EG was defined by the portion of EG where the return cycle increases while coupling interval decreases. A resetting response curve was constructed by plotting the duration of the return cycle against the value of the coupling interval. Cycle length (CL; 222 ...
4. "Ive been on amiodarone for over a year. It works for me and keeps me out of A-Fib. But Im worried about the toxic side effects. What should I do?". You are correct to be concerned about toxic effects. Amiodarone is considered one of the most effective antiarrhythmic meds, but its also one of the most toxic. It may affect your lungs, eyes, thyroid, liver, skin, heart, and nervous system.. Also, amiodarone has a long half-life. It is retained in the body for up to 45 days after the drug has been discontinued.. (Be advised that a newer drug dronedarone (brand name Multaq) is now on the market and may be a good substitute for amiodarone. Dronedarone may not be quite as effective as amiodarone, but is much safer. However, some studies indicate that dronedarone may have problems.). If you are taking amiodarone, you should by monitored and tested frequently and scrupulously for damage to your organ systems (your doctor may already be doing this). You should keep copies of any tests. Whats ...
X 200 mg side effects obat 200 mg atorvastatin generic price in malaysia cordarone 100 medicine toxicity icd 9 code. 200 mg dosage 300 mg iv amiodarone without benzyl.. People who have ventricular arrhythmias may receive 400 mg of amiodarone to help stabilize the heartbeat.Hydrochloride 100 mg short term use amiodarone 450 mg monitoring uk icd 9.. Price walmart 150 mg bolus can you drink alcohol and take hydrochlorothiazide amiodarone 100 mg 6 months.Amiodarone 200 mg-EON. Pacerone 100 mg. round, yellow, imprinted with P, U-S 144.Pacerone (100 mg, 200 mg) (amiodarone hydrochloride) - Drug Summary Upsher-Smith Laboratories, Inc.Infusion protocol australia price tab decadron 8 mg 100mg amiodarone hydrochloride mechanism and side effects. 400 mg bid hydrochloride tablets 200 mg cordarone 150 ...
Amiodarone is a commonly used anti-arrhythmic agent, with well-recognized chronic toxicity. Less well known is amiodarones potential to cause acute lung damage, which can be severe or, occasionally, life-threatening. Lungs that have already been exposed to physical insults, such as the lungs of patients undergoing cardiac surgery, are particularly susceptible to acute pulmonary toxicity (APT). Unfortunately, cardiac surgery is one of the clinical scenarios in which amiodarone is most commonly used. After reviewing the data, and even in the context of difficulties and discrepancies in the existing literature, we contend that there is sufficient evidence of amiodarones potentially serious side-effect profile in surgical ICU patients to advise continued caution in its use with this severely ill patient group. We suggest that amiodarone has a potentially important, though underrecognized, role in inducing an APT/ARDS in some patients, such as those undergoing cardiac surgery. We also provide a hypothesis
Amiodarone is a unique and complex drug with multiple effects. It is difficult to determine which of its effects might be related to our findings. In contrast to many antiarrhythmic drugs, amiodarone has been effective in several patient groups and has not been associated with increased mortality ([8]). Its most obvious direct electrophysiologic effect is prolongation of the action potential duration and repolarization time (class III antiarrhythmic effect). Despite an association of QT prolongation with malignant ventricular arrhythmias, amiodarone is the antiarrhythmic agent that has the least proarrhythmic effect, possibly due to more uniform prolongation of myocardial repolarization resulting in a decrease of QT dispersion ([15-18]). Sudden death reduction in patients with high heart rates may be explained by an antiarrhythmic or antifibrillatory effect. However, an antiarrhythmic effect does not account for all of our findings.. In the present study functional capacity improved, hospital ...
A placebo-controlled study of i.v. amiodarone in patients with supraventricular arrhythmias and 2 to 3-consecutive-beat ventricular arrhythmias, and a pharmacokinetic/pharmacodynamic study evaluating rapid i.v. loading in patients with recurrent, refractory ventricular tachycardia (VT)/ ventricular fibrillation (VF) have shown rapid onset of antiarrhythmic activity well before significant blood levels of desethylamiodarone (DEA) were present; approximately 1500 mg/day of i.v. amiodarone were administered using 2- and 3-stage infusion regimens.
Clinical record. A 73-year-old man presented with recurrent ventricular tachycardia (VT) on a background of severe, non-ischaemic dilated cardiomyopathy (ejection fraction, 20%) and cardiac resynchronisation therapy with an implantable cardioverter defibrillator (ICD). Over the previous 6 months, he had frequent appropriate ICD shocks for VT after unsuccessful antitachycardia pacing. A coronary angiogram was normal. Amiodarone had been successful in reducing VT burden and ICD shocks, but was ceased because of amiodarone-induced thyrotoxicosis. Shortly after discontinuing amiodarone, there was a significant increase in VT burden and appropriate ICD shocks. An endocardial mapping and VT ablation procedure had been performed, but this was unsuccessful and suggested an epicardial source of VT. The patient also underwent subsequent epicardial mapping and VT ablation using a CARTO 3 (Biosense Webster) electroanatomical mapping system, which localised the source of VT to a diffuse area of the basal ...
BACKGROUND: Dronedarone is a new antiarrhythmic drug that is being developed for the treatment of patients with atrial fibrillation. METHODS: We conducted a multicenter trial to evaluate the use of dronedarone in 4628 patients with atrial fibrillation who had additional risk factors for death. Patients were randomly assigned to receive dronedarone, 400 mg twice a day, or placebo. The primary outcome was the first hospitalization due to cardiovascular events or death. Secondary outcomes were death from any cause, death from cardiovascular causes, and hospitalization due to cardiovascular events. RESULTS: The mean follow-up period was 21+/-5 months, with the study drug discontinued prematurely in 696 of the 2301 patients (30.2%) receiving dronedarone and in 716 of the 2327 patients (30.8%) receiving placebo, mostly because of adverse events. The primary outcome occurred in 734 patients (31.9%) in the dronedarone group and in 917 patients (39.4%) in the placebo group, with a hazard ratio for ...
Ten RCTs (1,744 participants) were included.. Amiodarone decreased the incidence of atrial fibrillation or flutter (RR 0.64, 95% CI: 0.55, 0.75, P,0.001). This decrease was similar for both pre-operative and peri-operative treatment, and for oral and intravenous administration.. Amiodarone also decreased the incidence of ventricular tachycardia or fibrillation (RR 0.42, 95% CI: 0.28, 0.63, P,0.001). The results were similar when studies that did not differentiate between sustained and nonsustained ventricular tachycardia or fibrillation were removed (RR 0.34, 95% CI: 0.18, 0.66).. Amiodarone reduced the incidence of stroke (RR 0.39, 95% CI: 0.21, 0.76, P=0.005) and the length of hospital stay (WMD -0.63 days, 95% CI: -1.03, -0.23, P=0.002). No statistically significant differences in mortality were seen between the two treatment groups (RR 0.84, 95% CI: 0.43, 1.65), or in the incidence of MI (RR 0.71, 95% CI: 0.31, 1.62). There was no evidence of statistical heterogeneity or publication bias, ...
Patients randomized to vernakalant received a 10-minute infusion of 3 mg/kg vernakalant in one infusion line, followed by a 15-minute observation period and an additional 10-minute infusion of 2 mg/kg vernakalant if still in AF. To maintain blinding, a 60-minute infusion of placebo (5% dextrose in water) was administered in a second infusion line, followed by a maintenance infusion of placebo for an additional 60 minutes. Patients randomized to amiodarone received a 60-minute infusion of 5 mg/kg amiodarone in one infusion line, followed by a maintenance infusion of 50 mg amiodarone over an additional 60 minutes (equivalent to approximately 15 mg/kg over 24 hours). To maintain blinding, these patients received a 10-minute infusion of placebo (normal saline) in a second infusion line, followed by a 15-minute observation period and a second 10-minute infusion of placebo if still in AF ...
Amiodarone affects the rhythm of your heartbeats. Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat ventricular tachycardia or...
Amiodarone affects the rhythm of your heartbeats. Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat ventricular tachycardia or...
Amiodarone is an antiarrhythmic medication that affects the rhythm of heartbeats. Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat or...
During October 1, 2000 and September 30, 2002, 712 patients were considered for resuscitation and 566 were resuscitated. The initial rhythms were as follows: 32% had VF/VT, 36% had asystole and 32% had pulseless electrical activity (PEA). Of the 180 patients with VF/VT, 75 (42%) received undiluted amiodarone in addition to other resuscitative measures. Of the patients with asystole or PEA, 12 (6%) and 18 (10%), respectively, received amiodarone. The blood pressure levels and the need vasopressors after ROSC and during transportation to the hospital were similar among the patients who received and those who did not receive amiodarone. Conclusions ...
Establecidas en haut a las características farmacológicas y farmacocinéticas del principio activo, las que fueron confirmadas con estudios clínicos realizados. man, wind-stricken and thought to be taking, who was placed with the other intestinal for burial. He exhibited peers of life, and was taken back to the american- cataflam dosage forms when to administer amiodarone of silver. If we can have a day which is as needed to the time tissue as silver favor, and in addition to this leaflet when to administer amiodarone of generico. Wee que sirve el cataflam pediatrico gotas, cataflam uso topico, cataflam gotas novartis, preço do cataflam generico, cataflam gotas pediatricas pen que sirve. Para que es el medicamento cataflam dd, cataflam dosis niños 3 años, cataflam side oral dosis niños, cataflam 50 mg diclofenac kal, obat cataflam 50 mg diclofenac potassium, cataflam diclofenaco potasico 50 mg. Guidelines for the Administration of IV. Amiodarone. Clinical Guideline. Register No: Status: ...
Several anti-arrhythmic agents, which are used in treatment of AF, exist. However, the efficacy of these drugs still can be improved. Furthermore, some of them are associated with a wide range of adverse side effects. Therefore, the mechanisms of action of these agents have to be better understood and still can be optimized.. Dronedarone is an anti-arrhythmic agent used in the treatment of AF by maintaining sinus rhythm. It is a derivative of amiodarone and has been developed to reduce the side effects as e.g. thyroid toxicity of its precursor compound.. The aim of this work is to integrate the effects of dronedarone into a model of atrial electrophysiology. In this way, the mechanism of action, i.e. the anti-arrhythmic effects of this agent should be better understood. In previous work, the effects of amiodarone were already integrated into an atrial cell model. Finally, a comparison of both agents and their impact on healthy and electrically remodeled tissue shall be carried out. ...
At the time of the randomization telephone call to the Clinical Trial Center, the investigator reported whether the patient was eligible and agreed to randomization in the First Antiarrhythmic Drug Substudy. Patients randomized to the rhythm control arm of the main AFFIRM study then received a second randomization of the antiarrhythmic drug to be used in this substudy.. The substudy was designed to be three separate comparisons between two drugs: amiodarone versus class I agents, amiodarone versus sotalol, and sotalol versus class I agents. If a patient was eligible for all three drug arms, the randomization was performed among all three drug groups, and the patients data were added to the pool of data in two two-way comparisons. For example, a patient eligible for amiodarone, sotalol, and a class I agent might be randomized to amiodarone. His or her data would be included in the amiodarone arm of both the amiodarone versus class I comparison and in the amiodarone versus sotalol comparison. ...
In their interesting report on the "rapid and dramatic" reduction in ventricular arrhythmias in patients treated with oral amiodarone, Kim and colleagues [1] correctly point out the possible confounding effects of other antiarrhythmics administered early in the course of amiodarone loading. Despite this caveat, the graphs and P values presented appear impressive. However, several problems in the analysis may render the conclusion erroneous. First, use of analysis of variance (ANOVA) requires an implicit assumption of normally distributed data. No mention was made of data transformation (that is, logarithms), often used to reduce the influence of extreme values and approximate a normally distributed variance. In subsequent analyses, the authors used the Kruskal-Wallis test, a statistic useful for analysis of non-normally distributed data, but the required comparison with the chi-square distribution to test for significance was not cited [2]. In the absence of this and an F statistic for the ...
Discovered in 1961, amiodarone is a cationic amphiphilic molecule which belongs to class III antiarrhythmic drugs and therefore, it is used in the treatment of a wide range of cardiac arrhythmias. Advances in Medicine and Biology. Volume 136 begins by discussing state of the art formulations of amiodarone and outlooks for future dosage forms.. Though amiodarone hydrochloride has often been prescribed for patients with refractory or life-threatening arrhythmias, its clinical use is frequently limited because of a number of side effects such as corneal microdeposits, photosensitivity, pulmonary fibrosis, thyroid and liver dysfunction, and peripheral neuropathy. As such, the authors conduct a study wherein amiodarone hydrochloride dose-dependently induced cell death, lysosomal storage of phospholipids and neutral lipids, and oxidative stress in immortalized Schwann cells.. The following review presents scientific results and popular uses for plants from the Euphorbia genus. With nearly 2,000 ...
The mechanisms underlying the non-competitive β-antagonistic properties of amiodarone were investigated, and the haemodynamic responses to exercise following the administration of oral amiodarone or...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Amiodarone (Cordarone) is an antiarrhythmic medication used to treat ventricular tachycardia or ventricular fibrillation. Includes amiodarone side effects, interactions and indications.
Amiodarone is a commonly administered medication in the critical care. It is an antiarrhythmic drug that is used commonly to treat ventricular heart arrhythmias. Learn how to administer amiodarone and what to look out for as a nurse.
FDA Drug Safety Communication: FDA Warns of Serious Slowing of the Heart Rate When Antiarrhythmic Drug Amiodarone is Used with Hepatitis C Treatments Containing Sofosbuvir (Harvoni) or Sovaldi in Combination with Another Direct Acting Antiviral Drug." U.S. Food and Drug Administration, http://www.fda.gov/Drugs/DrugSafety/ucm439484.htm. Retrieved April 10, 2015.. "Full Prescribing Information." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_pi.pdf. Retrieved April 10, 2015. "Harvoni® Coupon and Savings." Gilead.com. Gilead Sciences, Inc., https://www.harvoni.com/co-pay-coupon-registration. Retrieved April 13, 2015.. "Patient Information: Harvoni®." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_patient_pi.pdf. Retrieved April 13, 2015. "Support Path Harvoni® and Sovaldi® Tablets Treatment Support." Gilead.com. Gilead Sciences, Inc., ...
The US Food and Drug Administration has warned of continued reports of a rare muscle injury when patients are concurrently treated with cholesterol drug simvastatin and antiarrhythmic drug amiodarone. - News - PharmaTimes
I was reading an article regarding Managing Afib in Annals of EM. They are recommending Amiodarone 300 mg IV over an hour and then 10-50 mg/hour for 24 hour.. I thought something wrong with this, but I checked their reference and it is correct. So, dont be surprise of dose of 300 mg in alive patient!. Amiodarone is a very invasive IV medication and I believe we have to use other options before we get to this dose!. 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary. ...
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest, which one is your choice? The 2015 update of ACLS is still recommending Amio in Vfib, VTach Cardiac arrest after Shock and Epi, But new study in NEJM proved that among 3026 patients who randomized to Amiodarone (974), Lidocaine (993), or Placebo (1059), there were no statistically significant rate of survival to hospital discharge or favorable neurologic outcome.. Link to article. ...
As discussed in this eMedTV page, combining amiodarone with certain products can cause potentially life-threatening problems. This resource takes a detailed look at some of the many amiodarone drug interactions that can occur and how to minimize problems.
This video shows a cornea with amiodarone verticillata deposits. You can see these as a whorl pattern - the entity is also called whorl keratopathy or hurricane keratopathy. These deposits are benign, difficult to see, and rarely (if ever) have any visual significance.. Drugs that can cause this pattern: CACTI Mneumonic: chloroquine, amiodarone, chlorpromazine, tamoxifen, indomethacin.. In addition, you can presumably get a similar pattern with amodiaquine, meperidine, and with Fabrys disease.. ...
1 Answer - Posted in: coricidin, amiodarone, interaction - Answer: Amiodarone interacts with about 500 drugs. The drug you mention is listed ...
Initial intravenous (IV) dose of 3 mg/kg (up to a maximum of 339 mg) over 10 minutes, followed by a 15 minute observation period and, if conversion to sinus rhythm does not occur within 15 minutes of the initial infusion, a second 10 minute infusion of vernakalant at a dose of 2 mg/kg (up to a maximum of 226 mg) will be administered ...
Dronedarone improves microvascular flow during atrial fibrillation and reduces the infarct size in acute models of myocardial infarction. However, dronedarone might be harmful in patients with recent decompensated heart failure and increases mortality in patients with permanent atrial fibrillation. A pathophysiological explanation for these discrepant data is lacking. This study investigated the effects of dronedarone on gene and protein expression in the infarcted area and border zone in pigs subjected to anterior ischemia/reperfusion myocardial infarction. The ischemia/reperfusion myocardial infarction was induced in 16 pigs. Eight pigs were treated with dronedarone for 28 days after myocardial infarction, the remaining pigs served as control. Microarray-based transcriptome profiling and 2D-DIGE-based proteome analysis were used to assess the effects of dronedarone on left ventricular gene expression in healthy (LV), infarcted (MI), and border zone tissue. Selected targets were validated by ...
I am a 70 year old male, and have been in A Fib for the past two months. In addition a echocardiogram has shown damage to my heart muscle. I have hypothyroidism (essentially no thyroid function) an...
1 cm2) and atrial fibrillation (AF) were evaluated. All patients underwent transthoracic electrical DC cardioversion under amiodarone treatment. Nineteen of the 22 patients were successfully converted to sinus rhythm (SR). The patients were evaluated with transthoracic echocardiography before and two to three days after DC cardioversion. In order to deal with variable R-R intervals, the measurements were averaged on five to eight consecutive beats in AF. Cn was calculated with a previously validated equation [Cn (mL/mm Hg)=1.270 x MVA/E-wave downslope]. The Cn difference between AF and SR was calculated as follows: [(AF Cn−SR Cn)/AF Cn] x 100. The percentage gradient (mean or maximal) difference between AF and SR was calculated as follows: [AF gradient (mean or maximal) SR gradient (mean or maximal)]/[AF gradient (mean or maximal)] x 100 ...
Clinically, one can divide AF into presentations where treatment priorities differ between rhythm control on the one hand and stroke prevention on the other. Usually, rhythm control is a priority in emergency departments, where intravenous or loading-dose oral medications are required, and a relevant outcome is acute conversion. Stroke prevention is a priority when cardioversion is more "elective," and a separate strategy for reducing stroke risk is used before conversion. In this context, the need for intravenous cardioversion medication is less clear. These issues are especially relevant to amiodarone, an agent with pharmacologic properties that differ when given orally and intravenously. Many of these concerns were addressed by the a priori subgroup analysis by duration of AF done by Letelier and colleagues. An analysis based on these priorities would have been more informative but probably not easily done in this complicated data set. In patients with AF ≤ 48 hours, the placebo or control ...
Amiodarone belongs to a class of drugs called Vaughan-Williams Class III antiarrhythmic agents. It is used in the treatment of a wide range of cardiac tachyarhthmias, including both ventricular and supraventricular (atrial) arrhythmias. After intravenous administration in man, amiodarone relaxes vascular smooth muscle, reduces peripheral vascular resistance (afterload), and slightly increases cardiac index. Amiodarone prolongs phase 3 of the cardiac action potential. It has numerous other effects however, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone shows beta blocker-like and calcium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects ...
Beta-blockers have been proved to increase the survival of people with heart failure. It is not entirely clear how this occurs, but it is suspected that a major factor is their ability to prevent ventricular arrhythmias. Beta-blockers can be very effective at preventing single abnormal beats of the heart muscle, called premature ventricular contractions, which experts think are a common trigger of ventricular arrhythmias. These beneficial effects have been observed for essentially all beta-blockers. The ability of beta-blockers to prevent ventricular arrhythmias further emphasizes why all people with heart failure should be taking them.. Of equal importance, beta-blockers do not have any pro-arrhythmic effects, even in people with very abnormal left ventricular function. When a medicine increases the occurrence of arrhythmias, it is said to have a "pro-arrhythmic" effect. Amiodarone is an antiarrhythmic medicine. Amiodarone may not be useful for everyone with heart failure. Although amiodarone ...
The authors of the AVRO study also assert that, while both treatments were found to be safe and well tolerated, vernakalant had "low proarrhythmic potential and provides a rapidly acting therapeutic alternative".. The research team, led by Professor John Camm from St. Georges University of London, conducted a randomized, double-blind, multicenter superiority trial in 254 adult patients with underlying cardiovascular disease, making certain antiarrhythmic drugs inappropriate for use. 116 patients in each group received at least one dose of the study drug. Approximately 30% of patients in both treatment arms had no AF episodes prior to the initial diagnosis, whereas one-third had at least three.. Those in the vernakalant study arm received a 10-minute infusion of 3 mg/kg followed by an additional 10-minute infusion of 2 mg/kg if needed after a 15-minute observation period. Amiodarone patients received a 60-minute infusion of 5 mg/kg followed by an additional 60-minute maintenance infusion of 50 ...
Adding IV Amiodarone to the EMS Algorithm for Cardiac Arrest Due to VF/Pulseless VT Introduction Before the year 2000, the traditional antiarrhythmic agents (lidocaine, bretylium, magnesium sulfate, procainamide,
Two hundred and thirty-two patients (mean age 63 years) with AF lasting 3-48 hours in duration were randomly assigned to one of two intravenous therapies: vernakalant, 3 mg/kg over 10 minutes, then an additional 10-minute infusion of 2 mg/kg if necessary 15 minutes later (n = 116); amiodarone 5 mg/kg over 60 minutes, then 50 mg over an additional 60 minutes (n = 116). The study was double-blinded. The primary endpoint was conversion to sinus rhythm (SR) within 90 minutes of first exposure to the study drug.. ...
... Cordarone is used to treat ventricular tachycardia or ventricular fibrillation by blocking certain electrical signals in the heart that can cause an irregular heartbeat.
Pronunciation guide (phonetic spelling and recorded audio) of amiodarone, also known as Cordarone; Pacerone, which is a Top 250 Drug in the drug class of Antiarrhythmic (class III).
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Available as tablets or an injection, amiodarone is given to help control certain heart rhythm problems. This eMedTV selection features details on how this medication is administered and general dosing instructions. It also links to more information.
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While there are several general principles for initiating, monitoring, and responding to. amiodarone, Beta-adrenergic agonists e.g. epinephrine
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Parkinsonian syndrome occurs secondary to some other disease or disorder, including brain tumors, drugs, toxins, encephalitis or head trauma. For example, brain damage sustained from repeated blows to the head or from certain drugs can damage the dopaminergic cells and lead to the symptoms of primary Parkinsons disease.. In particular, drugs that act on the dopamine system within the brain, including anti-psychotics, some antidepressants, calcium channel blockers, the anti-arrhythmic drug amiodarone as well as many illicit drugs can all induce Parkinsonism over time.. The good news is that no matter the cause of Parkinsons disease and symptoms, the underlying neurotransmitter deficit can be overcome using the proper blend of amino acids and co-factors to restore optimal neurotransmitter function utilizing the neurons that have not yet been destroyed.. ...
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance ...
Tacrolimus, digoxin, and statin medications may cause potentially serious dronedarone drug interactions. This eMedTV page lists other medicines that may interfere with dronedarone and explains what problems may occur if these drugs are taken together.
Amiodarone is a drug used to slow the heart rate and help keep it in a regular rhythm. It is used to treat fast or other irregular heartbeats, called arrhythmias, including atrial fibrillation, ventricular tachycardia and ventricular fibrillation. Amiodarone belongs to a class of drugs called antiarrhythmics. Side effects are usually dose-related and regular follow-up is necessary to evaluate kidney, liver and lung function.. ...
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Buy cheap Generic Cardarone online without prescription. Cardarone is used in treatment of irregular heartbeat and to maintain a normal heart rate (ventricular fibrillation and ventricular tachycardia).
Avoid sun exposure; Interacts with grapefruit juice; Regular blood test, ECGs, chest X-rays; Tell doctor shortness of breath, dry cough, vision problems, weight loss, muscle weakness; Perform eye examination annually ...
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My parents left him in the emergency room earlier, before he was attacked by an SVT, after which, my parents received a call from the hospital asking them to come. The attending doctor gave him a lot of anti-arrhythmic drugs (amiodarone, digoxin and adenosine) within the one hour. Basically, he had a cocktail of strong anti-arrhythmic drugs pumped into his 14 year old thin body in just one hour. According to him, he had 3 attacks that night. And when the drug was pumped into him, he felt his heart stopped for a while, he went unconscious for a second and then came back to life (this was his description ...
Durn it! Dronedarone, the Atrial Fibrillation drug that has been highlighted here before, isnt living up to the hype. It was already known that it is not as effective as Amiodarone, but it doesnt have the side effects that drug has. The hope was that if you developed A-Fib at an early age, or have…
Mylan-Amiodarone: Amiodarone belongs to the family of medications known as antiarrhythmics. It is used to treat certain types of abnormal heart rhythms (arrhythmias). It works by changing how electrical impulses affect the heart muscle and by making the heart beat more regularly. The effects of this medication may be noted as early as 3 days after starting treatment, but it is usually 1 to 3 weeks before beneficial effects are seen.
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E 0471 [MW 436, E 047/1], a benzo[b]furanyl compound derived from amiodarone, was developed by Ebewe Pharmaceuticals. It was undergoing phase II clinical
Amiodarone is the antiarrhythmic drug of choice in treatment of patients suffering from acute tachyarrhythmias and haemodynamic instability due to impaired cardiac function. The intravenous form of amiodarone hydrochloride (IvAm) has individual antiarrhythmic, rate-controlling efficacy, and the dosage is empirical. The main adverse effects are hypotension, severe bradycardia, asystole, acute heart failure, and impaired liver function. Acute liver failure (ALF) is a known but rare complication of IvAm that may be reversible by eliminating the infusion in most cases. The few papers in the literature suppose ALF may be caused by polysorbate 80, the vehicle of IvAm. Oral administration does not to have such an adverse effect, therefore IvAm can be changed to oral form in any cases. ...
TOPIC: Amiodarone-induced thyrotoxicosis Title: Amiodarone-induced thyrotoxicosis is a predictor of adverse cardiovascular outcome . Authors: Yiu K-H, Jim M-H, Lee C-H, Yuen M, Mok M, Shea Y-F, Fan K, Tse H-F, & Chow W-H. Reference: Journal of Clinical Endocrinology and Metabolism 94: 109-114, 2009 Summary Background Whether the risk of long-term major adverse cardiovascular events […]. ...
It is well known that amiodarone is effective for the treatment of atrial fibrillation. However, effects of amiodarone on the muscarinic acetylcholine receptor-operated K+ current (IK.ACh), which plays an important role in the repolarization of atrial action potential, have not been evaluated. This study was undertaken to determine whether amiodarone inhibits the acetyl-choline-sensitive muscarinic K+ (KACh) channel by use of the patch-clamp technique. In isolated guinea pig atrial cells, IK.ACh was activated by extracellular application of carbachol (1 microM) or adenosine (10 microM) or by the intracellular loading of GTP gamma S (100 microM). Amiodarone inhibited the IK.ACh activated in these three different ways with similar IC50 values around 2 microM, which indicated that amiodarone directly depresses the function of the KACh channel itself and/or GTP-binding proteins. Single KACh channel current was also recorded by use of a pipette solution containing carbachol (1 microM) or atropine (10 ...
Czarnywojtek A, Czarnocka B, Zgorzalewicz-Stachowiak M, Wolinski K, Fichna M, Plazinska M, Stangierski A, Gut P, Miechowicz I, Komarowska H, Waligorska-Stachura J, Wasko R, Ruchala M. The role of antithyroglobulin, antiperoxidase and anti-TSH receptor autoantibodies in amiodarone-induced thyrotoxicosis and amiodarone-induced hypothyroidism (A two-center study). Neuro Endocrinol Lett. 2015 Dec; 36(7): 677-681 ...
Czarnywojtek A, Czarnocka B, Zgorzalewicz-Stachowiak M, Wolinski K, Fichna M, Plazinska M, Stangierski A, Gut P, Miechowicz I, Komarowska H, Waligorska-Stachura J, Wasko R, Ruchala M. The role of antithyroglobulin, antiperoxidase and anti-TSH receptor autoantibodies in amiodarone-induced thyrotoxicosis and amiodarone-induced hypothyroidism (A two-center study). Neuro Endocrinol Lett. 2015 Dec; 36(7): 677-681 ...
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An electrolyte imbalance (such as low doses of potassium or magnesium in your pee); or. if you have a potential or defibrillator implanted in your general. Do not use amiodarone if you are known. Taking this penjual misoprostol di jogja during pregnancy can prevent the unborn baby or cause thyroid hormones or abnormal. We describe the generic of long QT interval and scared ventricular tachycardia in a patient treated penjual misoprostol di jogja amiodarone who did with of both as abnormal when we take into account that the majority of softeners cited as having amiodarone-induced torsade de las had also potassium depletion. Amiodarone is saw as a class III antiarrhythmic agent, and dogs phase 3 of the cardiac action limited, the repolarization phase where there is normally dosed calcium permeability and increased potassium were. More:. ...
A "pill-in-the-pocket" rhythm-control treatment strategy is acceptable as initial therapy for patients who are quite symptomatic with new-onset paroxysmal AF and no structural heart disease.1 This strategy involves a larger, 1-time dose of a class I antiarrhythmic (propafenone or flecainide). A fast-acting atrioventricular nodal blocking agent such as metoprolol should be used in conjunction to prevent concealed conduction that can progress to ventricular tachycardia or fibrillation. First-time administration requires observation and is usually performed by a cardiologist. Pill-in-the-pocket dosing for flecainide and propafenone can be found in Table 5.1,4,17-19. Dronedarone has received increased attention as a novel agent for the treatment of arrhythmias in the hope of finding a safer alternative to amiodarone therapy. According to data from the ATHENA20 (A Placebo-controlled, Double Blind, Parallel-arm Trial to Assess the Efficacy of Dronedarone 400 mg BID for the Prevention of Cardiovascular ...
More.Gerber, M. NURR1- deficient cocaine abusers also had dopamine neurons with markedly reduced dopamine transporter gene expression. Amiodarone-induced thyrotoxicosis in the setting of a rare patient with otherwise intractable arrhyth- mia is an indication for thyroidectomy.
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This eMedTV segment contains a detailed list of products that may cause complications when combined with amiodarone premixed injection, including lidocaine and trazodone. A description of the problems these drug interactions can cause is also included.
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Atrial Fibrillation patients often search for unbiased information and guidance about medicines and drug therapy treatments. These are answers to the most frequently asked questions by patients and their families. (Click on the question to jump to the answer.). 1. " I have a heart condition. Which medications are best to control my Atrial Fibrillation?" What medications work best for me?". 2. HRT: "Do you have information about Hormone Replacement Therapy (HRT) and if it might help or hinder my atrial fibrillation?". 3. Rate Control Drug: "I take atenolol, a beta-blocker. Will it stop my A-Fib.". Antiarrhythmic Drugs. 1. "Is the "Pill-In-The-Pocket" treatment a cure for A-Fib? When should it be used?" ("Pill-In-The-Pocket" makes use of an antiarrhythmic drug such as flecainide). 2. "Ive been on amiodarone for over a year. It works for me and keeps me out of A-Fib. But Im worried about the toxic side effects. What should I do?". 3. "Is the antiarrhythmic drug Multaq [dronedarone] safer than ...
Sensitivity of the skin to a light source can take various forms. People with particular skin types are more sensitive to sunburn. Particular medications make the skin more sensitive to sunlight; these include most of the tetracycline antibiotics, heart drugs amiodarone, and sulfonamides. Particular conditions lead to increased light sensitivity. Patients with systemic lupus erythematosus experience skin symptoms after sunlight exposure; some types of porphyria are aggravated by sunlight. A rare hereditary condition xeroderma pigmentosum (a defect in DNA repair) is thought to increase the risk of UV-light-exposure-related cancer by increasing photosensitivity ...
1. What is the rhythm demonstrated on the EKG?. 2. How would you manage this patient?. ANSWER:. The rhythm is ventricular tachycardia. The patient is stable so he can be managed medically. However, this patient was managed with overdrive pacing. See below.. The rhythm is a wide complex tachycardia at a rate of ~160. In emergency medicine we always assume a wide complex tachycardia is V-tach. That is especially true in a patient with a history of CHF and especially true in a patient with an ICD. (Remember that an ICD is placed because the patient is at high risk for developing V-tach). This rhythm was confirmed to be V-tach.. If the patient was unstable, the treatment would be electrical cardioversion. Since the patient is stable, they can be treated with medications such as amiodarone. However, this patient was already on amiodarone. Other options include lidocaine or procainamide.. However, this patient has an ICD in place which presents other treatment options. In the words of a recent ...
One thing that emerged in the planning of the event was that two of the booklet contributors, Olivia Huntingdon-Stuart ("The Age of Athena") and Houman Sadri ("Synthesising male and female aspects of war in Azzarello and Chiangs Wonder Woman"), were engaging in Athena-related research with lots of interfaces - and from different disciplinary starting-points. Olivia is now planning a follow-up event, titled *The Age of Athena* which will explore gender norms and non-binary concepts via the vehicle of Athena ...
DO NOT TAKE THIS MEDICINE if you are also taking gemfibrozil, HIV protease inhibitors (such as ritonavir, lopinavir, nelfinavir), azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as erythromycin, clarithromycin, or troleandomycin), or nefazodone. If you are currently taking any of these medicines, tell your doctor or pharmacist before taking this medicine. additional monitoring OF your dose OR condition may be needed if you are taking amiodarone, "blood thinners" (such as warfarin), fibrates (such as clofibrate or fenofibrate), bosentan, cyclosporine, dalfopristin or quinupristin, digoxin, diltiazem, fluconazole, imatinib, high doses of niacin {1 gram or more per day), rifamycins such as rifampin, St. Johns wort, verapamil, or voriconazole. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including kidney problems, muscle problems, alcohol use, allergies (especially to other ...
CIDS is the fourth reported randomized controlled trial that compared ICDs with antiarrhythmic drugs in recent years. The other 3 studies were the AVID (Antiarrhythmics versus Implantable Defibrillators) trial (1), the MADIT (Multicenter Automatic Defibrillator Implantation Trial) (2), and the CASH (Cardiac Arrest Study Hamburg) trial (3). CIDS allocated 600 patients to either ICD or amiodarone therapy. The current economic analysis limited itself to the first 430 patients. CIDS showed a small, statistically nonsignificant mortality advantage for patients in the ICD group, but the cost-benefit analysis showed a very high cost per year-of-life saved by ICDs. The authors concluded that ICD implantation was not cost-effective in these patients. Several points should be made about this study relative to its predecessors. First, the patient populations in these trials have been different. For example, the CIDS patients had resuscitated VF, VT, or unmonitored syncope, whereas the CASH patients had all ...
Primary adrenal lymphoma is a rare malignancy. It frequently presents bilaterally and with symptoms of adrenal insufficiency. Amiodarone may induce secondary organ dysfunction, and thyrotoxicosis develops in 15% of cases. The symptomatology of both conditions is nonspecific, especially in the elderly, and a high suspicion index is necessary for appropriate diagnosis. A 78-year-old female presented to the emergency department with confusion, nausea and vomiting. She had recently been to the emergency department with urinary tract infection, vomiting and acute hypochloremic hyponatremia. Upon re-evaluation, the leukocyturia persisted and because of TSH 0.01 µU/mL and free-T4 68 (10-18) pmol/L, she was admitted to the Endocrinology ward. Further evaluation supported amiodarone-induced thyroiditis type 2. Sepsis ensued, in the setting of nosocomial pneumonia. Hemodynamic instability, hyponatremia, hypoglycemia and vomiting raised the suspicion of adrenocortical insufficiency. Fluid resuscitation ...
Photosensitivity is the amount to which an object reacts upon receiving photons, especially visible light. In medicine, the term is principally used for abnormal reactions of the skin, and two types are distinguished, photoallergy and phototoxicity. The photosensitive ganglion cells in the mammalian eye are a separate class of light-detecting cells from the photoreceptor cells that function in vision. Sensitivity of the skin to a light source can take various forms. People with particular skin types are more sensitive to sunburn. Particular medications make the skin more sensitive to sunlight; these include most of the tetracycline antibiotics, heart drugs amiodarone, and sulfonamides. Some dietary supplements, such as St. Johns Wort, include photosensitivity as a possible side effect. Particular conditions lead to increased light sensitivity. Patients with systemic lupus erythematosus experience skin symptoms after sunlight exposure; some types of porphyria are aggravated by sunlight. A rare ...
Ventricular fibrillation (V-fib or VF) is when the heart quivers instead of pumping due to disorganized electrical activity in the ventricles. It is a type of cardiac arrhythmia. Ventricular fibrillation results in cardiac arrest with loss of consciousness and no pulse. This is followed by death in the absence of treatment. Ventricular fibrillation is found initially in about 10% of people in cardiac arrest. Ventricular fibrillation can occur due to coronary heart disease, valvular heart disease, cardiomyopathy, Brugada syndrome, long QT syndrome, electric shock, or intracranial hemorrhage. Diagnosis is by an electrocardiogram (ECG) showing irregular unformed QRS complexes without any clear P waves. An important differential diagnosis is torsades de pointes. Treatment is with cardiopulmonary resuscitation (CPR) and defibrillation. Biphasic defibrillation may be better than monophasic. The medication epinephrine or amiodarone may be given if initial treatments are not effective. Rates of survival ...
Isabelle C. Van Gelder, M.D., Vincent E. Hagens, M.D., Hans A. Bosker, M.D., J. Herre Kingma, M.D., Otto Kamp, M.D., Tsjerk Kingma, M.Sc., Salah A. Said, M.D., Julius I. Darmanata, M.D., Alphons J.M. Timmermans, M.D., Jan G.P. Tijssen, Ph.D., Harry J.G.M. Crijns, M.D., for the Rate Control versus Electrical Cardioversion for Persistent Atrial Fibrillation Study Group ABSTRACT Background Maintenance of sinus rhythm is the main therapeutic goal in patients with atrial fibrillation. However, recurrences of atrial fibrillation and side effects of antiarrhythmic drugs offset the benefits of sinus rhythm. We hypothesized that ventricular rate control is not inferior to the maintenance of sinus rhythm for the treatment of atrial fibrillation.. Methods We randomly assigned 522 patients who had persistent atrial fibrillation after a previous electrical cardioversion to receive treatment aimed at rate control or rhythm control. Patients in the rate-control group received oral anticoagulant drugs and ...
INJECTION, ADENOSINE, 6 MG (NOT TO BE USED TO REPORT ANY ADENOSINE PHOSPHATE INJECTION, ADENOSINE, 90 MG (NOT TO BE USED TO REPORT ANY ADENOSINE PHOSPHATE INJECTION, ADRENALIN, EPINEPHRINE, UP TO 1 ML AMPULE INJECTION, ALATROFLOXACIN MESYLATE, 100 MG INJECTION, METHYLDOPATE HCL, UP TO 250 MG INJECTION, ALPHA 1 - PROTEINASE INHIBITOR - HUMAN, 10 MG INJECTION, AMIODARONE HYDROCHLORIDE, 30 MG INJECTION, AMPHOTERICIN B, ANY LIPID FORMULATION, 50 MG INJECTION, AMPHOTERICIN B LIPID COMPLEX, 10 MG INJECTION, AMPHOTERICIN B CHOLESTERYL SULFATE COMPLEX, 10 MG INJECTION, AMPHOTERICIN B LIPOSOME, 10 MG INJECTION, AMPICILLIN SODIUM/SULBACTAM SODIUM, PER 1.5 GM INJECTION, SUCCINYLCHOLINE CHLORIDE, UP TO 20 MG INJECTION, METARAMINOL BITARTRATE, PER 10 MG INJECTION, CHLOROQUINE HYDROCHLORIDE, UP TO 250 MG INJECTION, ATROPINE SULFATE, UP TO 0.3 MG INJECTION, BACLOFEN, 50 MCG FOR INTRATHECAL TRIAL INJECTION, BENZTROPINE MESYLATE, PER 1 MG INJECTION, BETHANECHOL CHLORIDE, MYOTONACHOL OR URECHOLINE, UP TO 5 MG ...
Eighteen consecutive cases of fetal tachycardia referred to the department of Pediatric Cardiology, Uppsala University, were studied retrospectively. All cases were detected at a routine visit at an antenatal clinic. None of the cases had a structural heart disease. Fetal supraventricular tachycardia was found in 8 cases and atrial flutter in 10 cases. In 7 cases, hydrops and heart failure were diagnosed. Antenatal treatment with digoxin, alone or in combination with other antiarrhythmic drugs, was needed in 15 cases. In 10 cases an obvious effect of the therapy was observed. No intrauterine deaths occurred. One infant died postnatally. At birth, 4 infants were in need of neonatal intensive care when delivered. Antiarrhythmic treatment was started in 13 cases postnatally. Late relapse of tachycardia was reported in 3 children. In 1 of these cases the prenatal tachycardia had resolved spontaneously and the infant was not treated antenatally nor during the neonatal period. Although fetal ...
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Amiodarone: MedlinePlus Drug InformationAmiodarone: MedlinePlus Drug Information

Amiodarone: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Amiodarone comes as a tablet to take by mouth. It is usually taken once or twice a day. You may take amiodarone either with or ... Amiodarone can cause fetal harm.. *tell your doctor if you are breastfeeding. Do not breastfeed while you are taking amiodarone ... Before taking amiodarone,. *tell your doctor and pharmacist if you are allergic to amiodarone, iodine, any other medications, ...
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Amiodarone/prednisone | SpringerLinkAmiodarone/prednisone | SpringerLink

A case series described two boys and one girl [not all ages at the time of reaction onset stated] who developed amiodarone ... This was followed by maintenance therapy with oral amiodarone, which involved a loading dose of 200mg twice daily for three ... Diagnosis and Clinical Course of Three Adolescents with Amiodarone-Induced Hyperthyroidism. Pediatric Cardiology 39: No. 7, Oct ... He started receiving IV amiodarone 150mg [frequency not stated] and underwent electric cardioversion. ...
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Amiodarone pulmonary toxicity.  - PubMed - NCBIAmiodarone pulmonary toxicity. - PubMed - NCBI

Amiodarone pulmonary toxicity.. Marchlinski FE, Gansler TS, Waxman HL, Josephson ME.. Abstract. Pulmonary toxicity may occur in ... With cessation of amiodarone therapy and treatment with corticosteroids, clinical symptoms and radiographic abnormalities ... association with amiodarone hydrochloride therapy. The clinical features of the pulmonary involvement are mild dyspnea, ...
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Amiodarone drip | allnursesAmiodarone drip | allnurses

My patient was on amiodarone via a left mid lower forearm site. Natrecor was infusing via the left hand. ... Curious to know if anyone else has noticed a delayed reaction to amiodarone drip. ... Curious to know if anyone else has noticed a delayed reaction to amiodarone drip.. My patient was on amiodarone via a left mid ... Amiodarone appears to be the drug of choice as of late. What bothers me is that there is no significant literature on possible ...
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AmiodaroneAmiodarone

... Systematic (IUPAC) name (2-butylbenzofuran-3-yl)- [4-(2-diethylaminoethoxy)- 3,5-diiodo-phenyl]- ... However, amiodarone can be useful in shock-refractory VF. In the ARREST trial, amiodarone was shown to improve survival to ... Amiodarone can worsen the cardiac arrhythmia brought on by Foxglove poisoning. Metabolism. Amiodarone is extensively ... In December of 1985, amiodarone was approved by the FDA for the treatment of arrhythmias.[6] This makes amiodarone one of the ...
more infohttps://www.bionity.com/en/encyclopedia/Amiodarone.html

amiodarone therapy ?? - Heart Disease - MedHelpamiodarone therapy ?? - Heart Disease - MedHelp

amiodarone therapy ?? Howard__0 I am a 70 year old male, and have been in A Fib for the past two months. In addition a ... has precsribed amiodarone-presumably as a means of possibly restoring my normal sinus rythym. What I have read about amiodarone ... Amiodarone is a good medication for controlling afib, but as you know has many potential side effects. You will need good ... particularly with regard to adjusting other medications such as digoxin which may be affected by the amiodarone. I have ...
more infohttps://www.medhelp.org/posts/Heart-Disease/amiodarone-therapy-/show/868469

Side effects after quitting Amiodarone?Side effects after quitting Amiodarone?

... amiodarone, side effect, thyroid, breathing - Answer: What changed that you could stop it? If you are having more trouble ... ... Side effects after quitting Amiodarone?. Asked. 23 Dec 2014 by jipm57. Active. 24 Dec 2014. Topics. amiodarone, side effect, ... Side Effects of Amiodarone (detailed). Search for questions. Still looking for answers? Try searching for what you seek or ask ... My mother is having tons of side effects from Amiodarone Oral can she ween herself or stop cold?. Posted 3 Apr 2010 • 1 answer ...
more infohttps://www.drugs.com/answers/side-effects-after-quitting-amiodarone-2402876.html

DailyMed - AMIODARONE HYDROCHLORIDE tabletDailyMed - AMIODARONE HYDROCHLORIDE tablet

Amiodarone can harm your unborn baby. * Amiodarone can stay in your body for months after treatment is stopped. Talk with your ... Neither amiodarone nor its metabolite is dialyzable. The acute oral LD50 of amiodarone hydrochloride in mice and rats is ... are allergic to amiodarone, iodine, or any of the other ingredients in amiodarone hydrochloride tablets. See the end of this ... Neither amiodarone nor DEA is dialyzable.. In clinical studies of 2 to 7 days, clearance of amiodarone after intravenous ...
more infohttps://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=675d46cc-2185-4e47-b2a2-cdf052e010c3

DailyMed - AMIODARONE HYDROCHLORIDE tabletDailyMed - AMIODARONE HYDROCHLORIDE tablet

Amiodarone can harm your unborn baby. * Amiodarone can stay in your body for months after treatment is stopped. Talk with your ... Neither amiodarone nor its metabolite is dialyzable. The acute oral LD50 of amiodarone hydrochloride in mice and rats is ... are allergic to amiodarone, iodine, or any of the other ingredients in amiodarone hydrochloride tablets. See the end of this ... Neither amiodarone nor DEA is dialyzable.. In clinical studies of 2 to 7 days, clearance of amiodarone after intravenous ...
more infohttps://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ba2ccddb-b3f7-4a84-afd5-edbdbccf7bb3

Amiodarone Biologici Italia Laboratories - Drugs.comAmiodarone Biologici Italia Laboratories - Drugs.com

A list of US medications equivalent to Amiodarone Biologici Italia Laboratories is available on the Drugs.com website. ... Amiodarone Biologici Italia Laboratories is a medicine available in a number of countries worldwide. ... Amiodarone. Amiodarone hydrochloride (a derivative of Amiodarone) is reported as an ingredient of Amiodarone Biologici Italia ... Amiodarone Biologici Italia Laboratories. Amiodarone Biologici Italia Laboratories may be available in the countries listed ...
more infohttps://www.drugs.com/international/amiodarone-biologici-italia-laboratories.html

Amiodarone: uses & side-effects | PatientsLikeMeAmiodarone: uses & side-effects | PatientsLikeMe

Find treatment reviews for Amiodarone from other patients. Learn from their experiences about effectiveness, side effects and ... Stopped taking Amiodarone Duration. Patients. Percentage. This item is relevant to you: Less than 1 month 2 * 11% ... Currently taking Amiodarone Duration. Patients. Percentage. This item is relevant to you: 2 - 5 years 1 * 50% ... Why patients stopped taking Amiodarone. Multiple reasons could be selected. Reason. Patients. Percentage. This item is relevant ...
more infohttps://www.patientslikeme.com/treatments/detail/amiodarone

Amiodarone FlashcardsAmiodarone Flashcards

What is the mechanism of amiodarone?. Definition. Class III anti-arrhythmic blocker: blocks K channel (some B-Blocker activity ... How does amiodarone affect CYP enzymes?. Definition. Enzyme inhibitor (2C9 -amitryptyline; warfarin(S); Statins: fluvastatin, ... What are the counselling points for amiodarone?. Definition. Avoid sun exposure; Interacts with grapefruit juice; Regular blood ... What are the serious side effects associated with amiodarone?. Definition. Pulmonary toxicity, neurotoxicity, benign corneal ...
more infohttps://www.flashcardmachine.com/amiodarone2.html

Dangers of amiodarone and anticoagulant treatment. | The BMJDangers of amiodarone and anticoagulant treatment. | The BMJ

Dangers of amiodarone and anticoagulant treatment. Br Med J (Clin Res Ed) 1981; 283 :58 ... Dangers of amiodarone and anticoagulant treatment.. Br Med J (Clin Res Ed) 1981; 283 doi: https://doi.org/10.1136/bmj.283.6283. ...
more infohttp://www.bmj.com/content/283/6283/58.3

Amiodarone: Pediatric Medication | Memorial Sloan Kettering Cancer CenterAmiodarone: Pediatric Medication | Memorial Sloan Kettering Cancer Center

Slow heartbeat and the need to get a pacemaker have happened when amiodarone was given with sofosbuvir and certain other ...
more infohttps://www.mskcc.org/cancer-care/patient-education/amiodarone-01

amiodarone (injection) - Adventist HealthCareamiodarone (injection) - Adventist HealthCare

Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ... ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat or... ... Amiodarone is an antiarrhythmic medication that affects the rhythm of heartbeats. ... How is amiodarone injection given?. Amiodarone is injected into a vein through an IV. Amiodarone injection is often given ...
more infohttps://www.adventisthealthcare.com/health/library/topic/?id=d00002v1

Uro-Septra (Amiodarone; Trimethoprim)Uro-Septra (Amiodarone; Trimethoprim)

C01BD01 - Amiodarone*J01EA01 - Trimethoprim. Pharmaceutical companies: manufacturers, researchers, developers, local ...
more infohttps://drugs-about.com/drugs-u/uro-septra.html

Adverse reactions during treatment with amiodarone hydrochloride. | The BMJAdverse reactions during treatment with amiodarone hydrochloride. | The BMJ

Adverse reactions during treatment with amiodarone hydrochloride. Br Med J (Clin Res Ed) 1983; 287 :503 ... Adverse reactions during treatment with amiodarone hydrochloride.. Br Med J (Clin Res Ed) 1983; 287 doi: https://doi.org/ ...
more infohttp://www.bmj.com/content/287/6390/503.4

amiodarone (oral) | PeaceHealthamiodarone (oral) | PeaceHealth

Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ... ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat ventricular ... What is amiodarone?. Amiodarone affects the rhythm of your heartbeats.. Amiodarone is used to help keep the heart beating ... Amiodarone takes a long time to completely clear from your body. You may continue to have side effects from amiodarone after ...
more infohttps://www.peacehealth.org/medical-topics/content/multum/d00002a1.html

amiodarone (oral) - WellSpan Health Libraryamiodarone (oral) - WellSpan Health Library

Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ... ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat ventricular ... What is amiodarone?. Amiodarone affects the rhythm of your heartbeats.. Amiodarone is used to help keep the heart beating ... Amiodarone takes a long time to completely clear from your body. You may continue to have side effects from amiodarone after ...
more infohttp://www.wellspan.org/health-library/Document.aspx?id=d00002a1

amiodarone (injection) - WellSpan Health Libraryamiodarone (injection) - WellSpan Health Library

Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ... ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat or... ... Amiodarone is an antiarrhythmic medication that affects the rhythm of heartbeats. ... How is amiodarone injection given?. Amiodarone is injected into a vein through an IV. Amiodarone injection is often given ...
more infohttp://www.wellspan.org/health-library/Document.aspx?id=d00002v1

Amiodarone Hydrochloride (Actavis) | healthdirectAmiodarone Hydrochloride (Actavis) | healthdirect

On this page about Amiodarone Hydrochloride (Actavis) you will find information relating to side effects, age restrictions, ... Amiodarone Hydrochloride (Actavis) is a medicine containing the active ingredient(s) amiodarone. On this page you will find out ... Active ingredient in this medicine: amiodarone. Over 65 years of age?. If you are over 65 years of age, there may be specific ... Amiodarone Hydrochloride (Actavis) 200 mg uncoated tablet, 30. Consumer Medicine Information leaflet:. No consumer medicine ...
more infohttps://www.healthdirect.gov.au/medicines/brand/amt,691381000168104/amiodarone-hydrochloride-actavis

Thyroid Dysfunction Induced by Amiodarone Therapy: Background, Pathophysiology, EpidemiologyThyroid Dysfunction Induced by Amiodarone Therapy: Background, Pathophysiology, Epidemiology

Amiodarone is a potent antiarrhythmic drug that is used to treat ventricular and supraventricular tachyarrhythmias. It is a ... Amiodarone causes a wide spectrum of effects on the thyroid.. * Amiodarone inhibits type 1 5-deiodinase enzyme activity, ... encoded search term (Thyroid Dysfunction Induced by Amiodarone Therapy) and Thyroid Dysfunction Induced by Amiodarone Therapy ... short-term amiodarone use can be safe. The study looked at the effects of 8 weeks of either amiodarone or placebo therapy in ...
more infohttps://emedicine.medscape.com/article/129033-overview

Amiodarone/dexamethasone/sparfloxacin | SpringerLinkAmiodarone/dexamethasone/sparfloxacin | SpringerLink

Amiodarone/dexamethasone/sparfloxacin. Phlebitis following medication error, adrenocortical insufficiency and photoallergic ... Amiodarone/dexamethasone/sparfloxacin. Reactions Weekly 1790, 26 (2020). https://doi.org/10.1007/s40278-020-74645-x ...
more infohttps://rd.springer.com/article/10.1007%2Fs40278-020-74645-x

Amiodarone Pulmonary Toxicity | Clinical Science | Portland PressAmiodarone Pulmonary Toxicity | Clinical Science | Portland Press

P A Adams, A J Wright, P A Corris, A R Morley, R W F Campbell, G J Gibson; Amiodarone Pulmonary Toxicity. Clin Sci (Lond) 1 ... Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle Clin Sci (Lond) (July, 2013) ... Regulation of α- and β -myosin heavy chain messenger RNAs in the rat myocardium by amiodarone and by thyroid status Clin Sci ( ... Effect of Amiodarone on erythrocyte Shape and Membrane Properties Clin Sci (Lond) (October, 1990) ...
more infohttps://portlandpress.com/clinsci/article-abstract/66/2/7P/94516/Amiodarone-Pulmonary-Toxicity?redirectedFrom=fulltext

Intravenous Amiodarone for Incessant Tachyarrhythmias in Children | CirculationIntravenous Amiodarone for Incessant Tachyarrhythmias in Children | Circulation

Intravenous amiodarone for life-threatening tachyarrhythmias in children and young adults. J Am Coll Cardiol. 1993; 22: 95-98. ... Amiodarone is safe and highly effective therapy for supraventricular tachycardia in infants. Am Heart J. 2001; 141: 105-110. ... Concentrations of amiodarone and DEA were used to characterize the PK profile for the 3 dose regimens. For all patients with PK ... Total exposure to amiodarone during the blinded phase of the study (study drug plus open-label IV rescue boluses) ranged from 6 ...
more infohttp://circ.ahajournals.org/content/112/22/3470
  • The antiadrenergic effect of amiodarone, however, is different from that of β-blocker drugs because it is noncompetitive and additive to the effect of β-blockers. (ahajournals.org)
  • Your doctor will monitor you carefully during this time and for as long as you continue to take amiodarone. (medlineplus.gov)
  • Your doctor will order certain tests, such as blood tests, X-rays, and electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and during your treatment to be sure that it is safe for you to take amiodarone and to check your body's response to the medication. (medlineplus.gov)
  • You may take amiodarone either with or without food, but be sure to take it the same way each time.Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. (medlineplus.gov)
  • How should I take amiodarone? (peacehealth.org)
  • You may take amiodarone with or without food, but take it the same way each time. (peacehealth.org)
  • Women who are pregnant or may become pregnant are strongly advised to not take amiodarone. (wikipedia.org)
  • Amiodarone prolongs the duration of the action potential of all cardiac fibers while causing minimal reduction of dV/dt (maximal upstroke velocity of the action potential). (nih.gov)
  • Amiodarone is considered to be a class III drug (Vaughan Williams classification), which indicates that it prolongs the QT interval. (aafp.org)
  • Amiodarone prolongs VT cycle length by 20% to 25% during long-term therapy. (ahajournals.org)
  • Taking amiodarone during pregnancy can harm the unborn baby or cause thyroid problems or abnormal heartbeats after the baby is born. (peacehealth.org)
  • Amiodarone may cause your arrhythmia (irregular heart rhythm) to worsen or may cause you to develop new arrhythmias. (medlineplus.gov)
  • Amiodarone is used to treat and prevent certain types of serious, life-threatening ventricular arrhythmias (a certain type of abnormal heart rhythm when other medications did not help or could not be tolerated. (medlineplus.gov)
  • Amiodarone is an antiarrhythmic agent (medication used for irregular heart beat) used for various types of tachyarrhythmias (fast forms of irregular heart beat), both ventricular and supraventricular (atrial) arrhythmias. (bionity.com)
  • Based on Singh's work, the Argentinian physician Dr. Mauricio Rosenbaum began using amiodarone to treat his patients who suffered from supraventricular and ventricular arrhythmias, with impressive results. (bionity.com)
  • Based on papers written by Dr. Rosenbaum developing Singh's theories, physicians in the United States began prescribing amiodarone to their patients with potentially life-threatening arrhythmias in the late 1970s. (bionity.com)
  • By 1980, amiodarone was commonly prescribed throughout Europe for the treatment of arrhythmias, but in the U.S. amiodarone remained unapproved by the Food and Drug Administration , and physicians were forced to directly obtain amiodarone from pharmaceutical companies in Canada and Europe. (bionity.com)
  • In December of 1985, amiodarone was approved by the FDA for the treatment of arrhythmias. (bionity.com)
  • In animals, amiodarone is effective in the prevention or suppression of experimentally induced arrhythmias. (nih.gov)
  • Amiodarone is an antiarrhythmic drug used to treat and prevent certain types of ventricular arrhythmias (abnormal heart rhythm). (patientslikeme.com)
  • Although the U.S. Food and Drug Administration (FDA) has labeled amiodarone only for the treatment of life-threatening ventricular arrhythmias, the drug also is used to treat atrial fibrillation. (aafp.org)
  • Amiodarone is approved for use in the secondary prevention of life-threatening ventricular arrhythmias. (aafp.org)
  • As amiodarone can have serious side effects, it is mainly recommended only for significant ventricular arrhythmias. (wikipedia.org)
  • Amiodarone has been used both in the treatment of acute life-threatening arrhythmias as well as the chronic suppression of arrhythmias. (wikipedia.org)
  • The major metabolite of amiodarone is desethylamiodarone (DEA), which is known to have antiarrhythmic properties. (aafp.org)
  • The relationship between plasma amiodarone concentrations and effect, as well as the contribution of the metabolite DEA, is not well established. (aafp.org)
  • 6 Amiodarone is deethylated to an active metabolite desethyl-amiodarone, concentrations of which exceed those of the parent compound during long-term therapy. (ahajournals.org)
  • 2 Amiodarone is highly lipid soluble and is stored in high concentrations in fat and muscle, as well as in the liver, lungs, and skin. (aafp.org)
  • There is also marked intersubject variability in plasma concentrations of amiodarone and desethyl-amiodarone concentrations associated with arrhythmic suppression. (ahajournals.org)
  • Amiodarone can pass into breast milk and may harm a nursing baby. (adventisthealthcare.com)
  • Amiodarone crosses the placenta and reaches measurable levels in breast milk. (aafp.org)
  • Since amiodarone can be expressed in breast milk, women taking amiodarone are advised to stop nursing. (wikipedia.org)
  • Amiodarone is more effective than sotalol or propafenone in preventing recurrent atrial fibrillation in patients for whom a rhythm-control strategy is chosen. (aafp.org)
  • 6 - 9 [Reference 6 -Evidence level A, meta-analysis] In these patients, amiodarone may be used as an adjunct to reduce the frequency of ICD shocks or to control atrial fibrillation in selected highly symptomatic patients. (aafp.org)
  • This article reviews the pharmacology, indications, adverse effects, and drug interactions of amiodarone, and outlines a strategy for surveillance of patients who are taking this drug. (aafp.org)
  • Amiodarone was initially developed in 1961 at the Labaz company, Belgium, by chemists Tondeur and Binon. (bionity.com)
  • Amiodarone was first made in 1961 and came into medical use in 1962 for chest pain believed to be related to the heart. (wikipedia.org)
  • Diagnosis and Clinical Course of Three Adolescents with Amiodarone-Induced Hyperthyroidism. (springer.com)
  • These changes should not require discontinuation of amiodarone as they are evidence of its pharmacological action, although amiodarone can cause marked sinus bradycardia or sinus arrest and heart block. (nih.gov)
  • The elimination half-life of amiodarone is highly variable and unusually long, averaging about 58 days. (aafp.org)
  • 5 Estimates of the elimination half-life of amiodarone vary, depending on how it has been measured. (ahajournals.org)
  • Amiodarone was initially developed 3 decades ago for angina. (ahajournals.org)
  • Amiodarone comes as a tablet to take by mouth. (medlineplus.gov)
  • Each pink, round, biconvex tablet, marked 'R-200' on one side and with a score notch on the other side, contains amiodarone HCl 200 mg. (medbroadcast.com)
  • The dosage of amiodarone should be kept at the lowest effective level. (aafp.org)
  • Amiodarone may also cause liver damage. (medlineplus.gov)
  • While using amiodarone, you will need frequent medical tests and chest x-rays to check your thyroid, vision, lungs, and liver function. (peacehealth.org)
  • In the mid 1980s, the European pharmaceutical companies began putting pressure on the FDA to approve amiodarone by threatening to cut the supply to American physicians if it were not approved. (bionity.com)
  • The area under the plasma concentration-time curve (AUC) and the peak plasma concentration (C max ) of amiodarone increased by 2.3 (range 1.7 to 3.6) and 3.8 (range 2.7 to 4.4) times, respectively, in the presence of food. (nih.gov)