Amiodarone

Anti-Arrhythmia Agents

Benzofurans

Atrial Fibrillation

Tachycardia

Tachycardia, Ventricular

Sotalol

Thyrotoxicosis

Ventricular Fibrillation

Arrhythmias, Cardiac

Electric Countershock

Propafenone

Electrocardiography

Tachycardia, Paroxysmal

Tachycardia, Ectopic Junctional

Amiodarone

Amiodarone induced thyrotoxicosis

HERG

Potassium channel blocker

CACNA2D2

Potassium channel

Cornea verticillata

Krukenberg's spindle

Anosmia

Simvastatin

Fabry disease

Budiodarone

Polysorbate 80

Sanofi

Epididymitis

Drug-induced QT prolongation

Pulmonary toxicity

Rearrest

FIASMA

Junctional tachycardia

Celivarone

Restrictive lung disease

Benzbromarone

Orlistat

Domperidone

Lithium (medication)

Technetium (99mTc) sestamibi

Cardiac arrest

Primidone

Implantable cardioverter-defibrillator

Cordarone4

• Amiodarone (Cordarone)Taking papaya extract by mouth along with amiodarone might increase the amount of amiodarone in the body. (nih.gov)
• Amiodarone (Cordarone)Grapefruit juice can increase how much amiodarone the body absorbs. (nih.gov)
• Amiodarone (Cordarone) Amiodarone might increase sensitivity to sunlight. (nih.gov)
• Amiodarone is available in tablets of 200 and 400 mg in generic forms and under the brand names of Cordarone and Pacerone. (nih.gov)

Risks of taking ami1

• Talk to your doctor about the risks of taking amiodarone. (medlineplus.gov)

Arrhythmias9

• In animals, amiodarone is effective in the prevention or suppression of experimentally induced arrhythmias. (nih.gov)
• Amiodarone may cause your arrhythmia (irregular heart rhythm) to worsen or may cause you to develop new arrhythmias. (medlineplus.gov)
• Amiodarone is used to treat and prevent certain types of serious, life-threatening ventricular arrhythmias (a certain type of abnormal heart rhythm when other medications did not help or could not be tolerated. (medlineplus.gov)
• Amiodarone in the treatment of arrhythmias]. (nih.gov)
• Amiodarone is highly effective in suppressing ventricular arrhythmias and in maintaining sinus rhythm in patients with atrial fibrillation. (nih.gov)
• Reserve amiodarone hydrochloride for patients with the indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity, some also life-threatening. (nih.gov)
• Amiodarone is used for the maintenance of sinus rhythm in patients with arrhythmias, but thyroid dysfunction (amiodarone-induced thyrotoxicosis (AIT) or amiodarone-induced hypothyroidism (AIH)) is a common adverse effect. (bioscientifica.com)
• Amiodarone (brand name: Pacerone) is a prescription drug used to treat atrial and ventricular cardiac arrhythmias. (dangerousdrugs.com)
• Amiodarone is generally used to treat life-threatening arrhythmias or to prevent or treat heart rhythm disorders in people at risk of heart attack and other serious complications. (verywellhealth.com)

Atrial fibrillation2

• Amiodarone is also used off-label for suppression of atrial fibrillation and maintenance of normal sinus rhythm after cardioversion. (nih.gov)
• Amiodarone may also be useful in the treatment of atrial fibrillation. (medscape.com)

Discontinuation of amiodarone2

• These changes should not require discontinuation of amiodarone as they are evidence of its pharmacological action, although amiodarone can cause marked sinus bradycardia or sinus arrest and heart block. (nih.gov)
• 1%) leading to discontinuation of amiodarone hydrochloride tablets include pulmonary toxicity, paroxysmal ventricular tachycardia, congestive heart failure, and elevation of liver enzymes. (nih.gov)

Take amiodarone5

• Your doctor will monitor you carefully during this time and for as long as you continue to take amiodarone. (medlineplus.gov)
• Your doctor will order certain tests, such as blood tests, X-rays, and electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and during your treatment to be sure that it is safe for you to take amiodarone and to check your body's response to the medication. (medlineplus.gov)
• You may take amiodarone either with or without food, but be sure to take it the same way each time.Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. (medlineplus.gov)
• Those who take amiodarone for over 6 months are also likely to develop small corneal deposits in the eye, which can cause vision to be blurred by a bluish spot. (drugsdb.com)
• Women who are breastfeeding should not take amiodarone, since the benzyl alcohol present in the drug may induce what is called "gasping syndrome" in newborns, which is often fatal. (drugsdb.com)

Nexterone1

• NEXTERONE (amiodarone HCl) - Introducing the first ready-to-use premixed amiodarone from Baxter Healthcare Corporation. (mayfairdrugs.com)

Hydrochloride Tablets1

• These highlights do not include all the information needed to use AMIODARONE HYDROCHLORIDE TABLETS safely and effectively. (nih.gov)

Arrhythmia5

• Amiodarone is a potent arrhythmia suppressing agent that has been clearly linked to several distinct forms of drug induced liver disease. (nih.gov)
• Amiodarone is typically given in high loading doses of 800 to 1600 mg daily, either intravenously or orally until the arrhythmia is controlled, and as maintenance oral doses for long term therapy of 200 to 600 mg daily. (nih.gov)
• Once adequate arrhythmia control is achieved, or if side effects become prominent, reduce amiodarone hydrochloride tablet dose to 600 to 800 mg/day for one month and then to the maintenance dose, usually 400 mg/day. (nih.gov)
• Amiodarone is a drug used to treat a condition known as cardiac arrhythmia . (verywellhealth.com)
• Because amiodarone is prescribed to prevent or treat serious complications of cardiac arrhythmia, its benefits will almost always outweigh the risks of increased cholesterol. (verywellhealth.com)

Antiarrhythmics2

• Amiodarone is in a class of medications called antiarrhythmics. (medlineplus.gov)
• Avoid coadministration of amiodarone with other antiarrhythmics and drugs known to prolong the QT interval. (nih.gov)

Intravenous administration1

• In animal studies and after intravenous administration in man, amiodarone relaxes vascular smooth muscle, reduces peripheral vascular resistance (afterload), and slightly increases cardiac index. (nih.gov)

Acute3

• After acute intravenous dosing in man, amiodarone may have a mild negative inotropic effect. (nih.gov)
• Amiodarone, a Class III antiarrhythmic agent, used in the treatment of supraventricular and ventricular tachyarrhythmias, may cause acute hepatitis. (zenodo.org)
• Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis. (cdc.gov)

Drugs2

• Amiodarone hydrochloride is a member of a new class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams' classification) effects. (nih.gov)
• We included patients with initial shockable rhythms who received the study drugs of amiodarone, lidocaine, or placebo before achieving return of spontaneous circulation. (nih.gov)

Benzofuran derivative2

• Amiodarone is a benzofuran derivative: 2-butyl-3-benzofuranyl 4-[2-(diethylamino)-ethoxy]-3,5-diiodophenyl ketone hydrochloride. (nih.gov)
• Amiodarone (a" mee oh' da rone) is an iodinated benzofuran derivative that is a structural analogue of thyroid hormone. (nih.gov)

Return of spontaneous circulation1

• How does amiodarone affect return of spontaneous circulation, survival, and neurological outcome following cardiac arrest? (rebelem.com)

Doses3

• The liver injury occurs more frequently with higher doses and prolonged therapy, and total cumulative dosage may be important as amiodarone can accumulate and can persist in liver tissue, even long after therapy is stopped. (nih.gov)
• A woman who took amiodarone with reducing doses of 600, 400 and 200 mg daily for one week at each dosage level during the last 3 weeks of pregnancy had milk amiodarone and desethylamiodarone levels of 0.5 to 1.8 mg/L and 0.4 to 0.8 mg/L, respectively, in 5 samples of colostrum obtained during days 2 and 3 postpartum. (nih.gov)
• You will receive your first few doses of amiodarone in a hospital setting where your heart can be monitored in case the medication causes serious side effects. (buystromectoln.com)

Hypothyroidism1

• It is also not uncommon for individuals to develop hypothyroidism or hyperthyroidism as a result of taking amiodarone. (drugsdb.com)

Desethylamiodarone7

• 7 , 8 ] Infant serum levels of amiodarone and desethylamiodarone may be useful for ruling out cardiac effects of the drug. (nih.gov)
• Amiodarone is an iodine-containing compound that is active and is also metabolized to the active metabolite desethylamiodarone. (nih.gov)
• In a mother who took amiodarone 200 mg daily for the last 5 weeks of pregnancy and for one week after delivery, milk amiodarone and desethylamiodarone levels were 0.55 and 0.44 mg/L, respectively, at 4 weeks postpartum and 0.030 and 0.002 mg/L at 6 weeks postpartum. (nih.gov)
• A mother who took amiodarone 200 mg daily throughout pregnancy and during breastfeeding had milk amiodarone and desethylamiodarone levels of 1.7 and 0.75 mg/L, respectively, 2 weeks postpartum and 3.0 and 1.8 mg/L 3 weeks postpartum. (nih.gov)
• Another mother who took amiodarone 200 mg daily throughout pregnancy had milk amiodarone and desethylamiodarone levels of 2.2 and 0.77 mg/L, respectively, at birth. (nih.gov)
• A woman who took amiodarone 400 mg daily from week 14 of pregnancy and throughout nursing had milk amiodarone levels that varied from 1.06 to 3.65 mg/L (average 2.52 mg/L) and milk desethylamiodarone levels that varied from 0.5 to 1.24 mg/L (average 0.9 mg/L) on 5 occasions during the month following delivery. (nih.gov)
• A woman who took amiodarone 800 mg daily for 1 week starting at week 34 of pregnancy, then 400 mg daily for the rest of her pregnancy and during breastfeeding had milk amiodarone levels that varied from 3.6 to 14.4 mg/L (average 10.4 mg/L) and milk desethylamiodarone levels that varied from 1.3 to 5.7 mg/L (average 4.1 mg/L) on days 9, 11 and 13 postpartum. (nih.gov)

Cardiac7

• Amiodarone prolongs the duration of the action potential of all cardiac fibers while causing minimal reduction of dV/dt (maximal upstroke velocity of the action potential). (nih.gov)
• Amiodarone increases the cardiac refractory period without influencing resting membrane potential, except in automatic cells where the slope of the prepotential is reduced, generally reducing automaticity. (nih.gov)
• In periarrest / cardiac arrest situations amiodarone has been given as a peripheral bolus countl. (bmj.com)
• Use of amiodarone in the treatment of cardiac dysrhythmias]. (nih.gov)
• Some investigators believe that breastfeeding can be undertaken during maternal amiodarone use with periodic monitoring of infant cardiac and thyroid function status,[ 5 , 6 ] especially if only a single dose of amiodarone is given. (nih.gov)
• BACKGROUND: Amiodarone and lidocaine have not been shown to have a clear survival benefit compared to placebo for out-of-hospital cardiac arrest (OHCA). (nih.gov)
• Subsequent studies have questioned the utility of amiodarone in cardiac arrest from the perspective of improving survival to hospital discharge or survival with a good neurological outcome. (rebelem.com)

Pulmonary3

• Amiodarone hydrochloride can cause pulmonary toxicity (hypersensitivity pneumonitis or interstitial/alveolar pneumonitis) that has resulted in clinically manifest disease at rates as high as 17% in some series of patients. (nih.gov)
• Obtain a baseline chest X-ray and pulmonary-function tests, including diffusion capacity, when amiodarone hydrochloride therapy is initiated. (nih.gov)
• For some time, the FDA was reluctant to approve amiodarone because of its link to serious pulmonary side effects. (dangerousdrugs.com)

Metabolite2

• Breastmilk and infant serum levels of amiodarone and its active metabolite are somewhat unpredictable, but can be high during breastfeeding. (nih.gov)
• Even if the drug were discontinued at birth, the mother would continue to excrete amiodarone and its metabolite (and possibly large amounts of iodine) into breastmilk for days to weeks. (nih.gov)

Medicines1

• The Committee for the Safety of Medicines has only two entries for amiodarone extravasation injury, yet almost every consultant seems to remember a patient who has had their arm amputated following extravasation of amiodarone. (bmj.com)

Shock-refractory1

• According to the advanced cardiovascular life support (ACLS) algorithm, amiodarone is still the recommended first-line medication for shock refractory VF/VT. (rebelem.com)

Antiarrhythmic effects2

• No data are available on the activity of DEA in humans, but in animals, it has significant electrophysiologic and antiarrhythmic effects generally similar to amiodarone itself. (nih.gov)
• Amiodarone may interact with thyroid nuclear receptors, but its antiarrhythmic effects are believed to be mediated by its action in blocking membrane ion channels via perturbation of the lipid environment in the membrane bilayer. (nih.gov)

Toxicity1

• The injury resembles alcoholic liver disease clinically and histologically, although serum ALT and AST are usually elevated to a similar degree in amiodarone toxicity in contrast to alcoholic liver injury. (nih.gov)

Tablet2

• Each amiodarone hydrochloride tablet intended for oral administration contains 200 mg of amiodarone hydrochloride. (nih.gov)
• Amiodarone comes as a tablet to take by mouth. (medlineplus.gov)

Hepatic1

• Intravenous amiodarone treatment is instituted, but at 12 hours after initiation of treatment, there is a significant increase in the level of hepatic transaminases. (zenodo.org)

Dose2

• The effects of food upon the bioavailability of amiodarone have been studied in 30 healthy subjects who received a single 600 mg dose immediately after consuming a high-fat meal and following an overnight fast. (nih.gov)
• Your doctor will probably start you on a high dose of amiodarone and gradually decrease your dose as the medication begins to work. (medlineplus.gov)

Body's2

• Amiodarone can cause a number of serious side effects pertaining to the body's major organs. (drugsdb.com)
• When mixed with amiodarone, MDMA can affect the body's ability to keep the correct temperature. (worldsbest.rehab)

Lidocaine4

• We sought to evaluate how timing from emergency medical services (EMS) arrival on scene to drug administration affects the efficacy of amiodarone and lidocaine compared to placebo. (nih.gov)
• METHOD: This is a secondary analysis of the 10-site, 55-EMS-agency double-blind randomized controlled amiodarone, lidocaine, or placebo in OHCA study. (nih.gov)
• We compared outcomes for amiodarone and lidocaine compared to placebo and adjust for potential confounders. (nih.gov)
• Evaluated effects of amiodarone compared with alternative treatments (lidocaine, nifekalant, or placebo) on the following outcomes: (1) ROSC (2) survival to hospital admission (3) survival to 24 hrs (4) survival to hospital discharge (5) neurological outcome. (rebelem.com)

Favorable2

• After we stopped the amiodarone administration, the evolution is favorable, with the remission of the cytolysis syndrome. (zenodo.org)
• This systematic review and meta-analysis demonstrates that while amiodarone significantly increased survival to hospital to admission compared with placebo or other antidysrhythmics for OHCA, it does not significantly improve favorable neurological outcome or survival to hospital discharge. (rebelem.com)

Tissues1

• Amiodarone is highly lipophilic and is concentrated in many tissues and cells, including hepatocytes in the liver. (nih.gov)

Allergic3

• Case report of amiodarone-associated allergic pneumonitis amidst the COVID-19 pandemic. (pneumotox.com)
• More serious side effects of amiodarone can indicate an allergic reaction. (drugsdb.com)
• Rapid weight loss and weight gain are associated with serious allergic reactions to amiodarone, so individuals experiencing large weight fluctuations in a very short period of time should contact their physician. (drugsdb.com)

CONCLUSIONS1

• CONCLUSIONS: The early administration of amiodarone, particularly within 8 min, is associated with greater survival to admission, survival to discharge, and functional survival compared to placebo in patients with an initial shockable rhythm. (nih.gov)

Thyroid function2

• Metabolism also releases 6 mg of free iodine for each 100 mg of amiodarone which can affect thyroid function. (nih.gov)
• This study provides data to reconsider the yield of regular testing of thyroid function to predict overt thyroid dysfunction in amiodarone treated patients. (bioscientifica.com)

Treatment5

• You will probably be hospitalized for one week or longer when you begin your treatment with amiodarone. (medlineplus.gov)
• Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amiodarone and each time you refill your prescription. (medlineplus.gov)
• There is an increased risk also when doctors prescribe amiodarone for off-label use, without informing the patient about the possible side effects, or that the FDA had not approved its treatment as safe and effective. (dangerousdrugs.com)
• While some of these side effects can manifest soon after beginning treatment, it is possible for them to appear months after a patient starts taking amiodarone (and even months after treatment ends), so it important for individuals to closely monitor themselves after discontinuing use of the drug. (drugsdb.com)
• We discuss a case of an eight-year-old child with Ebstein's anomaly who presented with supraventricular tachycardia and was effectively treated with amiodarone after initial treatment with adenosine failed to reduce the heart rate . (bvsalud.org)

Dosage1

• The average milk amiodarone concentration was 3.5 mg/L. The authors calculated that her infant would have received an average of 18% and a maximum of 26% of the maternal weight-adjusted dosage of amiodarone. (nih.gov)

Accumulation3

• Amiodarone has a very large but variable volume of distribution, averaging about 60 L/kg, because of extensive accumulation in various sites, especially adipose tissue and highly perfused organs, such as the liver, lung, and spleen. (nih.gov)
• The development of maximal ventricular Class III effects after oral amiodarone administration in humans correlates more closely with DEA accumulation over time than with amiodarone accumulation. (nih.gov)
• Often these elevations resolve despite continuation of amiodarone, and liver biopsy may reveal minimal changes, or accumulation of granular material in macrophages without other evidence of injury. (nih.gov)

Dysfunction1

• As the onset of AIT and AIH may be unpredictable, the value of long-term regular monitoring of amiodarone treated patients for thyroid dysfunction is still uncertain. (bioscientifica.com)

Patients6

• After oral dosing, however, amiodarone produces no significant change in left ventricular ejection fraction (LVEF), even in patients with depressed LVEF. (nih.gov)
• Patients taking amiodarone are recommended to have ALT and AST values taken at baseline and then every six months, and to discontinue therapy if levels are persistently greater than twice the upper limit of the normal range. (nih.gov)
• Clinically apparent liver disease arises in up to 1% of amiodarone treated patients annually. (nih.gov)
• This case highlights the need for careful monitoring of patients receiving intravenous amiodarone to identify any potential for hepatotoxicity. (zenodo.org)
• We included 303 patients treated with amiodarone between 1984 and 2007. (bioscientifica.com)
• In 2004, Amiodarone was prescribed to 2.3 million patients, and 82 percent of these were not for approved conditions. (dangerousdrugs.com)

Rhythms1

• Amiodarone is a medicine which prevents abnormal heart rhythms. (nih.gov)

Epididymitis1

• However, in some cases amiodarone has been found to trigger epididymitis in men, which is an inflammation of the scrotal tissue. (drugsdb.com)

Side effects2

• Generally, men and women experience similar common side effects of amiodarone. (drugsdb.com)
• Amiodarone is associated with a wide range of side effects. (verywellhealth.com)

Significantly1

• Amiodarone significantly improves survival to hospital admission. (rebelem.com)

Placebo1

• However, amiodarone does not improve survival to discharge or neurological outcomes compared to placebo or other antidysrhythmics. (rebelem.com)

Slowly1

• Following oral administration in man, amiodarone is slowly and variably absorbed. (nih.gov)

Situations1

• Amiodarone is for use only in life-threatening situations. (dangerousdrugs.com)

Concentration1

• The area under the plasma concentration-time curve (AUC) and the peak plasma concentration (C max ) of amiodarone increased by 2.3 (range 1.7 to 3.6) and 3.8 (range 2.7 to 4.4) times, respectively, in the presence of food. (nih.gov)

Affect1

• Amiodarone is a substrate for CYP3A and CYP2C8, so inhibitors and inducers affect amiodarone exposure. (nih.gov)

Survival1

• These recommendations stem from two hallmark studies which demonstrated improved ROSC and survival rates to admission after amiodarone was administered ( Dorian 2002 , Kudenchuk 1999 ). (rebelem.com)

Interval1

• amiodarone and trimethoprim both increase QTc interval. (medscape.com)

Effects2

• Little conclusive evidence has been drawn regarding the effects of amiodarone during the gestational stage. (drugsdb.com)
• MDMA on its own and even without amiodarone can have many of the same effects as other stimulants like cocaine and amphetamines. (worldsbest.rehab)

Abnormal1

• Additionally, some men have also reported gynecomastia (an abnormal development of mammary glands) as a result of taking amiodarone. (drugsdb.com)

Peripheral1

• Surely this is a case of the dangers of peripheral amiodarone being exagerated? (bmj.com)

Heart1

• In addition to pregnant women, amiodarone is not recommended for those who have been diagnosed with clogged arteries, abnormally low heart rate, a preexisting respiratory condition, or those who have been fitted with a pacemaker. (drugsdb.com)