AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
Aminosalicylic AcidsMesalamineAminosalicylic AcidSulfapyridineSulfasalazineAnti-Inflammatory Agents, Non-SteroidalColitis, UlcerativeEnemaPhenylhydrazinesInflammatory Bowel DiseasesProctitisDelayed-Action PreparationsSuppositoriesAzathioprineGastrointestinal Agents6-MercaptopurineSulfanilamidesColonAdministration, RectalSalicylatesTablets, Enteric-CoatedAmyloseCrohn DiseaseColitisAnti-Inflammatory AgentsTabletsAdministration, OralIntestinal AbsorptionAnti-Ulcer AgentsPrednisoloneChemistry, PharmaceuticalAdrenal Cortex HormonesDouble-Blind MethodPatient ComplianceIntestinesIleumDose-Response Relationship, DrugElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternetPatents as TopicIntermediate Filament ProteinsManganese PoisoningAntitubercular AgentsAnacardiumAllergy and ImmunologyKidney PelvisAnal Canal
Aminosalicylic Acids
A group of 2-hydroxybenzoic acids that can be substituted by amino groups at any of the 3-, 4-, 5-, or 6-positions.
Mesalamine
An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
Aminosalicylic Acid
An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.
Sulfapyridine
Antibacterial, potentially toxic, used to treat certain skin diseases.
Sulfasalazine
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Colitis, Ulcerative
Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
Enema
A solution or compound that is introduced into the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.
Phenylhydrazines
Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)
Inflammatory Bowel Diseases
Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.
Proctitis
INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).
Delayed-Action Preparations
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Suppositories
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Azathioprine
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Gastrointestinal Agents
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
6-Mercaptopurine
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Sulfanilamides
Compounds based on 4-aminobenzenesulfonamide. The '-anil-' part of the name refers to aniline.
Colon
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Administration, Rectal
The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.
Salicylates
The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
Tablets, Enteric-Coated
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Amylose
An unbranched glucan in starch.
Crohn Disease
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION.
Tablets
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Intestinal Absorption
Uptake of substances through the lining of the INTESTINES.
Anti-Ulcer Agents
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Prednisolone
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Chemistry, Pharmaceutical
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Adrenal Cortex Hormones
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Patient Compliance
Voluntary cooperation of the patient in following a prescribed regimen.
Intestines
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
Ileum
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Electronic Mail
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Food Dispensers, Automatic
Mechanical food dispensing machines.
Editorial Policies
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
Authorship
The profession of writing. Also the identity of the writer as the creator of a literary production.
Periodicals as Topic
A publication issued at stated, more or less regular, intervals.
Postal Service
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
Internet
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Patents as Topic
Exclusive legal rights or privileges applied to inventions, plants, etc.
Intermediate Filament Proteins
Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.
Manganese Poisoning
Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
Antitubercular Agents
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
Anacardium
A plant genus of the family ANACARDIACEAE. This is the source of the familiar cashew nuts, which are heat treated to remove the irritant toxin. Cashew nut shell liquid (frequently abbreviated as CNSL) is a major source of alkenyl phenolic compounds, especially ANACARDIC ACIDS, cardol, and cardanol.
Allergy and Immunology
A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
Kidney Pelvis
The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.
Anal Canal
The terminal segment of the LARGE INTESTINE, beginning from the ampulla of the RECTUM and ending at the anus.

The systemic load and efficient delivery of active 5-aminosalicylic acid in patients with ulcerative colitis on treatment with olsalazine or mesalazine. (1/215)

BACKGROUND: There have been reports of nephrotoxic reactions in patients with ulcerative colitis treated with 5-aminosalicylic acid (5-ASA) preparations. AIM: To compare the efficacy in delivery of active 5-ASA to the colon and the systemic load as the basis for potential long-term toxicity during treatment with olsalazine or mesalazine in patients with ulcerative colitis in remission. PATIENTS AND METHODS: Fifteen patients with ulcerative colitis were treated with olsalazine or mesalazine, each for 7 days in an open, randomized, crossover design study. 5-ASA and acetyl-5-ASA (Ac-5-ASA) in plasma and urine were measured by high performance liquid chromatography. RESULTS: The plasma concentration of 5-ASA was 1.2 +/- 0.1 micromol/L (mean +/- S.E.M.) for olsalazine and 8.0 +/- 1.9 micromol/L for mesalazine, while the plasma concentration of Ac-5-ASA was 2.8 +/- 0.2 micromol/L for olsalazine and 10.8 +/- 1.6 micromol/L for mesalazine. The amount of 5-ASA excreted in the urine was 68 +/- 30 micromol/24 h for olsalazine and 593 +/- 164 micromol/24 h for mesalazine. The amount of Ac-5-ASA in the urine was 1260 +/- 102 micromol/24 h for olsalazine and 3223 +/- 229 micromol/24 h for mesalazine. The urinary recovery of total 5-ASA plus Ac-5-ASA (as a percentage of the given dose) was 23 +/- 2.1% for olsalazine and 39 +/- 3.6% for mesalazine. The ratio between the plasma concentrations of mesalazine and olsalazine differed significantly both for 5-ASA (5.1) and Ac-5-ASA (3.6); for 5-ASA (9. 9) and Ac-5-ASA (2.6) in urine, and for the urinary recovery of total 5-ASA plus Ac-5-ASA (1.7). Moreover, in the mesalazine group there was a large variation in the individual plasma concentrations of 5-ASA and Ac-5-ASA, with maximal values 5-6-fold higher than that in the olsalazine group. CONCLUSION: The systemic load of active 5-ASA is significantly higher for mesalazine than for olsalazine, when based on the dosages given and when calculated on an equimolar basis. Some of the patients in the mesalazine group showed unexpected high levels of plasma and urinary 5-ASA concentrations, a finding which may have long-term safety implications.  (+info)

Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies. (2/215)

BACKGROUND: The therapeutic efficacy of 5-aminosalicylic acid in inflammatory bowel disease may be related to its antioxidant properties. AIM: To compare in vitro the antioxidant effects of conventional drugs (5-aminosalicylic acid, corticosteroids, metronidazole), with new aminosalicylates (4-aminosalicylic acid, balsalazide) and other potential therapies (ascorbate, N-acetylcysteine, glutathione, verapamil). METHODS: Compounds were assessed for efficacy in reducing the in vitro production of reactive oxygen species by cell-free systems (using xanthine/xanthine oxidase, with or without myeloperoxidase) and by colorectal biopsies from patients with ulcerative colitis using luminol-amplified chemiluminescence. RESULTS: 5-aminosalicylic acid and balsalazide were more potent antioxidants than 4-aminosalicylic acid or N-acetyl-5-aminosalicylic acid in cell-free systems. 5-aminosalicylic acid (20 mM) and balsalazide (20 mM) inhibited rectal biopsy chemiluminescence by 93% and 100%, respectively, compared with only 59% inhibition by 4-aminosalicylic acid (20 mM). Hydrocortisone, metronidazole and verapamil had no significant effect on chemiluminescence in any system. Ascorbate (20 mM) inhibited chemiluminescence by 100% in cell-free systems and by 60% in rectal biopsies. N-acetyl cysteine (10 mM), and both oxidized and reduced glutathione (10 mM), completely inhibited chemiluminescence in cell-free systems, but not with rectal biopsies. CONCLUSIONS: The antioxidant effects of compounds varies between cell-free systems and inflamed colorectal biopsies. The effect of drugs on the chemiluminescence produced by these two assay systems is useful for screening potentially new antioxidant treatments for inflammatory bowel disease. Ascorbate seems worth further study as a novel therapy.  (+info)

Review article: the efficacy of infliximab in Crohn's disease--healing of fistulae. (3/215)

In the management of fistulae, the current therapeutic approach is the use of a combination of antibiotics and/or a combination of immunomodulatory agents. However, clinicians treating patients with fistulae, particularly those with fistulizing Crohn's disease, have little data from controlled clinical trials of these pharmacologic agents or regimens to substantiate their use in treating this complication. Therapy with the anti-tumour necrosis factor-alpha antibody, infliximab, has shown promise in treating patients with Crohn's disease and those with the disease complicated by fistulae. A recent clinical trial was designed specifically to evaluate infliximab in the treatment of fistulizing Crohn's disease. Study results demonstrated infliximab to be the first therapeutic agent to show statistical efficacy in fistulae closure in a placebo-controlled trial. Therapy with the chimeric monoclonal antibody was characterized by a rapid onset of closure and a lasting benefit of action. Two patient cases from the clinical trial are presented to exemplify the dramatic effectiveness of this novel therapeutic approach in modulating the immune response of patients with this debilitating complication of Crohn's disease.  (+info)

Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat. (4/215)

The present study was undertaken to investigate the intestinal anti-inflammatory effects of UR-12746 on the acute and chronic stages of a trinitrobenzene sulphonic acid (TNBS) experimental model of inflammatory bowel disease (IBD) in the rat. UR-12746 is a novel, locally-acting compound which combines, through an azo bond, 5-aminosalicylic (5-ASA) and UR-12715, a potent platelet activating factor (PAF)-antagonist. UR-12746 oral pretreatment of colitic rats (50 and 100 mg kg(-1)) reduced acute colonic damage when evaluated 2 days after colonic insult. Postreatment for 4 weeks with UR-12746 (50 and 100 mg kg(-1)) resulted in a faster recovery of the damaged colonic mucosa, which was macroscopically significant from the third week. The intestinal anti-inflammatory effect of UR-12746 was associated with a decrease in leukocyte infiltration in the colonic mucosa, which was evidenced both biochemically, by a reduction in myeloperoxidase activity, and histologically, by a lower leukocyte count after morphometric analysis. This effect was higher than that seen with sulphasalazine, when assayed at the same doses and in the same experimental conditions. Several mechanisms can be involved in the beneficial effects showed by UR-12746: inhibition of leukotriene B(4) synthesis in the inflamed colon, improvement of the altered colonic oxidative status, and reduction of colonic interleukin-1beta production. The results suggest that the intestinal anti-inflammatory activity of UR-12746 can be attributed to the additive effects exerted by 5-ASA and UR-12715, the PAF antagonist compound, that are released in the colonic lumen after reduction of the azo bond by the intestinal bacteria.  (+info)

Minimal renal dysfunction in inflammatory bowel disease is related to disease activity but not to 5-ASA use. (5/215)

BACKGROUND: Conflicting data exist about proteinuria in inflammatory bowel diseases. It is still unclear whether the occurrence of proteinuria in inflammatory bowel disease patients is an extra-intestinal manifestation of disease or the result of adverse effects to medication, especially to aminosalicylates (ASA). METHODS: A total of 95 patients (51 with Crohn's disease and 44 with ulcerative colitis) were enrolled in the study. Disease activity was assessed by Crohn's Disease Activity Index (CDAI) or the Truelove index, respectively. Urine was collected over 24 h and protein excretion of specific marker proteins for tubular (alpha 1-microglobulin-alpha 1-MG) and glomerular (albumin-Alb, Immunoglobulin G-IgG) dysfunction was measured using a highly sensitive immunoluminometric assay. RESULTS: Out of 51 Crohn's disease patients, 20 showed elevated urinary alpha 1-MG. The amount of alpha 1-MGuria was strongly correlated to the CDAI (r=0.6, P < 0.001). Only four Crohn's disease patients showed slightly elevated values for glomerular proteins in urine. Similar results were obtained for ulcerative colitis: whereas only two ulcerative colitis patients showed albuminuria, tubular proteinuria was detected in 28 out of 44 ulcerative colitis patients. Proteinuria was strongly dependent on disease activity (P < 0.01) but was not related to ASA treatment. CONCLUSIONS: Proteinuria of tubular marker proteins occurs in the majority of inflammatory bowel disease patients and is related to disease activity rather than to ASA treatment. Tubular proteinuria seems to reflect a renal extra-intestinal manifestation of inflammatory bowel disease and may serve as a new relevant marker of disease activity.  (+info)

NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines. (6/215)

The activation of a self-amplifying cascade of caspases, of which caspase-8 is the apical protease, mediates Fas-, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-, and TNF-alpha-induced apoptosis in colon cell lines. Nitric oxide (NO) protects from apoptosis induced by Fas and TNF-alpha. We examined whether NCX-456, an NO-releasing derivative of mesalamine, protects colon epithelial cells from cytokine-induced apoptosis. Caco-2 and HT-29 cell lines express death factor receptors and are driven to apoptosis in response to incubation with Fas-agonistic antibody, TNF-alpha/interferon-gamma, and TRAIL. The two novel observations reported here are that 1) cotreatment of cells with NCX-456, but not mesalamine, resulted in concentration-dependent protection against death factor-induced apoptosis and inhibition of caspase activity, and 2) exposure to dithiothreitol, an agent that effectively removes NO from thiol groups, resulted in a 70% recovery of caspase activity, which is consistent with S-nitrosation as a major mechanism for caspase inactivation. These data suggest that caspase S-nitrosation represents a mechanism for protection of colonic mucosal epithelial cells from death factor-induced death.  (+info)

Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study. (7/215)

BACKGROUND AND AIMS: The benefit of 5-aminosalicylic acid therapy for maintenance of remission in Crohn's disease is controversial. The primary aim of this study was to evaluate the prophylactic properties of olsalazine in comparison with placebo for maintenance of remission in quiescent Crohn's colitis and/or ileocolitis. METHODS: In this randomised, double blind, parallel group study of olsalazine versus placebo, 328 patients with quiescent Crohn's colitis and/or ileocolitis were recruited. Treatment consisted of olsalazine 2.0 g daily or placebo for 52 weeks. The primary end point of efficacy was relapse, as defined by the Crohn's disease activity index (CDAI) and by clinical relapse. Laboratory and clinical disease activity indicators were also measured. Safety analysis consisted of documentation of adverse events and laboratory values. RESULTS: No differences in the frequency of termination due to relapse or time to termination due to relapse were noted between the two treatment groups (olsalazine 48.5% v placebo 45%) for either colitis or ileocolitis. The failure rate, defined as not completing the study, was significantly higher in olsalazine treated patients compared with placebo treated patients for the overall population (colitis and/or ileocolitis: olsalazine 65.4% v 53.9%; p=0.038). Similar failure rates were seen for patients with colitis. A significantly higher percentage of olsalazine treated patients experienced adverse gastrointestinal events. Drug attributed adverse events were reported more frequently in the olsalazine treated group with gastrointestinal symptoms being causally related to olsalazine treatment (olsalazine 40.7% v placebo 26.9%; p=0.010). Back pain was reported significantly more often by the placebo treated group. However, serious medical events did not differ between the two groups. Adverse events led to more early withdrawals in the olsalazine treated group than in the placebo treated group; thus average time in the study for patients in the olsalazine treatment group was significantly shorter than that of patients in the placebo group. CONCLUSIONS: Patients treated with olsalazine were more likely to terminate their participation in the trial than those taking placebo. This difference was not related to relapse of disease, as measured by CDAI and clinical measures, but rather was due to the development of intolerable adverse medical events of a non-serious nature related to the gastrointestinal tract. The gastrointestinal related events in the olsalazine treated group may be due to the difference in gastrointestinal status at baseline which favoured the placebo treatment group.  (+info)

Review article: balsalazide therapy in ulcerative colitis. (8/215)

Balsalazide is a 5-aminosalicylic acid (mesalazine) pro-drug which has an inert carrier molecule instead of the sulfapyridine moiety of sulfasalazine. It is designed to deliver 5-aminosalicylic acid to the colonic mucosa without the sulfapyridine-associated side-effects encountered with sulfasalazine. Several studies have confirmed the efficacy and patient tolerance of balsalazide. When compared to mesalazine at equivalent doses, it induced symptomatic and complete remission of acute ulcerative colitis in a greater proportion of patients. In particular, patients with resistant left-sided disease were shown to have a higher probability of achieving remission. Balsalazide was beneficial in patients with troublesome nocturnal symptoms. It has a similar efficacy in maintaining remission when compared to sulfasalazine and mesalazine. The advantage of balsalazide over other 5-aminosalicylic acid compounds is its superior patient tolerability with minimal side-effects.  (+info)

Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for...Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for...
Title:Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for Inflammatory Bowel Disease: A Colon-Targeted Approach. VOLUME: 12 ISSUE: 5. Author(s):Dhaneshwar Suneela, Vadnerkar Gaurav and Rai Himanshu. Affiliation:Department of Pharmaceutical Chemistry, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune-411038, Maharashtra, India.. Keywords:4-Aminosalicylic acid, 5-Aminosalicylic acid, azo prodrug, colon-targeting, inflammatory bowel disease, sulfasalazine.. Abstract:Novel carrier-linked azo prodrugs of 4 and 5-aminosalicylic acids (4-ASA and 5-ASA respectively) using the same drugs as carriers in different permutations and combinations were designed for targeting colon affected with inflammatory bowel disease (IBD). Improved hydrophilic nature of the prodrugs assisted in minimizing their absorption in upper GIT and efficient delivery of the active drugs to colon as evidenced from their stability in aqueous ...
http://www.eurekaselect.com/114960/article
Controlled trial comparing olsalazine and sulphasalazine for maintenance treatment of ulcerative colitis. - Nuffield Department...Controlled trial comparing olsalazine and sulphasalazine for maintenance treatment of ulcerative colitis. - Nuffield Department...
Olsalazine and sulphasalazine were compared in a double-blind, double-dummy trial in the prevention of relapse of ulcerative colitis over 6 months. The majority were taking sulphasalazine. They were randomized to receive either olsalazine, 500 mg b.d., or sulphasalazine, 1 g b.d. Of 82 patients, 16 relapsed on olsalazine compared with 10 of 82 on sulphasalazine. This difference was not statistically significant (p = 0.16). Twenty-one patients reported adverse events in the olsalazine group, of whom 16 were withdrawn, while 20 patients reported adverse events in the sulphasalazine group, with 9 of them being withdrawn. The differences were not statistically significant. No major haematological or biochemical abnormalities occurred. Thus, olsalazine is similar to sulphasalazine for the prevention of relapse of ulcerative colitis.
https://www.ndm.ox.ac.uk/publications/135373
Global 5-Aminosalicylic Acid Market Research Report 2018 : ReportsnReportsGlobal 5-Aminosalicylic Acid Market Research Report 2018 : ReportsnReports
[123 Pages Report] Check for Discount on Global 5-Aminosalicylic Acid Market Research Report 2018 report by QYResearch Group. In this report, the global 5-Aminosalicylic Acid market is...
http://www.reportsnreports.com/reports/1285122-global-5-aminosalicylic-acid-market-research-report-2018.html
Suppliers of 2-Chloroacetonitrile, 5-Amino Salicylic Acid, 3-Amino Salicylic Acid, 5-Chloro Salicylic in Ankleshwar, - IndiaSuppliers of 2-Chloroacetonitrile, 5-Amino Salicylic Acid, 3-Amino Salicylic Acid, 5-Chloro Salicylic in Ankleshwar, - India
Manufacturers and Suppliers of 2-Chloroacetonitrile, 5-Amino Salicylic Acid, 3-Amino Salicylic Acid, 5-Chloro Salicylic Acid, Ferrous Fumarate, Cetirizine Dihydrochloride, Ascorbic Palmitate, in Ankleshwar, - India
https://www.needsinfo.com/company/crystal-chemie-pvt.-ltd.
METHOD OF TREATING INFLAMMATORY BOWEL DISEASE - Patent applicationMETHOD OF TREATING INFLAMMATORY BOWEL DISEASE - Patent application
0076]There has been surprisingly little work involving 4-ASA in IBD, particularly in the United States. However, in 1984, a 4-aminosalicylic acid rectal preparation was shown to have equal activity to the 5-ASA preparation (Campieri A, Lanfranchi G A, Bertoni F, Brignola C, Bazzocchi G, Minguzzi M R, and Labo G. A Double-Blind Clinical Trial to Compare the Effects of 4-Aminosalicylic Acid to 5-Aminosalicylic Acid in Topical Treatment of Ulcerative Colitis. Digestion. 1984; 29:204-208). 4-ASA enemas were shown to be more effective in inducing clinical and sigmoidoscopic improvement than placebo at either 1 or 2 gram doses for distal ulcerative colitis (Selby W S, Bennett M K, Jewell D P. Topical treatment of distal ulcerative colitis with 4-amino-salicylic acid enemas. Digestion 1984; 29:231-234). Subsequently, a 2 gram nightly 4-ASA retention enema was shown to result in significant improvement in clinical, sigmoidoscopic and histologic variables after 8 weeks in active left-sided ulcerative ...
http://www.patentsencyclopedia.com/app/20100136125
Paser (Aminosalicylic Acid): Side Effects, Interactions, Warning, Dosage & UsesPaser (Aminosalicylic Acid): Side Effects, Interactions, Warning, Dosage & Uses
Learn about Paser (Aminosalicylic Acid) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
https://www.rxlist.com/paser-drug.htm
Aminosalicylic Acid: Indications, Side Effects, Warnings - Drugs.comAminosalicylic Acid: Indications, Side Effects, Warnings - Drugs.com
Easy to read patient leaflet for Aminosalicylic Acid. Includes indications, proper use, special instructions, precautions, and possible side effects.
https://www.drugs.com/cdi/aminosalicylic-acid.html
AMINO SALICYLIC ACID manufacturing companiesAMINO SALICYLIC ACID manufacturing companies
Listing your company for AMINO SALICYLIC ACID allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo!, MSN etc ...
http://www.poulvet.com/bulk_drugs/product_companies_india.php?sclid=1683&prefix=V
Aminosalicylates - GPI MEDICAL MARIJUANA CLINIC & RESOURCESAminosalicylates - GPI MEDICAL MARIJUANA CLINIC & RESOURCES
Rationale:The major metabolite of mesalamine (5-aminosalicylic acid) is N-acetyl-5- aminosalicylic acid. Its formation is brought about by N-acetyltransferase activity in the liver and intestinal mucosa. No investigations have been performed between LIALDA and other drugs. However based on its metabolic profile mesalamine is not expected to interact with cannabis. ...
http://www.gpimedical.com/aminosalicylates.html
Sodium 4-aminosalicylate dihydrate 6018-19-5 H-NMR | C-NMR Spectral Analysis NMR SpectrumSodium 4-aminosalicylate dihydrate 6018-19-5 H-NMR | C-NMR Spectral Analysis NMR Spectrum
Sodium 4-aminosalicylate dihydrate 6018-19-5 NMR spectrum, Sodium 4-aminosalicylate dihydrate H-NMR spectral analysis, Sodium 4-aminosalicylate dihydrate C-NMR spectral analysis ect.
http://www.molbase.com/en/hnmr_6018-19-5-moldata-22293.html
balsalazide | Cignabalsalazide | Cigna
The Colazal brand of balsalazide is used to treat mild to moderate active ulcerative colitis in adults and children who are at least 5 years old. The Giazo brand of balsalazide is used to treat mild to moderate active ulcerative colitis in men who are at least 18 years old. Balsalazide may also be used for purposes not...
https://www.cigna.com/individuals-families/health-wellness/hw/medications/balsalazide-d04700a1
Review: 5-aminosalicylic acid is more effective than placebo but not sulfasalazine for ulcerative colitis | Annals of Internal...Review: 5-aminosalicylic acid is more effective than placebo but not sulfasalazine for ulcerative colitis | Annals of Internal...
Randomized controlled trials were included if they compared oral 5-ASA with sulfasalazine or placebo for a minimum of 4 weeks for acute therapy and 6 months for maintenance therapy in patients with mild-to-moderate ulcerative colitis. Of 59 trials identified, 27 met the inclusion criteria: 16 for active treatment and 11 for remission maintenance ...
http://annals.org/aim/article-abstract/2534822/review-5-aminosalicylic-acid-more-effective-than-placebo-sulfasalazine-ulcerative
PDF] 5-Aminosalicylic acid and colorectal carcinogenesis Download EbookPDF] 5-Aminosalicylic acid and colorectal carcinogenesis Download Ebook
Inflammatory bowel diseases are associated with increased risk of developing colitis‐associated colorectal cancer (CAC). Epidemiological data show that the consumption of ω‐3Cited by:
https://byzewivyzufatewyn.desi.pw/5-aminosalicylic-acid-and-colorectal-carcinogenesis-book-39583dl.php
Phase III Study of MLN0002 (300 mg) in Treatment of Crohn's Disease - Full Text View - ClinicalTrials.govPhase III Study of MLN0002 (300 mg) in Treatment of Crohn's Disease - Full Text View - ClinicalTrials.gov
Patients with an evidence of or suspected abdominal abscess 2. Patients with a history of subtotal or total colectomy 3. Patients who have had a resection of the small intestine in at least 3 locations or have a diagnosis of short bowel syndrome 4. Patients with ileostomy,colostomy,or internal fistula, or severe intestinal stenosis 5. Patients who started 5-aminosalicylic acid oral drug or probiotics treatment, antimicrobials to treat Crohns disease, or 30 mg/day or less of oral corticosteroids within 13 days before initiation of study drug administration. If these drugs were used within 14 days before initiation of study drug administration, the dosage must have been changed or their use discontinued within 13 days before the initiation of study drug administration 6. Patients who have received 5-aminosalicylic acid or corticosteroid enemas/suppositories, intravenous corticosteroid injections, or more than 30 mg/day of oral corticosteroids, medications for diarrhea-predominant irritable bowel ...
https://www.clinicaltrials.gov/ct2/show/NCT02038920?term=NCT02038920&rank=1
High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease - Full Text View...High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease - Full Text View...
Crohns disease involving predominantly the ileum and/or cecum. The diagnosis must have been established by radiography, endoscopy and/or biopsy (at least 2 of the 3 modalities) with at least one confirmatory test having been performed no more than 36 months before entry. The diagnosis must have been confirmed by at least one gastroenterologist ...
https://clinicaltrials.gov/show/NCT00417690
Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with...Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with...
Patients with UC chronically consume 5-ASA to reduce the frequency and severity of clinical recurrence. In spite of treatment, the clinical course of the disease is extremely variable, ranging from periods of prolonged remission to frequent episodes of relapse. Since one possible explanation for the high recurrence rate could be a poor response to treatment, a higher dosage of 5-ASA has been used to provide additional therapeutic benefit to patients. Clinical trials, however, failed to demonstrate a clear cut dose-response relationship for 5-ASA.12-16 26 27 We have demonstrated an inverse relationship between mucosal concentrations of 5-ASA and UC disease activity-that is, in the same part of the intestinal tract, the higher the drug concentration, the lower the endoscopic and histological scores. Moreover, mucosal concentrations of 5-ASA were inversely correlated with mucosal levels of sIL-2R, a marker of mucosal inflammation.. In vitro studies have demonstrated that 5-ASA inhibits the activity ...
http://gut.bmj.com/content/47/3/410
5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer | Gut5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer | Gut
Methods The influence of 5-ASA on mTOR signalling was examined in a panel of colorectal cancer cell lines. The effects of 5-ASA on the pathways that control mTOR activity were studied in detail in two different colorectal cancer cell lines, using western blot, siRNA, a phospholipase D (PLD) activity assay, proliferation assays and cell cycle analysis. The phosphorylation status of mTOR and its downstream target, ribosomal protein S6, was studied in colorectal cancers before and after topical 5-ASA treatment.. ...
https://gut.bmj.com/content/61/12/1708
DL-Adrenalin|L(-)-Epinephrine|5-Azacytidine|N4-Acetylcytosine|5-Aminosalicylic acid|--Xinxiang TianfDL-Adrenalin|L(-)-Epinephrine|5-Azacytidine|N4-Acetylcytosine|5-Aminosalicylic acid|--Xinxiang Tianf
Xinxiang Tianfeng Fine Chemical Co., Ltd. engaging in the research, development, production and marketing of fine chemical products, pharmaceutical raw materials and its intermediate. The cooperation project also includes synthesis of compounds, and improvement of compound production technique. Tianfeng owns a set of perfect inspection equipment and test equipment, and the production system is in compliance with GMP Quality Management Model.
http://www.artsiteweb.com/job_en.html
DL-Adrenalin|L(-)-Epinephrine|5-Azacytidine|N4-Acetylcytosine|5-Aminosalicylic acid|--Xinxiang TianfDL-Adrenalin|L(-)-Epinephrine|5-Azacytidine|N4-Acetylcytosine|5-Aminosalicylic acid|--Xinxiang Tianf
Xinxiang Tianfeng Fine Chemical Co., Ltd. engaging in the research, development, production and marketing of fine chemical products, pharmaceutical raw materials and its intermediate. The cooperation project also includes synthesis of compounds, and improvement of compound production technique. Tianfeng owns a set of perfect inspection equipment and test equipment, and the production system is in compliance with GMP Quality Management Model.
http://www.artsiteweb.com/about_2_en.html
Patent US6380386 - Substituted aminosalicylic acid amides with fungicidal effect and ... - Google PatentsPatent US6380386 - Substituted aminosalicylic acid amides with fungicidal effect and ... - Google Patents
The invention relates to novel substituted aminosalicylamides, to a plurality of processes for their preparation and to their use as fungicides, and also to novel intermediates and to a plurality of processes for their preparation.
http://www.google.com/patents/US6380386?dq=5,867,764
Calcium (aminosalicylate de) - Drugs.comCalcium (aminosalicylate de) - Drugs.com
Calcium (aminosalicylate de) is a medicine available in a number of countries worldwide. A list of US medications equivalent to Calcium (aminosalicylate de) is available on the Drugs.com website.
https://www.drugs.com/international/calcium-aminosalicylate-de.html
Dipentum (olsalazine) - Doctor SolveDipentum (olsalazine) - Doctor Solve
Dipentum (olsalazine) is used to treat ulcerative colitis (also known as Inflammatory bowel disease). Learn More About Dipentun Here!
https://www.doctorsolve.com/blog/dipentum-olsalazine/
my colitis journeymy colitis journey
aminosalicylic acid (5-ASA) - a type of drug used to reduce inflammation in inflammatory bowel disease including balsalazide, mesalazine, oslalazine and sulphasalazine anaemia - reduced number of red blood cells which carry oxygen around the body often causing fatigue due to poor intake or absorption of vitamins and iron anal fissure - a crack or…
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Dipentum (Olsalazine) - United Pharmacies (UK)Dipentum (Olsalazine) - United Pharmacies (UK)
Dipentum (Olsalazine) is given to patients suffering from ulcerative colitis. This medication is considered effective at treating the symptoms this condition can cause, such as inflammation of the bowel, pain in the stomach, diarrhoea, bleeding of the rectum and other tissue damage.
https://www.unitedpharmacies-uk.md/Dipentum-Olsalazine-250mg-100-Capsules-p-849.html
olsalazine, Dipentum for UC Side Effects, Uses & Dosingolsalazine, Dipentum for UC Side Effects, Uses & Dosing
Information about the ulcerative colitis drug olsalazine (Dipentum), including side effects, dosage, drug interactions, and pregnancy safety.
https://www.medicinenet.com/olsalazine/article.htm
Mesasal - Uses, Side Effects, Interactions - Canada.comMesasal - Uses, Side Effects, Interactions - Canada.com
Mesasal: 5-aminosalicylic acid (5-ASA or mesalamine) belongs to the group of medications known as anti-inflammatories. It is used to treat mild to moderate ulcerative colitis and mild to moderate Crohns disease. 5-ASA acts by reducing inflammation in the bowel.
http://bodyandhealth.canada.com/drug/getdrug/mesasal
Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism<...Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism<...
TY - JOUR. T1 - Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism. AU - De Boer, Nanne K.H.. AU - Wong, Dennis R.. AU - Jharap, Bindia. AU - De Graaf, Peer. AU - Hooymans, Piet M.. AU - Mulder, Chris J.J.. AU - Rijmen, Frank. AU - Engels, Leopold G.J.B.. AU - Van Bodegraven, Adriaan A.. PY - 2007/12/1. Y1 - 2007/12/1. N2 - INTRODUCTION: Studies indicated that 5-aminosalicylates (5-ASA) may influence the metabolism of thiopurines; however, conclusions were restricted as a result of number of patients or study design. AIM: To determine the influence of 5-ASA on thiopurine metabolism, we performed a prospective multicenter pharmacokinetic interaction study of two different 5-ASA dosages (2 g daily followed by 4 g daily) in 26 inflammatory bowel disease (IBD) patients during steady-state AZA or 6-MP therapy. RESULTS: The 4-wk coadministration of 2 g 5-ASA daily, followed by a 4-wk period of 4 g 5-ASA daily, led to a statistical significant increase of 40% (absolute 84 pmol/8 × ...
https://research.vumc.nl/en/publications/dose-dependent-influence-of-5-aminosalicylates-on-thiopurine-meta
poly (methacrylic acid-co-ethyleneglycol monomethoacrylate-co-methacryloyloxyethyl 5-amino salicylate) Summary Report |...poly (methacrylic acid-co-ethyleneglycol monomethoacrylate-co-methacryloyloxyethyl 5-amino salicylate) Summary Report |...
poly (methacrylic acid-co-ethyleneglycol monomethoacrylate-co-methacryloyloxyethyl 5-amino salicylate): copolymer that, upon hydrolysis, releases 5-aminosalicylic acid
http://www.curehunter.com/public/keywordSummaryC483606-poly--methacrylic-acid-co-ethyleneglycol-monomethoacrylate-co-methacryloyloxyethyl-5-amino-salicylate-.do
Publications - Latvijas Organiskās sintēzes institūtsPublications - Latvijas Organiskās sintēzes institūts
Markava E.; Gailīte V.; Matisova G.; Freimanis J.; Gerca L.; Muzikante I.; Rutkis M.; Tevosov A.A. Amphiphilic N-acyl-derivatives of azobenzene based on the 4-aminobenzoic and 5-aminosalicylic acids. Mol. Cryst. Liq. Cryst. 1995, 5(3), 215-222 ...
http://www.osi.lv/en/publications/?gads=1995&tips=8&pg=3
1sxk.1 | SWISS-MODEL Template Library1sxk.1 | SWISS-MODEL Template Library
SWISS-MODEL Template Library (SMTL) entry for 1sxk.1. Crystal Structure of a complex formed between phospholipase A2 and a non-specific anti-inflammatory amino salicylic acid at 1.2 A resolution
https://swissmodel.expasy.org/templates/1sxk
help me figure out my next improvements, pleasehelp me figure out my next improvements, please
I have steadily been reducing carbs since the beginning of the year. Over the past month I have kept them to to about 25g daily (40g including fiber).
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Brevet US5010069 - Stable liquid form of 5-aminosalicylic acid - Google BrevetsBrevet US5010069 - Stable liquid form of 5-aminosalicylic acid - Google Brevets
An aqueous solution of 5-aminosalicylic acid (5-ASA) and a nontoxic alkali, alkali metal or alkaline earth metal salt of 5-aminosalicylic acid having a pH of 3-5 is disclosed. The sole buffer in the solution is that intrinsically formed by 5-aminosalicylic acid and its alkali, alkali metal or alkaline earth metal salt. The solutions preferably also contain an antioxidant and a metal complexing agent. In preferrred practice, the 5-ASA salt is formed in situ by addition of an alkali, alkali metal or alkaline earth metal hydroxide to a solution of 5-ASA. The solution is stable and does not significantly discolor due to 5-ASA decomposition for extended periods of time.
http://www.google.fr/patents/US5010069
Aminosalicylate | definition of aminosalicylate by Medical dictionaryAminosalicylate | definition of aminosalicylate by Medical dictionary
Looking for online definition of aminosalicylate in the Medical Dictionary? aminosalicylate explanation free. What is aminosalicylate? Meaning of aminosalicylate medical term. What does aminosalicylate mean?
http://medical-dictionary.thefreedictionary.com/Aminosalicylate
Generic Asacol (Mesalamine) - Online Pharmacy | Fast deliveryGeneric Asacol (Mesalamine) - Online Pharmacy | Fast delivery
Common use. Asacol is an anti-inflammatory drug which acts on the lining of the gut to reduce inflammation tissue damage, and diarrhea and treat ulcerative colitis, proctosigmoiditis, and proctitis. Asacol becomes active in the small intestine just before the large intestine. This drug may be also good in treatment of patients with Crohns disease which affects also the small bowel. Asacol contains active component mesalamine, an anti-inflammatory drug, which is released from covering only when ðÍ,7, and olsalazine (5-aminosalicylic acid dimer) which is also active in distal segments of gastrointestinal tract.. Dosage and direction. Consult with your doctor about necessary dosage before to start treatment. Do not use in larger quantities than prescribed. Take Asacol orally with a meal or a glass of milk. Swallow the whole pill with water. Do not break, crush or chew the tablets before to swallow them. Recommended daily dose for treatment of moderately active ulcerative colitis is 4.8g divided ...
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Proctitis and Anusitis Medication: Corticosteroids, 5-Aminosalicylic Acid Derivatives, Immunosuppressants, Antibiotics,...Proctitis and Anusitis Medication: Corticosteroids, 5-Aminosalicylic Acid Derivatives, Immunosuppressants, Antibiotics,...
Inflammation of the mucosal lining of the rectum is defined as proctitis, whereas anusitis is simply inflammation of the anal canal. Inflammation in these areas can cause symptoms, such as itching, burning, rectal bleeding, pelvic pressure, and foul-smelling discharge.
https://emedicine.medscape.com/article/192910-medication
RJPT - Estimation of Balsalazide in Bulk and in Formulation by UV-Visible SpectrophotometryRJPT - Estimation of Balsalazide in Bulk and in Formulation by UV-Visible Spectrophotometry
Three simple, precise and accurate UV-Visible spectrophotometric methods were developed for the estimation of Balsalazide in bulk drug and in pharmaceutical formulations. In method A, UV spectra of Balsalazide in double distilled water exhibits the absorption maxima at 358 nm. Method B is based on the formation of a dark red colored chromogen in alkaline medium at pH 12 exhibits ? max at 456 nm. Method C is the derivative spectroscopic method. The first derivative spectra were recorded between 200 and 500 nm at N=1 and the assay was carried out by measuring the absorbance at 383 nm. Beers law obeyed in the concentration range of 2-20 ?g/ml for methods A and B and 5-25 ?g/ml for method C. The accuracy of the method was determined by recovery studies. The method were validated statistically. The methods showed good reproducibility and recovery with % RSD less than 2. The methods were found to be simple, economical, accurate and reproducible and can be used for routine analysis of balsalazide in
https://rjptonline.org/AbstractView.aspx?PID=2008-1-4-93
Mesalazine - WikipediaMesalazine - Wikipedia
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohns disease.[2] It is generally used for mildly to moderately severe disease.[2] It is taken by mouth or rectally.[2] The formulations which are taken by mouth appear to be similarly effective.[3] Common side effects include headache, nausea, abdominal pain, and fever.[2] Serious side effects may include pericarditis, liver problems, and kidney problems.[2][3] Use in pregnancy and breastfeeding appears safe.[3] In people with a sulfa allergy certain formulations may result in problems.[2] Mesalazine is an aminosalicylate and anti-inflammatory.[2][3] It works by direct contact with the intestines.[2] Mesalazine was approved for medical use in the United States in 1987.[2][4] It is available as a generic medication and sold under many brand names worldwide.[5][2] A month supply in the United Kingdom costs the NHS about £43 as of ...
https://en.wikipedia.org/wiki/Asacol
Sanatorium treatment of gastritis( in a sanatorium), where they are treated?Sanatorium treatment of gastritis( in a sanatorium), where they are treated?
Many people prefer sanatoria as a treatment option for gastritis. But this is only one of the options offered to the patient. In principle, their mass. But to choose a better individual additional treatment is desirable together with the attending physician. Of course, during a period of exacerbation no resort will be in joy, and not much it can help. Sanatorium treatment of gastritis means rest, proper nutrition and saturation of the body with useful vitamins and minerals, which will have a positive effect on everything as a whole. Gastritis is a common disease that affects a large proportion of the worlds population. Every year, medicine sees an increasing number of patients with this diagnosis. First of all, this is due to improper diet and non-compliance with his regime. In addition, the nerves, tension, bad ecology and stress are detrimental. In addition, not necessarily the emergence of gastritis, many people suffer and other diseases of the gastrointestinal tract. In this case, the main ...
https://treat-simply.com/en/records/4957
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Mesalazine - WikipediaMesalazine - Wikipedia
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is an aminosalicylate anti-inflammatory drug[2] used to treat inflammatory bowel disease, including ulcerative colitis,[3][4][5] or inflamed anus or rectum,[6] and to maintain remission in Crohns disease.[3][7] It is sold in an oral form to maintain remission in ulcerative colitis and Crohns disease,[3] and as a rectal suppository[4][6] and an enema for the lower bowel conditions.[5] It is generic and sold under many brand names worldwide,[1] and there are many formulations.[8] There are no data on use in pregnant women, but the drug does cross the placenta and is excreted in breast milk. The drug should not be used in children under two, people with kidney disease, or people who are allergic to aspirin.[4] Side effects are primarily gastrointestinal but may also include headache; GI effects include nausea, diarrhea and abdominal pain. There have been scattered reports of various problems when the oral form is used, ...
https://en.wikipedia.org/wiki/Pentasa
Balsalazide Disodium - patient information, description, dosage and directions.Balsalazide Disodium - patient information, description, dosage and directions.
Description of the drug Balsalazide Disodium. - patient information, description, dosage and directions. What is Balsalazide Disodium!
http://drugster.info/drug/medicament/2760/
Asacol - Asacol price, Asacol generic 2017Asacol - Asacol price, Asacol generic 2017
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Visible light absorption of surface modified TiO2 powders with bidentate benzene derivativesVisible light absorption of surface modified TiO2 powders with bidentate benzene derivatives
TY - JOUR AU - Milicevic, B AU - Đorđević, Vesna AU - Lončarević, Davor AU - Ahrenkiel, Scott Phillip AU - Dramićanin, Miroslav AU - Nedeljković, Jovan M. PY - 2015 UR - http://cer.ihtm.bg.ac.rs/handle/123456789/1721 AB - TiO2 powders with different specific surface area were prepared using reproducible, sol gel synthetic route and their ability to form hybrids with catechol and 5-amino salicylic acid was compared with the commercially available Degussa P25 TiO2 powder. Microstructural characterization involving transmission electron microscopy, X-ray diffraction analysis and nitrogen adsorption-desorption isotherms indicated that TiO2 samples cover reasonably wide size and/or specific surface area range (50-115 m(2)/g). The surface modification of TiO2 powders with catechol and 5-amino salicylic acid induced significant shift of absorption to the visible spectral region due to charge transfer complex formation. It should be emphasized that tunable optical properties of TiO2 in powder ...
https://cer.ihtm.bg.ac.rs/handle/123456789/1721
Mesalazine EP Impurity E | Anant Pharmaceuticals Pvt. Ltd.Mesalazine EP Impurity E | Anant Pharmaceuticals Pvt. Ltd.
Mesalazine EP Impurity E ; 4-amino-2-hydroxybenzoic acid ; 4-Aminosalicylic acid ; 65-49-6 Cas ; Mesalazine Impurities ; Impurity of Mesalazine
http://anantlabs.com/mesalazine-impurity-e/
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2021 Ulcerative Colitis Clinical Trials, Research & Treatment2021 Ulcerative Colitis Clinical Trials, Research & Treatment
Ulcerative colitis treatment consists of a variety of approaches. Most patients can control their symptoms with ulcerative colitis drugs. In general, ulcerative colitis surgery is reserved for the most severe cases and those in which standard ulcerative colitis medication is ineffective.. 5-aminosalicylic acid (5-ASA) drugs are the most common ulcerative colitis medications. Corticosteroids are used for short-term treatment of moderate symptoms. Severe cases receive immunomodulators, which reduce inflammation but slow the bodys immune response.. Surgery can be used to remove damaged areas of the digestive tract. In profound cases, ulcerative colitis may be eliminated by removing the colon and rectum completely, a procedure called proctocolectomy.. ...
https://policylab.us/clinical-trials/ulcerative-colitis/
Ulcerative colitis: conservative management and long-term effects. | IKMBUlcerative colitis: conservative management and long-term effects. | IKMB
Ulcerative colitis is characterized by chronic inflammation of the colon. Typical symptoms are diarrhoea, rectal bleeding, abdominal pain and fever. The aetiology of the disease is unclear. The inflammation can be localized in the rectum or can extend to the left side or the whole colon. Treatment for induction and remission maintenance depends on the severity and extension of mucosal inflammation. Topical 5-aminosalicylates have been shown in studies to be the treatment of choice in mild to moderate ulcerative colitis. Oral 5-aminosalicylates can be used in distal, mild and moderate ulcerative colitis and for remission maintenance. For patients with a more extended or severe inflammation, oral or i.v. corticosteroids should be used. Patients with severe and/or chronic disease require immunosuppressive therapy with azathioprine or 6-mercaptopurine. For patients with severe, chronic, refractory disease, cyclosporine i.v. can be used. If no response to treatment is seen, proctocolectomy should be ...
http://www.ikmb.uni-kiel.de/publications/ulcerative-colitis-conservative-management-and-long-term-effects
January 2018 - When do the patents on POTASSIUM AMINOSALICYLATE expire, and when will generic POTASSIUM AMINOSALICYLATE be...January 2018 - When do the patents on POTASSIUM AMINOSALICYLATE expire, and when will generic POTASSIUM AMINOSALICYLATE be...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
https://www.drugpatentwatch.com/p/tradename/POTASSIUM+AMINOSALICYLATE
Intracolonic Release in Vivo of Interleukin-1β in Chronic Ulcerative Colitis | Clinical ScienceIntracolonic Release in Vivo of Interleukin-1β in Chronic Ulcerative Colitis | Clinical Science
1. To investigate the role of interleukin-1β in chronic ulcerative colitis, we quantified interleukin-1β steady-state release into the colonic lumen.. 2. We studied 26 patients with untreated chronic ulcerative colitis and seven patients with irritable bowel syndrome who served as disease controls. In seven ulcerative colitis patients, the disease was inactive and in 19 it was mild to moderately active, according to clinical and colonoscopic criteria. Seven patients with active colitis were studied before and after 4 weeks of treatment with oral 5-aminosalicylic acid.. 3. Colonic perfusions were performed using a double-lumen technique. An isotonic solution was continuously infused 50 cm from the anal verge at 5 ml/min, and was recovered 30 cm distally by siphonage. Interleukin-1β was measured by ELISA, polymorphonuclear elastase by immunoactivation and leukotriene B4 by specific RIA.. 4. All control patients and five out of seven patients with inactive colitis had undetectable ...
http://www.clinsci.org/content/89/5/521
Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugsRegulation of gene expression in inflammatory bowel disease and correlation with IBD drugs
Potential biomarkers for Crohns disease (CD) and ulcerative colitis (UC) were identified from two sets of full thickness pathologic samples utilizing DermArray® and PharmArray® DNA microarrays relative to uninvolved (Un) colon or normal colon. Seven of the over-expressed genes were verified using quantitative RT-PCR (i.e., TMPT, FABP1, IFI27, LCN2, COL11A2, HXB, and metallothionein). By correlating gene expression profiles between inflammatory bowel disease (IBD) tissue samples and IBD drug-treated cell cultures it might be possible to identify new candidate molecular target genes for IBD therapy and drug discovery. Potential biomarkers for CaCo2 cell cultures, which are routinely used as a GI tract surrogate model for in vitro pharmacokinetic studies, treated with azathioprine, 5-aminosalicylic acid, metronidazole, and prednisone were also identified from another experiment. Metallothionein mRNA expression was found to be down-regulated in azathioprine-treated CaCo2 cells, and was ...
http://scholars.uab.edu/display/pub894597
PREVALENCE AND MANAGEMENT OF INFLAMMATORY BOWEL DISEASE: DATA FROM PRIMARY CARE RECORDS, INCLUDING 5-ASA PRESCRIBING AND...PREVALENCE AND MANAGEMENT OF INFLAMMATORY BOWEL DISEASE: DATA FROM PRIMARY CARE RECORDS, INCLUDING 5-ASA PRESCRIBING AND...
Background: Data from general practice (GP) records in North Tees (Rubin et al, 2000) suggested a higher prevalence of inflammatory bowel disease (IBD) than previous estimates from hospital data. Regular prescribing of 5-aminosalicylic acid (5-ASA) therapy can reduce the risk of colorectal cancer in patients with ulcerative colitis (UC). Aims: To estimate IBD prevalence from GP records in the Trent region of central England and describe the management of patients with this condition, including data regarding 5-ASA prescribing and compliance in UC. Methods: 15 general practices recruited through the Trent Focus Collaborative Research Network provided data on confirmed cases of IBD using a standardised data collection form. Results: 344 patients with IBD were identified from a combined GP list size of 86 801, suggesting a prevalence of 396 per 100 000 (95% confidence interval 356 to 440), much higher than previous estimates from secondary care and similar to results from North Tees. Approximately ...
http://connection.ebscohost.com/c/articles/9747747/prevalence-management-inflammatory-bowel-disease-data-from-primary-care-records-including-5-asa-prescribing-compliance
Sulfasalazine | CTDSulfasalazine | CTD
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907 ...
http://ctdbase.org/detail.go?type=chem&acc=D012460
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohns Disease, and Pouchitis: Meta...Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohns Disease, and Pouchitis: Meta...
Administration of probiotics results in additional benefit in inducing remission of patients with UC. VSL#3 are beneficial for maintaining remission in patients with pouchitis. And, probiotics can provide the similar effect as 5-aminosalicylic acid on maintaining remission of UC, although no additio …
https://pubmed.ncbi.nlm.nih.gov/24280877/?dopt=Abstract
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What are the goals of pharmacotherapy in pediatric Crohn disease?What are the goals of pharmacotherapy in pediatric Crohn disease?
The goals of pharmacotherapy in Crohn disease are to reduce morbidity and prevent complications. Agent classes used include 5-aminosalicylic acid (5-ASA) derivatives, corticosteroids, immunosuppressiv... more
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Harvesting lab-raised zebrafish based on their size led to differences in the activity of more than 4,000 genes, as well as changes in allele frequencies of those genes, in the fish that remained.. 0 Comments. ...
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Peroxisome proliferator‐activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut | EMBO Molecular...Peroxisome proliferator‐activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut | EMBO Molecular...
Gene expression profiles of the Caco‐2 intestinal epithelial cell line stimulated by PPARγ agonists were first assessed by microarray analysis. We used three different PPARγ agonist: the well‐characterized pioglitazone (Pio; 1 μM) belonging to the TZD drug class (Momose et al, 1991), 5‐amino salicylic acid (5‐ASA, 30 mM) (Rousseaux et al, 2005), and a new PPARγ modulator we developed and named GED‐0507‐34‐Levo (GED; 1 and 30 mM) (Pirat et al, 2012; Mastrofrancesco et al, 2014). Among the 44,000 genes tested, we observed that the LCT gene was the most upregulated gene in cells treated with Pio and GED. The LCT gene was significantly 5.28‐fold (± 0.55; P , 0.05) upregulated by 1 mM GED, 8.28‐fold (± 1.7; P , 0.05) upregulated by 30 mM GED and 17.93‐fold (± 5.1; P , 0.05) upregulated for Pio compared to unstimulated cells. 5‐ASA also upregulated LCT mRNA expression to the same extend (8.76‐fold ± 2.06, P , 0.05) (GEO Series accession number GSE68852; ...
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Schedule HSchedule H
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ATC code J04ATC code J04
J04AA Aminosalicylic acid and derivatives[edit]. J04AA01 Aminosalicylic acid. J04AA02 Sodium aminosalicylate. J04AA03 Calcium ...
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Ulcerative colitisUlcerative colitis
In 1977, it was shown that 5-aminosalicylic acid (5-ASA, mesalazine/mesalamine) was the therapeutically active component in ... Marshall JK, Thabane M, Steinhart AH, Newman JR, Anand A, Irvine EJ (November 2012). "Rectal 5-aminosalicylic acid for ... "Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis". The Cochrane Database of Systematic Reviews. 8: ... "Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis". The Cochrane Database of Systematic Reviews. 8 ...
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CateninCatenin
"The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
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Asid 4-Aminosalicylig - WicipediaAsid 4-Aminosalicylig - Wicipedia
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Management of ulcerative colitisManagement of ulcerative colitis
The anti-inflammatory action in all these drugs is produced by 5-aminosalicylic acid (5-ASA), the active ingredient in ... The aminosalicylates used to treat ulcerative colitis include the following: Mesalazine, also known as 5-aminosalicylic acid, ... "MedlinePlus Herbs and Supplements: Omega-3 fatty acids, fish oil, alpha-linolenic acid". Archived from the original on May 18, ... Folic acid might also be counter-productive for patients taking 6-MP and related drugs that inhibit all cell division. It is ...
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MesalazineMesalazine
... , also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
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SalicylamideSalicylamide
4-Aminosalicylic acid Mesalazine Salsalate "Salicylamide". Dictionary.com. Merriam-Webster's Medical Dictionary. Merriam- ...
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MesalazineMesalazine
... , also known as mesalamine or 5-aminosalicylic acid (5-ASA), is an aminosalicylate anti-inflammatory drug[2] used to ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
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Sasanka Chandra BhattacharyyaSasanka Chandra Bhattacharyya
"4-Aminosalicylic acid and its derivatives. Part II. The synthesis of 4-amino-2 : 5- and 4-amino-2 : 3-dihydroxybenzoic acid". J ... S. C. Bhattacharyya, B. Lythgoe (12 February 1949). "Triterpene Acids". Nature. 163 (4137): 259. Bibcode:1949Natur.163..259B. ... 105 (1). S. C. Bhattacharyya, B. Lythgoe (12 February 1949). "Triterpene Acids". Nature. 163 (4137): 259. Bibcode:1949Natur.163 ...
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Solute carrier family 38 member 9Solute carrier family 38 member 9
"New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid". PLOS ... Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1". Science. 347 (6218): 188-94. doi:10.1126/ ... Jung J, Genau HM, Behrends C (July 2015). "Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9". ... "SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1". Nature. 519 (7544): 477-81. doi: ...
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SulfasalazineSulfasalazine
It is a codrug which is a combination of sulfapyridine and 5-aminosalicylic acid coupled with an azo linkage.[citation needed] ... The medication is broken down by intestinal bacteria into sulfapyridine and 5-aminosalicylic acid. That which is absorbed is ... also known as 5-aminosalicylic acid or 5-ASA). Both metabolites are active; most of the sulfapyridine is absorbed and then ... "Folic Acid Antagonists during Pregnancy and the Risk of Birth Defects". New England Journal of Medicine. 343 (22): 1608-14. doi ...
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Irritable bowel syndromeIrritable bowel syndrome
There is increasing evidence for the effectiveness of mesalazine (5-aminosalicylic acid) in the treatment of IBS. Mesalazine is ... Klotz U (February 2012). "The pharmacological profile and clinical use of mesalazine (5-aminosalicylic acid)". Arzneimittel- ... Bile acid malabsorption is also sometimes missed in people with diarrhea-predominant IBS. SeHCAT tests suggest around 30% of ... Andoh A, Tsujikawa T, Fujiyama Y (2003). "Role of dietary fiber and short-chain fatty acids in the colon". Current ...
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N-acetyltransferaseN-acetyltransferase
Human NAT1 preferentially acetylates 4-aminobenzoic acid (PABA), 4 amino salicylic acid, sulfamethoxazole, and sulfanilamide. ... Polymorphisms of NAT2 include the single amino acid substitutions R64Q, I114T, D122N, L137F, Q145P, R197Q, and G286E. These are ... of their amino acid sequence. Both also have an active site cysteine residue (Cys68) in the N-terminal region. Further, all ...
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ThioacetazoneThioacetazone
These were found in a treatment combining conteben with PAS acid p-amino-salicylic acid. Thiosemicarbazide John Buckingham (2 ... and p-Amino-Salicylic Acid". Acta Medica Scandinavica. 143 (5): 323-335. doi:10.1111/j.0954-6820.1952.tb14267.x. PMID 12976024 ... although it is thought to interfere with mycolic acid synthesis. One of the documented adverse effects of thioacetazone is the ...
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Lloyd MayerLloyd Mayer
Murphy, Seamus Joseph; Mayer, Lloyd; Abreu, Maria T. (January 2011). "Mesalamine (5-aminosalicylic acid) therapy well tolerated ...
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BalsalazideBalsalazide
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CodrugCodrug
Sulfasalazine, which is a combination of sulfapyridine and 5-aminosalicylic acid coupled with an azo linkage. It is on the ... Some examples of codrugs: Benorylate, which is an esterified product of paracetamol and acetylsalicylic acid Fenethylline, ... an amino acid with minimal biological effects in this case, to maintain steady concentration for 12-16 hours; often used for a ...
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Niacin testNiacin test
The niacin test strip is typically composed of potassium thiocyanate, chloramine-T, citric acid, and 4-Aminosalicylic acid. In ... Because lab samples that are determined to be acid-fast bacilli are possibly M. tuberculosis, a biosafety level 3 organism, all ... The niacin test detects niacin (nicotinic acid) in aqueous extracts of a culture. M. tuberculosis strains that test negative ... the presence of citric acid, chloramine-T and potassium thiocyanate will react to form cyanogen chloride. This chemical will ...
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OlsalazineOlsalazine
It is absorbed in the small intestine and broken down into two molecules of 5-aminosalicylic acid (5-ASA). Olsalazine gained ...
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University Hospital of South Manchester NHS Foundation TrustUniversity Hospital of South Manchester NHS Foundation Trust
In 1957 when Streptomycin and Para-Aminosalicylic acid were used for prolonged chemotherapy surgery was no longer needed for TB ...
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Firland SanatoriumFirland Sanatorium
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RifampicinRifampicin
4-Aminosalicylic acid (another antituberculosis drug) significantly reduces absorption of rifampicin, and peak concentrations ... Cluster I is amino acids 509 to 533, cluster II is amino acids 563 to 572, and cluster III is amino acid 687. When describing ... Charity JC, Katz E, Moss B (March 2007). "Amino acid substitutions at multiple sites within the vaccinia virus D13 scaffold ... A change in amino acid 531 from serine to leucine arising from a change in the DNA sequence of TCG to TTG is the most common ...
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AminosalicylateAminosalicylate
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Tine testTine test
4-Aminosalicylic acid. *Ethambutol. *Capreomycin. *Cycloserine. *Rifampicin. *Thioacetazone. *Streptomycin. *Bedaquiline. * ...
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Category:World Health Organization essential medicinesCategory:World Health Organization essential medicines
4-Aminosalicylic acid. *Amiodarone. *Amitriptyline. *Amlodipine. *Amodiaquine. *Amoxicillin. *Amoxicillin/clavulanic acid. * ...
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Category:Drugboxes which contain changes to watched fieldsCategory:Drugboxes which contain changes to watched fields
Aminomethylbenzoic acid. *Aminometradine. *Aminophenazone. *Aminophylline. *5-APDB. *Aminorex. *4-Aminosalicylic acid. * ...
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Collagenous colitisCollagenous colitis
5-aminosalicylic acid. *Budesonide. *Immunosuppressants, including azathioprine. *Corticosteroids. Pilot-scale studies have ...
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Category:Portal templates with redlinked portalsCategory:Portal templates with redlinked portals
4-Aminosalicylic acid. *Amiodarone. *Amitriptyline. *Amlodipine. *Amodiaquine. *Amoxicillin. *Amoxicillin/clavulanic acid. * ...
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SelexipagSelexipag
... the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. ... Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
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KetorolacKetorolac
The risk of bleeding increases with the concurrent medications clopidogrel, cefoperazone, valproic acid, cefotetan, ... Chemically ketorolac functions as a carboxylic acid derivative serving non-selectively to block the prostaglandin synthesis by ... Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
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Fenamic acidFenamic acid
... including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. These drugs are commonly referred to as " ... "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid.[2]:235[3]:17[2] ... Fenamic acid is an organic compound, which, especially in its ester form, is called fenamate.[1]:458 serves as a parent ... synthesis of Fenamic acid: C. F. H. Allen, G. H. W. McKee (1939). "Acridone". 2: 6. doi:10.15227/orgsyn.019.0006.. .mw-parser- ...
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BenorilateBenorilate
Simila S, Keinanen S, Kouvalainen K.Oral antipyretic therapy: evaluation of benorylate, an ester of acetylsalicylic acid and ... Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
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Shepard C (1960). "Acid-fast bacilli in nasal excretions in leprosy, and results of inoculation of mice". Am J Hyg. 71: 147-57 ...
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negative regulation of gastric acid secretion. • phospholipase C-activating G-protein coupled receptor signaling pathway. • ... "Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain ... Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
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https://en.wikipedia.org/wiki/Rofecoxib
AspirinAspirin
2-acetoxybenzoic acid. acetylsalicylate. acetylsalicylic acid. O-acetylsalicylic acid, Aspirin (BAN UK), Aspirin (USAN US). ... Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's ... Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic ... Small amounts of sulfuric acid (and occasionally phosphoric acid) are almost always used as a catalyst. This method is commonly ...
https://en.wikipedia.org/wiki/Acetylsalicylic_acid
DiglycerideDiglyceride
Since diacylglycerol is synthesized via phosphatidic acid, it will usually contain a saturated fatty acid at the C-1 position ... or free fatty acids.(See Dietary sources of fatty acids, their digestion, absorption, transport in the blood and storage for ... to form lysophosphatidic acid, which is then acylated with another molecule of acyl-CoA to yield phosphatidic acid. ... A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol ...
https://en.wikipedia.org/wiki/Diglyceride
Cysteinyl leukotriene receptor 2Cysteinyl leukotriene receptor 2
Polymorphism in the CysLTR2 gene resulting in a single amino acid substitution, M201V (i.e. amino acid methionine changed for ... CysLTR2 encodes a protein composed of 347 amino acids and shows only modest similarity to the CysLTR1 gene in that its protein ... shares only 31% amino acid identity with the CysLTR1 protein.[9][10][11] ... Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ...
https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_2
gamma-Linolenic acidgamma-Linolenic acid
... or GLA (γ-linolenic acid), (INN and USAN gamolenic acid) is a fatty acid found primarily in seed oils. ... This article is about gamma-Linolenic acid. For α-Linolenic acid, see alpha-Linolenic acid. For linoleic acid (no "n"), see ... It is an isomer of α-linolenic acid, which is a polyunsaturated n−3 (omega-3) fatty acid, found in rapeseed canola oil, ... Although GLA is an n−6 fatty acid, a type of acid that is, in general, pro-inflammatory, it has anti-inflammatory properties. ( ...
https://en.wikipedia.org/wiki/Gamma-Linolenic_acid
Prostaglandin receptorProstaglandin receptor
... they metabolize gamma-Linolenic acid, which has one less double bond than arachidonic acid, to series 1 prostanoids (PGD1, PGE1 ... Prostanoid receptors bind and respond principally to metabolites of the straight chain polyunsaturated fatty acid (PUFA), ... However, the same enzymes that metabolize arachidonic acid to series 2 prostanoids similarly metabolize two other straight ... arachidonic acid. These metabolites contain two double bonds and are named series 2 prostanoids, i.e. PGD2, PGE2, PGF2α, PGI2, ...
https://en.wikipedia.org/wiki/Prostaglandin_receptor
Mefenamic acid, ang malayang ensiklopedyaMefenamic acid, ang malayang ensiklopedya
Mefenamic acid (mefenamate). *Meloxicam. *Menatetrenone (vitamin K2). *Mesalazine (5-aminosalicylic acid) ... Tulad ng sa fenamic acid, ang kompuwestong ito ay maaaring buuin mula sa 2-chlorobenzoic acid at 2,3-dimethylaniline.[9] ... Ang Mefenamic acid o Asidong mefenamiko ay isang miyembro ng klaseng deribatibong asidong anthraniliko (o fenamate) ng mga ... "Side effects for Mefenamic Acid". Medline Plus. National Institutes of Health.. *↑ Prusakiewicz JJ et al. Differential ...
https://tl.wikipedia.org/wiki/Mefenamic_acid
WHO Model List of Essential MedicinesWHO Model List of Essential Medicines
P-aminosalicylic acidα. *Streptomycinα. Antifungal medicines[edit]. *Amphotericin B. *Clotrimazole ... Acetylsalicylic acid (aspirin)[note 90]. Notes[edit]. An α indicates the medicine is only on the complementary list. For these ... Solutions correcting water, electrolyte and acid-base disturbances[edit]. Oral[edit]. *Oral rehydration salts ...
https://en.wikipedia.org/wiki/List_of_World_Health_Organization_Essential_Medicines
Padron:Prostanoidergics, ang malayang ensiklopedyaPadron:Prostanoidergics, ang malayang ensiklopedya
Mefenamic acid (mefenamate). *Meloxicam. *Menatetrenone (vitamin K2). *Mesalazine (5-aminosalicylic acid) ...
https://tl.wikipedia.org/wiki/Padron:Prostanoidergics
Catenina, a enciclopedia libreCatenina, a enciclopedia libre
"The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
https://gl.m.wikipedia.org/wiki/Catenina
COX-2 inhibitorCOX-2 inhibitor
Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
https://en.wikipedia.org/wiki/COX_inhibitor
Prostaglandin DP2 receptorProstaglandin DP2 receptor
... composed of 472 amino acids. DP2, is related to members of the chemotactic factor class of GPCRs, sharing an amino acid ... DP2 has little or no such amino acid sequence relationship to the eight other Prostanoid receptors (see Eicosanoid receptor# ... Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
https://en.wikipedia.org/wiki/GPR44
VancomycinVancomycin
This binding of vancomycin to the D-Ala-D-Ala prevents cell wall synthesis of the long polymers of N-acetylmuramic acid (NAM) ... Before vancomycin is assembled through NRPS, the amino acids are first modified. L-tyrosine is modified to become the β- ... Nonribosomal peptide synthesis occurs through distinct modules that can load and extend the protein by one amino acid through ... In the A domain, the specific amino acid is activated by converting into an aminoacyl adenylate enzyme complex attached to a ...
https://en.wikipedia.org/wiki/Vancomycin_hydrochloride
Prostaglandin F2alphaProstaglandin F2alpha
Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)- 3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid ... First, Phospholipase A2 (PLA2) facilitates the conversion of phospholipids to Arachidonic Acid, the framework from which all ... prostaglandins are formed.[8] The Arachidonic Acid then reacts with two Cyclooxygenase (COX) receptors, COX-1 and COX-2 to form ... Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ...
https://en.wikipedia.org/wiki/Prostaglandin_F2alpha
TafluprostTafluprost
... acid is inactivated by beta oxidation to 1,2-dinortafluprost acid, 1,2,3,4-tetranortafluprost acid, and its lactone ... Tafluprost, as a lipophilic ester, easily penetrates the cornea and is then activated to the carboxylic acid, tafluprost acid. ... From left to right: tafluprost, tafluprost acid (the active metabolite), 1,2-dinortafluprost acid, 1,2,3,4-tetranortafluprost ... Tafluprost is a prodrug of the active substance, tafluprost acid, a structural and functional analogue of prostaglandin F2α ( ...
https://en.wikipedia.org/wiki/Tafluprost
ThromboxaneThromboxane
Omega-3 fatty acids are metabolized to produce higher levels of TxA,3 which is relatively less potent than TxA2 and PGI3; ... Thromboxane-A synthase, an enzyme found in platelets, converts the arachidonic acid derivative prostaglandin H2 to thromboxane ... Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
https://en.wikipedia.org/wiki/Thromboxane_inhibitors
Aminosalicylic acid - WikipediaAminosalicylic acid - Wikipedia
3-Aminosalicylic acid 4-Aminosalicylic acid (para-aminosalicylic acid, PAS) 5-Aminosalicylic acid (mesalazine) 6-Aminosalicylic ... Aminosalicylic acid can refer to any amino derivative of salicylic acid, such as: ... acid This set index page lists chemical compounds articles associated with the same name. If an internal link led you here, you ...
https://en.wikipedia.org/wiki/Aminosalicylic_acid
Jaundice and Para-aminosalicylic Acid | The BMJJaundice and Para-aminosalicylic Acid | The BMJ
Jaundice and Para-aminosalicylic Acid. Br Med J 1950; 2 doi: https://doi.org/10.1136/bmj.2.4685.949 (Published 21 October 1950) ...
http://www.bmj.com/content/2/4685/949.1
4-Aminosalicylic acid - Wikipedia4-Aminosalicylic acid - Wikipedia
4-aminosalicylic acid has many names including para-aminosalicylic acid, p-aminosalicylic acid, 4-ASA, and simply P.[medical ... 4-Aminosalicylic acid is believed to work by blocking the ability of bacteria to make folic acid. 4-Aminosalicylic acid was ... 4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) and sold under the brand name Paser among others, is an ... With heat, aminosalicylic acid is decarboxylated to produce CO2 and 3-aminophenol. 4-aminosalicylic acid has been shown to be a ...
https://en.wikipedia.org/wiki/4-Aminosalicylic_acid
3-Aminosalicylic acid3-Aminosalicylic acid
Other names: Benzoic acid, 3-amino-2-hydroxy-; Salicylic acid, 3-amino- ...
https://webbook.nist.gov/cgi/inchi/InChI%3D1S/C7H7NO3/c8-5-3-1-2-4
Aminosalicylic Acid: Indications, Side Effects, Warnings - Drugs.comAminosalicylic Acid: Indications, Side Effects, Warnings - Drugs.com
Easy to read patient leaflet for Aminosalicylic Acid. Includes indications, proper use, special instructions, precautions, and ... Aminosalicylic Acid. Generic Name: Aminosalicylic Acid (a mee noe sal i SIL ik AS id). Brand Name: Paser ... What do I need to tell my doctor BEFORE I take Aminosalicylic Acid?. *If you have an allergy to aminosalicylic acid or any ... How is this medicine (Aminosalicylic Acid) best taken?. Use aminosalicylic acid as ordered by your doctor. Read all information ...
https://www.drugs.com/cdi/aminosalicylic-acid.html
Paser (Aminosalicylic Acid): Side Effects, Interactions, Warning, Dosage & UsesPaser (Aminosalicylic Acid): Side Effects, Interactions, Warning, Dosage & Uses
Aminosalicylic Acid) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... PASER (aminosalicylic acid) granules are a delayed release granule preparation of aminosalicylic acid (p-aminosalicylic acid: 4 ... Aminosalicylic acid (p-aminosalicylic acid) is 4-Amino-2-hydroxybenzoic acid. PASER granules are the free base of ... Aminosalicylic acid is rapidly degraded in acid media; the protective acid-resistant outer coating is rapidly dissolved in ...
https://www.rxlist.com/paser-drug.htm
Patent US6380386 - Substituted aminosalicylic acid amides with fungicidal effect and ... - Google PatentsPatent US6380386 - Substituted aminosalicylic acid amides with fungicidal effect and ... - Google Patents
... acids, such as, for example, hydrochloric acid or acetic acid, and also any mixtures of the abovementioned diluents. ... Substituted aminosalicylic acid amides with fungicidal effect and intermediate products for production thereof. US 6380386 B2 ... 2049-2050, Goldberg et al, 6-Aminosalicylic Acid: The Hydrolysis of 2-Carboxytrinitrodiphenyl Ethers. ... Substituted aminosalicylic acid amides with fungicidal effect and intermediate products for production thereof. ...
http://www.google.com/patents/US6380386?dq=5,867,764
Aminosalicylic Acid - DrugBankAminosalicylic Acid - DrugBank
The sodium salt of the drug is better tolerated than the free acid. ... Aminosalicylic acids. Alternative Parents. 4-aminosalicylic acids / Salicylic acids / Aminobenzoic acids / Benzoic acids / m- ... 4-aminosalicylic acid / Aminosalicylic acid / Salicylic acid / Aminobenzoic acid or derivatives / Aminobenzoic acid / Benzoic ... 4-Aminosalicylic_acid. ATC Codes. J04AA01 - 4-aminosalicylic acid*J04AA - Aminosalicylic acid and derivatives ...
https://www.drugbank.ca/drugs/DB00233
4-aminosalicylic acid - Substance Information - ECHA4-aminosalicylic acid - Substance Information - ECHA
4-aminosalicylic acid. Regulatory process names 2 IUPAC names 1 Other identifiers 1 ...
https://www.echa.europa.eu/web/guest/substance-information/-/substanceinfo/100.000.557
5-Aminosalicylic acid - 5-Amino-2-hydroxybenzoic acid, Mesalamine5-Aminosalicylic acid - 5-Amino-2-hydroxybenzoic acid, Mesalamine
Synonyms: 5-Amino-2-hydroxybenzoic acid, Mesalamine, 5-AS. CAS 89-57-6. Molecular Weight 153.14. Browse 5-Aminosalicylic acid ...
https://www.sigmaaldrich.com/US/en/substance/5aminosalicylicacid1531489576
Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular TrapsFlavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps
We observed that the flavonoids epicatechin and rutin trihydrate as well as ascorbic acid and 5-aminosalicylic acid (5-ASA) ... 5-aminosalicylic acid (0.005, 0.25, 0.5 mM, 5-ASA, TCI Europe N.V., Eschborn, Germany), acetylsalicylic acid (1 mM, ASS), and N ... urea and acetylsalicylic acid (ASS), and (h) 5-aminosalicylic acid (5-ASA) was quantified by calculation of the area under the ... urea and actetylsalicylic acid (ASS), and (h) 5-aminosalicylic acid (5-ASA) was quantified by calculation of the area under the ...
https://www.hindawi.com/journals/mi/2013/710239/
Aminosalicylic acid - wikidocAminosalicylic acid - wikidoc
Aminosalicylic acid (p-aminosalicylic acid) is 4-Amino-2-hydroxybenzoic acid. aminosalicylic acid granules are the free base of ... Aminosalicylic acid granules are a delayed release granule preparation of aminosalicylic acid (p-aminosalicylic acid; 4- ... Aminosalicylic acid is rapidly degraded in acid media; the protective acid-resistant outer coating is rapidly dissolved in ... Aminosalicylic acid granules are supplied in packets containing 4 grams of aminosalicylic acid for administration three times a ...
https://www.wikidoc.org/index.php/Sodium_aminosalicylate
5-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats5-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats
We tested the hypothesis that 5-aminosalicylic acid (5-ASA) inhibits toxin A-induced generation of colonic leukotriene B,sub,4 ... P. A. M. Van Hees, J. H. Bakker, and J. H. M. van Tongeren, "Effect of sulphapyridine, 5-aminosalicylic acid, and placebo in ... R. P. MacDermott, "Progress in understanding the mechanisms of action of 5-aminosalicylic acid," The American Journal of ... 5-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats. ...
https://www.hindawi.com/journals/iji/2014/389621/
Recent Articles | Para-aminosalicylic Acid, Ecology And Immunology | The Scientist Magazine®Recent Articles | Para-aminosalicylic Acid, Ecology And Immunology | The Scientist Magazine®
A single receptor on natural killer cells recognizes an amino acid sequence conserved across Zika, dengue, and related ... tags: para-aminosalicylic acid x ecology x immunology x The Scientist. » para-aminosalicylic acid, ecology and immunology ...
https://www.the-scientist.com/?articles.list/categoryNo/2625/category/The-Scientist/tagNo/2993,7,12/tags/para-aminosalicylic-acid,ecology,immunology/
5-Aminosalicylic Acid Prices & Coupons | PharmacyChecker.com5-Aminosalicylic Acid Prices & Coupons | PharmacyChecker.com
Print free coupons for 5-aminosalicylic acid and find the best deal on your prescription medications today. ... Compare 5-aminosalicylic acid (mesalamine) prices at pharmacies near me. ... 5-Aminosalicylic Acid Prices - (mesalamine) 5-aminosalicylic acid (mesalamine) discount prices at U.S. pharmacies start at . ... 5-aminosalicylic acid (mesalamine) discount prices at U.S. pharmacies start at . Enter your ZIP Code to compare discount 5- ...
https://www.pharmacychecker.com/5-aminosalicylic+acid/?package_size=100.0&formulation=Powder
Recent Articles | Para-aminosalicylic Acid And Immunology | The Scientist Magazine®| Page 12Recent Articles | Para-aminosalicylic Acid And Immunology | The Scientist Magazine®| Page 12
tags: para-aminosalicylic acid x immunology x The Scientist. » para-aminosalicylic acid and immunology ...
https://www.the-scientist.com/?articles.list/tagNo/2993,12/tags/para-aminosalicylic-acid,immunology/pageNo/12/
Para-aminosalicylic acid | definition of para-aminosalicylic acid by Medical dictionaryPara-aminosalicylic acid | definition of para-aminosalicylic acid by Medical dictionary
What is para-aminosalicylic acid? Meaning of para-aminosalicylic acid medical term. What does para-aminosalicylic acid mean? ... Looking for online definition of para-aminosalicylic acid in the Medical Dictionary? para-aminosalicylic acid explanation free ... para-aminosalicylic acid. /para-ami·no·sal·i·cyl·ic ac·id/ (-ah-me″no-sal-ĭ-sil´ik) aminosalicylic acid.. para-aminosalicylic ... Related to para-aminosalicylic acid: Sodium aminosalicylate. p-aminosalicylic acid. (PAS) (PASA) [ah-me″no-sal-ĭ-sil´ik] an ...
https://medical-dictionary.thefreedictionary.com/para-aminosalicylic+acid
How does p-aminosalicylic acid treat tuberculosis? | Anti-Infective Agent - SharecareHow does p-aminosalicylic acid treat tuberculosis? | Anti-Infective Agent - Sharecare
P-aminosalicylic acid is an antibiotic medication that works by killing or slowing down the bacteria that cause tuberculosis. ... P-aminosalicylic acid is an antibiotic medication that works by killing or slowing down the bacteria that cause tuberculosis. ... However, the exact manner in which P-aminosalicylic acid works is still being studied. ...
https://www.sharecare.com/health/anti-infective-drugs/how-p-aminosalicylic-treat-tuberculosis
Which medications in the drug class 5-Aminosalicylic Acid Derivatives are used in the treatment of Crohn Disease?Which medications in the drug class 5-Aminosalicylic Acid Derivatives are used in the treatment of Crohn Disease?
5-Aminosalicylic Acid DerivativesThe 5-ASA derivative agents are used to treat mild-to-moderate Crohn disease and to maintain ... 5-Aminosalicylic Acid Derivatives. The 5-ASA derivative agents are used to treat mild-to-moderate Crohn disease and to maintain ... Which medications in the drug class 5-Aminosalicylic Acid Derivatives are used in the treatment of Crohn Disease?. Updated: Jul ...
https://www.medscape.com/answers/172940-18372/1986158-overview
Ocular Cicatricial Pemphigoid (OCP) Medication: Antibiotics, Immunosuppressive agents, Systemic steroids, Aminosalicylic acid...Ocular Cicatricial Pemphigoid (OCP) Medication: Antibiotics, Immunosuppressive agents, Systemic steroids, Aminosalicylic acid...
Chemical structure analogous to that of folic acid. Prevents conversion of dihydrofolate to tetrahydrofolate by competitively ...
https://emedicine.medscape.com/article/1191261-medication
Proctitis and Anusitis Medication: Corticosteroids, 5-Aminosalicylic Acid Derivatives, Immunosuppressants, Antibiotics,...Proctitis and Anusitis Medication: Corticosteroids, 5-Aminosalicylic Acid Derivatives, Immunosuppressants, Antibiotics,...
5-Aminosalicylic Acid Derivatives. Class Summary. These agents are effective in reducing inflammatory reactions. All of the ... It forms a protective coating that acts locally to protect the gastric lining against peptic acid, pepsin, and bile salts. ... Treatment of diversion colitis by short-chain fatty acids. Prospective and double-blind study. Dis Colon Rectum. 1991 Oct. 34( ... Metabolites of the drug may decrease inflammation by blocking the production of arachidonic acid metabolites in colonic mucosa. ...
https://emedicine.medscape.com/article/192910-medication
CAS No.89-57-6,5-Aminosalicylic acid Suppliers,MSDS downloadCAS No.89-57-6,5-Aminosalicylic acid Suppliers,MSDS download
where to buy 89-57-6(5-Aminosalicylic acid).Also offer free database of 89-57-6(5-Aminosalicylic acid) including MSDS sheet( ... m-Aminosalicylic acid;Sodium 5-aminosalicylate;5-Aminosalicyclic Acid;Mesalazine5-Aminosalicylic acid;5-Aminosalicylic acid ( ... English name: 5-Aminosalicylic acid Another name:Mesalamine Synonyms:Benzoic acid, 5-amino-2-hydroxy-;Asacol (TN);Benzoic acid ... 5-Aminosalicylic acid Basic information Product Name: 5-Aminosalicylic acid Synonyms: LABOTEST-BB LT00134704;IFLAB-BB F1918- ...
https://www.lookchem.com/cas-89/89-57-6.html
Mechanism of action of 5-aminosalicylic acid and its derivatives | Clinical Science | Portland PressMechanism of action of 5-aminosalicylic acid and its derivatives | Clinical Science | Portland Press
Mechanism of action of 5-aminosalicylic acid and its derivatives A. Ireland; A. Ireland ... Acetylation of 5-aminosalicylic acid by isolated human colonic epithelial cells Clin Sci (Lond) (January,1990) ... A. Ireland, D. P. Jewell; Mechanism of action of 5-aminosalicylic acid and its derivatives. Clin Sci (Lond) 1 February 1990; 78 ... Probiotics combined with aminosalicylic acid affiliates remission of ulcerative colitis: a meta-analysis of randomized ...
https://portlandpress.com/clinsci/article-abstract/78/2/119/75149/Mechanism-of-action-of-5-aminosalicylic-acid-and?redirectedFrom=fulltext
Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis | SciencePara-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis | Science
Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis ... Folate biosynthesis is an established anti-infective target, and the antifolate para-aminosalicylic acid (PAS) was one of the ... Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis ... Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis ...
http://science.sciencemag.org/content/early/2012/10/31/science.1228980
Para-aminosalicylic acid: Indication, Dosage, Side Effect, Precaution | MIMS MalaysiaPara-aminosalicylic acid: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia
Para-aminosalicylic acid: Search drug information, interaction, images & medical diagnosis. The most comprehensive database of ... Description: Para-aminosalicylic acid (also known as aminosalicyclic acid) is bacteriostatic and active against M. tuberculosis ... Disclaimer: This information is independently developed by MIMS based on Para-aminosalicylic acid from various references and ... activity of aminosalicylic acid may be antagonised by ester-type local anaesthetics such as procaine; may enhance effect of ...
https://www.mims.com/malaysia/drug/info/para-aminosalicylic%20acid?mtype=generic
High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease - Full Text View...High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease - Full Text View...
High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohns Disease. The safety and ... Drug: 4-Aminosalicylic acid Oral granules administered as one 4 g packet three times daily for two weeks followed by one 4 g ... an approved delayed-release oral formulation of 4-aminosalicylic acid, in doses of 4 grams three times daily for 2 weeks ...
https://clinicaltrials.gov/show/NCT00417690
89-57-6 - 5-Aminosalicylic acid, 95% - 5-Amino-2-hydroxybenzoic acid - Mesalamine - B23970 - Alfa Aesar89-57-6 - 5-Aminosalicylic acid, 95% - 5-Amino-2-hydroxybenzoic acid - Mesalamine - B23970 - Alfa Aesar
5-Aminosalicylic acid is used in the preparation of gastrointestinal anti-inflammatory agents. It is a metabolite of ...
https://www.alfa.com/en/catalog/B23970/
Aminosalicylic Acid Recruiting Phase 4 Trials for Human Immunodeficiency Virus (HIV) Infections Treatment - DrugBankAminosalicylic Acid Recruiting Phase 4 Trials for Human Immunodeficiency Virus (HIV) Infections Treatment - DrugBank
Aminosalicylic Acid Recruiting Phase 4 Trials for Human Immunodeficiency Virus (HIV) Infections Treatment. Back to ...
https://www.drugbank.ca/drugs/DB00233/clinical_trials?conditions=DBCOND0035016&phase=4&purpose=treatment&status=recruiting
Improved specificity of the PABA test with p-aminosalicylic acid (PAS). | GutImproved specificity of the PABA test with p-aminosalicylic acid (PAS). | Gut
We propose simultaneous administration of p-aminosalicylic acid (PAS) in the PABA test and quantification of the urinary PABA ...
https://gut.bmj.com/content/28/4/468
Global 5-Aminosalicylic Acid Market Research Report 2018 : ReportsnReportsGlobal 5-Aminosalicylic Acid Market Research Report 2018 : ReportsnReports
In this report, the global 5-Aminosalicylic Acid market is... ... Check for Discount on Global 5-Aminosalicylic Acid Market ... 1 5-Aminosalicylic Acid Market Overview. 1.1 Product Overview and Scope of 5-Aminosalicylic Acid. 1.2 5-Aminosalicylic Acid ... Global 5-Aminosalicylic Acid Market Research Report 2018 Table of Contents. Global 5-Aminosalicylic Acid Market Research Report ... 5.2 Global 5-Aminosalicylic Acid Revenue and Market Share by Type (2013-2018). 5.3 Global 5-Aminosalicylic Acid Price by Type ( ...
http://www.reportsnreports.com/reports/1285122-global-5-aminosalicylic-acid-market-research-report-2018.html
Salicylic acidUlcerativeMesalamineFolic acidDerivativesPaserGlobal 5-AminosalicyTuberculosisSodiumGranulesDrugsDerivativeInhibitPentasaIndicationsSulfasalazineAbstractOralCycloserineGlutamicSubstancesInhibits cellMechanismRapidlyInflammatoryRenalEpithelial cellsDrugClinicalSaltsAmino acidCarcinogenesisWhite crystalline acidAcetic acidMycolic acidBenzoic acid
Salicylic acid12
  • Aminosalicylic acid can refer to any amino derivative of salicylic acid, such as: 3-Aminosalicylic acid 4-Aminosalicylic acid (para-aminosalicylic acid, PAS) 5-Aminosalicylic acid (mesalazine) 6-Aminosalicylic acid This set index page lists chemical compounds articles associated with the same name. (wikipedia.org)
  • It was rediscovered by the Swedish chemist Jörgen Lehmann upon the report that the tuberculosis bacterium avidly metabolized salicylic acid. (wikipedia.org)
  • Listing your company for AMINO SALICYLIC ACID allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo! (poulvet.com)
  • The Acetyl Para Amino Salicylic Acid is included with aminosalicylic & aminobenzoic elements. (vaikunthchemicals.in)
  • Offered high-quality Acetyl Para Amino Salicylic Acid, manufactured and supplied by Vaikunth Chemicals Pvt. (vaikunthchemicals.in)
  • Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug, antiinflammatory Sulfasalazine acts locally in the intestine through its active metabolites, sulfamide 5-aminosalicylic acid and salicylic acid, by a mechanism that is not appears inhibit cyclooxygenase and prostaglandin production and is used in. (desi.pw)
  • Topical treatment of distal ulcerative colitis with 4-amino-salicylic acid enemas. (ox.ac.uk)
  • Enemas of 4-amino-salicylic acid (4-ASA) have been compared with placebo enemas in a double-blind study for the treatment of distal ulcerative colitis of mild to moderate severity. (ox.ac.uk)
  • 5 Amino salicylic acid (5-ASA) and several structurally-related analogs were tested for inhibitory role on nitrite-induced oxidation of hemoglobin in human blood-hemolysates. (elsevier.com)
  • On the other hand, acetyl salicylic acid and salicylic acid increased the methemoglobin levels in hemolysate. (elsevier.com)
  • As acetyl salicylic acid and 5-ASA are currently being prescribed, it is worth investigating their in vivo activity in order to establish novel and hitherto unexplored clinical applications. (elsevier.com)
  • Unnikrishnan, M.K. / 5-Amino salicylic acid inhibits nitrite-induced methemoglobin formation . (elsevier.com)
Ulcerative9
  • 4-aminosalicylic acid has also been used in the treatment of inflammatory bowel disease (ulcerative colitis and Crohn's disease), but has been superseded by other drugs such as sulfasalazine and mesalazine. (wikipedia.org)
  • Sulfasalazine revisited: a meta-analysis of 5-aminosalicylic acid in the treatment of ulcerative colitis. (annals.org)
  • To evaluate the effectiveness of the new 5-aminosalicylic acid (5-ASA) delivery systems compared with sulfasalazine or placebo in patients with ulcerative colitis using meta-analysis. (annals.org)
  • To examine the effect of topical 5-aminosalicylic acid (5-ASA) enemas on the presence of six histological features of chronicity in established chronic ulcerative colitis, 123 mucosal biopsies were taken prospectively at 1-month intervals, all from the same anatomic location (10 cm), from 14 patients treated with either 5-ASA or placebo enemas. (nih.gov)
  • In ulcerative colitis (UC) 5-aminosalicylic acid (5-ASA) is recommended as primary therapy for mild to moderate disease. (uzh.ch)
  • N. Mahmud, D. O'Toole, N. O'Hare, P. J. Freyne, D. G. Weir and D. Kelleher `Evaluation of renal function following treatment with 5-aminosalicylic acid derivatives in patients with ulcerative colitis? (tcd.ie)
  • Several studies suggest inflammation as a risk factor for the development of cancer, including colorectal cancer (CRC) (1).Individuals suffering from either of the two main chronic forms of inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's Cited by: 5-Aminosalicylic acid inhibits colitis-associated but not sporadic colorectal neoplasia in a novel conditional Apc mouse model. (desi.pw)
  • Cochrane Abstracts, Evidence Central, evidence.unboundmedicine.com/evidence/view/Cochrane/432835/all/Oral_5_aminosalicylic_acid_for_induction_of_remission_in_ulcerative_colitis:_Cochrane_systematic_review. (unboundmedicine.com)
  • The efficacy of 5-aminosalicylic acid (5-ASA) as the first-line therapy for ulcerative colitis (UC) is determined by the extent of drug delivery to the inflamed region. (elsevier.com)
Mesalamine2
  • Sulfasalazine consists of one molecule of 5-aminosalicylic acid (5-ASA, mesalamine) coupled by an azo bond to one molecule of sulfapyridine. (hindawi.com)
  • 5-aminosalicylic acid A minosalicylates or 5-aminosalicylic acid (5-ASA, mesalamine) have been shown to exhibit a wide range of anti-inflammatory and immunomodu-latory properties.1 Sulfasalazine, the prototype aminosalicylate and an original "designer drug," was developed for the treatment of rheumatoid. (desi.pw)
Folic acid15
  • 4-Aminosalicylic acid is believed to work by blocking the ability of bacteria to make folic acid. (wikipedia.org)
  • Firstly, aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). (drugbank.ca)
  • The binding of para-aminobenzoic acid to pteridine synthetase acts as the first step in folic acid synthesis. (drugbank.ca)
  • Aminosalicylic acid binds pteridine synthetase with greater affinity than para-aminobenzoic acid, effectively inhibiting the synthesis of folic acid. (drugbank.ca)
  • As bacteria are unable to use external sources of folic acid, cell growth and multiplication slows. (drugbank.ca)
  • an analogue of p -aminobenzoic acid that inhibits folic acid synthesis in Mycobacterium tuberculosis, used in the treatment of tuberculosis , administered orally. (thefreedictionary.com)
  • Chemical structure analogous to that of folic acid. (medscape.com)
  • Aminosalicylic acid and salts are highly specific bacteriostatic agents that suppress growth and multiplication of Mycobacterium tuberculosis by preventing folic acid synthesis . (medpill.info)
  • Folic acid is a type of B vitamin. (medlineplus.gov)
  • This article discusses the test to measure the amount of folic acid in the blood. (medlineplus.gov)
  • Your health care provider may tell you to stop taking any drugs that may interfere with test results, including folic acid supplements. (medlineplus.gov)
  • This test is done to check for folic acid deficiency . (medlineplus.gov)
  • Folic acid helps form red blood cells and produce DNA that stores genetic codes. (medlineplus.gov)
  • Taking the right amount of folic acid before and during pregnancy helps prevent neural tube defects, such as spina bifida. (medlineplus.gov)
  • Women who are pregnant or planning to become pregnant should take at least 600 micrograms (mcg) of folic acid every day. (medlineplus.gov)
Derivatives2
  • Which medications in the drug class 5-Aminosalicylic Acid Derivatives are used in the treatment of Crohn Disease? (medscape.com)
  • The invention refers to 5-aminosalicylic acid (5-ASA) derivatives of general formula 1 ##STR1## wherein R 1 is hydrogen, glutamyl (Glu) or aspartyl (Asp) and R 2 is OH or the residue leucyl-prolyl, with the proviso that R 1 and R 2 cannot be contemporaneously hydrogen and hydroxy, respectively. (desi.pw)
Paser11
  • 4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) and sold under the brand name Paser among others, is an antibiotic primarily used to treat tuberculosis. (wikipedia.org)
  • PASER (aminosalicylic acid) granules are a delayed release granule preparation of aminosalicylic acid (p-aminosalicylic acid: 4-aminosalicylic acid) for use with other anti-tuberculosis drugs for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. (rxlist.com)
  • PASER granules are the free base of aminosalicylic acid and do NOT contain sodium or a sugar. (rxlist.com)
  • PASER (aminosalicylic acid) is indicated for the treatment of tuberculosis in combination with other active agents. (rxlist.com)
  • When PASER (aminosalicylic acid) is added to the treatment regimen in patients with proven or suspected drug resistance , it should be accompanied by at least one and preferably two other new agents to which the patient's organism is known or expected to be susceptible. (rxlist.com)
  • PASER (aminosalicylic acid) granules should be administered with other drugs to which the organism is known or expected to be susceptible. (rxlist.com)
  • Carton of 30 PASER (aminosalicylic acid) packets (NDC 49938-107-04). (rxlist.com)
  • PASER (aminosalicylic acid) granules are supplied in packets containing 4 grams of aminosalicylic acid for administration three times a day by suspension in an acidic drink or food with a pH less than 5. (rxlist.com)
  • Patients are urged to store PASER (aminosalicylic acid) in a refrigerator or freezer. (rxlist.com)
  • PASER (aminosalicylic acid) packets may be stored at room temperature for short periods of time. (rxlist.com)
  • The purpose of this 4 week study is to determine whether PASER®, an approved delayed-release oral formulation of 4-aminosalicylic acid, in doses of 4 grams three times daily for 2 weeks followed by 4 grams twice daily for 2 weeks, will resolve an acute flare of ileocecal Crohn's disease. (clinicaltrials.gov)
Global 5-Aminosalicy3
  • In this report, the global 5-Aminosalicylic Acid market is valued at USD XX million in 2017 and is expected to reach USD XX million by the end of 2025, growing at a CAGR of XX% between 2017 and 2025. (reportsnreports.com)
  • The report forecast global 5-Aminosalicylic Acid market to grow to reach xxx Million USD in 2020 with a CAGR of xx% during the period 2020-2025. (reportsinsights.com)
  • First, this report covers the present status and the future prospects of the global 5-Aminosalicylic Acid market for 2015-2025. (reportsinsights.com)
Tuberculosis10
  • The main use for 4-aminosalicylic acid is for the treatment of tuberculosis infections. (wikipedia.org)
  • In the United States, 4-aminosalicylic acid is indicated for the treatment of tuberculosis in combination with other active agents. (wikipedia.org)
  • Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. (drugbank.ca)
  • Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). (drugbank.ca)
  • There are two mechanisms responsible for aminosalicylic acid's bacteriostatic action against Mycobacterium tuberculosis . (drugbank.ca)
  • Secondly, aminosalicylic acid may inhibit the synthesis of the cell wall component, mycobactin, thus reducing iron uptake by M. tuberculosis . (drugbank.ca)
  • Aminosalicylic acid is an anti tubercular that is FDA approved for the treatment of tuberculosis . (wikidoc.org)
  • How does p-aminosalicylic acid treat tuberculosis? (sharecare.com)
  • P-aminosalicylic acid is an antibiotic medication that works by killing or slowing down the bacteria that cause tuberculosis. (sharecare.com)
  • Para-aminosalicylic acid (also known as aminosalicyclic acid) is bacteriostatic and active against M. tuberculosis . (mims.com)
Sodium2
  • The sodium salt of the drug is better tolerated than the free acid. (drugbank.ca)
  • sodium form more rapidly absorbed than the acid. (medpill.info)
Granules2
  • PASAR granules are supplied as off-white tan colored granules with an average diameter of 1.5 mm and an average content of 60% aminosalicylic acid by weight. (rxlist.com)
  • granules have an acid resistant coating that dissolves within a minute at neutral pH. (mims.com)
Drugs4
  • You must check to make sure that it is safe for you to take aminosalicylic acid with all of your drugs and health problems. (drugs.com)
  • Extensively drug-resistant TB (XDR TB) was initially defined as an MDR isolate that was resistant to at least 3 of the 6 main classes of second-line drugs: aminoglycosides, polypeptides, fluoroquinolones, thioamides, cycloserine, and para-aminosalicylic acid (4). (thefreedictionary.com)
  • Novel carrier-linked azo prodrugs of 4 and 5-aminosalicylic acids (4-ASA and 5-ASA respectively) using the same drugs as carriers in different permutations and combinations were designed for targeting colon affected with inflammatory bowel disease (IBD). (eurekaselect.com)
  • Decade of experience as well as adequacy of resources has supported and enhanced our capabilities to bring high grade Bulk Drugs, Aminosalicylic Acid as well as Drug Intermediates. (vaikunthchemicals.in)
Derivative2
  • 2-Hydroxy-5-diazonium benzoic acid (diazonium derivative) and NO were detected as products of the reaction. (uchile.cl)
  • Saccharin is a derivative of this acid. (tabers.com)
Inhibit1
  • Corticosteroids inhibit formation of arachidonic acid from phospholipids when cell membranes are damaged. (thefreedictionary.com)
Pentasa1
  • The influence of intestinal transit time on the release of 5‐ aminosalicylic acid (5‐ASA) from a peroral, slow‐release preparation (Pentasa) was studied at steady state in seven healthy volunteers. (desi.pw)
Indications1
  • There is limited information regarding FDA-labeled indications and dosage of Aminosalicylic acid in pediatric patients. (wikidoc.org)
Sulfasalazine1
  • Sulfasalazine was toxic for peripheral blood mononuclear cells, whereas 5-aminosalicylic acid and sulfapyridine were not toxic. (desi.pw)
Abstract2
  • in revised form: 22 April 2012 / Accepted: 22 May 2012 / Published: 24 May 2012 Abstract: In this study, solution enhanced dispersion by supercritical fluids (SEDS) technique was applied for the preparation of 5-aminosalicylic acid (5-ASA) loaded Eudragit S100 (EU S100) nanoparticles. (sciencedocbox.com)
  • abstract = "Pre-treatment with 5-aminosalicylic acid (5-ASA) significantly reduced sperm-shape abnormalities in endosulfan-treated rats. (elsevier.com)
Oral3
  • The packets contain 4 grams of aminosalicylic acid for oral administration three times a day by sprinkling an apple sauce or yogurt to be eaten without chewing. (rxlist.com)
  • BACKGROUND: A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5-aminosalicylic acid (5-ASA). (tcd.ie)
  • Randomised controlled trials assessing the efficacy of oral 5-aminosalicylic acid (5-ASA) agents for maintenance of medically-induced remission in Crohn's disease have produced conflicting results. (uclan.ac.uk)
Cycloserine1
  • Routine DST for pyrazinamide, kanamycin, cycloserine, and para-aminosalicylic acid was not performed. (thefreedictionary.com)
Glutamic1
Substances1
  • We could show that the flavonoids (−)-epicatechin, (+)-catechin hydrate, and rutin trihydrate as well as vitamin C and the pharmacological substances N -acetyl-L-cysteine and 5-aminosalicylic acid inhibited PMA induced ROS production and NET formation. (hindawi.com)
Inhibits cell1
  • this binding inhibits cell wall mycolic acid biosynthesis. (cdc.gov)
Mechanism1
  • The mechanism by which 5-aminosalicylic acid (5-ASA) reduces mucosal injury in colitis is undefined. (utmb.edu)
Rapidly1
  • the protective acid-resistant outer coating is rapidly dissolved in neutral media so a mildly acidic food such as orange, apple or tomato juice, yogurt or apple sauce should be used. (rxlist.com)
Inflammatory4
  • 5-Aminosalicylic acid is used in the preparation of gastrointestinal anti-inflammatory agents. (alfa.com)
  • Dhaneshwar Suneela, Vadnerkar Gaurav and Rai Himanshu, "Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for Inflammatory Bowel Disease: A Colon-Targeted Approach", Inflammation & Allergy - Drug Targets (Discontinued) (2013) 12: 328. (eurekaselect.com)
  • 5-Aminosalicylic acid is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease. (abmole.com)
  • 5-aminosalicylic acid (5-ASA), a typical anti-inflammatory drug, has been used for over 30 years in the treatment of IBD. (sciencedocbox.com)
Renal3
  • The half life of free aminosalicylic acid in renal disease is 30.8 minutes in comparison to 26.4 minutes in normal volunteers. (wikidoc.org)
  • Patients with end stage renal disease should not receive aminosalicylic acid . (wikidoc.org)
  • The acid is a known carcinogen, and its use has been associated with and may cause end-stage renal disease and cancers of the urinary tract that may occur many years after usage has stopped. (thefreedictionary.com)
Epithelial cells1
  • 5-aminosalicylic acid inhibits iNOS transcription in human intestinal epithelial cells. (utmb.edu)
Drug6
  • The drug should be taken with acid food or drink (orange, apple or tomato juice). (wikipedia.org)
  • The U.S. Food and Drug Administration (FDA) assigned 4-aminosalicylic acid to pregnancy category C, indicating that it is not known whether it will harm an unborn baby. (wikipedia.org)
  • 4-aminosalicylic acid has been shown to be a pro-drug and it is incorporated into the folate pathway by dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate a hydroxyl dihydrofolate antimetabolite, which in turn inhibits dihydrofolate reductase (DHFR) enzymatic activity. (wikipedia.org)
  • The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. (drugbank.ca)
  • Metabolites of the drug may decrease inflammation by blocking the production of arachidonic acid metabolites in colonic mucosa. (medscape.com)
  • Folate biosynthesis is an established anti-infective target, and the antifolate para -aminosalicylic acid (PAS) was one of the first anti-infectives introduced into clinical practice based on target-based drug discovery. (sciencemag.org)
Clinical1
  • Aminosalicylic acid was introduced to clinical use in 1944. (wikipedia.org)
Salts1
  • Any of the complex acids that occur as salts in bile, e.g., cholic, glycocholic, and taurocholic acids. (tabers.com)
Amino acid5
  • A single receptor on natural killer cells recognizes an amino acid sequence conserved across Zika, dengue, and related pathogens. (the-scientist.com)
  • C 4 H 7 NO 4 , a nonessential amino acid that is a product of pancreatic digestion. (thefreedictionary.com)
  • The activity of RMP on isolates with rpoB mutations depends on both the mutation position and the type of amino acid change. (cdc.gov)
  • Within fabG1 , the silent/synonymous mutation (i.e., nucleotide change but no corresponding change in amino acid) Leu203Leu has been found to confer INH resistance through the formation of an alternative promoter, thereby increasing the transcriptional levels of inhA [ 11 ]. (cdc.gov)
  • C 4 H 7 NO 4 , a nonessential amino acid. (tabers.com)
Carcinogenesis1
  • 4 edition of 5-Aminosalicylic acid and colorectal carcinogenesis found in the catalog. (desi.pw)
White crystalline acid2
  • C 7 H 6 O 2 , a white crystalline acid having a slight odor. (thefreedictionary.com)
  • H 3 BO 3 , a white crystalline acid that in water forms a very weak acid solution poisonous to plants and animals. (tabers.com)
Acetic acid1
  • Glacial (highly purified) acetic acid contains at least 99.5% acetic acid by weight. (thefreedictionary.com)
Mycolic acid2
  • The fabG1 (also known as mab A) gene, like inhA , is involved in mycolic acid biosynthesis and at least one mutation in this region has been associated with low-level INH resistance [ 10 , 11 ]. (cdc.gov)
  • Hydrazides / mycolic acid synth. (wikipedia.org)
Benzoic acid1
  • Benzoic acid showed marginal activity at lower concentrations. (elsevier.com)
Mesalamine: Side Effects, Dosages, Treatment, Interactions, Warnings
Mesalamine: Side Effects, Dosages, Treatment, Interactions, Warnings (rxlist.com)
4-aminosalicylic acid - Substance Information - ECHA
4-aminosalicylic acid - Substance Information - ECHA (echa.europa.eu)
Current and future treatments for irritable bowel syndrome associated with diarrhea - Mayo Clinic
Current and future treatments for irritable bowel syndrome associated with diarrhea - Mayo Clinic (mayoclinic.org)
DL-Adrenalin|L(-)-Epinephrine|5-Azacytidine|N4-Acetylcytosine|5-Aminosalicylic acid|--Xinxiang Tianf
DL-Adrenalin|L(-)-Epinephrine|5-Azacytidine|N4-Acetylcytosine|5-Aminosalicylic acid|--Xinxiang Tianf (mbtskobutikk.org)
Salicylic Acid Price, Salicylic Acid Price Suppliers and Manufacturers at Alibaba.com
Salicylic Acid Price, Salicylic Acid Price Suppliers and Manufacturers at Alibaba.com (alibaba.com)
Treatment of Tuberculosis American Thoracic Society, CDC, and Infectious Diseases Society of America
Treatment of Tuberculosis American Thoracic Society, CDC, and Infectious Diseases Society of America (cdc.gov)
Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps
Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps (hindawi.com)
Vitamin B12 level: MedlinePlus Medical Encyclopedia
Vitamin B12 level: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Course Content - #94552: Tuberculosis: An Update - NetCE
Course Content - #94552: Tuberculosis: An Update - NetCE (netce.com)
Buy Pentasa Medication 500mg Tablet Online From Canadian Pharmacy
Buy Pentasa Medication 500mg Tablet Online From Canadian Pharmacy (canadapharmacy.com)
Cyanocobalamin Injection: MedlinePlus Drug Information
Cyanocobalamin Injection: MedlinePlus Drug Information (medlineplus.gov)
A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to...
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Digitek Advanced Patient Information - Drugs.com
Digitek Advanced Patient Information - Drugs.com (drugs.com)
Aminosalicylate calcium - DrugBank
Aminosalicylate calcium - DrugBank (drugbank.ca)
Therapeutic Retention Enemas: An Underutilized Modality for UC - Naturopathic Doctor News and Review
Therapeutic Retention Enemas: An Underutilized Modality for UC - Naturopathic Doctor News and Review (ndnr.com)
Https://www.medicalnewstoday.com/articles/317863.php
Https://www.medicalnewstoday.com/articles/317863.php (medicalnewstoday.com)
IJMS | Free Full-Text | Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the...
IJMS | Free Full-Text | Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the... (mdpi.com)
Tuberculosis (TB) Treatment & Management: Approach Considerations, Treatment During Pregnancy, Treatment in Children
Tuberculosis (TB) Treatment & Management: Approach Considerations, Treatment During Pregnancy, Treatment in Children (emedicine.medscape.com)
Nitrate/Nitrite Toxicity: Clinical Assessment - Evaluation | Environmental Medicine | ATSDR
Nitrate/Nitrite Toxicity: Clinical Assessment - Evaluation | Environmental Medicine | ATSDR (atsdr.cdc.gov)
Tuberculosis: New Faces of an Old Disease | Doctors Without Borders - USA
Tuberculosis: New Faces of an Old Disease | Doctors Without Borders - USA (doctorswithoutborders.org)
Acid | Taber's Medical Dictionary
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Appendix Figure - Clonal Expansion of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, Japan - Volume 16,...
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