Aminosalicylic Acids: A group of 2-hydroxybenzoic acids that can be substituted by amino groups at any of the 3-, 4-, 5-, or 6-positions.Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)Aminosalicylic Acid: An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.Sulfapyridine: Antibacterial, potentially toxic, used to treat certain skin diseases.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.Enema: A solution or compound that is introduced into the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.Phenylhydrazines: Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)Inflammatory Bowel Diseases: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.Proctitis: INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Suppositories: Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)Gastrointestinal Agents: Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.6-Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.Sulfanilamides: Compounds based on 4-aminobenzenesulfonamide. The '-anil-' part of the name refers to aniline.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Administration, Rectal: The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)Amylose: An unbranched glucan in starch.Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Anti-Ulcer Agents: Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Adrenal Cortex HormonesDouble-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Patient Compliance: Voluntary cooperation of the patient in following a prescribed regimen.Intestines: The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.Ileum: The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Intermediate Filament Proteins: Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.Manganese Poisoning: Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)Antitubercular Agents: Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.Anacardium: A plant genus of the family ANACARDIACEAE. This is the source of the familiar cashew nuts, which are heat treated to remove the irritant toxin. Cashew nut shell liquid (frequently abbreviated as CNSL) is a major source of alkenyl phenolic compounds, especially ANACARDIC ACIDS, cardol, and cardanol.Allergy and Immunology: A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.Kidney Pelvis: The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.Anal Canal: The terminal segment of the LARGE INTESTINE, beginning from the ampulla of the RECTUM and ending at the anus.

The systemic load and efficient delivery of active 5-aminosalicylic acid in patients with ulcerative colitis on treatment with olsalazine or mesalazine. (1/215)

BACKGROUND: There have been reports of nephrotoxic reactions in patients with ulcerative colitis treated with 5-aminosalicylic acid (5-ASA) preparations. AIM: To compare the efficacy in delivery of active 5-ASA to the colon and the systemic load as the basis for potential long-term toxicity during treatment with olsalazine or mesalazine in patients with ulcerative colitis in remission. PATIENTS AND METHODS: Fifteen patients with ulcerative colitis were treated with olsalazine or mesalazine, each for 7 days in an open, randomized, crossover design study. 5-ASA and acetyl-5-ASA (Ac-5-ASA) in plasma and urine were measured by high performance liquid chromatography. RESULTS: The plasma concentration of 5-ASA was 1.2 +/- 0.1 micromol/L (mean +/- S.E.M.) for olsalazine and 8.0 +/- 1.9 micromol/L for mesalazine, while the plasma concentration of Ac-5-ASA was 2.8 +/- 0.2 micromol/L for olsalazine and 10.8 +/- 1.6 micromol/L for mesalazine. The amount of 5-ASA excreted in the urine was 68 +/- 30 micromol/24 h for olsalazine and 593 +/- 164 micromol/24 h for mesalazine. The amount of Ac-5-ASA in the urine was 1260 +/- 102 micromol/24 h for olsalazine and 3223 +/- 229 micromol/24 h for mesalazine. The urinary recovery of total 5-ASA plus Ac-5-ASA (as a percentage of the given dose) was 23 +/- 2.1% for olsalazine and 39 +/- 3.6% for mesalazine. The ratio between the plasma concentrations of mesalazine and olsalazine differed significantly both for 5-ASA (5.1) and Ac-5-ASA (3.6); for 5-ASA (9. 9) and Ac-5-ASA (2.6) in urine, and for the urinary recovery of total 5-ASA plus Ac-5-ASA (1.7). Moreover, in the mesalazine group there was a large variation in the individual plasma concentrations of 5-ASA and Ac-5-ASA, with maximal values 5-6-fold higher than that in the olsalazine group. CONCLUSION: The systemic load of active 5-ASA is significantly higher for mesalazine than for olsalazine, when based on the dosages given and when calculated on an equimolar basis. Some of the patients in the mesalazine group showed unexpected high levels of plasma and urinary 5-ASA concentrations, a finding which may have long-term safety implications.  (+info)

Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies. (2/215)

BACKGROUND: The therapeutic efficacy of 5-aminosalicylic acid in inflammatory bowel disease may be related to its antioxidant properties. AIM: To compare in vitro the antioxidant effects of conventional drugs (5-aminosalicylic acid, corticosteroids, metronidazole), with new aminosalicylates (4-aminosalicylic acid, balsalazide) and other potential therapies (ascorbate, N-acetylcysteine, glutathione, verapamil). METHODS: Compounds were assessed for efficacy in reducing the in vitro production of reactive oxygen species by cell-free systems (using xanthine/xanthine oxidase, with or without myeloperoxidase) and by colorectal biopsies from patients with ulcerative colitis using luminol-amplified chemiluminescence. RESULTS: 5-aminosalicylic acid and balsalazide were more potent antioxidants than 4-aminosalicylic acid or N-acetyl-5-aminosalicylic acid in cell-free systems. 5-aminosalicylic acid (20 mM) and balsalazide (20 mM) inhibited rectal biopsy chemiluminescence by 93% and 100%, respectively, compared with only 59% inhibition by 4-aminosalicylic acid (20 mM). Hydrocortisone, metronidazole and verapamil had no significant effect on chemiluminescence in any system. Ascorbate (20 mM) inhibited chemiluminescence by 100% in cell-free systems and by 60% in rectal biopsies. N-acetyl cysteine (10 mM), and both oxidized and reduced glutathione (10 mM), completely inhibited chemiluminescence in cell-free systems, but not with rectal biopsies. CONCLUSIONS: The antioxidant effects of compounds varies between cell-free systems and inflamed colorectal biopsies. The effect of drugs on the chemiluminescence produced by these two assay systems is useful for screening potentially new antioxidant treatments for inflammatory bowel disease. Ascorbate seems worth further study as a novel therapy.  (+info)

Review article: the efficacy of infliximab in Crohn's disease--healing of fistulae. (3/215)

In the management of fistulae, the current therapeutic approach is the use of a combination of antibiotics and/or a combination of immunomodulatory agents. However, clinicians treating patients with fistulae, particularly those with fistulizing Crohn's disease, have little data from controlled clinical trials of these pharmacologic agents or regimens to substantiate their use in treating this complication. Therapy with the anti-tumour necrosis factor-alpha antibody, infliximab, has shown promise in treating patients with Crohn's disease and those with the disease complicated by fistulae. A recent clinical trial was designed specifically to evaluate infliximab in the treatment of fistulizing Crohn's disease. Study results demonstrated infliximab to be the first therapeutic agent to show statistical efficacy in fistulae closure in a placebo-controlled trial. Therapy with the chimeric monoclonal antibody was characterized by a rapid onset of closure and a lasting benefit of action. Two patient cases from the clinical trial are presented to exemplify the dramatic effectiveness of this novel therapeutic approach in modulating the immune response of patients with this debilitating complication of Crohn's disease.  (+info)

Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat. (4/215)

The present study was undertaken to investigate the intestinal anti-inflammatory effects of UR-12746 on the acute and chronic stages of a trinitrobenzene sulphonic acid (TNBS) experimental model of inflammatory bowel disease (IBD) in the rat. UR-12746 is a novel, locally-acting compound which combines, through an azo bond, 5-aminosalicylic (5-ASA) and UR-12715, a potent platelet activating factor (PAF)-antagonist. UR-12746 oral pretreatment of colitic rats (50 and 100 mg kg(-1)) reduced acute colonic damage when evaluated 2 days after colonic insult. Postreatment for 4 weeks with UR-12746 (50 and 100 mg kg(-1)) resulted in a faster recovery of the damaged colonic mucosa, which was macroscopically significant from the third week. The intestinal anti-inflammatory effect of UR-12746 was associated with a decrease in leukocyte infiltration in the colonic mucosa, which was evidenced both biochemically, by a reduction in myeloperoxidase activity, and histologically, by a lower leukocyte count after morphometric analysis. This effect was higher than that seen with sulphasalazine, when assayed at the same doses and in the same experimental conditions. Several mechanisms can be involved in the beneficial effects showed by UR-12746: inhibition of leukotriene B(4) synthesis in the inflamed colon, improvement of the altered colonic oxidative status, and reduction of colonic interleukin-1beta production. The results suggest that the intestinal anti-inflammatory activity of UR-12746 can be attributed to the additive effects exerted by 5-ASA and UR-12715, the PAF antagonist compound, that are released in the colonic lumen after reduction of the azo bond by the intestinal bacteria.  (+info)

Minimal renal dysfunction in inflammatory bowel disease is related to disease activity but not to 5-ASA use. (5/215)

BACKGROUND: Conflicting data exist about proteinuria in inflammatory bowel diseases. It is still unclear whether the occurrence of proteinuria in inflammatory bowel disease patients is an extra-intestinal manifestation of disease or the result of adverse effects to medication, especially to aminosalicylates (ASA). METHODS: A total of 95 patients (51 with Crohn's disease and 44 with ulcerative colitis) were enrolled in the study. Disease activity was assessed by Crohn's Disease Activity Index (CDAI) or the Truelove index, respectively. Urine was collected over 24 h and protein excretion of specific marker proteins for tubular (alpha 1-microglobulin-alpha 1-MG) and glomerular (albumin-Alb, Immunoglobulin G-IgG) dysfunction was measured using a highly sensitive immunoluminometric assay. RESULTS: Out of 51 Crohn's disease patients, 20 showed elevated urinary alpha 1-MG. The amount of alpha 1-MGuria was strongly correlated to the CDAI (r=0.6, P < 0.001). Only four Crohn's disease patients showed slightly elevated values for glomerular proteins in urine. Similar results were obtained for ulcerative colitis: whereas only two ulcerative colitis patients showed albuminuria, tubular proteinuria was detected in 28 out of 44 ulcerative colitis patients. Proteinuria was strongly dependent on disease activity (P < 0.01) but was not related to ASA treatment. CONCLUSIONS: Proteinuria of tubular marker proteins occurs in the majority of inflammatory bowel disease patients and is related to disease activity rather than to ASA treatment. Tubular proteinuria seems to reflect a renal extra-intestinal manifestation of inflammatory bowel disease and may serve as a new relevant marker of disease activity.  (+info)

NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines. (6/215)

The activation of a self-amplifying cascade of caspases, of which caspase-8 is the apical protease, mediates Fas-, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-, and TNF-alpha-induced apoptosis in colon cell lines. Nitric oxide (NO) protects from apoptosis induced by Fas and TNF-alpha. We examined whether NCX-456, an NO-releasing derivative of mesalamine, protects colon epithelial cells from cytokine-induced apoptosis. Caco-2 and HT-29 cell lines express death factor receptors and are driven to apoptosis in response to incubation with Fas-agonistic antibody, TNF-alpha/interferon-gamma, and TRAIL. The two novel observations reported here are that 1) cotreatment of cells with NCX-456, but not mesalamine, resulted in concentration-dependent protection against death factor-induced apoptosis and inhibition of caspase activity, and 2) exposure to dithiothreitol, an agent that effectively removes NO from thiol groups, resulted in a 70% recovery of caspase activity, which is consistent with S-nitrosation as a major mechanism for caspase inactivation. These data suggest that caspase S-nitrosation represents a mechanism for protection of colonic mucosal epithelial cells from death factor-induced death.  (+info)

Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study. (7/215)

BACKGROUND AND AIMS: The benefit of 5-aminosalicylic acid therapy for maintenance of remission in Crohn's disease is controversial. The primary aim of this study was to evaluate the prophylactic properties of olsalazine in comparison with placebo for maintenance of remission in quiescent Crohn's colitis and/or ileocolitis. METHODS: In this randomised, double blind, parallel group study of olsalazine versus placebo, 328 patients with quiescent Crohn's colitis and/or ileocolitis were recruited. Treatment consisted of olsalazine 2.0 g daily or placebo for 52 weeks. The primary end point of efficacy was relapse, as defined by the Crohn's disease activity index (CDAI) and by clinical relapse. Laboratory and clinical disease activity indicators were also measured. Safety analysis consisted of documentation of adverse events and laboratory values. RESULTS: No differences in the frequency of termination due to relapse or time to termination due to relapse were noted between the two treatment groups (olsalazine 48.5% v placebo 45%) for either colitis or ileocolitis. The failure rate, defined as not completing the study, was significantly higher in olsalazine treated patients compared with placebo treated patients for the overall population (colitis and/or ileocolitis: olsalazine 65.4% v 53.9%; p=0.038). Similar failure rates were seen for patients with colitis. A significantly higher percentage of olsalazine treated patients experienced adverse gastrointestinal events. Drug attributed adverse events were reported more frequently in the olsalazine treated group with gastrointestinal symptoms being causally related to olsalazine treatment (olsalazine 40.7% v placebo 26.9%; p=0.010). Back pain was reported significantly more often by the placebo treated group. However, serious medical events did not differ between the two groups. Adverse events led to more early withdrawals in the olsalazine treated group than in the placebo treated group; thus average time in the study for patients in the olsalazine treatment group was significantly shorter than that of patients in the placebo group. CONCLUSIONS: Patients treated with olsalazine were more likely to terminate their participation in the trial than those taking placebo. This difference was not related to relapse of disease, as measured by CDAI and clinical measures, but rather was due to the development of intolerable adverse medical events of a non-serious nature related to the gastrointestinal tract. The gastrointestinal related events in the olsalazine treated group may be due to the difference in gastrointestinal status at baseline which favoured the placebo treatment group.  (+info)

Review article: balsalazide therapy in ulcerative colitis. (8/215)

Balsalazide is a 5-aminosalicylic acid (mesalazine) pro-drug which has an inert carrier molecule instead of the sulfapyridine moiety of sulfasalazine. It is designed to deliver 5-aminosalicylic acid to the colonic mucosa without the sulfapyridine-associated side-effects encountered with sulfasalazine. Several studies have confirmed the efficacy and patient tolerance of balsalazide. When compared to mesalazine at equivalent doses, it induced symptomatic and complete remission of acute ulcerative colitis in a greater proportion of patients. In particular, patients with resistant left-sided disease were shown to have a higher probability of achieving remission. Balsalazide was beneficial in patients with troublesome nocturnal symptoms. It has a similar efficacy in maintaining remission when compared to sulfasalazine and mesalazine. The advantage of balsalazide over other 5-aminosalicylic acid compounds is its superior patient tolerability with minimal side-effects.  (+info)

Title:Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for Inflammatory Bowel Disease: A Colon-Targeted Approach. VOLUME: 12 ISSUE: 5. Author(s):Dhaneshwar Suneela, Vadnerkar Gaurav and Rai Himanshu. Affiliation:Department of Pharmaceutical Chemistry, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune-411038, Maharashtra, India.. Keywords:4-Aminosalicylic acid, 5-Aminosalicylic acid, azo prodrug, colon-targeting, inflammatory bowel disease, sulfasalazine.. Abstract:Novel carrier-linked azo prodrugs of 4 and 5-aminosalicylic acids (4-ASA and 5-ASA respectively) using the same drugs as carriers in different permutations and combinations were designed for targeting colon affected with inflammatory bowel disease (IBD). Improved hydrophilic nature of the prodrugs assisted in minimizing their absorption in upper GIT and efficient delivery of the active drugs to colon as evidenced from their stability in aqueous ...
[123 Pages Report] Check for Discount on Global 5-Aminosalicylic Acid Market Research Report 2018 report by QYResearch Group. In this report, the global 5-Aminosalicylic Acid market is...
0076]There has been surprisingly little work involving 4-ASA in IBD, particularly in the United States. However, in 1984, a 4-aminosalicylic acid rectal preparation was shown to have equal activity to the 5-ASA preparation (Campieri A, Lanfranchi G A, Bertoni F, Brignola C, Bazzocchi G, Minguzzi M R, and Labo G. A Double-Blind Clinical Trial to Compare the Effects of 4-Aminosalicylic Acid to 5-Aminosalicylic Acid in Topical Treatment of Ulcerative Colitis. Digestion. 1984; 29:204-208). 4-ASA enemas were shown to be more effective in inducing clinical and sigmoidoscopic improvement than placebo at either 1 or 2 gram doses for distal ulcerative colitis (Selby W S, Bennett M K, Jewell D P. Topical treatment of distal ulcerative colitis with 4-amino-salicylic acid enemas. Digestion 1984; 29:231-234). Subsequently, a 2 gram nightly 4-ASA retention enema was shown to result in significant improvement in clinical, sigmoidoscopic and histologic variables after 8 weeks in active left-sided ulcerative ...
Learn about Paser (Aminosalicylic Acid) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Easy to read patient leaflet for Aminosalicylic Acid. Includes indications, proper use, special instructions, precautions, and possible side effects.
Listing your company for AMINO SALICYLIC ACID allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo!, MSN etc ...
Sodium 4-aminosalicylate dihydrate 6018-19-5 NMR spectrum, Sodium 4-aminosalicylate dihydrate H-NMR spectral analysis, Sodium 4-aminosalicylate dihydrate C-NMR spectral analysis ect.
Randomized controlled trials were included if they compared oral 5-ASA with sulfasalazine or placebo for a minimum of 4 weeks for acute therapy and 6 months for maintenance therapy in patients with mild-to-moderate ulcerative colitis. Of 59 trials identified, 27 met the inclusion criteria: 16 for active treatment and 11 for remission maintenance ...
Inflammatory bowel diseases are associated with increased risk of developing colitis‐associated colorectal cancer (CAC). Epidemiological data show that the consumption of ω‐3Cited by:
Patients with an evidence of or suspected abdominal abscess 2. Patients with a history of subtotal or total colectomy 3. Patients who have had a resection of the small intestine in at least 3 locations or have a diagnosis of short bowel syndrome 4. Patients with ileostomy,colostomy,or internal fistula, or severe intestinal stenosis 5. Patients who started 5-aminosalicylic acid oral drug or probiotics treatment, antimicrobials to treat Crohns disease, or 30 mg/day or less of oral corticosteroids within 13 days before initiation of study drug administration. If these drugs were used within 14 days before initiation of study drug administration, the dosage must have been changed or their use discontinued within 13 days before the initiation of study drug administration 6. Patients who have received 5-aminosalicylic acid or corticosteroid enemas/suppositories, intravenous corticosteroid injections, or more than 30 mg/day of oral corticosteroids, medications for diarrhea-predominant irritable bowel ...
Crohns disease involving predominantly the ileum and/or cecum. The diagnosis must have been established by radiography, endoscopy and/or biopsy (at least 2 of the 3 modalities) with at least one confirmatory test having been performed no more than 36 months before entry. The diagnosis must have been confirmed by at least one gastroenterologist ...
Patients with UC chronically consume 5-ASA to reduce the frequency and severity of clinical recurrence. In spite of treatment, the clinical course of the disease is extremely variable, ranging from periods of prolonged remission to frequent episodes of relapse. Since one possible explanation for the high recurrence rate could be a poor response to treatment, a higher dosage of 5-ASA has been used to provide additional therapeutic benefit to patients. Clinical trials, however, failed to demonstrate a clear cut dose-response relationship for 5-ASA.12-16 26 27 We have demonstrated an inverse relationship between mucosal concentrations of 5-ASA and UC disease activity-that is, in the same part of the intestinal tract, the higher the drug concentration, the lower the endoscopic and histological scores. Moreover, mucosal concentrations of 5-ASA were inversely correlated with mucosal levels of sIL-2R, a marker of mucosal inflammation.. In vitro studies have demonstrated that 5-ASA inhibits the activity ...
Methods The influence of 5-ASA on mTOR signalling was examined in a panel of colorectal cancer cell lines. The effects of 5-ASA on the pathways that control mTOR activity were studied in detail in two different colorectal cancer cell lines, using western blot, siRNA, a phospholipase D (PLD) activity assay, proliferation assays and cell cycle analysis. The phosphorylation status of mTOR and its downstream target, ribosomal protein S6, was studied in colorectal cancers before and after topical 5-ASA treatment.. ...
Xinxiang Tianfeng Fine Chemical Co., Ltd. engaging in the research, development, production and marketing of fine chemical products, pharmaceutical raw materials and its intermediate. The cooperation project also includes synthesis of compounds, and improvement of compound production technique. Tianfeng owns a set of perfect inspection equipment and test equipment, and the production system is in compliance with GMP Quality Management Model.
Xinxiang Tianfeng Fine Chemical Co., Ltd. engaging in the research, development, production and marketing of fine chemical products, pharmaceutical raw materials and its intermediate. The cooperation project also includes synthesis of compounds, and improvement of compound production technique. Tianfeng owns a set of perfect inspection equipment and test equipment, and the production system is in compliance with GMP Quality Management Model.
The invention relates to novel substituted aminosalicylamides, to a plurality of processes for their preparation and to their use as fungicides, and also to novel intermediates and to a plurality of processes for their preparation.
Calcium (aminosalicylate de) is a medicine available in a number of countries worldwide. A list of US medications equivalent to Calcium (aminosalicylate de) is available on the Drugs.com website.
Dipentum (olsalazine) is used to treat ulcerative colitis (also known as Inflammatory bowel disease). Learn More About Dipentun Here!
aminosalicylic acid (5-ASA) - a type of drug used to reduce inflammation in inflammatory bowel disease including balsalazide, mesalazine, oslalazine and sulphasalazine anaemia - reduced number of red blood cells which carry oxygen around the body often causing fatigue due to poor intake or absorption of vitamins and iron anal fissure - a crack or…
Dipentum (Olsalazine) is given to patients suffering from ulcerative colitis. This medication is considered effective at treating the symptoms this condition can cause, such as inflammation of the bowel, pain in the stomach, diarrhoea, bleeding of the rectum and other tissue damage.
Information about the ulcerative colitis drug olsalazine (Dipentum), including side effects, dosage, drug interactions, and pregnancy safety.
Mesasal: 5-aminosalicylic acid (5-ASA or mesalamine) belongs to the group of medications known as anti-inflammatories. It is used to treat mild to moderate ulcerative colitis and mild to moderate Crohns disease. 5-ASA acts by reducing inflammation in the bowel.
TY - JOUR. T1 - Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism. AU - De Boer, Nanne K.H.. AU - Wong, Dennis R.. AU - Jharap, Bindia. AU - De Graaf, Peer. AU - Hooymans, Piet M.. AU - Mulder, Chris J.J.. AU - Rijmen, Frank. AU - Engels, Leopold G.J.B.. AU - Van Bodegraven, Adriaan A.. PY - 2007/12/1. Y1 - 2007/12/1. N2 - INTRODUCTION: Studies indicated that 5-aminosalicylates (5-ASA) may influence the metabolism of thiopurines; however, conclusions were restricted as a result of number of patients or study design. AIM: To determine the influence of 5-ASA on thiopurine metabolism, we performed a prospective multicenter pharmacokinetic interaction study of two different 5-ASA dosages (2 g daily followed by 4 g daily) in 26 inflammatory bowel disease (IBD) patients during steady-state AZA or 6-MP therapy. RESULTS: The 4-wk coadministration of 2 g 5-ASA daily, followed by a 4-wk period of 4 g 5-ASA daily, led to a statistical significant increase of 40% (absolute 84 pmol/8 × ...
poly (methacrylic acid-co-ethyleneglycol monomethoacrylate-co-methacryloyloxyethyl 5-amino salicylate): copolymer that, upon hydrolysis, releases 5-aminosalicylic acid
Markava E.; Gailīte V.; Matisova G.; Freimanis J.; Gerca L.; Muzikante I.; Rutkis M.; Tevosov A.A. Amphiphilic N-acyl-derivatives of azobenzene based on the 4-aminobenzoic and 5-aminosalicylic acids. Mol. Cryst. Liq. Cryst. 1995, 5(3), 215-222 ...
I have steadily been reducing carbs since the beginning of the year. Over the past month I have kept them to to about 25g daily (40g including fiber).
An aqueous solution of 5-aminosalicylic acid (5-ASA) and a nontoxic alkali, alkali metal or alkaline earth metal salt of 5-aminosalicylic acid having a pH of 3-5 is disclosed. The sole buffer in the solution is that intrinsically formed by 5-aminosalicylic acid and its alkali, alkali metal or alkaline earth metal salt. The solutions preferably also contain an antioxidant and a metal complexing agent. In preferrred practice, the 5-ASA salt is formed in situ by addition of an alkali, alkali metal or alkaline earth metal hydroxide to a solution of 5-ASA. The solution is stable and does not significantly discolor due to 5-ASA decomposition for extended periods of time.
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Inflammation of the mucosal lining of the rectum is defined as proctitis, whereas anusitis is simply inflammation of the anal canal. Inflammation in these areas can cause symptoms, such as itching, burning, rectal bleeding, pelvic pressure, and foul-smelling discharge.
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohns disease.[2] It is generally used for mildly to moderately severe disease.[2] It is taken by mouth or rectally.[2] The formulations which are taken by mouth appear to be similarly effective.[3] Common side effects include headache, nausea, abdominal pain, and fever.[2] Serious side effects may include pericarditis, liver problems, and kidney problems.[2][3] Use in pregnancy and breastfeeding appears safe.[3] In people with a sulfa allergy certain formulations may result in problems.[2] Mesalazine is an aminosalicylate and anti-inflammatory.[2][3] It works by direct contact with the intestines.[2] Mesalazine was approved for medical use in the United States in 1987.[2][4] It is available as a generic medication and sold under many brand names worldwide.[5][2] A month supply in the United Kingdom costs the NHS about £43 as of ...
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Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is an aminosalicylate anti-inflammatory drug[2] used to treat inflammatory bowel disease, including ulcerative colitis,[3][4][5] or inflamed anus or rectum,[6] and to maintain remission in Crohns disease.[3][7] It is sold in an oral form to maintain remission in ulcerative colitis and Crohns disease,[3] and as a rectal suppository[4][6] and an enema for the lower bowel conditions.[5] It is generic and sold under many brand names worldwide,[1] and there are many formulations.[8] There are no data on use in pregnant women, but the drug does cross the placenta and is excreted in breast milk. The drug should not be used in children under two, people with kidney disease, or people who are allergic to aspirin.[4] Side effects are primarily gastrointestinal but may also include headache; GI effects include nausea, diarrhea and abdominal pain. There have been scattered reports of various problems when the oral form is used, ...
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Mesalazine EP Impurity E ; 4-amino-2-hydroxybenzoic acid ; 4-Aminosalicylic acid ; 65-49-6 Cas ; Mesalazine Impurities ; Impurity of Mesalazine
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Ulcerative colitis is characterized by chronic inflammation of the colon. Typical symptoms are diarrhoea, rectal bleeding, abdominal pain and fever. The aetiology of the disease is unclear. The inflammation can be localized in the rectum or can extend to the left side or the whole colon. Treatment for induction and remission maintenance depends on the severity and extension of mucosal inflammation. Topical 5-aminosalicylates have been shown in studies to be the treatment of choice in mild to moderate ulcerative colitis. Oral 5-aminosalicylates can be used in distal, mild and moderate ulcerative colitis and for remission maintenance. For patients with a more extended or severe inflammation, oral or i.v. corticosteroids should be used. Patients with severe and/or chronic disease require immunosuppressive therapy with azathioprine or 6-mercaptopurine. For patients with severe, chronic, refractory disease, cyclosporine i.v. can be used. If no response to treatment is seen, proctocolectomy should be ...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
1. To investigate the role of interleukin-1β in chronic ulcerative colitis, we quantified interleukin-1β steady-state release into the colonic lumen.. 2. We studied 26 patients with untreated chronic ulcerative colitis and seven patients with irritable bowel syndrome who served as disease controls. In seven ulcerative colitis patients, the disease was inactive and in 19 it was mild to moderately active, according to clinical and colonoscopic criteria. Seven patients with active colitis were studied before and after 4 weeks of treatment with oral 5-aminosalicylic acid.. 3. Colonic perfusions were performed using a double-lumen technique. An isotonic solution was continuously infused 50 cm from the anal verge at 5 ml/min, and was recovered 30 cm distally by siphonage. Interleukin-1β was measured by ELISA, polymorphonuclear elastase by immunoactivation and leukotriene B4 by specific RIA.. 4. All control patients and five out of seven patients with inactive colitis had undetectable ...
Potential biomarkers for Crohns disease (CD) and ulcerative colitis (UC) were identified from two sets of full thickness pathologic samples utilizing DermArray® and PharmArray® DNA microarrays relative to uninvolved (Un) colon or normal colon. Seven of the over-expressed genes were verified using quantitative RT-PCR (i.e., TMPT, FABP1, IFI27, LCN2, COL11A2, HXB, and metallothionein). By correlating gene expression profiles between inflammatory bowel disease (IBD) tissue samples and IBD drug-treated cell cultures it might be possible to identify new candidate molecular target genes for IBD therapy and drug discovery. Potential biomarkers for CaCo2 cell cultures, which are routinely used as a GI tract surrogate model for in vitro pharmacokinetic studies, treated with azathioprine, 5-aminosalicylic acid, metronidazole, and prednisone were also identified from another experiment. Metallothionein mRNA expression was found to be down-regulated in azathioprine-treated CaCo2 cells, and was ...
Background: Data from general practice (GP) records in North Tees (Rubin et al, 2000) suggested a higher prevalence of inflammatory bowel disease (IBD) than previous estimates from hospital data. Regular prescribing of 5-aminosalicylic acid (5-ASA) therapy can reduce the risk of colorectal cancer in patients with ulcerative colitis (UC). Aims: To estimate IBD prevalence from GP records in the Trent region of central England and describe the management of patients with this condition, including data regarding 5-ASA prescribing and compliance in UC. Methods: 15 general practices recruited through the Trent Focus Collaborative Research Network provided data on confirmed cases of IBD using a standardised data collection form. Results: 344 patients with IBD were identified from a combined GP list size of 86 801, suggesting a prevalence of 396 per 100 000 (95% confidence interval 356 to 440), much higher than previous estimates from secondary care and similar to results from North Tees. Approximately ...
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907 ...
Administration of probiotics results in additional benefit in inducing remission of patients with UC. VSL#3 are beneficial for maintaining remission in patients with pouchitis. And, probiotics can provide the similar effect as 5-aminosalicylic acid on maintaining remission of UC, although no additio …
The goals of pharmacotherapy in Crohn disease are to reduce morbidity and prevent complications. Agent classes used include 5-aminosalicylic acid (5-ASA) derivatives, corticosteroids, immunosuppressiv... more
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Harvesting lab-raised zebrafish based on their size led to differences in the activity of more than 4,000 genes, as well as changes in allele frequencies of those genes, in the fish that remained.. 0 Comments. ...
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PARP-AMINO SALICYLIC ACID, ITS SALTS, ITS DERIVATIVES 389. PARECOXIB 390. PAROXETINE HYDROCHLORIDE ...
J04AA Aminosalicylic acid and derivatives[edit]. J04AA01 Aminosalicylic acid. J04AA02 Sodium aminosalicylate. J04AA03 Calcium ...
"4-Aminosalicylic acid and its derivatives. Part II. The synthesis of 4-amino-2 : 5- and 4-amino-2 : 3-dihydroxybenzoic acid". J ... S. C. Bhattacharyya, B. Lythgoe (12 February 1949). "Triterpene Acids". Nature. 163: 259. Bibcode:1949Natur.163..259B. doi: ... 105 (1). S. C. Bhattacharyya, B. Lythgoe (12 February 1949). "Triterpene Acids". Nature. 163: 259. Bibcode:1949Natur.163..259B ...
4-Aminosalicylic acid Mesalazine Salsalate "Salicylamide". Dictionary.com. Merriam-Webster's Medical Dictionary. Merriam- ...
Lehmann, J. (1946). "Para-aminosalicylic acid in the treatment of tuberculosis". Lancet. 1 (6384): 15-16. doi:10.1016/s0140- ...
There is increasing evidence for the effectiveness of mesalazine (5-aminosalicylic acid) in the treatment of IBS. Mesalazine is ... Klotz U (February 2012). "The pharmacological profile and clinical use of mesalazine (5-aminosalicylic acid)". ... Bile acid malabsorption is also sometimes missed in patients with diarrhea-predominant IBS. SeHCAT tests suggest around 30% of ... Proton pump inhibitors (PPIs) used to suppress stomach acid production may cause bacterial overgrowth leading to IBS symptoms. ...
In 1977, it was shown that 5-aminosalicylic acid (5-ASA, mesalazine/mesalamine) was the therapeutically active component in ... Marshall JK, Thabane M, Steinhart AH, Newman JR, Anand A, Irvine EJ (November 2012). "Rectal 5-aminosalicylic acid for ... "Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis". The Cochrane Database of Systematic Reviews. 8: ... "Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis". The Cochrane Database of Systematic Reviews. 8 ...
These were found in a treatment combining conteben with PAS acid p-amino-salicylic acid. John Buckingham (2 December 1993). ... and p-Amino-Salicylic Acid". doi:10.1111/j.0954-6820.1952.tb14267.x. Chemindustry "Im November 1947 macht der für alles Neue ... although it is thought to interfere with mycolic acid synthesis. One of the documented adverse effects of thioacetazone is the ...
Murphy, Seamus Joseph; Mayer, Lloyd; Abreu, Maria T. (January 2011). "Mesalamine (5-aminosalicylic acid) therapy well tolerated ...
... releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA, in the large intestine. Its advantage over that ... That product is then treated with nitrous acid to give the diazonium salt. Reaction of this species with salicylic acid ... Starting material is 4-aminohippuric acid, obtained by coupling para-aminobenzoic acid and glycine. ...
4-Aminosalicylic acid (another antituberculosis drug) significantly reduces absorption of rifampicin, and peak concentrations ... Cluster I is amino acids 509 to 533, cluster II is amino acids 563 to 572, and cluster III is amino acid 687. When describing ... Charity JC, Katz E, Moss B (March 2007). "Amino acid substitutions at multiple sites within the vaccinia virus D13 scaffold ... A change in amino acid 531 from serine to leucine arising from a change in the DNA sequence of TCG to TTG is the most common ...
It is unclear exactly how it works but is broken down into sulfapyridine and 5-aminosalicylic acid. Sulfasalazine was approved ... also known as 5-aminosalicylic acid or 5-ASA). Both metabolites are active; most of the sulfapyridine is absorbed and then ... Hernández-Díaz, Sonia; Werler, Martha M.; Walker, Alexander M.; Mitchell, Allen A. (2000). "Folic Acid Antagonists during ...
"The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
The niacin test strip is typically composed of potassium thiocyanate, chloramine-T, citric acid, and 4-Aminosalicylic acid. In ... Because lab samples that are determined to be acid-fast bacilli are possibly M. tuberculosis, a biosafety level 3 organism, all ... The niacin test detects niacin (nicotinic acid) in aqueous extracts of a culture. M. tuberculosis strains that test negative ... the presence of citric acid, chloramine-T and potassium thiocyanate will react to form cyanogen chloride. This chemical will ...
In 1957 when Streptomycin and Para-Aminosalicylic acid were used for prolonged chemotherapy surgery was no longer needed for TB ...
Three new antibiotic drugs were introduced to the cure for tuberculosis in 1947: Streptomycin, Para-amino Salicylic Acid, and ...
Aminosalicylic acids 3-Hydroxyanthranilic acid Mesalazine o-Nitroanisole 3-Nitrobenzyl alcohol Salicylhydroxamic acid. ...
The anti-inflammatory action in all these drugs is produced by 5-aminosalicylic acid (5-ASA), the active ingredient in ... The aminosalicylates used to treat ulcerative colitis include the following: Mesalazine, also known as 5-aminosalicylic acid, ... "MedlinePlus Herbs and Supplements: Omega-3 fatty acids, fish oil, alpha-linolenic acid". Archived from the original on May 18, ... Folic acid might also be counter-productive for patients taking 6-MP and related drugs that inhibit all cell division. It is ...
The class includes among others: 4-Aminosalicylic acid Balsalazide Olsalazine Sulfasalazine Mesalazine (5-Aminosalicylic acid) ...
... , also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
... including the author of the Paser Crossword Stela 4-Aminosalicylic acid, an antibiotic sold by Jacobus Pharmaceutical under the ...
Medications used to treat the symptoms of Crohn's disease include 5-aminosalicylic acid (5-ASA) formulations, prednisone, ... polyunsaturated fatty acids, meat, and omega-6 fatty acids may increase the risk of Crohn's. Smoking may increase Crohn's ... This is due to a decrease in bile acid resorption in the ileum and the bile gets excreted in the stool. As a result, the ... Bile acid diarrhea is another complication following surgery for Crohn's disease in which the terminal ileum has been removed. ...
Para-amino salicylic acid in 1957, and Neuroxin-12, a single-vial mixture of vitamin B1, vitamin B6, and vitamin B12, in 1959. ...
The type strain is resistant to p-aminosalicylic acid and isoniazid but susceptible to ethambutol, ethionamide, kanamycin, ... Microscopy Gram positive, acid-fast coccobacilli that may form cell aggregates in culture. Spores and cell branching are not ... Growth characteristics, acid-fastness and results of 16S rRNA gene sequencing were consistent with those of the genus ... A single cluster of eight peaks identified by analysis of mycolic acids (HPLC) resembled those of reference patterns but ...
Rifapentine Amikacinα Capreomycinα Cycloserineα Ethionamideα Kanamycinα Levofloxacinα Linezolidα p-aminosalicylic acidα ... Amoxicillin Amoxicillin/clavulanic acid (amoxicillin + clavulanic acid) Ampicillin Benzathine benzylpenicillin Benzylpenicillin ... Ferrous salt Folic acid Hydroxocobalamin Phytomenadione Desmopressinα Heparin sodiumα Protamine sulfateα Warfarinα Deferoxamine ... Ascorbic acid Cholecalciferol Iodine Pyridoxine Retinol Riboflavin Sodium fluoride Thiamine Calcium gluconateα Acetic acid ...
... the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. ... Mesalazine (5-aminosalicylic acid). *Methyl salicylate. *Salacetamide. *Salicin. *Salicylamide. *Salicylate (salicylic acid) ... Tiaprofenic acid (tiaprofenate). *Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate). *Floctafenic ...
Keywords:4-Aminosalicylic acid, 5-Aminosalicylic acid, azo prodrug, colon-targeting, inflammatory bowel disease, sulfasalazine. ... Keywords: 4-Aminosalicylic acid, 5-Aminosalicylic acid, azo prodrug, colon-targeting, inflammatory bowel disease, sulfasalazine ... Abstract:Novel carrier-linked azo prodrugs of 4 and 5-aminosalicylic acids (4-ASA and 5-ASA respectively) using the same drugs ... Novel carrier-linked azo prodrugs of 4 and 5-aminosalicylic acids (4-ASA and 5-ASA respectively) using the same drugs as ...
Jaundice and Para-aminosalicylic Acid. Br Med J 1950; 2 doi: https://doi.org/10.1136/bmj.2.4685.949 (Published 21 October 1950) ...
3-Aminosalicylic acid 4-Aminosalicylic acid (para-aminosalicylic acid, PAS) 5-Aminosalicylic acid (mesalazine) 6-Aminosalicylic ... Aminosalicylic acid can refer to any amino derivative of salicylic acid, such as: ...
Other names: Benzoic acid, 3-amino-2-hydroxy-; Salicylic acid, 3-amino- ...
4-Aminosalicylic acid is believed to work by blocking the ability of bacteria to make folic acid. 4-Aminosalicylic acid was ... 4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) is an antibiotic primarily used to treat tuberculosis. ... The main use for 4-aminosalicylic acid is for the treatment of tuberculosis infections. Aminosalicylic acid was introduced to ... Like many commercially significant compounds, PAS has many names including para-aminosalicylic acid, p-aminosalicylic acid, 4- ...
Easy to read patient leaflet for Aminosalicylic Acid. Includes indications, proper use, special instructions, precautions, and ... Aminosalicylic Acid. Generic Name: Aminosalicylic Acid (a mee noe sal i SIL ik AS id). Brand Name: Paser ... What do I need to tell my doctor BEFORE I take Aminosalicylic Acid?. *If you have an allergy to aminosalicylic acid or any ... How is this medicine (Aminosalicylic Acid) best taken?. Use aminosalicylic acid as ordered by your doctor. Read all information ...
Aminosalicylic Acid) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... PASER (aminosalicylic acid) granules are a delayed release granule preparation of aminosalicylic acid (p-aminosalicylic acid: 4 ... Aminosalicylic acid (p-aminosalicylic acid) is 4-Amino-2-hydroxybenzoic acid. PASER granules are the free base of ... Aminosalicylic acid is rapidly degraded in acid media; the protective acid-resistant outer coating is rapidly dissolved in ...
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The sodium salt of the drug is better tolerated than the free acid. ... Aminosalicylic acids. Alternative Parents. 4-aminosalicylic acids / Salicylic acids / Aminobenzoic acids / Benzoic acids / m- ... 4-aminosalicylic acid / Aminosalicylic acid / Salicylic acid / Aminobenzoic acid or derivatives / Aminobenzoic acid / Benzoic ... 4-Aminosalicylic_acid. ATC Codes. J04AA01 - 4-aminosalicylic acid*J04AA - Aminosalicylic acid and derivatives ...
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We observed that the flavonoids epicatechin and rutin trihydrate as well as ascorbic acid and 5-aminosalicylic acid (5-ASA) ... 5-aminosalicylic acid (0.005, 0.25, 0.5 mM, 5-ASA, TCI Europe N.V., Eschborn, Germany), acetylsalicylic acid (1 mM, ASS), and N ... urea and acetylsalicylic acid (ASS), and (h) 5-aminosalicylic acid (5-ASA) was quantified by calculation of the area under the ... urea and actetylsalicylic acid (ASS), and (h) 5-aminosalicylic acid (5-ASA) was quantified by calculation of the area under the ...
Aminosalicylic acid (p-aminosalicylic acid) is 4-Amino-2-hydroxybenzoic acid. aminosalicylic acid granules are the free base of ... Aminosalicylic acid granules are a delayed release granule preparation of aminosalicylic acid (p-aminosalicylic acid; 4- ... Aminosalicylic acid is rapidly degraded in acid media; the protective acid-resistant outer coating is rapidly dissolved in ... Aminosalicylic acid granules are supplied in packets containing 4 grams of aminosalicylic acid for administration three times a ...
We tested the hypothesis that 5-aminosalicylic acid (5-ASA) inhibits toxin A-induced generation of colonic leukotriene B,sub,4 ... P. A. M. Van Hees, J. H. Bakker, and J. H. M. van Tongeren, "Effect of sulphapyridine, 5-aminosalicylic acid, and placebo in ... R. P. MacDermott, "Progress in understanding the mechanisms of action of 5-aminosalicylic acid," The American Journal of ... 5-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats. ...
A single receptor on natural killer cells recognizes an amino acid sequence conserved across Zika, dengue, and related ... tags: para-aminosalicylic acid x ecology x immunology x The Scientist. » para-aminosalicylic acid, ecology and immunology ...
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What is para-aminosalicylic acid? Meaning of para-aminosalicylic acid medical term. What does para-aminosalicylic acid mean? ... Looking for online definition of para-aminosalicylic acid in the Medical Dictionary? para-aminosalicylic acid explanation free ... para-aminosalicylic acid. /para-ami·no·sal·i·cyl·ic ac·id/ (-ah-me″no-sal-ĭ-sil´ik) aminosalicylic acid.. para-aminosalicylic ... Related to para-aminosalicylic acid: Sodium aminosalicylate. p-aminosalicylic acid. (PAS) (PASA) [ah-me″no-sal-ĭ-sil´ik] an ...
P-aminosalicylic acid is an antibiotic medication that works by killing or slowing down the bacteria that cause tuberculosis. ... P-aminosalicylic acid is an antibiotic medication that works by killing or slowing down the bacteria that cause tuberculosis. ... However, the exact manner in which P-aminosalicylic acid works is still being studied. ...
5-Aminosalicylic Acid DerivativesThe 5-ASA derivative agents are used to treat mild-to-moderate Crohn disease and to maintain ... 5-Aminosalicylic Acid Derivatives. The 5-ASA derivative agents are used to treat mild-to-moderate Crohn disease and to maintain ... Which medications in the drug class 5-Aminosalicylic Acid Derivatives are used in the treatment of Crohn Disease?. Updated: Jul ...
Chemical structure analogous to that of folic acid. Prevents conversion of dihydrofolate to tetrahydrofolate by competitively ...
5-Aminosalicylic Acid Derivatives. Class Summary. These agents are effective in reducing inflammatory reactions. All of the ... It forms a protective coating that acts locally to protect the gastric lining against peptic acid, pepsin, and bile salts. ... Treatment of diversion colitis by short-chain fatty acids. Prospective and double-blind study. Dis Colon Rectum. 1991 Oct. 34( ... Metabolites of the drug may decrease inflammation by blocking the production of arachidonic acid metabolites in colonic mucosa. ...
where to buy 89-57-6(5-Aminosalicylic acid).Also offer free database of 89-57-6(5-Aminosalicylic acid) including MSDS sheet( ... m-Aminosalicylic acid;Sodium 5-aminosalicylate;5-Aminosalicyclic Acid;Mesalazine5-Aminosalicylic acid;5-Aminosalicylic acid ( ... English name: 5-Aminosalicylic acid Another name:Mesalamine Synonyms:Benzoic acid, 5-amino-2-hydroxy-;Asacol (TN);Benzoic acid ... 5-Aminosalicylic acid Basic information Product Name: 5-Aminosalicylic acid Synonyms: LABOTEST-BB LT00134704;IFLAB-BB F1918- ...
Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis ... Folate biosynthesis is an established anti-infective target, and the antifolate para-aminosalicylic acid (PAS) was one of the ... Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis ... Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis ...
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  • Corticosteroids inhibit formation of arachidonic acid from phospholipids when cell membranes are damaged. (tabers.com)
  • You must check to make sure that it is safe for you to take aminosalicylic acid with all of your drugs and health problems. (drugs.com)
  • Novel carrier-linked azo prodrugs of 4 and 5-aminosalicylic acids (4-ASA and 5-ASA respectively) using the same drugs as carriers in different permutations and combinations were designed for targeting colon affected with inflammatory bowel disease (IBD). (eurekaselect.com)
  • Decade of experience as well as adequacy of resources has supported and enhanced our capabilities to bring high grade Bulk Drugs, Aminosalicylic Acid as well as Drug Intermediates. (vaikunthchemicals.in)
  • The influence of intestinal transit time on the release of 5‐ aminosalicylic acid (5‐ASA) from a peroral, slow‐release preparation (Pentasa) was studied at steady state in seven healthy volunteers. (desi.pw)
  • The packets contain 4 grams of aminosalicylic acid for oral administration three times a day by sprinkling an apple sauce or yogurt to be eaten without chewing. (rxlist.com)
  • BACKGROUND: A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5-aminosalicylic acid (5-ASA). (tcd.ie)
  • Randomised controlled trials assessing the efficacy of oral 5-aminosalicylic acid (5-ASA) agents for maintenance of medically-induced remission in Crohn's disease have produced conflicting results. (uclan.ac.uk)
  • Dhaneshwar Suneela, Vadnerkar Gaurav and Rai Himanshu, "Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for Inflammatory Bowel Disease: A Colon-Targeted Approach", Inflammation & Allergy - Drug Targets (Discontinued) (2013) 12: 328. (eurekaselect.com)
  • 5-Aminosalicylic acid is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease. (abmole.com)
  • in revised form: 22 April 2012 / Accepted: 22 May 2012 / Published: 24 May 2012 Abstract: In this study, solution enhanced dispersion by supercritical fluids (SEDS) technique was applied for the preparation of 5-aminosalicylic acid (5-ASA) loaded Eudragit S100 (EU S100) nanoparticles. (sciencedocbox.com)
  • It is a building block or proteins, participates in the citric acid and urea cycles, and is a neurotransmitter. (tabers.com)
  • Certain factors that alter gastrointestinal function can contribute to IBS symptoms, including stress, prior gastroenteritis, changes in the gut microbiome, and bile acids and short-chain fatty acids, which may stimulate serotonin (5-HT) release and increase colonic permeability and motility. (mayoclinic.org)
  • in diabetic ketoacidosis, when the conversion of fatty acids to ketones increases. (tabers.com)
  • We could show that the flavonoids (−)-epicatechin, (+)-catechin hydrate, and rutin trihydrate as well as vitamin C and the pharmacological substances N -acetyl-L-cysteine and 5-aminosalicylic acid inhibited PMA induced ROS production and NET formation. (hindawi.com)
  • the protective acid-resistant outer coating is rapidly dissolved in neutral media so a mildly acidic food such as orange, apple or tomato juice, yogurt or apple sauce should be used. (rxlist.com)