AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsHealth Care
Aminosalicylic AcidsMesalamineAminosalicylic AcidSulfapyridineSulfasalazineAnti-Inflammatory Agents, Non-SteroidalColitis, UlcerativeEnemaPhenylhydrazinesInflammatory Bowel DiseasesProctitisDelayed-Action PreparationsSuppositoriesAzathioprineGastrointestinal Agents6-MercaptopurineSulfanilamidesColonAdministration, RectalSalicylatesTablets, Enteric-CoatedAmyloseCrohn DiseaseColitisAnti-Inflammatory AgentsTabletsAdministration, OralIntestinal AbsorptionAnti-Ulcer AgentsPrednisoloneChemistry, PharmaceuticalAdrenal Cortex HormonesDouble-Blind MethodPatient ComplianceIntestinesIleumDose-Response Relationship, DrugTuberculosisTuberculosis, PulmonaryMycobacterium tuberculosisTuberculosis, Multidrug-ResistantAntitubercular AgentsPregnancyWasting Syndrome
Aminosalicylic Acids
A group of 2-hydroxybenzoic acids that can be substituted by amino groups at any of the 3-, 4-, 5-, or 6-positions.
Mesalamine
An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
Aminosalicylic Acid
An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.
Sulfapyridine
Antibacterial, potentially toxic, used to treat certain skin diseases.
Sulfasalazine
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Colitis, Ulcerative
Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
Enema
A solution or compound that is introduced into the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.
Phenylhydrazines
Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)
Inflammatory Bowel Diseases
Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.
Proctitis
INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).
Delayed-Action Preparations
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Suppositories
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Azathioprine
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Gastrointestinal Agents
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
6-Mercaptopurine
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Sulfanilamides
Compounds based on 4-aminobenzenesulfonamide. The '-anil-' part of the name refers to aniline.
Colon
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Administration, Rectal
The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.
Salicylates
The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
Tablets, Enteric-Coated
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Amylose
An unbranched glucan in starch.
Crohn Disease
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION.
Tablets
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Intestinal Absorption
Uptake of substances through the lining of the INTESTINES.
Anti-Ulcer Agents
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Prednisolone
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Chemistry, Pharmaceutical
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Adrenal Cortex Hormones
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Patient Compliance
Voluntary cooperation of the patient in following a prescribed regimen.
Intestines
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
Ileum
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.
Tuberculosis, Pulmonary
MYCOBACTERIUM infections of the lung.
Mycobacterium tuberculosis
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
Tuberculosis, Multidrug-Resistant
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
Antitubercular Agents
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Wasting Syndrome
A condition of involuntary weight loss of greater then 10% of baseline body weight. It is characterized by atrophy of muscles and depletion of lean body mass. Wasting is a sign of MALNUTRITION as a result of inadequate dietary intake, malabsorption, or hypermetabolism.

The systemic load and efficient delivery of active 5-aminosalicylic acid in patients with ulcerative colitis on treatment with olsalazine or mesalazine. (1/215)

BACKGROUND: There have been reports of nephrotoxic reactions in patients with ulcerative colitis treated with 5-aminosalicylic acid (5-ASA) preparations. AIM: To compare the efficacy in delivery of active 5-ASA to the colon and the systemic load as the basis for potential long-term toxicity during treatment with olsalazine or mesalazine in patients with ulcerative colitis in remission. PATIENTS AND METHODS: Fifteen patients with ulcerative colitis were treated with olsalazine or mesalazine, each for 7 days in an open, randomized, crossover design study. 5-ASA and acetyl-5-ASA (Ac-5-ASA) in plasma and urine were measured by high performance liquid chromatography. RESULTS: The plasma concentration of 5-ASA was 1.2 +/- 0.1 micromol/L (mean +/- S.E.M.) for olsalazine and 8.0 +/- 1.9 micromol/L for mesalazine, while the plasma concentration of Ac-5-ASA was 2.8 +/- 0.2 micromol/L for olsalazine and 10.8 +/- 1.6 micromol/L for mesalazine. The amount of 5-ASA excreted in the urine was 68 +/- 30 micromol/24 h for olsalazine and 593 +/- 164 micromol/24 h for mesalazine. The amount of Ac-5-ASA in the urine was 1260 +/- 102 micromol/24 h for olsalazine and 3223 +/- 229 micromol/24 h for mesalazine. The urinary recovery of total 5-ASA plus Ac-5-ASA (as a percentage of the given dose) was 23 +/- 2.1% for olsalazine and 39 +/- 3.6% for mesalazine. The ratio between the plasma concentrations of mesalazine and olsalazine differed significantly both for 5-ASA (5.1) and Ac-5-ASA (3.6); for 5-ASA (9. 9) and Ac-5-ASA (2.6) in urine, and for the urinary recovery of total 5-ASA plus Ac-5-ASA (1.7). Moreover, in the mesalazine group there was a large variation in the individual plasma concentrations of 5-ASA and Ac-5-ASA, with maximal values 5-6-fold higher than that in the olsalazine group. CONCLUSION: The systemic load of active 5-ASA is significantly higher for mesalazine than for olsalazine, when based on the dosages given and when calculated on an equimolar basis. Some of the patients in the mesalazine group showed unexpected high levels of plasma and urinary 5-ASA concentrations, a finding which may have long-term safety implications.  (+info)

Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies. (2/215)

BACKGROUND: The therapeutic efficacy of 5-aminosalicylic acid in inflammatory bowel disease may be related to its antioxidant properties. AIM: To compare in vitro the antioxidant effects of conventional drugs (5-aminosalicylic acid, corticosteroids, metronidazole), with new aminosalicylates (4-aminosalicylic acid, balsalazide) and other potential therapies (ascorbate, N-acetylcysteine, glutathione, verapamil). METHODS: Compounds were assessed for efficacy in reducing the in vitro production of reactive oxygen species by cell-free systems (using xanthine/xanthine oxidase, with or without myeloperoxidase) and by colorectal biopsies from patients with ulcerative colitis using luminol-amplified chemiluminescence. RESULTS: 5-aminosalicylic acid and balsalazide were more potent antioxidants than 4-aminosalicylic acid or N-acetyl-5-aminosalicylic acid in cell-free systems. 5-aminosalicylic acid (20 mM) and balsalazide (20 mM) inhibited rectal biopsy chemiluminescence by 93% and 100%, respectively, compared with only 59% inhibition by 4-aminosalicylic acid (20 mM). Hydrocortisone, metronidazole and verapamil had no significant effect on chemiluminescence in any system. Ascorbate (20 mM) inhibited chemiluminescence by 100% in cell-free systems and by 60% in rectal biopsies. N-acetyl cysteine (10 mM), and both oxidized and reduced glutathione (10 mM), completely inhibited chemiluminescence in cell-free systems, but not with rectal biopsies. CONCLUSIONS: The antioxidant effects of compounds varies between cell-free systems and inflamed colorectal biopsies. The effect of drugs on the chemiluminescence produced by these two assay systems is useful for screening potentially new antioxidant treatments for inflammatory bowel disease. Ascorbate seems worth further study as a novel therapy.  (+info)

Review article: the efficacy of infliximab in Crohn's disease--healing of fistulae. (3/215)

In the management of fistulae, the current therapeutic approach is the use of a combination of antibiotics and/or a combination of immunomodulatory agents. However, clinicians treating patients with fistulae, particularly those with fistulizing Crohn's disease, have little data from controlled clinical trials of these pharmacologic agents or regimens to substantiate their use in treating this complication. Therapy with the anti-tumour necrosis factor-alpha antibody, infliximab, has shown promise in treating patients with Crohn's disease and those with the disease complicated by fistulae. A recent clinical trial was designed specifically to evaluate infliximab in the treatment of fistulizing Crohn's disease. Study results demonstrated infliximab to be the first therapeutic agent to show statistical efficacy in fistulae closure in a placebo-controlled trial. Therapy with the chimeric monoclonal antibody was characterized by a rapid onset of closure and a lasting benefit of action. Two patient cases from the clinical trial are presented to exemplify the dramatic effectiveness of this novel therapeutic approach in modulating the immune response of patients with this debilitating complication of Crohn's disease.  (+info)

Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat. (4/215)

The present study was undertaken to investigate the intestinal anti-inflammatory effects of UR-12746 on the acute and chronic stages of a trinitrobenzene sulphonic acid (TNBS) experimental model of inflammatory bowel disease (IBD) in the rat. UR-12746 is a novel, locally-acting compound which combines, through an azo bond, 5-aminosalicylic (5-ASA) and UR-12715, a potent platelet activating factor (PAF)-antagonist. UR-12746 oral pretreatment of colitic rats (50 and 100 mg kg(-1)) reduced acute colonic damage when evaluated 2 days after colonic insult. Postreatment for 4 weeks with UR-12746 (50 and 100 mg kg(-1)) resulted in a faster recovery of the damaged colonic mucosa, which was macroscopically significant from the third week. The intestinal anti-inflammatory effect of UR-12746 was associated with a decrease in leukocyte infiltration in the colonic mucosa, which was evidenced both biochemically, by a reduction in myeloperoxidase activity, and histologically, by a lower leukocyte count after morphometric analysis. This effect was higher than that seen with sulphasalazine, when assayed at the same doses and in the same experimental conditions. Several mechanisms can be involved in the beneficial effects showed by UR-12746: inhibition of leukotriene B(4) synthesis in the inflamed colon, improvement of the altered colonic oxidative status, and reduction of colonic interleukin-1beta production. The results suggest that the intestinal anti-inflammatory activity of UR-12746 can be attributed to the additive effects exerted by 5-ASA and UR-12715, the PAF antagonist compound, that are released in the colonic lumen after reduction of the azo bond by the intestinal bacteria.  (+info)

Minimal renal dysfunction in inflammatory bowel disease is related to disease activity but not to 5-ASA use. (5/215)

BACKGROUND: Conflicting data exist about proteinuria in inflammatory bowel diseases. It is still unclear whether the occurrence of proteinuria in inflammatory bowel disease patients is an extra-intestinal manifestation of disease or the result of adverse effects to medication, especially to aminosalicylates (ASA). METHODS: A total of 95 patients (51 with Crohn's disease and 44 with ulcerative colitis) were enrolled in the study. Disease activity was assessed by Crohn's Disease Activity Index (CDAI) or the Truelove index, respectively. Urine was collected over 24 h and protein excretion of specific marker proteins for tubular (alpha 1-microglobulin-alpha 1-MG) and glomerular (albumin-Alb, Immunoglobulin G-IgG) dysfunction was measured using a highly sensitive immunoluminometric assay. RESULTS: Out of 51 Crohn's disease patients, 20 showed elevated urinary alpha 1-MG. The amount of alpha 1-MGuria was strongly correlated to the CDAI (r=0.6, P < 0.001). Only four Crohn's disease patients showed slightly elevated values for glomerular proteins in urine. Similar results were obtained for ulcerative colitis: whereas only two ulcerative colitis patients showed albuminuria, tubular proteinuria was detected in 28 out of 44 ulcerative colitis patients. Proteinuria was strongly dependent on disease activity (P < 0.01) but was not related to ASA treatment. CONCLUSIONS: Proteinuria of tubular marker proteins occurs in the majority of inflammatory bowel disease patients and is related to disease activity rather than to ASA treatment. Tubular proteinuria seems to reflect a renal extra-intestinal manifestation of inflammatory bowel disease and may serve as a new relevant marker of disease activity.  (+info)

NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines. (6/215)

The activation of a self-amplifying cascade of caspases, of which caspase-8 is the apical protease, mediates Fas-, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-, and TNF-alpha-induced apoptosis in colon cell lines. Nitric oxide (NO) protects from apoptosis induced by Fas and TNF-alpha. We examined whether NCX-456, an NO-releasing derivative of mesalamine, protects colon epithelial cells from cytokine-induced apoptosis. Caco-2 and HT-29 cell lines express death factor receptors and are driven to apoptosis in response to incubation with Fas-agonistic antibody, TNF-alpha/interferon-gamma, and TRAIL. The two novel observations reported here are that 1) cotreatment of cells with NCX-456, but not mesalamine, resulted in concentration-dependent protection against death factor-induced apoptosis and inhibition of caspase activity, and 2) exposure to dithiothreitol, an agent that effectively removes NO from thiol groups, resulted in a 70% recovery of caspase activity, which is consistent with S-nitrosation as a major mechanism for caspase inactivation. These data suggest that caspase S-nitrosation represents a mechanism for protection of colonic mucosal epithelial cells from death factor-induced death.  (+info)

Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study. (7/215)

BACKGROUND AND AIMS: The benefit of 5-aminosalicylic acid therapy for maintenance of remission in Crohn's disease is controversial. The primary aim of this study was to evaluate the prophylactic properties of olsalazine in comparison with placebo for maintenance of remission in quiescent Crohn's colitis and/or ileocolitis. METHODS: In this randomised, double blind, parallel group study of olsalazine versus placebo, 328 patients with quiescent Crohn's colitis and/or ileocolitis were recruited. Treatment consisted of olsalazine 2.0 g daily or placebo for 52 weeks. The primary end point of efficacy was relapse, as defined by the Crohn's disease activity index (CDAI) and by clinical relapse. Laboratory and clinical disease activity indicators were also measured. Safety analysis consisted of documentation of adverse events and laboratory values. RESULTS: No differences in the frequency of termination due to relapse or time to termination due to relapse were noted between the two treatment groups (olsalazine 48.5% v placebo 45%) for either colitis or ileocolitis. The failure rate, defined as not completing the study, was significantly higher in olsalazine treated patients compared with placebo treated patients for the overall population (colitis and/or ileocolitis: olsalazine 65.4% v 53.9%; p=0.038). Similar failure rates were seen for patients with colitis. A significantly higher percentage of olsalazine treated patients experienced adverse gastrointestinal events. Drug attributed adverse events were reported more frequently in the olsalazine treated group with gastrointestinal symptoms being causally related to olsalazine treatment (olsalazine 40.7% v placebo 26.9%; p=0.010). Back pain was reported significantly more often by the placebo treated group. However, serious medical events did not differ between the two groups. Adverse events led to more early withdrawals in the olsalazine treated group than in the placebo treated group; thus average time in the study for patients in the olsalazine treatment group was significantly shorter than that of patients in the placebo group. CONCLUSIONS: Patients treated with olsalazine were more likely to terminate their participation in the trial than those taking placebo. This difference was not related to relapse of disease, as measured by CDAI and clinical measures, but rather was due to the development of intolerable adverse medical events of a non-serious nature related to the gastrointestinal tract. The gastrointestinal related events in the olsalazine treated group may be due to the difference in gastrointestinal status at baseline which favoured the placebo treatment group.  (+info)

Review article: balsalazide therapy in ulcerative colitis. (8/215)

Balsalazide is a 5-aminosalicylic acid (mesalazine) pro-drug which has an inert carrier molecule instead of the sulfapyridine moiety of sulfasalazine. It is designed to deliver 5-aminosalicylic acid to the colonic mucosa without the sulfapyridine-associated side-effects encountered with sulfasalazine. Several studies have confirmed the efficacy and patient tolerance of balsalazide. When compared to mesalazine at equivalent doses, it induced symptomatic and complete remission of acute ulcerative colitis in a greater proportion of patients. In particular, patients with resistant left-sided disease were shown to have a higher probability of achieving remission. Balsalazide was beneficial in patients with troublesome nocturnal symptoms. It has a similar efficacy in maintaining remission when compared to sulfasalazine and mesalazine. The advantage of balsalazide over other 5-aminosalicylic acid compounds is its superior patient tolerability with minimal side-effects.  (+info)

Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for...Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for...
Title:Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for Inflammatory Bowel Disease: A Colon-Targeted Approach. VOLUME: 12 ISSUE: 5. Author(s):Dhaneshwar Suneela, Vadnerkar Gaurav and Rai Himanshu. Affiliation:Department of Pharmaceutical Chemistry, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune-411038, Maharashtra, India.. Keywords:4-Aminosalicylic acid, 5-Aminosalicylic acid, azo prodrug, colon-targeting, inflammatory bowel disease, sulfasalazine.. Abstract:Novel carrier-linked azo prodrugs of 4 and 5-aminosalicylic acids (4-ASA and 5-ASA respectively) using the same drugs as carriers in different permutations and combinations were designed for targeting colon affected with inflammatory bowel disease (IBD). Improved hydrophilic nature of the prodrugs assisted in minimizing their absorption in upper GIT and efficient delivery of the active drugs to colon as evidenced from their stability in aqueous ...
http://www.eurekaselect.com/114960/article
Controlled trial comparing olsalazine and sulphasalazine for maintenance treatment of ulcerative colitis. - Nuffield Department...
Olsalazine and sulphasalazine were compared in a double-blind, double-dummy trial in the prevention of relapse of ulcerative colitis over 6 months. The majority were taking sulphasalazine. They were randomized to receive either olsalazine, 500 mg b.d., or sulphasalazine, 1 g b.d. Of 82 patients, 16 relapsed on olsalazine compared with 10 of 82 on sulphasalazine. This difference was not statistically significant (p = 0.16). Twenty-one patients reported adverse events in the olsalazine group, of whom 16 were withdrawn, while 20 patients reported adverse events in the sulphasalazine group, with 9 of them being withdrawn. The differences were not statistically significant. No major haematological or biochemical abnormalities occurred. Thus, olsalazine is similar to sulphasalazine for the prevention of relapse of ulcerative colitis.
https://www.ndm.ox.ac.uk/publications/135373
Global 5-Aminosalicylic Acid Market Research Report 2018 : ReportsnReports
[123 Pages Report] Check for Discount on Global 5-Aminosalicylic Acid Market Research Report 2018 report by QYResearch Group. In this report, the global 5-Aminosalicylic Acid market is...
http://www.reportsnreports.com/reports/1285122-global-5-aminosalicylic-acid-market-research-report-2018.html
Suppliers of 2-Chloroacetonitrile, 5-Amino Salicylic Acid, 3-Amino Salicylic Acid, 5-Chloro Salicylic in Ankleshwar, - IndiaSuppliers of 2-Chloroacetonitrile, 5-Amino Salicylic Acid, 3-Amino Salicylic Acid, 5-Chloro Salicylic in Ankleshwar, - India
Manufacturers and Suppliers of 2-Chloroacetonitrile, 5-Amino Salicylic Acid, 3-Amino Salicylic Acid, 5-Chloro Salicylic Acid, Ferrous Fumarate, Cetirizine Dihydrochloride, Ascorbic Palmitate, in Ankleshwar, - India
https://www.needsinfo.com/company/crystal-chemie-pvt.-ltd.
METHOD OF TREATING INFLAMMATORY BOWEL DISEASE - Patent applicationMETHOD OF TREATING INFLAMMATORY BOWEL DISEASE - Patent application
0076]There has been surprisingly little work involving 4-ASA in IBD, particularly in the United States. However, in 1984, a 4-aminosalicylic acid rectal preparation was shown to have equal activity to the 5-ASA preparation (Campieri A, Lanfranchi G A, Bertoni F, Brignola C, Bazzocchi G, Minguzzi M R, and Labo G. A Double-Blind Clinical Trial to Compare the Effects of 4-Aminosalicylic Acid to 5-Aminosalicylic Acid in Topical Treatment of Ulcerative Colitis. Digestion. 1984; 29:204-208). 4-ASA enemas were shown to be more effective in inducing clinical and sigmoidoscopic improvement than placebo at either 1 or 2 gram doses for distal ulcerative colitis (Selby W S, Bennett M K, Jewell D P. Topical treatment of distal ulcerative colitis with 4-amino-salicylic acid enemas. Digestion 1984; 29:231-234). Subsequently, a 2 gram nightly 4-ASA retention enema was shown to result in significant improvement in clinical, sigmoidoscopic and histologic variables after 8 weeks in active left-sided ulcerative ...
http://www.patentsencyclopedia.com/app/20100136125
Paser (Aminosalicylic Acid): Side Effects, Interactions, Warning, Dosage & UsesPaser (Aminosalicylic Acid): Side Effects, Interactions, Warning, Dosage & Uses
Learn about Paser (Aminosalicylic Acid) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
https://www.rxlist.com/paser-drug.htm
Aminosalicylic Acid: Indications, Side Effects, Warnings - Drugs.comAminosalicylic Acid: Indications, Side Effects, Warnings - Drugs.com
Easy to read patient leaflet for Aminosalicylic Acid. Includes indications, proper use, special instructions, precautions, and possible side effects.
https://www.drugs.com/cdi/aminosalicylic-acid.html
AMINO SALICYLIC ACID manufacturing companiesAMINO SALICYLIC ACID manufacturing companies
Listing your company for AMINO SALICYLIC ACID allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo!, MSN etc ...
http://www.poulvet.com/bulk_drugs/product_companies_india.php?sclid=1683&prefix=V
Aminosalicylates - GPI MEDICAL MARIJUANA CLINIC & RESOURCESAminosalicylates - GPI MEDICAL MARIJUANA CLINIC & RESOURCES
Rationale:The major metabolite of mesalamine (5-aminosalicylic acid) is N-acetyl-5- aminosalicylic acid. Its formation is brought about by N-acetyltransferase activity in the liver and intestinal mucosa. No investigations have been performed between LIALDA and other drugs. However based on its metabolic profile mesalamine is not expected to interact with cannabis. ...
http://www.gpimedical.com/aminosalicylates.html
Sodium 4-aminosalicylate dihydrate 6018-19-5 H-NMR | C-NMR Spectral Analysis NMR SpectrumSodium 4-aminosalicylate dihydrate 6018-19-5 H-NMR | C-NMR Spectral Analysis NMR Spectrum
Sodium 4-aminosalicylate dihydrate 6018-19-5 NMR spectrum, Sodium 4-aminosalicylate dihydrate H-NMR spectral analysis, Sodium 4-aminosalicylate dihydrate C-NMR spectral analysis ect.
http://www.molbase.com/en/hnmr_6018-19-5-moldata-22293.html
balsalazide | Cignabalsalazide | Cigna
The Colazal brand of balsalazide is used to treat mild to moderate active ulcerative colitis in adults and children who are at least 5 years old. The Giazo brand of balsalazide is used to treat mild to moderate active ulcerative colitis in men who are at least 18 years old. Balsalazide may also be used for purposes not...
https://www.cigna.com/individuals-families/health-wellness/hw/medications/balsalazide-d04700a1
Review: 5-aminosalicylic acid is more effective than placebo but not sulfasalazine for ulcerative colitis | Annals of Internal...Review: 5-aminosalicylic acid is more effective than placebo but not sulfasalazine for ulcerative colitis | Annals of Internal...
Randomized controlled trials were included if they compared oral 5-ASA with sulfasalazine or placebo for a minimum of 4 weeks for acute therapy and 6 months for maintenance therapy in patients with mild-to-moderate ulcerative colitis. Of 59 trials identified, 27 met the inclusion criteria: 16 for active treatment and 11 for remission maintenance ...
http://annals.org/aim/article-abstract/2534822/review-5-aminosalicylic-acid-more-effective-than-placebo-sulfasalazine-ulcerative
PDF] 5-Aminosalicylic acid and colorectal carcinogenesis Download Ebook
Inflammatory bowel diseases are associated with increased risk of developing colitis‐associated colorectal cancer (CAC). Epidemiological data show that the consumption of ω‐3Cited by:
https://byzewivyzufatewyn.desi.pw/5-aminosalicylic-acid-and-colorectal-carcinogenesis-book-39583dl.php
Phase III Study of MLN0002 (300 mg) in Treatment of Crohn's Disease - Full Text View - ClinicalTrials.govPhase III Study of MLN0002 (300 mg) in Treatment of Crohn's Disease - Full Text View - ClinicalTrials.gov
Patients with an evidence of or suspected abdominal abscess 2. Patients with a history of subtotal or total colectomy 3. Patients who have had a resection of the small intestine in at least 3 locations or have a diagnosis of short bowel syndrome 4. Patients with ileostomy,colostomy,or internal fistula, or severe intestinal stenosis 5. Patients who started 5-aminosalicylic acid oral drug or probiotics treatment, antimicrobials to treat Crohns disease, or 30 mg/day or less of oral corticosteroids within 13 days before initiation of study drug administration. If these drugs were used within 14 days before initiation of study drug administration, the dosage must have been changed or their use discontinued within 13 days before the initiation of study drug administration 6. Patients who have received 5-aminosalicylic acid or corticosteroid enemas/suppositories, intravenous corticosteroid injections, or more than 30 mg/day of oral corticosteroids, medications for diarrhea-predominant irritable bowel ...
https://www.clinicaltrials.gov/ct2/show/NCT02038920?term=NCT02038920&rank=1
High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease - Full Text View...High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease - Full Text View...
Crohns disease involving predominantly the ileum and/or cecum. The diagnosis must have been established by radiography, endoscopy and/or biopsy (at least 2 of the 3 modalities) with at least one confirmatory test having been performed no more than 36 months before entry. The diagnosis must have been confirmed by at least one gastroenterologist ...
https://clinicaltrials.gov/show/NCT00417690
Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with...Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with...
Patients with UC chronically consume 5-ASA to reduce the frequency and severity of clinical recurrence. In spite of treatment, the clinical course of the disease is extremely variable, ranging from periods of prolonged remission to frequent episodes of relapse. Since one possible explanation for the high recurrence rate could be a poor response to treatment, a higher dosage of 5-ASA has been used to provide additional therapeutic benefit to patients. Clinical trials, however, failed to demonstrate a clear cut dose-response relationship for 5-ASA.12-16 26 27 We have demonstrated an inverse relationship between mucosal concentrations of 5-ASA and UC disease activity-that is, in the same part of the intestinal tract, the higher the drug concentration, the lower the endoscopic and histological scores. Moreover, mucosal concentrations of 5-ASA were inversely correlated with mucosal levels of sIL-2R, a marker of mucosal inflammation.. In vitro studies have demonstrated that 5-ASA inhibits the activity ...
http://gut.bmj.com/content/47/3/410
5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer | Gut5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer | Gut
Methods The influence of 5-ASA on mTOR signalling was examined in a panel of colorectal cancer cell lines. The effects of 5-ASA on the pathways that control mTOR activity were studied in detail in two different colorectal cancer cell lines, using western blot, siRNA, a phospholipase D (PLD) activity assay, proliferation assays and cell cycle analysis. The phosphorylation status of mTOR and its downstream target, ribosomal protein S6, was studied in colorectal cancers before and after topical 5-ASA treatment.. ...
https://gut.bmj.com/content/61/12/1708
DL-Adrenalin|L(-)-Epinephrine|5-Azacytidine|N4-Acetylcytosine|5-Aminosalicylic acid|--Xinxiang Tianf
Xinxiang Tianfeng Fine Chemical Co., Ltd. engaging in the research, development, production and marketing of fine chemical products, pharmaceutical raw materials and its intermediate. The cooperation project also includes synthesis of compounds, and improvement of compound production technique. Tianfeng owns a set of perfect inspection equipment and test equipment, and the production system is in compliance with GMP Quality Management Model.
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DL-Adrenalin|L(-)-Epinephrine|5-Azacytidine|N4-Acetylcytosine|5-Aminosalicylic acid|--Xinxiang Tianf
Xinxiang Tianfeng Fine Chemical Co., Ltd. engaging in the research, development, production and marketing of fine chemical products, pharmaceutical raw materials and its intermediate. The cooperation project also includes synthesis of compounds, and improvement of compound production technique. Tianfeng owns a set of perfect inspection equipment and test equipment, and the production system is in compliance with GMP Quality Management Model.
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Patent US6380386 - Substituted aminosalicylic acid amides with fungicidal effect and ... - Google PatentsPatent US6380386 - Substituted aminosalicylic acid amides with fungicidal effect and ... - Google Patents
The invention relates to novel substituted aminosalicylamides, to a plurality of processes for their preparation and to their use as fungicides, and also to novel intermediates and to a plurality of processes for their preparation.
http://www.google.com/patents/US6380386?dq=5,867,764
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Dipentum (olsalazine) - Doctor SolveDipentum (olsalazine) - Doctor Solve
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my colitis journey
aminosalicylic acid (5-ASA) - a type of drug used to reduce inflammation in inflammatory bowel disease including balsalazide, mesalazine, oslalazine and sulphasalazine anaemia - reduced number of red blood cells which carry oxygen around the body often causing fatigue due to poor intake or absorption of vitamins and iron anal fissure - a crack or…
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Dipentum (Olsalazine) - United Pharmacies (UK)Dipentum (Olsalazine) - United Pharmacies (UK)
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olsalazine, Dipentum for UC Side Effects, Uses & Dosingolsalazine, Dipentum for UC Side Effects, Uses & Dosing
Information about the ulcerative colitis drug olsalazine (Dipentum), including side effects, dosage, drug interactions, and pregnancy safety.
https://www.medicinenet.com/olsalazine/article.htm
Mesasal - Uses, Side Effects, Interactions - Canada.com
Mesasal: 5-aminosalicylic acid (5-ASA or mesalamine) belongs to the group of medications known as anti-inflammatories. It is used to treat mild to moderate ulcerative colitis and mild to moderate Crohns disease. 5-ASA acts by reducing inflammation in the bowel.
http://bodyandhealth.canada.com/drug/getdrug/mesasal
Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism<...
TY - JOUR. T1 - Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism. AU - De Boer, Nanne K.H.. AU - Wong, Dennis R.. AU - Jharap, Bindia. AU - De Graaf, Peer. AU - Hooymans, Piet M.. AU - Mulder, Chris J.J.. AU - Rijmen, Frank. AU - Engels, Leopold G.J.B.. AU - Van Bodegraven, Adriaan A.. PY - 2007/12/1. Y1 - 2007/12/1. N2 - INTRODUCTION: Studies indicated that 5-aminosalicylates (5-ASA) may influence the metabolism of thiopurines; however, conclusions were restricted as a result of number of patients or study design. AIM: To determine the influence of 5-ASA on thiopurine metabolism, we performed a prospective multicenter pharmacokinetic interaction study of two different 5-ASA dosages (2 g daily followed by 4 g daily) in 26 inflammatory bowel disease (IBD) patients during steady-state AZA or 6-MP therapy. RESULTS: The 4-wk coadministration of 2 g 5-ASA daily, followed by a 4-wk period of 4 g 5-ASA daily, led to a statistical significant increase of 40% (absolute 84 pmol/8 × ...
https://research.vumc.nl/en/publications/dose-dependent-influence-of-5-aminosalicylates-on-thiopurine-meta
poly (methacrylic acid-co-ethyleneglycol monomethoacrylate-co-methacryloyloxyethyl 5-amino salicylate) Summary Report |...poly (methacrylic acid-co-ethyleneglycol monomethoacrylate-co-methacryloyloxyethyl 5-amino salicylate) Summary Report |...
poly (methacrylic acid-co-ethyleneglycol monomethoacrylate-co-methacryloyloxyethyl 5-amino salicylate): copolymer that, upon hydrolysis, releases 5-aminosalicylic acid
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Publications - Latvijas Organiskās sintēzes institūtsPublications - Latvijas Organiskās sintēzes institūts
Markava E.; Gailīte V.; Matisova G.; Freimanis J.; Gerca L.; Muzikante I.; Rutkis M.; Tevosov A.A. Amphiphilic N-acyl-derivatives of azobenzene based on the 4-aminobenzoic and 5-aminosalicylic acids. Mol. Cryst. Liq. Cryst. 1995, 5(3), 215-222 ...
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1sxk.1 | SWISS-MODEL Template Library
SWISS-MODEL Template Library (SMTL) entry for 1sxk.1. Crystal Structure of a complex formed between phospholipase A2 and a non-specific anti-inflammatory amino salicylic acid at 1.2 A resolution
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Brevet US5010069 - Stable liquid form of 5-aminosalicylic acid - Google BrevetsBrevet US5010069 - Stable liquid form of 5-aminosalicylic acid - Google Brevets
An aqueous solution of 5-aminosalicylic acid (5-ASA) and a nontoxic alkali, alkali metal or alkaline earth metal salt of 5-aminosalicylic acid having a pH of 3-5 is disclosed. The sole buffer in the solution is that intrinsically formed by 5-aminosalicylic acid and its alkali, alkali metal or alkaline earth metal salt. The solutions preferably also contain an antioxidant and a metal complexing agent. In preferrred practice, the 5-ASA salt is formed in situ by addition of an alkali, alkali metal or alkaline earth metal hydroxide to a solution of 5-ASA. The solution is stable and does not significantly discolor due to 5-ASA decomposition for extended periods of time.
http://www.google.fr/patents/US5010069
Aminosalicylate | definition of aminosalicylate by Medical dictionaryAminosalicylate | definition of aminosalicylate by Medical dictionary
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Common use. Asacol is an anti-inflammatory drug which acts on the lining of the gut to reduce inflammation tissue damage, and diarrhea and treat ulcerative colitis, proctosigmoiditis, and proctitis. Asacol becomes active in the small intestine just before the large intestine. This drug may be also good in treatment of patients with Crohns disease which affects also the small bowel. Asacol contains active component mesalamine, an anti-inflammatory drug, which is released from covering only when ðÍ,7, and olsalazine (5-aminosalicylic acid dimer) which is also active in distal segments of gastrointestinal tract.. Dosage and direction. Consult with your doctor about necessary dosage before to start treatment. Do not use in larger quantities than prescribed. Take Asacol orally with a meal or a glass of milk. Swallow the whole pill with water. Do not break, crush or chew the tablets before to swallow them. Recommended daily dose for treatment of moderately active ulcerative colitis is 4.8g divided ...
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Proctitis and Anusitis Medication: Corticosteroids, 5-Aminosalicylic Acid Derivatives, Immunosuppressants, Antibiotics,...Proctitis and Anusitis Medication: Corticosteroids, 5-Aminosalicylic Acid Derivatives, Immunosuppressants, Antibiotics,...
Inflammation of the mucosal lining of the rectum is defined as proctitis, whereas anusitis is simply inflammation of the anal canal. Inflammation in these areas can cause symptoms, such as itching, burning, rectal bleeding, pelvic pressure, and foul-smelling discharge.
https://emedicine.medscape.com/article/192910-medication
RJPT - Estimation of Balsalazide in Bulk and in Formulation by UV-Visible Spectrophotometry
Three simple, precise and accurate UV-Visible spectrophotometric methods were developed for the estimation of Balsalazide in bulk drug and in pharmaceutical formulations. In method A, UV spectra of Balsalazide in double distilled water exhibits the absorption maxima at 358 nm. Method B is based on the formation of a dark red colored chromogen in alkaline medium at pH 12 exhibits ? max at 456 nm. Method C is the derivative spectroscopic method. The first derivative spectra were recorded between 200 and 500 nm at N=1 and the assay was carried out by measuring the absorbance at 383 nm. Beers law obeyed in the concentration range of 2-20 ?g/ml for methods A and B and 5-25 ?g/ml for method C. The accuracy of the method was determined by recovery studies. The method were validated statistically. The methods showed good reproducibility and recovery with % RSD less than 2. The methods were found to be simple, economical, accurate and reproducible and can be used for routine analysis of balsalazide in
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Mesalazine - WikipediaMesalazine - Wikipedia
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohns disease.[2] It is generally used for mildly to moderately severe disease.[2] It is taken by mouth or rectally.[2] The formulations which are taken by mouth appear to be similarly effective.[3] Common side effects include headache, nausea, abdominal pain, and fever.[2] Serious side effects may include pericarditis, liver problems, and kidney problems.[2][3] Use in pregnancy and breastfeeding appears safe.[3] In people with a sulfa allergy certain formulations may result in problems.[2] Mesalazine is an aminosalicylate and anti-inflammatory.[2][3] It works by direct contact with the intestines.[2] Mesalazine was approved for medical use in the United States in 1987.[2][4] It is available as a generic medication and sold under many brand names worldwide.[5][2] A month supply in the United Kingdom costs the NHS about £43 as of ...
https://en.wikipedia.org/wiki/Asacol
Sanatorium treatment of gastritis( in a sanatorium), where they are treated?
Many people prefer sanatoria as a treatment option for gastritis. But this is only one of the options offered to the patient. In principle, their mass. But to choose a better individual additional treatment is desirable together with the attending physician. Of course, during a period of exacerbation no resort will be in joy, and not much it can help. Sanatorium treatment of gastritis means rest, proper nutrition and saturation of the body with useful vitamins and minerals, which will have a positive effect on everything as a whole. Gastritis is a common disease that affects a large proportion of the worlds population. Every year, medicine sees an increasing number of patients with this diagnosis. First of all, this is due to improper diet and non-compliance with his regime. In addition, the nerves, tension, bad ecology and stress are detrimental. In addition, not necessarily the emergence of gastritis, many people suffer and other diseases of the gastrointestinal tract. In this case, the main ...
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Mesalazine - WikipediaMesalazine - Wikipedia
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is an aminosalicylate anti-inflammatory drug[2] used to treat inflammatory bowel disease, including ulcerative colitis,[3][4][5] or inflamed anus or rectum,[6] and to maintain remission in Crohns disease.[3][7] It is sold in an oral form to maintain remission in ulcerative colitis and Crohns disease,[3] and as a rectal suppository[4][6] and an enema for the lower bowel conditions.[5] It is generic and sold under many brand names worldwide,[1] and there are many formulations.[8] There are no data on use in pregnant women, but the drug does cross the placenta and is excreted in breast milk. The drug should not be used in children under two, people with kidney disease, or people who are allergic to aspirin.[4] Side effects are primarily gastrointestinal but may also include headache; GI effects include nausea, diarrhea and abdominal pain. There have been scattered reports of various problems when the oral form is used, ...
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Balsalazide Disodium - patient information, description, dosage and directions.Balsalazide Disodium - patient information, description, dosage and directions.
Description of the drug Balsalazide Disodium. - patient information, description, dosage and directions. What is Balsalazide Disodium!
http://drugster.info/drug/medicament/2760/
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Visible light absorption of surface modified TiO2 powders with bidentate benzene derivativesVisible light absorption of surface modified TiO2 powders with bidentate benzene derivatives
TY - JOUR AU - Milicevic, B AU - Đorđević, Vesna AU - Lončarević, Davor AU - Ahrenkiel, Scott Phillip AU - Dramićanin, Miroslav AU - Nedeljković, Jovan M. PY - 2015 UR - http://cer.ihtm.bg.ac.rs/handle/123456789/1721 AB - TiO2 powders with different specific surface area were prepared using reproducible, sol gel synthetic route and their ability to form hybrids with catechol and 5-amino salicylic acid was compared with the commercially available Degussa P25 TiO2 powder. Microstructural characterization involving transmission electron microscopy, X-ray diffraction analysis and nitrogen adsorption-desorption isotherms indicated that TiO2 samples cover reasonably wide size and/or specific surface area range (50-115 m(2)/g). The surface modification of TiO2 powders with catechol and 5-amino salicylic acid induced significant shift of absorption to the visible spectral region due to charge transfer complex formation. It should be emphasized that tunable optical properties of TiO2 in powder ...
https://cer.ihtm.bg.ac.rs/handle/123456789/1721
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2021 Ulcerative Colitis Clinical Trials, Research & Treatment2021 Ulcerative Colitis Clinical Trials, Research & Treatment
Ulcerative colitis treatment consists of a variety of approaches. Most patients can control their symptoms with ulcerative colitis drugs. In general, ulcerative colitis surgery is reserved for the most severe cases and those in which standard ulcerative colitis medication is ineffective.. 5-aminosalicylic acid (5-ASA) drugs are the most common ulcerative colitis medications. Corticosteroids are used for short-term treatment of moderate symptoms. Severe cases receive immunomodulators, which reduce inflammation but slow the bodys immune response.. Surgery can be used to remove damaged areas of the digestive tract. In profound cases, ulcerative colitis may be eliminated by removing the colon and rectum completely, a procedure called proctocolectomy.. ...
https://policylab.us/clinical-trials/ulcerative-colitis/
Ulcerative colitis: conservative management and long-term effects. | IKMB
Ulcerative colitis is characterized by chronic inflammation of the colon. Typical symptoms are diarrhoea, rectal bleeding, abdominal pain and fever. The aetiology of the disease is unclear. The inflammation can be localized in the rectum or can extend to the left side or the whole colon. Treatment for induction and remission maintenance depends on the severity and extension of mucosal inflammation. Topical 5-aminosalicylates have been shown in studies to be the treatment of choice in mild to moderate ulcerative colitis. Oral 5-aminosalicylates can be used in distal, mild and moderate ulcerative colitis and for remission maintenance. For patients with a more extended or severe inflammation, oral or i.v. corticosteroids should be used. Patients with severe and/or chronic disease require immunosuppressive therapy with azathioprine or 6-mercaptopurine. For patients with severe, chronic, refractory disease, cyclosporine i.v. can be used. If no response to treatment is seen, proctocolectomy should be ...
http://www.ikmb.uni-kiel.de/publications/ulcerative-colitis-conservative-management-and-long-term-effects
January 2018 - When do the patents on POTASSIUM AMINOSALICYLATE expire, and when will generic POTASSIUM AMINOSALICYLATE be...January 2018 - When do the patents on POTASSIUM AMINOSALICYLATE expire, and when will generic POTASSIUM AMINOSALICYLATE be...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
https://www.drugpatentwatch.com/p/tradename/POTASSIUM+AMINOSALICYLATE
Intracolonic Release in Vivo of Interleukin-1β in Chronic Ulcerative Colitis | Clinical ScienceIntracolonic Release in Vivo of Interleukin-1β in Chronic Ulcerative Colitis | Clinical Science
1. To investigate the role of interleukin-1β in chronic ulcerative colitis, we quantified interleukin-1β steady-state release into the colonic lumen.. 2. We studied 26 patients with untreated chronic ulcerative colitis and seven patients with irritable bowel syndrome who served as disease controls. In seven ulcerative colitis patients, the disease was inactive and in 19 it was mild to moderately active, according to clinical and colonoscopic criteria. Seven patients with active colitis were studied before and after 4 weeks of treatment with oral 5-aminosalicylic acid.. 3. Colonic perfusions were performed using a double-lumen technique. An isotonic solution was continuously infused 50 cm from the anal verge at 5 ml/min, and was recovered 30 cm distally by siphonage. Interleukin-1β was measured by ELISA, polymorphonuclear elastase by immunoactivation and leukotriene B4 by specific RIA.. 4. All control patients and five out of seven patients with inactive colitis had undetectable ...
http://www.clinsci.org/content/89/5/521
Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugsRegulation of gene expression in inflammatory bowel disease and correlation with IBD drugs
Potential biomarkers for Crohns disease (CD) and ulcerative colitis (UC) were identified from two sets of full thickness pathologic samples utilizing DermArray® and PharmArray® DNA microarrays relative to uninvolved (Un) colon or normal colon. Seven of the over-expressed genes were verified using quantitative RT-PCR (i.e., TMPT, FABP1, IFI27, LCN2, COL11A2, HXB, and metallothionein). By correlating gene expression profiles between inflammatory bowel disease (IBD) tissue samples and IBD drug-treated cell cultures it might be possible to identify new candidate molecular target genes for IBD therapy and drug discovery. Potential biomarkers for CaCo2 cell cultures, which are routinely used as a GI tract surrogate model for in vitro pharmacokinetic studies, treated with azathioprine, 5-aminosalicylic acid, metronidazole, and prednisone were also identified from another experiment. Metallothionein mRNA expression was found to be down-regulated in azathioprine-treated CaCo2 cells, and was ...
http://scholars.uab.edu/display/pub894597
PREVALENCE AND MANAGEMENT OF INFLAMMATORY BOWEL DISEASE: DATA FROM PRIMARY CARE RECORDS, INCLUDING 5-ASA PRESCRIBING AND...
Background: Data from general practice (GP) records in North Tees (Rubin et al, 2000) suggested a higher prevalence of inflammatory bowel disease (IBD) than previous estimates from hospital data. Regular prescribing of 5-aminosalicylic acid (5-ASA) therapy can reduce the risk of colorectal cancer in patients with ulcerative colitis (UC). Aims: To estimate IBD prevalence from GP records in the Trent region of central England and describe the management of patients with this condition, including data regarding 5-ASA prescribing and compliance in UC. Methods: 15 general practices recruited through the Trent Focus Collaborative Research Network provided data on confirmed cases of IBD using a standardised data collection form. Results: 344 patients with IBD were identified from a combined GP list size of 86 801, suggesting a prevalence of 396 per 100 000 (95% confidence interval 356 to 440), much higher than previous estimates from secondary care and similar to results from North Tees. Approximately ...
http://connection.ebscohost.com/c/articles/9747747/prevalence-management-inflammatory-bowel-disease-data-from-primary-care-records-including-5-asa-prescribing-compliance
Sulfasalazine | CTDSulfasalazine | CTD
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907 ...
http://ctdbase.org/detail.go?type=chem&acc=D012460
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohns Disease, and Pouchitis: Meta...Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohns Disease, and Pouchitis: Meta...
Administration of probiotics results in additional benefit in inducing remission of patients with UC. VSL#3 are beneficial for maintaining remission in patients with pouchitis. And, probiotics can provide the similar effect as 5-aminosalicylic acid on maintaining remission of UC, although no additio …
https://pubmed.ncbi.nlm.nih.gov/24280877/?dopt=Abstract
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What are the goals of pharmacotherapy in pediatric Crohn disease?What are the goals of pharmacotherapy in pediatric Crohn disease?
The goals of pharmacotherapy in Crohn disease are to reduce morbidity and prevent complications. Agent classes used include 5-aminosalicylic acid (5-ASA) derivatives, corticosteroids, immunosuppressiv... more
https://www.medscape.com/answers/928288-180389/what-are-the-goals-of-pharmacotherapy-in-pediatric-crohn-disease
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Recent Articles | Para-aminosalicylic Acid And Cell & Molecular Biology | The Scientist Magazine®| Page 6Recent Articles | Para-aminosalicylic Acid And Cell & Molecular Biology | The Scientist Magazine®| Page 6
Daily News Thousands of Mutations Accumulate in the Human Brain Over a Lifetime Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.. ...
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Recent Articles | Para-aminosalicylic Acid, Developmental Biology And Ecology | The Scientist Magazine®| Page 5Recent Articles | Para-aminosalicylic Acid, Developmental Biology And Ecology | The Scientist Magazine®| Page 5
Harvesting lab-raised zebrafish based on their size led to differences in the activity of more than 4,000 genes, as well as changes in allele frequencies of those genes, in the fish that remained.. 0 Comments. ...
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Peroxisome proliferator‐activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut | EMBO Molecular...Peroxisome proliferator‐activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut | EMBO Molecular...
Gene expression profiles of the Caco‐2 intestinal epithelial cell line stimulated by PPARγ agonists were first assessed by microarray analysis. We used three different PPARγ agonist: the well‐characterized pioglitazone (Pio; 1 μM) belonging to the TZD drug class (Momose et al, 1991), 5‐amino salicylic acid (5‐ASA, 30 mM) (Rousseaux et al, 2005), and a new PPARγ modulator we developed and named GED‐0507‐34‐Levo (GED; 1 and 30 mM) (Pirat et al, 2012; Mastrofrancesco et al, 2014). Among the 44,000 genes tested, we observed that the LCT gene was the most upregulated gene in cells treated with Pio and GED. The LCT gene was significantly 5.28‐fold (± 0.55; P , 0.05) upregulated by 1 mM GED, 8.28‐fold (± 1.7; P , 0.05) upregulated by 30 mM GED and 17.93‐fold (± 5.1; P , 0.05) upregulated for Pio compared to unstimulated cells. 5‐ASA also upregulated LCT mRNA expression to the same extend (8.76‐fold ± 2.06, P , 0.05) (GEO Series accession number GSE68852; ...
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Aminosalicylic acidAminosalicylic acid
3-Aminosalicylic acid 4-Aminosalicylic acid (para-aminosalicylic acid, PAS) 5-Aminosalicylic acid (mesalazine) 6-Aminosalicylic ... Aminosalicylic acid can refer to any amino derivative of salicylic acid, such as: ... acid This set index page lists chemical compounds articles associated with the same name. If an internal link led you here, you ...
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4-Aminosalicylic acid4-Aminosalicylic acid
... has many names including para-aminosalicylic acid, p-aminosalicylic acid, 4-ASA, and simply P.[medical ... 4-Aminosalicylic acid is believed to work by blocking the ability of bacteria to make folic acid. 4-Aminosalicylic acid was ... 4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) and sold under the brand name Paser among others, is an ... With heat, aminosalicylic acid is decarboxylated to produce CO2 and 3-aminophenol. 4-aminosalicylic acid has been shown to be a ...
https://en.wikipedia.org/wiki/4-Aminosalicylic_acid
Salicylic acidSalicylic acid
... is used in the production of other pharmaceuticals, including 4-aminosalicylic acid, sandulpiride, and ... acetylsalicylic acid) or methyl salicylate (oil of wintergreen) with a strong acid or base. Upon heating, salicylic acid ... Aminosalicylic acid is used to induce remission in ulcerative colitis, and has been used as an antitubercular agent often ... Salicylic acid has long been a key starting material for making acetylsalicylic acid (aspirin). Aspirin (acetylsalicylic acid ...
https://en.wikipedia.org/wiki/Salicylic_acid
SalicylamideSalicylamide
4-Aminosalicylic acid Mesalazine Salsalate "Salicylamide". Dictionary.com. Merriam-Webster's Medical Dictionary. Merriam- ...
https://en.wikipedia.org/wiki/Salicylamide
Sasanka Chandra BhattacharyyaSasanka Chandra Bhattacharyya
"4-Aminosalicylic acid and its derivatives. Part II. The synthesis of 4-amino-2 : 5- and 4-amino-2 : 3-dihydroxybenzoic acid". J ... S. C. Bhattacharyya, B. Lythgoe (12 February 1949). "Triterpene Acids". Nature. 163 (4137): 259. Bibcode:1949Natur.163..259B. ... 105 (1). S. C. Bhattacharyya, B. Lythgoe (12 February 1949). "Triterpene Acids". Nature. 163 (4137): 259. Bibcode:1949Natur.163 ...
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Ulcerative colitisUlcerative colitis
Murray A, Nguyen TM, Parker CE, Feagan BG, MacDonald JK (August 2020). "Oral 5-aminosalicylic acid for induction of remission ... Murray A, Nguyen TM, Parker CE, Feagan BG, MacDonald JK (August 2020). "Oral 5-aminosalicylic acid for maintenance of remission ... Marshall JK, Thabane M, Steinhart AH, Newman JR, Anand A, Irvine EJ (November 2012). "Rectal 5-aminosalicylic acid for ... In 1977, it was shown that 5-aminosalicylic acid (5-ASA, mesalazine/mesalamine) was the therapeutically active component in ...
https://en.wikipedia.org/wiki/Ulcerative_colitis
Dihydropteroate synthase inhibitorDihydropteroate synthase inhibitor
They include sulfonamides, dapsone, and para-aminosalicylic acid. In bacteria, antibacterial sulfonamides act as competitive ... Folate is necessary for the cell to synthesize nucleic acids (nucleic acids are essential building blocks of DNA and RNA), and ...
https://en.wikipedia.org/wiki/Dihydropteroate_synthase_inhibitor
CodrugCodrug
Sulfasalazine - sulfapyridine chemically linked to 5-aminosalicylic acid coupled with an azo linkage. It is on the World Health ... Codrug of butyric acid and ATRA, Codrug of ATRA and histone deacetylase inhibitors, 5-Fluorouracil (5-FU) and cytarabine (Ara-C ... esterified paracetamol and acetylsalicylic acid Fenethylline - amphetamine chemically linked with theophylline Lisdexamfetamine ... with an amide linkage formed by the condensation of dextroamphetamine with the carboxylate group of the essential amino acid L- ...
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Solute carrier family 38 member 9Solute carrier family 38 member 9
"New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid". PLOS ... Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1". Science. 347 (6218): 188-94. doi:10.1126/ ... Jung J, Genau HM, Behrends C (July 2015). "Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9". ... "SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1". Nature. 519 (7544): 477-81. Bibcode ...
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Irritable bowel syndromeIrritable bowel syndrome
There is increasing evidence for the effectiveness of mesalazine (5-aminosalicylic acid) in the treatment of IBS. Mesalazine is ... Klotz U (February 2012). "The pharmacological profile and clinical use of mesalazine (5-aminosalicylic acid)". Arzneimittel- ... Bile acid malabsorption is also sometimes missed in people with diarrhea-predominant IBS. SeHCAT tests suggest around 30% of ... A similar syndrome is found in rats (Rattus spp.). In rats a short-chain fatty acid receptor is involved. Karaki et al., 2006 ...
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N-acetyltransferaseN-acetyltransferase
Human NAT1 preferentially acetylates 4-aminobenzoic acid (PABA), 4 amino salicylic acid, sulfamethoxazole, and sulfanilamide. ... Polymorphisms of NAT2 include the single amino acid substitutions R64Q, I114T, D122N, L137F, Q145P, R197Q, and G286E. These are ... of their amino acid sequence. Both also have an active site cysteine residue (Cys68) in the N-terminal region. Further, all ...
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ThioacetazoneThioacetazone
These were found in a treatment combining conteben with PAS acid p-amino-salicylic acid. Thiosemicarbazide John Buckingham (2 ... and p-Amino-Salicylic Acid". Acta Medica Scandinavica. 143 (5): 323-335. doi:10.1111/j.0954-6820.1952.tb14267.x. PMID 12976024 ... although it is thought to interfere with mycolic acid synthesis. One of the documented adverse effects of thioacetazone is the ...
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Lloyd MayerLloyd Mayer
Murphy, Seamus Joseph; Mayer, Lloyd; Abreu, Maria T. (January 2011). "Mesalamine (5-aminosalicylic acid) therapy well tolerated ...
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SulfasalazineSulfasalazine
It is a codrug which is a combination of sulfapyridine and 5-aminosalicylic acid coupled with an azo linkage. In people with ... The medication is broken down by intestinal bacteria into sulfapyridine and 5-aminosalicylic acid. That which is absorbed is ... also known as 5-aminosalicylic acid or 5-ASA). Both metabolites are active; most of the sulfapyridine is absorbed and then ... Hernández-Díaz, Sonia; Werler, Martha M.; Walker, Alexander M.; Mitchell, Allen A. (2000). "Folic Acid Antagonists during ...
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CateninCatenin
"The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
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Niacin testNiacin test
The niacin test strip is typically composed of potassium thiocyanate, chloramine-T, citric acid, and 4-Aminosalicylic acid. In ... Because lab samples that are determined to be acid-fast bacilli are possibly M. tuberculosis, a biosafety level 3 organism, all ... The niacin test detects niacin (nicotinic acid) in aqueous extracts of a culture. M. tuberculosis strains that test negative ... the presence of citric acid, chloramine-T and potassium thiocyanate will react to form cyanogen chloride. This chemical will ...
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Indian hospitalIndian hospital
In 1956, Charles Camsell Indian Hospital in Edmonton used its patients to test versions of para-aminosalicylic acid (PAS); they ...
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BalsalazideBalsalazide
... releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA, in the large intestine. Its advantage over that ... That product is then treated with nitrous acid to give the diazonium salt. Reaction of this species with salicylic acid ... Starting material is 4-aminohippuric acid, obtained by coupling para-aminobenzoic acid and glycine. ...
https://en.wikipedia.org/wiki/Balsalazide
University Hospital of South Manchester NHS Foundation TrustUniversity Hospital of South Manchester NHS Foundation Trust
In 1957 when Streptomycin and Para-Aminosalicylic acid were used for prolonged chemotherapy surgery was no longer needed for TB ...
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Firland SanatoriumFirland Sanatorium
Three new antibiotic drugs were introduced to the cure for tuberculosis in 1947: Streptomycin, Para-amino Salicylic Acid, and ...
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RifampicinRifampicin
4-Aminosalicylic acid (another antituberculosis drug) significantly reduces absorption of rifampicin, and peak concentrations ... Cluster I is amino acids 509 to 533, cluster II is amino acids 563 to 572, and cluster III is amino acid 687. When describing ... Charity JC, Katz E, Moss B (March 2007). "Amino acid substitutions at multiple sites within the vaccinia virus D13 scaffold ... A change in amino acid 531 from serine to leucine arising from a change in the DNA sequence of TCG to TTG is the most common ...
https://en.wikipedia.org/wiki/Rifampicin
Management of ulcerative colitisManagement of ulcerative colitis
The anti-inflammatory action in all these drugs is produced by 5-aminosalicylic acid (5-ASA), the active ingredient in ... The aminosalicylates used to treat ulcerative colitis include the following: Mesalazine, also known as 5-aminosalicylic acid, ... "MedlinePlus Herbs and Supplements: Omega-3 fatty acids, fish oil, alpha-linolenic acid". Archived from the original on May 18, ... Folic acid might also be counter-productive for patients taking 6-MP and related drugs that inhibit all cell division. It is ...
https://en.wikipedia.org/wiki/Management_of_ulcerative_colitis
AminosalicylateAminosalicylate
The class includes among others: 4-Aminosalicylic acid Balsalazide Olsalazine Sulfasalazine Mesalazine (5-Aminosalicylic acid) ...
https://en.wikipedia.org/wiki/Aminosalicylate
History of tuberculosisHistory of tuberculosis
Para-aminosalicylic acid, discovered in 1946, was used in combination with Streptomycin to reduce the emergence of drug ...
https://en.wikipedia.org/wiki/History_of_tuberculosis
MesalazineMesalazine
... , also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease ... Salicylic acids, AbbVie brands, Takeda Pharmaceutical Company brands, Wikipedia medicine articles ready to translate). ...
https://en.wikipedia.org/wiki/Mesalazine
Jörgen LehmannJörgen Lehmann
... was a Danish-born Swedish physician and chemist best known for his discovery in the 1940s that para-amino salicylic acid (PAS) ...
https://en.wikipedia.org/wiki/Jörgen_Lehmann
Paser (disambiguation)Paser (disambiguation)
... including the author of the Paser Crossword Stela 4-Aminosalicylic acid, an antibiotic sold by Jacobus Pharmaceutical under the ...
https://en.wikipedia.org/wiki/Paser_(disambiguation)
Frederick BernheimFrederick Bernheim
... a discovery which was used by Jorgen Lehman in his development of para-aminosalicylic acid as the first synthetic anti- ...
https://en.wikipedia.org/wiki/Frederick_Bernheim
Collagenous colitisCollagenous colitis
Other medications that can be used are the following: Bismuth agents, including Pepto-Bismol 5-aminosalicylic acid ...
https://en.wikipedia.org/wiki/Collagenous_colitis
C7H7NO3C7H7NO3
The molecular formula C7H7NO3 may refer to: Aminosalicylic acids 4-Aminosalicylic acid Mesalazine 3-Hydroxyanthranilic acid o- ... Nitroanisole 3-Nitrobenzyl alcohol Salicylhydroxamic acid This set index page lists chemical structure articles associated with ...
https://en.wikipedia.org/wiki/C7H7NO3
Urine test stripUrine test strip
... p-amino salicylic acid, sulphonamide, methyldopa, procaine and chlorpromazine. The test should be carried out at room ... 1) In an acid medium Para-arsanilic acid or sulphanilamide + NO− 2 → Diazonium salt 2) In an acid medium Diazonium salt + ... 1) Reaction catalysed by leukocyte esterase Indolecarboxylic acid ester → Indoxyl + Acid 2) In acid medium Indoxyl + Diazonium ... The proportions are 78% beta-hydroxybutyric acid, 20% acetoacetic acid and 2% acetone. The test used in the urine test strips ...
https://en.wikipedia.org/wiki/Urine_test_strip
Ramanbhai PatelRamanbhai Patel
Para-amino salicylic acid in 1957, and Neuroxin-12, a single-vial mixture of vitamin B1, vitamin B6, and vitamin B12, in 1959. ...
https://en.wikipedia.org/wiki/Ramanbhai_Patel
WHO Model List of Essential MedicinesWHO Model List of Essential Medicines
... α Clofazimineα Cycloserineα Delamanidα Ethionamideα Levofloxacinα Linezolidα Meropenemα Moxifloxacinα P-aminosalicylic acidα ... Ferrous salt Ferrous salt/folic acid (ferrous salt + folic acid) Folic acid Hydroxocobalamin Erythropoiesis-stimulating agentsα ... Moxifloxacin Pyrazinamide Rifabutin Rifampicin Rifapentine Amikacinα Amoxicillin/clavulanic acid (amoxicillin + clavulanic acid ... Ethosuximideα Valproic acid (sodium valproate)α Albendazole Ivermectin Levamisole Mebendazole Niclosamide Praziquantel Pyrantel ...
https://en.wikipedia.org/wiki/WHO_Model_List_of_Essential_Medicines
Multidrug-resistant tuberculosisMultidrug-resistant tuberculosis
... p-aminosalicylic acid) For patients with RR-TB or MDR-TB, "not previously treated with second-line drugs and in whom resistance ... Amino acid replacements in the NADH binding site of InhA apparently result in INH resistance by preventing the inhibition of ... Mutation in the rpoB gene changes the sequence of amino acids and eventual conformation of the beta subunit. In this case ... "Early Bactericidal Activity of Amoxicillin in Combination with Clavulanic Acid in Patients with Sputum Smear-positive Pulmonary ...
https://en.wikipedia.org/wiki/Multidrug-resistant_tuberculosis
List of MeSH codes (D02)List of MeSH codes (D02)
... salicylic acids MeSH D02.241.511.390.700.050 - aminosalicylic acids MeSH D02.241.511.390.700.050.060 - p-aminosalicylic acid ... salicylic acids MeSH D02.755.410.700.050 - aminosalicylic acids MeSH D02.755.410.700.050.060 - p-aminosalicylic acid MeSH ... salicylic acids MeSH D02.241.223.100.380.800.050 - aminosalicylic acids MeSH D02.241.223.100.380.800.050.060 - p-aminosalicylic ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
WHO Model List of Essential Medicines for ChildrenWHO Model List of Essential Medicines for Children
... α Clofazimineα Cycloserineα Delamanidα Ethionamideα Levofloxacinα Linezolidα Meropenemα Moxifloxacinα P-aminosalicylic acidα ... Pyrazinamide Rifampicin Rifapentine Amikacinα Amoxicillin/clavulanic acidα (amoxicillin + clavulanic acid) Bedaquiline ... Ethosuximideα Valproic acid (sodium valproate)α Albendazole Ivermectin Levamisole Mebendazole Niclosamide Praziquantel Pyrantel ... clavulanic acid) Ampicillin Benzathine benzylpenicillin Benzylpenicillin Cefalexin Cefazolin Chloramphenicol Clindamycin ...
https://en.wikipedia.org/wiki/WHO_Model_List_of_Essential_Medicines_for_Children
IsoparIsopar
... may refer to: Isopar, a formulation of the anti-tuberculosis drugs isoniazid & para-amino salicylic acid Isopar, short ...
https://en.wikipedia.org/wiki/Isopar
Tuberculosis managementTuberculosis management
... p-aminosalicylic acid); or, it may have toxic side-effects (e.g., cycloserine); or it may be effective, but unavailable in many ...
https://en.wikipedia.org/wiki/Tuberculosis_management
CidofovirCidofovir
... aminosalicylic acid, etc.) are also withheld. Its active metabolite, cidofovir diphosphate, inhibits viral replication by ...
https://en.wikipedia.org/wiki/Cidofovir
Availability of Streptomycin and Para-Aminosalicylic Acid -- United StatesAvailability of Streptomycin and Para-Aminosalicylic Acid -- United States
Availability of Streptomycin and Para-Aminosalicylic Acid -- United States Since April 1992, CDC has distributed streptomycin ... Until further notice, CDC will continue to supply para-aminosalicylic acid under a separate IND agreement. ... Additional information concerning streptomycin or para-aminosalicylic acid is available from CDCs Drug Service, Scientific ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00021015.htm
Pediatric Crohn Disease Medication: 5-Aminosalicylic Acid Derivatives, Corticosteroids, Immunosuppressants, Monoclonal...Pediatric Crohn Disease Medication: 5-Aminosalicylic Acid Derivatives, Corticosteroids, Immunosuppressants, Monoclonal...
5-Aminosalicylic Acid Derivatives. Class Summary. 5-ASA derivatives are used to treat mild-to-moderate Crohn disease and to ... Akobeng AK, Gardener E. Oral 5-aminosalicylic acid for maintenance of medically-induced remission in Crohns Disease. Cochrane ... Agent classes used include 5-aminosalicylic acid (5-ASA) derivatives, corticosteroids, immunosuppressive agents, biologic ... Mesalamine inhibits leukotriene biosynthesis via the lipoxygenase pathway of arachidonic acid metabolism and interferes with ...
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Detection of 5-Aminosalicylic Acid (5-ASA) in Rectal Mucosal Biopsies | Clinical Science | Portland PressDetection of 5-Aminosalicylic Acid (5-ASA) in Rectal Mucosal Biopsies | Clinical Science | Portland Press
Detection of 5-Aminosalicylic Acid (5-ASA) in Rectal Mucosal Biopsies A. Ireland; A. Ireland ... A. Ireland, J.D. Priddle, D.P. Jewell; Detection of 5-Aminosalicylic Acid (5-ASA) in Rectal Mucosal Biopsies. Clin Sci (Lond) 1 ...
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Paser (aminosalicylic acid) dose, indications, adverse effects, interactions... from PDR.netPaser (aminosalicylic acid) dose, indications, adverse effects, interactions... from PDR.net
Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis. It has been postulated that aminosalicylic acid ... of aminosalicylic acid. Lower serum concentrations observed with the delayed release aminosalicylic acid products should result ... of aminosalicylic acid. Lower serum concentrations observed with the delayed release aminosalicylic acid products should result ... of aminosalicylic acid. Lower serum concentrations observed with the delayed release aminosalicylic acid products should result ...
https://pdr.net/drug-summary/Paser-aminosalicylic-acid-262
Aminosalicylic Acids - McMaster Experts
Putting Rectal 5-Aminosalicylic Acid in Its Place: The Role in Distal Ulcerative Colitis Academic Article ... Criteria of purity and stability of the sodium salt of p-aminosalicylic acid (PAS). 3. Coloration of water solutions. Diagram ... Purity criteria and stability of sodium salt of p-aminosalicylic acid (PAS). IV. Effect of impurities on the stability. ... Purity criteria and stability of sodium salt of p-aminosalicylic acid (PAS). V. Effect of impurities on the stability. ...
https://experts.mcmaster.ca/display/vocab-mesh-aminosalicylic-acids
Pneumotox » Drug » Mesalazine-Mesalamine-5-aminosalicylic acid-5-ASA » V.b - Eosinophilic pleural effusion
The Pneumotox website uses cookies. By accessing or using our website, you consent to the collection, use and disclosure of the garnered information in accordance with our privacy policy. ...
https://www.pneumotox.com/effect/view/195/mesalazine-mesalamine-5-aminosalicylic-acid-5-asa/553/eosinophilic-pleural-effusion
4-Aminosalicylic Acid | CRO Laboratories4-Aminosalicylic Acid | CRO Laboratories
4-Aminosalicylic Acid. Synonyms. 4-Amino-2-hydroxy-benzoic Acid; 3-Hydroxy-4-carboxyaniline; 4-ASA; 4-Amino-2-hydroxybenzoic ... Para-aminosalicylic Acid; Paramycin; Parasal; Parasalicil; Parasalindon; Pasa; Pasalon; Pasara; Pasem; Paser; Pasmed; Pasnodia ... Acid; 4-Carboxy-3-hydroxyaniline; Amino-PAS; Apacil; Apas; Deapasil; Entepas; Gabbropas; Monopass; NSC 2083; NSC 211698; ...
https://crolaboratories.com/product/4-aminosalicylic-acid/
Chronotherapy of 5-Aminosalicylic Acid in Ulcerative ColitisChronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis
Clinical trial for Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis. ... Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis Ulcerative Colitis Clinical Trial ... Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis: A Randomized Crossover Trial ... Amino Acids in Ileal Pouch-anal Anastomosis for Ulcerative Colitis N/A. ...
https://inclinicaltrials.com/ulcerative-colitis/NCT05213234/
Treatment of Tuberculosis and Tuberculosis Infection in Adults and ChildrenTreatment of Tuberculosis and Tuberculosis Infection in Adults and Children
Para-aminosalicylic Acid. Para-aminosalicylic acid is a bacteriostatic antituberculosis drug. The usual therapeutic dose is ... Para-aminosalicylic Acid. Ethionamide. Cycloserine. Capreomycin. Kanamycin. Thiacetazone. POTENTIALLY EFFECTIVE DRUGS THAT HAVE ... aminosalicylic acid is rapidly excreted. The delayed release granules should be given with acidic food or drink, such as orange ... hypersensitivity Para-aminosalicylic acid Tablets: 500 mg, 1 g 150 mg/kg, PO 12 g Gastrointestinal Hepatic enzymes Bulk powder ...
https://wonder.cdc.gov/wonder/prevguid/p0000413/p0000413.asp
Biopharmaceutical evaluation of salicylazosulfanilic acid as a novel colon-targeted prodrug of 5-aminosalicylic acid<...
Biopharmaceutical evaluation of salicylazosulfanilic acid as a novel colon-targeted prodrug of 5-aminosalicylic acid. J. Drug ... Biopharmaceutical evaluation of salicylazosulfanilic acid as a novel colon-targeted prodrug of 5-aminosalicylic acid. In: J. ... Biopharmaceutical evaluation of salicylazosulfanilic acid as a novel colon-targeted prodrug of 5-aminosalicylic acid. / ... title = "Biopharmaceutical evaluation of salicylazosulfanilic acid as a novel colon-targeted prodrug of 5-aminosalicylic acid", ...
https://okayama.pure.elsevier.com/en/publications/biopharmaceutical-evaluation-of-salicylazosulfanilic-acid-as-a-no
Results of search for 'su:{p-Aminosalicylic acid}' › WHO HQ Library catalog
Text; Format: print Publication details: Geneva : World Health Organization, 1957Online access: Click here to access online Availability: Items available for loan: WHO HQ (2)Call number: HQ SERIAL, ... Not available: WHO HQ: Withdrawn (1). ...
https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7Bp-Aminosalicylic%20acid%7D
4-Aminosalicylic Acid - DOAJ - Summarized by Plex.page | Research | Summarization4-Aminosalicylic Acid - DOAJ - Summarized by Plex.page | Research | Summarization
Synthesis of a novel PEGylated colon-specific azo-based 4- aminosalicylic acid prodrug. Objective: 4-aminosalicylic acid is an ... propenoic acid. The structures of the co-crystalline adducts of 3,5-dinitrobenzoic acid with 4-aminosalicylic acid, the 1:1 ... Crystal structures and hydrogen bonding in the co-crystalline adducts of 3,5-dinitrobenzoic acid with 4-aminosalicylic acid and ... A microporous hydrogel was developed making use of salt alginate and 4-aminosalicylic acid. Additonal carboxyl and hydroxyl ...
https://scholar.plex.page/4-Aminosalicylic_Acid-DOAJ
5-Aminosalicylic acid (89-57-6) | Chemical Effects in Biological Systems5-Aminosalicylic acid (89-57-6) | Chemical Effects in Biological Systems
Genetic Toxicity Evaluation of 5-Aminosalicylic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 759488 Summary ... 5-Aminosalicylic acid (89-57-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National ... Genetic Toxicity Evaluation of 5-Aminosalicylic Acid (89-57-6) in Micronucleus Study 805434 in B6C3F1 Mice Summary and ... An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 5-Aminosalicylic acid (89-57-6). ...
https://cebs.niehs.nih.gov/cebs/test_article/89-57-6
Folic acid - test: MedlinePlus Medical EncyclopediaFolic acid - test: MedlinePlus Medical Encyclopedia
This article discusses the test to measure the amount of folic acid in the blood. ... Folic acid is a type of B vitamin. ... Aminosalicylic acid. *Birth control pills. *Estrogens. * ... Folic acid is a type of B vitamin. This article discusses the test to measure the amount of folic acid in the blood. ... Folic acid helps form red blood cells and produce DNA that stores genetic codes. Taking the right amount of folic acid before ...
https://medlineplus.gov/ency/article/003686.htm
Current and future treatments for irritable bowel syndrome associated with diarrhea - Mayo ClinicCurrent and future treatments for irritable bowel syndrome associated with diarrhea - Mayo Clinic
Mast cell stabilizers and 5-aminosalicylic acid (5-ASA). Gastroenteritis precedes IBS-D in about 25 percent of people. Two anti ... Bile acid binders. Roughly 30 percent of people with IBS-D have diagnosed bile acid malabsorption, and for this subset of ... and bile acids and short-chain fatty acids, which may stimulate serotonin (5-HT) release and increase colonic permeability and ... bile acid sequestration may relieve the cholerrheic effect of bile acids. Some evidence suggests that certain genetic variants ...
https://www.mayoclinic.org/medical-professionals/digestive-diseases/news/current-and-future-treatments-for-ibs-d/mac-20429499
IMSEAR at SEARO: Oxidation of red cell glutathione and haemoglobin by stored enteric coated para-amino salicylic acid
Oxidation of red cell glutathione and haemoglobin by stored enteric coated para-amino salicylic acid. Union of Burma Journal of ... Oxidation of red cell glutathione and haemoglobin by stored enteric coated para-amino salicylic acid. ...
https://imsear.searo.who.int/handle/123456789/126734
Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control. | Eur J Pharm Sci;156: 105599, 2021 Jan...Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control. | Eur J Pharm Sci;156: 105599, 2021 Jan...
Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control. Solvent dependent 4-aminosalicylic acid- ... 4-aminosalicylic acid; Co-crystal; Hansen solubility parameters; Multi-drug; Polymorph; Sulfamethazine ... There have been two reported polymorphic forms of the 4-aminosalicylic acid-sulfamethazine co-crystals. These forms were found ...
https://pesquisa.bvsalud.org/hansen/resource/pt/mdl-33075464
Nitrate/Nitrite Toxicity: Clinical Assessment - Evaluation | Environmental Medicine | ATSDRNitrate/Nitrite Toxicity: Clinical Assessment - Evaluation | Environmental Medicine | ATSDR
p-Aminosalicylic acid. *Bactericide (tuberculostatic). *Naphthalene. *Mothballs. *Copper sulfate. *Fungicide for plants ...
https://www.atsdr.cdc.gov/csem/nitrate-nitrite/clinical_assessment.html
Human acetyltransferase polymorphismsHuman acetyltransferase polymorphisms
Aminosalicylic Acid / metabolism * Arylamine N-Acetyltransferase / genetics* * Arylamine N-Acetyltransferase / metabolism * ...
https://pubmed.ncbi.nlm.nih.gov/9202739/
IMSEAR at SEARO: Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Prednisolone and 5-Amino...
The present work carries an analytical method development of prednisolone and 5- amino salicylic acid in tablet dosage form. ... Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Prednisolone and 5-Amino Salicylic Acid in ... Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Prednisolone and 5-Amino Salicylic Acid in ... absorption ratio method for the simultaneous determination of the prednisolone and 5-amino salicylic acid. Both the drugs are ...
https://imsear.searo.who.int/handle/123456789/151326?mode=full
Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy Medication: Nonsteroidal Anti-inflammatory Drugs, 5...
5-Aminosalicylic Acid Derivatives. Class Summary. 5-Aminosalicylic acid derivatives inhibit prostaglandin synthesis and reduce ...
https://www.staging.medscape.com/answers/332945-70125/what-are-the-goals-of-drug-treatment-for-ankylosing-spondylitis-as-and-undifferentiated-spondyloarthropathy-uspa
Listing of Drugs Currently Regulated as New Drugs (The New Drugs List) - Canada.caListing of Drugs Currently Regulated as New Drugs (The New Drugs List) - Canada.ca
Aminocaproic Acid. Aminoglutethemide. Aminophylline. suppository, oral modified release preparation. Aminosalicylic Acid (5-). ... Amino acids are present in a protein configuration are not considered to be drugs; only when isolated and present as a single ... This substance, an omega-3 fatty acid, is present in fish oil and other food substances. It is to be regarded as a new drug ... Amino Acids. [Tryptophan, Arginine, Ornithine, Phenylalanine, Tyrosine, Lysine, Carnitine, Methionine (other than Lipotropic ...
https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/applications-submissions/guidance-documents/listing-drugs-currently-regulated-new-drugs.html
Tuberculosis (TB) Treatment & Management: Approach Considerations, Treatment During Pregnancy, Treatment in ChildrenTuberculosis (TB) Treatment & Management: Approach Considerations, Treatment During Pregnancy, Treatment in Children
Para-aminosalicylic acid Successful MDR-TB treatment is more likely in association with such factors as lower prior patient ... Direct nucleic acid amplification testing improves TB diagnosis. Medscape Medical News. June 6, 2013. [Full Text]. ... Numerous acid-fast bacilli (pink) from a bronchial wash are shown on a high-power oil immersion. ... Guideline] Updated guidelines for the use of nucleic acid amplification tests in the diagnosis of tuberculosis. MMWR Morb ...
https://emedicine.medscape.com/article/230802-treatment
Synera (Lidocaine and Tetracaine): Uses, Dosage, Side Effects, Interactions, WarningSynera (Lidocaine and Tetracaine): Uses, Dosage, Side Effects, Interactions, Warning
dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides. Antimalarials. chloroquine, primaquine. Anticonvulsants. ... SYNERA is also contraindicated in patients with para-aminobenzoic acid (PABA) hypersensitivity and in patients with a known ... Primary metabolites of tetracaine include para-aminobenzoic acid and diethylaminoethanol, both of which have an unspecified ... primarily alpha-1-acid glycoprotein. At much higher plasma concentrations (1 to 4 mcg/mL of free base) the plasma protein ...
https://www.rxlist.com/synera-drug.htm
Sulfasalazine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiSulfasalazine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
However, oral sulfasalazine inhibits the absorption and metabolism of folic acid which may interfere with folic acid ... folic acid. This is not a complete list of sulfasalazine drug interactions. Ask your doctor or pharmacist for more information. ... Aminosalicylic acid and similar agents. Side Effects of Sulfasalazine. Back to Top ... supplementation and diminish the effect of periconceptional folic acid supplementation that has been shown to decrease the risk ...
https://www.rxwiki.com/sulfasalazine/
Salicylic acidMesalazineDerivativesFolic acidSulfasalazineAmikacinSynthesisMetabolitesSulfamethazineStreptomycinPyrazinamideMesalamineAcetylsalicylic acidInflammatoryOralDrugsEvaluationBacilliConclusionsRenalMalabsorptionEsterPatientsGastrointestinalSaltPageGroup
Salicylic acid5
  • IMSEAR at SEARO: Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Prednisolone and 5-Amino Salicylic Acid in Tablet Dosage form. (who.int)
  • The present work carries an analytical method development of prednisolone and 5- amino salicylic acid in tablet dosage form. (who.int)
  • The method is based upon Q - absorption ratio method for the simultaneous determination of the prednisolone and 5-amino salicylic acid. (who.int)
  • All preparations containing salicylic acid and derivatives are classified in N02BA - Salicylic acid and derivatives, as it is difficult to differentiate between use of salicylates in rheumatic conditions and other therapeutic uses. (whocc.no)
  • Salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid). (medscape.com)
Mesalazine4
  • Objective: 4-aminosalicylic acid is an isomer of mesalazine that has lately been revealed to be effective against inflammatory digestive tract illness, and extra especially, ulcerative colitis. (plex.page)
  • Treatment of the disease includes 5-aminosalicylic acid drugs such as mesalazine at first-line therapy, with a possible association of corticosteroids. (lww.com)
  • For example, 5-aminosalicylic acid (mesalazine) improves replication fidelity in HCT-116 CRC cells ( 17 , 18 ). (spandidos-publications.com)
  • Mesalazine and sulfasalazine are anti-inflammatory agents from the 5-aminosalicylic acid (5-ASA) group which are commonly used for the treatment of inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD). (npra.gov.my)
Derivatives1
  • 5-Aminosalicylic acid derivatives inhibit prostaglandin synthesis and reduce the inflammatory response to tissue injury. (medscape.com)
Folic acid7
  • Folic acid is a type of B vitamin. (medlineplus.gov)
  • This article discusses the test to measure the amount of folic acid in the blood. (medlineplus.gov)
  • Your health care provider may tell you to stop taking any drugs that may interfere with test results, including folic acid supplements. (medlineplus.gov)
  • This test is done to check for folic acid deficiency . (medlineplus.gov)
  • Folic acid helps form red blood cells and produce DNA that stores genetic codes. (medlineplus.gov)
  • Taking the right amount of folic acid before and during pregnancy helps prevent neural tube defects, such as spina bifida. (medlineplus.gov)
  • Women who are pregnant or planning to become pregnant should take at least 600 micrograms (mcg) of folic acid every day. (medlineplus.gov)
Sulfasalazine1
  • Mechanism of action of sulfasalazine:- The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfa. (blogspot.com)
Amikacin2
  • A regimen with rifabutin, ciprofloxacin, amikacin, para-aminosalicylic acid, and clofazimine led to a short phase of negative sputum cultures, but a chest X ray showed no improvement. (cdc.gov)
  • Later, additional resistance to para-aminosalicylic acid and amikacin was documented. (cdc.gov)
Synthesis3
  • 6-Mercaptopurine (6-MP) and its prodrug, azathioprine, are purine analogues that interfere with protein synthesis and nucleic acid metabolism. (medscape.com)
  • LX-1031 is a tryptophan hydroxylase inhibitor that reduces local 5-HT synthesis and 5-hydroxyindoleacetic acid (5-HIAA) excretion. (mayoclinic.org)
  • Rifaximin acts by inhibiting RNA synthesis in susceptible bacteria by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. (blogspot.com)
Metabolites1
  • Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase and lipoxygenase pathways, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon. (pediatriconcall.com)
Sulfamethazine3
  • In this research study, high-pressure homogenization and high-power ultrasound were utilized to prepare nano-sized cocrystals of 4-aminosalysilic acid and sulfamethazine in order to develop distinctions in between both techniques in terms of cocrystal dimension, morphology, polymorphic form, and dissolution rate improvement. (plex.page)
  • Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control. (bvsalud.org)
  • There have been two reported polymorphic forms of the 4-aminosalicylic acid - sulfamethazine co-crystals. (bvsalud.org)
Streptomycin2
  • Additional information concerning streptomycin or para-aminosalicylic acid is available from CDC's Drug Service, Scientific Resources Program, National Center for Infectious Diseases, telephone (404) 639-3670. (cdc.gov)
  • Isoniazid, a drug known as para-aminosalicylic acid, a derivative of streptomycin. (killtenrats.com)
Pyrazinamide1
  • Patients with TB who are receiving pyrazinamide should undergo baseline and periodic serum uric acid assessments, and patients with TB who are receiving long-term ethambutol therapy should undergo baseline and periodic visual acuity and red-green color perception testing. (medscape.com)
Mesalamine3
  • Mesalamine inhibits leukotriene biosynthesis via the lipoxygenase pathway of arachidonic acid metabolism and interferes with myeloperoxidase activity and reactive oxygen species. (medscape.com)
  • The active ingredient in ROWASA® (Mesalamine) Rectal Suspension Enema, a disposable (60 mL) unit, is mesalamine, also known as 5-aminosalicylic acid (5-ASA). (druglib.com)
  • Topical mesalamine (5-aminosalicylic acid [5-ASA]) inhibits inflammatory processes in UP. (druglib.com)
Acetylsalicylic acid1
  • oral preparations containing 80 mg or less per dosage unit and intended for pediatric use or rectal preparations containing 150 mg or less per dosage unit, in package sizes containing no more than 1.92 g of acetylsalicylic acid. (napra.ca)
Inflammatory1
  • AST-120 is a preparation consisting of spherical carbon particles that adsorb bacterial toxins, inflammatory mediators and bile acid products and prevent them from entering systemic circulation. (mayoclinic.org)
Oral1
  • That oral aminosalicylates (active ingredient 5-aminosalicylic acid [5-ASA]) are not an effective treatment option for maintenance therapy in Crohn's disease has been robustly demonstrated. (ueg.eu)
Drugs1
  • Gabapentin is a member of the anticonvulsant class of drugs known as gamma-aminobutyric acid (gaba) agonists. (killtenrats.com)
Evaluation2
  • Kurosaki, Y 1994, ' Biopharmaceutical evaluation of salicylazosulfanilic acid as a novel colon-targeted prodrug of 5-aminosalicylic acid ', J. Drug Targeting , vol. 2, no. 2, pp. 123-131. (elsevier.com)
  • Genetic Toxicity Evaluation of 5-Aminosalicylic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
Bacilli2
  • Gram-positive, pleomorphic non-spore-forming, non-acid-fast anaerobic or microaerophilic bacilli of the genus Actinomyces and the order Actinomycetales cause actinomycosis. (medscape.com)
  • A tuberculin skin test was positive (12 mm), acid-fast bacilli were detected in gastric aspirates, and two sputum cultures were positive for TB. (cdc.gov)
Conclusions1
  • An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 5-Aminosalicylic acid (89-57-6). (nih.gov)
Renal1
  • Aminosalicylic acid is contraindicated in patients with end-stage renal disease. (pdr.net)
Malabsorption1
  • Roughly 30 percent of people with IBS-D have diagnosed bile acid malabsorption, and for this subset of patients, bile acid sequestration may relieve the cholerrheic effect of bile acids. (mayoclinic.org)
Ester1
  • Moreover, NCX-4040 (an NO releasing aspirin, 2-(acetyloxy)benzoic acid 4-[(nitrooxy)methyl]phenyl ester) can also suppress microsatellite instability ( 19 ) and sensitise human colon cancer cells, cultured in vitro and transplanted in vivo in mice, to oxaliplatin ( 20 ). (spandidos-publications.com)
Patients2
  • Patients with hepatic disease may not tolerate aminosalicylic acid as well as those without hepatic disease. (pdr.net)
  • N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis. (cdc.gov)
Gastrointestinal1
  • Certain factors that alter gastrointestinal function can contribute to IBS symptoms, including stress, prior gastroenteritis, changes in the gut microbiome, and bile acids and short-chain fatty acids, which may stimulate serotonin (5-HT) release and increase colonic permeability and motility. (mayoclinic.org)
Salt2
  • Criteria of purity and stability of sodium salt of p-aminosalicylic acid (PAS). (mcmaster.ca)
  • A microporous hydrogel was developed making use of salt alginate and 4-aminosalicylic acid. (plex.page)
Page1
  • Voir page 493 le re´sume´ en franc¸ais. (who.int)
Group1
  • A group of 2-hydroxybenzoic acids that can be substituted by amino groups at any of the 3-, 4-, 5-, or 6-positions. (bvsalud.org)
Treatment of Tuberculosis American Thoracic Society, CDC, and Infectious Diseases Society of America
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Vitamin B12 level: MedlinePlus Medical Encyclopedia
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Cyanocobalamin Injection: MedlinePlus Drug Information
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Current and future treatments for irritable bowel syndrome associated with diarrhea - Mayo Clinic
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Colon Capsule Endoscope for Ulcerative Colitis
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Nitrate/Nitrite Toxicity: Clinical Assessment - Evaluation | Environmental Medicine | ATSDR
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Appendix Figure - Clonal Expansion of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, Japan - Volume 16,...
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Pediatric Aphthous Ulcers Medication: Topical anesthetics, Antihistamines, Topical corticosteroids, Local corticosteroid...
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Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Facilities, 1994
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Ulcerative Colitis in Children Treatment & Management: Approach Considerations, Treatment of Mild Disease, Treatment of...
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Pediatric Aseptic Meningitis Medication: Antibiotics, Antiviral Agents, Antitubercular Agents
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(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
Pressure Urticaria Medication: Antihistamines, 2nd Generation, Antihistamines, 1st Generation, Monoclonal Antibodies,...
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(emedicine.medscape.com)