Phenmetrazine
Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. (1/4)
BACKGROUND: Coadministration of phentermine and fenfluramine (phen/fen) effectively treats obesity and possibly addictive disorders. The association of fenfluramine and certain other anorexic agents with serious side effects, such as cardiac valvulopathy and primary pulmonary hypertension (PPH), limits the clinical utility of these drugs. Development of new medications that produce neurochemical effects like phen/fen without causing unwanted side effects would be a significant therapeutic breakthrough. METHODS AND RESULTS: We tested the hypothesis that fenfluramine (and other anorexic agents) might increase the risk of PPH through interactions with serotonin (5-HT) transporters. Because 5-HT transporter proteins in the lung and brain are identical, we examined, in rat brain, the effects of selected drugs on 5-HT efflux in vivo and monoamine transporters in vitro as a generalized index of transporter function. Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard. CONCLUSIONS: We speculate that medications that are 5-HT transporter substrates get translocated into pulmonary cells where, depending on the degree of drug retention, their intrinsic drug toxicity, and individual susceptibility, PPH could develop as a response to high levels of these drugs or metabolites. Emerging evidence suggests that it is possible to develop transporter substrates devoid of adverse side effects. Such medications could have therapeutic application in the management of obesity, drug dependence, depression, and other disorders. (+info)Delayed onset of pulmonary hypertension associated with an appetite suppressant, mazindol: a case report. (2/4)
The use of the appetite suppressant agents aminorex and fenfluramine derivatives has been reported as a risk factor for the development of pulmonary hypertension. A 29-year-old female developed pulmonary hypertension suspected to be due to an amphetamine-like appetite suppressant agent, mazindol ((+/-)-5-(p-chlorophenyl)-2,5-dihydro-3H-imidazo [2,1-a] isoindol-5-ol). She was admitted to Sapporo Medical University Hospital with dyspnea due to severe pulmonary hypertension. Twelve months prior to admission, she had taken mazindol continuously for a period of 10 weeks. As yet, her pulmonary hypertension has not completely improved. This is the first reported case of mazindol-associated pulmonary hypertension, which developed after a long latent interval, and it suggests that mazindol is also a risk factor for the development of pulmonary hypertension, making long-term follow-up necessary for patients taking this anorectic agent. (+info)Drug-induced pulmonary hypertension? (3/4)
Of 40 patients with obstructive pulmonary hypertension studied in Basle, Switzerland, during the period 1966-68, 32 had been taking an anorectic drug, aminorex fumarate. Rapidly progressing exertional dyspnoea, central chest pain, and syncope on effort were characteristic features. The absence of the usual causes of pulmonary vascular disease seems to suggest the possibility of drug-induced pulmonary hypertension. Further studies are necessary, however, to clarify the role of aminorex fumarate in this condition. (+info)Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. (4/4)
BACKGROUND: The appetite suppressant aminorex fumarate is thought to have caused an epidemic of pulmonary hypertension in Europe in the 1960s. More recently, pulmonary hypertension has been described in some patients taking other amphetamine-like, anorexic agents: fenfluramine and its d-isomer, dexfenfluramine. No mechanism has been demonstrated that might account for the association between anorexic drugs and pulmonary hypertension. METHODS AND RESULTS: Using the whole-cell, patch-clamp technique, we found that aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in smooth muscle cells taken from the small resistance pulmonary arteries of the rat lung. Dexfenfluramine causes reversible membrane depolarization in these cells. These actions are similar to those of hypoxia, which initiates pulmonary vasoconstriction by inhibiting a potassium current in pulmonary vascular smooth muscle. In the isolated, perfused rat lung, aminorex, fenfluramine, and dexfenfluramine induce a dose-related increase in perfusion pressure. When the production of endogenous NO is inhibited by N-nitro-L-arginine methyl ester, the pressor response to dexfenfluramine is greatly enhanced. CONCLUSIONS: These observations indicate that anorexic agents, like hypoxia, can inhibit potassium current, cause membrane depolarization, and stimulate pulmonary vasoconstriction. They suggest one mechanism that could be responsible for initiating pulmonary hypertension in susceptible individuals. It is possible that susceptibility is the result of the reduced production of an endogenous vasodilator, such as NO, but this remains speculative. (+info)
Aminorex
Ho EN, Leung DK, Leung GN, Wan TS, Wong AS, Wong CH, Soma LR, Rudy JA, Uboh C, Sams R (April 2009). "Aminorex and rexamino as ... Aminorex, in the 2-amino-5-aryl oxazoline class, was developed by McNeil Laboratories in 1962. It is closely related to 4- ... Aminorex effects have been attributed to the release of catecholamines. It can be produced as a metabolite of the worming ... Jan 1991). "Aminorex to fen/phen - An epidemic foretold". Circulation. 99 (1): 156-161. doi:10.1161/01.CIR.99.1.156. ISSN 0009- ...
2C-B-aminorex
... (2C-B-AR) is a recreational designer drug with psychedelic effects. It is a substituted aminorex derivative which ... 2C-B 2C-B-PP BOB (psychedelic) 4,4'-DMAR 4'-Fluoro-4-methylaminorex List of aminorex analogues Evans-Brown M, Gallegos A, ...
List of aminorex analogues
This is a list of aminorex analogues. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was ... Aminorex and pulmonary hypertension. A review. Cor Vasa. 1985;27(2-3):160-71. PMID 3928246 Davis FT, Brewster ME. A fatality ... Recreational use of aminorex and pulmonary hypertension. Chest. 2000 Nov;118(5):1496-7. PMID 11083709 Meririnne E, Kajos M, ... 1995 Jun-Jul;51(2-3):375-8. PMID 7667356 Zheng Y, Russell B, Schmierer D, Laverty R. The effects of aminorex and related ...
List of dopaminergic drugs
Aminorex • Clominorex • Cyclazodone • Fenozolone • Fluminorex • Pemoline • Thozalinone Phenethylamines (also amphetamines, ...
Brazilian Controlled Drugs and Substances Act
AMINOREX 2. ANFEPRAMONE (DIETILPROPIONA) 3. FEMPROPOREX 4. FENDIMETRAZINE 5. FENTERMIN 6. MAZINDOL 7. MEFENOREX 1. ACEPROMAZINE ...
4'-Fluoro-4-methylaminorex
2C-B-aminorex 3-Fluorophenmetrazine 4-Fluoroamphetamine 4,4'-DMAR Fluminorex MDMAR List of aminorex analogues Fabregat-Safont D ... Maier J, Mayer FP, Brandt SD, Sitte HH (October 2018). "DARK Classics in Chemical Neuroscience: Aminorex Analogues". ACS ... 4'-Fluoro-4-methylaminorex (4-FPO) is a recreational designer drug from the substituted aminorex family, with stimulant effects ... "Characterization of a recently detected halogenated aminorex derivative: para-fluoro-4-methylaminorex (4'F-4-MAR)". Scientific ...
Anorectic
This was the case with aminorex in the 1960s, and again in the 1990s with fenfluramine (see: Fen-phen). Likewise, association ... Fishman, A. P. (1999). "Aminorex to Fen/Phen : An Epidemic Foretold". Circulation. 99 (1): 156-61. doi:10.1161/01.cir.99.1.156 ...
4-Methylaminorex
Zheng Y, Russell B, Schmierer D, Laverty R (January 1997). "The effects of aminorex and related compounds on brain monoamines ... Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA (November 2000). "Recreational use of aminorex and pulmonary hypertension ... 1985), the results suggest that the aminorex compounds except 4S,5S-dimethylaminorex, unlike MDMA or fenfluramine, are not ... Young R (May 1992). "Aminorex produces stimulus effects similar to amphetamine and unlike those of fenfluramine". Pharmacology ...
MDMAR
2C-B-aminorex 4,4'-DMAR 4'-Fluoro-4-methylaminorex 5-MAPB MDMA Methylenedioxyphenmetrazine List of aminorex analogues ... Maier J, Mayer FP, Brandt SD, Sitte HH (October 2018). "DARK Classics in Chemical Neuroscience: Aminorex Analogues". ACS ... 3',4'-Methylenedioxy-4-methylaminorex (MDMAR) is a recreational designer drug from the substituted aminorex family, with ...
Anti-obesity medication
Fishman AP (1999). "Aminorex to fen/phen: an epidemic foretold". Circulation. 99 (1): 156-161. doi:10.1161/01.CIR.99.1.156. ...
Chlorphentermine
Aminorex Cericlamine Cloforex Clortermine Etolorex Fenfluramine Methylenedioxyphentermine Phentermine Gylys JA, Hart JJ, Warren ... Rothman RB, Ayestas MA, Dersch CM, Baumann MH (August 1999). "Aminorex, fenfluramine, and chlorphentermine are serotonin ... as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex ...
Levamisole
... meaning that both humans and dogs also metabolize levamisole into aminorex., though it is unclear whether plasma aminorex is ... Ho EN, Leung DK, Leung GN, Wan TS, Wong AS, Wong CH, Soma LR, Rudy JA, Uboh C, Sams R (April 2009). "Aminorex and rexamino as ... pp 213-222 Bertol E, Mari F, Milia MG, Politi L, Furlanetto S, Karch SB (July 2011). "Determination of aminorex in human urine ... Blood samples following oral administration of levamisole out to 172 hr post-dose did not demonstrate any plasma aminorex ...
Deadly Medicines and Organised Crime
The list here includes Vioxx, Bextra, Aminorex, Pondimin, Redux, Avandia, and Rezulin. Gøtzsche devotes two chapters on the ...
Difemetorex
Circulatory effects of the anorectic Diphemethoxidine compared with the effects of Amphetamine and Aminorex]". Archives ... of the acid-base equilibrium by the anorectic diphemethoxidine in comparison with the effect of amphetamine and aminorex]". ...
Picilorex
α-PHP α-PHPP Pyrovalerone Prolintane Rolicyclidine (PCPy) MDPV List of aminorex analogues Substituted phenylmorpholine PubChem ...
Clominorex
4-Methylaminorex Aminorex Cyclazodone Fenozolone Fluminorex Pemoline Thozalinone v t e (Articles with short description, Short ... Clominorex is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline. It was ...
Fluminorex
... is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline. It was ... 4'-Fluoro-4-methylaminorex 4-Methylaminorex Aminorex Clominorex Cyclazodone Fenozolone Pemoline Thozalinone US Patent 3278382 ...
Serotonin releasing agent
Fenfluramine, chlorphentermine, and aminorex, which are also amphetamines and relatives, were formerly used as appetite ...
List of benzimidazole opioids
25-NB Arylcyclohexylamine List of aminorex analogues List of benzodiazepines List of fentanyl analogues List of phenyltropanes ...
BOB (psychedelic)
BOD BOH BOHD Bk-2C-B β-Methyl-2C-B 2C-B-aminorex Phenethylamine BOB Entry in PiHKAL "UK Misuse of Drugs act 2001 Amendment ...
Substituted phenylmorpholine
Substituted amphetamine Substituted benzofuran Substituted cathinone Substituted methylenedioxyphenethylamine List of aminorex ...
5-HT2B receptor
MDMA MDA MEM Pergolide Cabergoline Norfenfluramine Chlorphentermine Aminorex Bromo-dragonfly DMT 5-MeO-DMT LSD - About equal ...
4,4'-Dimethylaminorex
2C-B-aminorex 4'-Fluoro-4-methylaminorex 4-Methylphenmetrazine MDMAR List of aminorex analogues "2021 - Placement of 4,4'-DMAR ... is a psychostimulant and entactogen designer drug related to aminorex, 4-methylaminorex, and pemoline. It was first detected in ...
Pemoline
... is a member of the 4-oxazolidinone class and is structurally related to other members of the class including aminorex ...
2C-B-DRAGONFLY
2C-B-aminorex 2C-B-BUTTERFLY 2C-B-PP 2C-E-FLY DOB-FLY NBOMe-2C-B-FLY TFMFly Substituted benzofuran Zaitsu K, Katagi M, Kamata H ...
Oxazoline
... where the oxygen is replaced by sulphur Other pages Aminorex a drug bearing an oxazoline ring Wenker, H. (1938). "Syntheses ...
Opium Law
... allobarbital alprazolam amobarbital amfepramone aminorex barbital benzphetamine bromazepam brotizolam buprenorphine butalbital ...
Convention on Psychotropic Substances
... amfepramone aminorex benzphetamine etilamfetamine fencamfamine fenproporex mazindol mefenorex mesocarb pemoline phendimetrazine ...
Controlled Drugs and Substances Act
Aminorex (4,5-dihydro-5-phenyl-2-oxazolamine) and any salt thereof Etryptamine (3-(2-aminobutyl)indole) and any salt thereof ...
2C-B-PP
867-868 2C-B-aminorex 2C-B-BZP 3-Chloro-4-fluorophenylpiperazine CPD-1 ORG-12962 Quipazine Substituted piperazine Lyon RA, ...
Pulmonary Hypertension Related To Aminorex Intake Dna Injuries, Their Repair, And Carcinogenesis Soft Tissue Tumors In The Rat...
is your app Pulmonary Hypertension Related to Aminorex Intake DNA Injuries, to contact the Facebook Profile URL of User of your ... Pulmonary Hypertension Related To Aminorex Intake Dna Injuries, Their Repair, And Carcinogenesis Soft Tissue Tumors In The Rat ... Pulmonary Hypertension Related To Aminorex Intake Dna Injuries, Their Repair, And Carcinogenesis Soft Tissue Tumors In The Rat ...
Pulmonary arterial hypertension associated with fenfluramine exposure: report of 109 cases | European Respiratory Society
Of newly diagnosed patients, ,60% had a history of intake of the anorexigen aminorex fumarate 5. The fact that the epidemic ... Although this clearly indicated a role as a risk factor, the clinical course of aminorex-associated PAH was not conclusively ... Aminorex and pulmonary hypertension. A review. Cor Vasa 1985;27:160-171. ... Chronic pulmonary hypertension of vascular origin, plexogenic pulmonary arteriopathy and the appetite depressant aminorex: ...
Erowid.org: References Database
West Virginia Code
MeSH Browser
Aminorex Preferred Term Term UI T001906. Date01/01/1999. LexicalTag NON. ThesaurusID ... Aminorex Preferred Concept UI. M0000968. Registry Number. 2SH16612I9. Related Numbers. 2207-50-3. Scope Note. An amphetamine- ... Aminorex. Tree Number(s). D03.383.129.462.050. Unique ID. D000635. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D000635 ...
Search
4,4'-DMAR and MT-45 to be placed under control across the EU | www.emcdda.europa.eu
MeSH Browser
Aminorex Preferred Term Term UI T001906. Date01/01/1999. LexicalTag NON. ThesaurusID ... Aminorex Preferred Concept UI. M0000968. Registry Number. 2SH16612I9. Related Numbers. 2207-50-3. Scope Note. An amphetamine- ... Aminorex. Tree Number(s). D03.383.129.462.050. Unique ID. D000635. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D000635 ...
Pesquisa | Biblioteca Virtual em Saúde
2023 Drugs Underdosing ICD-10-CM Codes
The Professional Couriers Service Guide - Banned Drug Items - Package Tracking
1. Prohibited: General prohibition on export of opium save by the Govt. Opium and Alkaloids Factories under rule 32 of the Narcotic Drugs and Psychotropic (NDPS) Rules, 1985 or, prohibition on export of certain psychotropic substances under Rule 53 of the NDPS Rules,1985. However, the export of narcotic drugs and psychotropic substances is allowed for purposes mentioned in Chapter VII-A of the NDPS Rules, 1985.. 2. Restricted: Export of these drugs (narcotic drugs, psychotropic substances) into India is permitted under an authorization granted by the Narcotics Commissioner under Rule 58 of the NDPS Rules, 1985. As regard export of select precursor chemicals mentioned in Table below, No Objection Certificate (NOC) from the Narcotics Commissioner is required to be obtained.. ...
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DeCS
E0000163|Adriamycin|doxorubicin
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FDA UNII Code (use for SPL) FDA Preferred Term NCI Concept Code
Not Skate Board, Not Surf Board, but...
TY - BOOK
Nickel Ammonium Sulfate
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Eugeroic
... s (originally, "eugrégorique" or "eugregoric"),[1] also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of drugs that promote wakefulness and alertness.[2][3] They are used medically for the treatment of certain sleeping disorders, such as excessive daytime sleepiness and narcolepsy.[2][3] They generally have a very low addictive potential.[2][3]. ...
Cellucor Weight Loss Review - MBA
Drugs1
- Evaluations are presented for fourteen substances, including four benzodiazepines, nine designer drugs (analogues of fentanyl, tenamfetamine and aminorex), and dronabinol. (who.int)