AnatomyDiseasesChemicals and DrugsPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaNamed GroupsHealth CareGeographicals
AminorexPhenmetrazineAppetite DepressantsDexfenfluramineFenfluramineHypertension, PulmonaryPulmonary ArteryDrug and Narcotic ControlUnited States Department of AgricultureNorth CarolinaResearch SubjectsLegislation, DrugMethyltestosteroneUnited States Department of Homeland SecurityDiethylpropionPhentermineAppetiteStudents, Health Occupations4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinoneThiophenesNitrogenBupropionDesigner DrugsStructure-Activity RelationshipAmino Acids
Aminorex
An amphetamine-like anorectic agent. It may cause pulmonary hypertension.
Phenmetrazine
A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.
Appetite Depressants
Agents that are used to suppress appetite.
Dexfenfluramine
The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess any catecholamine agonist activity.
Fenfluramine
A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
Hypertension, Pulmonary
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Pulmonary Artery
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Drug and Narcotic Control
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.
United States Department of Agriculture
A cabinet department in the Executive Branch of the United States Government concerned with improving and maintaining farm income and developing and expanding markets for agricultural products. Through inspection and grading services it safeguards and insures standards of quality in food supply and production.
North Carolina
Research Subjects
Persons who are enrolled in research studies or who are otherwise the subjects of research.
Legislation, Drug
Laws concerned with manufacturing, dispensing, and marketing of drugs.
Methyltestosterone
A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL).
United States Department of Homeland Security
A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to domestic national security.
Diethylpropion
A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
Phentermine
A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Appetite
Natural recurring desire for food. Alterations may be induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.
Students, Health Occupations
Individuals enrolled in a school or formal educational program in the health occupations.
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
Inhibitor of phosphodiesterases.
Thiophenes
Nitrogen
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
Bupropion
A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.
Designer Drugs
Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.
Structure-Activity Relationship
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Amino Acids
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.

Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. (1/4)

BACKGROUND: Coadministration of phentermine and fenfluramine (phen/fen) effectively treats obesity and possibly addictive disorders. The association of fenfluramine and certain other anorexic agents with serious side effects, such as cardiac valvulopathy and primary pulmonary hypertension (PPH), limits the clinical utility of these drugs. Development of new medications that produce neurochemical effects like phen/fen without causing unwanted side effects would be a significant therapeutic breakthrough. METHODS AND RESULTS: We tested the hypothesis that fenfluramine (and other anorexic agents) might increase the risk of PPH through interactions with serotonin (5-HT) transporters. Because 5-HT transporter proteins in the lung and brain are identical, we examined, in rat brain, the effects of selected drugs on 5-HT efflux in vivo and monoamine transporters in vitro as a generalized index of transporter function. Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard. CONCLUSIONS: We speculate that medications that are 5-HT transporter substrates get translocated into pulmonary cells where, depending on the degree of drug retention, their intrinsic drug toxicity, and individual susceptibility, PPH could develop as a response to high levels of these drugs or metabolites. Emerging evidence suggests that it is possible to develop transporter substrates devoid of adverse side effects. Such medications could have therapeutic application in the management of obesity, drug dependence, depression, and other disorders.  (+info)

Delayed onset of pulmonary hypertension associated with an appetite suppressant, mazindol: a case report. (2/4)

The use of the appetite suppressant agents aminorex and fenfluramine derivatives has been reported as a risk factor for the development of pulmonary hypertension. A 29-year-old female developed pulmonary hypertension suspected to be due to an amphetamine-like appetite suppressant agent, mazindol ((+/-)-5-(p-chlorophenyl)-2,5-dihydro-3H-imidazo [2,1-a] isoindol-5-ol). She was admitted to Sapporo Medical University Hospital with dyspnea due to severe pulmonary hypertension. Twelve months prior to admission, she had taken mazindol continuously for a period of 10 weeks. As yet, her pulmonary hypertension has not completely improved. This is the first reported case of mazindol-associated pulmonary hypertension, which developed after a long latent interval, and it suggests that mazindol is also a risk factor for the development of pulmonary hypertension, making long-term follow-up necessary for patients taking this anorectic agent.  (+info)

Drug-induced pulmonary hypertension? (3/4)

Of 40 patients with obstructive pulmonary hypertension studied in Basle, Switzerland, during the period 1966-68, 32 had been taking an anorectic drug, aminorex fumarate. Rapidly progressing exertional dyspnoea, central chest pain, and syncope on effort were characteristic features. The absence of the usual causes of pulmonary vascular disease seems to suggest the possibility of drug-induced pulmonary hypertension. Further studies are necessary, however, to clarify the role of aminorex fumarate in this condition.  (+info)

Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. (4/4)

BACKGROUND: The appetite suppressant aminorex fumarate is thought to have caused an epidemic of pulmonary hypertension in Europe in the 1960s. More recently, pulmonary hypertension has been described in some patients taking other amphetamine-like, anorexic agents: fenfluramine and its d-isomer, dexfenfluramine. No mechanism has been demonstrated that might account for the association between anorexic drugs and pulmonary hypertension. METHODS AND RESULTS: Using the whole-cell, patch-clamp technique, we found that aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in smooth muscle cells taken from the small resistance pulmonary arteries of the rat lung. Dexfenfluramine causes reversible membrane depolarization in these cells. These actions are similar to those of hypoxia, which initiates pulmonary vasoconstriction by inhibiting a potassium current in pulmonary vascular smooth muscle. In the isolated, perfused rat lung, aminorex, fenfluramine, and dexfenfluramine induce a dose-related increase in perfusion pressure. When the production of endogenous NO is inhibited by N-nitro-L-arginine methyl ester, the pressor response to dexfenfluramine is greatly enhanced. CONCLUSIONS: These observations indicate that anorexic agents, like hypoxia, can inhibit potassium current, cause membrane depolarization, and stimulate pulmonary vasoconstriction. They suggest one mechanism that could be responsible for initiating pulmonary hypertension in susceptible individuals. It is possible that susceptibility is the result of the reduced production of an endogenous vasodilator, such as NO, but this remains speculative.  (+info)

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Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/BMY-14802
GR-127935GR-127935
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/GR-127935
3,4-Methylenedioxy-N-ethylamphetamine3,4-Methylenedioxy-N-ethylamphetamine
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/3,4-methylenedioxy-N-ethylamphetamine
Lysergic acid 2,4-dimethylazetidideLysergic acid 2,4-dimethylazetidide
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/Lysergic_acid_2,4-dimethylazetidide
List of Schedule I drugs (US)List of Schedule I drugs (US)
Aminorex (aminoxaphen; 2-amino-5-phenyl-2- oxazoline; or 4,5-dihydro-5-phenly-2-oxazolamine) ...
https://en.wikipedia.org/wiki/List_of_Schedule_I_drugs_(US)
25I-NBOH25I-NBOH
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/25I-NBOH
2,5-Dimethoxy-4-propylamphetamine2,5-Dimethoxy-4-propylamphetamine
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/2,5-Dimethoxy-4-propylamphetamine
6-Nitroquipazine6-Nitroquipazine
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/6-Nitroquipazine
WAY-100635WAY-100635
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/WAY-100635
5-Bromo-DMT5-Bromo-DMT
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/5-Bromo-DMT
F-15,599F-15,599
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/F-15,599
5-HT1 receptor5-HT1 receptor
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/5-HT1_receptor
4-Ethylamphetamine4-Ethylamphetamine
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/4-Ethylamphetamine
2C-T-22C-T-2
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/2C-T-2
S-15535S-15535
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/S-15535
RS-127445RS-127445
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/RS-127445
5-MAPDB5-MAPDB
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/5-MAPDB
AnorecticAnorectic
This was the case with aminorex in the 1960s, and again in the 1990s with fenfluramine (see: Fen-phen). Likewise, association ... Fishman, A. P. (1999). "Aminorex to Fen/Phen : An Epidemic Foretold". Circulation. 99 (1): 156-61. doi:10.1161/01.cir.99.1.156 ...
https://en.wikipedia.org/wiki/Anorectic
4-Methylaminorex4-Methylaminorex
List of aminorex analogues 4,4'-Dimethylaminorex Aminorex Clominorex Cyclazodone Fenozolone Fluminorex Pemoline Thozalinone US ... In the Netherlands, aminorex (4-methylaminorex is a designer drug 2014) is a List I drug of the Opium Law. It is not approved ... Zheng Y, Russell B, Schmierer D, Laverty R (January 1997). "The effects of aminorex and related compounds on brain monoamines ... Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA (November 2000). "Recreational use of aminorex and pulmonary hypertension ...
https://en.wikipedia.org/wiki/4-Methylaminorex
Anti-obesity medicationAnti-obesity medication
Alfred P. Fishman, MD (1999). "Aminorex to Fen/Phen: An Epidemic Foretold". Circulation. 99 (1): 156-161. doi:10.1161/01.CIR. ...
https://en.wikipedia.org/wiki/Anti-obesity_medication
ChlorphentermineChlorphentermine
Aminorex Cericlamine Cloforex Clortermine Etolorex Fenfluramine Methylenedioxyphentermine Phentermine Gylys JA, Hart JJ, Warren ... Rothman RB, Ayestas MA, Dersch CM, Baumann MH (August 1999). "Aminorex, fenfluramine, and chlorphentermine are serotonin ... as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex ...
https://en.wikipedia.org/wiki/Chlorphentermine
LevamisoleLevamisole
... meaning that both humans and dogs also metabolize levamisole into aminorex., though it is unclear whether plasma aminorex is ... Ho EN, Leung DK, Leung GN, Wan TS, Wong AS, Wong CH, Soma LR, Rudy JA, Uboh C, Sams R (April 2009). "Aminorex and rexamino as ... pp 213-222 Bertol E, Mari F, Milia MG, Politi L, Furlanetto S, Karch SB (July 2011). "Determination of aminorex in human urine ... Blood samples following oral administration of levamisole out to 172 hr post-dose did not demonstrate any plasma aminorex ...
https://en.wikipedia.org/wiki/Levamisole
Deadly Medicines and Organised CrimeDeadly Medicines and Organised Crime
The list here includes Vioxx, Bextra, Aminorex, Pondimin, Redux, Avandia, and Rezulin. Gøtzsche devotes two chapters on the ...
https://en.wikipedia.org/wiki/Deadly_Medicines_and_Organised_Crime
DifemetorexDifemetorex
Circulatory effects of the anorectic Diphemethoxidine compared with the effects of Amphetamine and Aminorex]". Archives ... of the acid-base equilibrium by the anorectic diphemethoxidine in comparison with the effect of amphetamine and aminorex]". ...
https://en.wikipedia.org/wiki/Difemetorex
ClominorexClominorex
... is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline. It was ... 4-Methylaminorex Aminorex Cyclazodone Fenozolone Fluminorex Pemoline Thozalinone US Patent 3278382 - 2-amino-5-aryloxazoline ...
https://en.wikipedia.org/wiki/Clominorex
Serotonin releasing agentSerotonin releasing agent
Fenfluramine, chlorphentermine, and aminorex, which are also amphetamines and relatives, were formerly used as appetite ...
https://en.wikipedia.org/wiki/Serotonin_releasing_agent
Aminorex - WikipediaAminorex - Wikipedia
Ho EN, Leung DK, Leung GN, Wan TS, Wong AS, Wong CH, Soma LR, Rudy JA, Uboh C, Sams R (April 2009). "Aminorex and rexamino as ... Aminorex, in the 2-amino-5-aryl oxazoline class, was developed by McNeil Laboratories in 1962. It is closely related to 4- ... Aminorex effects have been attributed to the release of catecholamines. It can be produced as a metabolite of the worming ... Jan 1991). "Aminorex to fen/phen - An epidemic foretold". Circulation. 99 (1): 156-161. doi:10.1161/01.CIR.99.1.156. ISSN 0009- ...
https://en.wikipedia.org/wiki/Aminorex
List of aminorex analogues - WikipediaList of aminorex analogues - Wikipedia
This is a list of aminorex analogues. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was ... Aminorex and pulmonary hypertension. A review. Cor Vasa. 1985;27(2-3):160-71. PMID 3928246 Davis FT, Brewster ME. A fatality ... Recreational use of aminorex and pulmonary hypertension. Chest. 2000 Nov;118(5):1496-7. PMID 11083709 Meririnne E, Kajos M, ... 1995 Jun-Jul;51(2-3):375-8. PMID 7667356 Zheng Y, Russell B, Schmierer D, Laverty R. The effects of aminorex and related ...
https://en.wikipedia.org/wiki/List_of_aminorex_analogues
Aminorex Quiz - The Full WikiAminorex Quiz - The Full Wiki
Question 7: Aminorex has been shown to have locomotor stimulant effects, lying midway between ________ and methamphetamine.. ... Question 8: ________ • Aminorex • Clominorex • Cyclazodone • Fenozolone • Fluminorex • Pemoline • Thozalinone. Cocaine. MDMA. 4 ... Question 3: ________ • Aminorex • Clominorex • Cyclazodone • Fenozolone • Fluminorex • Pemoline • Thozalinone. Benzylpiperazine ...
http://quiz.thefullwiki.org/Aminorex
Anorexic Agents Aminorex, Fenfluramine, and Dexfenfluramine Inhibit Potassium Current in Rat Pulmonary Vascular Smooth Muscle...Anorexic Agents Aminorex, Fenfluramine, and Dexfenfluramine Inhibit Potassium Current in Rat Pulmonary Vascular Smooth Muscle...
Aminorex and fenfluramine inhibit whole-cell IK. A, Aminorex (10 mmol/L) and 4-AP (2 mmol/L) inhibit whole-cell IK in five rat ... Chronic administration of aminorex to small numbers of monkeys,27 calves,28 and rats29 has not been found to cause pulmonary ... In dogs, three chronic studies failed to show pulmonary hypertension,29 30 31 but another study, in which aminorex was fed for ... In the aminorex (n=5) and fenfluramine (n=5) dose-response experiments, whole-cell IK were elicited by 20-mV step ...
http://circ.ahajournals.org/content/94/9/2216
Aminorex side effectsAminorex side effects
... Aminorex used to be marketed as an anorexic agent. It acts as a stimulant. One of Aminorex side effects ... Aminorex side effects Aminorex used to be marketed as an anorexic agent. It acts as a stimulant. One of Aminorex side effects ... This is our research on the alleged dangers of Aminorex / adverse effects of Aminorex and not medical advice! ... High chronic dosages of Aminorex may cause increase in Serotonin levels. Aminorex reduces appetite and may keep a person awake ...
https://owndoc.com/side_effects/narcotics/aminorex/
AminorexAminorex
... Systematic (IUPAC) name 5-phenyl-4,5-dihydro-1,3-oxazol-2-amine Identifiers CAS number 2207-50-3 ATC code ? ... Aminorex is an anorectic stimulant drug of the 2-Amino-5-Aryloxazoline class. It is closely related to the popular drug 4- ... It is, in fact, 4 times stronger than 4-methyl-aminorex and the 4-fluoro analog is listed as four times as potent again as an ... Ring-substituted aminorex derivatives have yet to be researched, but seem likely candidates for a new generation of designer ...
https://www.chemeurope.com/en/encyclopedia/Aminorex.html
4-Methyl-aminorex - wikidoc4-Methyl-aminorex - wikidoc
4-Methyl-aminorex is a stimulant drug of the 2-Amino-5-Aryloxazoline class. Commonly called "Euphoria," "U4EA,", "U4Euh", " ... The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice. Zheng Y, Russell B, Schmierer D ... Recreational use of aminorex and pulmonary hypertension. Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA. Chest. 2000 Nov ... 3. Aminorex produces stimulus effects similar to amphetamine and unlike those of fenfluramine. Young R. Pharmacol Biochem Behav ...
http://es.wikidoc.org/index.php/4-Methyl-aminorex
Niaprazine - WikipediaNiaprazine - Wikipedia
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
https://en.wikipedia.org/wiki/Niaprazine
Which drugs are no longer used or are ineffective in the treatment of obesity?Which drugs are no longer used or are ineffective in the treatment of obesity?
The history of obesity medications is replete with disasters that have taught caution in the use of this group of medicines. For example, among the initial medications used for obesity management were... more
https://www.medscape.com/answers/123702-11591/which-drugs-are-no-longer-used-or-are-ineffective-in-the-treatment-of-obesity
Category:Stimulants - Wikimedia CommonsCategory:Stimulants - Wikimedia Commons
Este texto é disponibilizado nos termos da licença Atribuição-CompartilhaIgual 3.0 Não Adaptada (CC BY-SA 3.0) da Creative Commons; pode estar sujeito a condições adicionais. Para mais detalhes, consulte as condições de utilização ...
https://commons.wikimedia.org/wiki/Category:Stimulants?uselang=pt
Federal Register :: Proposed Aggregate Production Quotas for Schedule I and II Controlled Substances and...Federal Register :: Proposed Aggregate Production Quotas for Schedule I and II Controlled Substances and...
5-HT4受體 - 维基百科，自由的百科全书5-HT4受體 - 维基百科，自由的百科全书
Aminorex. *Amphetamines (eg.、chlorphentermine、cloforex、dexfenfluramine、氟苯丙胺、levofenfluramine、norfenfluramine） ...
https://zh.wikipedia.org/wiki/5-HT4%E5%8F%97%E9%AB%94
Federal Register :: Controlled Substances: Proposed Aggregate Production Quotas for 2012Federal Register :: Controlled Substances: Proposed Aggregate Production Quotas for 2012
Aminorex. 2. Benzylmorphine. 2. Betacetylmethadol. 2. Beta-hydroxy-3-methylfentanyl. 2. Beta-hydroxyfentanyl. 2. ...
https://www.federalregister.gov/documents/2011/10/21/2011-27283/controlled-substances-proposed-aggregate-production-quotas-for-2012
Chapter 90 - Article 5Chapter 90 - Article 5
a. Aminorex. Some trade or other names: aminoxaphen; 2-amino-5-phenyl-2-oxazoline; or 4,5-dihydro-5-phenyl-2-oxazolamine. ...
https://www.ncleg.net/EnactedLegislation/Statutes/HTML/ByArticle/Chapter_90/Article_5.html
S119 [Edition 4]S119 [Edition 4]
a. Aminorex. Some trade or other names: aminoxaphen; 2‑amino‑5‑phenyl‑2‑oxazoline;. or 4,5‑dihydro‑5‑phenly‑2‑oxazolamine.. or ...
https://www.ncleg.net/Sessions/2015/Bills/Senate/HTML/S119v4.html
2018 - Lipomed2018 - Lipomed
Aminorex. 1585. I. 4-Methylaminorex (cis isomer). 1590. I. Gamma Hydroxybutyric Acid. 2010. I. ...
https://www.deadiversion.usdoj.gov/fed_regs/imprt/app/2018/fr1120_5.htm
5 banned or discontinued appetite suppressants | MNN - Mother Nature Network5 banned or discontinued appetite suppressants | MNN - Mother Nature Network
Aminorex: Dont remember the days when your weight-conscious pals were wild about Aminorex? Well, its probably because you ... The Aminorex fad was mercifully short-lived as usage of the drug resulted in an "epidemic of pulmonary hypertension" in those ...
https://www.mnn.com/health/fitness-well-being/stories/5-banned-or-discontinued-appetite-suppressants
2018 - Established Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for...2018 - Established Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for...
Aminorex. 25. Anileridine. 20. APINACA, AKB48 (N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide). 25. ...
https://www.deadiversion.usdoj.gov/fed_regs/quotas/2018/fr1228.htm
Pharmacovigilance in a rare disease: example of the VIGIAPATH program in pulmonary arterial hypertension | SpringerLinkPharmacovigilance in a rare disease: example of the VIGIAPATH program in pulmonary arterial hypertension | SpringerLink
Aminorex and pulmonary hypertension. A review. Cor Vasa. 1985;27:160-71.PubMedGoogle Scholar ...
https://link.springer.com/article/10.1007%2Fs11096-018-0712-y
Erowid Psychoactive VaultsErowid Psychoactive Vaults
Background Aminorex and methcathinone are stimulants that are controlled domestically in Schedule I of the CSA. Neither ... Aminorex 2. Brotizolam 3. Etryptamine (ALPHA-ethyltryptamine) 4. Flunitrazepam 5. Mesocarb (sydnocarb)* 6. Methcathinone ( ...
https://www.erowid.org/chemicals/chemicals_law1.shtml
Obesity Treatment & Management: Approach Considerations, Patient Screening, Assessment, and Expectations, Weight-Loss GoalsObesity Treatment & Management: Approach Considerations, Patient Screening, Assessment, and Expectations, Weight-Loss Goals
Obesity is a substantial public health crisis in the United States and in the rest of the industrialized world. The prevalence is increasing rapidly in numerous industrialized nations worldwide.
https://emedicine.medscape.com/article/123702-treatment
EnviroLink Forum • View topic - Animal testing: an evil jokeEnviroLink Forum • View topic - Animal testing: an evil joke
Aminorex pulmonary hypertension. Benoxaprofen fatalities, phototoxicity. Chloramphenicol aplastic anaemia. Clindamycin ... Aminorex pulmonary hypertension. Benoxaprofen fatalities, phototoxicity. Chloramphenicol aplastic anaemia. Clindamycin ...
http://www.envirolink.org/forum/viewtopic.php?p=192591
View the content page [c]View the content page [c]
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
http://www.let.rug.nl/~gosse/termpedia2/termpedia.php?language=dutch_general&density=7&link_color=000000&termpedia_system=perl_db&url=http%3A%2F%2Fen.wikipedia.org%2Fwiki%2FVortioxetine
Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriemNoteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem
Chapter 95 - MN LawsChapter 95 - MN Laws
any other substance, except bupropion or compounds listed under a different schedule, that is structurally derived from 2-aminopropan-1-one by substitution at the 1-position with either phenyl, naphthyl, or thiophene ring systems, whether or not the compound is further modified in any of the following ways:. (i) by substitution in the ring system to any extent with alkyl, alkylenedioxy, alkoxy, haloalkyl, hydroxyl, or halide substituents, whether or not further substituted in the ring system by one or more other univalent substituents;. (ii) by substitution at the 3-position with an acyclic alkyl substituent;. (iii) by substitution at the 2-amino nitrogen atom with alkyl, dialkyl, benzyl, or methoxybenzyl groups; or. (iv) by inclusion of the 2-amino nitrogen atom in a cyclic structure.. (h) Marijuana, tetrahydrocannabinols, and synthetic cannabinoids. Unless specifically excepted or unless listed in another schedule, any natural or synthetic material, compound, mixture, or preparation that ...
https://www.revisor.mn.gov/laws/2017/0/95/laws.2.15.0
Pulmonary HTN -Goya Flashcards by Brianna Thiessen | BrainscapePulmonary HTN -Goya Flashcards by Brianna Thiessen | Brainscape
Study Pulmonary HTN -Goya flashcards from Brianna Thiessen
https://www.brainscape.com/flashcards/pulmonary-htn-goya-3146765/packs/4926887
Popis opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za...Popis opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za...
Aminorex. 2-amino-5-fenil-2-oksazolin. 2-amino-5-phenyl-2-oxazoline ...
https://narodne-novine.nn.hr/clanci/sluzbeni/2009_04_50_1175.html
Popis opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za...Popis opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za...
Narodne novine d.d se obvezuju poštivati anonimnost i privatnost korisnika ovih internetskih stranica. O posjetiteljima se neće prikupljati nikakvi osobni podaci osim u slučajevima ako ih posjetitelj dobrovoljno dostavi Narodnim novinama d.d. U slučajevima kad je poznat indentitet posjetitelja/pošiljatelja, njegovi će se podaci koristiti samo u svrhu zbog koje ih je pošiljatelj poslao. Narodne novine d.d. takve podatke mogu koristiti i za što bolji uvid i razumijevanja pojedinačnih potreba i zahtjeva korisnika kao i razvijanja mogućnosti što kvalitetnijega pružanja svojih usluga korisnicima. Narodne novine d.d. se obvezuju da navedene podatke neće učiniti dostupnim bilo kojoj trećoj osobi odnosno strani bez izričitoga pristanka korisnika ...
https://narodne-novine.nn.hr/clanci/sluzbeni/2004_11_163_2865.html
Pulmonary Hypertension CausesPulmonary Hypertension Causes
This page includes the following topics and synonyms: Pulmonary Hypertension Causes, Causes of Pulmonary Hypertension, Pulmonary Arterial Hypertension Causes, Medication Causes of Pulmonary Arterial Hypertension, Drug-Induced Pulmonary Arterial Hypertension.
https://fpnotebook.com/legacy/CV/Lung/PlmnryHyprtnsnCs.htm
Fassung Anlage II BtMG a.F. bis 21.06.2017 (geändert durch Artikel 1 V. v. 16.06.2017 BGBl. I S. 1670)Fassung Anlage II BtMG a.F. bis 21.06.2017 (geändert durch Artikel 1 V. v. 16.06.2017 BGBl. I S. 1670)
Aminorex , - , 5-Phenyl-4,5-dihydro-1,3-oxazol-2-ylazan - , Benzylpiperazin (BZP) , 1-Benzylpiperazin Butalbital , - , 5-Allyl- ...
https://www.buzer.de/gesetz/631/al61623-0.htm
FenfluraminePulmonaryDerivative of aminorexAmphetamineCocaineToxicStimulantAttributed to the release of catecholaminesEpidemicFumarateAppetiteSerotoninDerivativesPemolineLevamisoleMetabolitesClosely related1990sPotentEffectsWikipediaListSafetyDrug
Fenfluramine8
  • Methods and Results Using the whole-cell, patch-clamp technique, we found that aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in smooth muscle cells taken from the small resistance pulmonary arteries of the rat lung. (ahajournals.org)
  • In the isolated, perfused rat lung, aminorex, fenfluramine, and dexfenfluramine induce a dose-related increase in perfusion pressure. (ahajournals.org)
  • The mechanism by which aminorex or fenfluramine might cause pulmonary hypertension is unknown but might resemble that responsible for hypoxic pulmonary vasoconstriction, in which K + channel inhibition leads to membrane depolarization and Ca 2+ entry through the voltage-dependent Ca 2+ channels. (ahajournals.org)
  • 14 We hypothesized that inhibition of an I K , which initiates hypoxic pulmonary vasoconstriction in pulmonary vascular smooth muscle, 13 15 might play a role in the pulmonary hypertension sometimes associated with aminorex and fenfluramine ingestion. (ahajournals.org)
  • [4] ] A second study in which rats trained to discriminate either 0.75 mg/kg S(+)-amphetamine or 1.5 mg/kg fenfluramine from saline generalized to aminorex as amphetamine stimulus but not to fenfluramine. (wikidoc.org)
  • Epidemiologically, the appetite suppressants that are clearly associated with PPH are mainly fenfluramine, dexfenfluramine, and aminorex, which caused an epidemic of PPH during the late sixties in central Europe 8 . (ersjournals.com)
  • Fenfluramine derivatives share with aminorex such characteristics as being potent serotonin (5-HT) uptake inhibitors and interacting directly with the 5-HT transporter 11 . (ersjournals.com)
  • The serotonin hypothesis of PAH originated in the 1960s after an outbreak of the disease was reported among patients taking the anorexigenic drugs aminorex and fenfluramine. (nih.gov)
Pulmonary10
  • Aminorex and pulmonary hypertension. (wikipedia.org)
  • Background The appetite suppressant aminorex fumarate is thought to have caused an epidemic of pulmonary hypertension in Europe in the 1960s. (ahajournals.org)
  • Adverse side effects of Aminorex are pulmonary hypertension, clonic seizures and a reduction in Tryptophan hydroxylase activity. (owndoc.com)
  • The Aminorex fad was mercifully short-lived as usage of the drug resulted in an " epidemic of pulmonary hypertension " in those three countries, with cases of the serious lung disorder increasing tenfold. (mnn.com)
  • Although this clearly indicated a role as a risk factor, the clinical course of aminorex-associated PAH was not conclusively different from idiopathic PAH (IPAH, formerly known as primary pulmonary hypertension), despite later results suggesting a better survival in the first group 7 . (ersjournals.com)
  • In fact, only ~2% of those who ingested aminorex during the period of the "epidemic" developed primary pulmonary hypertension [3]. (drugs-forum.com)
  • Aminorex pulmonary hypertension, In: Fishman AP, ed. (drugs-forum.com)
  • 4] Mielke H, Seiler KU, Stumpf U, Wasserman O. Influence of aminorex (menocil) on pulmonary pressure and on the content of biogenic amines in the lungs of rats. (drugs-forum.com)
  • In 1971 aminorex, or aminoxaphen, a new appetite suppressant, was taken off the market in Europe shortly after marketing because of an outbreak of pulmonary hypertension linked to this drug (13). (lowcarber.org)
  • 3. Karch SB, Defraia B, Messerini L, Mari F, Vaiano F, Bertol E. Aminorex associated with possible idiopathic pulmonary hypertension in a cocaine user. (radiopaedia.org)
Derivative of aminorex2
  • Pemoline, the 4-keto derivative of aminorex, had been discovered several years earlier, and derivatives of this type appeared to be effective stimulants with comparatively low toxicity. (wikipedia.org)
  • 4,4'-DMAR is a derivative of aminorex, has psychostimulant properties, and is reported to have been available on the drug market since at least December 2012. (europa.eu)
Amphetamine2
  • The synthesis was first reported in a structure-activity relationship study of 2-amino-5-aryl-2-oxazolines, where aminorex was found to be approximately 2.5 times more potent than D-amphetamine sulfate in inducing anorexia in rats, and was also reported to have CNS stimulant effects. (wikipedia.org)
  • This was associated with the use of the amphetamine-like, appetite-suppressant drug aminorex fumarate (2-amino-5-phenyl-2-oxazoline). (ahajournals.org)
Cocaine1
  • 2. Karch SB, Mari F, Bartolini V, Bertol E. Aminorex poisoning in cocaine abusers. (radiopaedia.org)
Toxic1
  • The requirement for highly toxic precursors such as cyanogen bromide making the synthesis of aminorex and its derivatives potentially very dangerous for inexperienced clandestine chemists, has now been superseded with a newer route using cyanate salts which is easier, safer & cleaner. (chemeurope.com)
Stimulant4
  • Aminorex has been shown to have locomotor stimulant effects, lying midway between dextroamphetamine and methamphetamine. (wikipedia.org)
  • Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. (wikipedia.org)
  • The effects of Aminorex are stimulant in nature, producing an increase in attention, auphoria and increased cognition. (owndoc.com)
  • Aminorex is an anorectic stimulant drug of the 2- Amino -5-Aryloxazoline class. (chemeurope.com)
Attributed to the release of catecholamines1
  • Aminorex effects have been attributed to the release of catecholamines. (wikipedia.org)
Epidemic2
  • The fact that the epidemic started 2 yrs after aminorex fumarate became commercially available and disappeared 2 yrs after the drug was withdrawn, allowed the recognition of temporal and geographic relationships between the use of the drug and PAH development 6 . (ersjournals.com)
  • The general hysteria involved in the "aminorex epidemic", which resulted in its removal from the world market, may have been an overreaction. (drugs-forum.com)
Fumarate1
  • 60% had a history of intake of the anorexigen aminorex fumarate 5 . (ersjournals.com)
Appetite1
  • Aminorex reduces appetite and may keep a person awake for up to 36 hours. (owndoc.com)
Serotonin3
  • High chronic dosages of Aminorex may cause increase in Serotonin levels. (owndoc.com)
  • Now, primary pulmatory hypertension attributed to aminorex is believed to be linked to the release of catecholamines and norepinephrine, while "fen/phen" owes its toxicity to the unfortunate combination of the two drugs methods of inhibiting the removal of serotonin from the blood and causing the release of a large amount of serotonin into the blood. (drugs-forum.com)
  • I'm not sure if this is appropriate (on-topic) place for this post, but I just wanted to let people know that 4-Methyl Aminorex (U-4EA) is implicated in causing the same type of cardiac valvular damage that phen-fen caused in patients due to serotonin-release in the vasculature. (drugs-forum.com)
Derivatives1
  • Ring-substituted aminorex derivatives have yet to be researched, but seem likely candidates for a new generation of designer drugs since the immediate precursors are legal and can easily be made from substituted benzaldehydes . (chemeurope.com)
Pemoline1
  • Fluminorex is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline . (gutenberg.org)
Levamisole3
  • Plasma and Urine Levamisole in Clinical Samples Containing Benzoylecgonine: Absence of Aminorex. (nih.gov)
  • Racing Analytical Services Limited (RASL) reported that the analysis of the urine sample revealed it to contain the prohibited substances levamisole and aminorex. (harnesslink.com)
  • It is alleged that Mr Aiken presented 'The Defiant' to race at the Shepparton trial meeting on 29 August 2017 when not free of the prohibited substances Levamisole and Aminorex. (harnesslink.com)
Metabolites1
  • PMID 7667356 Zheng Y, Russell B, Schmierer D, Laverty R. The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice. (wikipedia.org)
Closely related1
  • It is closely related to the popular drug 4-methyl-aminorex . (chemeurope.com)
1990s1
  • The drug reappeared as a designer analog of 4-methyl-aminorex in the US during the 1990s. (chemeurope.com)
Potent1
  • It is, in fact, 4 times stronger than 4-methyl-aminorex and the 4-fluoro analog is listed as four times as potent again as an anorectic (in rats), but is unknown outside the laboratory. (chemeurope.com)
Effects2
  • One of Aminorex side effects is a strong physical and psychological dependency. (owndoc.com)
  • This is our research on the alleged dangers of Aminorex / adverse effects of Aminorex and not medical advice! (owndoc.com)
Wikipedia1
  • It uses material from the Wikipedia article "Aminorex" . (chemeurope.com)
List1
Safety1
  • The debate over the "safety" of the aminorex analogs has long been in dispute, and I feel that it is important to address this controversial subject, as it may be of concern to many of us. (drugs-forum.com)
Drug1
  • Tous les résultats de la recherche seront tirés du « National Drug Schedules » du site Web en anglais. (napra.ca)