Aminorex: An amphetamine-like anorectic agent. It may cause pulmonary hypertension.Phenmetrazine: A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.Appetite Depressants: Agents that are used to suppress appetite.Dexfenfluramine: The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess any catecholamine agonist activity.Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.Pulmonary Artery: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.Pausinystalia: A plant genus of the family RUBIACEAE. Members produce YOHIMBINE.Yohimbine: A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.Veterinary Drugs: Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.Drug and Narcotic Control: Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.United States Department of Agriculture: A cabinet department in the Executive Branch of the United States Government concerned with improving and maintaining farm income and developing and expanding markets for agricultural products. Through inspection and grading services it safeguards and insures standards of quality in food supply and production.North CarolinaResearch Subjects: Persons who are enrolled in research studies or who are otherwise the subjects of research.Legislation, Drug: Laws concerned with manufacturing, dispensing, and marketing of drugs.Methyltestosterone: A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL).United States Department of Homeland Security: A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to domestic national security.Diethylpropion: A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)Phentermine: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.Appetite: Natural recurring desire for food. Alterations may be induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.Students, Health Occupations: Individuals enrolled in a school or formal educational program in the health occupations.Dental Technicians: Individuals responsible for fabrication of dental appliances.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.United States National Aeronautics and Space Administration: An independent Federal agency established in 1958. It conducts research for the solution of problems of flight within and outside the Earth's atmosphere and develops, constructs, tests, and operates aeronautical and space vehicles. (From U.S. Government Manual, 1993)Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Support Vector Machines: Learning algorithms which are a set of related supervised computer learning methods that analyze data and recognize patterns, and used for classification and regression analysis.Artificial Intelligence: Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.Animal Technicians: Assistants to a veterinarian, biological or biomedical researcher, or other scientist who are engaged in the care and management of animals, and who are trained in basic principles of animal life processes and routine laboratory and animal health care procedures. (Facts on File Dictionary of Health Care Management, 1988)Existentialism: Philosophy based on the analysis of the individual's existence in the world which holds that human existence cannot be completely described in scientific terms. Existentialism also stresses the freedom and responsibility of the individual as well as the uniqueness of religious and ethical experiences and the analysis of subjective phenomena such as anxiety, guilt, and suffering. (APA, Thesaurus of Psychological Index Terms, 8th ed.)Educational Measurement: The assessing of academic or educational achievement. It includes all aspects of testing and test construction.Philosophy: A love or pursuit of wisdom. A search for the underlying causes and principles of reality. (Webster, 3d ed)Philosophy, MedicalDissertations, Academic as Topic: Dissertations embodying results of original research and especially substantiating a specific view, e.g., substantial papers written by candidates for an academic degree under the individual direction of a professor or papers written by undergraduates desirous of achieving honors or distinction.Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.Interior Design and Furnishings: The planning of the furnishings and decorations of an architectural interior.Indonesia: A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith.Malaysia: A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)AustriaMedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Yin-Yang: In Chinese philosophy and religion, two principles, one negative, dark, and feminine (yin) and one positive, bright, and masculine (yang), from whose interaction all things are produced and all things are dissolved. As a concept the two polar elements referred originally to the shady and sunny sides of a valley or a hill but it developed into the relationship of any contrasting pair: those specified above (female-male, etc.) as well as cold-hot, wet-dry, weak-strong, etc. It is not a distinct system of thought by itself but permeates Chinese life and thought. A balance of yin and yang is essential to health. A deficiency of either principle can manifest as disease. (Encyclopedia Americana)YY1 Transcription Factor: A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.Cholesterol Ester Transfer Proteins: Proteins that bind to and transfer CHOLESTEROL ESTERS between LIPOPROTEINS such as LOW-DENSITY LIPOPROTEINS and HIGH-DENSITY LIPOPROTEINS.Spiro Compounds: A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.QuinolinesPatents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.Anticholesteremic Agents: Substances used to lower plasma CHOLESTEROL levels.Sulfhydryl Compounds: Compounds containing the -SH radical.

Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. (1/4)

BACKGROUND: Coadministration of phentermine and fenfluramine (phen/fen) effectively treats obesity and possibly addictive disorders. The association of fenfluramine and certain other anorexic agents with serious side effects, such as cardiac valvulopathy and primary pulmonary hypertension (PPH), limits the clinical utility of these drugs. Development of new medications that produce neurochemical effects like phen/fen without causing unwanted side effects would be a significant therapeutic breakthrough. METHODS AND RESULTS: We tested the hypothesis that fenfluramine (and other anorexic agents) might increase the risk of PPH through interactions with serotonin (5-HT) transporters. Because 5-HT transporter proteins in the lung and brain are identical, we examined, in rat brain, the effects of selected drugs on 5-HT efflux in vivo and monoamine transporters in vitro as a generalized index of transporter function. Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard. CONCLUSIONS: We speculate that medications that are 5-HT transporter substrates get translocated into pulmonary cells where, depending on the degree of drug retention, their intrinsic drug toxicity, and individual susceptibility, PPH could develop as a response to high levels of these drugs or metabolites. Emerging evidence suggests that it is possible to develop transporter substrates devoid of adverse side effects. Such medications could have therapeutic application in the management of obesity, drug dependence, depression, and other disorders.  (+info)

Delayed onset of pulmonary hypertension associated with an appetite suppressant, mazindol: a case report. (2/4)

The use of the appetite suppressant agents aminorex and fenfluramine derivatives has been reported as a risk factor for the development of pulmonary hypertension. A 29-year-old female developed pulmonary hypertension suspected to be due to an amphetamine-like appetite suppressant agent, mazindol ((+/-)-5-(p-chlorophenyl)-2,5-dihydro-3H-imidazo [2,1-a] isoindol-5-ol). She was admitted to Sapporo Medical University Hospital with dyspnea due to severe pulmonary hypertension. Twelve months prior to admission, she had taken mazindol continuously for a period of 10 weeks. As yet, her pulmonary hypertension has not completely improved. This is the first reported case of mazindol-associated pulmonary hypertension, which developed after a long latent interval, and it suggests that mazindol is also a risk factor for the development of pulmonary hypertension, making long-term follow-up necessary for patients taking this anorectic agent.  (+info)

Drug-induced pulmonary hypertension? (3/4)

Of 40 patients with obstructive pulmonary hypertension studied in Basle, Switzerland, during the period 1966-68, 32 had been taking an anorectic drug, aminorex fumarate. Rapidly progressing exertional dyspnoea, central chest pain, and syncope on effort were characteristic features. The absence of the usual causes of pulmonary vascular disease seems to suggest the possibility of drug-induced pulmonary hypertension. Further studies are necessary, however, to clarify the role of aminorex fumarate in this condition.  (+info)

Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. (4/4)

BACKGROUND: The appetite suppressant aminorex fumarate is thought to have caused an epidemic of pulmonary hypertension in Europe in the 1960s. More recently, pulmonary hypertension has been described in some patients taking other amphetamine-like, anorexic agents: fenfluramine and its d-isomer, dexfenfluramine. No mechanism has been demonstrated that might account for the association between anorexic drugs and pulmonary hypertension. METHODS AND RESULTS: Using the whole-cell, patch-clamp technique, we found that aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in smooth muscle cells taken from the small resistance pulmonary arteries of the rat lung. Dexfenfluramine causes reversible membrane depolarization in these cells. These actions are similar to those of hypoxia, which initiates pulmonary vasoconstriction by inhibiting a potassium current in pulmonary vascular smooth muscle. In the isolated, perfused rat lung, aminorex, fenfluramine, and dexfenfluramine induce a dose-related increase in perfusion pressure. When the production of endogenous NO is inhibited by N-nitro-L-arginine methyl ester, the pressor response to dexfenfluramine is greatly enhanced. CONCLUSIONS: These observations indicate that anorexic agents, like hypoxia, can inhibit potassium current, cause membrane depolarization, and stimulate pulmonary vasoconstriction. They suggest one mechanism that could be responsible for initiating pulmonary hypertension in susceptible individuals. It is possible that susceptibility is the result of the reduced production of an endogenous vasodilator, such as NO, but this remains speculative.  (+info)

Aminorex is thought to have been responsible for the epidemic of pulmonary hypertension that occurred in Europe in the late 1960s.1 2 Only 1% to 2% of those who ingested the drug developed significant pulmonary hypertension.2 This limited susceptibility to the drug is similar to that noted after exposure to toxic oil, when only ≈1.5% of those exposed to contaminated rapeseed oil had pulmonary hypertension on follow-up 4 years later.19 It is not known whether those who develop pulmonary hypertension metabolize aminorex more slowly and consequently have higher tissue levels or whether their pulmonary arteries are more susceptible in some way, such as a lower endogenous production of NO. In more recent years, the anorexic agents fenfluramine and dexfenfluramine have been widely used for weight reduction12 20 and have also been associated with sporadic cases of pulmonary hypertension.3 4 5 6 7 8 9 10 11 Despite many studies, the mechanism by which these drugs might initiate pulmonary hypertension ...
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Prospectively predicting PK of hepatic transporter substrates in clinical studies remains a challenging task, particularly in predicting liver exposures. Although several approaches have been developed to face this challenge, most focus only on systemic exposure. In addition, due to the use of compound-dependent empirical scaling factors estimated by fitting clinical observation, these published works are more retrospective analyses but are rarely tested prospectively. Similarly, when predicting liver exposure-driven DDI and toxicity of transporter substrates, most published approaches allow floating parameters to match clinical observations. Hence, confidence in using these approaches in real-world drug discovery and development is low.. There are two obstacles impeding progress: 1) comprehensive knowledge of human transporter activity and 2) human liver exposure data to valid prediction approaches developed. The former problem is a result of the latter. Without direct measurement of the liver, ...
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A molecular model of cocaine (C17H21NO4), a stimulant and appetite suppressant drug, obtained from coca plant leaves, which produces low doses of anaesthesia. Cocaines properties allow it to pass through the blood-brain barrier more easily than other psychoactive chemicals. The drugs addictive nature makes more dangerous than other stimulants, as higher doses can lead to sudden cardiac death. Atoms are coloured dark gray (carbon), light gray (hydrogen), red (oxygen), and blue (nitrogen). - Stock Image C028/0451
Benzphetamine is a stimulant that is similar to an amphetamine. Benzphetamine is an appetite suppressant that affects the central nervous system. Benzphetamine is used together with diet and exercise to treat obesity (overweight). Benzphetamine may also be used for purposes not listed in this medication guide.
Water is actually considered a nutrient, which means it is just as important as vitamins, minerals and macronutrients like proteins and fats. All of the biochemical reactions in your body occur in a suspension of...you guessed it. water.. Lucky for those trying to lose weight, water acts as a natural appetite suppressant, filling our bellies and bloodstreams with more free-flowing hydration. With a stomach filled with water, we are less likely to eat as much, and what we do eat is normally better digested, because hydration is imperative for proper digestion. The elimination process is facilitated by water as well, decreasing the likelihood of developing constipation by keeping your digestive tract moist and lubricated.. Drinking water also helps weight loss by breaking down fat tissue down and moving it into the liver. While increasing water intake can reduce fat deposits, if your hydration halts, fat deposits are more likely to form.. Dont kid around with your kidneys, they need lots of water ...
Aminorex • Clominorex • Cyclazodone • Fenozolone • Fluminorex • Pemoline • Thozalinone Phenethylamines (also amphetamines, ...
AMINOREX 2. ANFEPRAMONE (DIETILPROPIONA) 3. FEMPROPOREX 4. FENDIMETRAZINE 5. FENTERMIN 6. MAZINDOL 7. MEFENOREX 1. ACEPROMAZINE ...
This was the case with aminorex in the 1960s, and again in the 1990s with fenfluramine (see: Fen-phen). Likewise, association ... Fishman, A. P. (1999). "Aminorex to Fen/Phen : An Epidemic Foretold". Circulation. 99 (1): 156-61. doi:10.1161/01.cir.99.1.156 ...
In the Netherlands, aminorex (4-methylaminorex is a designer drug 2014) is a List I drug of the Opium Law. It is not approved ... Zheng Y, Russell B, Schmierer D, Laverty R (January 1997). "The effects of aminorex and related compounds on brain monoamines ... Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA (November 2000). "Recreational use of aminorex and pulmonary hypertension ... 1985), the results suggest that the aminorex compounds except 4S,5S-dimethylaminorex, unlike MDMA or fenfluramine, are not ...
Alfred P. Fishman, MD (1999). "Aminorex to Fen/Phen: An Epidemic Foretold". Circulation. 99 (1): 156-161. doi:10.1161/01.CIR. ...
Aminorex Cericlamine Cloforex Clortermine Etolorex Fenfluramine Methylenedioxyphentermine Phentermine Gylys, JA; Hart, JJ; ... Rothman, RB; Ayestas, MA; Dersch, CM; Baumann, MH (Aug 1999). "Aminorex, fenfluramine, and chlorphentermine are serotonin ... as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex ...
... meaning that both humans and dogs also metabolize levamisole into aminorex. The stimulant properties of aminorex contribute to ... 2009) "Aminorex and pemoline as metabolites of levamisole in the horse." Anal Chem Acta. 638(1); 58-68. J. Scarth et al. (2010 ... pp 213-222 Bertol E, Mari F, Milia MG, Politi L, Furlanetto S, Karch SB (2011). "[Determination of aminorex in human urine ... Further testing confirmed aminorex in human and canine urine, ... levamisole equine metabolites are both pemoline and aminorex, ...
... is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline. It was ... 4-Methylaminorex Aminorex Cyclazodone Fenozolone Fluminorex Pemoline Thozalinone US Patent 3278382 - 2-amino-5-aryloxazoline ...
A similar drug, aminorex, had caused severe lung damage and "provided reason to worry that similar drugs ... could increase the ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Aminorex, in the 2-amino-5-aryl oxazoline class, was developed by McNeil Laboratories in 1962. It is closely related to 4- ... Aminorex effects have been attributed to the release of catecholamines. It was discovered in 1962 by Edward John Hurlburt, and ... Jan 1991). "Aminorex to fen/phen - An epidemic foretold". Circulation. 99 (1): 156-161. doi:10.1161/01.CIR.99.1.156. ISSN 0009- ... Aminorex (Menocil, Apiquel, aminoxaphen, aminoxafen, McN-742) is a weight loss (anorectic) stimulant drug. It was withdrawn ...
Question 7: Aminorex has been shown to have locomotor stimulant effects, lying midway between ________ and methamphetamine.. ... Question 8: ________ • Aminorex • Clominorex • Cyclazodone • Fenozolone • Fluminorex • Pemoline • Thozalinone. Cocaine. MDMA. 4 ... Question 3: ________ • Aminorex • Clominorex • Cyclazodone • Fenozolone • Fluminorex • Pemoline • Thozalinone. Benzylpiperazine ...
Aminorex and fenfluramine inhibit whole-cell IK. A, Aminorex (10 mmol/L) and 4-AP (2 mmol/L) inhibit whole-cell IK in five rat ... Chronic administration of aminorex to small numbers of monkeys,27 calves,28 and rats29 has not been found to cause pulmonary ... In dogs, three chronic studies failed to show pulmonary hypertension,29 30 31 but another study, in which aminorex was fed for ... In the aminorex (n=5) and fenfluramine (n=5) dose-response experiments, whole-cell IK were elicited by 20-mV step ...
... Aminorex used to be marketed as an anorexic agent. It acts as a stimulant. One of Aminorex side effects ... Aminorex side effects Aminorex used to be marketed as an anorexic agent. It acts as a stimulant. One of Aminorex side effects ... This is our research on the alleged dangers of Aminorex / adverse effects of Aminorex and not medical advice! ... High chronic dosages of Aminorex may cause increase in Serotonin levels. Aminorex reduces appetite and may keep a person awake ...
... Systematic (IUPAC) name 5-phenyl-4,5-dihydro-1,3-oxazol-2-amine Identifiers CAS number 2207-50-3 ATC code ? ... Aminorex is an anorectic stimulant drug of the 2-Amino-5-Aryloxazoline class. It is closely related to the popular drug 4- ... It is, in fact, 4 times stronger than 4-methyl-aminorex and the 4-fluoro analog is listed as four times as potent again as an ... Ring-substituted aminorex derivatives have yet to be researched, but seem likely candidates for a new generation of designer ...
4-Methyl-aminorex is a stimulant drug of the 2-Amino-5-Aryloxazoline class. Commonly called "Euphoria," "U4EA,", "U4Euh", " ... The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice. Zheng Y, Russell B, Schmierer D ... Recreational use of aminorex and pulmonary hypertension. Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA. Chest. 2000 Nov ... 3. Aminorex produces stimulus effects similar to amphetamine and unlike those of fenfluramine. Young R. Pharmacol Biochem Behav ...
Aminorex • Clominorex • Cyclazodone • Fenozolone • Fluminorex • Pemoline • Thozalinone Phenethylamines (also amphetamines, ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
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Aminorex. *Amphetamines (eg.、chlorphentermine、cloforex、dexfenfluramine、氟苯丙胺、levofenfluramine、norfenfluramine) ...
Aminorex. 2. Benzylmorphine. 2. Betacetylmethadol. 2. Beta-hydroxy-3-methylfentanyl. 2. Beta-hydroxyfentanyl. 2. ...
a. Aminorex. Some trade or other names: aminoxaphen; 2-amino-5-phenyl-2-oxazoline; or 4,5-dihydro-5-phenyl-2-oxazolamine. ...
Aminorex. 1585. I. 4-Methylaminorex (cis isomer). 1590. I. Gamma Hydroxybutyric Acid. 2010. I. ...
Aminorex. 25. APINCA, AKB48 (N-(1-adamantyl)-1-pentyl-1 H-indazole-3-carboxamide). 25. ...
Aminorex: Dont remember the days when your weight-conscious pals were wild about Aminorex? Well, its probably because you ... The Aminorex fad was mercifully short-lived as usage of the drug resulted in an "epidemic of pulmonary hypertension" in those ...
Aminorex. 25. Anileridine. 20. APINACA, AKB48 (N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide). 25. ...
Aminorex and pulmonary hypertension. A review. Cor Vasa. 1985;27:160-71.PubMedGoogle Scholar ...
Background Aminorex and methcathinone are stimulants that are controlled domestically in Schedule I of the CSA. Neither ... Aminorex 2. Brotizolam 3. Etryptamine (ALPHA-ethyltryptamine) 4. Flunitrazepam 5. Mesocarb (sydnocarb)* 6. Methcathinone ( ...
Obesity is a substantial public health crisis in the United States and in the rest of the industrialized world. The prevalence is increasing rapidly in numerous industrialized nations worldwide.
Aminorex pulmonary hypertension. Benoxaprofen fatalities, phototoxicity. Chloramphenicol aplastic anaemia. Clindamycin ... Aminorex pulmonary hypertension. Benoxaprofen fatalities, phototoxicity. Chloramphenicol aplastic anaemia. Clindamycin ...
Aminorex. *Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). * ...
Study Pulmonary HTN -Goya flashcards from Brianna Thiessen
Narodne novine d.d se obvezuju poštivati anonimnost i privatnost korisnika ovih internetskih stranica. O posjetiteljima se neće prikupljati nikakvi osobni podaci osim u slučajevima ako ih posjetitelj dobrovoljno dostavi Narodnim novinama d.d. U slučajevima kad je poznat indentitet posjetitelja/pošiljatelja, njegovi će se podaci koristiti samo u svrhu zbog koje ih je pošiljatelj poslao. Narodne novine d.d. takve podatke mogu koristiti i za što bolji uvid i razumijevanja pojedinačnih potreba i zahtjeva korisnika kao i razvijanja mogućnosti što kvalitetnijega pružanja svojih usluga korisnicima. Narodne novine d.d. se obvezuju da navedene podatke neće učiniti dostupnim bilo kojoj trećoj osobi odnosno strani bez izričitoga pristanka korisnika ...
Aminorex , - , 5-Phenyl-4,5-dihydro-1,3-oxazol-2-ylazan - , Benzylpiperazin (BZP) , 1-Benzylpiperazin Butalbital , - , 5-Allyl- ...
  • The requirement for highly toxic precursors such as cyanogen bromide making the synthesis of aminorex and its derivatives potentially very dangerous for inexperienced clandestine chemists, has now been superseded with a newer route using cyanate salts which is easier, safer & cleaner. (chemeurope.com)
  • Selumetinib molecular weight The metabolite aminorex itself modulates NET, DAT and SERT and results in a strong inhibition of NET and DAT substrate uptake and in substrate efflux at SERT. (sykpathway.com)
  • High chronic dosages of Aminorex may cause increase in Serotonin levels. (owndoc.com)
  • Now, primary pulmatory hypertension attributed to aminorex is believed to be linked to the release of catecholamines and norepinephrine, while "fen/phen" owes its toxicity to the unfortunate combination of the two drugs methods of inhibiting the removal of serotonin from the blood and causing the release of a large amount of serotonin into the blood. (drugs-forum.com)
  • I'm not sure if this is appropriate (on-topic) place for this post, but I just wanted to let people know that 4-Methyl Aminorex (U-4EA) is implicated in causing the same type of cardiac valvular damage that phen-fen caused in patients due to serotonin-release in the vasculature. (drugs-forum.com)
  • The drug reappeared as a designer analog of 4-methyl-aminorex in the US during the 1990s. (chemeurope.com)
  • It is, in fact, 4 times stronger than 4-methyl-aminorex and the 4-fluoro analog is listed as four times as potent again as an anorectic (in rats), but is unknown outside the laboratory. (chemeurope.com)
  • The debate over the "safety" of the aminorex analogs has long been in dispute, and I feel that it is important to address this controversial subject, as it may be of concern to many of us. (drugs-forum.com)
  • Tous les résultats de la recherche seront tirés du « National Drug Schedules » du site Web en anglais. (napra.ca)
  • 4,4'-DMAR is a derivative of aminorex, has psychostimulant properties, and is reported to have been available on the drug market since at least December 2012. (europa.eu)
  • Ring-substituted aminorex derivatives have yet to be researched, but seem likely candidates for a new generation of designer drugs since the immediate precursors are legal and can easily be made from substituted benzaldehydes . (chemeurope.com)