Aminopyrine. Medical search

A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.

A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.

Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.

Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.

Hydrochloric acid present in GASTRIC JUICE.

An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)

A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.

An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.

A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

A barbiturate that is effective as a hypnotic and sedative.

A group of compounds that contain a bivalent O-O group, i.e., the oxygen atoms are univalent. They can either be inorganic or organic in nature. Such compounds release atomic (nascent) oxygen readily. Thus they are strong oxidizing agents and fire hazards when in contact with combustible materials, especially under high-temperature conditions. The chief industrial uses of peroxides are as oxidizing agents, bleaching agents, and initiators of polymerization. (From Hawley's Condensed Chemical Dictionary, 11th ed)

Compounds with a five-membered heterocyclic ring with two nitrogens and a keto OXYGEN. Some are inhibitors of TNF-ALPHA production.

A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity.

A hypnotic and sedative. Its use has been largely superseded by other drugs.

A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.

The removing of alkyl groups from a compound. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol.

Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.

A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.

Any tests done on exhaled air.

An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.

A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)

Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.

Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.

A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.

A publication issued at stated, more or less regular, intervals.

Individuals licensed to practice medicine.

"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

Painful menstruation.

Any technique by which an unknown color is evaluated in terms of standard colors. The technique may be visual, photoelectric, or indirect by means of spectrophotometry. It is used in chemistry and physics. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)

A country spanning from central Asia to the Pacific Ocean.

The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.

An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.

A metabolite of AMINOPYRINE with analgesic and anti-inflammatory properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates LIVER MICROSOMES and is also used to measure extracellular water.

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Receptors of CLONIDINE and other IMIDAZOLINES. Activity of the ligands was earlier attributed to ADRENERGIC ALPHA-2 RECEPTORS. Endogenous ligands include AGMATINE, imidazoleacetic acid ribotide, and harman.

The superior portion of the body of the stomach above the level of the cardiac notch.

Compounds based on reduced IMIDAZOLES containing a single double bond.

A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.

Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.

Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)

A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat. (1/181)

Despite its hepatotoxic potential, cyclosporine A (CsA) has been reported to positively influence compensatory liver growth. To probe the physiological consequences of CsA on the recovery of liver function, studies were initiated in the 2/3 partially hepatectomized (PHx) rat, taking the recovery of cytochromes P-450-dependent drug metabolism as primary outcome. CsA was administered at a dose of 3. 33 mg/kg/day for 10 days. Drug metabolism was evaluated by the recovery of 14CO2 after administration of isotopically labeled model drugs and by studying the expression of the P-450 transcripts involved in their biotransformation before and 24 to 96 h after PHx. Before PHx, neither the steady-state mRNA nor the in vivo disposition of caffeine (CYP1A2), erythromycin (CYP3A2 and 3A1), or aminopyrine (CYP2B1 and 2C11) were influenced by CsA. Studies 24 h after PHx revealed a 29 to 39% reduction in the elimination of [14C]aminopyrine and [14C]erythromycin, which was unaffected by CsA. Their metabolism at 48 to 96 h after PHx also remained unaffected by CsA. By contrast, postPHx, [14C]caffeine elimination decreased to a level closely proportional to the loss in liver mass. In addition, CsA accelerated the recovery and/or prevented the decrease of caffeine elimination 24 h after PHx but not at later time points, indicating an early, but unsustained, beneficial effect of CsA on the recovery of CYP1A2-mediated activities. These data show that at the critical time of greatest loss in liver mass, CsA has only a selective influence on the biotransformation of cytochrome P-450 protein-dependent activities and that its effect on the regeneration process does not translate into an overall accelerated recovery of the hepatic drug-metabolizing function. (+info)

L-365,260 inhibits in vitro acid secretion by interacting with a PKA pathway. (2/181)

The aim of this study was to analyse the antisecretory mechanism of L-365,260 in vitro in isolated rabbit gastric glands. We showed that compound L-365,260, described as a non-peptide specific competitive CCK-B receptor antagonist, was able to dose-dependently inhibit [14C]-aminopyrine accumulation induced by histamine (10(-4) M), carbachol (5x10(-5) M), 3-isobutyl-1-methyl-xanthine (IBMX) (5x10(-6) M) and forskolin (5x10(-7) M) with similar IC50 values respectively of 1.1+/-0.6x10(-7) M, 1.9+/-1.2x10(-7) M, 4.2+/-2.0x10(-7) M and 4.0+/-2.8x10(-7) M. We showed that L-365,260 acted beyond receptor activation and production of intracellular second messengers and that it had no action on the H+/K+ -ATPase. We found that L-365,260 inhibited cyclic AMP-induced [14C]-aminopyrine accumulation in digitonin-permeabilized rabbit gastric glands, suggesting that this compound acted, at least in part, as an inhibitor of the cyclic AMP-dependent protein kinase (PKA) pathway. (+info)

Demethylation capacity of human fetal adrenal mitochondrial cytochrome P-450 in vitro. (3/181)

AIM: To explore the capacity and characteristics of adrenal mitochondria to metabolize xenobiotics in vitro in human fetus. METHODS: Subcellular fractions of fetal adrenal were prepared by differential centrifugation. Mitochondrial P-450 system was proved by spectral analyses and SDS-PAGE. The formaldehyde formation contents were measured with Nash reagent. RESULTS: The erythromycin N-demethylation linearly increased in the protein concentration (1-4 mg)- and incubation time (10-30 min)-dependent manners. A typical concentration-effect relationship appeared with erythromycin 0.067-1 mmol.L-1 and a positive correlation (r = 0.641, P < 0.05) existed between erythromycin N-demethylation and gestation months. The N-demethylation values (nmol.s-1/g protein) of erythromycin (2.7 +/- 0.8), benzfetamine (1.1 +/- 0.5), and aminophenazone (0.9 +/- 0.4) in mitochondria were 89% (P > 0.05), 162% (P < 0.01), and 62% (P < 0.01), respectively, of those in microsomes. There was correlation between mitochondria and microsomes in the N-demethylation of erythromycin (r = 0.708, P < 0.05) and benzfetamine (r = 0.707, P < 0.05). Troleandomycin stimulated erythromycin N-demethylation in adrenal mitochondria as well as in adrenal and liver microsomes in vitro. CONCLUSION: Fetal adrenal mitochondria, with multiple P-450 isoforms and greater capacity of demethylation, play a role in drug-metabolism during fetal development. (+info)

Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. (4/181)

Stimulation of the gastric parietal cell results in a massive redistribution of H+-K+-ATPase from cytoplasmic tubulovesicles to the apical plasma membrane. Previous studies have implicated the small GTPase rab11 in this process. Using matrix-assisted laser desorption mass spectrometry, we confirmed that rab11 is associated with H+-K+-ATPase-enriched gastric microsomes. A stoichiometry of one rab11 per six copies of H+-K+-ATPase was estimated. Furthermore, rab11 exists in at least three forms on rabbit gastric microsomes: the two most prominent resemble rab11a, whereas the third resembles rab11b. Using an adenoviral expression system, we expressed the dominant negative mutant rab11a N124I in primary cultures of rabbit parietal cells under the control of the tetracycline transactivator protein (tTA). The mutant was well expressed with a distribution similar to that of the H+-K+-ATPase. Stimulation of these cultures with histamine and IBMX was assessed by measuring the aminopyrine (AP) uptake relative to resting cells (AP index). In experiments on six culture preparations, stimulated uninfected cells gave an AP index of 10.0 +/- 2.9, whereas parallel cultures expressing rab11a N124I were poorly responsive to stimulation, with a mean AP index of 3.2 +/- 0. 9. Control cultures expressing tTA alone or tTA plus actin responded equally well to stimulation, giving AP index values of 9.0 +/- 3.1 and 9.6 +/- 0.9, respectively. Thus inhibition by rab11a N124I is not simply due to adenoviral infection. The AP uptake data were confirmed by immunocytochemistry. In uninfected cells, H+-K+-ATPase demonstrated a broad cytoplasmic distribution, but it was cleared from the cytoplasm and associated with apically derived membranes on stimulation. In cells expressing rab11a N124I, H+-K+-ATPase maintained its resting localization on stimulation. Furthermore, this effect could be alleviated by culturing infected cells in the presence of tetracycline, which prevents expression of the mutant rab11. We therefore conclude that rab11a is the prominent GTPase associated with gastric microsomes and that it plays a role in parietal cell activation. (+info)

Responsiveness of beta-escin-permeabilized rabbit gastric gland model: effects of functional peptide fragments. (5/181)

We established a beta-escin-permeabilized gland model with the use of rabbit isolated gastric glands. The glands retained an ability to secrete acid, monitored by [14C]aminopyrine accumulation, in response to cAMP, forskolin, and histamine. These responses were all inhibited by cAMP-dependent protein kinase inhibitory peptide. Myosin light-chain kinase inhibitory peptide also suppressed aminopyrine accumulation, whereas the inhibitory peptide of protein kinase C or that of calmodulin kinase II was without effect. Guanosine-5'-O-(3-thiotriphosphate) (GTPgammaS) abolished cAMP-stimulated acid secretion concomitantly, interfering with the redistribution of H+-K+-ATPase from tubulovesicles to the apical membrane. To identify the targets of GTPgammaS, effects of peptide fragments of certain GTP-binding proteins were examined. Although none of the peptides related to Rab proteins showed any effect, the inhibitory peptide of Arf protein inhibited cAMP-stimulated secretion. These results demonstrate that our new model, the beta-escin-permeabilized gland, allows the introduction of relatively large molecules, e.g., peptides, into the cell, and will be quite useful for analyzing signal transduction of parietal cell function. (+info)

Regulation and function of p38 protein kinase in isolated canine gastric parietal cells. (6/181)

We examined the regulation and functional role of p38 kinase in gastric acid secretion. p38 kinase was immunoprecipitated from cell lysates of highly purified gastric parietal cells in primary culture, and its activity was quantitated by in vitro kinase assay. Carbachol effects were dose- and time-dependent, with a maximal 10-fold stimulatory effect detected after 30 min of incubation. SB-203580, a highly selective inhibitor of p38 kinase, blocked carbachol induction of p38 kinase activity, with maximal inhibition at 10 microM. Stimulation by carbachol was unaffected by preincubation of parietal cells with the intracellular Ca(2+) chelator BAPTA-AM, but incubation of cells in Ca(2+)-free medium led to a 50% inhibition of carbachol induction of p38 kinase activity. Because some of the effects of carbachol are mediated by the small GTP-binding protein Rho, we examined the role of Rho in carbachol induction of p38 kinase activity. We tested the effect of exoenzyme C3 from Clostridium botulinum (C3), a toxin known to ADP-ribosylate and specifically inactivate Rho. C3 led to complete ADP-ribosylation of Rho, and it inhibited carbachol induction of p38 kinase by 50%. We then tested the effect of SB-203580 and C3 on carbachol-stimulated uptake of [(14)C]aminopyrine (AP). Inhibition of p38 kinase by SB-203580 led to a dose-dependent increase in AP uptake induced by carbachol, with maximal (threefold) effect at 10 microM SB-203580. Similarly, preincubation of parietal cells with C3 led to a twofold increase in AP uptake induced by carbachol. Thus carbachol induces a cascade of events in parietal cells that results in activation of p38 kinase through signaling pathways that are at least in part dependent on Rho activation and on the presence of extracellular Ca(2+). p38 kinase appears to inhibit gastric acid secretion. (+info)

Tryptophan operon read-through. Isolation and characterization of an abnormally long tryptophan synthetase alpha subunit from a frame-shift mutant of Escherichia coli. (7/181)

A new mutant strain of Escherichia coli, strain ICR-47, contains a frame-shift mutation in the trpA gene, the gene most distal to the operator in the trp operon. Mapping experiments indicate that the lesion is located at a site within 10 to 15% of the end of this gene. The mutation results in "out-of-phase" translation of the distal portion of the trp mRNA; normal translational termination signal(s) are not encountered and a trpA gene product longer than the wild type protein is produced. As with the other enzymes produced from this operon, the in vivo level of the altered protein (the alpha subunit of the tryptophan synthetase enzyme complex) is controlled by exogenous L-tryptophan. The altered alpha subunit from the strain ICR-47 has been isolated and characterized. Molecular weight estimations indicate a molecular weight of approximately 37,000, an increase beyond the wild type enzyme corresponding to an additional 50 to 70 amino acid residues. The protein has a new COOH-terminal amino acid sequence. Results of preliminary hybridization experiments suggest that the ICR-47 mRNA, which is necessarily longer than that needed to code for wild type enzyme, is not detectably different in size from wild type mRNA. The enzymatic properties of the ICR-47 alpha subunit indicates a greatly reduced ability of the mutant subunit to combine functionally with wild type beta2 subunit, the second protein component in the tryptophan synthetase enzyme complex. In contrast, only 40 to 50% of the intrinsic enzymatic activity of the alpha subunit is lost. (+info)

A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol. (8/181)

Acid secretion in isolated rabbit gastric glands was monitored by the accumulation of [(14)C]aminopyrine. Stimulation of the glands with carbachol synergistically augmented the response to dibutyryl cAMP. The augmentation persisted even after carbachol was washed out and was resistant to chelated extracellular Ca(2+) and to inhibitors of either protein kinase C or calmodulin kinase II. Cytochalasin D at 10 microM preferentially blocked the secretory effect of carbachol and its synergism with cAMP, whereas it had no effect on histamine- or cAMP-stimulated acid secretion within 15 min. Cytochalasin D inhibited the carbachol-stimulated intracellular Ca(2+) concentration ([Ca(2+)](i)) increase due to release from the Ca(2+) store. Treatment of the glands with cytochalasin D redistributed type 3 inositol 1,4,5-trisphosphate receptor (the major subtype in the parietal cell) from the fraction containing membranes of large size to the microsomal fraction, suggesting a dissociation of the store from the plasma membrane. These findings suggest that intracellular Ca(2+) release by cholinergic stimulation is critical for determining synergism with cAMP in parietal cell activation and that functional coupling between the Ca(2+) store and the receptor is maintained by actin microfilaments. (+info)

"Aminopyrine-N-demethylase. I. Directed modification of substrates' structure as a way of production of inducer of the ...

https://en.wikipedia.org/wiki/Ilya_B._Tsyrlov

Aminopyrine Hart FD, Boardman PL (June 1964). "Trial of Nifenazone ("Thylin")". British Medical Journal. 1 (5397): 1553-4. doi: ...

https://en.wikipedia.org/wiki/Nifenazone

In 1897 he invented "Pyramidon", the trade name for aminopyrine. With Arthur Stoll, he is credited with the isolation of ...

https://en.wikipedia.org/wiki/Karl_Spiro

... is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. Due to the risk of ...

https://en.wikipedia.org/wiki/Ampyrone

In 1893, a derivative of antipyrine, aminopyrine, was made by Friedrich Stolz at Hoechst. Yet later, chemists at Hoechst made a ...

https://en.wikipedia.org/wiki/Metamizole

A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in ... Caubet MS, Laplante A, Caillé J, Brazier JL (June 2002). "[13C]aminopyrine and [13C]caffeine breath test: influence of gender, ... Aminophenazone (or aminopyrine, amidopyrine, Pyramidon) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic ...

https://en.wikipedia.org/wiki/Aminophenazone

The compounds generally act as analgesics and include dipyrone (Metamizole), aminopyrine, ampyrone, famprofazone, morazone, ...

https://en.wikipedia.org/wiki/Pyrazolone

Imaoka S, Inoue K, Funae Y (1988). "Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: ... simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography". Arch. Biochem. Biophys. ...

https://en.wikipedia.org/wiki/Unspecific_monooxygenase

... aminopyrine MeSH D03.383.129.539.850.077.025 - ampyrone MeSH D03.383.129.539.850.077.150 - dipyrone (metamizole) MeSH D03.383. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)

... aminopyrine n-demethylase MeSH D08.811.682.662.582.338 - cytochrome p-450 cyp2e1 MeSH D08.811.682.662.582.353 - cytochrome p- ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)

Other names: 3H-Pyrazol-3-one, 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-; Antipyrine, 4-(dimethylamino)-; (Dimethylamino)phenazone; Amidazophen; Amidazophene; Amidofebrin; Amidofen; Amidophen; Amidophenazone; Amidopyrazoline; Amidopyrin; Amidopyrine; Aminophenazon; Aminophenazone; Aminopyrin; Anafebrina; Brufaneuxol; Dereuma; Dimapyrin; Dimethylamino-analgesine; Dimethylaminoantipyrine; Dimethylaminoazophene; Dimethylaminophenyldimethylpyrazolone; Dipirin; Dipyrin; Dipyrine; Febrinina; Febron; Itamidone; Novamidon; Piramidon; Piridol; Piromidina; Polinalin; Pyradone; Pyramidon; Pyramidone; 4-(Dimethylamino)antipyrine; 4-(Dimethylamino)phenazone; 1,5-Dimethyl-2-phenyl-4-dimethylamino-3-pyrazolone; Amidazofen; Eufibron; Hyparon; Mamallet-A; Pirazon; 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone; 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one; 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazolone-5; 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone; ...

https://webbook.nist.gov/cgi/cbook.cgi?ID=58-15-1&Units=SI

Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological ... Aminopyrine metabolism 14CO2-breath test aminopyrine demethylation dose dependent metabolism physical fitness ... Brodie, B.B., Axelrod, J.: The fate of aminopyrine (Pyramidon) in man and methods for the estimation of aminopyrine and its ... Assessment of aminopyrine metabolism in man by breath analysis after oral administration of14C-aminopyrine. Effects of ...

https://link.springer.com/article/10.1007/BF00609866

Aminopyrine; Linear Formula: C13H17N3O; find Sigma-Aldrich-D8015 MSDS, related peer-reviewed papers, technical documents, ...

https://www.sigmaaldrich.com/catalog/product/sigma/d8015?lang=en®ion=US

VALUE OF AMINOPYRINE(VALUE OF AMINOPYRINE*†)(VALUE OF AMINOPYRINE*†) LEONARD CARDON, M.D., F.A.C.P.; OSCAR H. COMESS, M.D.; ... VALUE OF AMINOPYRINE(VALUE OF AMINOPYRINE*†)(VALUE OF AMINOPYRINE*†). Ann Intern Med. 1958;48:616-634. doi: 10.7326/0003-4819- ... Aminopyrine, by force of historical circumstances, has been such a discredited drug for many years.1, 2a, 3c, 4b, 5, 6, 7, 8 ... Quantitative Assessment of Hepatic Function by Breath Analysis after Oral Administration of [14C]aminopyrine Annals of Internal ...

http://annals.org/aim/article/676788/value-aminopyrine

MF:C13H17N3O MW:231.29 CAS:58-15-1 EINECS:200-365-8 Apperance:White fronds crystal or crystalline powder. No smell, taste slightly bitter. Product use: Antipyretic and analgesic, used for fever and headache, joint pain, neuralgia, dysmenorrhea and...

https://www.ecplaza.net/products/aminopyrine-aminophenazone-amidopyrinecas58-15-1_3872768

The effect of a 20-day administration of aminopyrine (600 mg kg-1) as well as two metabolites of aminopyrine, 4-aminoantipyrine ... Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine.. T Satoh, T Igarashi, T ... Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine.. T Satoh, T Igarashi, T ... Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine.. T Satoh, T Igarashi, T ...

https://jpet.aspetjournals.org/content/221/3/795

In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited ... In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited ... In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited ... In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited ...

https://pennstate.pure.elsevier.com/en/publications/characterization-of-cytochrome-p-450-dependent-aminopyrine-n-deme

... to understand the pain of a piece of adverse reactions and pharmacological toxicology Compound Aminopyrine Phenacetin Tablets ( ... Effect of Compound Aminopyrine Phenacetin Tablets on kidney. First, to understand the pain of a piece of adverse reactions and ... This compound contains aminopyrine and phenacetin have obvious adverse reactions. Taking the amino group can vomiting, rash, ... 2 aminopyrine react with food in the stomach, can form carcinogenic N-nitroso compounds, especially nitrosamines, therefore has ...

http://www.kidneyhealthy.com/patcare/2228.html

Aminopyrine breath test predicts surgical risk for patients with liver disease. By R A Gill, M W Goodman, G R Golfus, G R ... To determine whether the [14C] aminopyrine breath test (ABT) predicts surgical risk in patients with liver disease, it was ...

https://core.ac.uk/display/3862174

ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:, Synonyms:AMINOPYRINE , AMINOPHENAZONE CYCLAMATE , AMINOPHENAZONE , ... AMINOPYRINE. ChEMBL Synonyms AMINOPYRINE , AMINOPHENAZONE CYCLAMATE , AMINOPHENAZONE , AMIDOPYRINE. Max Phase. 4 (Approved). ...

https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL288470

Aminopyrine: All drug products containing aminopyrine.. Astemizole: All drug products containing astemizole. ...

https://www.federalregister.gov/documents/2016/10/07/2016-24333/additions-and-modifications-to-the-list-of-drug-products-that-have-been-withdrawn-or-removed-from

14C]aminopyrine accumulation in rabbit isolated gastric glands.. In intact gastric glands from rabbits, histamine significantly ... The following drugs were used in this study: [14C]Aminopyrine (specific activity 96.6 Ci/mmol), [3H]DTG (specific activity 35.2 ... 7). Finally, BDF 6143 up to 100 μM did not alter histamine-induced [14C]aminopyrine accumulation (n = 3; results not shown). ... 7). At this high concentration, clonidine increased [14C]aminopyrine accumulation in 2 of 4 experiments, but because of the ...

http://jpet.aspetjournals.org/content/285/1/170

... score of ascites and result of 14C aminopyrine breath test) were found to be highly effective for making this decision. ...

https://pubmed.ncbi.nlm.nih.gov/2267906/

In rats treated with a single dose [50 mg/kg] of SKF 525-A, aminopyrine N-demethylase and aniline hydroxylase activities were ... The effects of diclofenac sodium administration, in single and repeated doses, on hepatic microsomal activities of aminopyrine ... M, in single and multiple doses on hypatic microsomal aminopyrine n-demethylase and aniline hydroxylase activities in the rat: ... M, in single and multiple doses on hypatic microsomal aminopyrine n-demethylase and anilin ...

https://search.bvsalud.org/gim/resource/en/emr-18894

By using the two different principle methods,the standard value and uncertainty of aminopyrine content was 99.66% ± 0.08%(k = 2 ... The valuation and uncertainty evaluation of the purity determination of aminopyrine by using HPLC and acid-base titration are ... To study the valuation and uncertainty evaluation of the purity determination of aminopyrine by two different principle methods ... Valuation and Uncertainty Evaluation of the Purity Determination of Aminopyrine by Different Methods / 中国药师 ...

https://search.bvsalud.org/gim/resource/en/wprim-705635

Products of Hangzhou Loya Biotechnology Co., Ltd.. TradeKey.com is a B2B marketplace for suppliers, buyers, manufacturers, distributors and resellers

https://jp.tradekey.com/product_listall/uid/10253312/gid/1103432/Hangzhou-Loya-Biotechnology-Co-Ltd-.htm

C.01.131 - Aminopyrine and Dipyrone *C.01.134 - Coated Potassium Salts *C.01.401 - Antibiotics ...

http://laws.justice.gc.ca/eng/regulations/C.R.C.,_c._870/page-121.html

... aminopyrine, 4-aminoantipyrine [244]; minocycline [288]; Tl+ [130, 260], Ag+, H+ [130]; oxybuprocaine, prilocaine, mepivacaine ...

https://www.hindawi.com/journals/ijelc/2012/462197/

Aminopyrine sodium sulfonate; Analgin; Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt; (Antipyrinylmethylamino) ...

https://webbook.nist.gov/cgi/cbook.cgi?ID=68-89-3&Units=SI

Aminopyrine; anafebrina; dimapyrin; ... ...

http://www.frbiz.com/catalog/16260000/dental_equipment.html

Aminopyrine. Phenylbutazone. PTU. Indomethacin. Tocainide 25 What is the antipsychotic drug that causes hypnagogic ...

https://www.brainscape.com/flashcards/parkinsons-and-psychiatric-drugs-1000609/packs/1809744

"Aminopyrine-N-demethylase. I. Directed modification of substrates structure as a way of production of inducer of the ...

https://en.wikipedia.org/wiki/Ilya_B._Tsyrlov

Aminopyrine and its derivatives. Cyclosporine. Amprenavir and its salts and derivatives. Cytarabine and its salts. ...

http://www.bclaws.ca/EPLibraries/bclaws_new/document/ID/freeside/282_2008

Background 14C-aminopyrine accumulation (bg) is also shown. b) Accumulation of 14C-aminopyrine in gastric glands pretreated ... Accumulation of 14C-labeled aminopyrine in db-cAMP-stimulated gastric glands. All values are expressed as percent of a value ... Accumulation of 14C-labeled aminopyrine in histamine-stimulated gastric glands. All values are expressed as percent of the ... Aminopyrine / metabolism. Arginine / pharmacology. Bucladesine / metabolism. Carbon Radioisotopes / metabolism. Enzyme ...

http://www.biomedsearch.com/nih/Nitric-oxide-endogenous-inhibitor-gastric/15298720.html

0 (Biomarkers); 01704YP3MO (Aminopyrine); 76W6J0943E (Flutamide); 822G987U9J (zomepirac); 83HN0GTJ6D (Cyclosporine); D8K2JPN18B ...

http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D03.383.129.578.910

Aminopyrine / analogs & derivatives*. Anemia, Hemolytic / chemically induced*. Child, Preschool. Dipyrone / adverse effects*. ...

http://www.biomedsearch.com/nih/Acute-hemolytic-anemia-induced-by/6438997.html

Comparison of Age-Related Peripheral Nerve Changes in Mice Housed in Either Plastic Cages with Sawdust-Covered Solid Flooring or Wire-Mesh-Floor Cages （2000 ...

https://ci.nii.ac.jp/author?q=KARIYA+Kimio

DEVELOPMENT OF HEPATIC N-DEMETHYLASE ACTIVITY AS MEASURED IN VIVO BY THE AMINOPYRINE BREATH TEST *Robert J Shulman ... Rights & permissionsfor article Effect of Infant Age on Aminopyrine Breath Test Results . Opens in a new window. ... Rights & permissionsfor article DEVELOPMENT OF HEPATIC N-DEMETHYLASE ACTIVITY AS MEASURED IN VIVO BY THE AMINOPYRINE BREATH ... Effect of Infant Age on Aminopyrine Breath Test Results *Robert J Shulman ...

http://www.nature.com/search?author=%22D.%20Klein%22&error=cookies_not_supported&code=3cbbdb62-163f-434e-a673-4ae70279ff17

The effect of aminopyrine on oxygen uptake.Eur. J. Biochem. 10:459-467 (1969).PubMedCrossRefGoogle Scholar ...

https://link.springer.com/article/10.1007/BF01061847

Aminopyrine Hart FD, Boardman PL (June 1964). "Trial of Nifenazone ("Thylin")". British Medical Journal. 1 (5397): 1553-4. doi: ...

https://en.wikipedia.org/wiki/Nifenazone

Under the same experimental condition, the amounts of cytochrome P-450 and b5, the activities of aminopyrine N-demethylase, aniline hydroxylase and carboxylesterase of liver microsomes were all induced in the aminopyrine- and 4-aminoantipyrine-treated rats. (aspetjournals.org)
The effects of diclofenac sodium administration , in single and repeated doses , on hepatic microsomal activities of aminopyrine N- demethylase and aniline hydroxylase were evaluated in rats . (bvsalud.org)
In rats treated with a single dose [50 mg/kg] of SKF 525-A, aminopyrine N-demethylase and aniline hydroxylase activities were significantly decreased, compared with control values. (bvsalud.org)
There was no statistical difference between C / C , C / T , and T / T dogs in activities of aminopyrine N -demethylase, aniline hydroxylase, bufuralol 1′-hydroxylase, and midazolam 1′-hydroxylase. (aspetjournals.org)
Also following dietary administration, hepatic microsomes were isolated and the following parameters related to in vitro drug metabolism were measured, yield of microsomal protein/g liver, in vitro activities of aniline hydroxylase and aminopyrine demethylase, content of cytochromes P-450 and b5/mg microsomal protein. (epa.gov)

The secretory response of the glands was determined as accumulation of [14C]aminopyrine. (biomedsearch.com)
Histamine dose-dependently stimulated the acid formation which was measured as the accumulation of [14C]aminopyrine. (diva-portal.org)
Using this method we studied the effect of CCK-like peptides on [ 14 C]aminopyrine accumulation stimulated by histamine, in order to fmd out whether such peptides can inhibit the production of acid in the parietal cell. (diva-portal.org)
Following culture on Matrigel coated plates, acid secretion was assessed by 14C aminopyrine accumulation. (bmj.com)

First, to understand the pain of a piece of adverse reactions and pharmacological toxicology Compound Aminopyrine Phenacetin Tablets (common name), Somidon piece (formerly common name), compound (phenobarbital + phenacetin caffeine + + amid. (kidneyhealthy.com)
Compound Aminopyrine Phenacetin Tablets (common name), Somidon piece (formerly common name), compound (phenobarbital + phenacetin caffeine + + amidopyrin). (kidneyhealthy.com)

Among them are the fever-reducing analgesic aminopyrine, the anti-inflammatory drug phenylbutazone, used in treating arthritis , the yellow food colour and fibre dye tartrazine, and a series of dyes used as sensitizing agents in colour photography. (britannica.com)

The effects on aminopyrine-demethylase and acetanilide-hydroxylase activity were evaluated. (cdc.gov)
Isooctane did not inhibit aminopyrine-demethylase or acetanilide-hydroxylase activity. (cdc.gov)
The effects on aniline-p-hydroxylase, acetanilide-hydroxylase, and aminopyrine-N- demethylase activity were investigated. (cdc.gov)
IPI and CPI competitively inhibited aniline-p- hydroxylase and acetanilide-hydroxylase and noncompetitively inhibited aminopyrine-N-demethylase, IPI being the more potent. (cdc.gov)

Brodie, B.B., Axelrod, J.: The fate of aminopyrine (Pyramidon) in man and methods for the estimation of aminopyrine and its metabolites in biological material. (springer.com)
The effect of a 20-day administration of aminopyrine (600 mg kg-1) as well as two metabolites of aminopyrine, 4-aminoantipyrine (525 mg kg-1) and 4-acetamidoantipyrine (635 mg kg-1), on several hepatic, kidney and serum enzyme activities were investigated. (aspetjournals.org)

Maximal aminopyrine N-demethylase activity of the brain was 0.5 and 17% that of the liver when expressed per milligram of microsomal protein (261.3 pmol/10 min/mg of protein) and nanomole of cytochrome P-450 (6.98 nmol/10 min/nmol of cytochrome P-450), respectively. (elsevier.com)
protein content (28.4 ± 0.37 and 24.2 ± 4.19 mg/mL) and aminopyrine demethylase activity (2.59 ± 0.08 and 3.48 ± 0.13 µM/g liver/5 min formaldehyde production) checked. (europa.eu)

Gram, T.E., Wilson, J.T., Fouts, J.R.: Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit. (springer.com)
The activity of CYP2H and CYP3A37, enzymes involved in biotransformation in chicken, was detected by aminopyrine N-demethylation and aniline-hydroxylation assays from the microsomal suspensions. (biomedcentral.com)

Hepner, G.W., Vesell, E.S.: Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14 C-aminopyrine. (springer.com)
Depression of aminopyrine metabolism by influenza vaccination. (wikigenes.org)

The medicine industry uses Sodium Bisulfite for manufacturing semifinished product of metamizole sodium and aminopyrine. (alibaba.com)

The single apparent Km of the brain aminopyrine N-demethylase (3.39 mM) was at least 3-fold higher than that of the liver (0.18 and 1.13 mM). (elsevier.com)
Coupled with data presented on the inhibitory effects of CO and SKF 525-A on brain and hepatic aminopyrine N-demethylases, the kinetic data suggest that brain aminopyrine N-demethylase exhibits behavior different from that of the liver enzyme. (elsevier.com)
Aminopyrine breath test predicts surgical risk for patients with liver disease. (core.ac.uk)
To determine whether the [14C] aminopyrine breath test (ABT) predicts surgical risk in patients with liver disease, it was obtained prior to various surgeries in 38 patients with known or suspected liver disease. (core.ac.uk)
Effects of in vivo hyperthermo-chemotherapeutic perfusion of the normal and regenerating liver on the aminopyrine breath test in the rats. (nii.ac.jp)
Clinical evaluation of (13C)-aminopyrine breath test on post-operative prognosis in patients with liver diseases. (nii.ac.jp)
no significant changes were noted in liver aminopyrine - N - demethylase or aniline hydrolase activities. (cdc.gov)
Effects of NKK-105 administration on aminopyrine N-demethylase, cyt.b 5 , cyt.p-45O and lipid peroxidation in CCl 4 -induced liver damage were investigated, in vivo. (go.jp)
Juxtaposition of the phenacetin and aminopyrine stir tests: implication of liver complaint, inducers and cobaltous chloride. (nippon-kan.org)
A Breath Test with 13C-labeled aminopyrine has been used as a non-invasive measure of Cytochrome P-450 metabolic activity in LIVER FUNCTION TESTS. (online-medical-dictionary.org)

This compound contains aminopyrine and phenacetin have obvious adverse reactions. (kidneyhealthy.com)

It is the sodium sulfonate of AMINOPYRINE. (trader-china.com)

Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. (springer.com)
A Pugh score (combining five variables) superior to 8 or a p value inferior to 0.7 of a logistic regression equation containing only two variables (score of ascites and result of 14C aminopyrine breath test) were found to be highly effective for making this decision. (nih.gov)

Lauterburg, B.H., Bircher, J.: Expiratory measurement of maximal aminopyrine demethylation in vivo: effect of phenobarbital, partial hepatectomy, portacaval shunt and bile duct ligation in the rat. (springer.com)

This study was designed to characterize cytochrome P-450-dependent aminopyrine N-demethylation using microsomes from rat brain and to compare it with N-demethylation of the drug by hepatic microsomes studied in parallel. (elsevier.com)
Brain aminopyrine N-demethylation was linear with respect to protein concentrations and incubation times of up to 15 min. (elsevier.com)
In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited linear kinetics. (elsevier.com)

Spectral binding of aminopyrine, hexobarbital, androstenedione and aniline to rat brain cytochrome P-450 could not be detected, apparently because of the low concentration of the hemoprotein. (elsevier.com)

By using the two different principle methods,the standard value and uncertainty of aminopyrine content was 99.66% ± 0.08%(k = 2,P = 0.95). (bvsalud.org)

Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine. (aspetjournals.org)

In vitro assays with model substrates [aminopyrine, aniline, p -nitroanisole, and benzo( a )pyrene] were used to quantitate drug-metabolizing activity. (aacrjournals.org)

In the aminopyrine-treated group, a pronounced induction of gamma-glutamyl transpeptidase was shown in the whole homogenate as compared to that in the hepatic microsomes. (aspetjournals.org)
Aminopyrine N-demethylase of brain microsomes required oxygen and NADPH for optimal activity and its activity was inhibited by carbon monoxide (CO) and SKF 525-A in a concentration-dependent manner. (elsevier.com)

The results in this paper support the view that repeated administration of aminopyrine induces hepatic membrane-bound enzyme, particularly, gamma-glutamyl transpeptidase activity. (aspetjournals.org)

According to Technical Norm of Primary Reference Material and Technical Norm of Measurement,HPLC and acid-base titration were selected for studying the valuation of the purity determination of aminopyrine, and the uncertainty evaluation of the two different principle methods was systematically evaluated. (bvsalud.org)

Serum gamma-glutamyl transpeptidase activity was also increased by administration of aminopyrine or 4-aminoantipyrine. (aspetjournals.org)
NKK-105 had no effect on the activity of aminopyrine N-demethylase and the content of cyt.b5, cyt.p-450 and peroxide. (go.jp)

The valuation and uncertainty evaluation of the purity determination of aminopyrine by using HPLC and acid-base titration are accurate and reliable,which can avoid the defects by using single analysis method,and is helpful to improve the level of quality evaluation and control of aminopyrine. (bvsalud.org)

To study the valuation and uncertainty evaluation of the purity determination of aminopyrine by two different principle methods. (bvsalud.org)

The study provides scientific basis for the development of aminopyrine purity reference materials. (bvsalud.org)

2 aminopyrine react with food in the stomach, can form carcinogenic N-nitroso compounds, especially nitrosamines, therefore has potential carcinogenicity. (kidneyhealthy.com)

Anatomy9

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Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

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Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat. (1/181)

L-365,260 inhibits in vitro acid secretion by interacting with a PKA pathway. (2/181)

Demethylation capacity of human fetal adrenal mitochondrial cytochrome P-450 in vitro. (3/181)

Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. (4/181)

Responsiveness of beta-escin-permeabilized rabbit gastric gland model: effects of functional peptide fragments. (5/181)

Regulation and function of p38 protein kinase in isolated canine gastric parietal cells. (6/181)

Tryptophan operon read-through. Isolation and characterization of an abnormally long tryptophan synthetase alpha subunit from a frame-shift mutant of Escherichia coli. (7/181)

A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol. (8/181)

Aminopyrine

Aminopyrine N-Demethylase

Aniline Hydroxylase

Parietal Cells, Gastric

Microsomes, Liver

Gastric Acid

Antipyrine

Dipyrone

Proadifen

Cytochrome P-450 Enzyme System

Hexobarbital

Peroxides

Pyrazolones

Secobarbital

Glutethimide

Seminal Vesicles

Phenobarbital

Dealkylation

Nitroanisole O-Demethylase

Gastric Mucosa

NADPH-Ferrihemoprotein Reductase

Breath Tests

Histamine

Aniline Compounds

Microsomes

Mixed Function Oxygenases

Semicarbazides

Rats, Inbred Strains

Benzphetamine

Cytochrome Reductases

Liver

H(+)-K(+)-Exchanging ATPase

Anemia, Pernicious

Lipid Peroxides

Carbon Isotopes

Dose-Response Relationship, Drug

Helicobacter Infections

Agranulocytosis

Internal Medicine

Periodicals as Topic

Physicians

Publishing

Dysmenorrhea

Colorimetry

Trigeminal Neuralgia

China

Smell

gamma-Glutamyltransferase

Ampyrone

Glutathione

Imidazoline Receptors

Gastric Fundus

Imidazolines

Idazoxan

Receptors, Drug

Muscle, Smooth

Muscle Contraction

Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat. (1/181)

L-365,260 inhibits in vitro acid secretion by interacting with a PKA pathway. (2/181)

Demethylation capacity of human fetal adrenal mitochondrial cytochrome P-450 in vitro. (3/181)

Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. (4/181)

Responsiveness of beta-escin-permeabilized rabbit gastric gland model: effects of functional peptide fragments. (5/181)

Regulation and function of p38 protein kinase in isolated canine gastric parietal cells. (6/181)

Tryptophan operon read-through. Isolation and characterization of an abnormally long tryptophan synthetase alpha subunit from a frame-shift mutant of Escherichia coli. (7/181)

A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol. (8/181)

Amidopyrine synonyms, amidopyrine antonyms - FreeThesaurus.com

Dose dependence of the14C-aminopyrine breath test | SpringerLink

Characterization of oxyntic glands isolated from the rat gastric mucosa

Aminophenazone - Wikipedia

Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity. | DIAL.pr - BOREAL

VALUE OF AMINOPYRINE*† | Annals of Internal Medicine | American College of Physicians

Aminopyrine Aminophenazone AmidopyrineCAS:58-15-1 - Wuhan Carphetin Chemical Co.,LTD - ecplaza.net

In Vitro Technology - International Society for the Study of Xenobiotics

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$Biotransformation of some pyrazole derivatives to glutathione conjugates in rat liver subcellular fractions.$ Biotransformation of some pyrazole derivatives to glutathione conjugates in rat liver subcellular fractions.

$Gentaur Molecular :Nacala \ Aniline \ 02915-25$ Gentaur Molecular :Nacala \ Aniline \ 02915-25