Aminopyrine: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.Aminopyrine N-DemethylaseAniline Hydroxylase: A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.Parietal Cells, Gastric: Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Gastric Acid: Hydrochloric acid present in GASTRIC JUICE.Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)Dipyrone: A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.Peroxides: A group of compounds that contain a bivalent O-O group, i.e., the oxygen atoms are univalent. They can either be inorganic or organic in nature. Such compounds release atomic (nascent) oxygen readily. Thus they are strong oxidizing agents and fire hazards when in contact with combustible materials, especially under high-temperature conditions. The chief industrial uses of peroxides are as oxidizing agents, bleaching agents, and initiators of polymerization. (From Hawley's Condensed Chemical Dictionary, 11th ed)Pyrazolones: Compounds with a five-membered heterocyclic ring with two nitrogens and a keto OXYGEN. Some are inhibitors of TNF-ALPHA production.Secobarbital: A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity.Glutethimide: A hypnotic and sedative. Its use has been largely superseded by other drugs.Seminal Vesicles: A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.Dealkylation: The removing of alkyl groups from a compound. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Nitroanisole O-Demethylase: Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.NADPH-Ferrihemoprotein Reductase: A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.Breath Tests: Any tests done on exhaled air.Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Aniline CompoundsMicrosomes: Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Mixed Function Oxygenases: Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.SemicarbazidesRats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Benzphetamine: A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)Cytochrome ReductasesLiver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.H(+)-K(+)-Exchanging ATPaseAnemia, Pernicious: A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)Lipid Peroxides: Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.

Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat. (1/181)

Despite its hepatotoxic potential, cyclosporine A (CsA) has been reported to positively influence compensatory liver growth. To probe the physiological consequences of CsA on the recovery of liver function, studies were initiated in the 2/3 partially hepatectomized (PHx) rat, taking the recovery of cytochromes P-450-dependent drug metabolism as primary outcome. CsA was administered at a dose of 3. 33 mg/kg/day for 10 days. Drug metabolism was evaluated by the recovery of 14CO2 after administration of isotopically labeled model drugs and by studying the expression of the P-450 transcripts involved in their biotransformation before and 24 to 96 h after PHx. Before PHx, neither the steady-state mRNA nor the in vivo disposition of caffeine (CYP1A2), erythromycin (CYP3A2 and 3A1), or aminopyrine (CYP2B1 and 2C11) were influenced by CsA. Studies 24 h after PHx revealed a 29 to 39% reduction in the elimination of [14C]aminopyrine and [14C]erythromycin, which was unaffected by CsA. Their metabolism at 48 to 96 h after PHx also remained unaffected by CsA. By contrast, postPHx, [14C]caffeine elimination decreased to a level closely proportional to the loss in liver mass. In addition, CsA accelerated the recovery and/or prevented the decrease of caffeine elimination 24 h after PHx but not at later time points, indicating an early, but unsustained, beneficial effect of CsA on the recovery of CYP1A2-mediated activities. These data show that at the critical time of greatest loss in liver mass, CsA has only a selective influence on the biotransformation of cytochrome P-450 protein-dependent activities and that its effect on the regeneration process does not translate into an overall accelerated recovery of the hepatic drug-metabolizing function.  (+info)

L-365,260 inhibits in vitro acid secretion by interacting with a PKA pathway. (2/181)

The aim of this study was to analyse the antisecretory mechanism of L-365,260 in vitro in isolated rabbit gastric glands. We showed that compound L-365,260, described as a non-peptide specific competitive CCK-B receptor antagonist, was able to dose-dependently inhibit [14C]-aminopyrine accumulation induced by histamine (10(-4) M), carbachol (5x10(-5) M), 3-isobutyl-1-methyl-xanthine (IBMX) (5x10(-6) M) and forskolin (5x10(-7) M) with similar IC50 values respectively of 1.1+/-0.6x10(-7) M, 1.9+/-1.2x10(-7) M, 4.2+/-2.0x10(-7) M and 4.0+/-2.8x10(-7) M. We showed that L-365,260 acted beyond receptor activation and production of intracellular second messengers and that it had no action on the H+/K+ -ATPase. We found that L-365,260 inhibited cyclic AMP-induced [14C]-aminopyrine accumulation in digitonin-permeabilized rabbit gastric glands, suggesting that this compound acted, at least in part, as an inhibitor of the cyclic AMP-dependent protein kinase (PKA) pathway.  (+info)

Demethylation capacity of human fetal adrenal mitochondrial cytochrome P-450 in vitro. (3/181)

AIM: To explore the capacity and characteristics of adrenal mitochondria to metabolize xenobiotics in vitro in human fetus. METHODS: Subcellular fractions of fetal adrenal were prepared by differential centrifugation. Mitochondrial P-450 system was proved by spectral analyses and SDS-PAGE. The formaldehyde formation contents were measured with Nash reagent. RESULTS: The erythromycin N-demethylation linearly increased in the protein concentration (1-4 mg)- and incubation time (10-30 min)-dependent manners. A typical concentration-effect relationship appeared with erythromycin 0.067-1 mmol.L-1 and a positive correlation (r = 0.641, P < 0.05) existed between erythromycin N-demethylation and gestation months. The N-demethylation values (nmol.s-1/g protein) of erythromycin (2.7 +/- 0.8), benzfetamine (1.1 +/- 0.5), and aminophenazone (0.9 +/- 0.4) in mitochondria were 89% (P > 0.05), 162% (P < 0.01), and 62% (P < 0.01), respectively, of those in microsomes. There was correlation between mitochondria and microsomes in the N-demethylation of erythromycin (r = 0.708, P < 0.05) and benzfetamine (r = 0.707, P < 0.05). Troleandomycin stimulated erythromycin N-demethylation in adrenal mitochondria as well as in adrenal and liver microsomes in vitro. CONCLUSION: Fetal adrenal mitochondria, with multiple P-450 isoforms and greater capacity of demethylation, play a role in drug-metabolism during fetal development.  (+info)

Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. (4/181)

Stimulation of the gastric parietal cell results in a massive redistribution of H+-K+-ATPase from cytoplasmic tubulovesicles to the apical plasma membrane. Previous studies have implicated the small GTPase rab11 in this process. Using matrix-assisted laser desorption mass spectrometry, we confirmed that rab11 is associated with H+-K+-ATPase-enriched gastric microsomes. A stoichiometry of one rab11 per six copies of H+-K+-ATPase was estimated. Furthermore, rab11 exists in at least three forms on rabbit gastric microsomes: the two most prominent resemble rab11a, whereas the third resembles rab11b. Using an adenoviral expression system, we expressed the dominant negative mutant rab11a N124I in primary cultures of rabbit parietal cells under the control of the tetracycline transactivator protein (tTA). The mutant was well expressed with a distribution similar to that of the H+-K+-ATPase. Stimulation of these cultures with histamine and IBMX was assessed by measuring the aminopyrine (AP) uptake relative to resting cells (AP index). In experiments on six culture preparations, stimulated uninfected cells gave an AP index of 10.0 +/- 2.9, whereas parallel cultures expressing rab11a N124I were poorly responsive to stimulation, with a mean AP index of 3.2 +/- 0. 9. Control cultures expressing tTA alone or tTA plus actin responded equally well to stimulation, giving AP index values of 9.0 +/- 3.1 and 9.6 +/- 0.9, respectively. Thus inhibition by rab11a N124I is not simply due to adenoviral infection. The AP uptake data were confirmed by immunocytochemistry. In uninfected cells, H+-K+-ATPase demonstrated a broad cytoplasmic distribution, but it was cleared from the cytoplasm and associated with apically derived membranes on stimulation. In cells expressing rab11a N124I, H+-K+-ATPase maintained its resting localization on stimulation. Furthermore, this effect could be alleviated by culturing infected cells in the presence of tetracycline, which prevents expression of the mutant rab11. We therefore conclude that rab11a is the prominent GTPase associated with gastric microsomes and that it plays a role in parietal cell activation.  (+info)

Responsiveness of beta-escin-permeabilized rabbit gastric gland model: effects of functional peptide fragments. (5/181)

We established a beta-escin-permeabilized gland model with the use of rabbit isolated gastric glands. The glands retained an ability to secrete acid, monitored by [14C]aminopyrine accumulation, in response to cAMP, forskolin, and histamine. These responses were all inhibited by cAMP-dependent protein kinase inhibitory peptide. Myosin light-chain kinase inhibitory peptide also suppressed aminopyrine accumulation, whereas the inhibitory peptide of protein kinase C or that of calmodulin kinase II was without effect. Guanosine-5'-O-(3-thiotriphosphate) (GTPgammaS) abolished cAMP-stimulated acid secretion concomitantly, interfering with the redistribution of H+-K+-ATPase from tubulovesicles to the apical membrane. To identify the targets of GTPgammaS, effects of peptide fragments of certain GTP-binding proteins were examined. Although none of the peptides related to Rab proteins showed any effect, the inhibitory peptide of Arf protein inhibited cAMP-stimulated secretion. These results demonstrate that our new model, the beta-escin-permeabilized gland, allows the introduction of relatively large molecules, e.g., peptides, into the cell, and will be quite useful for analyzing signal transduction of parietal cell function.  (+info)

Regulation and function of p38 protein kinase in isolated canine gastric parietal cells. (6/181)

We examined the regulation and functional role of p38 kinase in gastric acid secretion. p38 kinase was immunoprecipitated from cell lysates of highly purified gastric parietal cells in primary culture, and its activity was quantitated by in vitro kinase assay. Carbachol effects were dose- and time-dependent, with a maximal 10-fold stimulatory effect detected after 30 min of incubation. SB-203580, a highly selective inhibitor of p38 kinase, blocked carbachol induction of p38 kinase activity, with maximal inhibition at 10 microM. Stimulation by carbachol was unaffected by preincubation of parietal cells with the intracellular Ca(2+) chelator BAPTA-AM, but incubation of cells in Ca(2+)-free medium led to a 50% inhibition of carbachol induction of p38 kinase activity. Because some of the effects of carbachol are mediated by the small GTP-binding protein Rho, we examined the role of Rho in carbachol induction of p38 kinase activity. We tested the effect of exoenzyme C3 from Clostridium botulinum (C3), a toxin known to ADP-ribosylate and specifically inactivate Rho. C3 led to complete ADP-ribosylation of Rho, and it inhibited carbachol induction of p38 kinase by 50%. We then tested the effect of SB-203580 and C3 on carbachol-stimulated uptake of [(14)C]aminopyrine (AP). Inhibition of p38 kinase by SB-203580 led to a dose-dependent increase in AP uptake induced by carbachol, with maximal (threefold) effect at 10 microM SB-203580. Similarly, preincubation of parietal cells with C3 led to a twofold increase in AP uptake induced by carbachol. Thus carbachol induces a cascade of events in parietal cells that results in activation of p38 kinase through signaling pathways that are at least in part dependent on Rho activation and on the presence of extracellular Ca(2+). p38 kinase appears to inhibit gastric acid secretion.  (+info)

Tryptophan operon read-through. Isolation and characterization of an abnormally long tryptophan synthetase alpha subunit from a frame-shift mutant of Escherichia coli. (7/181)

A new mutant strain of Escherichia coli, strain ICR-47, contains a frame-shift mutation in the trpA gene, the gene most distal to the operator in the trp operon. Mapping experiments indicate that the lesion is located at a site within 10 to 15% of the end of this gene. The mutation results in "out-of-phase" translation of the distal portion of the trp mRNA; normal translational termination signal(s) are not encountered and a trpA gene product longer than the wild type protein is produced. As with the other enzymes produced from this operon, the in vivo level of the altered protein (the alpha subunit of the tryptophan synthetase enzyme complex) is controlled by exogenous L-tryptophan. The altered alpha subunit from the strain ICR-47 has been isolated and characterized. Molecular weight estimations indicate a molecular weight of approximately 37,000, an increase beyond the wild type enzyme corresponding to an additional 50 to 70 amino acid residues. The protein has a new COOH-terminal amino acid sequence. Results of preliminary hybridization experiments suggest that the ICR-47 mRNA, which is necessarily longer than that needed to code for wild type enzyme, is not detectably different in size from wild type mRNA. The enzymatic properties of the ICR-47 alpha subunit indicates a greatly reduced ability of the mutant subunit to combine functionally with wild type beta2 subunit, the second protein component in the tryptophan synthetase enzyme complex. In contrast, only 40 to 50% of the intrinsic enzymatic activity of the alpha subunit is lost.  (+info)

A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol. (8/181)

Acid secretion in isolated rabbit gastric glands was monitored by the accumulation of [(14)C]aminopyrine. Stimulation of the glands with carbachol synergistically augmented the response to dibutyryl cAMP. The augmentation persisted even after carbachol was washed out and was resistant to chelated extracellular Ca(2+) and to inhibitors of either protein kinase C or calmodulin kinase II. Cytochalasin D at 10 microM preferentially blocked the secretory effect of carbachol and its synergism with cAMP, whereas it had no effect on histamine- or cAMP-stimulated acid secretion within 15 min. Cytochalasin D inhibited the carbachol-stimulated intracellular Ca(2+) concentration ([Ca(2+)](i)) increase due to release from the Ca(2+) store. Treatment of the glands with cytochalasin D redistributed type 3 inositol 1,4,5-trisphosphate receptor (the major subtype in the parietal cell) from the fraction containing membranes of large size to the microsomal fraction, suggesting a dissociation of the store from the plasma membrane. These findings suggest that intracellular Ca(2+) release by cholinergic stimulation is critical for determining synergism with cAMP in parietal cell activation and that functional coupling between the Ca(2+) store and the receptor is maintained by actin microfilaments.  (+info)

*Aminophenazone

A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in ... Aminophenazone (or aminopyrine, amidopyrine, Piramidon) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic ... Caubet, M. S.; Laplante, A.; Caillé, J.; Brazier, J. L. (4 Jan 2007). "[13C]Aminopyrine and [13C]Caffeine Breath Test: ...

*Nifenazone

Aminopyrine Hart, F. D.; Boardman, P. L. (1964). "Trial of Nifenazone ("thylin")". British Medical Journal. 1 (5397): 1553-1554 ...

*Karl Spiro

In 1897 he invented "Pyramidon", the trade name for aminopyrine. With Arthur Stoll, he is credited with the isolation of ...

*Ampyrone

... is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. Due to the risk of ...

*Metamizole

In 1893, a derivative of antipyrine, aminopyrine, was made by Friedrich Stolz at Hoechst. Yet later, chemists at Hoechst made a ...

*Pyrazolone

The compounds generally act as analgesics and include dipyrone (Metamizole), aminopyrine, ampyrone, famprofazone, morazone, ...

*Unspecific monooxygenase

Imaoka S, Inoue K, Funae Y (1988). "Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: ... simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography". Arch. Biochem. Biophys. ...

*List of MeSH codes (D03)

... aminopyrine MeSH D03.383.129.539.850.077.025 --- ampyrone MeSH D03.383.129.539.850.077.150 --- dipyrone (metamizole) MeSH ...

*Paracetamol

... an aminopyrine derivative of aspirin, caffeine, and sometimes a barbiturate. Paracetamol is the active metabolite of phenacetin ...

*List of MeSH codes (D08)

... aminopyrine n-demethylase MeSH D08.811.682.662.582.338 --- cytochrome p-450 cyp2e1 MeSH D08.811.682.662.582.353 --- cytochrome ...

*Ethyl acetoacetate

... antipyrine and aminopyrine, and vitamin B1; as well as the manufacture of dyes, inks, lacquers, perfumes, plastics, and yellow ...
Synonyms for amidopyrine in Free Thesaurus. Antonyms for amidopyrine. 1 synonym for amidopyrine: aminopyrine. What are synonyms for amidopyrine?
Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. Nine volunteers were given14...
The design of methods useful for the preparation of viable glands and cells from the gastric mucosa allowed detailed studies on the mechanisms that regulate gastric acid secretion. The preparation of rabbit gastric glands was the first suitable method to be used and a number of important scientific contributions have been accomplished with this method. Using this method we studied the effect of CCK-like peptides on [14C]aminopyrine accumulation stimulated by histamine, in order to fmd out whether such peptides can inhibit the production of acid in the parietal cell. We also developed a method for the study of viable rat gastric glands that allowed comparative studies in the rat species.. In rabbit gastric glands CCK-like pep tides inhibited histamine stimulated acid formation whereas gastrin peptides were ineffective. The most potent and efficacious peptides were CCK 8 and the cholecystokinetic amphibian decapeptide cemlein reducing the maximal histamine stimulation of aminopyrine accumulation ...
Aminophenazone (or aminopyrine, amidopyrine, Piramidon) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests. It is also used in measuring the total body water in the human body system. Production and use have been banned in France, Thailand and India. Symptoms of exposure to this compound include: allergic reactions strong spasmolytic effect on smooth muscle of peripheral blood vessels irritability palsy copious sweating dilated pupils sharp drop then rise in body temperature dysuria dyspnea anxiety tenesmus[disambiguation needed] urinary frequency intermittent fever fatty infiltration of the liver heart muscle degeneration death due to circulatory failure following cardiovascular collapse Agranulocytosis often occurs. Ingestion may cause central nervous system stimulation, vomiting, ...
Dietary habits are often considered as a pathogenic factor for fatty liver. The impact of dietary intake and steatosis on drug metabolism remains poorly investigated. Our aim was to assess the effect of dietary intake on in vivo cytochrome P450 (CYP) activities in eleven patients with abnormal liver function tests potentially due to fatty liver and associated with a high-sugar diet. Liver function tests, liver volume, aminopyrine breath test (ABT) and chlorzoxazone (CZ) pharmacokinetics (area under the curve, AUC) which are known to reflect CYP2E1 activity were evaluated before and after 2 months restriction of dietary sugar intake. Features at inclusion were an increased BMI (30.3 (SD 3.2) kg/m2), high hepatic volume (1.96 (SD 0.48) litres), hyperechogenic liver parenchyma, elevated liver enzyme activities (alanine aminotransferase (EC 2.6.1.2) 58.6 (SD 17.4) IU/1 with alanine aminotransferase: aspartate aminotransferase (EC 2.6.1.1) ratio , 1), together with a normal ABT value (0.68 (SD 0.21)% ...
Modern medical science has made such tremendous strides in the field of therapeutics that many older drugs, especially if potentially productive of untoward and dangerous side-effects, have been discredited and have fallen into disuse. Admittedly, many such drugs have marked therapeutic value and are deserving of further investigation and clinical trial before they are completely discarded.. Aminopyrine, by force of historical circumstances, has been such a discredited drug for many years.1, 2a, 3c, 4b, 5, 6, 7, 8 The danger of agranulocytosis resulting from its use is real and well established, but undoubtedly has been overemphasized.1, 2a, 4b, 5, 6, ...
MF:C13H17N3O MW:231.29 CAS:58-15-1 EINECS:200-365-8 Apperance:White fronds crystal or crystalline powder. No smell, taste slightly bitter. Product use: Antipyretic and analgesic, used for fever and headache, joint pain, neuralgia, dysmenorrhea and...
With that encouragement Axelrod quickly showed that amphetamine was rapidly metabolized in rabbit liver slices. He went on to define the co-factor requirements for the reaction finding that NADPH was required; similar to observations of Bert LaDu in his studies on aminopyrine demethylation9.Axelrod then determined the sub-cellular location of the activity by using methods developed by Hogeboom and Schneider10. This newly defined microsomal oxidizing system was soon shown to be responsible for the metabolism of a wide variety of drugs and other chemicals.. Ref: 1V.R.Potter and C.A.Elvehjem, J.Biol. Chem. ,114:495-504 (1936) 2A.Claude, Cold String Harbor Symposium Quant.Biol.,9:263-270 (1941)3 W.C.Schneider,J.Biol.Chem. 165:585-593 (1949) 4E.C.Miller and J.A.Miller, Cancer Res. 7:468-480 (1947)5 E.S.Stevenson, K. Dobriner, and C.P.Rhoads, Cancer Research 2:160-167 (1942)6 G.C.Mueller and J.A.Miller, J.Biol.. Chem. 176:535-544 (1948) 7G.C.Mueller and J.A. Miller, J.Biol. Chem. ,180:1125-1236 ...
The involvement of a thromboxane (TX) A2-like substance in the decrease of mucosal blood flow (MBF) and occurrence of gastric erosions in rats under water-immersion stress was examined. MBF was estimated by aminopyrine clearance. Stress increased acid output without a parallel increase in MBF and caused erosions. OKY-046, an inhibitor of TXA2 synthesis, and ONO-11120, an antagonist of TXA2 receptors, increased MBF during stress in parallel with an increase in acid output, and erosions did not form. In another experiment, the effects of a TXA2-like substance on MBF during vagal stimulation were examined. Although vagal stimulation alone increased acid output, there were no erosions in the stomach, probably because MBF was increased in parallel with acid output. Intra-arterial administration of a TXA2-like substance formed by the metabolism of arachidonic acid in the blood reduced MBF during vagal stimulation. Intra-arterial administration of ONO-11113, an agonist of TXA2 receptors, also reduced ...
Near rhymes (words that almost rhyme) with polystyrene: styrene, aminopyrine, trireme, tetracycline... Find more near rhymes/false rhymes at B-Rhymes.com
BR-4935: cardiotonic; a non-adenosine analog adenosine1-receptor agonist with a substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyrine
A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has Risk of Agranulocytosis. A Breath Test with 13C-labeled aminopyrine has been used as a non-invasive measure of Cytochrome P-450 metabolic activity in LIVER FUNCTION TESTS ...
The effect of ethanol on N-demethylation of aminopyrine in rat liver slices and in the microsomal fraction and on microsomal hydroxylation of pentobarbital and aniline was studied. With liver slices N-demethylation of aminopyrine was stimulated by 35-40% at low ethanol concentrations (2mm), whereas no stimulation occurred at high concentrations (100mm). With the liver microsomal fraction, an inhibitory effect was observed only at high ethanol concentrations (100mm). This was also observed with the other drugs studied. In agreement with these results, only at a high concentration did ethanol interfere with the binding of drug substrates to cytochrome P-450. Further, as previously reported, ethanol produced a reverse type I spectral change when added to the liver microsomal fraction. Evidence that this spectral change is due to removal of substrate, endogenously bound to cytochrome P-450, is reported. A dual effect of ethanol is assumed to explain the present findings; in liver slices, at a low ...
H(+)-K(+)-adenosinetriphosphatase (H(+)-K(+)-ATPase) is the principal enzyme responsible for the process of gastric acid secretion. This enzyme is expressed in a cell-type-specific manner in gastric parietal cells. To explore the mechanisms regulating its expression, we transfected differentiated canine parietal cells in primary culture with H(+)-K(+)-ATPase-luciferase reporter genes and assessed transcriptional activities. Deletional analysis of the 5-flanking region of this gene demonstrated a remarkable increment in transcriptional activity associated with a segment between bases -54 to -45 (5 GCTCCGCCTC 3) relative to the transcriptional initiation site. Gel shift assays with competition and supershift analysis demonstrated that this segment is specifically bound by the transcription factor Sp1. A point mutation, eliminating Sp1 binding, diminished basal transcriptional activity by 80%, indicating that this Sp1 binding site is important for constitutive transcriptional activity. Although ...
Gold, M.S. and Ziegler, D.M. Dimethylanilin N-oxidase and aminopyrine N-demethylase activities of human liver tissue. Xenobiotica, 3(3): 179-189, 1972 ...
Chemicals - Coatings China, Formic Acid Rubber Pulp Disinfest, Uses: 1. Pharmaceutical industry: Caffeine, Enzimes, Aminopyrine, Vitamin B1 2. Pesticide industry: Triazolone, Disinfes...
Maintaining healthy cells is the key to experimental success and reproducible research results. To give you confidence in the health of your cells every step of the way, weve highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. No matter how you are using your cells, you can count on these products to help keep them healthy.. ...
The project is aimed on research and development of the methods for storing, searching and processing of the information taking into account of its complex structure and spatio-temporal semantics. In the scope of the project the decomposition method base on dynamic octrees should be developed and investigated, their complexity should be estimated and recommendations for its practical usage should be elaborated.. ...
The gastric autoantigens. The two autoantigens targeted by autoantibodies are components unique to the gastric parietal cell in the. Figure 1 The gastric parietal cell antibody detected by immunofluorescence and illustrated here on murine gastric mucosa reacts with the cytoplasm of gastric parietal cells. Characteristic of the Immunofluorescence reaction is the denser staining of the newly formed cells at the base of the mucosa (bottom left) and lighter staining of the mature cells towards the top of the mucosa. Experimental evidence suggests that the autoantigen in the parietal cell is the enzyme H+,K*-ATPase which is involved in production of acid secreted into the gastric juice.. body of the stomach. The autoantigen with which GPCA reacts is the enzyme H+,K+-adenosine triphosphatase (H+,K+-ATPase) which is cell-specific but not species-specific, indicating the importance of the physiologic role of the molecule in the gastric parietal cell. The second autoantigen is a secreted product of the ...
Serum triglycerides are hydrolyzed to glycerol and free fatty acids by lipase. In the presence of ATP and glycerol kinase (GK), the glycerol is converted to glycerol-1-phosphate. The glycerol-1-phosphate is then oxidized by glycerol phosphate oxidase (GPO) to yield hydrogen peroxide. The condensation of hydrogen peroxide with 4-chlorophenol and 4-aminophenazone (4-AA) in the presence of peroxidase (POD) produces a red colored quinonimine dye which absorbs at, or near 500nm. The intensity of the colored complex formed is directly proportional to the triglycerides concentration of the sample ...
Quick Search Product Directory Listing in Alphabetical IndexP on Drugdu.com for Paediatric Compound Sulfamethoxazole Tablets|||206049|||british-mai-worldcom-hebi-pharmaceutical-company-limited, Paracetamol Caffeine and Aspirin Powder|||206041|||british-mai-worldcom-hebi-pharmaceutical-company-limited, Pediatric Paracetamol Aminophenazone Caffeine and Chlorphenamine Maleate Granules|||206033|||british-mai-worldcom-hebi-pharmaceutical-company-limited and more.
A stylized view of a parietal cell. Parietal cells are found in the proximal portions of the gastric glands of the stomach and secrete HCl and intrinsic factor. - Stock Image F002/0341
The development of several hepatic microsomal drug-metabolizing enzyme activities in rats was studied in relation to its androgen dependence during the neonatal period. Rats with their androgen deprived during the neonatal period (female rats and male rats castrated at birth) respond less to androgen treatment at adulthood for the metabolism of aminopyrine, ethylmorphine and hexobarbital as compared to rats exposed to neonatal androgen (male rats, male rats castrated at birth but neonatally treated with androgen and male rats castrated at the age of 20 days). This difference in the degree of hepatic responsiveness, however, varied with the substrates: ethylmorphine N-demethylase activity was affected the most whereas aminopyrine N-demethylase and hexobarbital oxidase activities were only marginally affected. Furthermore, these differences in responsiveness seem to be a delayed event, since hepatic aminopyrine N-demethylase activity in rats castrated at birth did respond to androgen stimulation ...
Looking for online definition of proper gastric gland in the Medical Dictionary? proper gastric gland explanation free. What is proper gastric gland? Meaning of proper gastric gland medical term. What does proper gastric gland mean?
Gastric gland: false-colour scanning electron micrograph (SEM) of the mucous membrane lining the stomach, showing the shadowy entrances to a number of gastric glands. The glands secrete gastric juice (hydrochloric acid & the enzyme pepsin) and a protective mucous, derived from the simple, columnar cells (moss-like) that comprise the mucosa. Gastric glands are formed by simple invagination or tubular ingrowth of this mucosa into the underlying layer of tissue, the lamina propria. Magnification: x300 at 6x7cm size. - Stock Image P510/0042
Diphenylhydantoin (DPH) treatment increased hepatic drug metabolism of 5-and 10-day-old neonatal rats. In vitro metabolism was measured using the 9000 x g supernatant fraction as the enzyme source. Neonatal hepatic metabolism of p-nitroanisole, hexobarbital, benzphetamine, aminopyrine and -nitrobenzoic acid was significantly increased by DPH treatment. DPH treatment increased neonatal liver weight, but did not alter microsomal protein content per gram of liver or the ability of the 9000 x g supernatant fraction to generate reduced nicotinamide adenine dinucleotide phosphate (NADPH). Likewise, DPH treatment of adult rats significantly increased hepatic metabolism of benzphetamine and aminopyrine. Regardless of animal age, aniline hydroxylase and benzpyrene hydroxylase were apparently unaffected by DPH treatment. The amount of hepatic microsomal cytochrome P-450 was significantly increased, but cytochrome b5 was unaffected by DPH treatment of all age groups. Rat liver microsomal P-450 was ...
Abstract: Metabolism of aminopyrine, sodium benzoate and toxicity of cyclophosphamide were studied in 185 male rats under conditions of various content of vitamin B1 in the animals. Deficiency of thiamin led to an increase in excretion of 4-aminoantipyrine and especially of its acetylated derivative. After administration of thiamin metabolism of aminopyrine was not distinctly altered, while thiamin diphosphate inhibited the drug biotransformation. In deficiency of vitamin B1 transformation of benzoic acid into hippuric acid was inhibited but formation of glucuronides was elevated. Administration of thiamin or thiamin diphosphate stimulated the benzoic acid conjugation and inhibited the glucuronides formation. Deficiency of vitamin B1 accelerated the cyclophosphamide toxicity. Preadministration of thiamin and especially of thiamin diphosphate decreased the toxic effect of cyclophosphamide ...
Left resting in the trunk of the Dumbow (one of the elephant parade elephants) just outside Urban Outfitters. I thought it was appropriate to leave this book with an Ele who looks like hes on acid... ...
Gentaur molecular products has all kinds of products like :search , Biovis \ ABT_869 \ 1615-1 for more molecular products just contact us
How does IPL work for acne?. There are three forms of IPL therapy for acne - LHE Therapy, Blue-Light Therapy and IPL with medication. The choice will depend on what results youre looking for and what your dermatologist suggests as the most effective for your individual acne spots. LHE therapy uses both heat and light as the source to treat acne. The FDA has actually approved one IPL treatment that involves green light waves and heat. This form of IPL is meant to treat mild to moderate acne and more than likely, over a period of time. The whole process has been known to reduce the size of oil glands and kill the dirt bacteria in pores that create acne.. Blue-Light therapy is similar to LHE minus the UV radiation. It only makes sense that less UV radiation equals less damage on your skin. This form of IPL will have the same effect on killing the dirt bacteria but with less side effects than the LHE therapy. According to Robin McClain, who is a registered nurse practitioner from the University of ...
During incubation of antipyrine, but not amidopyrine, 4-aminoantipyrine and 4-leucylaminoantipyrine, with rat liver microsomaland cytosol fractions in the presence of NADPH-generating system a reactive metabolite, which binds with glutathione is form
Home » Dipyrone. Dipyrone (Science: chemical) ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1h-pyrazol-4-yl)methylamino)methanesulfonic acid. A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of aminopyrine. Because of the risk of serious adverse effects its use is justified only in serious situations where no alternative is available or suitable. Pharmacological action: non-steroidal anti-inflammatory agents. chemical name: Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-, sodium salt ...
It catalyzes transport of H+ out of the gastric parietal cell (toward the stomach lumen) in exchange for K+ entering the cell. how the Sodium Potassium Pump works. ...
Pep*sin o*gen, n. [Pepsin + gen.] (Physiol. Chem.) The antecedent of the ferment pepsin. A substance contained in the form of granules in the peptic cells of the gastric glands. It is readily convertible into pepsin. Also called {propepsin}.…
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Clotrimazole, an N-substituted imidazole widely used as an antifungal agent, has been shown to both inhibit and induce hepatic cytochrome P-450 and related monooxygenase activities. In this study the profile of hepatic cytochrome P-450 isozyme(s) induced by clotrimazole treatment of male Sprague-Dawley rats was investigated. Clotrimazole administration (100 mg/kg, daily for 4 days, ig) resulted in 86% induction of spectrally detectable cytochrome P-450 in hepatic microsomes. In these microsomes 7-ethoxycoumarin O-deethylase (126%), aminopyrine N-demethylase (176%), benzphetamine N-demethylase (117%), p-nitrophenol hydroxylase (89%), and 7-ethoxyresorufin O-deethylase (62%) activities were significantly induced, whereas aryl hydrocarbon hydroxylase activity remained unchanged. Characterization of cytochrome P-450 isozyme(s) in hepatic microsomes prepared from clotrimazole-treated animals was based on the immunoreactivity of these microsomes with highly specific monoclonal antibodies (MAbs) raised ...
Biochemical, histopathological and ultrastructural changes occurring at different time points after intraperitoneal administration of a single dose of pulegone (300 mg/kg) were studied. Significant decreases in the level of liver microsomal cytochrome P-450 (67%), heme (37%), aminopyrine N-demethylase (60%) and glucose-6-phosphatase (58%), were noticed 24 hr after pulegone treatment. Alanine amino transferase (ALT) levels increased in a time dependent manner, following exposure of rats to pulegone. Light microscopic studies of liver tissues showed dilation of central veins and distention of sinusoidal spaces 6 hr after pulegone treatment. Initial centrilobular necrosis was noticed at 12 hr. Centrilobular necrosis became severe at 18 hr and nuclear changes included karyorrhexis and karyolysis. Midzonal and periportal degenerative changes in addition to centrilobular necrosis was observed 24 hr after pulegone administration. Electron microscopic changes showed severe degeneration of endoplasmic ...
Unscramble aniline, Unscramble letters aniline, Point value for aniline, Word Decoder for aniline, Word generator using the letters aniline, Word Solver aniline, Possible Scrabble words with aniline, Anagram of aniline
A boozy joiner who refused a breath test when police stopped him pushing his broken-down van along a Sutton street narrowly escaped a driving ban, a court heard.
Breath Test Evidence explained by the Frim that Authors the DUI Practice Manual for Washington State. Call today for more information (206) 866-6739
My 16 year old son refused to take a breath test and asked for his parents. The officer detained him in handcuffs. What are my sons rights in this situation?
John McLaren-Howard has again come up with a brilliant suggestion for a simple test to diagnose hypochlorhydria. The idea here is that it is very difficult for the stomach to produce stomach acid. The normal acidity of blood is about pH7, but the acidity of stomach acid can be as low as pH 2 or below. That means that hydrogen ions (which create acidity) are a 100,000 times more concentrated in the stomach than in the bloodstream. So the stomach wall has a very difficult job to do. The gastric parietal cells need quite a bit of energy from ATP to pump hydrogen ions from the inside of the parietal cell into the lumen of the stomach. The difficult bit is stopping these hydrogen ions leaking back again. This is achieved because the gastric parietal cells forming a protective barrier between each other at the cell membrane tight junction to stop hydrogen ions leaking back. Because this is extremely hard work and the body does not want to waste energy, the main regulator for the cell membrane tight ...
Gastric acid secretion was assessed in 20 patients with kwashiorkor by means of the augmented histamine test. In 16 patients satisfactory acid secretion was demonstrated, some of them actually showing hypersecretion after histamine stimulation.
대전광역시 유성구 대학로 245 한국과학기술정보연구원TEL : 042.869.1234 서울시 동대문구 회기로 66NDSL고객센터 : 080.969.4114E-mail : [email protected] 대표자 : 한선화사업자등록번호 : 205-82-04043 ...
Galway Bay fm newsroom - The Chief Superintendent of Galway Garda Division said he has personally reviewed more than 100 recordings relating to breath tests in the division.. The review was undertaken in light of the fake breath test scandal which revealed that figures for breath tests had been inflated by up to two million across the country.. Chief Superintendent Tom Curley listened to 108 recordings which the Assistant Garda Commissioner flagged for the Galway division.. He told a meeting of the City Joint Policing Committee this week that he did not find any evidence for disciplinary or courts action.. The Chief Super said he recognised a weakness in the Dräger system for recording the presence of alcohol on someones breath back in 2014.. He began to implement a more precise system in Galway back then, prior to the scandal regarding breath tests emerging.. ...
Dipyrone contains active substance called metamizole (analgesic from the pyrazolone group). It depressess central nervous system and causes a pain relief.
Researchers from the Israel Institute of Technology have invented a breath test to check for head and neck cancers. Breath was collected from 87 subjects, some of whom were healthy, some had head o
A brief note curtecy of our old friend Flanker!! Breath tests for yachtsmen As expected, the Railways and Transport Safety Bill promised by the Government before the last election will extend the

Dose dependence of the14C-aminopyrine breath test | SpringerLinkDose dependence of the14C-aminopyrine breath test | SpringerLink

Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological ... Aminopyrine metabolism 14CO2-breath test aminopyrine demethylation dose dependent metabolism physical fitness ... Brodie, B.B., Axelrod, J.: The fate of aminopyrine (Pyramidon) in man and methods for the estimation of aminopyrine and its ... Assessment of aminopyrine metabolism in man by breath analysis after oral administration of14C-aminopyrine. Effects of ...
more infohttps://link.springer.com/article/10.1007/BF00609866

Characterization of oxyntic glands isolated from the rat gastric mucosaCharacterization of oxyntic glands isolated from the rat gastric mucosa

Using this method we studied the effect of CCK-like peptides on [14C]aminopyrine accumulation stimulated by histamine, in order ... Histamine dose-dependently stimulated the acid formation which was measured as the accumulation of [14C]aminopyrine. At 100 ... aminopyrine accumulation. Upon stimulation with a high dose of histamine the production of acid increased 5-fold over basal. ... were CCK 8 and the cholecystokinetic amphibian decapeptide cemlein reducing the maximal histamine stimulation of aminopyrine ...
more infohttp://liu.diva-portal.org/smash/record.jsf?pid=diva2:245243

Amidopyrine synonyms, amidopyrine antonyms - FreeThesaurus.comAmidopyrine synonyms, amidopyrine antonyms - FreeThesaurus.com

1 synonym for amidopyrine: aminopyrine. What are synonyms for amidopyrine? ... aminopyrine,type:2},{name:analgesic,type:4},{name:anodyne,type:4},{name:pain pill,type:4},{name: ...
more infohttp://www.freethesaurus.com/amidopyrine

Dipyrone - Biology-Online DictionaryDipyrone - Biology-Online Dictionary

It is the sodium sulfonate of aminopyrine. Because of the risk of serious adverse effects its use is justified only in serious ...
more infohttp://www.biology-online.org/bodict/index.php?title=Dipyrone&oldid=23036

Barbital | The Chopra LibraryBarbital | The Chopra Library

The physical dependence liability of guanabenz, a hypotensive agent with central noradrenergic alpha 2-agonistic activity, was investigated. 1) Guanabenz showed a potent analgesic effect nearly equipotent to morphine by the modified Haffners method, and repeated p.o. treatment resulted in the development of tolerance to the effect. 2) In the combined treatment of guanabenz with morphine or hexobarbital, it potentiated morphine analgesia and prolonged hexobarbital hypnosis in a dose dependent manner ...
more infohttp://isharonline.org/tags/barbital

AminopyrineAminopyrine

Other names: 3H-Pyrazol-3-one, 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-; Antipyrine, 4-(dimethylamino)-; (Dimethylamino)phenazone; Amidazophen; Amidazophene; Amidofebrin; Amidofen; Amidophen; Amidophenazone; Amidopyrazoline; Amidopyrin; Amidopyrine; Aminophenazon; Aminophenazone; Aminopyrin; Anafebrina; Brufaneuxol; Dereuma; Dimapyrin; Dimethylamino-analgesine; Dimethylaminoantipyrine; Dimethylaminoazophene; Dimethylaminophenyldimethylpyrazolone; Dipirin; Dipyrin; Dipyrine; Febrinina; Febron; Itamidone; Novamidon; Piramidon; Piridol; Piromidina; Polinalin; Pyradone; Pyramidon; Pyramidone; 4-(Dimethylamino)antipyrine; 4-(Dimethylamino)phenazone; 1,5-Dimethyl-2-phenyl-4-dimethylamino-3-pyrazolone; Amidazofen; Eufibron; Hyparon; Mamallet-A; Pirazon; 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone; 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one; 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazolone-5; 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone; ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=58-15-1&Units=SI

VALUE OF AMINOPYRINE*† | Annals of Internal Medicine | American College of PhysiciansVALUE OF AMINOPYRINE*† | Annals of Internal Medicine | American College of Physicians

VALUE OF AMINOPYRINE(VALUE OF AMINOPYRINE*†)(VALUE OF AMINOPYRINE*†) LEONARD CARDON, M.D., F.A.C.P.; OSCAR H. COMESS, M.D.; ... VALUE OF AMINOPYRINE(VALUE OF AMINOPYRINE*†)(VALUE OF AMINOPYRINE*†). Ann Intern Med. 1958;48:616-634. doi: 10.7326/0003-4819- ... Aminopyrine, by force of historical circumstances, has been such a discredited drug for many years.1, 2a, 3c, 4b, 5, 6, 7, 8 ... Quantitative Assessment of Hepatic Function by Breath Analysis after Oral Administration of [14C]aminopyrine Annals of Internal ...
more infohttp://annals.org/aim/article/676788/value-aminopyrine

Aminopyrine Aminophenazone AmidopyrineCAS:58-15-1 - Wuhan Carphetin Chemical Co.,LTD - ecplaza.netAminopyrine Aminophenazone AmidopyrineCAS:58-15-1 - Wuhan Carphetin Chemical Co.,LTD - ecplaza.net

MF:C13H17N3O MW:231.29 CAS:58-15-1 EINECS:200-365-8 Apperance:White fronds crystal or crystalline powder. No smell, taste slightly bitter. Product use: Antipyretic and analgesic, used for fever and headache, joint pain, neuralgia, dysmenorrhea and...
more infohttps://www.ecplaza.net/products/aminopyrine-aminophenazone-amidopyrinecas58-15-1_3872768

Effect of Compound Aminopyrine Phenacetin Tablets on kidney kidneyhealthyEffect of Compound Aminopyrine Phenacetin Tablets on kidney kidneyhealthy

... to understand the pain of a piece of adverse reactions and pharmacological toxicology Compound Aminopyrine Phenacetin Tablets ( ... Effect of Compound Aminopyrine Phenacetin Tablets on kidney. First, to understand the pain of a piece of adverse reactions and ... This compound contains aminopyrine and phenacetin have obvious adverse reactions. Taking the amino group can vomiting, rash, ... 2 aminopyrine react with food in the stomach, can form carcinogenic N-nitroso compounds, especially nitrosamines, therefore has ...
more infohttp://www.kidneyhealthy.com/patcare/2228.html

Aminopyrine breath test predicts surgical risk for patients with liver disease. - COREAminopyrine breath test predicts surgical risk for patients with liver disease. - CORE

Aminopyrine breath test predicts surgical risk for patients with liver disease. By R A Gill, M W Goodman, G R Golfus, G R ... To determine whether the [14C] aminopyrine breath test (ABT) predicts surgical risk in patients with liver disease, it was ...
more infohttps://core.ac.uk/display/3862174

Plus itPlus it

14C]aminopyrine accumulation in rabbit isolated gastric glands.. In intact gastric glands from rabbits, histamine significantly ... The following drugs were used in this study: [14C]Aminopyrine (specific activity 96.6 Ci/mmol), [3H]DTG (specific activity 35.2 ... 7). Finally, BDF 6143 up to 100 μM did not alter histamine-induced [14C]aminopyrine accumulation (n = 3; results not shown). ... 7). At this high concentration, clonidine increased [14C]aminopyrine accumulation in 2 of 4 experiments, but because of the ...
more infohttp://jpet.aspetjournals.org/content/285/1/170

Compound Report CardCompound Report Card

ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:, Synonyms:AMINOPYRINE , AMINOPHENAZONE CYCLAMATE , AMINOPHENAZONE , ... AMINOPYRINE. ChEMBL Synonyms AMINOPYRINE , AMINOPHENAZONE CYCLAMATE , AMINOPHENAZONE , AMIDOPYRINE. Max Phase. 4 (Approved). ...
more infohttps://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL288470

DipyroneDipyrone

Aminopyrine sodium sulfonate; Analgin; Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt; (Antipyrinylmethylamino) ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=68-89-3&Units=SI

Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands.Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands.

Background 14C-aminopyrine accumulation (bg) is also shown. b) Accumulation of 14C-aminopyrine in gastric glands pretreated ... Accumulation of 14C-labeled aminopyrine in db-cAMP-stimulated gastric glands. All values are expressed as percent of a value ... Accumulation of 14C-labeled aminopyrine in histamine-stimulated gastric glands. All values are expressed as percent of the ... Aminopyrine / metabolism. Arginine / pharmacology. Bucladesine / metabolism. Carbon Radioisotopes / metabolism. Enzyme ...
more infohttp://www.biomedsearch.com/nih/Nitric-oxide-endogenous-inhibitor-gastric/15298720.html

Food and Drug RegulationsFood and Drug Regulations

C.01.131 - Aminopyrine and Dipyrone *C.01.134 - Coated Potassium Salts *C.01.401 - Antibiotics ...
more infohttp://laws.justice.gc.ca/eng/regulations/C.R.C.,_c._870/page-121.html

Simple Ion Transfer at Liquid|Liquid InterfacesSimple Ion Transfer at Liquid|Liquid Interfaces

... aminopyrine, 4-aminoantipyrine [244]; minocycline [288]; Tl+ [130, 260], Ag+, H+ [130]; oxybuprocaine, prilocaine, mepivacaine ...
more infohttps://www.hindawi.com/journals/ijelc/2012/462197/

Naturopathic Physicians RegulationNaturopathic Physicians Regulation

Aminopyrine and its derivatives. Cyclosporine. Amprenavir and its salts and derivatives. Cytarabine and its salts. ...
more infohttp://www.bclaws.ca/EPLibraries/bclaws_new/document/ID/freeside/282_2008

Acute hemolytic anemia induced by a pyrazolonic drug in a child with glucose-6-phosphate dehydrogenase deficiency.Acute hemolytic anemia induced by a pyrazolonic drug in a child with glucose-6-phosphate dehydrogenase deficiency.

Aminopyrine / analogs & derivatives*. Anemia, Hemolytic / chemically induced*. Child, Preschool. Dipyrone / adverse effects*. ...
more infohttp://www.biomedsearch.com/nih/Acute-hemolytic-anemia-induced-by/6438997.html

BR-4935
     Summary Report | CureHunterBR-4935 Summary Report | CureHunter

cardiotonic; a non-adenosine analog adenosine1-receptor agonist with a substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyrine ...
more infohttp://www.curehunter.com/public/keywordSummaryC550241-BR-4935.do

Glycocholic Acid
     Summary Report | CureHunterGlycocholic Acid Summary Report | CureHunter

Aminopyrine (Aminophenazone) 5. Sodium 6. Chenodeoxycholic Acid (Chenix) 7. Alanine Transaminase (SGPT) ...
more infohttp://www.curehunter.com/public/keywordSummaryD006000-Glycocholic-Acid.do

CiNii Articles - KARIYA KimioCiNii Articles - KARIYA Kimio

Comparison of Age-Related Peripheral Nerve Changes in Mice Housed in Either Plastic Cages with Sawdust-Covered Solid Flooring or Wire-Mesh-Floor Cages (2000 ...
more infohttps://ci.nii.ac.jp/author?q=KARIYA+Kimio

Aspirin - NO.30372Aspirin - NO.30372

Aminopyrine Aminopyrine CAS NO. 8015-18-7 Appearance White crystal powder Molecular Formula C13H17N3O•C8H12N2O3 Molecular ... ... It is the sodium sulfonate of AMINOPYRINE. ... Amoxicillin Amoxicillin Quality standard: BP CP USP Content: 90% CAS No: 61336- ...
more infohttp://www.trader-china.com/Health-Beauty/Medicine-Health/Drugs-Medications/aspirin-l30372.html

Caco-2 Permeability and Solubility Parameter (HSP)Caco-2 Permeability and Solubility Parameter (HSP)

Aminopyrine. 58-94-6. Chlorothiazide. 13523-86-9. Pindolol. 87-08-1. Penicillin V. 298-46-4. Carbamazepine. ...
more infohttp://pirika.com/NewHP/PirikaE2/Caco-2.html