A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.
A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.
Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Hydrochloric acid present in GASTRIC JUICE.
An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
A barbiturate that is effective as a hypnotic and sedative.
A group of compounds that contain a bivalent O-O group, i.e., the oxygen atoms are univalent. They can either be inorganic or organic in nature. Such compounds release atomic (nascent) oxygen readily. Thus they are strong oxidizing agents and fire hazards when in contact with combustible materials, especially under high-temperature conditions. The chief industrial uses of peroxides are as oxidizing agents, bleaching agents, and initiators of polymerization. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Compounds with a five-membered heterocyclic ring with two nitrogens and a keto OXYGEN. Some are inhibitors of TNF-ALPHA production.
A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity.
A hypnotic and sedative. Its use has been largely superseded by other drugs.
A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
The removing of alkyl groups from a compound. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.
Any tests done on exhaled air.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)
Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.
Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
A publication issued at stated, more or less regular, intervals.
Individuals licensed to practice medicine.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Painful menstruation.
Any technique by which an unknown color is evaluated in terms of standard colors. The technique may be visual, photoelectric, or indirect by means of spectrophotometry. It is used in chemistry and physics. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
A country spanning from central Asia to the Pacific Ocean.
The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
A metabolite of AMINOPYRINE with analgesic and anti-inflammatory properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates LIVER MICROSOMES and is also used to measure extracellular water.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Receptors of CLONIDINE and other IMIDAZOLINES. Activity of the ligands was earlier attributed to ADRENERGIC ALPHA-2 RECEPTORS. Endogenous ligands include AGMATINE, imidazoleacetic acid ribotide, and harman.
The superior portion of the body of the stomach above the level of the cardiac notch.
Compounds based on reduced IMIDAZOLES containing a single double bond.
A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.
Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat. (1/181)

Despite its hepatotoxic potential, cyclosporine A (CsA) has been reported to positively influence compensatory liver growth. To probe the physiological consequences of CsA on the recovery of liver function, studies were initiated in the 2/3 partially hepatectomized (PHx) rat, taking the recovery of cytochromes P-450-dependent drug metabolism as primary outcome. CsA was administered at a dose of 3. 33 mg/kg/day for 10 days. Drug metabolism was evaluated by the recovery of 14CO2 after administration of isotopically labeled model drugs and by studying the expression of the P-450 transcripts involved in their biotransformation before and 24 to 96 h after PHx. Before PHx, neither the steady-state mRNA nor the in vivo disposition of caffeine (CYP1A2), erythromycin (CYP3A2 and 3A1), or aminopyrine (CYP2B1 and 2C11) were influenced by CsA. Studies 24 h after PHx revealed a 29 to 39% reduction in the elimination of [14C]aminopyrine and [14C]erythromycin, which was unaffected by CsA. Their metabolism at 48 to 96 h after PHx also remained unaffected by CsA. By contrast, postPHx, [14C]caffeine elimination decreased to a level closely proportional to the loss in liver mass. In addition, CsA accelerated the recovery and/or prevented the decrease of caffeine elimination 24 h after PHx but not at later time points, indicating an early, but unsustained, beneficial effect of CsA on the recovery of CYP1A2-mediated activities. These data show that at the critical time of greatest loss in liver mass, CsA has only a selective influence on the biotransformation of cytochrome P-450 protein-dependent activities and that its effect on the regeneration process does not translate into an overall accelerated recovery of the hepatic drug-metabolizing function.  (+info)

L-365,260 inhibits in vitro acid secretion by interacting with a PKA pathway. (2/181)

The aim of this study was to analyse the antisecretory mechanism of L-365,260 in vitro in isolated rabbit gastric glands. We showed that compound L-365,260, described as a non-peptide specific competitive CCK-B receptor antagonist, was able to dose-dependently inhibit [14C]-aminopyrine accumulation induced by histamine (10(-4) M), carbachol (5x10(-5) M), 3-isobutyl-1-methyl-xanthine (IBMX) (5x10(-6) M) and forskolin (5x10(-7) M) with similar IC50 values respectively of 1.1+/-0.6x10(-7) M, 1.9+/-1.2x10(-7) M, 4.2+/-2.0x10(-7) M and 4.0+/-2.8x10(-7) M. We showed that L-365,260 acted beyond receptor activation and production of intracellular second messengers and that it had no action on the H+/K+ -ATPase. We found that L-365,260 inhibited cyclic AMP-induced [14C]-aminopyrine accumulation in digitonin-permeabilized rabbit gastric glands, suggesting that this compound acted, at least in part, as an inhibitor of the cyclic AMP-dependent protein kinase (PKA) pathway.  (+info)

Demethylation capacity of human fetal adrenal mitochondrial cytochrome P-450 in vitro. (3/181)

AIM: To explore the capacity and characteristics of adrenal mitochondria to metabolize xenobiotics in vitro in human fetus. METHODS: Subcellular fractions of fetal adrenal were prepared by differential centrifugation. Mitochondrial P-450 system was proved by spectral analyses and SDS-PAGE. The formaldehyde formation contents were measured with Nash reagent. RESULTS: The erythromycin N-demethylation linearly increased in the protein concentration (1-4 mg)- and incubation time (10-30 min)-dependent manners. A typical concentration-effect relationship appeared with erythromycin 0.067-1 mmol.L-1 and a positive correlation (r = 0.641, P < 0.05) existed between erythromycin N-demethylation and gestation months. The N-demethylation values (nmol.s-1/g protein) of erythromycin (2.7 +/- 0.8), benzfetamine (1.1 +/- 0.5), and aminophenazone (0.9 +/- 0.4) in mitochondria were 89% (P > 0.05), 162% (P < 0.01), and 62% (P < 0.01), respectively, of those in microsomes. There was correlation between mitochondria and microsomes in the N-demethylation of erythromycin (r = 0.708, P < 0.05) and benzfetamine (r = 0.707, P < 0.05). Troleandomycin stimulated erythromycin N-demethylation in adrenal mitochondria as well as in adrenal and liver microsomes in vitro. CONCLUSION: Fetal adrenal mitochondria, with multiple P-450 isoforms and greater capacity of demethylation, play a role in drug-metabolism during fetal development.  (+info)

Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. (4/181)

Stimulation of the gastric parietal cell results in a massive redistribution of H+-K+-ATPase from cytoplasmic tubulovesicles to the apical plasma membrane. Previous studies have implicated the small GTPase rab11 in this process. Using matrix-assisted laser desorption mass spectrometry, we confirmed that rab11 is associated with H+-K+-ATPase-enriched gastric microsomes. A stoichiometry of one rab11 per six copies of H+-K+-ATPase was estimated. Furthermore, rab11 exists in at least three forms on rabbit gastric microsomes: the two most prominent resemble rab11a, whereas the third resembles rab11b. Using an adenoviral expression system, we expressed the dominant negative mutant rab11a N124I in primary cultures of rabbit parietal cells under the control of the tetracycline transactivator protein (tTA). The mutant was well expressed with a distribution similar to that of the H+-K+-ATPase. Stimulation of these cultures with histamine and IBMX was assessed by measuring the aminopyrine (AP) uptake relative to resting cells (AP index). In experiments on six culture preparations, stimulated uninfected cells gave an AP index of 10.0 +/- 2.9, whereas parallel cultures expressing rab11a N124I were poorly responsive to stimulation, with a mean AP index of 3.2 +/- 0. 9. Control cultures expressing tTA alone or tTA plus actin responded equally well to stimulation, giving AP index values of 9.0 +/- 3.1 and 9.6 +/- 0.9, respectively. Thus inhibition by rab11a N124I is not simply due to adenoviral infection. The AP uptake data were confirmed by immunocytochemistry. In uninfected cells, H+-K+-ATPase demonstrated a broad cytoplasmic distribution, but it was cleared from the cytoplasm and associated with apically derived membranes on stimulation. In cells expressing rab11a N124I, H+-K+-ATPase maintained its resting localization on stimulation. Furthermore, this effect could be alleviated by culturing infected cells in the presence of tetracycline, which prevents expression of the mutant rab11. We therefore conclude that rab11a is the prominent GTPase associated with gastric microsomes and that it plays a role in parietal cell activation.  (+info)

Responsiveness of beta-escin-permeabilized rabbit gastric gland model: effects of functional peptide fragments. (5/181)

We established a beta-escin-permeabilized gland model with the use of rabbit isolated gastric glands. The glands retained an ability to secrete acid, monitored by [14C]aminopyrine accumulation, in response to cAMP, forskolin, and histamine. These responses were all inhibited by cAMP-dependent protein kinase inhibitory peptide. Myosin light-chain kinase inhibitory peptide also suppressed aminopyrine accumulation, whereas the inhibitory peptide of protein kinase C or that of calmodulin kinase II was without effect. Guanosine-5'-O-(3-thiotriphosphate) (GTPgammaS) abolished cAMP-stimulated acid secretion concomitantly, interfering with the redistribution of H+-K+-ATPase from tubulovesicles to the apical membrane. To identify the targets of GTPgammaS, effects of peptide fragments of certain GTP-binding proteins were examined. Although none of the peptides related to Rab proteins showed any effect, the inhibitory peptide of Arf protein inhibited cAMP-stimulated secretion. These results demonstrate that our new model, the beta-escin-permeabilized gland, allows the introduction of relatively large molecules, e.g., peptides, into the cell, and will be quite useful for analyzing signal transduction of parietal cell function.  (+info)

Regulation and function of p38 protein kinase in isolated canine gastric parietal cells. (6/181)

We examined the regulation and functional role of p38 kinase in gastric acid secretion. p38 kinase was immunoprecipitated from cell lysates of highly purified gastric parietal cells in primary culture, and its activity was quantitated by in vitro kinase assay. Carbachol effects were dose- and time-dependent, with a maximal 10-fold stimulatory effect detected after 30 min of incubation. SB-203580, a highly selective inhibitor of p38 kinase, blocked carbachol induction of p38 kinase activity, with maximal inhibition at 10 microM. Stimulation by carbachol was unaffected by preincubation of parietal cells with the intracellular Ca(2+) chelator BAPTA-AM, but incubation of cells in Ca(2+)-free medium led to a 50% inhibition of carbachol induction of p38 kinase activity. Because some of the effects of carbachol are mediated by the small GTP-binding protein Rho, we examined the role of Rho in carbachol induction of p38 kinase activity. We tested the effect of exoenzyme C3 from Clostridium botulinum (C3), a toxin known to ADP-ribosylate and specifically inactivate Rho. C3 led to complete ADP-ribosylation of Rho, and it inhibited carbachol induction of p38 kinase by 50%. We then tested the effect of SB-203580 and C3 on carbachol-stimulated uptake of [(14)C]aminopyrine (AP). Inhibition of p38 kinase by SB-203580 led to a dose-dependent increase in AP uptake induced by carbachol, with maximal (threefold) effect at 10 microM SB-203580. Similarly, preincubation of parietal cells with C3 led to a twofold increase in AP uptake induced by carbachol. Thus carbachol induces a cascade of events in parietal cells that results in activation of p38 kinase through signaling pathways that are at least in part dependent on Rho activation and on the presence of extracellular Ca(2+). p38 kinase appears to inhibit gastric acid secretion.  (+info)

Tryptophan operon read-through. Isolation and characterization of an abnormally long tryptophan synthetase alpha subunit from a frame-shift mutant of Escherichia coli. (7/181)

A new mutant strain of Escherichia coli, strain ICR-47, contains a frame-shift mutation in the trpA gene, the gene most distal to the operator in the trp operon. Mapping experiments indicate that the lesion is located at a site within 10 to 15% of the end of this gene. The mutation results in "out-of-phase" translation of the distal portion of the trp mRNA; normal translational termination signal(s) are not encountered and a trpA gene product longer than the wild type protein is produced. As with the other enzymes produced from this operon, the in vivo level of the altered protein (the alpha subunit of the tryptophan synthetase enzyme complex) is controlled by exogenous L-tryptophan. The altered alpha subunit from the strain ICR-47 has been isolated and characterized. Molecular weight estimations indicate a molecular weight of approximately 37,000, an increase beyond the wild type enzyme corresponding to an additional 50 to 70 amino acid residues. The protein has a new COOH-terminal amino acid sequence. Results of preliminary hybridization experiments suggest that the ICR-47 mRNA, which is necessarily longer than that needed to code for wild type enzyme, is not detectably different in size from wild type mRNA. The enzymatic properties of the ICR-47 alpha subunit indicates a greatly reduced ability of the mutant subunit to combine functionally with wild type beta2 subunit, the second protein component in the tryptophan synthetase enzyme complex. In contrast, only 40 to 50% of the intrinsic enzymatic activity of the alpha subunit is lost.  (+info)

A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol. (8/181)

Acid secretion in isolated rabbit gastric glands was monitored by the accumulation of [(14)C]aminopyrine. Stimulation of the glands with carbachol synergistically augmented the response to dibutyryl cAMP. The augmentation persisted even after carbachol was washed out and was resistant to chelated extracellular Ca(2+) and to inhibitors of either protein kinase C or calmodulin kinase II. Cytochalasin D at 10 microM preferentially blocked the secretory effect of carbachol and its synergism with cAMP, whereas it had no effect on histamine- or cAMP-stimulated acid secretion within 15 min. Cytochalasin D inhibited the carbachol-stimulated intracellular Ca(2+) concentration ([Ca(2+)](i)) increase due to release from the Ca(2+) store. Treatment of the glands with cytochalasin D redistributed type 3 inositol 1,4,5-trisphosphate receptor (the major subtype in the parietal cell) from the fraction containing membranes of large size to the microsomal fraction, suggesting a dissociation of the store from the plasma membrane. These findings suggest that intracellular Ca(2+) release by cholinergic stimulation is critical for determining synergism with cAMP in parietal cell activation and that functional coupling between the Ca(2+) store and the receptor is maintained by actin microfilaments.  (+info)

Synonyms for amidopyrine in Free Thesaurus. Antonyms for amidopyrine. 1 synonym for amidopyrine: aminopyrine. What are synonyms for amidopyrine?
Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. Nine volunteers were given14...
The design of methods useful for the preparation of viable glands and cells from the gastric mucosa allowed detailed studies on the mechanisms that regulate gastric acid secretion. The preparation of rabbit gastric glands was the first suitable method to be used and a number of important scientific contributions have been accomplished with this method. Using this method we studied the effect of CCK-like peptides on [14C]aminopyrine accumulation stimulated by histamine, in order to fmd out whether such peptides can inhibit the production of acid in the parietal cell. We also developed a method for the study of viable rat gastric glands that allowed comparative studies in the rat species.. In rabbit gastric glands CCK-like pep tides inhibited histamine stimulated acid formation whereas gastrin peptides were ineffective. The most potent and efficacious peptides were CCK 8 and the cholecystokinetic amphibian decapeptide cemlein reducing the maximal histamine stimulation of aminopyrine accumulation ...
Aminophenazone (or aminopyrine, amidopyrine, Piramidon) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests. It is also used in measuring the total body water in the human body system. Production and use have been banned in France, Thailand and India. Symptoms of exposure to this compound include: allergic reactions strong spasmolytic effect on smooth muscle of peripheral blood vessels irritability palsy copious sweating dilated pupils sharp drop then rise in body temperature dysuria dyspnea anxiety tenesmus[disambiguation needed] urinary frequency intermittent fever fatty infiltration of the liver heart muscle degeneration death due to circulatory failure following cardiovascular collapse Agranulocytosis often occurs. Ingestion may cause central nervous system stimulation, vomiting, ...
Dietary habits are often considered as a pathogenic factor for fatty liver. The impact of dietary intake and steatosis on drug metabolism remains poorly investigated. Our aim was to assess the effect of dietary intake on in vivo cytochrome P450 (CYP) activities in eleven patients with abnormal liver function tests potentially due to fatty liver and associated with a high-sugar diet. Liver function tests, liver volume, aminopyrine breath test (ABT) and chlorzoxazone (CZ) pharmacokinetics (area under the curve, AUC) which are known to reflect CYP2E1 activity were evaluated before and after 2 months restriction of dietary sugar intake. Features at inclusion were an increased BMI (30.3 (SD 3.2) kg/m2), high hepatic volume (1.96 (SD 0.48) litres), hyperechogenic liver parenchyma, elevated liver enzyme activities (alanine aminotransferase (EC 2.6.1.2) 58.6 (SD 17.4) IU/1 with alanine aminotransferase: aspartate aminotransferase (EC 2.6.1.1) ratio , 1), together with a normal ABT value (0.68 (SD 0.21)% ...
Modern medical science has made such tremendous strides in the field of therapeutics that many older drugs, especially if potentially productive of untoward and dangerous side-effects, have been discredited and have fallen into disuse. Admittedly, many such drugs have marked therapeutic value and are deserving of further investigation and clinical trial before they are completely discarded.. Aminopyrine, by force of historical circumstances, has been such a discredited drug for many years.1, 2a, 3c, 4b, 5, 6, 7, 8 The danger of agranulocytosis resulting from its use is real and well established, but undoubtedly has been overemphasized.1, 2a, 4b, 5, 6, ...
MF:C13H17N3O MW:231.29 CAS:58-15-1 EINECS:200-365-8 Apperance:White fronds crystal or crystalline powder. No smell, taste slightly bitter. Product use: Antipyretic and analgesic, used for fever and headache, joint pain, neuralgia, dysmenorrhea and...
With that encouragement Axelrod quickly showed that amphetamine was rapidly metabolized in rabbit liver slices. He went on to define the co-factor requirements for the reaction finding that NADPH was required; similar to observations of Bert LaDu in his studies on aminopyrine demethylation9.Axelrod then determined the sub-cellular location of the activity by using methods developed by Hogeboom and Schneider10. This newly defined microsomal oxidizing system was soon shown to be responsible for the metabolism of a wide variety of drugs and other chemicals.. Ref: 1V.R.Potter and C.A.Elvehjem, J.Biol. Chem. ,114:495-504 (1936) 2A.Claude, Cold String Harbor Symposium Quant.Biol.,9:263-270 (1941)3 W.C.Schneider,J.Biol.Chem. 165:585-593 (1949) 4E.C.Miller and J.A.Miller, Cancer Res. 7:468-480 (1947)5 E.S.Stevenson, K. Dobriner, and C.P.Rhoads, Cancer Research 2:160-167 (1942)6 G.C.Mueller and J.A.Miller, J.Biol.. Chem. 176:535-544 (1948) 7G.C.Mueller and J.A. Miller, J.Biol. Chem. ,180:1125-1236 ...
The involvement of a thromboxane (TX) A2-like substance in the decrease of mucosal blood flow (MBF) and occurrence of gastric erosions in rats under water-immersion stress was examined. MBF was estimated by aminopyrine clearance. Stress increased acid output without a parallel increase in MBF and caused erosions. OKY-046, an inhibitor of TXA2 synthesis, and ONO-11120, an antagonist of TXA2 receptors, increased MBF during stress in parallel with an increase in acid output, and erosions did not form. In another experiment, the effects of a TXA2-like substance on MBF during vagal stimulation were examined. Although vagal stimulation alone increased acid output, there were no erosions in the stomach, probably because MBF was increased in parallel with acid output. Intra-arterial administration of a TXA2-like substance formed by the metabolism of arachidonic acid in the blood reduced MBF during vagal stimulation. Intra-arterial administration of ONO-11113, an agonist of TXA2 receptors, also reduced ...
Novodone information about active ingredients, pharmaceutical forms and doses by AGIPS Farmaceutici, Novodone indications, usages and related health products lists
BR-4935: cardiotonic; a non-adenosine analog adenosine1-receptor agonist with a substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyrine
A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has Risk of Agranulocytosis. A Breath Test with 13C-labeled aminopyrine has been used as a non-invasive measure of Cytochrome P-450 metabolic activity in LIVER FUNCTION TESTS ...
The effect of ethanol on N-demethylation of aminopyrine in rat liver slices and in the microsomal fraction and on microsomal hydroxylation of pentobarbital and aniline was studied. With liver slices N-demethylation of aminopyrine was stimulated by 35-40% at low ethanol concentrations (2mm), whereas no stimulation occurred at high concentrations (100mm). With the liver microsomal fraction, an inhibitory effect was observed only at high ethanol concentrations (100mm). This was also observed with the other drugs studied. In agreement with these results, only at a high concentration did ethanol interfere with the binding of drug substrates to cytochrome P-450. Further, as previously reported, ethanol produced a reverse type I spectral change when added to the liver microsomal fraction. Evidence that this spectral change is due to removal of substrate, endogenously bound to cytochrome P-450, is reported. A dual effect of ethanol is assumed to explain the present findings; in liver slices, at a low ...
Comparative studies of in vitro drug metabolism by hepatic and extrahepatic tissues have been complicated by the use of a single experimental tissue, few animal species, and variable experimental conditions. In an attempt to minimize these complications, liver, lung and kidney from rat, mouse, rabbit, hamster, and guinea pig were assayed for standard microsomal and soluble fraction enzymes involved in drug biotransformation. For all species, liver was the most active organ. Kidney and lung activities were usually 15%-40% of those found in liver, with kidney slightly more active than lung. No single species demonstrated total superiority in its drug-metabolizing ability, although hamster showed a large number of instances of greatest activity. The rat was a surprisingly poor representative of drug-metabolizing ability; it was superior to the other four species in less than 25% of the instances studied. All species appeared to N-demethylate aminopyrine equally except for high pulmonary and nearly ...
While the governance of algorithms is of growing societal concern, the energy sector has been slow to engage with this issue. We argue that there are at least three systemic concerns to the design and operation of algorithms in the new, digital energy era. Namely, reliance on algorithms can bi...
The uptake of [14C]-aminopyrine by rabbit gastric epithelial cells was used as an indirect assay for acid secretion from parietal cells. Campylobacter pylori strains, isolated from the stomachs of 3 patients with chronic gastritis, duodenal ulcer, and near-normal mucosa, respectively, inhibited acid …
Chemicals - Coatings China, Formic Acid Rubber Pulp Disinfest, Uses: 1. Pharmaceutical industry: Caffeine, Enzimes, Aminopyrine, Vitamin B1 2. Pesticide industry: Triazolone, Disinfes...
Maintaining healthy cells is the key to experimental success and reproducible research results. To give you confidence in the health of your cells every step of the way, weve highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. No matter how you are using your cells, you can count on these products to help keep them healthy.. ...
The effect of a 20-day administration of aminopyrine (600 mg kg-1) as well as two metabolites of aminopyrine, 4-aminoantipyrine (525 mg kg-1) and 4-acetamidoantipyrine (635 mg kg-1), on several hepatic, kidney and serum enzyme activities were investigated. In the aminopyrine-treated group, a pronounced induction of gamma-glutamyl transpeptidase was shown in the whole homogenate as compared to that in the hepatic microsomes. Serum gamma-glutamyl transpeptidase activity was also increased by administration of aminopyrine or 4-aminoantipyrine. No change in gamma-glutamyl transpeptidase activity was observed in kidney and hepatic cytosolic fractions. In all cases, 4-acetamidoantipyrine treatment showed no significant change in the enzyme activities tested. Under the same experimental condition, the amounts of cytochrome P-450 and b5, the activities of aminopyrine N-demethylase, aniline hydroxylase and carboxylesterase of liver microsomes were all induced in the aminopyrine- and ...
The gastric autoantigens. The two autoantigens targeted by autoantibodies are components unique to the gastric parietal cell in the. Figure 1 The gastric parietal cell antibody detected by immunofluorescence and illustrated here on murine gastric mucosa reacts with the cytoplasm of gastric parietal cells. Characteristic of the Immunofluorescence reaction is the denser staining of the newly formed cells at the base of the mucosa (bottom left) and lighter staining of the mature cells towards the top of the mucosa. Experimental evidence suggests that the autoantigen in the parietal cell is the enzyme H+,K*-ATPase which is involved in production of acid secreted into the gastric juice.. body of the stomach. The autoantigen with which GPCA reacts is the enzyme H+,K+-adenosine triphosphatase (H+,K+-ATPase) which is cell-specific but not species-specific, indicating the importance of the physiologic role of the molecule in the gastric parietal cell. The second autoantigen is a secreted product of the ...
We previously reported that both carbachol and epidermal growth factor (EGF) are potent inducers of the extracellular signal-regulated protein kinases (ERKs) in isolated gastric canine parietal cells and that induction of these kinases leads to acute inhibitory and chronic stimulatory effects on gastric acid secretion. In this study we investigated the molecular mechanisms responsible for these effects. Both carbachol (100 microM) and EGF (10 nM) induced Ras activation. The role of Ras in ERK2 induction was examined by transfecting parietal cells with a vector expressing hemoagglutinin (HA)-tagged ERK2 (HA-ERK2) together with a dominantly expressed mutant (inactive) ras gene. HA-ERK2 activity was quantitated by in-gel kinase assays. Dominant negative Ras reduced carbachol induction of HA-ERK2 activity by 60% and completely inhibited the stimulatory effect of EGF. Since Ras activation requires the assembly of a multiprotein complex, we examined the effect of carbachol and EGF on tyrosyl ...
Semantic Scholar extracted view of [The blood gastrin curve after histamine stimulation and a protein meal in common diseases of the digestive tract]. by Francesco Di Mario et al.
A new cytochrome P-450 isozyme (Mr = 52,000) was purified to apparent electrophoretic homogeneity from hepatic microsomes of mice treated with acetone and its biochemical, spectral, and immunological properties characterized. Several criteria indicated that the purified cytochrome was distinct from the known mouse P-450 isozymes. The absolute spectrum of its oxidized form indicated that it was in the high spin state. In a reconstituted system, it showed low catalytic activities towards 7-ethoxycoumarin, aminopyrine, and coumarin, whereas it catalyzed the oxidation of aniline, acetone, dimethylnitrosamine with high turnover number. The mouse enzyme was immunoreactive with polyclonal antibodies against rat P-450IIE1 and exhibited an NH2-terminal aminoacid sequence with a high homology to that of rat-P-450IIE1. Based upon the above catalytic, spectral, immunological and structural properties, the purified mouse P-450 appears to be the ortholog of previously described P-450IIE1(s) of other species ...
Serum triglycerides are hydrolyzed to glycerol and free fatty acids by lipase. In the presence of ATP and glycerol kinase (GK), the glycerol is converted to glycerol-1-phosphate. The glycerol-1-phosphate is then oxidized by glycerol phosphate oxidase (GPO) to yield hydrogen peroxide. The condensation of hydrogen peroxide with 4-chlorophenol and 4-aminophenazone (4-AA) in the presence of peroxidase (POD) produces a red colored quinonimine dye which absorbs at, or near 500nm. The intensity of the colored complex formed is directly proportional to the triglycerides concentration of the sample ...
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The Food and Drug Administration (FDA) advises the public against the purchase and use of the following unregistered drug products: 1. Compound Aminophenazone and Barbital Injection 2mL 2. Calcium Gluconate […]
A stylized view of a parietal cell. Parietal cells are found in the proximal portions of the gastric glands of the stomach and secrete HCl and intrinsic factor. - Stock Image F002/0341
Looking for online definition of proper gastric gland in the Medical Dictionary? proper gastric gland explanation free. What is proper gastric gland? Meaning of proper gastric gland medical term. What does proper gastric gland mean?
Gastric gland: false-colour scanning electron micrograph (SEM) of the mucous membrane lining the stomach, showing the shadowy entrances to a number of gastric glands. The glands secrete gastric juice (hydrochloric acid & the enzyme pepsin) and a protective mucous, derived from the simple, columnar cells (moss-like) that comprise the mucosa. Gastric glands are formed by simple invagination or tubular ingrowth of this mucosa into the underlying layer of tissue, the lamina propria. Magnification: x300 at 6x7cm size. - Stock Image P510/0042
This is probably a long-awaited update, but I assure you that this is not the last change prepared by us for the next 3 months. Let us know if everything with the new limit works as intended. Cheers ...
EUnetHTA recently started a new Collaborative Assessment on a Medical Device for rectum spacers for prostate cancer radiotherapy.. To find out about participation, please read more here.. Input submissions will be received through EOB, Friday 5th July.. ...
class=kwd-title>Keywords: von Willebrand Disease Congenital Heart Defects Children Hemorrhage Acquired Copyright notice and Disclaimer The publishers final edited version of this article is available at Haemophilia Acquired von Willebrand Syndrome (AVWS) is a bleeding disorder resulting from an acquired deficiency or dysfunction of von Willebrand factor (VWF). stress-induced increase in VWF proteolysis [2]. Diagnosing AVWS can be challenging. Amidopyrine Laboratory assessment needs documentation of the abnormality in the patients VWF. Nevertheless many pre-analytical and individual factors make a difference the sensitivity from the tests useful for diagnosing the problem. Moreover Amidopyrine the variation in assay thresholds and techniques useful for interpreting test outcomes increases the complexity of diagnosing AVWS. In addition due to the rarity of the problem as well as the challenges mixed up in laboratory assessment a higher degree of medical suspicion is necessary by healthcare ...
Abstract: Metabolism of aminopyrine, sodium benzoate and toxicity of cyclophosphamide were studied in 185 male rats under conditions of various content of vitamin B1 in the animals. Deficiency of thiamin led to an increase in excretion of 4-aminoantipyrine and especially of its acetylated derivative. After administration of thiamin metabolism of aminopyrine was not distinctly altered, while thiamin diphosphate inhibited the drug biotransformation. In deficiency of vitamin B1 transformation of benzoic acid into hippuric acid was inhibited but formation of glucuronides was elevated. Administration of thiamin or thiamin diphosphate stimulated the benzoic acid conjugation and inhibited the glucuronides formation. Deficiency of vitamin B1 accelerated the cyclophosphamide toxicity. Preadministration of thiamin and especially of thiamin diphosphate decreased the toxic effect of cyclophosphamide ...
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Medical information for Dipyrone on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Hepatic Dose.
How does IPL work for acne?. There are three forms of IPL therapy for acne - LHE Therapy, Blue-Light Therapy and IPL with medication. The choice will depend on what results youre looking for and what your dermatologist suggests as the most effective for your individual acne spots. LHE therapy uses both heat and light as the source to treat acne. The FDA has actually approved one IPL treatment that involves green light waves and heat. This form of IPL is meant to treat mild to moderate acne and more than likely, over a period of time. The whole process has been known to reduce the size of oil glands and kill the dirt bacteria in pores that create acne.. Blue-Light therapy is similar to LHE minus the UV radiation. It only makes sense that less UV radiation equals less damage on your skin. This form of IPL will have the same effect on killing the dirt bacteria but with less side effects than the LHE therapy. According to Robin McClain, who is a registered nurse practitioner from the University of ...
The aim of this study was to investigate the possible effects of sulphite oxidase (SOX, E.C. 1.8.3.1) deficiency on xenobiotic metabolism. For this purpose, SOX deficiency was produced in rats by the administration of a low molybdenum diet with concurrent addition of 200 ppm tungsten to their drinking water. First, hepatic SOX activity in deficient groups was measured to confirm SOX deficiency. Then, aminopyrine N-demethylase, aniline 4-hydroxylase, aromatase, caffeine N-demethylase, cytochrome b5 reductase, erythromycin N-demethylase, ethoxyresorufin O-deethylase, glutathione S-transferase, N-nitrosodimethylamine N-demethylase and penthoxyresorufin O-deethylase activities were determined to follow changes in the activity of drug metabolizing enzymes in SOX-deficient rats. Our results clearly demonstrated that SOX deficiency significantly elevated A4H, caffeine N-demethylase, erythromycin N-demethylase and N-nitrosodimethylamine N-demethylase activities while decreasing ethoxyresorufin ...
During incubation of antipyrine, but not amidopyrine, 4-aminoantipyrine and 4-leucylaminoantipyrine, with rat liver microsomaland cytosol fractions in the presence of NADPH-generating system a reactive metabolite, which binds with glutathione is form
Home » Dipyrone. Dipyrone (Science: chemical) ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1h-pyrazol-4-yl)methylamino)methanesulfonic acid. A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of aminopyrine. Because of the risk of serious adverse effects its use is justified only in serious situations where no alternative is available or suitable. Pharmacological action: non-steroidal anti-inflammatory agents. chemical name: Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-, sodium salt ...
TY - JOUR. T1 - Ultrastructural and morphometric features of the acetylcholine innervation in adult rat parietal cortex. T2 - An electron microscopic study in serial sections. AU - Umbriaco, Denis. AU - Watkins, Kenneth C.. AU - Descarries, Laurent. AU - Cozzari, Costantino. AU - Hartman, Boyd K. PY - 1994/10/15. Y1 - 1994/10/15. N2 - This study was aimed at characterizing the ultrastructural morphology of the normal acetylcholine (ACh) innervation in adult rat parietal cortex. After immunostaining with a monoclonal antibody against purified rat brain choline acetyltransferase (ChAT), more than 100 immunoreactive axonal varicosities (terminals) from each layer of the Par 1 area were photographed and examined in serial thin sections across their entire volume. These varicosities were relatively small, averaging 0.6 μm in diameter, 1.6 μM2 in surface, and 0.12 μM3 in volume. In every layer, a relatively low proportion exhibited a synaptic membrane differentiation (10% in layer I, 14% in II-III, ...
The Surfer on Acid is most often consumed in shot form. This variation is a long drink, made extra-refreshing with coconut water.
The acid-secretingoxyntic cell, or parietal cell, I is the main cell type in the gastric gland. Chief , cells pepsinogen-secretingcells , mucus cells, s and
the secretion of HCl and digestive enzymes by the gastric glands of the stomach.. contractions of the muscular layer of the stomach wall to increase mixing of the stomach contents. ...
Gentaur molecular products has all kinds of products like :search , Nacala \ Aniline \ 02915-25 for more molecular products just contact us
TY - JOUR. T1 - Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients with or without microcytosis. AU - Chiang, Chun Pin. AU - Yu-Fong Chang, Julia. AU - Wang, Yi Ping. AU - Wu, Yang Che. AU - Wu, Yu Hsueh. AU - Sun, Andy. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background/Purpose: Microcytosis is defined as having mean corpuscular volume (MCV) , 80 fL. This study evaluated whether 79 atrophic glossitis (AG) patients with microcytosis and 985 AG patient without microcytosis had higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 532 healthy control subjects. Methods: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 79 AG patients with microcytosis, 985 AG patient without microcytosis, and 532 healthy control subjects were measured and compared. Results: We found that 69.6%, 43.0%, ...
Clotrimazole, an N-substituted imidazole widely used as an antifungal agent, has been shown to both inhibit and induce hepatic cytochrome P-450 and related monooxygenase activities. In this study the profile of hepatic cytochrome P-450 isozyme(s) induced by clotrimazole treatment of male Sprague-Dawley rats was investigated. Clotrimazole administration (100 mg/kg, daily for 4 days, ig) resulted in 86% induction of spectrally detectable cytochrome P-450 in hepatic microsomes. In these microsomes 7-ethoxycoumarin O-deethylase (126%), aminopyrine N-demethylase (176%), benzphetamine N-demethylase (117%), p-nitrophenol hydroxylase (89%), and 7-ethoxyresorufin O-deethylase (62%) activities were significantly induced, whereas aryl hydrocarbon hydroxylase activity remained unchanged. Characterization of cytochrome P-450 isozyme(s) in hepatic microsomes prepared from clotrimazole-treated animals was based on the immunoreactivity of these microsomes with highly specific monoclonal antibodies (MAbs) raised ...
Biochemical, histopathological and ultrastructural changes occurring at different time points after intraperitoneal administration of a single dose of pulegone (300 mg/kg) were studied. Significant decreases in the level of liver microsomal cytochrome P-450 (67%), heme (37%), aminopyrine N-demethylase (60%) and glucose-6-phosphatase (58%), were noticed 24 hr after pulegone treatment. Alanine amino transferase (ALT) levels increased in a time dependent manner, following exposure of rats to pulegone. Light microscopic studies of liver tissues showed dilation of central veins and distention of sinusoidal spaces 6 hr after pulegone treatment. Initial centrilobular necrosis was noticed at 12 hr. Centrilobular necrosis became severe at 18 hr and nuclear changes included karyorrhexis and karyolysis. Midzonal and periportal degenerative changes in addition to centrilobular necrosis was observed 24 hr after pulegone administration. Electron microscopic changes showed severe degeneration of endoplasmic ...
Gastrointestinal malignancies are strongly linked to chronic inflammation (25-29). Gastric tumorigenesis in K19-Wnt1/C2mE mice was also recently shown to be suppressed by knockout of either TNFα or its receptor TNFR1, suggesting that TNFα-dependent inflammation plays a key role in the development of gastric cancer (30). Furthermore, the development of SPEM in response to acute parietal cell loss is dependent on the recruitment of macrophages to the gastric epithelium (31). Together, these findings suggest that inflammation triggers the histopathologic alterations of gastric epithelium that leads to tumor development. We have now shown that the inflammation-associated ROS plays a key role in the parietal cell loss that is an early and critical step in the development of SPEM, and the subsequent formation of gastric tumors. The accumulation of ROS triggers the p38MAPK-p16INK4a/p19ARF signaling pathway selectively in parietal cells and the consequent induction of parietal cell loss. In fact, ...
Unscramble aniline, Unscramble letters aniline, Point value for aniline, Word Decoder for aniline, Word generator using the letters aniline, Word Solver aniline, Possible Scrabble words with aniline, Anagram of aniline
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"Aminopyrine-N-demethylase. I. Directed modification of substrates' structure as a way of production of inducer of the ...
Aminopyrine Hart FD, Boardman PL (June 1964). "Trial of Nifenazone ("Thylin")". British Medical Journal. 1 (5397): 1553-4. doi: ...
In 1897 he invented "Pyramidon", the trade name for aminopyrine. With Arthur Stoll, he is credited with the isolation of ...
... is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. Due to the risk of ...
In 1893, a derivative of antipyrine, aminopyrine, was made by Friedrich Stolz at Hoechst. Yet later, chemists at Hoechst made a ...
A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in ... Caubet MS, Laplante A, Caillé J, Brazier JL (June 2002). "[13C]aminopyrine and [13C]caffeine breath test: influence of gender, ... Aminophenazone (or aminopyrine, amidopyrine, Pyramidon) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic ...
The compounds generally act as analgesics and include dipyrone (Metamizole), aminopyrine, ampyrone, famprofazone, morazone, ...
Imaoka S, Inoue K, Funae Y (1988). "Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: ... simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography". Arch. Biochem. Biophys. ...
... aminopyrine MeSH D03.383.129.539.850.077.025 - ampyrone MeSH D03.383.129.539.850.077.150 - dipyrone (metamizole) MeSH D03.383. ...
... aminopyrine n-demethylase MeSH D08.811.682.662.582.338 - cytochrome p-450 cyp2e1 MeSH D08.811.682.662.582.353 - cytochrome p- ...
Other names: 3H-Pyrazol-3-one, 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-; Antipyrine, 4-(dimethylamino)-; (Dimethylamino)phenazone; Amidazophen; Amidazophene; Amidofebrin; Amidofen; Amidophen; Amidophenazone; Amidopyrazoline; Amidopyrin; Amidopyrine; Aminophenazon; Aminophenazone; Aminopyrin; Anafebrina; Brufaneuxol; Dereuma; Dimapyrin; Dimethylamino-analgesine; Dimethylaminoantipyrine; Dimethylaminoazophene; Dimethylaminophenyldimethylpyrazolone; Dipirin; Dipyrin; Dipyrine; Febrinina; Febron; Itamidone; Novamidon; Piramidon; Piridol; Piromidina; Polinalin; Pyradone; Pyramidon; Pyramidone; 4-(Dimethylamino)antipyrine; 4-(Dimethylamino)phenazone; 1,5-Dimethyl-2-phenyl-4-dimethylamino-3-pyrazolone; Amidazofen; Eufibron; Hyparon; Mamallet-A; Pirazon; 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone; 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one; 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazolone-5; 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone; ...
Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological ... Aminopyrine metabolism 14CO2-breath test aminopyrine demethylation dose dependent metabolism physical fitness ... Brodie, B.B., Axelrod, J.: The fate of aminopyrine (Pyramidon) in man and methods for the estimation of aminopyrine and its ... Assessment of aminopyrine metabolism in man by breath analysis after oral administration of14C-aminopyrine. Effects of ...
Aminopyrine; Linear Formula: C13H17N3O; find Sigma-Aldrich-D8015 MSDS, related peer-reviewed papers, technical documents, ...
VALUE OF AMINOPYRINE(VALUE OF AMINOPYRINE*†)(VALUE OF AMINOPYRINE*†) LEONARD CARDON, M.D., F.A.C.P.; OSCAR H. COMESS, M.D.; ... VALUE OF AMINOPYRINE(VALUE OF AMINOPYRINE*†)(VALUE OF AMINOPYRINE*†). Ann Intern Med. 1958;48:616-634. doi: 10.7326/0003-4819- ... Aminopyrine, by force of historical circumstances, has been such a discredited drug for many years.1, 2a, 3c, 4b, 5, 6, 7, 8 ... Quantitative Assessment of Hepatic Function by Breath Analysis after Oral Administration of [14C]aminopyrine Annals of Internal ...
MF:C13H17N3O MW:231.29 CAS:58-15-1 EINECS:200-365-8 Apperance:White fronds crystal or crystalline powder. No smell, taste slightly bitter. Product use: Antipyretic and analgesic, used for fever and headache, joint pain, neuralgia, dysmenorrhea and...
The effect of a 20-day administration of aminopyrine (600 mg kg-1) as well as two metabolites of aminopyrine, 4-aminoantipyrine ... Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine.. T Satoh, T Igarashi, T ... Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine.. T Satoh, T Igarashi, T ... Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine.. T Satoh, T Igarashi, T ...
In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited ... In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited ... In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited ... In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited ...
... to understand the pain of a piece of adverse reactions and pharmacological toxicology Compound Aminopyrine Phenacetin Tablets ( ... Effect of Compound Aminopyrine Phenacetin Tablets on kidney. First, to understand the pain of a piece of adverse reactions and ... This compound contains aminopyrine and phenacetin have obvious adverse reactions. Taking the amino group can vomiting, rash, ... 2 aminopyrine react with food in the stomach, can form carcinogenic N-nitroso compounds, especially nitrosamines, therefore has ...
Aminopyrine breath test predicts surgical risk for patients with liver disease. By R A Gill, M W Goodman, G R Golfus, G R ... To determine whether the [14C] aminopyrine breath test (ABT) predicts surgical risk in patients with liver disease, it was ...
ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:, Synonyms:AMINOPYRINE , AMINOPHENAZONE CYCLAMATE , AMINOPHENAZONE , ... AMINOPYRINE. ChEMBL Synonyms AMINOPYRINE , AMINOPHENAZONE CYCLAMATE , AMINOPHENAZONE , AMIDOPYRINE. Max Phase. 4 (Approved). ...
Aminopyrine: All drug products containing aminopyrine.. Astemizole: All drug products containing astemizole. ...
14C]aminopyrine accumulation in rabbit isolated gastric glands.. In intact gastric glands from rabbits, histamine significantly ... The following drugs were used in this study: [14C]Aminopyrine (specific activity 96.6 Ci/mmol), [3H]DTG (specific activity 35.2 ... 7). Finally, BDF 6143 up to 100 μM did not alter histamine-induced [14C]aminopyrine accumulation (n = 3; results not shown). ... 7). At this high concentration, clonidine increased [14C]aminopyrine accumulation in 2 of 4 experiments, but because of the ...
... score of ascites and result of 14C aminopyrine breath test) were found to be highly effective for making this decision. ...
In rats treated with a single dose [50 mg/kg] of SKF 525-A, aminopyrine N-demethylase and aniline hydroxylase activities were ... The effects of diclofenac sodium administration, in single and repeated doses, on hepatic microsomal activities of aminopyrine ... M, in single and multiple doses on hypatic microsomal aminopyrine n-demethylase and aniline hydroxylase activities in the rat: ... M, in single and multiple doses on hypatic microsomal aminopyrine n-demethylase and anilin ...
By using the two different principle methods,the standard value and uncertainty of aminopyrine content was 99.66% ± 0.08%(k = 2 ... The valuation and uncertainty evaluation of the purity determination of aminopyrine by using HPLC and acid-base titration are ... To study the valuation and uncertainty evaluation of the purity determination of aminopyrine by two different principle methods ... Valuation and Uncertainty Evaluation of the Purity Determination of Aminopyrine by Different Methods / 中国药师 ...
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C.01.131 - Aminopyrine and Dipyrone *C.01.134 - Coated Potassium Salts *C.01.401 - Antibiotics ...
... aminopyrine, 4-aminoantipyrine [244]; minocycline [288]; Tl+ [130, 260], Ag+, H+ [130]; oxybuprocaine, prilocaine, mepivacaine ...
Aminopyrine sodium sulfonate; Analgin; Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt; (Antipyrinylmethylamino) ...
Aminopyrine; anafebrina; dimapyrin; ... ...
Aminopyrine. Phenylbutazone. PTU. Indomethacin. Tocainide 25 What is the antipsychotic drug that causes hypnagogic ...
"Aminopyrine-N-demethylase. I. Directed modification of substrates structure as a way of production of inducer of the ...
Aminopyrine and its derivatives. Cyclosporine. Amprenavir and its salts and derivatives. Cytarabine and its salts. ...
Background 14C-aminopyrine accumulation (bg) is also shown. b) Accumulation of 14C-aminopyrine in gastric glands pretreated ... Accumulation of 14C-labeled aminopyrine in db-cAMP-stimulated gastric glands. All values are expressed as percent of a value ... Accumulation of 14C-labeled aminopyrine in histamine-stimulated gastric glands. All values are expressed as percent of the ... Aminopyrine / metabolism. Arginine / pharmacology. Bucladesine / metabolism. Carbon Radioisotopes / metabolism. Enzyme ...
0 (Biomarkers); 01704YP3MO (Aminopyrine); 76W6J0943E (Flutamide); 822G987U9J (zomepirac); 83HN0GTJ6D (Cyclosporine); D8K2JPN18B ...
Aminopyrine / analogs & derivatives*. Anemia, Hemolytic / chemically induced*. Child, Preschool. Dipyrone / adverse effects*. ...
Comparison of Age-Related Peripheral Nerve Changes in Mice Housed in Either Plastic Cages with Sawdust-Covered Solid Flooring or Wire-Mesh-Floor Cages (2000 ...
DEVELOPMENT OF HEPATIC N-DEMETHYLASE ACTIVITY AS MEASURED IN VIVO BY THE AMINOPYRINE BREATH TEST *Robert J Shulman ... Rights & permissionsfor article Effect of Infant Age on Aminopyrine Breath Test Results . Opens in a new window. ... Rights & permissionsfor article DEVELOPMENT OF HEPATIC N-DEMETHYLASE ACTIVITY AS MEASURED IN VIVO BY THE AMINOPYRINE BREATH ... Effect of Infant Age on Aminopyrine Breath Test Results *Robert J Shulman ...
The effect of aminopyrine on oxygen uptake.Eur. J. Biochem. 10:459-467 (1969).PubMedCrossRefGoogle Scholar ...
Aminopyrine Hart FD, Boardman PL (June 1964). "Trial of Nifenazone ("Thylin")". British Medical Journal. 1 (5397): 1553-4. doi: ...
  • Under the same experimental condition, the amounts of cytochrome P-450 and b5, the activities of aminopyrine N-demethylase, aniline hydroxylase and carboxylesterase of liver microsomes were all induced in the aminopyrine- and 4-aminoantipyrine-treated rats. (aspetjournals.org)
  • The effects of diclofenac sodium administration , in single and repeated doses , on hepatic microsomal activities of aminopyrine N- demethylase and aniline hydroxylase were evaluated in rats . (bvsalud.org)
  • In rats treated with a single dose [50 mg/kg] of SKF 525-A, aminopyrine N-demethylase and aniline hydroxylase activities were significantly decreased, compared with control values. (bvsalud.org)
  • There was no statistical difference between C / C , C / T , and T / T dogs in activities of aminopyrine N -demethylase, aniline hydroxylase, bufuralol 1′-hydroxylase, and midazolam 1′-hydroxylase. (aspetjournals.org)
  • Also following dietary administration, hepatic microsomes were isolated and the following parameters related to in vitro drug metabolism were measured, yield of microsomal protein/g liver, in vitro activities of aniline hydroxylase and aminopyrine demethylase, content of cytochromes P-450 and b5/mg microsomal protein. (epa.gov)
  • The secretory response of the glands was determined as accumulation of [14C]aminopyrine. (biomedsearch.com)
  • Histamine dose-dependently stimulated the acid formation which was measured as the accumulation of [14C]aminopyrine. (diva-portal.org)
  • Using this method we studied the effect of CCK-like peptides on [ 14 C]aminopyrine accumulation stimulated by histamine, in order to fmd out whether such peptides can inhibit the production of acid in the parietal cell. (diva-portal.org)
  • Following culture on Matrigel coated plates, acid secretion was assessed by 14C aminopyrine accumulation. (bmj.com)
  • First, to understand the pain of a piece of adverse reactions and pharmacological toxicology Compound Aminopyrine Phenacetin Tablets (common name), Somidon piece (formerly common name), compound (phenobarbital + phenacetin caffeine + + amid. (kidneyhealthy.com)
  • Compound Aminopyrine Phenacetin Tablets (common name), Somidon piece (formerly common name), compound (phenobarbital + phenacetin caffeine + + amidopyrin). (kidneyhealthy.com)
  • Among them are the fever-reducing analgesic aminopyrine, the anti-inflammatory drug phenylbutazone, used in treating arthritis , the yellow food colour and fibre dye tartrazine, and a series of dyes used as sensitizing agents in colour photography. (britannica.com)
  • The effects on aminopyrine-demethylase and acetanilide-hydroxylase activity were evaluated. (cdc.gov)
  • Isooctane did not inhibit aminopyrine-demethylase or acetanilide-hydroxylase activity. (cdc.gov)
  • The effects on aniline-p-hydroxylase, acetanilide-hydroxylase, and aminopyrine-N- demethylase activity were investigated. (cdc.gov)
  • IPI and CPI competitively inhibited aniline-p- hydroxylase and acetanilide-hydroxylase and noncompetitively inhibited aminopyrine-N-demethylase, IPI being the more potent. (cdc.gov)
  • Brodie, B.B., Axelrod, J.: The fate of aminopyrine (Pyramidon) in man and methods for the estimation of aminopyrine and its metabolites in biological material. (springer.com)
  • The effect of a 20-day administration of aminopyrine (600 mg kg-1) as well as two metabolites of aminopyrine, 4-aminoantipyrine (525 mg kg-1) and 4-acetamidoantipyrine (635 mg kg-1), on several hepatic, kidney and serum enzyme activities were investigated. (aspetjournals.org)
  • Maximal aminopyrine N-demethylase activity of the brain was 0.5 and 17% that of the liver when expressed per milligram of microsomal protein (261.3 pmol/10 min/mg of protein) and nanomole of cytochrome P-450 (6.98 nmol/10 min/nmol of cytochrome P-450), respectively. (elsevier.com)
  • protein content (28.4 ± 0.37 and 24.2 ± 4.19 mg/mL) and aminopyrine demethylase activity (2.59 ± 0.08 and 3.48 ± 0.13 µM/g liver/5 min formaldehyde production) checked. (europa.eu)
  • Gram, T.E., Wilson, J.T., Fouts, J.R.: Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit. (springer.com)
  • The activity of CYP2H and CYP3A37, enzymes involved in biotransformation in chicken, was detected by aminopyrine N-demethylation and aniline-hydroxylation assays from the microsomal suspensions. (biomedcentral.com)
  • Hepner, G.W., Vesell, E.S.: Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14 C-aminopyrine. (springer.com)
  • Depression of aminopyrine metabolism by influenza vaccination. (wikigenes.org)
  • The medicine industry uses Sodium Bisulfite for manufacturing semifinished product of metamizole sodium and aminopyrine. (alibaba.com)
  • The single apparent Km of the brain aminopyrine N-demethylase (3.39 mM) was at least 3-fold higher than that of the liver (0.18 and 1.13 mM). (elsevier.com)
  • Coupled with data presented on the inhibitory effects of CO and SKF 525-A on brain and hepatic aminopyrine N-demethylases, the kinetic data suggest that brain aminopyrine N-demethylase exhibits behavior different from that of the liver enzyme. (elsevier.com)
  • Aminopyrine breath test predicts surgical risk for patients with liver disease. (core.ac.uk)
  • To determine whether the [14C] aminopyrine breath test (ABT) predicts surgical risk in patients with liver disease, it was obtained prior to various surgeries in 38 patients with known or suspected liver disease. (core.ac.uk)
  • Effects of in vivo hyperthermo-chemotherapeutic perfusion of the normal and regenerating liver on the aminopyrine breath test in the rats. (nii.ac.jp)
  • Clinical evaluation of (13C)-aminopyrine breath test on post-operative prognosis in patients with liver diseases. (nii.ac.jp)
  • no significant changes were noted in liver aminopyrine - N - demethylase or aniline hydrolase activities. (cdc.gov)
  • Effects of NKK-105 administration on aminopyrine N-demethylase, cyt.b 5 , cyt.p-45O and lipid peroxidation in CCl 4 -induced liver damage were investigated, in vivo. (go.jp)
  • Juxtaposition of the phenacetin and aminopyrine stir tests: implication of liver complaint, inducers and cobaltous chloride. (nippon-kan.org)
  • A Breath Test with 13C-labeled aminopyrine has been used as a non-invasive measure of Cytochrome P-450 metabolic activity in LIVER FUNCTION TESTS. (online-medical-dictionary.org)
  • This compound contains aminopyrine and phenacetin have obvious adverse reactions. (kidneyhealthy.com)
  • Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. (springer.com)
  • A Pugh score (combining five variables) superior to 8 or a p value inferior to 0.7 of a logistic regression equation containing only two variables (score of ascites and result of 14C aminopyrine breath test) were found to be highly effective for making this decision. (nih.gov)
  • Lauterburg, B.H., Bircher, J.: Expiratory measurement of maximal aminopyrine demethylation in vivo: effect of phenobarbital, partial hepatectomy, portacaval shunt and bile duct ligation in the rat. (springer.com)
  • This study was designed to characterize cytochrome P-450-dependent aminopyrine N-demethylation using microsomes from rat brain and to compare it with N-demethylation of the drug by hepatic microsomes studied in parallel. (elsevier.com)
  • Brain aminopyrine N-demethylation was linear with respect to protein concentrations and incubation times of up to 15 min. (elsevier.com)
  • In contrast to the biphasic kinetic behavior of hepatic aminopyrine N-demethylase, brain aminopyrine N-demethylation exhibited linear kinetics. (elsevier.com)
  • Spectral binding of aminopyrine, hexobarbital, androstenedione and aniline to rat brain cytochrome P-450 could not be detected, apparently because of the low concentration of the hemoprotein. (elsevier.com)
  • By using the two different principle methods,the standard value and uncertainty of aminopyrine content was 99.66% ± 0.08%(k = 2,P = 0.95). (bvsalud.org)
  • Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine. (aspetjournals.org)
  • In vitro assays with model substrates [aminopyrine, aniline, p -nitroanisole, and benzo( a )pyrene] were used to quantitate drug-metabolizing activity. (aacrjournals.org)
  • In the aminopyrine-treated group, a pronounced induction of gamma-glutamyl transpeptidase was shown in the whole homogenate as compared to that in the hepatic microsomes. (aspetjournals.org)
  • Aminopyrine N-demethylase of brain microsomes required oxygen and NADPH for optimal activity and its activity was inhibited by carbon monoxide (CO) and SKF 525-A in a concentration-dependent manner. (elsevier.com)
  • The results in this paper support the view that repeated administration of aminopyrine induces hepatic membrane-bound enzyme, particularly, gamma-glutamyl transpeptidase activity. (aspetjournals.org)
  • According to Technical Norm of Primary Reference Material and Technical Norm of Measurement,HPLC and acid-base titration were selected for studying the valuation of the purity determination of aminopyrine, and the uncertainty evaluation of the two different principle methods was systematically evaluated. (bvsalud.org)
  • Serum gamma-glutamyl transpeptidase activity was also increased by administration of aminopyrine or 4-aminoantipyrine. (aspetjournals.org)
  • NKK-105 had no effect on the activity of aminopyrine N-demethylase and the content of cyt.b5, cyt.p-450 and peroxide. (go.jp)
  • The valuation and uncertainty evaluation of the purity determination of aminopyrine by using HPLC and acid-base titration are accurate and reliable,which can avoid the defects by using single analysis method,and is helpful to improve the level of quality evaluation and control of aminopyrine. (bvsalud.org)
  • To study the valuation and uncertainty evaluation of the purity determination of aminopyrine by two different principle methods. (bvsalud.org)
  • The study provides scientific basis for the development of aminopyrine purity reference materials. (bvsalud.org)
  • 2 aminopyrine react with food in the stomach, can form carcinogenic N-nitroso compounds, especially nitrosamines, therefore has potential carcinogenicity. (kidneyhealthy.com)