Aminopyrine
Aniline Hydroxylase
Parietal Cells, Gastric
Microsomes, Liver
Antipyrine
Dipyrone
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Peroxides
A group of compounds that contain a bivalent O-O group, i.e., the oxygen atoms are univalent. They can either be inorganic or organic in nature. Such compounds release atomic (nascent) oxygen readily. Thus they are strong oxidizing agents and fire hazards when in contact with combustible materials, especially under high-temperature conditions. The chief industrial uses of peroxides are as oxidizing agents, bleaching agents, and initiators of polymerization. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Pyrazolones
Secobarbital
Seminal Vesicles
Phenobarbital
Dealkylation
Gastric Mucosa
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
NADPH-Ferrihemoprotein Reductase
Histamine
Microsomes
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Rats, Inbred Strains
Benzphetamine
Liver
Anemia, Pernicious
A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)
Lipid Peroxides
Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.
Carbamazepine
Trigeminal Neuralgia
A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
Epilepsy, Tonic-Clonic
A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
Seizures
Epilepsy, Generalized
Recurrent conditions characterized by epileptic seizures which arise diffusely and simultaneously from both hemispheres of the brain. Classification is generally based upon motor manifestations of the seizure (e.g., convulsive, nonconvulsive, akinetic, atonic, etc.) or etiology (e.g., idiopathic, cryptogenic, and symptomatic). (From Mayo Clin Proc, 1996 Apr;71(4):405-14)
Epilepsies, Partial
Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat. (1/181)
Despite its hepatotoxic potential, cyclosporine A (CsA) has been reported to positively influence compensatory liver growth. To probe the physiological consequences of CsA on the recovery of liver function, studies were initiated in the 2/3 partially hepatectomized (PHx) rat, taking the recovery of cytochromes P-450-dependent drug metabolism as primary outcome. CsA was administered at a dose of 3. 33 mg/kg/day for 10 days. Drug metabolism was evaluated by the recovery of 14CO2 after administration of isotopically labeled model drugs and by studying the expression of the P-450 transcripts involved in their biotransformation before and 24 to 96 h after PHx. Before PHx, neither the steady-state mRNA nor the in vivo disposition of caffeine (CYP1A2), erythromycin (CYP3A2 and 3A1), or aminopyrine (CYP2B1 and 2C11) were influenced by CsA. Studies 24 h after PHx revealed a 29 to 39% reduction in the elimination of [14C]aminopyrine and [14C]erythromycin, which was unaffected by CsA. Their metabolism at 48 to 96 h after PHx also remained unaffected by CsA. By contrast, postPHx, [14C]caffeine elimination decreased to a level closely proportional to the loss in liver mass. In addition, CsA accelerated the recovery and/or prevented the decrease of caffeine elimination 24 h after PHx but not at later time points, indicating an early, but unsustained, beneficial effect of CsA on the recovery of CYP1A2-mediated activities. These data show that at the critical time of greatest loss in liver mass, CsA has only a selective influence on the biotransformation of cytochrome P-450 protein-dependent activities and that its effect on the regeneration process does not translate into an overall accelerated recovery of the hepatic drug-metabolizing function. (+info)L-365,260 inhibits in vitro acid secretion by interacting with a PKA pathway. (2/181)
The aim of this study was to analyse the antisecretory mechanism of L-365,260 in vitro in isolated rabbit gastric glands. We showed that compound L-365,260, described as a non-peptide specific competitive CCK-B receptor antagonist, was able to dose-dependently inhibit [14C]-aminopyrine accumulation induced by histamine (10(-4) M), carbachol (5x10(-5) M), 3-isobutyl-1-methyl-xanthine (IBMX) (5x10(-6) M) and forskolin (5x10(-7) M) with similar IC50 values respectively of 1.1+/-0.6x10(-7) M, 1.9+/-1.2x10(-7) M, 4.2+/-2.0x10(-7) M and 4.0+/-2.8x10(-7) M. We showed that L-365,260 acted beyond receptor activation and production of intracellular second messengers and that it had no action on the H+/K+ -ATPase. We found that L-365,260 inhibited cyclic AMP-induced [14C]-aminopyrine accumulation in digitonin-permeabilized rabbit gastric glands, suggesting that this compound acted, at least in part, as an inhibitor of the cyclic AMP-dependent protein kinase (PKA) pathway. (+info)Demethylation capacity of human fetal adrenal mitochondrial cytochrome P-450 in vitro. (3/181)
AIM: To explore the capacity and characteristics of adrenal mitochondria to metabolize xenobiotics in vitro in human fetus. METHODS: Subcellular fractions of fetal adrenal were prepared by differential centrifugation. Mitochondrial P-450 system was proved by spectral analyses and SDS-PAGE. The formaldehyde formation contents were measured with Nash reagent. RESULTS: The erythromycin N-demethylation linearly increased in the protein concentration (1-4 mg)- and incubation time (10-30 min)-dependent manners. A typical concentration-effect relationship appeared with erythromycin 0.067-1 mmol.L-1 and a positive correlation (r = 0.641, P < 0.05) existed between erythromycin N-demethylation and gestation months. The N-demethylation values (nmol.s-1/g protein) of erythromycin (2.7 +/- 0.8), benzfetamine (1.1 +/- 0.5), and aminophenazone (0.9 +/- 0.4) in mitochondria were 89% (P > 0.05), 162% (P < 0.01), and 62% (P < 0.01), respectively, of those in microsomes. There was correlation between mitochondria and microsomes in the N-demethylation of erythromycin (r = 0.708, P < 0.05) and benzfetamine (r = 0.707, P < 0.05). Troleandomycin stimulated erythromycin N-demethylation in adrenal mitochondria as well as in adrenal and liver microsomes in vitro. CONCLUSION: Fetal adrenal mitochondria, with multiple P-450 isoforms and greater capacity of demethylation, play a role in drug-metabolism during fetal development. (+info)Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. (4/181)
Stimulation of the gastric parietal cell results in a massive redistribution of H+-K+-ATPase from cytoplasmic tubulovesicles to the apical plasma membrane. Previous studies have implicated the small GTPase rab11 in this process. Using matrix-assisted laser desorption mass spectrometry, we confirmed that rab11 is associated with H+-K+-ATPase-enriched gastric microsomes. A stoichiometry of one rab11 per six copies of H+-K+-ATPase was estimated. Furthermore, rab11 exists in at least three forms on rabbit gastric microsomes: the two most prominent resemble rab11a, whereas the third resembles rab11b. Using an adenoviral expression system, we expressed the dominant negative mutant rab11a N124I in primary cultures of rabbit parietal cells under the control of the tetracycline transactivator protein (tTA). The mutant was well expressed with a distribution similar to that of the H+-K+-ATPase. Stimulation of these cultures with histamine and IBMX was assessed by measuring the aminopyrine (AP) uptake relative to resting cells (AP index). In experiments on six culture preparations, stimulated uninfected cells gave an AP index of 10.0 +/- 2.9, whereas parallel cultures expressing rab11a N124I were poorly responsive to stimulation, with a mean AP index of 3.2 +/- 0. 9. Control cultures expressing tTA alone or tTA plus actin responded equally well to stimulation, giving AP index values of 9.0 +/- 3.1 and 9.6 +/- 0.9, respectively. Thus inhibition by rab11a N124I is not simply due to adenoviral infection. The AP uptake data were confirmed by immunocytochemistry. In uninfected cells, H+-K+-ATPase demonstrated a broad cytoplasmic distribution, but it was cleared from the cytoplasm and associated with apically derived membranes on stimulation. In cells expressing rab11a N124I, H+-K+-ATPase maintained its resting localization on stimulation. Furthermore, this effect could be alleviated by culturing infected cells in the presence of tetracycline, which prevents expression of the mutant rab11. We therefore conclude that rab11a is the prominent GTPase associated with gastric microsomes and that it plays a role in parietal cell activation. (+info)Responsiveness of beta-escin-permeabilized rabbit gastric gland model: effects of functional peptide fragments. (5/181)
We established a beta-escin-permeabilized gland model with the use of rabbit isolated gastric glands. The glands retained an ability to secrete acid, monitored by [14C]aminopyrine accumulation, in response to cAMP, forskolin, and histamine. These responses were all inhibited by cAMP-dependent protein kinase inhibitory peptide. Myosin light-chain kinase inhibitory peptide also suppressed aminopyrine accumulation, whereas the inhibitory peptide of protein kinase C or that of calmodulin kinase II was without effect. Guanosine-5'-O-(3-thiotriphosphate) (GTPgammaS) abolished cAMP-stimulated acid secretion concomitantly, interfering with the redistribution of H+-K+-ATPase from tubulovesicles to the apical membrane. To identify the targets of GTPgammaS, effects of peptide fragments of certain GTP-binding proteins were examined. Although none of the peptides related to Rab proteins showed any effect, the inhibitory peptide of Arf protein inhibited cAMP-stimulated secretion. These results demonstrate that our new model, the beta-escin-permeabilized gland, allows the introduction of relatively large molecules, e.g., peptides, into the cell, and will be quite useful for analyzing signal transduction of parietal cell function. (+info)Regulation and function of p38 protein kinase in isolated canine gastric parietal cells. (6/181)
We examined the regulation and functional role of p38 kinase in gastric acid secretion. p38 kinase was immunoprecipitated from cell lysates of highly purified gastric parietal cells in primary culture, and its activity was quantitated by in vitro kinase assay. Carbachol effects were dose- and time-dependent, with a maximal 10-fold stimulatory effect detected after 30 min of incubation. SB-203580, a highly selective inhibitor of p38 kinase, blocked carbachol induction of p38 kinase activity, with maximal inhibition at 10 microM. Stimulation by carbachol was unaffected by preincubation of parietal cells with the intracellular Ca(2+) chelator BAPTA-AM, but incubation of cells in Ca(2+)-free medium led to a 50% inhibition of carbachol induction of p38 kinase activity. Because some of the effects of carbachol are mediated by the small GTP-binding protein Rho, we examined the role of Rho in carbachol induction of p38 kinase activity. We tested the effect of exoenzyme C3 from Clostridium botulinum (C3), a toxin known to ADP-ribosylate and specifically inactivate Rho. C3 led to complete ADP-ribosylation of Rho, and it inhibited carbachol induction of p38 kinase by 50%. We then tested the effect of SB-203580 and C3 on carbachol-stimulated uptake of [(14)C]aminopyrine (AP). Inhibition of p38 kinase by SB-203580 led to a dose-dependent increase in AP uptake induced by carbachol, with maximal (threefold) effect at 10 microM SB-203580. Similarly, preincubation of parietal cells with C3 led to a twofold increase in AP uptake induced by carbachol. Thus carbachol induces a cascade of events in parietal cells that results in activation of p38 kinase through signaling pathways that are at least in part dependent on Rho activation and on the presence of extracellular Ca(2+). p38 kinase appears to inhibit gastric acid secretion. (+info)Tryptophan operon read-through. Isolation and characterization of an abnormally long tryptophan synthetase alpha subunit from a frame-shift mutant of Escherichia coli. (7/181)
A new mutant strain of Escherichia coli, strain ICR-47, contains a frame-shift mutation in the trpA gene, the gene most distal to the operator in the trp operon. Mapping experiments indicate that the lesion is located at a site within 10 to 15% of the end of this gene. The mutation results in "out-of-phase" translation of the distal portion of the trp mRNA; normal translational termination signal(s) are not encountered and a trpA gene product longer than the wild type protein is produced. As with the other enzymes produced from this operon, the in vivo level of the altered protein (the alpha subunit of the tryptophan synthetase enzyme complex) is controlled by exogenous L-tryptophan. The altered alpha subunit from the strain ICR-47 has been isolated and characterized. Molecular weight estimations indicate a molecular weight of approximately 37,000, an increase beyond the wild type enzyme corresponding to an additional 50 to 70 amino acid residues. The protein has a new COOH-terminal amino acid sequence. Results of preliminary hybridization experiments suggest that the ICR-47 mRNA, which is necessarily longer than that needed to code for wild type enzyme, is not detectably different in size from wild type mRNA. The enzymatic properties of the ICR-47 alpha subunit indicates a greatly reduced ability of the mutant subunit to combine functionally with wild type beta2 subunit, the second protein component in the tryptophan synthetase enzyme complex. In contrast, only 40 to 50% of the intrinsic enzymatic activity of the alpha subunit is lost. (+info)A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol. (8/181)
Acid secretion in isolated rabbit gastric glands was monitored by the accumulation of [(14)C]aminopyrine. Stimulation of the glands with carbachol synergistically augmented the response to dibutyryl cAMP. The augmentation persisted even after carbachol was washed out and was resistant to chelated extracellular Ca(2+) and to inhibitors of either protein kinase C or calmodulin kinase II. Cytochalasin D at 10 microM preferentially blocked the secretory effect of carbachol and its synergism with cAMP, whereas it had no effect on histamine- or cAMP-stimulated acid secretion within 15 min. Cytochalasin D inhibited the carbachol-stimulated intracellular Ca(2+) concentration ([Ca(2+)](i)) increase due to release from the Ca(2+) store. Treatment of the glands with cytochalasin D redistributed type 3 inositol 1,4,5-trisphosphate receptor (the major subtype in the parietal cell) from the fraction containing membranes of large size to the microsomal fraction, suggesting a dissociation of the store from the plasma membrane. These findings suggest that intracellular Ca(2+) release by cholinergic stimulation is critical for determining synergism with cAMP in parietal cell activation and that functional coupling between the Ca(2+) store and the receptor is maintained by actin microfilaments. (+info)
Amidopyrine synonyms, amidopyrine antonyms - FreeThesaurus.com
Dose dependence of the14C-aminopyrine breath test | SpringerLink
Characterization of oxyntic glands isolated from the rat gastric mucosa
Aminophenazone - Wikipedia
Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity.
| DIAL.pr - BOREAL
VALUE OF AMINOPYRINE*† | Annals of Internal Medicine | American College of Physicians
Aminopyrine Aminophenazone AmidopyrineCAS:58-15-1 - Wuhan Carphetin Chemical Co.,LTD - ecplaza.net
In Vitro Technology - International Society for the Study of Xenobiotics
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Novodone (Aminophenazone Guaiacolglycolate; Calcium Monoethylcamphorate; Vitamin A...) AGIPS Farmaceutici
BR-4935
Summary Report | CureHunter
Amidopyrine - Medical Dictionary online-medical-dictionary.org
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Effect of a Campylobacter pylori protein on acid secretion by parietal cells
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SMART: Secondary literature for RasGEFN domain
The blood gastrin curve after histamine stimulation and a protein meal in common diseases of the digestive tract]. - Semantic...
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Parietal cell - Stock Image F002/0341 - Science Photo Library
Proper gastric gland | definition of proper gastric gland by Medical dictionary
False-colour SEM of gastric glands of stomach - Stock Image P510/0042 - Science Photo Library
Zippyshare.com - Queer On Acid - New Path (Taran & Lomov Remix) [TraxCrate.com].mp3
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Metabolism and toxicity of various xenobiotics in vitamin B1 deficiency and after administration of thiamine and thiamine...
Monoclonal conversion in human gastric glands gives insights into stem cell and clonal architecture - Experimental Medicine...
Dipyrone - Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Hepatic Dose | Drug Index | Pediatric...
Ipl Acne Therapy Treatment | Spirits List
Alteration of drug metabolizing enzymes in sulphite oxidase deficiency | AVESİS
Biotransformation of some pyrazole derivatives to glutathione conjugates in rat liver subcellular fractions.
Dipyrone - Biology-Online Dictionary
Ultrastructural and morphometric features of the acetylcholine innervation in adult rat parietal cortex: An electron...
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A&P Lab Flashcards
Gentaur Molecular :Nacala \ Aniline \ 02915-25
Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis...
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Biochemical, histopathological and ultrastructural changes in rat liver induced by r-( + )-pulegone, a monoterpene ketone -...
Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis | Cancer...
Unscramble aniline | Words unscrambled from letters aniline | Scrabble Word aniline | Words Made with the Letters aniline
Hologram from Filth on Acid on Beatport
Breath Test | BAC
can a minor refuse to submit to a breath test
Ilya B. Tsyrlov
Tsyrlov, I. B.; Gerasimov, K. E. (1991). "Aminopyrine-N-demethylase. I. Directed modification of substrates' structure as a way ...
Aminophenazone
... (or aminopyrine, amidopyrine, Pyramidon) is a non-narcotic analgesic substance. It is a pyrazolone and a ... A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in ... Caubet MS, Laplante A, Caillé J, Brazier JL (June 2002). "[13C]aminopyrine and [13C]caffeine breath test: influence of gender, ... Panchal, J (29 January 2021). "A Review: Why Aminopyrine Banned?" (PDF). Scholars Academic Journal of Pharmacy. "Aminophenazone ...
Nifenazone
Aminopyrine Hart FD, Boardman PL (June 1964). "Trial of Nifenazone ("Thylin")". British Medical Journal. 1 (5397): 1553-4. doi: ...
Karl Spiro
In 1897 he invented "Pyramidon", the trade name for aminopyrine. With Arthur Stoll, he is credited with the isolation of ...
Ampyrone
... is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. Its use as a drug is ...
Metamizole
In 1893, a derivative of antipyrine, aminopyrine, was made by Friedrich Stolz at Hoechst.: 26-27 Yet later, chemists at Hoechst ...
Unspecific monooxygenase
Imaoka S, Inoue K, Funae Y (1988). "Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: ... simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography". Arch. Biochem. Biophys. ...
2,2',3,3',4,4'-Hexachlorobiphenyl
... hexachlorobiphenyl found increased activation of ethoxyresorufin deethylase and aminopyrine demethylase. However, while also ...
List of MeSH codes (D03)
... aminopyrine MeSH D03.383.129.539.850.077.025 - ampyrone MeSH D03.383.129.539.850.077.150 - dipyrone (metamizole) MeSH D03.383. ...
C13H17N3O
... or aminopyrine PNU-91356A (U-91356) This set index page lists chemical structure articles associated with the same molecular ...
List of MeSH codes (D08)
... aminopyrine n-demethylase MeSH D08.811.682.662.582.338 - cytochrome p-450 cyp2e1 MeSH D08.811.682.662.582.353 - cytochrome p- ...
13C-aminopyrine breath test to evaluate severity of disease in patients with chronic hepatitis C virus infection<...
Breath samples were collected every 30 min up to 2 h after 13C-aminopyrine administration. 13C-Aminopyrine breath test results ... Breath samples were collected every 30 min up to 2 h after 13C-aminopyrine administration. 13C-Aminopyrine breath test results ... Breath samples were collected every 30 min up to 2 h after 13C-aminopyrine administration. 13C-Aminopyrine breath test results ... Breath samples were collected every 30 min up to 2 h after 13C-aminopyrine administration. 13C-Aminopyrine breath test results ...
IMSEAR at SEARO: Analgesics. V. Pyrazolon derivatives: antipyrine (phenazone), aminopyrine (pyramidon), and phenylbutazone ...
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Aminopyrine N-demethylase (APND) activity-CYP3A1/2. Activity was determined by the quantification of CH2O release, according to ... The total incubation volume was 3 ml, composed of 0.5 ml water solution of 50 mM aminopyrine and 25 mM MgCl2, 1.48 ml of 0.60 ... Incubation mixture consisted of 2.6 ml, composed of 1 mM ethoxycoumarin, 5 mM MgCl2, NADPH-generating system (see aminopyrine ... Acetonitrile (PubChem CID:6342), aminopyrine (PubChem CID:6009), bovine serum albumin, dichlorophenolindophenol (PubChem CID: ...
Food and Drug Regulations
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Pepcid (Famotidine): Uses, Dosage, Side Effects, Interactions, Warning
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The activity rate of aminopyrine N-demethylase was not changed by the diet; however, p-nitroanisole O-demethylase activity was ... The activity rate of aminopyrine N-demethylase was not changed by the diet; however, p-nitroanisole O-demethylase activity was ... The activity rate of aminopyrine N-demethylase was not changed by the diet; however, p-nitroanisole O-demethylase activity was ...
Légis Québec
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786. Ethyl-1-hexanol, 2- (WHO Food Additives Series 32)
Food and Drug Regulations
Aminopyrine and Dipyrone. C.01.131 No person shall sell Aminopyrine or Dipyrone (a derivative of Aminopyrine) for oral or ... C.01.133 The provisions of sections C.01.131 and C.01.132 do not apply to preparations containing Aminopyrine or Dipyrone that ... Bearing in mind the possibility that such reactions may occur, Aminopyrine or Dipyrone should be used only when other less ... "WARNING: Fatal agranulocytosis may be associated with the use of Aminopyrine and Dipyrone. It is essential that adequate blood ...
DeCS
Aminopyrine - Preferred Concept UI. M0000965. Scope note. A pyrazolone with analgesic, anti-inflammatory, and antipyretic ... Aminopyrine Entry term(s). Amidazophen Amidophen Amidophenazon Amidopyrine Aminofenazone Aminophenazone Dimethyl N ... A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in ... A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in ...
Neutropenia: Practice Essentials, Background, Pathophysiology
Antipyrine1
- V. Pyrazolon derivatives: antipyrine (phenazone), aminopyrine (pyramidon), and phenylbutazone (butazolidin). (who.int)
Demethylase4
- Comparison with aminopyrine N-demethylase activity. (aspetjournals.org)
- no significant changes were noted in liver aminopyrine - N - demethylase or aniline hydrolase activities. (cdc.gov)
- Oral administration of kopsinine 200 mg/kg once daily for 3 d significantly increased liver microsomal protein, cytochrome P-450, cytochrome b5, NADPH-cytochrome C reductase, aminopyrine demethylase and benzo(a)pyrine hydroxylase activities in mice. (chinaphar.com)
- Metyrapon, a specific inhibitor of cytochrome P-450, partially antagonized aminopyrine demethylase activity of microsomes from mice treated with kopsinine. (chinaphar.com)
Dipyrone2
Oxidation1
- From in vitro experiments, all three had been found to be potent inhibitors of oxidation of Kind-I substrates (ethylmorphine and aminopyrine) and less potent, non-competitive inhibitors of Sort-II substrates (aniline and dimethylnitrosamine). (findnolvadex.com)
Breath test11
- Background: There are few data on the use of the 13 C-aminopyrine breath test to evaluate the severity of disease in patients with hepatitis C virus-related chronic liver disease, although these patients represent one of the most important problems in clinical hepatology. (elsevier.com)
- Aims: To compare 13 C-aminopyrine breath test results of patients with hepatitis C virus-related chronic hepatitis and Child-Pugh class A cirrhosis with those of normal subjects, and to evaluate different methods of expressing 13 C-aminopyrine breath test results. (elsevier.com)
- Methods: Twenty-four patients with hepatitis C virus-related chronic hepatitis and 17 patients with Child-Pugh class A cirrhosis underwent 13 C-aminopyrine breath test. (elsevier.com)
- 13 C-Aminopyrine breath test results were expressed as a percentage of the administered dose of 13 C recovered per hour (% dose/h) and the cumulative percentage of administered dose of 13 C recovered over time (% dose cum). (elsevier.com)
- The fibrosis score showed a significant inverse correlation with the 13 C-aminopyrine breath test result (% dose/h) at 30 min (rs = - 0.409, P = 0.05). (elsevier.com)
- The 13 C-aminopyrine breath test results (% dose cum) at 30. (elsevier.com)
- The 13 C-aminopyrine breath test result (% dose cum) was also able to distinguish between normal subjects and chronic hepatitis patients with high but not low fibrosis scores. (elsevier.com)
- Both 13 C-aminopyrine breath test results (% dose/h and % dose cum) at 120 min allowed the differentiation between normal subjects and chronic hepatitis patients with high (≥ 6) necro-inflammatory activity. (elsevier.com)
- Conclusions: In patients with hepatitis C virus-related chronic liver disease, the 13 C-aminopyrine breath test proved to be safe and easy to perform, and was able to evaluate different degrees of liver function impairment which were partly correlated to clinical and histological evaluation. (elsevier.com)
- In future studies, 13 C-aminopyrine breath test results should be expressed in a standardized fashion to permit comparison. (elsevier.com)
- A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS . (bvsalud.org)
Administration1
- Breath samples were collected every 30 min up to 2 h after 13 C-aminopyrine administration. (elsevier.com)
Measure1
- Isoproterenol (Iso), epinephrine and norepinephrine each stimulated isolated gastric mucosal parietal cells as shown by an increased accumulation of [14C]aminopyrine (AP), an indirect measure of acid secretion. (aspetjournals.org)
Breath13
- The aminopyrine breath test has been shown to be a sensitive noninvasive indicator of liver cell dysfunction. (nih.gov)
- In a search for a noninvasive method of monitoring the effects of methotrexate therapy, we have investigated the use of the aminopyrine breath test in patients receiving methotrexate for the treatment of severe psoriasis. (nih.gov)
- The [14C]-aminopyrine breath test was performed in 20 normal control subjects, 32 patients with psoriasis receiving methotrexate therapy, and 8 patients with histologically confirmed cirrhosis of differing etiology. (nih.gov)
- The aminopyrine breath test was only able to detect the later severe stages of methotrexate hepatotoxicity, grade III, when fibrosis occurs, before established cirrhosis was present. (nih.gov)
- Our data suggests that the aminopyrine breath test is not a sensitive indicator for the detection of early methotrexate-induced hepatotoxicity, (stages I and II), but will detect the precirrhotic stage III change. (nih.gov)
- Consequently, we recommend that a liver biopsy should be performed annually in all psoriatic patients receiving methotrexate, to detect histological damage, especially when the aminopyrine breath test score falls below the 95% confidence limits of normal. (nih.gov)
- 7. Aminopyrine breath test predicts liver-related events and death in HCV-related cirrhosis on SVR after DAA therapy. (nih.gov)
- A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS . (nih.gov)
- To determine whether Type II diabetes or glyburide affect hepatic drug metabolism, the authors used 13 C‐labeled aminopyrine and caffeine breath tests as in vivo probes of the hepatic cytochrome P450 and P 1 450 enzyme activities respectively in six subjects with Type II diabetes (4 women, 2 men). (northwestern.edu)
- The caffeine and aminopyrine breath tests (CBT, ABT) were performed sequentially while fasting before the start of glyburide treatment (5 mg daily) and at weekly intervals for 4 weeks. (northwestern.edu)
- Type II diabetes that is poorly controlled by diet alone is not associated with alterations of the hepatic drug metabolizing enzymes as judged by the caffeine and aminopyrine breath tests. (northwestern.edu)
- 13 C-Aminopyrine breath test to evaluate severity of disease in patients with chronic hepatitis C virus infection. (rackfish.net)
- 1) The 14C-aminopyrine breath test was used to measure liver function in 14 normal subjects, 16 patients with alcoholic cirrhosis, 14 alcoholics without cirrhosis, and 29 patients taking a variety of drugs. (comparewords.com)
Caffeine1
- And because ginseng is very difficult to produce, it may also have sugar, caffeine, alcohol, phenylbutazone, aminopyrine and other substandard herbs just to "fluff up" their product.Our organic ginseng powder contains pure, unadulterated ginseng. (impactfoods.co.uk)
Enzymes1
- Both cryoprotectant media were equally efficient at preserving enzyme activities in the hepatocytes over 7 days at -80 degrees C. Cytochrome P450 and reduced glutathione content and the activities of the microsomal enzymes responsible for aminopyrine N-demethylation and epoxide hydrolysis were well maintained over 7 days storage. (nih.gov)
Phenacetin1
- Brodie and Axelrod continued to collaborate on a number of projects related to the metabolism of analgesic drugs including phenacetin, antipyrine, aminopyrine, and dicoumerol. (nih.gov)
Liver1
- 1968). Eugenol had no effect on aminopyrine-N-demethylation activity in the liver of rats given about 10% of the LD 50 three times daily for 2-2/3 days. (inchem.org)
Rats1
- Kinetics of 13C02 exhaled by rats after [~3C2]-aminopyrine in normal condi- tions (Basal) and 5 rain after administration of a dose of 164 mgkg of diethyldithiocar- bamate. (findbinaryoption.com)
Pharmaceutical1
- 5 ]. It also allows pharmaceutical compa- tional allocation technique, where 30 en- nies to expand their market [ 6 ]. (who.int)
Compound2
- PubChem Compound Summary for CID 6009, Aminopyrine. (vibratist.com)
- https://pubchem.ncbi.nlm.nih.gov/compound/Aminopyrine. (vibratist.com)
Sensitive1
- Quinidine sulfate is heat resistant or sensitive to oxidation, 7 ml of the discovered since aminopyrine. (thehasse.org)