Aminopyridines
4-Aminopyridine
Nisin
Judgment
Reference Standards
National Institutes of Health (U.S.)
Sound
Sciatic Nerve
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Central Nervous System Agents
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
Neural Conduction
Ataxia
Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Kv1.1 Potassium Channel
Cerebellar Ataxia
Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)
Acetazolamide
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Isaacs Syndrome
A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
Spinocerebellar Ataxias
A group of dominantly inherited, predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)
Nystagmus, Pathologic
Involuntary movements of the eye that are divided into two types, jerk and pendular. Jerk nystagmus has a slow phase in one direction followed by a corrective fast phase in the opposite direction, and is usually caused by central or peripheral vestibular dysfunction. Pendular nystagmus features oscillations that are of equal velocity in both directions and this condition is often associated with visual loss early in life. (Adams et al., Principles of Neurology, 6th ed, p272)
Biperiden
A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
Vestibular Nuclei
Nystagmus, Congenital
Nystagmus present at birth or caused by lesions sustained in utero or at the time of birth. It is usually pendular, and is associated with ALBINISM and conditions characterized by early loss of central vision. Inheritance patterns may be X-linked, autosomal dominant, or recessive. (Adams et al., Principles of Neurology, 6th ed, p275)
Pursuit, Smooth
Semicircular Canals
Three long canals (anterior, posterior, and lateral) of the bony labyrinth. They are set at right angles to each other and are situated posterosuperior to the vestibule of the bony labyrinth (VESTIBULAR LABYRINTH). The semicircular canals have five openings into the vestibule with one shared by the anterior and the posterior canals. Within the canals are the SEMICIRCULAR DUCTS.
Publishing
Orthodontics
Hydrogen Bonding
Cerebellar Diseases
Neurosciences
Vertigo
An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)
Methemoglobinemia
The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Directories as Topic
Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. (1/650)
To investigate the roles of calcium-binding proteins in degranulation, we used three anti-allergic drugs, amlexanox, cromolyn and tranilast, which inhibit IgE-mediated degranulation of mast cells, as molecular probes in affinity chromatography. All of these drugs, which have different structures but similar function, scarcely bound to calmodulin in bovine lung extract, but bound to the same kinds of calcium-binding proteins, such as the 10-kDa proteins isolated in this study, calcyphosine and annexins I-V. The 10-kDa proteins obtained on three drug-coupled resins and on phenyl-Sepharose were analysed by reversed-phase HPLC. It was found that two characteristic 10-kDa proteins, one polar and one less polar, were bound with all three drugs, although S100A2 (S100L), of the S100 family, was bound with phenyl-Sepharose. The cDNA and deduced amino acid sequence proved our major polar protein to be identical with the calcium-binding protein in bovine amniotic fluid (CAAF1, S100A12). The cDNA and deduced amino acid sequence of the less-polar protein shared 95% homology with human and mouse S100A13. In addition, it was demonstrated that the native S100A12 and recombinant S100A12 and S100A13 bind to immobilized amlexanox. On the basis of these findings, we speculate that the three anti-allergic drugs might inhibit degranulation by binding with S100A12 and S100A13. (+info)Differential discrimination of G-protein coupling of serotonin(1A) receptors from bovine hippocampus by an agonist and an antagonist. (2/650)
We have studied the effect of guanosine-5'-O-(3-thiotriphosphate) (GTP-gamma-S), a non-hydrolyzable analogue of GTP, on agonist and antagonist binding to bovine hippocampal 5-hydroxytryptamine (5-HT)(1A) receptor in native membranes. Our results show that the specific binding of the agonist is inhibited with increasing concentrations of GTP-gamma-S along with a reduction in binding affinity. In sharp contrast to this, antagonist binding to 5-HT(1A) receptor shows no significant reduction and remains invariant over a large range of GTP-gamma-S concentrations. The binding affinity of the antagonist also remains unaltered. This shows that the agonist and the antagonist differentially discriminate G-protein coupling of 5-HT(1A) receptors from bovine hippocampus. (+info)Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells. (3/650)
1. The relationships between the density of dopamine D4.4 receptors and the agonist efficacies of L-745,870 (3-(4-[4-chlorophhenyl]piperazin-1-yl)-methyl-1H-pyrrolo [2, 3-b]pyridine) and U-101958 ((1-benzyl-piperidin-4-yl)-(3-isopropoxy-pyridin-2-yl)-methyl-a min e) were investigated in Chinese hamster ovary (CHO) cells, after treatment with the gene expression enhancer, sodium butyrate. 2. In CHO cells expressing D4.4 receptors (CHO/D4 cells), dopamine inhibited forskolin-stimulated cyclic AMP accumulation (Emax 56+/-1% inhibition, pEC50 7.4+/-0.1, n=10). U-101958 behaved as a partial agonist (39+/-7% the efficacy of dopamine, pEC50 8.1+/-0.3, n=4), whereas L-745,870 had no detectable agonist effect. 3. Receptor density, as estimated by [3H]-spiperone saturation binding was 240+/-30 fmol mg-1 protein (n=8) in CHO/D4 cell homogenates. It reached 560+/-150 (n=6), 1000+/-190 (n=4) and 840+/-120 (n=4) fmol mg-1 protein after treatment with sodium butyrate (5 mM) for 6, 18 and 48 h, respectively. 4. The increase in receptor density was associated with a gradual enhancement of the agonist effects (increased Emax and pEC50 values) of dopamine. The efficacy of U-101958 (relative to dopamine) doubled and L-745,870 was turned into a partial agonist (efficacy 49% relative to dopamine, pEC50 8. 6+/-0.2, n=6, after 48 h treatment with sodium butyrate). These agonist effects of U-101958 and L-745,870 could be antagonized by spiperone (0.1 microM) but not by raclopride (10 microM). 5. The results show that U-101958 and L-745,870 are partial agonists at human dopamine D4.4 receptors expressed in CHO cells. Their efficacy is governed by receptor density. Agonist effects of these two compounds in vivo cannot be excluded under circumstances of increased receptor levels. (+info)Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis. (4/650)
The Arg-Gly-Asp (RGD)-binding integrin alpha(V)beta(3) is highly expressed on osteoclasts and has been proposed to mediate cell-matrix adhesion required for osteoclast-mediated bone resorption. Antagonism of this receptor should prevent stable osteoclast adhesion and thereby inhibit bone resorption. We have generated an orally bioavailable, nonpeptide RGD mimetic alpha(v)beta(3) antagonist, SB 265123, which prevents bone loss in vivo when dosed by oral administration. SB 265123 binds alpha(v)beta(3) and the closely related integrin alpha(v)beta(5) with high affinity (K(i) = 3.5 and 1.3 nM, respectively), but binds only weakly to the related RGD-binding integrins alpha(IIb)beta(3) (K(i) >1 microM) and alpha(5)beta(1) (K(i) >1 microM). The compound inhibits alpha(v)beta(3)-mediated cell adhesion with an IC(50) = 60 nM and more importantly, inhibits human osteoclast-mediated bone resorption in vitro with an IC(50) = 48 nM. In vivo, SB 265123 completely blocks bone resorption in a thyroparathyroidectomized rat model of acute bone resorption when dosed at 2.5 mg/kg/h by continuous i.v. infusion. When dosed orally with 3 to 30 mg/kg b.i.d. , in the ovariectomy-induced rat model of osteoporosis, SB 265123 prevents bone resorption in a dose-dependent fashion. This is the first report of an orally active alpha(v)beta(3) antagonist that is effective at inhibiting bone resorption when dosed in a pharmaceutically acceptable fashion. Such a molecule may provide a novel therapeutic agent for the treatment of postmenopausal osteoporosis. (+info)Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist. (5/650)
Allometric scaling may be used in drug development to predict the pharmacokinetics of xenobiotics in humans from animal data. Although allometry may be successful for compounds that are excreted unchanged or that are oxidatively metabolized (with corrections for metabolic capacity), it has been more challenging for compounds excreted primarily as conjugates in bile. (S)-10, 11-Dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[ a, d]cycloheptene-10-acetic acid (SB-265123) is a novel alphavbeta3 ("vitronectin receptor") antagonist. In this study, the in vivo pharmacokinetics and in vitro plasma protein binding of SB-265123 were examined in four species: mice, rats, dogs, and monkeys. In monkeys and dogs, SB-265123 exhibited moderate clearance, whereas low clearance (<20% hepatic blood flow) was observed in the rat, and high clearance (>70% hepatic blood flow) was seen in the mouse. The concentration-time profiles indicated the possibility of enterohepatic recirculation; subsequent studies in bile duct-cannulated rats demonstrated extensive biliary excretion of an acyl-glucuronide of SB-265123. In allometric scaling to predict the disposition of SB-265123 in humans, various standard correction factors were applied, including protein binding, maximum lifespan potential, and brain weight; each failed to produce adequate interspecies scaling of clearance (r(2) < 0.72). Consequently, a novel correction factor incorporating bile flow and microsomal UDP-glucuronosyltransferase activity in each species was applied, demonstrating substantial improvement in the correlation of the allometric plot (r(2) = 0.96). This study demonstrates a novel allometric correction that may be applicable to compounds that undergo conjugation and biliary excretion. (+info)Specific inhibition of the eubacterial DNA ligase by arylamino compounds. (6/650)
All known DNA ligases catalyze the formation of a phosphodiester linkage between adjacent termini in double-stranded DNA via very similar mechanisms. The ligase family can, however, be divided into two classes: eubacterial ligases, which require NAD(+) as a cofactor, and other ligases, from viruses, archaea, and eukaryotes, which use ATP. Drugs that discriminate between DNA ligases from different sources may have antieubacterial activity. We now report that a group of arylamino compounds, including some commonly used antimalarial and anti-inflammatory drugs and a novel series of bisquinoline compounds, are specific inhibitors of eubacterial DNA ligases. Members of this group of inhibitors have different heterocyclic ring systems with a common amino side chain in which the two nitrogens are separated by four carbon atoms. The potency, but not the specificity of action, is influenced by the DNA-binding characteristics of the inhibitor, and the inhibition is noncompetitive with respect to NAD(+). The arylamino compounds appear to target eubacterial DNA ligase in vivo, since a Salmonella Lig(-) strain that has been rescued with the ATP-dependent T4 DNA ligase is less sensitive than the parental Salmonella strain. (+info)Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice. (7/650)
The aim of the present study was to determine whether alterations in 5-hydroxytryptamine (5-HT)(1A) receptors would be found in knockout mice lacking the serotonin transporter (5-HTT). Hypothermic and neuroendocrine responses to the 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT) were used to examine the function of 5-HT(1A) receptors. Initial studies evaluated the dose-response and time course of 8-OH-DPAT-induced hypothermia and hormone secretion in normal CD-1 mice (the background strain of the 5-HTT knockout mice). 8-OH-DPAT dose-dependently produced hypothermic responses that peaked at 20 min postinjection. 8-OH-DPAT-induced hypothermia was blocked by the 5-HT(1A) antagonist WAY-100635. 8-OH-DPAT dose-dependently increased the concentrations of plasma oxytocin, corticotropin, and corticosterone. In the 5-HTT knockout (-/-) mice, the hypothermic response to 8-OH-DPAT (0.1 mg/kg s.c.) was completely abolished. Furthermore, 5-HTT-/- mice had significantly attenuated plasma oxytocin and corticosterone responses to 8-OH-DPAT. No significant changes in the hypothermic or hormonal responses to 8-OH-DPAT were observed in heterozygous (5-HTT+/-) mice. [(3)H]8-OH-DPAT- and [(125)I]MPPI [4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-iodobenzamido]ethyl] pip erazine]-binding sites in the hypothalamus and [(125)I]MPPI-binding sites in the dorsal raphe were significantly decreased in 5-HTT-/- mice. The results indicate that lack of the 5-HTT is associated with a functional desensitization of 5-HT(1A) receptor responses to 8-OH-DPAT, which may be a consequence, at least in part, of the decrease in density of 5-HT(1A) receptors in the hypothalamus and dorsal raphe of 5-HTT-/- mice. (+info)Evidence that somatostatin sst2 receptors mediate striatal dopamine release. (8/650)
1 Somatostatin (SRIF) is a cyclic tetradecapeptide present in medium-sized aspiny interneurones in the rat striatum. We have previously shown that exogenous SRIF potently stimulates striatal dopamine (DA) release via a glutamate-dependent mechanism. We now report the ability of the selective sst2 receptor agonist, BIM-23027, to mimic this effect of SRIF. 2 In vivo microdialysis studies were performed in anaesthetized male Wistar rats. In most experiments, compounds were administered by retrodialysis into the striatum for 15 min periods, 90 min and 225 min after sampling commenced, with levels of neurotransmitters being measured by HPLC with electrochemical and fluorescence detection. 3 BIM-23027 (50 and 100 nM) stimulated DA release with extracellular levels increasing by up to 18 fold. 4 Prior retrodialysis of BIM-23027 (50 nM) abolished the effects of subsequent administration of SRIF (100 nM). 5 The agonist effects of both BIM-23027 and SRIF were abolished by the selective sst2 receptor antagonist, L-Tyr8-CYN-154806 (100 nM). 6 The AMPA/kainate receptor antagonist, DNQX (100 microM), abolished the agonist effects of BIM-23027 as previously shown for SRIF. 7 This study provides evidence that the sst2 receptor mediates the potent dopamine-releasing actions observed with SRIF in the rat striatum. Dopamine release evoked by both peptides appears to be mediated indirectly via a glutamatergic pathway. Other subtype-specific somatostatin receptor ligands were unable to elicit any effects and therefore we conclude that no other somatostatin receptor types are involved in mediating the dopamine-releasing actions of SRIF in the striatum. (+info)
Aminopyridines and Acetyl-DL-leucine: New Therapies in Cerebellar Disorders | Bentham Science
Rapid protium-deuterium exchange of 4-aminopyridines in neutral D2O under microwave irradiation : Sussex Research Online
Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses - 1st Edition
Top Quality 99% Amlexanox Cas:68302-57-8 - Wuhan Yuancheng Gongchuang Technology Co.Ltd - ecplaza.net
Flow Chemistry Reactions 1
3,4-Diaminopyridine, China 3,4-Diaminopyridine, 3,4-Diaminopyridine exporters, China 3,4-Diaminopyridine Suppliers - nwchemical
Flupirtine : usage, side effects, expert advice and flupirtine based medicines | 1mg
BKM120 in Cancers With PIK3CA Activating Mutations - Tabular View - ClinicalTrials.gov
Pyroxamide | CAS# 382180-17-8 | 2189 | BioVision, Inc.
Repositorio da Producao Cientifica e Intelectual da Unicamp: Caracterização dos efeitos celulares e moleculares de NVP-BKM120,...
Flupirtine reduces functional deficits and neuronal damage after global ischemia in rats, Brain Research | 10.1016/S0006-8993...
Flupirtine is an effective analgesic: is the associated rare liver injury a limiting factor to its use? - Sheffield Hallam...
Flupirtine - DrugBank
Plus it
Enhanced brain motor activity in patients with MS after a single dose of 3,4-diaminopyridine. | Harvard Catalyst Profiles |...
Real Estate Property Manager and bkm Capital Partners - SelectLeaders
Whats New | bkm OfficeWorks
Casio ur ECB-500DC-1AER Herreur
CCCC 1991, Volume 56, Issue 11, Abstracts pp. 2313-2325
| Collection of Czechoslovak Chemical Communications
Synthesis and reactivity of cationic iridium aminocarbenes derived from terminal alkynes and 2-aminopyridines | DR-NTU
Effects of roflumilast on early and late allergic response and airway hyperresponsiveness in Aspergillus fumigatus-sensitized...
3,4-diaminopyridine | definition of 3,4-diaminopyridine by Medical dictionary
Peer Evaluation : Mass Spectrometry Analysis of Isotopic Abundance of 13C,2H, or 15N in Biofield Energy Treated Aminopyridine...
Methapyrilene - Wikipedia
IUCr) 2,3-Di-amino-pyridinium sorbate-sorbic acid (1/1)
BKM120 and Fulvestrant for Treating Postmenopausal Patients With Estrogen Receptor-Positive Stage IV Breast Cancer - Full Text...
Amlexanox
AMLEXANOX - UK
Drug - Gainehair 2% /1.5% - 60ml Lotion (Diaminopyridine Oxide) Price List or Cost of Medication | Medindia
Old Asthma Drug Provides Benefits For Treating Diabetes, Obesity - Redorbit
p-MPPI | 5-HT1A antagonist | MPPI | CAS [155204-23-2] | Axon 1091 | Axon Ligand™ with |98% purity available from stock from...
TERMS & CONDITIONS || BKM SOLVENTS
Global 2-Aminopyridine Market Professional Survey Report 2016 : ReportsnReports
2-pyridin-3-ylmethoxy-benzaldehyde | VWR
British Society for Neuroendocrinology
PRIME PubMed | PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblast
Identification of Degradation Products in the Phosphodiesterase (PDE-4) Inhibitor Roflumilast Using High Resolution Mass...
Activation of rat thymocytes selectively upregulates the expression of somatostatin receptor subtype-1<...
Roflumilast: Who Is Using It and How It Affects Health Care Resource Utilization and Costs | Managed Care magazine
Amlexanox - LKT Labs
The pharmacological treatment of acquired nystagmus | Practical Neurology
Supplementary MaterialsSupplementary Shape S1 - The PDE4 inhibitor roflumilast was shown to effectively control symptoms of AR
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Global Amlexanox Market Research Report 2017 : ReportsnReports
A Phase II Study of BKM120 for Patients with Recurrent Glioblastoma and
Activated PI3K Pathway
Clinical Trials Register
ROMEMA
A Pilot Study of the PI3K Inhibitor BKM120 in Patients With Relapsed Lymphoma - AdisInsight
BKM120 + Carboplatin + Paclitaxel for Patients With Advanced Solid Tumors
Accounting Firm BKM Sowan Horan Recognized by Dallas Business Journal
Compounds, Compositions and Methods - Patent application
Signed.....bkm: the extension of Lent
CAS 209328-99-4 5-Amino-3-bromo-2-fluoropyridine - BOC Sciences
2-amino-1-pyridin-3-yl-ethanone hydrochloride CAS 93103-00-5 MDL MFCD03093361 - Labseeker
Sodium hypobromite
Allen, C. F. H.; Wolf, Calvin N. (1950). "3-Aminopyridine". Organic Syntheses. 30: 3. doi:10.15227/orgsyn.030.0003.; Collective ... such as in the synthesis of 3-aminopyridine from nicotinamide (Hofmann rearrangement). Schmeisser, M. (1963). "Sodium ...
Hofmann rearrangement
ISBN 3527306730.. Allen, C. F. H.; Wolf, Calvin N. (1950). "3-Aminopyridine". Organic Syntheses. 30: 3. doi:10.15227/orgsyn. ... In the preparation of anthranilic acid from phthalimide Nicotinic acid is converted into 3-Aminopyridine The symmetrical ...
[email protected]
6b 2-aminopyridine; 6 2-pyridoxine/2-aminopyridine; 7a Adenine; 7b Thymine; 7 Adenine/thymine WC; 8a Methane; 8 Methane dimer; ...
Amifampridine
Solari, A.; Uitdehaag, B.; Giuliani, G.; Pucci, E.; Taus, C. (2002). "Aminopyridines for symptomatic treatment in multiple ... Sedehizadeh, S; Keogh, M; Maddison, P (2012). "The use of aminopyridines in neurological disorders". Clinical Neuropharmacology ... more specifically 4-aminopyridine-3-ylammonium dihydrogen phosphate. This salt forms prismatic, monoclinic crystals (space ...
Saxitoxin
Chang, F. C.; Spriggs, D. L.; Benton, B. J.; Keller, S. A.; Capacio, B. R. (1997). "4-Aminopyridine reverses saxitoxin (STX)- ... Chen, H.; Lin, C.; Wang, T. (1996). "Effects of 4-Aminopyridine on Saxitoxin Intoxication". Toxicology and Applied Pharmacology ... Studies in animals have shown that the lethal effects of saxitoxin can be reversed with 4-aminopyridine, but there are no ... A therapeutic window for 4-aminopyridine (4-AP)". Toxicon. 36 (4): 571-588. doi:10.1016/s0041-0101(97)00158-x. PMID 9643470. ...
Betty Harris (scientist)
CS1 maint: discouraged parameter (link) Harris, Betsy Wright (1975). Reactions of 2-aminopyridine with picryl halides. ... "Reactions of 2-aminopyridine with picryl halides". After gaining her PhD, she taught chemistry and mathematics at Mississippi ...
2-Aminopiridin - Википедија, слободна енциклопедија
2-Aminopyridine. Преузето из „https://sr.wikipedia.org/w/index.php?title=2-Aminopiridin&oldid=8819418" ...
Red-winged blackbird
4-Aminopyridine is applied to one in one hundred particles of ground corn used as bait. Generally, corn is thrown into the ... The initial application of 4-aminopyridine should be carried out as soon as possible after the start of the milky stage of the ... In Brown County (Northeast South Dakota), in 1965, hand-spread 4-aminopyridine baits at intervals of about one week reduced ... Likewise, a low population density of ichterides can reduce the effectiveness of its control with 4-aminopyridine. A variety of ...
Centre for Human Reproductive Science
Gu Y, Kirkman-Brown JC, Korchev Y, Barratt CL, Publicover SJ (October 2004). "Multi-state, 4-aminopyridine-sensitive ion ...
Pyridyne
The reaction of 4-bromopyridine with sodium in liquid ammonia gives both 3-aminopyridine and 4-aminopyridine through the 3,4- ... The methylthio and amino pyridines were found to be formed in the same ratio. In 1972 Kramer and Berry inferred the formation ...
Pyridine
Here, sodium amide is used as the nucleophile yielding 2-aminopyridine. The hydride ion released in this reaction combines with ... The unsubstituted pyridine ring degrades more rapidly than picoline, lutidine, chloropyridine, or aminopyridines, and a number ...
Xylazine
Combining yohimbine and 4-aminopyridine in an effort to antagonize xylazine is superior as compared to the administration of ... Ndeereh DR, Mbithi PM, Kihurani DO (June 2001). "The reversal of xylazine hydrochloride by yohimbine and 4-aminopyridine in ... Effects of xylazine are also reversed by the analeptics 4-aminopyridine, doxapram, and caffeine, which are physiological ...
N-(p-Amylcinnamoyl)anthranilic acid
"4-Aminopyridine and the early outward current of sheep cardiac Purkinje fibers". J Gen Physiol 1979;73:139-157. Zygmunt AC, ... Li GR, Feng J, Wang Z, Fermini B, Nattel S. "Comparative mechanisms of 4-aminopyridine-resistant Ito in human and rabbit atrial ...
2-Bromopyridine
It can be prepared from 2-aminopyridine via diazotization followed by bromination. 2-Bromopyridine reacts with butyllithium to ...
4-Pyridylnicotinamide
It is synthesized through the reaction of nicotinoyl chloride and 4-aminopyridine. Gardner, T. S.; Wenis, E.; Lee, J. (1954). " ...
2-Pyridone
"Infrared studies of tautomerism in 2-hydroxypyridine 2-thiopyridine and 2-aminopyridine". Spectrochimica Acta Part A: Molecular ...
2,2'-Dipyridylamine
Alternatively, 2-aminopyridine can be heated with 2-chloropyridine over barium oxide. Wang, Suning (2001). "Luminescence and ...
Paroxysmal depolarizing shift
2010), Modulation of Nickel-Induced Bursting with 4-Aminopyridine in Leech Retzius Nerve Cells. http://serbiosoc.org.rs/arch_ ...
Nicotinamide ribonucleoside uptake transporters
"PnuC and the utilization of the nicotinamide riboside analog 3-aminopyridine in Haemophilus influenzae". Antimicrobial Agents ...
Vinpocetine
Glu release after in vivo exposure to 4-aminopyridine (4-AP) which suggests an important mechanism for vinpocetine ... "Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic ...
Mushi Santappa
"Hydrogen bonding and tautomeric equilibria in Schiff bases derived from 2-amino pyridines: electronic spectral evidence for ...
Feral pigeon
In the United States market, only 4-aminopyridine (Avitrol) and DRC-1339 remain registered by EPA. DRC-1339 is limited to USDA ...
Tetraethylammonium
"Ion dependence of the release of noradrenaline by tetraethylammonium and 4-aminopyridine from cat splenic slices." Br. J. ...
Tetrodotoxin
Chang FC, Spriggs DL, Benton BJ, Keller SA, Capacio BR (1997). "4-Aminopyridine reverses saxitoxin (STX)- and tetrodotoxin (TTX ... Haitian man allegedly buried alive under the effect of TTX 4-Aminopyridine Brevetoxin Ciguatoxin Conotoxin Domoic acid ...
Neurotoxin
"Significant Effects of 4-aminopyridine and Tetraethylammonium in the Treatment of 6-hydroxydopamine-induced Parkinson's Disease ...
KCNB1
... is also susceptible to tetraethylammonium (TEA) and 4-aminopyridine (4-AP), which completely block all channel activity. ...
Kelly Chibale
In 2012 Chibale's group discovered MMV390048, an aminopyridine compound that can be used as a single-dose treatment for malaria ...
Dizocilpine
"Late N-methyl-D-aspartate receptor blockade rescues hippocampal neurons from excitotoxic stress and death after 4-aminopyridine ...
RRM2
2008). "A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced ...
Carbon subsulfide
... the reaction of C3S2 with 2-aminopyridine. Using microwave spectroscopy, small CnS2 clusters have been detected in interstellar ...
4-aminopyridine | chemistry | Britannica
... including tetraethylammonium and 4-aminopyridine. They work by blocking potassium-selective channels in the nerve membrane, ... Other articles where 4-aminopyridine is discussed: drug: Drugs that affect skeletal muscle: …acetylcholine release, ... acetylcholine release, including tetraethylammonium and 4-aminopyridine. They work by blocking potassium-selective channels in ...
Aminopyridine - Wikipedia
2-Aminopyridine
ionization potentials of amino pyridines, Tetrahedron Lett., 1973, 3193. [all data] Steck and Ewing, 1948. Steck, E.A.; Ewing, ... Bickerton, J.; Pilcher, G.; Al-Takhin, G., Enthalpies of combustion of the three aminopyridines and the three cyanopyridines, J ... Kim, B.; Thantu, N.; Weber, P.M., High resolution photoelectron spectroscopy: The vibrational spectrum of the 2-aminopyridine ... Kobayashi, T.; Nagakura, S., Photoelectron spectra of aminopyridines and cyanopyridines, J. Electron Spectrosc. Relat. Phenom. ...
3-Aminopyridine - Wikipedia
CDC - NIOSH Pocket Guide to Chemical Hazards -
2-Aminopyridine
Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses - 1st Edition
Purchase Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses - 1st Edition. Print Book & E-Book ... Differences in Actions of 4-Aminopyridine and 4-Methyl-2-Aminopyridine. Effects of Aminopyridines in Avian Muscular Dystrophy. ... Anti-Curare Action of 4-Aminopyridine and 4-Aminopyridine-Like Substances. 4-Aminopyridine Reversal of Morphine Analgesia. 4- ... Effect of 4-Aminopyridine on the Desensitisation of the Rat Diaphragm Caused by Carbachol. The Effects of 4-Aminopyridine on ...
Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose
4-Aminopyridine (4-AP) is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS). ... A. M. King, N. B. Menke, K. D. Katz, and A. F. Pizon, "4-aminopyridine toxicity: a case report and review of the literature," ... 4-Aminopyridine (4-AP) is indicated for the improvement of walking speed and motor fatigue in multiple sclerosis (MS). An ... C. M. Stork and R. S. Hoffman, "Characterization of 4-aminopyridine in overdose," Journal of Toxicology-Clinical Toxicology, ...
METHODS OF USING SUSTAINED RELEASE AMINOPYRIDINE COMPOSITIONS - Blight, Andrew R.
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release ... 4-aminopyridine (4-AP), a mono-aminopyridine known as fampridine, has been found to reduce the potassium flow in nerve impulse ... The aminopyridine may comprise 4-aminopyridine. The sustained release matrix may include for example, ... The potassium channel blockers may include aminopyridines, for example, 4-aminopyridine, 3,4-diaminopyridine and the like, most ...
RCSB PDB - 3L38: Bace1 in complex with the aminopyridine Compound 44
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.. Malamas, M.S., Barnes, K., ... Herein, we describe the identification of the 2-aminopyridine moiety as a bioisosteric replacement of the acylguanidine moiety ... X-ray crystallographic studies indicated that the 2-aminopyridine moiety interacts directly with the catalytic aspartic acids ... Bace1 in complex with the aminopyridine Compound 44. *DOI: 10.2210/pdb3L38/pdb ...
4-Aminopyridine in Episodic Ataxia Type 2 - Full Text View - ClinicalTrials.gov
4-Aminopyridine in Episodic Ataxia Type 2 (4AP in EA2). The recruitment status of this study is unknown. The completion date ... 4-Aminopyridine (4AP) has been found to be helpful in a handful of patients with EA2. Recently, dalfampridine, an extended ... The purpose of this randomized trial is to test whether 4-aminopyridine may reduce the ataxia episodes in EA2 as an alternative ... Glasauer S, Strupp M, Kalla R, Büttner U, Brandt T. Effect of 4-aminopyridine on upbeat and downbeat nystagmus elucidates the ...
4-aminopyridine and cerebellar gait: a retrospective case series. | Sigma-Aldrich
4-aminopyridine | definition of 4-aminopyridine by Medical dictionary
4-aminopyridine explanation free. What is 4-aminopyridine? Meaning of 4-aminopyridine medical term. What does 4-aminopyridine ... Looking for online definition of 4-aminopyridine in the Medical Dictionary? ... 4-aminopyridine. Also found in: Encyclopedia, Wikipedia. 4-aminopyridine. 1. a central nervous system stimulant and a ... iberiotoxin + 4-aminopyridine +barium chloride + glibenclamide + TEA).. Cerebral vasodilator properties of Danshen and Gegen: a ...
6-aminopyridine-2-carboximidamide dihydrochloride | CAS No. 1432679-10-1 | Sigma-Aldrich
4-Aminopyridine treatment for chronic spinal cord injury
Until recently, I have been reluctant to post much about 4-aminopyridine (4-AP) or fampridine for three reasons. First, ... 4-Aminopyridine treatment for chronic spinal cord injury Dr. Young,. What is the average dosage required for 4 AP to work? I ... In summary, 4-aminopyridine or fampridine is not an innocuous drug. Nor is it a cure for spinal cord injury. In theory, it ... Until recently, I have been reluctant to post much about 4-aminopyridine (4-AP) or fampridine for three reasons. First, ...
Does 4-aminopyridine "beat" downbeat nystagmus? | Journal of Neurology, Neurosurgery & Psychiatry
Characterizing Concentration-Dependent Neural Dynamics of 4-Aminopyridine-Induced Epileptiform Activity
Similarly, IA and ID antagonist 4-aminopyridine (4AP) has been shown, in in vivo and in vitro studies, to cause ... Characterizing Concentration-Dependent Neural Dynamics of 4-Aminopyridine-Induced Epileptiform Activity. Timothy L Myers1,2, ... Galvan M, Grafe P, ten Bruggencate G (1982) Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice. ... Keywords: 4-aminopyridine; KCC2 co-transporter; Epileptiform activity; in vitro brain slices ...
Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility...
Herein we report the synthesis and evaluation of aminopyridine and aminopyrimidine analogs of SX-517 and SX-576, identifying (2 ... Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility ... Boronic Acid-Containing Aminopyridine- and Aminopyrimidinecarboxamide CXCR1/2 Antagonists: Optimization of Aqueous Solubility ... Boronic Acid-Containing Aminopyridine- and Aminopyrimidinecarboxamide CXCR1/2 Antagonists: Optimization of Aqueous Solubility ...
JCI -
Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in...
Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. ... Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. ... Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels. ... These seizures were briefer and less frequent upon coinjection of 4-aminopyridine and leptin. In mice, intranasal ...
4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine - No Study Results Posted - ClinicalTrials.gov
N-[(5-methyl-2-oxo-1-pentyl-indol-3-ylidene)amino]pyridine-3-carboxamide
... amino]pyridine-3-carboxamide
2-Aminopyridine- CAS Number 504-29-0
Exploring the Antiplasmodial 2‐Aminopyridines as Potential Antitrypanosomal Agents | Medicines for Malaria Venture
2-Aminopyridine - NO.35069
... alpha-Aminopyridine(alpha-Ayridylamine) Amino-2-pyridine CAS:504-29-0 Properties:White powder; MP: 59~60ºC; BP: 204~210ºC; FP: ... Detailed 2-Aminopyridine Description:. Name: 2-Aminopyridine. Alias:2-Pyridinamine(2-Pyridylamine). alpha-Aminopyridine(alpha- ... Our company is specialized exporter, manufacturer and supplier of 2-Aminopyridine in China. ... 2-Aminopyridine. Home / Health & Beauty / Pharmaceutical Chemical / 2-Aminopyridine @import url(http://www.google.com/cse/api/ ...
462-08-8 - 3-Aminopyridine, 99% - 3-Pyridinamine - 3-Pyridylamine - A13216 - Alfa Aesar
Aminopyridine is used as a monomer for polymerization. It is also used in the Production of cationic dyes and Apa amoxicillin ... An efficient and cost-effective synthesis of 2-phenyl-3-aminopyridine Org. Proc. Res. Dev.2001, 5,(3), 254-256. ... RA Finch, MC Liu, SP Grill, WC Rose, R LoomisTriapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone): a potent inhibitor ...
New Proton-Sponge-Like Macrocyclic Compound: Synergistic Hydrogen Bonds of Aminopyridine - Kanbara - 2006 - European Journal of...
High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients. - Full Text View - ClinicalTrials.gov
The 4-aminopyridine will be administered in the form of gelatin capsules containing 4-aminopyridine 10 mg and microcrystalline ... High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients.. The safety and scientific validity ... Drug: 4-Aminopyridine Each patient will take 10 mg per kilogram of weight (example: a person weighing 60 kg, will take two ... 4-Aminopyridine and spinal cord injury: a review. Restor Neurol Neurosci. 1994 Jan 1;6(4):259-70. doi: 10.3233/RNN-1994-6401. ...
CAS No.289483-92-7,6-Aminopyridine-3-sulfonyl chloride Suppliers
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Aminopyridines and Acetyl-DL-leucine: New Therapies in Cerebellar Disorders | Bentham Science
Keywords: Cerebellar ataxia, central vestibular disorders, aminopyridines, 4-aminopyridine, episodic ataxia type 2, downbeat ... Keywords:Cerebellar ataxia, central vestibular disorders, aminopyridines, 4-aminopyridine, episodic ataxia type 2, downbeat ... Aminopyridines and Acetyl-DL-leucine: New Therapies in Cerebellar Disorders. Author(s): Roger Kalla, Department of Neurology, ... Alviña, K.; Khodakhah, K. The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia. J. Neurosci., 2010, 30(21), ...
Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia
3-aminopyridine-2-carboxaldehyde thiosemicarbazone interacts with iron II. *. 3-aminopyridine-2-carboxaldehyde ... Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia. Charles A Kunos,* Tomas ... Indications of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone sequelae attributable to methemoglobinemia include resting ... Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose ...
Effects of 4-AminopyridineFampridinePyridineAcetylcholine releaseAntagonistsNitric Oxide SyEpisodicCompoundsSynaptic TransmissionAmpyraDownbeat nystagmusDerivatives of formulaSynthesisCerebellarSuppliers2016InhibitionInhibitor2018Multiple sclerosisVivoEfficacy and safetyThiosemicarbazoneChannel blockerRestoresAvitrolHighly-selectiveAcidsNeurologicalSpinalVoltage-gatedPhaseInducibleGlibenclamideCardiac musclePharmacokineticsInvention relatesChronicExperimentalHippocampusCurrentsMoleculesCompositionPlacebo-controlled
Effects of 4-Aminopyridine3
- Differential effects of 4-aminopyridine on acetylcholine release triggered by [K. (thefreedictionary.com)
- The effects of 4-aminopyridine (4AP) on the extracellularly recorded nerve terminal action potential (NTAP) and end-plate potential were studied at the frog neuromuscular junction. (aspetjournals.org)
- An assessment of the effects of 4-aminopyridine (4-AP) on xylazine-induced sedation in goats was done. (ac.ke)
Fampridine7
- Aminopyridine may refer to any of several chemical compounds: 2-Aminopyridine 3-Aminopyridine 4-Aminopyridine (4-AP), also known as fampridine or dalfampridine This set index page lists chemical compounds articles associated with the same name. (wikipedia.org)
- 4-aminopyridine (4-AP), a mono-aminopyridine known as fampridine, has been found to reduce the potassium flow in nerve impulse transmission and, thereby, shows effectiveness in restoring conduction in blocked and demyelinated nerves. (freepatentsonline.com)
- Acorda Therapeutics (Hawthorne, NY) announced preliminary results of a phase II clinical trial of Fampridine-SR, an oral, sustained-release formula of 4-aminopyridine , to treat MS symptoms. (thefreedictionary.com)
- Until recently, I have been reluctant to post much about 4-aminopyridine (4-AP) or fampridine for three reasons. (rutgers.edu)
- Fampridine or 4-aminopyridine is a broad-spectrum blocker of the Kv1 family of voltage-gated potassium channels that is used as a symptomatic therapy for patients with certain neuromuscular disorders to enhance synaptic neuronal conduction (1). (thefreedictionary.com)
- tell your doctor and pharmacist if you are allergic to dalfampridine, 4-aminopyridine (4-AP, fampridine) that has been prepared by your pharmacist, any other medications, or any of the ingredients in dalfampridine tablets. (medlineplus.gov)
- Be sure to mention any other form of 4-aminopyridine (4-AP, fampridine) that has been prepared by your pharmacist. (medlineplus.gov)
Pyridine1
- Spectroscopic results indicate that sorbed aminopyridine molecules onto loughlinite are coordinated to Lewis acidic centers, zeolitic/bound water molecules, and surface silanol groups by hydrogen bonding interaction through pyridine ring nitrogen lone pairs. (iku.edu.tr)
Acetylcholine release1
- acetylcholine release, including tetraethylammonium and 4-aminopyridine . (britannica.com)
Antagonists3
- Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailabil. (nih.gov)
- Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability. (nih.gov)
- EFFECT: 2-aminopyridine derivatives as adenosine receptor antagonists useful in medicine. (russianpatents.com)
Nitric Oxide Sy1
- 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. (scripps.edu)
Episodic1
- This study aims to determine whether 4-aminopyridine (4AP) can reduce attacks of ataxia in patients with episodic ataxia type 2 (EA2), a rare but often debilitating condition. (clinicaltrials.gov)
Compounds3
- The clinical applications of aminopyridines and further miscellaneous actions of aminopyridines and related compounds are also considered. (elsevier.com)
- The QSAR model derived for the former suggested that nNOS inhibition activity of the compounds is basically controlled by electronic nature of the molecule and that the compounds having fused ring would have added advantage and the one derived for the latter suggested that iNOS inhibition activity of 2-aminopyridines is controlled by hydrophobic nature of 6-substituents and the steric nature of 4-substituents. (ovid.com)
- The scientific purposes of aminopyridines and additional miscellaneous activities of aminopyridines and similar compounds also are considered. (u1-frisuren.de)
Synaptic Transmission1
- 4-Aminopyridine (4AP) increases evoked excitatory as well as inhibitory synaptic transmission in the spinal cord (Brain Research, 240 (1982) 117), enhances interneuronal spontaneous activity and partly restores impaired spinal cord functions (Neuroscience, 126 (2004) 511). (edu.mx)
Ampyra1
- Except for subject A, who had been taking 4-aminopyridine (Ampyra[R]) for 5 years at the time of enrollment, none were on neuromodulatory medication (e.g., baclofen). (thefreedictionary.com)
Downbeat nystagmus2
- Does 4-aminopyridine "beat" downbeat nystagmus? (bmj.com)
- As a current key-therapy for the treatment of downbeat nystagmus 4-aminopyridine (4-AP) is suggested for the treatment of downbeat nystagmus (5-10 mg Twice a day [TID]), a frequent type of persisting nystagmus, due to a compromise of the vestibulo-cerebellum. (eurekaselect.com)
Derivatives of formula1
- The invention relates to novel aminopyridine derivatives of formula (I) wherein R1 is methyl an R 4 and amino group - NR 6 R 7 and R 5 forms an arylalkynyl- or heteroarylalkynyl-group. (epo.org)
Synthesis5
- 3-Aminopyridine is prepared by heating nicotinamide with sodium hypobromite which is in turn prepared in situ by the reaction of sodium hydroxide and bromine at 70 °C. It can be used in the synthesis of organic ligand 3-pyridylnicotinamide. (wikipedia.org)
- Herein we report the synthesis and evaluation of aminopyridine and aminopyrimidine analogs of SX-517 and SX-576, identifying (2-{(benzyl)[(5-boronic acid-2-pyridyl)methyl]amino}-5-pyrimidinyl)(4-fluorophenylamino)formaldehyde as a potent chemokine antagonist with improved aqueous solubility and oral bioavailability. (nih.gov)
- In this paper we propose the synthesis of 1-(2-aminopyridine)-4-phenyl-1-azabuta-1,3-diene and 1-(3-aminopyridine)-4-phenyl-1-azabuta-1,3-diene as new heterodienes for iron carbonyl complexes. (mdpi.com)
- Ethyl 2-aminopyridine-4-carboxylate is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields. (fishersci.dk)
- This method contrasts and complements acid-mediated H/D exchange, requires no catalyst and is appropriate for the synthesis of deuterium isotop-ologues of N- and C-substituted 4-aminopyridines and a ben-zofused (quinoline) analogue. (sussex.ac.uk)
Cerebellar3
- 4-aminopyridine and cerebellar gait: a retrospective case series. (sigmaaldrich.com)
- Aminopyridines have been demonstrated viable for the symptomatic treatment of certain forms of cerebellar ataxia. (eurekaselect.com)
- The role of small-conductance Ca2+-activated K+ channels in the modulation of 4-aminopyridine-induced burst firing in rat cerebellar Purkinje cells. (abcam.cn)
Suppliers1
- It captures 4-aminopyridine-2,6-dicarboxylic acid market trends, pays close attention to 4-aminopyridine-2,6-dicarboxylic acid manufacturers and names suppliers. (marketpublishers.com)
20162
- The report then estimates 2016-2021 market development trends of 2-Aminopyridine (CAS 504-29-0) industry. (reportsnreports.com)
- 2016. Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance. (lshtm.ac.uk)
Inhibition1
- Inhibition by 4-aminopyridine (4-AP) of K DR of rabbit portal vein (RPV) myocytes was studied by patch clamp and compared with that of channels composed of Kv1.5 and/or Kv1.2 subunits cloned from the RPV and expressed in mammalian cells. (ahajournals.org)
Inhibitor3
- Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels. (jci.org)
- RA Finch, MC Liu, SP Grill, WC Rose, R LoomisTriapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone): a potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity. (alfa.com)
- The anticancer agent 3-aminopyridine-2-carboxaldehyde thiosemicarbazone is a ribonucleotide reductase inhibitor. (pubmedcentralcanada.ca)
20183
- 4-Aminopyridine-2,6-Dicarboxylic Acid (CAS 2683-49-0) Market Research Report 2018 aims at providing comprehensive data on 4-aminopyridine-2,6-dicarboxylic acid market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
- 4-Aminopyridine-2,6-Dicarboxylic Acid (CAS 2683-49-0) Market Research Report 2018 contents were prepared and placed on the website in January, 2018. (marketpublishers.com)
- Please note that 4-Aminopyridine-2,6-Dicarboxylic Acid (CAS 2683-49-0) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
Multiple sclerosis4
- 4-Aminopyridine (4-AP) is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS). Medication error can occur, as commercial preparation may not be available in some countries. (hindawi.com)
- 4-Aminopyridine (4-AP) is indicated for the improvement of walking speed and motor fatigue in multiple sclerosis (MS). An overdose in 4-AP can produce detrimental side effects. (hindawi.com)
- Aminopyridines are used as a drug for symptomatic treatment of multiple sclerosis by blocking potassium channels and prolonging action potentials [8, 9]. (trivedieffect.com)
- channels by the multiple sclerosis drug 4-aminopyridine ," Journal of Biological Chemistry, vol. (thefreedictionary.com)
Vivo2
- Similarly, IA and ID antagonist 4-aminopyridine (4AP) has been shown, in in vivo and in vitro studies, to cause hyperexcitability and the development of seizure-like epileptiform discharges [ 15 - 23 ]. (omicsonline.org)
- Tapia, "Paired pulse facilitation is turned into paired pulse depression in hippocampal slices after epilepsy induced by 4-aminopyridine in vivo," Neuropharmacology, vol. (thefreedictionary.com)
Efficacy and safety2
- This randomized, double-blind, placebo-controlled study examined the efficacy and safety of 4-aminopyridine (4-AP). (thefreedictionary.com)
- After the follow-up period, all test results will be analyzed and compared to determine the efficacy and safety of 4-aminopyridine. (clinicaltrials.gov)
Thiosemicarbazone3
- Unfortunately, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone also alters iron II (Fe 2+ ) in hemoglobin. (pubmedcentralcanada.ca)
- This balance may be perturbed by symptomatic toxicity levels during 3-aminopyridine-2-carboxaldehyde thiosemicarbazone therapy. (pubmedcentralcanada.ca)
- Indications of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone sequelae attributable to methemoglobinemia include resting dyspnea, headaches and altered cognition. (pubmedcentralcanada.ca)
Channel blocker2
- The K + channel blocker, 4-aminopyridine (4-AP), was used as neuronal stimulant. (deepdyve.com)
- We examined 4-aminopyridine (4-AP), a potassium-channel blocker as a possible treatment for TPI. (elsevier.com)
Restores2
- The drug 4-aminopyridine partially restores some sensory and motor functions in one-third of patients who have been paralyzed for months to years. (thefreedictionary.com)
- 4-Aminopyridine restores fract. (edu.mx)
Avitrol1
- Most common chemicals that are used as avicides are DRC-1339 (chemically known as 3-chloro-4-methylaniline hydrochloride or starling), CPTH (3-chloro-p-toluidine), Avitrol ( 4-aminopyridine ) and Chloralose among others. (thefreedictionary.com)
Highly-selective1
- 4-Aminopyridines undergo surprisingly rapid and highly-selective H/D exchange at C-2 and C-6 in neutral D2O upon microwave irradiation at only 190 °C for 2 h in a sealed vessel. (sussex.ac.uk)
Acids2
- X-ray crystallographic studies indicated that the 2-aminopyridine moiety interacts directly with the catalytic aspartic acids Asp32 and Asp228 via a hydrogen-bonding network. (rcsb.org)
- 2-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. (chemicalbook.com)
Neurological1
- One sub-class of potassium channel blockers, aminopyridines have shown promise in the treatment of neurological diseases. (freepatentsonline.com)
Spinal1
- High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients. (clinicaltrials.gov)
Voltage-gated1
- 4-Aminopyridine (4-AP) is widely used to selectively inhibit voltage-gated K + channels (Kv) and to identify their role(s) in control of vascular smooth muscle (VSM) tone. (ahajournals.org)
Phase1
- In this article, retention modeling of eight aminopyridines (synthesized and characterized at the Faculty of Pharmacy) in reversed-phase high performance liquid chromatography (RP-HPLC) was performed. (ac.rs)
Inducible1
- A series of imidazoles and some mono or bicyclic nitrogen-containing heterocycles was reported to potently act against neuronal NOS (nNOS) and a series of 2-aminopyridines to act against inducible NOS (iNOS). (ovid.com)
Glibenclamide2
- iberiotoxin + 4-aminopyridine +barium chloride + glibenclamide + TEA). (thefreedictionary.com)
- This solution contains 10 mM tetraethyl ammonium (TEA), 3 mM 4-aminopyridine (4-AP), 50 nM charybdotoxin, 10 mM glibenclamide (Glib), and 100 nM apamin. (thefreedictionary.com)
Cardiac muscle2
- and the effects of aminopyridines on the skeletal, smooth and cardiac muscle. (elsevier.com)
- and the results of aminopyridines at the skeletal, delicate and cardiac muscle. (u1-frisuren.de)
Pharmacokinetics2
- 1. A method of establishing steady state plasma pharmacokinetics of 4-aminopyridine, said method comprising administering sustained release 4-aminopyridine, as set forth herein. (freepatentsonline.com)
- 2. The method of claim 1 further comprising a step of maintaining the steady state plasma pharmacokinetics of 4-aminopyridine. (freepatentsonline.com)
Invention relates1
- The present invention relates to a new connection, 2-aminopyridine, the method of its production and use as a medicine. (russianpatents.com)
Chronic1
- NRI), a biopharmaceutical company focused on treatments for peripheral neuropathies, has announced that its request for orphan drug designation of 4-Aminopyridine has been granted for treatment of chronic functional motor and sensory deficits resulting from Guillain-Barre Syndrome (GBS). (thefreedictionary.com)
Experimental2
- In addition, an experimental drug, 4-aminopyridine , appears to increase the velocity of impulses in demyelinated nerves. (thefreedictionary.com)
- Ab initio calculations reveal that radiative lifetime of the lowest excited singlet state of 2-aminopyridine (2AP) molecule should be around 20 ns , consistent with the molecules of the same type, but is about one order of magnitude larger than the claimed experimental fluorescent lifetime in recent years. (diva-portal.org)
Hippocampus1
- Avoli M, Psarrapoulou C, Tancredi V, Fueta Y (1993) On the synchronous activity induced by 4-aminopyridine in the CA3 subfield of juvenile rat hippocampus. (springer.com)
Currents1
- KA) channel currents, which are highly sensitive to 4-aminopyridine , and slowly inactivated or noninactivated currents such as delayed rectifying [K.sup. (thefreedictionary.com)
Molecules1
- The aminopyridines, selected for this study are heterocyclic pharmacophores for many bioactive small organic molecules [5]. (trivedieffect.com)
Composition1
- andwherein the 4-aminopyridine is less than 5% by weight of the composition. (patentsencyclopedia.com)
Placebo-controlled1
- Three randomized, placebo-controlled trials for 4-Aminopyridine all employed the Ashworth measure of spasticity but none of the studies were specifically designed to study spasticity (Donovan et al. (scireproject.com)