Aminopropionitrile: Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.Metabolome: The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Guanosine Diphosphate Fucose: A nucleoside diphosphate sugar formed from GDPmannose, which provides fucose for lipopolysaccharides of bacterial cell walls, and for blood group substances and other glycoproteins.Guanosine Diphosphate Sugars: Esters formed between the aldehydic carbon of sugars and the terminal phosphate of guanosine diphosphate.Guanosine Diphosphate Mannose: A nucleoside diphosphate sugar which can be converted to the deoxy sugar GDPfucose, which provides fucose for lipopolysaccharides of bacterial cell walls. Also acts as mannose donor for glycolipid synthesis.Prostatic Intraepithelial Neoplasia: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Hydro-Lyases: Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.Allylamine: Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.SemicarbazidesNecrosis: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.Aorta: The main trunk of the systemic arteries.Tunica Media: The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Procollagen: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase: A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)Cell Wall: The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.Cystatin C: An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.Procollagen-Proline Dioxygenase: A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.Hydroxylysine: A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens.Son of Sevenless Protein, Drosophila: A guanine nucleotide exchange factor from DROSOPHILA. Sevenless refers to genetic mutations in DROSOPHILA that cause loss of the R7 photoreceptor which is required to see UV light.gamma-Glutamyltransferase: An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Glycylglycine: The simplest of all peptides. It functions as a gamma-glutamyl acceptor.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Proplast: Polymer of polytetrafluoroethylene and carbon filaments; porous biocompatible material used in orofacial and middle ear reconstruction and as coating for metal implants.Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Enophthalmos: Recession of the eyeball into the orbit.Polytetrafluoroethylene: Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.Ear, Middle: The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.Prostheses and Implants: Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.Tantalum: Tantalum. A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices. (Dorland, 28th ed)MercaptoethylaminesPatents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Wound Healing: Restoration of integrity to traumatized tissue.Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.Atrial Remodeling: Long-term changes in the electrophysiological parameters and/or anatomical structures of the HEART ATRIA that result from prolonged changes in atrial rate, often associated with ATRIAL FIBRILLATION or long periods of intense EXERCISE.Cicatrix: The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Stereognosis: Perception of shape and form of objects by TOUCH, via tactile stimuli.Amino Alcohols: Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).EstersAmino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Lactams: Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.Diamines: Organic chemicals which have two amino groups in an aliphatic chain.Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Stearates: Salts and esters of the 18-carbon saturated, monocarboxylic acid--stearic acid.Myristates: Salts and esters of the 14-carbon saturated monocarboxylic acid--myristic acid.Acrylamide: A colorless, odorless, highly water soluble vinyl monomer formed from the hydration of acrylonitrile. It is primarily used in research laboratories for electrophoresis, chromatography, and electron microscopy and in the sewage and wastewater treatment industries.Gels: Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.Acrylamides: Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.Eichhornia: A plant genus of the family PONTEDERIACEAE that is used as a biological filter for treating wastewater.Porosity: Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Hydrogels: Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)Selection, Genetic: Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.Idiopathic Pulmonary Fibrosis: A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).Elasticity Imaging Techniques: Non-invasive imaging methods based on the mechanical response of an object to a vibrational or impulsive force. It is used for determining the viscoelastic properties of tissue, and thereby differentiating soft from hard inclusions in tissue such as microcalcifications, and some cancer lesions. Most techniques use ultrasound to create the images - eliciting the response with an ultrasonic radiation force and/or recording displacements of the tissue by Doppler ultrasonography.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Contrast Media: Substances used to allow enhanced visualization of tissues.Hepatic Stellate Cells: Perisinusoidal cells of the liver, located in the space of Disse between HEPATOCYTES and sinusoidal endothelial cells.Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

The smooth muscle cell. III. Elastin synthesis in arterial smooth muscle cell culture. (1/87)

Primate arterial smooth muscle cells and skin fibroblasts were examined for their ability to synthesize elastin in culture. In the presence of the lathyrogen beta-aminopropionitrile, the smooth muscle cells incorporate [3H]lysine into a lysyl oxidase substrate that was present in the medium and associated with the cell layer. A component having a mol wt of 72,000 and an electrophoretic mobility similar to that of authentic tropoelastin was isolated from the labeled smooth muscle cells by coacervation and fractionation with organic solvents. In the absence of beta-aminopropionitrile, long-term cultures of smooth muscle cells incorporated [14C]lysine into desmosine and isodesmosine, the cross-link amino acids unique to elastin. In contrast, no desmosine formation occurred in the fibroblast cultures. These characteristics demonstrate that arterial smooth muscle cells are capable of synthesizing both soluble and cross-lined elastin in culture.  (+info)

Lysyl oxidase activates the transcription activity of human collagene III promoter. Possible involvement of Ku antigen. (2/87)

Lysyl oxidase is an extracellular enzyme that controls the maturation of collagen and elastin. Lysyl oxidase and collagen III often show similar expression patterns in fibrotic tissues. Therefore, we investigated the influence of lysyl oxidase overexpression on the promoter activity of human COL3A1 gene. Our results showed that when COS-7 cells overexpressed the mature form of lysyl oxidase, the activity of the human COL3A1 promoter was increased up to an average of 12 times when tested by luciferase reporter assay. The effect was specific, because other promoters were not affected. Moreover, lysyl oxidase effect was abolished by beta-aminopropionitrile, a specific inhibitor of its catalytic activity. Electrophoretic mobility shift assay showed a binding activity in the region from -101 to -77 that was significantly increased by lysyl oxidase overexpression. The binding was specifically competed by the cold probe, and the mutagenesis of this region abolished both the binding activity in gel retardation and lysyl oxidase stimulation of COL3A1 promoter in transfection experiments. We identified the binding activity as Ku antigen in its two components: Ku80 and Ku70. This study suggests a new coordinated mechanism by which lysyl oxidase might control the development of fibrosis.  (+info)

Collagen synthesis in capsules surrounding dimethylbenzanthracene-induced rat breast tumors and the effect of pretreatment with beta-aminopropionitrile. (3/87)

Collagen synthesis is increased over three-fold in capsules surrounding dimethylbenzanthracene-induced rat breast tumors compared to the tumor parenchyma and over six-fold compared to normal breast connective tissue. Increased collagen synthesis is independent of the rate of tumor growth and final tumor size. Pretreatment of animals with beta-aminopropionitrile to inhibit collagen cross-linking caused an 82% decrease in tumor formation and a significant reduction in tumor volume (approximately 0.4 cu cm) compared to controls (approximately 10 cu cm). The four small tumors that did develop in the lathyritic animals had increased collagen synthesis in the interior tumor stroma and reduced collagen synthesis in the tumor capsule. These findings suggest that the collagenous capsule surrounding dimethylbenzanthracene tumors functions as a physical barrier to protect the tumor from the immune system of the host. The apparent antitumor effects of beta-aminopropionitrile may be due to immunopotentiation and/or cytotoxic actions of the drug.  (+info)

Analysis of the combined osteolathyritic effects of beta-aminopropionitrile and diethyldithiocarbamate on xenopus development. (4/87)

In order to examine the mechanistic basis between combined effects and mechanisms of action, two osteolathyrogens, beta-aminopropionitrile (betaAPN) and diethyldithiocarbamate (DTC), were tested together on Xenopus embryos. In a separate test, DTC was also tested with copper sulfate to determine the importance of copper in DTC-induced osteolathyrism. Frog embryos (Xenopus laevis) were exposed for 96 h, with daily solution removal and replacement. Preserved tadpoles were evaluated for osteolathyritic lesions. For the betaAPN:DTC test, a 1.2-factor matrix design was used, producing two single chemical and seven mixture-response curves. The chi(2) goodness-of-fit test was used to compare the experimental mixture-response curves with theoretical effects for two combined effects models, dose-addition and independence. All seven mixture curves were consistent with expected results for dose-addition, but the correlations were generally not high. For the DTC:copper test, the three mixture-response curves generated showed that added copper increased the DTC-alone EC(50), but there was no corresponding right shift at the top of the response curves, as observed previously with betaAPN and copper. In the betaAPN:DTC and DTC:copper tests, DTC alone showed a biphasic concentration-osteolathyrism curve, and the slope of the response curve for DTC alone in each test was statistically different than the slope for the betaAPN alone response curve. Taken together, the results suggest the potential for a second osteolathyritic effect of DTC that affected the combined toxicity enough to produce a dose-addition correlation without the chemicals necessarily having the same mechanism.  (+info)

Amine oxidase-like activity of polyphenols. Mechanism and properties. (5/87)

Polyphenols in several oxidation systems gained amine oxidase-like activity, probably due to the formation of the corresponding quinones. In the presence of Cu(II), o- and p-phenolic compounds exhibited amine oxidase-like activity, whereas only the o-phenolic compounds showed the activity in the presence of 1,1-diphenyl-2-picrylhydrazyl radical. The activity was determined by measuring the conversion of benzylamine to benzaldehyde by HPLC. Moreover, gallic acid, chlorogenic acid, and caffeic acid, which are plant polyphenols, converted the lysine residue of bovine serum albumin to alpha-amino-adipic semialdehyde residue, indicating lysyl oxidase-like activity. We also characterized the activity of pyrocatechol, hydroquinone, and pyrogallol in the presence of Cu(II). The oxidative deamination was accelerated at a higher pH, and required O2 and transition metal ions. Furthermore, EDTA markedly inhibited the reaction but not beta-aminopropionitrile, which is a specific inhibitor of lysyl oxidase. Catalase significantly inhibited the oxidation, implying the participation of hydroxyl radical in the reaction, but superoxide dismutase stimulated the oxidation, probably due to its radical formation activity. We discussed the mechanism of the oxidative deamination by polyphenols and the possible significance of the activity for biological systems.  (+info)

The effect of beta aminoproprionitrile (BAPN) on experimental amyloidosis. (6/87)

Experimental amyloidosis was induced in mice with repeated injections of complete Freund's adjuvant (CFA) reinforced with bacterial vaccine. BAPN administered in a mixture with CFA or on its own before the injection of CFA reduced the incidence of amyloidosis. The reduction in the incidence of amyloidosis following the administration of BAPN may be due to its inhibitory effect on the oxidative deamination of amino acids, which presumably inhibit cross-linking of amyloid fibrils or interfere with metabolic pathways which involve the formations of mucopolysaccharide formation. It is suggested that the defective formation of the mucopolysaccharide-amyloid protein complex inhibits amyloid deposition and induces the activity of beta glucuronidase observed in the present study. The reduced incidence of amyloidosis following BAPN adminsitration cannot be due to lysosomal enzyme degradation of the amyloid as the activity of cathepsin D and acid phosphatase is decreased during this process.  (+info)

A molecular role for lysyl oxidase in breast cancer invasion. (7/87)

We identified previously an up-regulation in lysyl oxidase (LOX) expression,an extracellular matrix remodeling enzyme, in a highly invasive/metastatic human breast cancer cell line, MDA-MB-231, compared with MCF-7, a poorly invasive/nonmetastatic breast cancer cell line. In this study, we demonstrate that the mRNA expression of LOX and other LOX family members [lysyl oxidase-like (LOXL), LOXL2, LOXL3, and LOXL4] was observed only in breast cancer cells with a highly invasive/metastatic phenotype but not in poorly invasive/nonmetastatic breast cancer cells. LOX and LOXL2 showed the strongest association with invasive potential in both highly invasive/metastatic breast cancer cell lines tested (MDA-MB-231 and Hs578T). To determine whether LOX is directly involved in breast cancer invasion, LOX antisense oligonucleotides were transfected into MDA-MB-231 and Hs578T cells, and found to inhibit invasion through a collagen IV/laminin/gelatin matrix in vitro compared with LOX sense oligonucleotide-treated and untreated controls. In addition, treatment of MDA-MB-231 and Hs578T cells with beta-aminopropionitrile (an irreversible inhibitor of LOX enzymatic activity) decreased invasive activity. Conversely, MCF-7 cells transfected with the murine LOX gene demonstrated a 2-fold increase in invasiveness that was reversible by the addition of beta-aminopropionitrile in a dose-dependent manner. In addition, endogenous LOX mRNA expression was induced when MCF-7 cells were cultured in the presence of fibroblast conditioned medium or conditioned matrix, suggesting a role for stromal fibroblasts in LOX regulation in breast cancer cells. Moreover, the correlation of LOX up-regulation and invasive/metastatic potential was additionally demonstrated in rat prostatic tumor cell lines, and human cutaneous and uveal melanoma cell lines. These results provide substantial new evidence that LOX is involved in cancer cell invasion.  (+info)

An angiotensin-converting enzyme inhibitor, not an angiotensin II type-1 receptor blocker, prevents beta-aminopropionitrile monofumarate-induced aortic dissection in rats. (8/87)

OBJECTIVE: Cystic medial degeneration (CMD) is a histologic abnormality that is common in aortic diseases such as aortic dilation, aneurysm, or dissection. Although little is known about the mechanism underlying CMD, we have previously demonstrated that angiotensin II signaling via angiotensin II type 2 receptor (AT2R) plays a central role in apoptosis of vascular smooth muscle cells (VSMCs) occurring in CMD associated with Marfan syndrome. The aim of this study is to elucidate the role of angiotensin II signaling in THE pathogenesis of aortic diseases associated with CMD. METHOD: We investigated the effects of angiotensin-converting enzyme inhibitor (ACEI), temocapril (n = 15), angiotensin II receptor type-1 (AT1R) blocker, CS-866 (n = 15), and vehicle control (n = 17) on 0.25% beta-aminopropionitrile monofumarate (BAPN)-induced aortic dissection and histopathologic findings in a rat model. RESULTS: Temocapril significantly prevented aortic dissection (P <.05), CMD (P <.01), and VSMC apoptosis (P <.01) compared with vehicle control in BAPN-fed rats. However, CS-866 did not show any preventive effect. Reversed transcriptase-polymerase chain reaction demonstrated that expression of both AT1R and AT2R was detected in control rat aortas, and that AT2R expression was significantly upregulated in the aortas of BAPN-fed rats (P <.01). Blood pressure was significantly and equally lowered in both temocapril and CS-866 groups compared with control. CONCLUSIONS: Differential expression of angiotensin II receptors and AT2R signaling are involved in the pathogenesis of CMD and aortic dissection in BAPN-fed rats. ACEIs might be of clinical value for the prevention and treatment of aortic diseases related to CMD.  (+info)

*Aminopropionitrile

... , also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional ... Beta-amino-propionitrile (BAPN) found in lathyrus odoratus (common garden sweet pea) is thought to be responsible for ... Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile. Kashin-Beck disease Lysyl oxidase Marfan syndrome ... "Aminopropionitrile - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. ...

*1,3-Diaminopropane

It is prepared by the amination of acrylonitrile followed by hydrogenation of the resulting aminopropionitrile. The potassium ...

*C3H6N2

... may refer to: Compounds sharing the molecular formula: Aminopropionitrile Dihydroimidazol-2-ylidene Imidazolines 2- ...

*Angiolathyrism

The main chemical responsible is β-Aminopropionitrile, which prevents collagen cross-linking, thus making the blood vessel, ...

*Osteolathyrism

The most widely-studied of these compounds is beta-aminopropionitrile (BAPN), which exerts its deleterious effect by an unknown ...

*Sweet pea

Seeds of the sweet pea contain beta-aminopropionitrile that prevents the cross-linking of collagen by inhibiting lysyl oxidase ...

*ATC code M01

... combinations QM01AX90 Pentosan polysulfate QM01AX91 Aminopropionitrile QM01AX92 Grapiprant QM01AX99 Combinations M01BA01 ...

*Controlled Drugs and Substances Act

... amino]propionitrile) and any salt thereof Mefenorex (d,l-N-(3-chloropropyl)-α-methylbenzeneethanamine) and any salt thereof ...

*Lysyl oxidase

... lysyl oxidase was inhibited either by nutritional copper-deficiency or by supplementation of diets with β-aminopropionitrile ( ...
Sigma-Aldrich offers abstracts and full-text articles by [Hirotaka Nagashima, Kento Uto, Yasunari Sakomura, Yoshikazu Aoka, Akiko Sakuta, Shigeyuki Aomi, Nobuhisa Hagiwara, Masatoshi Kawana, Hiroshi Kasanuki].
ß-aminopropionitrile投与による鶏胚骨格異常の解析ß-aminopropionitrile投与による鶏胚骨格異常の解析 ...
Administration of an antifibrotic agent as an adjunct to antihelmintic treatment with the objective of morbidity reduction was investigated in the murine schistosomiasis mansoni model. Antifibrotic, beta-aminopropionitrile treatment has a profound effect on the cellular matrix composition of the liver granuloma of Schistosoma mansoni infected mice when given alone, resulting in increase macrophage infiltration. These macrophages, in response to stimulation with soluble egg antigen or lipopolysaccharide produced elevated levels of nitric oxide but low levels of tumor necrosis factor alpha compared to untreated infected mice. This also correlated with reduced liver granuloma size. In spite of low numbers of eggs in the liver, mice receiving a combine treatment had a high level of resistance to a challenge infection compared with mice receiving only praziquantel. Those mice also exhibited a reduced lymphocyte proliferative response, similar to that of infected untreated mice. Antifibrotic treatment ...
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
TY - JOUR. T1 - Effects of induction and inhibition of matrix cross-linking on remodeling of the aqueous outflow resistance by ocular trabecular meshwork cells. AU - Yang, Yong Feng. AU - Sun, Ying Ying. AU - Acott, Ted. AU - Keller, Kate. PY - 2016/7/28. Y1 - 2016/7/28. N2 - The trabecular meshwork (TM) tissue controls drainage of aqueous humor from the anterior chamber of the eye primarily by regulating extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs). Glaucomatous TM tissue is stiffer than age-matched controls, which may be due to alterations in ECM cross-linking. In this study, we used genipin or beta-Aminopropionitrile (BAPN) agents to induce or inhibit matrix cross-linking, respectively, to investigate the effects on outflow resistance and ECM remodeling. Treatment with BAPN increased outflow rates in perfused human and porcine anterior segments, whereas genipin reduced outflow. Using a fluorogenic peptide assay, MMP activity was increased with BAPN treatment, but ...
TY - JOUR. T1 - Allylamine and β-aminopropionitrile induced aortic medial necrosis. T2 - Mechanisms of synergism. AU - Kumar, D.. AU - Trent, M. B.. AU - Boor, P. J.. PY - 1998/2/6. Y1 - 1998/2/6. N2 - We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. Either toxin given alone does not cause aortic lesions. In order to shed light on the mechanism of the synergistic action of these two toxins we fed known modulators of AA or βAPN toxicity to rats concurrently with the two toxins. As modulators we used (a) semicarbazide (98 mg/kg/day, given 4 h prior to toxins), a known inhibitor of the vascular enzyme SSAO which metabolizes AA (b) L-cysteine (1.5% in rat chow, beginning 3 days prior to toxins), which has been shown to reduce the toxic effects of βAPN; and (c) phenelzine sulphate (3 mg/kg/day, given 4 h prior to toxins), an inhibitor of ...
In normal and lathyritic chick embryos bone collagen was synthesized primarily in the periosteum of the femurs, and was organized as radioactive spicules in these bones. Saline extraction of the lathyritic bones removed the radioactive spicules, although they eventually seemed to become non-extractable. Normal bone seemed to be unaffected by saline extraction. Marked variation in the degree of isotope incorporation was seen in collagenous and non-collagenous tissues. All the tissues of any one embryo, however, showed a similar degree of isotope incorporation. Tritiated ß-aminopropionitrile was diffusely distributed throughout bone and was completely removed by saline extraction. This autoradiographic study supports the postulate that a portion of extractable lathyritic collagen is recently synthesized and is organized in fibrous structures in bone.. ...
A method of controlling scar formation in humans by applying a force to tissue in an amount to create a wound; applying a lathyrogenic agent to the wound; forming the wound into a predetermined stationary or moveable beneficial configuration; and maintaining the wound in the predetermined configuration and in contact with lathyrogenic agent during healing.
The transcriptional activator IFN regulatory factor 1 (IRF-1) and its antagonistic repressor IRF-2 are regulators of the IFN system. IRF-1 also manifests tumor suppressive activity, and its inactivation could contribute to the development of human hematopoietic malignancies. Here, we report the identification of the lysyl oxidase gene as a target gene of IRF-1. An IRF response element was identified in the lysyl oxidase gene promoter. We also demonstrate that the transformed phenotype of ras-expressing embryonic fibroblasts with a null mutation in the IRF-1 allele could be suppressed by the expression of the lysyl oxidase cDNA, implicating its potential role in tumor suppression. Thus, the regulation of the lysyl oxidase gene by IRF-1 could contribute to the multistep process of malignant transformation.. ...
Olive oil is packed with a large number of phenolic compounds, which are the antioxidants that give the oil its pungent, bitter taste. According to an in-depth review published in Nutrition Research Reviews in June 2005, the most powerful of these compounds, such as hydroxytyrosol and oleuropein, can guard us from serious diseases like cancer, attack destructive microorganisms in our body and regulate the immune system.. Moreover, a study published in ACS Chemical Neuroscience in 2013 showed that another phenolic compound in olive oil, called oleocanthal, had neuroprotective properties and could shield us from Alzheimers disease, which is a leading cause of dementia. These results might explain why the Mediterranean diet, which uses olive oil freely, is associated with better cognitive function and lower rates of cognitive decline.. ...
The isolation of a salt-soluble homogeneous elastin from the aortas of lathyritic chicks by chromatography on DEAE-cellulose and salt precipitation is described. These new techniques, as well as some previously published by other workers, were evaluated with the help of antiserum raised in sheep against insoluble chick elastin. The purified elastin was very basic and behaved in a predictable manner in coacervation studies. The protein migrated in sodium dodecyl sulphate-polyacrylamide gels as a single band moving slightly faster than pyruvate kinase (mol.wt. 57000).. ...
... is a condition caused by eating certain legumes that contains toxic chemicals affecting the nervous system. The toxic chemicals lead to a loss of function in the nerves in the lower body. Individuals with this condition may experience leg weakness, leg paralysis, rigid muscles, shaking of the muscles, and severe pain. Species of legumes that could cause this condition include Lathyrus sativa, cicera, ochrus and clymenum. Diagnosis may include a physical exam and blood tests to look for toxins. Treatment depends on the severity of the symptoms. Nerve specialists may provide patients with neurotransmissive drugs that can help bring nerve function back to normal. Physical therapists may create exercise plans for individuals to strengthen their lower body muscles ...
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016 ...
The antihistaminics, Benadryl and Diatrin, sensitize peripheral organs to epinephrine as well as to sympathetic stimulation. In addition, these agents inhibit amine oxidase activity.. The antihistaminic, Anergen, does not inhibit amine oxidase and its effects on effector sites responding to epinephrine and sympathetic stimulation are variable.. ...
The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.
LOX propeptide, 0.1 ml. Lysyl oxidase (LOX) is an extracellular enzyme that is critical for the normal biosynthesis of collagens and elastin.
A dual-cell device has been designed as an oxidase-like mimic with the oxidation of 3,3′,5,5′-tetramethylbenzidine as a model reaction. This dual-cell device could be also used to study oxidase-like nanozymes. It was found that only the catalytic sites for oxygen reduction are essential and necessary for oxidase-li
Highlights: • Enhanced HSP47 and LOX expression is associated with decreased miR-29b level in liver fibrosis. • miR-29b down-regulates HSP47 and LOX expression. • The suppression of HSP47 and LOX by miR-29b is mediated by putative sites at their 3′-UTRs. • miR-29b inhibits extracellular LOX activity and collagen maturation. - Abstract: Altered expression of miR-29b is implicated in the pathogenesis and progression of liver fibrosis. We and others previously demonstrated that miR-29b down-regulates the expression of several extracellular-matrix (ECM) genes including Col 1A1, Col 3A1 and Elastin via directly targeting their 3′-UTRs. However, whether or not miR-29b plays a role in the post-translational regulation of ECM biosynthesis has not been reported. Heat shock protein 47 (HSP47) and lysyl oxidase (LOX) are known to be essential for ECM maturation. In this study we have demonstrated that expression of HSP47 and LOX was significantly up-regulated in culture-activated primary rat ...
Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how collagen cross-linking is regulated in epithelial tumors. To address this question, we used KrasLA1 mice, which develop lung adenocarcinomas from somatic activation of a KrasG12D allele. The lung tumors in KrasLA1 mice were highly fibrotic and contained cancer-associated fibroblasts (CAFs) that produced collagen and generated stiffness in collagen gels. In xenograft tumors generated by injection of wild-type mice with lung adenocarcinoma cells alone or in combination with CAFs, the total concentration of collagen cross-links was the same in tumors generated with or without CAFs, but co-injected tumors had higher hydroxylysine aldehyde-derived collagen cross-links (HLCCs) and lower lysine-aldehyde-derived collagen cross-links (LCCs). Therefore, we postulated that an LCC-to-HLCC switch induced by CAFs promotes the migratory and invasive properties of lung adenocarcinoma cells. To ...
During the last few years, accumulated evidence has supported a complex and pleiotropic role for proteins of the LOX family. Apart from their classical and widely reported function as ECM remodeling factors (Csiszar, 2001; Lucero & Kagan, 2006), emerging data have demonstrated the involvement of lysyl oxidases in a plethora of intracellular and extracellular processes (Barker et al, 2012; Cano et al, 2012). Generation of loss‐of‐function mouse models for Lox and Loxl1 has shed some light on tissue‐specific functions of these two LOX family members. The prototypic Lox plays a key role in the cardiovascular system (Maki et al, 2002; Hornstra et al, 2003), and Loxl1 was shown to be critical during the elastogenesis process (Liu et al, 2004). However, in vivo data concerning other members of the LOX family remain unexplored although similar multifunctional actions have been described, in particular for LOXL2 (Cano et al, 2012). Therefore, we generated deletion and overexpression mice for Loxl2 ...
We are studying how collagen cross-links have evolved to adapt human bone, cartilage and other supporting tissues for their distinctive functions. We have raise...
[cliccare il link per andare alla versione in italiano] minestra di cicerchie Cicerchia (Lathyrus sativus) is a legume that, according to this page (in Italian), was once widely consumed, while nowadays, it is grown only in central Italy. before (bottom) and after soaking Cicerchie are available only dried: prior to cooking, they must be soaked for 24 hours and the soaking water must be eliminated because it contains a neurotoxic amino acid (ODAP or BOAA) that can cause lathyrism. This condition was and remains a problem when and where lack of alternative food sources led to consumption of large quantities of...
Wiley Online Library will be unavailable on Saturday 7th Oct from 03.00 EDT / 08:00 BST / 12:30 IST / 15.00 SGT to 08.00 EDT / 13.00 BST / 17:30 IST / 20.00 SGT and Sunday 8th Oct from 03.00 EDT / 08:00 BST / 12:30 IST / 15.00 SGT to 06.00 EDT / 11.00 BST / 15:30 IST / 18.00 SGT for essential maintenance. Apologies for the inconvenience caused ...
The tumor stromal environment can dictate many aspects of tumor progression. A complete understanding of factors driving stromal activation and their role in tumor metastasis is critical to furthering research with the goal of therapeutic intervention. Polyoma middle T-induced mammary carcinomas lacking the type II TGF-β receptor (PyMT(mgko)) are highly metastatic compared with control PyMT-induced carcinomas (PyMT(fl/fl)). We hypothesized that the PyMT(mgko)-activated stroma interacts with carcinoma cells to promote invasion and metastasis. We show that the extracellular matrix associated with PyMT(mgko) tumors is stiffer and has more fibrillar collagen and increased expression of the collagen crosslinking enzyme lysyl oxidase (LOX) compared with PyMT(fl/fl) mammary carcinomas. Inhibition of LOX activity in PyMT(mgko) mice had no effect on tumor latency and size, but significantly decreased tumor metastasis through inhibition of tumor cell intravasation. This phenotype was associated with a ...
For riders who put in a lot of saddle time and require full coverage, nothing beats the Pearl Izumi Elite Gel FF Cycling Glove for men. The Elite FF cycling glov...
Scleroderma is a chronic skin-hardening disease. There are two types of scleroderma. The first type is called limited cutaneous scleroderma, where disrupted blood flow causes skin discoloration and sometimes patients experience high blood pressure in their arteries. The second type is called diffuse cutaneous scleroderma and it is much more aggressive, affecting a larger area of skin causing organ damage. This study will determine if the disease is associated with an elevated expression of LOXL2 levels in tissue samples from patients ...
Purified Recombinant Human LOXL2 Protein, His-tagged from Creative Biomart. Recombinant Human LOXL2 Protein, His-tagged can be used for research.
Histamine, found within granules of basophils and mast cells (,90% of body stores) is a biogenic amine and an organic nitrogen compound that occurs to various degrees in many foods such as cherries to about 0.17-13.46 ng/g, bananas and grapes, rice and cereals, herbs, olive oil, wine, beer, etc.. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity(a). the hormone, as a neurotransmitter is involved in regulating physiological function in the gut and immune response to foreign pathogens ...
Purpose : In Keratoconus (KC), the cornea is deformed and weakest at the corneal cone area while the surrounding cornea is of normal thickness. Alteration in gene expression patterns may be specific to the "cone" and hence treatment outcomes may be dependent on levels of molecular markers within the ectatic zone. This study evaluated the gene expression changes at the corneal "cone" normalized to the corneal "periphery" of each subject to rule out individual specific expression patterns. Methods : Corneal epithelium from 35 eyes (18 and 60 years) undergoing accelerated collagen crosslinking (9 mW/cm2 for 10 minutes (KXL) or customized beam profile based crosslinking, KXLII) was separately obtained from the cone and periphery for each subject. Ratio of gene expression [for lysyl oxidase (LOX), matrix metalloproteinase 9 (MMP 9), bone morphogenic protein (BMP7), tissue inhibitor of metalloproteinase (TIMP1), collagens (COL IA1 and COL IVA1)] from the cone vs peripheral cornea was correlated with ...
Mixed transition-metal oxides (MTMOs) have attracted much research interest because of their promising applications in artificial enzymes. In this work, uniform hollow MnCo2O4 nanofibers have been fabricated via an electrospinning technique followed by a calcination process, which can be used as efficient oxidase m
The connective tissue components, collagen types I, III and IV, which surround the ovarian follicles, undergo drastic changes during ovulation. Abnormal collagen synthesis and increased volume and density of ovarian stroma characterise the polycystic ovary syndrome (PCOS). Physiologically, collagen synthesis in ovarian follicles is partly regulated by lysyl oxidase (LOX), which catalyzes the collagen and elastin cross-linking and plays indispensable role in the organization of ovarian extracellular matrix (ECM) during follicular development. We have recently shown accumulation of advanced glycation end products (AGEs), nutritional metabolic products that stimulate ECM production and abnormal collagen cross-linking, in ovarian tissue of patients with PCOS. However, the possible link between LOX and AGEs-induced signaling in collagen assembly and stroma formation remain elusive. The present investigation explores the hypothesis that AGE-mediated signaling affects LOX gene transcription in ovarian ...
To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, peripheral blood sampling will be done from the patients with pseudoexfoliation.. And genotypes of the three single nucleotide polymorphisms of lysyl oxidase-like 1 gene , rs1048661, rs3825942, rs2165241 were analyzed by direct sequencing. ...
Sorghum species are drought-tolerant plants that may produce neuropathic and teratogenic manifestations. Sorghum poisoning has been seen primarily in the southwestern USA and Australia. The syndrome is reported almost exclusively in horses, although a similar disease has been reported in sheep and cattle. Lathyrogenic nitriles such as β-cyanoalanine, cyanogenic glycosides, and nitrates have been suggested as causative agents. The syndrome develops in horses after they have grazed hybrid Sudan pastures for weeks to months and produces axonal degeneration and myelomalacia in the spinal cord and cerebellum. (Also .) Consumption of the seed will not produce the syndrome.
Covalent cross-links hold many collagen molecules side by side, forming fibres.The ends of the parallel molecules are staggered.If they were not, there would be a weak spot running right across the collagen fibre.What is the meaning of staggered ends here? Why would there be a weak spot running right across the collagen fibre if the ends are not staggered? Thank you ...

Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism<...Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism<...

Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism. D. Kumar, M. B. Trent, P. J. Boor ... Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism. Toxicology. 1998 Feb 6;125(2-3): ... Allylamine and β-aminopropionitrile induced aortic medial necrosis : Mechanisms of synergism. / Kumar, D.; Trent, M. B.; Boor, ... Kumar, D. ; Trent, M. B. ; Boor, P. J. / Allylamine and β-aminopropionitrile induced aortic medial necrosis : Mechanisms of ...
more infohttps://researchexperts.utmb.edu/en/publications/allylamine-and-%CE%B2-aminopropionitrile-induced-aortic-medial-necrosi

Proplast
     Summary Report | CureHunterProplast Summary Report | CureHunter

Aminopropionitrile Related Therapies and Procedures. 1. Prostheses and Implants (Prosthesis) 2. Transplants (Transplant) ...
more infohttp://www.curehunter.com/public/keywordSummaryD011428-Proplast.do

Aminopropionitrile - WikipediaAminopropionitrile - Wikipedia

Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional ... Beta-amino-propionitrile (BAPN) found in lathyrus odoratus (common garden sweet pea) is thought to be responsible for ... Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile. Kashin-Beck disease Lysyl oxidase Marfan syndrome ... "Aminopropionitrile - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. ...
more infohttps://en.wikipedia.org/wiki/Aminopropionitrile

Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol | Cancer ResearchPotentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol | Cancer Research

Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol. Takehito Sasaki and Masahiko ... Young mice chronically treated with β-aminopropionitrile (BAPN) were subsequently given injections of graded doses of ... Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol ... Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol ...
more infohttp://cancerres.aacrjournals.org/content/39/7_Part_1/2751

GMD - [1647] 3-aminopropionitrile 2 [9.927]GMD - [1647] 3-aminopropionitrile 2 [9.927]

Metabolite mapped to [1647] 3-aminopropionitrile 2 [9.927]. metabolite. stereoisomer. isotopomer. 3-aminopropionitrile. ambient ... Details of [1647] 3-aminopropionitrile 2 [9.927]. rotate: click+drag; translate: alt. +click+drag; zoom: mousewheel; save: mol ... Reference spectra of [1647] 3-aminopropionitrile 2 [9.927]. replica. entry date. detection. method. species. ... Synonyms of [1647] 3-aminopropionitrile 2 [9.927]. property. value. Manual Interpretation [JKopka]. Proprionitril, 3-amino- ( ...
more infohttp://gmd.mpimp-golm.mpg.de/Analytes/29B8F304-0198-44C5-A659-D35773F3807E.aspx

3-Methoxy propionitrile|5-hydroxy-1-tetralone|3-(methyl amino)-propionitrile|3,6-Dichloro-4-methylpyridazine|3-Chloro-6-methyl...3-Methoxy propionitrile|5-hydroxy-1-tetralone|3-(methyl amino)-propionitrile|3,6-Dichloro-4-methylpyridazine|3-Chloro-6-methyl...

Product name: Ciprofloxacin hydrochloride CAS No.:86393-32-0 Molecular formula: C17H18FN3O3HCl Appearance: Faintly yellowish to light yellow crystals Residue on ignition: 0.1% Sulfate: 0.04% Heavy Metals: 20ppm Ph: 3.0-4.5 Water: 4.7% - 6.7
more infohttp://www.pharmapi.com/plus/view.php?aid=41

Reduced Collagen Biosynthesis Is the Hallmark of Cerebral Aneurysm | Arteriosclerosis, Thrombosis, and Vascular BiologyReduced Collagen Biosynthesis Is the Hallmark of Cerebral Aneurysm | Arteriosclerosis, Thrombosis, and Vascular Biology

To examine the role of LOX, some rats were fed food containing 0.12% β-aminopropionitrile (BAPN) (Tokyo Chemicals), a LOX ... Treatment with the LOX inhibitor β-aminopropionitrile resulted in enhanced progression of CA. Expression of procollagen type I ... Induction of Experimental CAs in Rats and β-Aminopropionitrile Treatment. Animal experiments complied with Japanese community ...
more infohttp://atvb.ahajournals.org/content/29/7/1080.long

GGT5 Gene - GeneCards | GGT5 Protein | GGT5 AntibodyGGT5 Gene - GeneCards | GGT5 Protein | GGT5 Antibody

beta-Aminopropionitrile. *2-Cyanoethylamine. *3-Aminopropanenitrile. *3-Aminopropionitrile. *3-Aminopropiononitrile. * ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=2687

Epithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis | Springer for Research & DevelopmentEpithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis | Springer for Research & Development

Rapamycin has been shown to attenuate fibrosis in the kidney and the liver [82, 83]. β-aminopropionitrile (BAPN) may suppress ...
more infohttps://rd.springer.com/article/10.1007%2Fs00535-018-1498-3

JAIRO | ß-aminopropionitrile投与による鶏胚骨格異常のJAIRO | ß-aminopropionitrile投与による鶏胚骨格異常の

ß-aminopropionitrile ベータアミノプロピオニトリル lathyrogen ラチロゲン bone development 骨発生 skeletal deformity 骨格変形 ... Characterization of skeletal deformities of chick embryo induced by administration of ß-aminopropionitrile. ...
more infohttp://jairo.nii.ac.jp/0354/00000663/en

Patent US5120322 - Method and apparatus for treatment of fibrotic lesions - Google PatentsPatent US5120322 - Method and apparatus for treatment of fibrotic lesions - Google Patents

Then a lathyrogenic agent, preferably D-penicillinamine or Beta-aminopropionitrile (BAPN), or Beta-aminopropionitrile fumarate ... b) applying B-aminopropionitrile fumarate onto a catheter;. c) inserting the catheter into the tubular body portion for a ... 5. The method defined in claim 1 wherein the lathyrogenic agent is B-aminopropionitrile fumarate. ... 4 (October 1972). However, serious toxicity problems were encountered with systemically introduced Beta-aminopropionitrile ...
more infohttp://www.google.com/patents/US5120322?dq=5,675,808

Wheeless Textbook of OrthopaedicsWheeless' Textbook of Orthopaedics

ibuprofen, beta amino propionitrile, and steroids;. - references:. - Effects of Nonsteroidal Anti-Inflammatory Drugs on Flexor ...
more infohttp://www.wheelessonline.com/ortho/post_op_care_for_flexor_tendon_repair

Popis opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za...Popis opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za...

Narodne novine d.d se obvezuju poštivati anonimnost i privatnost korisnika ovih internetskih stranica. O posjetiteljima se neće prikupljati nikakvi osobni podaci osim u slučajevima ako ih posjetitelj dobrovoljno dostavi Narodnim novinama d.d. U slučajevima kad je poznat indentitet posjetitelja/pošiljatelja, njegovi će se podaci koristiti samo u svrhu zbog koje ih je pošiljatelj poslao. Narodne novine d.d. takve podatke mogu koristiti i za što bolji uvid i razumijevanja pojedinačnih potreba i zahtjeva korisnika kao i razvijanja mogućnosti što kvalitetnijega pružanja svojih usluga korisnicima. Narodne novine d.d. se obvezuju da navedene podatke neće učiniti dostupnim bilo kojoj trećoj osobi odnosno strani bez izričitoga pristanka korisnika ...
more infohttps://narodne-novine.nn.hr/clanci/sluzbeni/2004_11_163_2865.html

Metabolic and functional alterations of copper in diabetes mellitusMetabolic and functional alterations of copper in diabetes mellitus

Reversal by b-aminopropionitrile and D-penicillamine. Diabetes, New York, v.29, n.10, p.778-781, 1980. [ Links ]. CHEN, Y., ...
more infohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52731999000300002

connective tissue growth factor Protocols and Video...'connective tissue growth factor' Protocols and Video...

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection ... Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection. ...
more infohttps://www.jove.com/keyword/connective+tissue+growth+factor

Molbank | Free Full-Text | 1-{[Benzyl-(2-cyano-ethyl)-amino]-methyl}-5-methyl-1H-pyrazole-3-carboxylic acid ethyl esterMolbank | Free Full-Text | 1-{[Benzyl-(2-cyano-ethyl)-amino]-methyl}-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

3-[Benzyl-(3,5-dimethyl-pyrazol-1-ylmethyl)-amino]-propionitrile. Previous Article in Journal. 1-{[Benzyl-(2-cyano-ethyl)-amino ...
more infohttp://www.mdpi.com/1422-8599/2006/5/M494

Chapter 4: Electrophoresis - IntroductionChapter 4: Electrophoresis - Introduction

dimethyl amino-propionitrile (DMAP) or N,N,N. ,N. ,- tetramethylethylenediamine (TEMED). The gels are neutral, hydrophillic, ...
more infohttp://homepages.gac.edu/~cellab/chpts/chpt4/intro4.html

JCI -
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertensionJCI - Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

Reduction of chronic hypoxic pulmonary hypertension in the rat by β-aminopropionitrile. J Appl Physiol Respir Environ Exerc ... In parallel but in separate rat cohorts, 1 day after monocrotaline injection, β-aminopropionitrile (BAPN; 100 mg/kg/d; Sigma- ... First, using a known pharmacologic inhibitor (β-aminopropionitrile, BAPN) of lysyl oxidase (Lox), the enzyme responsible for ... Reduction of blood pressure and vascular collagen in hypertensive rats by beta-aminopropionitrile. Proc Natl Acad Sci U S A. ...
more infohttps://www.jci.org/articles/view/86387

Management of Marfan syndrome | HeartManagement of Marfan syndrome | Heart

Beta-Aminopropionitrile-induced dissecting aneurysms of turkeys: treatment with propranolol. Toxicol Appl Pharmacol 1970;16:143 ... Influence of d-,l- and dl-propranolol, and practolol on beta-amino-propionitrile-induced aortic ruptures of turkeys. Toxicol ...
more infohttps://heart.bmj.com/content/88/1/97?ijkey=7fd2c646a7411ddcc84a36c296c863a193f07fb8&keytype2=tf_ipsecsha

The PLGA Implant as an Antimitotic Delivery System After Experimental Trabeculectomy | IOVS | ARVO JournalsThe PLGA Implant as an Antimitotic Delivery System After Experimental Trabeculectomy | IOVS | ARVO Journals

D-penicillamine and beta-aminopropionitrile effects on experimental filtering surgery. Invest Ophthalmol Vis Sci . 1987; 28: ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2127826

JCI Insight -
Molecular imaging of oxidized collagen quantifies pulmonary and hepatic fibrogenesisJCI Insight - Molecular imaging of oxidized collagen quantifies pulmonary and hepatic fibrogenesis

beta-Aminopropionitrile prevents bleomycin-induced pulmonary fibrosis in the hamster. Am Rev Respir Dis. 1982;125(1):67-73. ... Reaction of aortic lysyl oxidase with beta-aminopropionitrile. J Biol Chem. 1983;258(7):4331-4338.. View this article via: ... β-aminopropionitrile (BAPN) (27). We imaged mice that had been administered bleomycin or PBS at 1 or 2 weeks after challenge, ...
more infohttps://insight.jci.org/articles/view/91506

Ghent University Academic BibliographyGhent University Academic Bibliography

Non-enzymatic pharmacologic vitreolysis by beta-aminopropionitrile (BAPN) Elisabeth Van Aken UGent, Lara Derycke UGent, Halima ...
more infohttps://biblio.ugent.be/publication?q=affiliation+exact+GE18&q=author+exact+001993259868

Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis | IOVS | ARVO JournalsDownregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis | IOVS | ARVO Journals

The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast ... or exposed to β-aminopropionitrile (BAPN), a LOX inhibitor. LOX expression, AKT activation, and caspase-3 activity were ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2629437
  • We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. (utmb.edu)
  • Treatment with the LOX inhibitor β-aminopropionitrile resulted in enhanced progression of CA. Expression of procollagen type I, III, and LOX was inhibited by interleukin-1β (IL-1β) in cultured rat aortic smooth muscle cells (RASMCs) in vitro. (ahajournals.org)
  • We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. (utmb.edu)
  • Tritiated ß-aminopropionitrile was diffusely distributed throughout bone and was completely removed by saline extraction. (rupress.org)