Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.
The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
A nucleoside diphosphate sugar formed from GDPmannose, which provides fucose for lipopolysaccharides of bacterial cell walls, and for blood group substances and other glycoproteins.
Esters formed between the aldehydic carbon of sugars and the terminal phosphate of guanosine diphosphate.
A nucleoside diphosphate sugar which can be converted to the deoxy sugar GDPfucose, which provides fucose for lipopolysaccharides of bacterial cell walls. Also acts as mannose donor for glycolipid synthesis.
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
The main trunk of the systemic arteries.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.
A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.
Freedom of equipment from actual or potential hazards.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
Criteria to determine eligibility of patients for medical care programs and services.
The aggregate enterprise of manufacturing and technically producing books. (From Random House Unabridged Dictionary, 2d ed)
Laws concerned with manufacturing, dispensing, and marketing of drugs.
A paralytic condition of the legs caused by ingestion of lathyrogens, especially BETA-AMINOPROPIONITRILE or beta-N-oxalyl amino-L-alanine, which are found in the seeds of plants of the genus LATHYRUS.
A proline analog that acts as a stoichiometric replacement of proline. It causes the production of abnormal proteins with impaired biological activity.
An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Databases devoted to knowledge about specific genes and gene products.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Restoration of integrity to traumatized tissue.
Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.
Long-term changes in the electrophysiological parameters and/or anatomical structures of the HEART ATRIA that result from prolonged changes in atrial rate, often associated with ATRIAL FIBRILLATION or long periods of intense EXERCISE.
The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.
Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
Organic chemicals which have two amino groups in an aliphatic chain.
The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.

The smooth muscle cell. III. Elastin synthesis in arterial smooth muscle cell culture. (1/87)

Primate arterial smooth muscle cells and skin fibroblasts were examined for their ability to synthesize elastin in culture. In the presence of the lathyrogen beta-aminopropionitrile, the smooth muscle cells incorporate [3H]lysine into a lysyl oxidase substrate that was present in the medium and associated with the cell layer. A component having a mol wt of 72,000 and an electrophoretic mobility similar to that of authentic tropoelastin was isolated from the labeled smooth muscle cells by coacervation and fractionation with organic solvents. In the absence of beta-aminopropionitrile, long-term cultures of smooth muscle cells incorporated [14C]lysine into desmosine and isodesmosine, the cross-link amino acids unique to elastin. In contrast, no desmosine formation occurred in the fibroblast cultures. These characteristics demonstrate that arterial smooth muscle cells are capable of synthesizing both soluble and cross-lined elastin in culture.  (+info)

Lysyl oxidase activates the transcription activity of human collagene III promoter. Possible involvement of Ku antigen. (2/87)

Lysyl oxidase is an extracellular enzyme that controls the maturation of collagen and elastin. Lysyl oxidase and collagen III often show similar expression patterns in fibrotic tissues. Therefore, we investigated the influence of lysyl oxidase overexpression on the promoter activity of human COL3A1 gene. Our results showed that when COS-7 cells overexpressed the mature form of lysyl oxidase, the activity of the human COL3A1 promoter was increased up to an average of 12 times when tested by luciferase reporter assay. The effect was specific, because other promoters were not affected. Moreover, lysyl oxidase effect was abolished by beta-aminopropionitrile, a specific inhibitor of its catalytic activity. Electrophoretic mobility shift assay showed a binding activity in the region from -101 to -77 that was significantly increased by lysyl oxidase overexpression. The binding was specifically competed by the cold probe, and the mutagenesis of this region abolished both the binding activity in gel retardation and lysyl oxidase stimulation of COL3A1 promoter in transfection experiments. We identified the binding activity as Ku antigen in its two components: Ku80 and Ku70. This study suggests a new coordinated mechanism by which lysyl oxidase might control the development of fibrosis.  (+info)

Collagen synthesis in capsules surrounding dimethylbenzanthracene-induced rat breast tumors and the effect of pretreatment with beta-aminopropionitrile. (3/87)

Collagen synthesis is increased over three-fold in capsules surrounding dimethylbenzanthracene-induced rat breast tumors compared to the tumor parenchyma and over six-fold compared to normal breast connective tissue. Increased collagen synthesis is independent of the rate of tumor growth and final tumor size. Pretreatment of animals with beta-aminopropionitrile to inhibit collagen cross-linking caused an 82% decrease in tumor formation and a significant reduction in tumor volume (approximately 0.4 cu cm) compared to controls (approximately 10 cu cm). The four small tumors that did develop in the lathyritic animals had increased collagen synthesis in the interior tumor stroma and reduced collagen synthesis in the tumor capsule. These findings suggest that the collagenous capsule surrounding dimethylbenzanthracene tumors functions as a physical barrier to protect the tumor from the immune system of the host. The apparent antitumor effects of beta-aminopropionitrile may be due to immunopotentiation and/or cytotoxic actions of the drug.  (+info)

Analysis of the combined osteolathyritic effects of beta-aminopropionitrile and diethyldithiocarbamate on xenopus development. (4/87)

In order to examine the mechanistic basis between combined effects and mechanisms of action, two osteolathyrogens, beta-aminopropionitrile (betaAPN) and diethyldithiocarbamate (DTC), were tested together on Xenopus embryos. In a separate test, DTC was also tested with copper sulfate to determine the importance of copper in DTC-induced osteolathyrism. Frog embryos (Xenopus laevis) were exposed for 96 h, with daily solution removal and replacement. Preserved tadpoles were evaluated for osteolathyritic lesions. For the betaAPN:DTC test, a 1.2-factor matrix design was used, producing two single chemical and seven mixture-response curves. The chi(2) goodness-of-fit test was used to compare the experimental mixture-response curves with theoretical effects for two combined effects models, dose-addition and independence. All seven mixture curves were consistent with expected results for dose-addition, but the correlations were generally not high. For the DTC:copper test, the three mixture-response curves generated showed that added copper increased the DTC-alone EC(50), but there was no corresponding right shift at the top of the response curves, as observed previously with betaAPN and copper. In the betaAPN:DTC and DTC:copper tests, DTC alone showed a biphasic concentration-osteolathyrism curve, and the slope of the response curve for DTC alone in each test was statistically different than the slope for the betaAPN alone response curve. Taken together, the results suggest the potential for a second osteolathyritic effect of DTC that affected the combined toxicity enough to produce a dose-addition correlation without the chemicals necessarily having the same mechanism.  (+info)

Amine oxidase-like activity of polyphenols. Mechanism and properties. (5/87)

Polyphenols in several oxidation systems gained amine oxidase-like activity, probably due to the formation of the corresponding quinones. In the presence of Cu(II), o- and p-phenolic compounds exhibited amine oxidase-like activity, whereas only the o-phenolic compounds showed the activity in the presence of 1,1-diphenyl-2-picrylhydrazyl radical. The activity was determined by measuring the conversion of benzylamine to benzaldehyde by HPLC. Moreover, gallic acid, chlorogenic acid, and caffeic acid, which are plant polyphenols, converted the lysine residue of bovine serum albumin to alpha-amino-adipic semialdehyde residue, indicating lysyl oxidase-like activity. We also characterized the activity of pyrocatechol, hydroquinone, and pyrogallol in the presence of Cu(II). The oxidative deamination was accelerated at a higher pH, and required O2 and transition metal ions. Furthermore, EDTA markedly inhibited the reaction but not beta-aminopropionitrile, which is a specific inhibitor of lysyl oxidase. Catalase significantly inhibited the oxidation, implying the participation of hydroxyl radical in the reaction, but superoxide dismutase stimulated the oxidation, probably due to its radical formation activity. We discussed the mechanism of the oxidative deamination by polyphenols and the possible significance of the activity for biological systems.  (+info)

The effect of beta aminoproprionitrile (BAPN) on experimental amyloidosis. (6/87)

Experimental amyloidosis was induced in mice with repeated injections of complete Freund's adjuvant (CFA) reinforced with bacterial vaccine. BAPN administered in a mixture with CFA or on its own before the injection of CFA reduced the incidence of amyloidosis. The reduction in the incidence of amyloidosis following the administration of BAPN may be due to its inhibitory effect on the oxidative deamination of amino acids, which presumably inhibit cross-linking of amyloid fibrils or interfere with metabolic pathways which involve the formations of mucopolysaccharide formation. It is suggested that the defective formation of the mucopolysaccharide-amyloid protein complex inhibits amyloid deposition and induces the activity of beta glucuronidase observed in the present study. The reduced incidence of amyloidosis following BAPN adminsitration cannot be due to lysosomal enzyme degradation of the amyloid as the activity of cathepsin D and acid phosphatase is decreased during this process.  (+info)

A molecular role for lysyl oxidase in breast cancer invasion. (7/87)

We identified previously an up-regulation in lysyl oxidase (LOX) expression,an extracellular matrix remodeling enzyme, in a highly invasive/metastatic human breast cancer cell line, MDA-MB-231, compared with MCF-7, a poorly invasive/nonmetastatic breast cancer cell line. In this study, we demonstrate that the mRNA expression of LOX and other LOX family members [lysyl oxidase-like (LOXL), LOXL2, LOXL3, and LOXL4] was observed only in breast cancer cells with a highly invasive/metastatic phenotype but not in poorly invasive/nonmetastatic breast cancer cells. LOX and LOXL2 showed the strongest association with invasive potential in both highly invasive/metastatic breast cancer cell lines tested (MDA-MB-231 and Hs578T). To determine whether LOX is directly involved in breast cancer invasion, LOX antisense oligonucleotides were transfected into MDA-MB-231 and Hs578T cells, and found to inhibit invasion through a collagen IV/laminin/gelatin matrix in vitro compared with LOX sense oligonucleotide-treated and untreated controls. In addition, treatment of MDA-MB-231 and Hs578T cells with beta-aminopropionitrile (an irreversible inhibitor of LOX enzymatic activity) decreased invasive activity. Conversely, MCF-7 cells transfected with the murine LOX gene demonstrated a 2-fold increase in invasiveness that was reversible by the addition of beta-aminopropionitrile in a dose-dependent manner. In addition, endogenous LOX mRNA expression was induced when MCF-7 cells were cultured in the presence of fibroblast conditioned medium or conditioned matrix, suggesting a role for stromal fibroblasts in LOX regulation in breast cancer cells. Moreover, the correlation of LOX up-regulation and invasive/metastatic potential was additionally demonstrated in rat prostatic tumor cell lines, and human cutaneous and uveal melanoma cell lines. These results provide substantial new evidence that LOX is involved in cancer cell invasion.  (+info)

An angiotensin-converting enzyme inhibitor, not an angiotensin II type-1 receptor blocker, prevents beta-aminopropionitrile monofumarate-induced aortic dissection in rats. (8/87)

OBJECTIVE: Cystic medial degeneration (CMD) is a histologic abnormality that is common in aortic diseases such as aortic dilation, aneurysm, or dissection. Although little is known about the mechanism underlying CMD, we have previously demonstrated that angiotensin II signaling via angiotensin II type 2 receptor (AT2R) plays a central role in apoptosis of vascular smooth muscle cells (VSMCs) occurring in CMD associated with Marfan syndrome. The aim of this study is to elucidate the role of angiotensin II signaling in THE pathogenesis of aortic diseases associated with CMD. METHOD: We investigated the effects of angiotensin-converting enzyme inhibitor (ACEI), temocapril (n = 15), angiotensin II receptor type-1 (AT1R) blocker, CS-866 (n = 15), and vehicle control (n = 17) on 0.25% beta-aminopropionitrile monofumarate (BAPN)-induced aortic dissection and histopathologic findings in a rat model. RESULTS: Temocapril significantly prevented aortic dissection (P <.05), CMD (P <.01), and VSMC apoptosis (P <.01) compared with vehicle control in BAPN-fed rats. However, CS-866 did not show any preventive effect. Reversed transcriptase-polymerase chain reaction demonstrated that expression of both AT1R and AT2R was detected in control rat aortas, and that AT2R expression was significantly upregulated in the aortas of BAPN-fed rats (P <.01). Blood pressure was significantly and equally lowered in both temocapril and CS-866 groups compared with control. CONCLUSIONS: Differential expression of angiotensin II receptors and AT2R signaling are involved in the pathogenesis of CMD and aortic dissection in BAPN-fed rats. ACEIs might be of clinical value for the prevention and treatment of aortic diseases related to CMD.  (+info)

Post a Comment for Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick aorta : a mongraphic study by Susan Averill Taylor. ...
ß-aminopropionitrile投与による鶏胚骨格異常の解析ß-aminopropionitrile投与による鶏胚骨格異常の解析 ...
Administration of an antifibrotic agent as an adjunct to antihelmintic treatment with the objective of morbidity reduction was investigated in the murine schistosomiasis mansoni model. Antifibrotic, beta-aminopropionitrile treatment has a profound effect on the cellular matrix composition of the liver granuloma of Schistosoma mansoni infected mice when given alone, resulting in increase macrophage infiltration. These macrophages, in response to stimulation with soluble egg antigen or lipopolysaccharide produced elevated levels of nitric oxide but low levels of tumor necrosis factor alpha compared to untreated infected mice. This also correlated with reduced liver granuloma size. In spite of low numbers of eggs in the liver, mice receiving a combine treatment had a high level of resistance to a challenge infection compared with mice receiving only praziquantel. Those mice also exhibited a reduced lymphocyte proliferative response, similar to that of infected untreated mice. Antifibrotic treatment ...
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
TY - JOUR. T1 - Effects of induction and inhibition of matrix cross-linking on remodeling of the aqueous outflow resistance by ocular trabecular meshwork cells. AU - Yang, Yong Feng. AU - Sun, Ying Ying. AU - Acott, Ted. AU - Keller, Kate. PY - 2016/7/28. Y1 - 2016/7/28. N2 - The trabecular meshwork (TM) tissue controls drainage of aqueous humor from the anterior chamber of the eye primarily by regulating extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs). Glaucomatous TM tissue is stiffer than age-matched controls, which may be due to alterations in ECM cross-linking. In this study, we used genipin or beta-Aminopropionitrile (BAPN) agents to induce or inhibit matrix cross-linking, respectively, to investigate the effects on outflow resistance and ECM remodeling. Treatment with BAPN increased outflow rates in perfused human and porcine anterior segments, whereas genipin reduced outflow. Using a fluorogenic peptide assay, MMP activity was increased with BAPN treatment, but ...
TY - JOUR. T1 - Allylamine and β-aminopropionitrile induced aortic medial necrosis. T2 - Mechanisms of synergism. AU - Kumar, D.. AU - Trent, M. B.. AU - Boor, P. J.. PY - 1998/2/6. Y1 - 1998/2/6. N2 - We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. Either toxin given alone does not cause aortic lesions. In order to shed light on the mechanism of the synergistic action of these two toxins we fed known modulators of AA or βAPN toxicity to rats concurrently with the two toxins. As modulators we used (a) semicarbazide (98 mg/kg/day, given 4 h prior to toxins), a known inhibitor of the vascular enzyme SSAO which metabolizes AA (b) L-cysteine (1.5% in rat chow, beginning 3 days prior to toxins), which has been shown to reduce the toxic effects of βAPN; and (c) phenelzine sulphate (3 mg/kg/day, given 4 h prior to toxins), an inhibitor of ...
In normal and lathyritic chick embryos bone collagen was synthesized primarily in the periosteum of the femurs, and was organized as radioactive spicules in these bones. Saline extraction of the lathyritic bones removed the radioactive spicules, although they eventually seemed to become non-extractable. Normal bone seemed to be unaffected by saline extraction. Marked variation in the degree of isotope incorporation was seen in collagenous and non-collagenous tissues. All the tissues of any one embryo, however, showed a similar degree of isotope incorporation. Tritiated ß-aminopropionitrile was diffusely distributed throughout bone and was completely removed by saline extraction. This autoradiographic study supports the postulate that a portion of extractable lathyritic collagen is recently synthesized and is organized in fibrous structures in bone.. ...
Lysyl Oxidase antibody LS-C141074 is a DY488-conjugated rabbit polyclonal antibody to human Lysyl Oxidase (LOX) (aa300-400). Validated for IHC and WB.
A method of controlling scar formation in humans by applying a force to tissue in an amount to create a wound; applying a lathyrogenic agent to the wound; forming the wound into a predetermined stationary or moveable beneficial configuration; and maintaining the wound in the predetermined configuration and in contact with lathyrogenic agent during healing.
The transcriptional activator IFN regulatory factor 1 (IRF-1) and its antagonistic repressor IRF-2 are regulators of the IFN system. IRF-1 also manifests tumor suppressive activity, and its inactivation could contribute to the development of human hematopoietic malignancies. Here, we report the identification of the lysyl oxidase gene as a target gene of IRF-1. An IRF response element was identified in the lysyl oxidase gene promoter. We also demonstrate that the transformed phenotype of ras-expressing embryonic fibroblasts with a null mutation in the IRF-1 allele could be suppressed by the expression of the lysyl oxidase cDNA, implicating its potential role in tumor suppression. Thus, the regulation of the lysyl oxidase gene by IRF-1 could contribute to the multistep process of malignant transformation.. ...
Olive oil is packed with a large number of phenolic compounds, which are the antioxidants that give the oil its pungent, bitter taste. According to an in-depth review published in Nutrition Research Reviews in June 2005, the most powerful of these compounds, such as hydroxytyrosol and oleuropein, can guard us from serious diseases like cancer, attack destructive microorganisms in our body and regulate the immune system.. Moreover, a study published in ACS Chemical Neuroscience in 2013 showed that another phenolic compound in olive oil, called oleocanthal, had neuroprotective properties and could shield us from Alzheimers disease, which is a leading cause of dementia. These results might explain why the Mediterranean diet, which uses olive oil freely, is associated with better cognitive function and lower rates of cognitive decline.. ...
The isolation of a salt-soluble homogeneous elastin from the aortas of lathyritic chicks by chromatography on DEAE-cellulose and salt precipitation is described. These new techniques, as well as some previously published by other workers, were evaluated with the help of antiserum raised in sheep against insoluble chick elastin. The purified elastin was very basic and behaved in a predictable manner in coacervation studies. The protein migrated in sodium dodecyl sulphate-polyacrylamide gels as a single band moving slightly faster than pyruvate kinase (mol.wt. 57000).. ...
TY - JOUR. T1 - The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. AU - Baker, Ann-Marie. AU - Cox, Thomas R.. AU - Bird, Demelza. AU - Lang, Georgina. AU - Murray, Graeme I.. AU - Sun, Xiao-Feng. AU - Southall, Stacey M.. AU - Wilson, Jon R.. AU - Erler, Janine T.. PY - 2011/3/2. Y1 - 2011/3/2. N2 - Background: Emerging evidence implicates lysyl oxidase (LOX), an extracellular matrix-modifying enzyme, in promoting metastasis of solid tumors. We investigated whether LOX plays an important role in the metastasis of colorectal cancer (CRC). Methods: We analyzed LOX expression in a patient CRC tissue microarray consisting of normal colon mucosa (n = 49), primary (n = 510), and metastatic (n = 198) tissues. LOX was overexpressed in CRC cell line SW480 (SW480+LOX), and the expression was knocked down in CRC cell line SW620 using LOX-specific short hairpin RNA (SW620+shLOX). Effect of LOX manipulation on three-dimensional cell proliferation and invasion was ...
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016 ...
The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.
LOX propeptide, 0.1 ml. Lysyl oxidase (LOX) is an extracellular enzyme that is critical for the normal biosynthesis of collagens and elastin.
TY - JOUR. T1 - Histochemical Evidence of Aldehyde Blocking Capacity of Lathyrogenic Agents. AU - Yeager, Vernon L.. AU - Sevekson, Arlen R.. PY - 1961/12. Y1 - 1961/12. N2 - This study has demonstrated that compounds known to possess lathyrogenic properties may, or may not, block the periodic acid-Schiff reaction, and that for these compounds, no correlation exists between their aldehyde blocking capacity and their ability to produce lathyrism in tadpoles. The mechanism by which those compounds produce lathyrism therefore continues to be obscure.. AB - This study has demonstrated that compounds known to possess lathyrogenic properties may, or may not, block the periodic acid-Schiff reaction, and that for these compounds, no correlation exists between their aldehyde blocking capacity and their ability to produce lathyrism in tadpoles. The mechanism by which those compounds produce lathyrism therefore continues to be obscure.. UR - ...
A dual-cell device has been designed as an oxidase-like mimic with the oxidation of 3,3′,5,5′-tetramethylbenzidine as a model reaction. This dual-cell device could be also used to study oxidase-like nanozymes. It was found that only the catalytic sites for oxygen reduction are essential and necessary for oxidase-li
AIMS: After myocardial infarction (MI), extensive remodelling of the extracellular matrix contributes to scar formation. While aiming to preserve tissue integrity, this fibrotic response is also associated with adverse events, including a markedly increased risk of heart failure, ventricular arrhythmias, and sudden cardiac death. Cardiac fibrosis is characterized by extensive deposition of collagen and also by increased stiffness as a consequence of enhanced collagen cross-linking. Members of the lysyl oxidase (LOX) family of enzymes are responsible for the formation of collagen cross-links. This study investigates the contribution of LOX family members to the heart response to MI. METHODS AND RESULTS: Experimental MI was induced in C57BL/6 mice by permanent ligation of the left anterior descending coronary artery. The expression of LOX isoforms (LOX and LOXL1-4) was strongly increased upon MI, and this response was accompanied by a significant accumulation of mature collagen fibres in the ...
Reactivity: Chicken, Cow, Human and more. Compare different LOXL2 ELISA Kits & buy the right one directly at antibodies-online.com!
Description: Quantitativesandwich ELISA kit for measuring Human Lysyl oxidase homolog 3(LOXL3) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits ...
Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how collagen cross-linking is regulated in epithelial tumors. To address this question, we used KrasLA1 mice, which develop lung adenocarcinomas from somatic activation of a KrasG12D allele. The lung tumors in KrasLA1 mice were highly fibrotic and contained cancer-associated fibroblasts (CAFs) that produced collagen and generated stiffness in collagen gels. In xenograft tumors generated by injection of wild-type mice with lung adenocarcinoma cells alone or in combination with CAFs, the total concentration of collagen cross-links was the same in tumors generated with or without CAFs, but co-injected tumors had higher hydroxylysine aldehyde-derived collagen cross-links (HLCCs) and lower lysine-aldehyde-derived collagen cross-links (LCCs). Therefore, we postulated that an LCC-to-HLCC switch induced by CAFs promotes the migratory and invasive properties of lung adenocarcinoma cells. To ...
LIU Y ; WHIGHAM BT ; WHEELER J ; WILLIAMS SEI ; Rautenbach RM ; Ziskind A ; Ramsay M ; CARMICHAEL TR ; Ashley-Koch AE ; Rand Allingham R ; Hauser M (2012) ...
During the last few years, accumulated evidence has supported a complex and pleiotropic role for proteins of the LOX family. Apart from their classical and widely reported function as ECM remodeling factors (Csiszar, 2001; Lucero & Kagan, 2006), emerging data have demonstrated the involvement of lysyl oxidases in a plethora of intracellular and extracellular processes (Barker et al, 2012; Cano et al, 2012). Generation of loss‐of‐function mouse models for Lox and Loxl1 has shed some light on tissue‐specific functions of these two LOX family members. The prototypic Lox plays a key role in the cardiovascular system (Maki et al, 2002; Hornstra et al, 2003), and Loxl1 was shown to be critical during the elastogenesis process (Liu et al, 2004). However, in vivo data concerning other members of the LOX family remain unexplored although similar multifunctional actions have been described, in particular for LOXL2 (Cano et al, 2012). Therefore, we generated deletion and overexpression mice for Loxl2 ...
Background/Aims: Maintenance of bone quality is important in the prevention of osteoporotic fracture. Bone quality is determined by collagen cross-links which are regulated by enzyme lysyl oxidase (LOX) in osteoblastic cells. LOX expression is known to be inhibited by activation of Janus kinase (JAK) signaling located in the upstream of LOX. But, JAK signaling is reported to be inhibited by Tocotrienol-Rich Fraction (TRF), a member of the vitamin E family. However, the effect of TRF on the LOX expression in osteoblastic cells has not been understood. Here, we have investigated the relation between TRF and LOX expression.. Methods: A human osteosarcoma cell line (MG-63) was cultured in medium containing 5 µg/ml or 10 µg/ml TRF. After 24 h of treatment TRF, we analyzed LOX mRNA expression and JAK1, JAK2 protein expression and activation. Analyses of mRNA expression and of protein expression and activation were performed by real-time PCR and westernblotting respectively. Expression and activation ...
For riders who put in a lot of saddle time and require full coverage, nothing beats the Pearl Izumi Elite Gel FF Cycling Glove for men. The Elite FF cycling glov...
Orthopaedic Specialists of North Carolina. Dr. Wheeless enjoys and performs all types of orthopaedic surgery but is renowned for his expertise in total joint arthroplasty (Hip and Knee replacement) as well as complex joint infections. He founded Orthopaedic Specialists of North Carolina in 2001 and practices at Franklin Regional Medical Center and Duke Raleigh Hospital.. » More about Dr. Wheeless. ...
Tumor cell metastasis is facilitated by premetastatic niches formed in destination organs by invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for premetastatic niche formation. LOX secreted by hypoxic breast tumor cells accumulates at premetastatic sites, crosslinks coll …
An excess of OPN is associated with increased LOX and insoluble collagen, as well as with LV stiffness and systolic dysfunction in patients with HHD and HF. In addition, OPN up-regulates LOX in human fibroblasts. It is suggested that the OPN-LOX axis might facilitate the formation of insoluble colla …
Purified Recombinant Human LOXL2 Protein, His-tagged from Creative Biomart. Recombinant Human LOXL2 Protein, His-tagged can be used for research.
The molecule lysyl oxidase promotes skin and lung scarring in scleroderma and may serve as a biomarker and therapeutic target, a study says.
TY - JOUR. T1 - Human bone collagen synthesis is a rapid, nutritionally modulated process. AU - Babraj, John A.. AU - Smith, Kenneth. AU - Cuthbertson, Daniel J.R.. AU - Rickhuss, Peter. AU - Dorling, James S.. AU - Rennie, Michael J.. PY - 2005/6. Y1 - 2005/6. N2 - We developed a direct assay of human bone collagen synthesis using [13C] or [15N] proline and applied it to determine the effects of feeding in young healthy men. Surprisingly, postabsorptive bone collagen synthesis is not sluggish, being ∼0.07%/h more rapid than that of muscle protein, and capable of being stimulated within 4 h of intravenous feeding by 66 ± 13%.Introduction: All current methods for estimation of bone collagen turnover are indirect, depending on the assay of collagen markers. Our aim was to develop a direct method for human bone collagen synthesis to be used to study its physiology and pathology, and specifically, in the first instance, the effect of feeding.Materials and methods: We applied, over 2 h, flooding ...
Histamine, found within granules of basophils and mast cells (,90% of body stores) is a biogenic amine and an organic nitrogen compound that occurs to various degrees in many foods such as cherries to about 0.17-13.46 ng/g, bananas and grapes, rice and cereals, herbs, olive oil, wine, beer, etc.. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity(a). the hormone, as a neurotransmitter is involved in regulating physiological function in the gut and immune response to foreign pathogens ...
Mixed transition-metal oxides (MTMOs) have attracted much research interest because of their promising applications in artificial enzymes. In this work, uniform hollow MnCo2O4 nanofibers have been fabricated via an electrospinning technique followed by a calcination process, which can be used as efficient oxidase m
The connective tissue components, collagen types I, III and IV, which surround the ovarian follicles, undergo drastic changes during ovulation. Abnormal collagen synthesis and increased volume and density of ovarian stroma characterise the polycystic ovary syndrome (PCOS). Physiologically, collagen synthesis in ovarian follicles is partly regulated by lysyl oxidase (LOX), which catalyzes the collagen and elastin cross-linking and plays indispensable role in the organization of ovarian extracellular matrix (ECM) during follicular development. We have recently shown accumulation of advanced glycation end products (AGEs), nutritional metabolic products that stimulate ECM production and abnormal collagen cross-linking, in ovarian tissue of patients with PCOS. However, the possible link between LOX and AGEs-induced signaling in collagen assembly and stroma formation remain elusive. The present investigation explores the hypothesis that AGE-mediated signaling affects LOX gene transcription in ovarian ...
To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, peripheral blood sampling will be done from the patients with pseudoexfoliation.. And genotypes of the three single nucleotide polymorphisms of lysyl oxidase-like 1 gene , rs1048661, rs3825942, rs2165241 were analyzed by direct sequencing. ...
Covalent cross-links hold many collagen molecules side by side, forming fibres.The ends of the parallel molecules are staggered.If they were not, there would be a weak spot running right across the collagen fibre.What is the meaning of staggered ends here? Why would there be a weak spot running right across the collagen fibre if the ends are not staggered? Thank you ...
It is caused by a different toxin (beta-aminopropionitrile), which affects the linking of collagen, a protein of connective ... It is also caused by the toxin beta-aminopropionitrile. Eating the chickling pea with grain having high concentrations of ... It is caused by the toxin beta-aminopropionitrile which inhibits the copper-containing enzyme lysyl oxidase, responsible for ... which is similar to osteolathyrism in its effects on connective tissue by means of the toxin beta-aminopropionitrile. However, ...
It is prepared by the amination of acrylonitrile followed by hydrogenation of the resulting aminopropionitrile. The potassium ...
... modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile". Osteoarthritis and ...
They went on to explore how aminopropionitrile in sweet peas could be bound with polymers, and created CryoSkin. They were ...
It is caused by a different toxin (beta-aminopropionitrile) which affects the linking of collagen, a protein of connective ... The cause of this disease is attributed to beta-aminopropionitrile, which inhibits the copper-containing enzyme lysyl oxidase, ... It is a skeletal disorder, caused by the toxin beta-aminopropionitrile (BAPN), and characterized by hernias, aortic dissection ...
The most widely-studied of these compounds is beta-aminopropionitrile (BAPN), which exerts its deleterious effect by an unknown ... beta-aminopropionitrile), which affects the linking of collagen, a protein of connective tissues. The condition results in ...
The main chemical responsible is β-Aminopropionitrile, which prevents collagen cross-linking, thus making the blood vessel, ...
Seeds of the sweet pea contain beta-aminopropionitrile that prevents the cross-linking of collagen by inhibiting lysyl oxidase ...
The molecular formula C3H6N2 may refer to: Aminopropionitrile (BAPN) Dihydroimidazol-2-ylidene Imidazolines 2-Imidazoline ...
... combinations QM01AX90 Pentosan polysulfate QM01AX91 Aminopropionitrile QM01AX92 Grapiprant QM01AX99 Combinations M01BA01 ...
... amino]propionitrile) and any salt thereof Mefenorex (d,l-N-(3-chloropropyl)-α-methylbenzeneethanamine) and any salt thereof ...
... lysyl oxidase was inhibited either by nutritional copper-deficiency or by supplementation of diets with β-aminopropionitrile ( ...
Fenproporex ((±)-3-[(alpha-methylphenylethyl)amino]propionitrile). *Fludiazepam (7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1- ...
... , also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional ... Beta-amino-propionitrile (BAPN) found in lathyrus odoratus (common garden sweet pea) is thought to be responsible for ... Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile. Kashin-Beck disease Lysyl oxidase Marfan syndrome ... "Aminopropionitrile - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. ...
Superoxide is one of the main reactive oxygen species in the cell. As a consequence, SOD serves a key antioxidant role. The physiological importance of SODs is illustrated by the severe pathologies evident in mice genetically engineered to lack these enzymes. Mice lacking SOD2 die several days after birth, amid massive oxidative stress.[26] Mice lacking SOD1 develop a wide range of pathologies, including hepatocellular carcinoma,[27] an acceleration of age-related muscle mass loss,[28] an earlier incidence of cataracts, and a reduced lifespan. Mice lacking SOD3 do not show any obvious defects and exhibit a normal lifespan, though they are more sensitive to hyperoxic injury.[29] Knockout mice of any SOD enzyme are more sensitive to the lethal effects of superoxide-generating compounds, such as paraquat and diquat (herbicides). Drosophila lacking SOD1 have a dramatically shortened lifespan, whereas flies lacking SOD2 die before birth. SOD knockdowns in the worm C. elegans do not cause major ...
In the US, ketorolac is the only widely available intravenous NSAID. An IV form of paracetamol, which is not an NSAID, became available in Europe in 2009 and then in the US.[13] The Syntex company, of Palo Alto, California developed the ophthalmic solution Acular[25] around 2006, which is currently licensed by Allergan, Inc.[26][27] In 2007, there were concerns about the high incidence of reported side effects. This led to restriction in its dosage and maximum duration of use. In the UK, treatment was initiated only in a hospital, although this was not designed to exclude its use in prehospital care and mountain rescue settings.[1] Dosing guidelines were published at that time.[28] Concerns over the high incidence of reported side effects with ketorolac trometamol led to its withdrawal (apart from the ophthalmic formulation) in several countries, while in others its permitted dosage and maximum duration of treatment have been reduced. From 1990 to 1993, 97 reactions with a fatal outcome were ...
Machine translation like Deepl or Google Translate is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia ...
... is an organic compound, which, especially in its ester form, is called fenamate.[1]:458 serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. These drugs are commonly referred to as "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid.[2]:235[3]:17[2] ...
... (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1] ...
The VIGOR (Vioxx GI Outcomes Research) study, conducted by Bombardier, et al., which compared the efficacy and adverse effect profiles of rofecoxib and naproxen, had indicated a significant 4-fold increased risk of acute myocardial infarction (heart attack) in rofecoxib patients when compared with naproxen patients (0.4% vs 0.1%, RR 0.25) over the 12-month span of the study. The elevated risk began during the second month on rofecoxib. There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. The difference in overall risk was by the patients at higher risk of heart attack, i.e. those meeting the criteria for low-dose aspirin prophylaxis of secondary cardiovascular events (previous myocardial infarction, angina, cerebrovascular accident, transient ischemic attack, or coronary ...
Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionised. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion.[152][153][154] About 50-80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1-0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.[154] As much as 80% of therapeutic doses of salicylic acid is ...
The COX-2 enzyme was discovered in 1988 by Daniel Simmons, a Brigham Young University researcher.[23] The mouse COX-2 gene was cloned by UCLA scientist Dr. Harvey Herschman, a finding published in 1991.[24]. The basic research leading to the discovery of COX-2 inhibitors has been the subject of at least two lawsuits. Brigham Young University has sued Pfizer, alleging breach of contract from relations BYU had with the company at the time of Dr. Simmons's work.[25][26] A settlement was reached in April 2012 in which Pfizer agreed to pay $450 million.[27][28] The other litigation is based on United States Pat. No. 6,048,850[29] owned by University of Rochester, which claimed a method to treat pain without causing gastro-intestinal distress by selectively inhibiting COX-2. When the patent issued, the university sued Searle (later Pfizer) in a case called, University of Rochester v. G.D. Searle & Co., 358 F.3d 916 (Fed. Cir. 2004). The court ruled in favor of Searle in 2004, holding in essence that ...
... is a nonsteroidal anti-inflammatory drug (NSAID). Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the US as Nalfon. As of 2015 the cost for a typical month of medication in the United States is 50 to US$100.[1] ...
... was available over-the-counter in the United States in the form of 12.5 mg coated tablets (Orudis KT and Actron), but this form has been discontinued. It is available by prescription capsules. Ketoprofen is also available as a 2.5% gel for topical application, and it is also available as a patch for topical analgesia and anti-inflammatory action. However, the gel is not sold in the United States. Brand names in Australia are Orudis and Oruvail. It is available in Japan in a transdermal patch Mohrus Tape, made by Hisamitsu Pharmaceutical. It is available in the UK as Ketoflam and Oruvail, in Ireland as Fastum Gel, in Estonia as Keto, Ketonal, and Fastum Gel, in Finland as Ketorin, Keto, Ketomex, and Orudis; in France as Profénid, Bi-Profénid and Ketum; in Italy as Ketodol, Fastum Gel, Lasonil, Orudis and Oki; in Poland, Serbia, Slovenia and Croatia as Knavon and Ketonal; in Romania as Ketonal and Fastum Gel; in Mexico as Arthril; in Norway as Zon and Orudis; in Russia as ОКИ ...
... (Gewodin, Gewolen) is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.[1][2][3] It has analgesic, anti-inflammatory, and antipyretic effects.[1][2] Famprofazone has been known to produce methamphetamine as an active metabolite, with 15-20% of an oral dose being converted to it.[4][5] As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.[3] ...
ImSAIDs are a class of peptides being developed by IMULAN BioTherapeutics, LLC, which were discovered to have diverse biological properties, including anti-inflammatory properties. ImSAIDs work by altering the activation and migration of inflammatory cells, which are immune cells responsible for amplifying the inflammatory response.[11][12] The ImSAIDs represent a new category of anti-inflammatory and are unrelated to steroid hormones or nonsteroidal anti-inflammatories. The ImSAIDs were discovered by scientists evaluating biological properties of the submandibular gland and saliva. Early work in this area demonstrated that the submandibular gland released a host of factors that regulate systemic inflammatory responses and modulate systemic immune and inflammatory reactions. It is now well accepted that the immune, nervous, and endocrine systems communicate and interact to control and modulate inflammation and tissue repair. One of the neuroendocrine pathways, when activated, results in the ...
InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1 ...
... was first synthesized in 1815 by Joseph Louis Gay-Lussac, who determined its empirical formula and named it. Gay-Lussac coined the word "cyanogène" from the Greek words κυανός (kyanos, blue) and γεννάω (gennao, I create), because cyanide was first isolated by the Swedish chemist Carl Wilhelm Scheele from the pigment "Prussian blue".[14] By the 1850s, cyanogen soap was used by photographers to remove silver stains from their hands.[15] It attained importance with the growth of the fertilizer industry in the late 19th century and remains an important intermediate in the production of many fertilizers. It is also used as a stabilizer in the production of nitrocellulose. In 1910 a spectroscopic analysis of Halley's Comet found cyanogen in the comet's tail, which led to public fear that the Earth would be poisoned as it passed through the tail. Because of the extremely diffuse nature of the tail, there was no effect when the planet passed through it.[16][17]. ...
Ang Mefenamic acid o Asidong mefenamiko ay isang miyembro ng klaseng deribatibong asidong anthraniliko (o fenamate) ng mga gamot NSAID. Kadalasan itong ginagamit na panlunas sa kaunti hanggang katamtamang kirot, kasama na ang kirot dulot ng sapanahon o pagreregla, at ginagamit rin para malunasan ang mga sakit ng ulo na kaugnay ng pagreregla.[1][2] Hindi ito malawakang ginagamit dahil sa mga naitatalang kasamang epekto.[3][4]:334 Natuklasan at naibenta ito sa pamilihan ng Parke-Davis noong dekada ng 1960 sa ilalim ng pangalang Ponstan, Ponalar, Ponstyl, at Ponstel. Naging heneriko ito noong dekada ng 1980 at nagagamit na sa buong mundo sa ilalim ng ibat-ibang pangalan..[5] Noong 2015, mahigit 200 USD ang halaga ng medikasyon ng mefenamic acid sa Estados Unidos.[6] ...
Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional ... Beta-amino-propionitrile (BAPN) found in lathyrus odoratus (common garden sweet pea) is thought to be responsible for ... Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile. Kashin-Beck disease Lysyl oxidase Marfan syndrome ... "Aminopropionitrile - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. ...
Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol. Takehito Sasaki and Masahiko ... Young mice chronically treated with β-aminopropionitrile (BAPN) were subsequently given injections of graded doses of ... Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol ... Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol ...
CH$NAME: 3-Aminopropionitrile. CH$NAME: 3-Aminopropiononitrile. CH$NAME: beta-Aminopropionitrile. CH$COMPOUND_CLASS: N/A. CH$ ... 3-Aminopropionitrile; LC-ESI-QQ; MS2; CE:50 V; [M+H]+. Mass Spectrum ... RECORD_TITLE: 3-Aminopropionitrile; LC-ESI-QQ; MS2; CE:50 V; [M+H]+. DATE: 2016.01.19 (Created 2007.07.07, modified 2011.05.10) ... 3-Aminopropionitrile with the InChIKey AGSPXMVUFBBBMO-UHFFFAOYSA-N. ...
Metabolite mapped to [1647] 3-aminopropionitrile 2 [9.927]. metabolite. stereoisomer. isotopomer. 3-aminopropionitrile. ambient ... Details of [1647] 3-aminopropionitrile 2 [9.927]. rotate: click+drag; translate: alt. +click+drag; zoom: mousewheel; save: mol ... Reference spectra of [1647] 3-aminopropionitrile 2 [9.927]. replica. entry date. detection. method. species. ... Synonyms of [1647] 3-aminopropionitrile 2 [9.927]. property. value. Manual Interpretation [JKopka]. Proprionitril, 3-amino- ( ...
Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism. D. Kumar, M. B. Trent, P. J. Boor ... Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism. Toxicology. 1998 Feb 6;125(2-3): ... Allylamine and β-aminopropionitrile induced aortic medial necrosis : Mechanisms of synergism. / Kumar, D.; Trent, M. B.; Boor, ... Kumar, D. ; Trent, M. B. ; Boor, P. J. / Allylamine and β-aminopropionitrile induced aortic medial necrosis : Mechanisms of ...
To examine the role of LOX, some rats were fed food containing 0.12% β-aminopropionitrile (BAPN) (Tokyo Chemicals), a LOX ... Treatment with the LOX inhibitor β-aminopropionitrile resulted in enhanced progression of CA. Expression of procollagen type I ... Induction of Experimental CAs in Rats and β-Aminopropionitrile Treatment. Animal experiments complied with Japanese community ...
Product name: Ciprofloxacin hydrochloride CAS No.:86393-32-0 Molecular formula: C17H18FN3O3HCl Appearance: Faintly yellowish to light yellow crystals Residue on ignition: 0.1% Sulfate: 0.04% Heavy Metals: 20ppm Ph: 3.0-4.5 Water: 4.7% - 6.7
Aminopropionitrile. Tunica Media--drug effects. Chick Embryo--anatomy & histology. Academic Dissertations Collection MUSC ... Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick ... Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick ... Post a Comment for Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of ...
[email protected]#To establish the mouse aorta dissection (AD) model through drinking water containing β-aminopropionitrile (BAPN)[email protected]* ... Establishment of β-aminopropionitrile-induced aortic dissection model in C57Bl/6J mice / 中华心血管病杂志 ... Establishment of β-aminopropionitrile-induced aortic dissection model in C57Bl/6J m ...
beta-Aminopropionitrile. *2-Cyanoethylamine. *3-Aminopropanenitrile. *3-Aminopropionitrile. *3-Aminopropiononitrile. * ...
Then a lathyrogenic agent, preferably D-penicillinamine or Beta-aminopropionitrile (BAPN), or Beta-aminopropionitrile fumarate ... b) applying B-aminopropionitrile fumarate onto a catheter;. c) inserting the catheter into the tubular body portion for a ... 5. The method defined in claim 1 wherein the lathyrogenic agent is B-aminopropionitrile fumarate. ... 4 (October 1972). However, serious toxicity problems were encountered with systemically introduced Beta-aminopropionitrile ...
ibuprofen, beta amino propionitrile, and steroids;. - references:. - Effects of Nonsteroidal Anti-Inflammatory Drugs on Flexor ...
Rapamycin has been shown to attenuate fibrosis in the kidney and the liver [82, 83]. β-aminopropionitrile (BAPN) may suppress ...
Narodne novine d.d se obvezuju poštivati anonimnost i privatnost korisnika ovih internetskih stranica. O posjetiteljima se neće prikupljati nikakvi osobni podaci osim u slučajevima ako ih posjetitelj dobrovoljno dostavi Narodnim novinama d.d. U slučajevima kad je poznat indentitet posjetitelja/pošiljatelja, njegovi će se podaci koristiti samo u svrhu zbog koje ih je pošiljatelj poslao. Narodne novine d.d. takve podatke mogu koristiti i za što bolji uvid i razumijevanja pojedinačnih potreba i zahtjeva korisnika kao i razvijanja mogućnosti što kvalitetnijega pružanja svojih usluga korisnicima. Narodne novine d.d. se obvezuju da navedene podatke neće učiniti dostupnim bilo kojoj trećoj osobi odnosno strani bez izričitoga pristanka korisnika ...
3-[Benzyl-(3,5-dimethyl-pyrazol-1-ylmethyl)-amino]-propionitrile. Previous Article in Journal. 1-{[Benzyl-(2-cyano-ethyl)-amino ...
Konzo and lathyrism are associated with consumption of cassava and grass pea, respectively. Cassava consumption has also been associated with a third disease, tropical ataxic neuropathy (TAN). This review presents a new unifying hypothesis on the causative agents for these diseases: namely, that the …
Aminopropionitrile Related Therapies and Procedures. 1. Prostheses and Implants (Prosthesis) 2. Transplants (Transplant) ...
ß-aminopropionitrile ベータアミノプロピオニトリル lathyrogen ラチロゲン bone development 骨発生 skeletal deformity 骨格変形 ... Characterization of skeletal deformities of chick embryo induced by administration of ß-aminopropionitrile. ...
It is caused by a different toxin (beta-aminopropionitrile), which affects the linking of collagen, a protein of connective ... It is also caused by the toxin beta-aminopropionitrile. Eating the chickling pea with grain having high concentrations of ... It is caused by the toxin beta-aminopropionitrile which inhibits the copper-containing enzyme lysyl oxidase, responsible for ... which is similar to osteolathyrism in its effects on connective tissue by means of the toxin beta-aminopropionitrile. However, ...
Reversal by b-aminopropionitrile and D-penicillamine. Diabetes, New York, v.29, n.10, p.778-781, 1980. [ Links ]. CHEN, Y., ...
Reduction of chronic hypoxic pulmonary hypertension in the rat by β-aminopropionitrile. J Appl Physiol Respir Environ Exerc ... In parallel but in separate rat cohorts, 1 day after monocrotaline injection, β-aminopropionitrile (BAPN; 100 mg/kg/d; Sigma- ... First, using a known pharmacologic inhibitor (β-aminopropionitrile, BAPN) of lysyl oxidase (Lox), the enzyme responsible for ... Reduction of blood pressure and vascular collagen in hypertensive rats by beta-aminopropionitrile. Proc Natl Acad Sci U S A. ...
Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection ... Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection. ...
Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection ... Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection. ...
At 65-70℃/(8.0-14.7kPa), decrease the pressure to recover t-butanol to obtain crude beta-aminopropionitrile. Distill the crude ... Acrylonitrile and ammonia react in a solution of diphenylamine and t-butanol to create beta-aminopropionitrile, which is then ... This method requires 982kg beta-aminopropionitrile for every ton of product, and the yield of alkalization is 90%. ... product under low pressure, collect the 66-105℃/(1.33-4.0kPa) distillation to obtain beta-aminopropionitrile, and maintain ...
Beta-Aminopropionitrile-induced dissecting aneurysms of turkeys: treatment with propranolol. Toxicol Appl Pharmacol 1970;16:143 ... Influence of d-,l- and dl-propranolol, and practolol on beta-amino-propionitrile-induced aortic ruptures of turkeys. Toxicol ...
dimethyl amino-propionitrile (DMAP) or N,N,N. ,N. ,- tetramethylethylenediamine (TEMED). The gels are neutral, hydrophillic, ...
The compounds tested included beta-aminopropionitrile (151188) (BAPN), 3,3- dimethylaminopropionitrile (DMAPN), 3,3- ... The compounds tested included beta-aminopropionitrile (151188) (BAPN), 3,3- dimethylaminopropionitrile (DMAPN), 3,3- ...
1991). Purkinje cell toxicity of beta-aminopropionitrile in the rat. Virchows Arch. A Pathol. Anat. Histopathol. 419, 403-408. ... 1983). Reaction of aortic lysyl oxidase with beta-aminopropionitrile. J. Biol. Chem. 258, 4331-4338. ...
Differential effects of homocysteine and beta aminopropionitrile on preosteoblastic MC3T3-E1 cells. Bone 2010;46(3):703-9. doi ...
  • Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional groups. (wikipedia.org)
  • Young mice chronically treated with β-aminopropionitrile (BAPN) were subsequently given injections of graded doses of isoproterenol, and the response of various tissues to IPR in synthesizing DNA was analyzed. (aacrjournals.org)
  • To examine the role of LOX, some rats were fed food containing 0.12% β-aminopropionitrile (BAPN) (Tokyo Chemicals), a LOX inhibitor. (ahajournals.org)
  • [email protected]#To establish the mouse aorta dissection (AD) model through drinking water containing β- aminopropionitrile ( BAPN ). (bvsalud.org)
  • However, treatment of mice with β-aminopropionitrile (BAPN), an inhibitor of matrix cross-linking enzymes, induced subclinical POP. (jci.org)
  • In parallel, RRECs were grown in HG medium and transfected with LOX small interfering RNA (siRNA), scrambled siRNA as control, or exposed to β-aminopropionitrile (BAPN), a LOX inhibitor. (arvojournals.org)
  • Weanling Sprague-Dawley rats received beta-aminopropionitrile (BAPN) and/or hypertensive treatment, namely, heminephrectomy and administration of deoxycorticosterone acetate-NaCl. (researchmap.jp)
  • Using 3-aminopropionitrile fumarate (BAPN)- and angiotensin II (Ang II)-induced AAD animal models, inhibition of ALDH2 was found to retard development of AAD. (onmedica.com)
  • In this study, we used genipin or beta-Aminopropionitrile (BAPN) agents to induce or inhibit matrix cross-linking, respectively, to investigate the effects on outflow resistance and ECM remodeling. (elsevier.com)
  • Female Sprague-Dawley rats (n=6, age 87 days) were injected twice daily for 43 days with #-aminopropionitrile (BAPN, 333 mg/kg/day i.p.), an inhibitor of lysyl oxidase, which is responsible for the production of collagen cross-links. (cdc.gov)
  • Disruption of the ECM by preventing collagen deposition using the lathrytic agent β-aminopropionitrile (BAPN) inhibits LpS1 gene transcription. (elsevier.com)
  • The PET experiments were carried out in the presence or absence of β-aminopropionitrile (BAPN), an irreversible inhibitor of LOX. (biomedcentral.com)
  • Treatment with the LOX inhibitor β-aminopropionitrile resulted in enhanced progression of CA. Expression of procollagen type I, III, and LOX was inhibited by interleukin-1β (IL-1β) in cultured rat aortic smooth muscle cells (RASMCs) in vitro. (ahajournals.org)
  • It is caused by a different toxin (beta-aminopropionitrile), which affects the linking of collagen, a protein of connective tissues. (wikipedia.org)
  • All of the haplotype variants of LOXL1 (141R-153G, 141R-153D, 141L-153G, and 141L-153D) showed β-aminopropionitrile-inhibitable amine oxidase activity toward elastin, type I collagen, and cadaverine, indicating that each LOXL1 variant functions as an amine oxidase. (molvis.org)
  • For example, Riley et al have prevented fibrosis in animal models by administering either proline analogues, which interfere with proper folding of collagen, or beta-aminopropionitrile, which interferes with collagen crosslinking. (cdc.gov)
  • We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. (utmb.edu)
  • A TAI animal model was induced by orally administering ß-aminopropionitrile to rats for 6 weeks. (bvsalud.org)
  • It is caused by the toxin beta-aminopropionitrile which inhibits the copper-containing enzyme lysyl oxidase, responsible for cross-linking procollagen and proelastin. (wikipedia.org)
  • A. Sampath Narayanan, R. C. Siegel, and G. R. Martin, "On the inhibition of lysyl oxidase by β -aminopropionitrile," Biochemical and Biophysical Research Communications , vol. 46, no. 2, pp. 745-751, 1972. (hindawi.com)
  • Parmi ces gènes, je me suis intéressée à un membre de la famille des lysyl oxydases, LOXL4, qui joue un rôle clé dans la dynamique de la matrice extracellulaire en régulant la réticulation du collagène. (archives-ouvertes.fr)
  • ß-aminopropionitrile blocked crosslinking ECM in aorta to cause structural alteration with inflammation within 1 week and then, induced aortic dissection within 4 weeks of initiating treatment, leading to mortality within 6 weeks. (bvsalud.org)
  • The research team identified a compound, 3-aminopropionitrile, that inhibits the enzyme that causes graft contraction and combined it with a biocompatible polymer gel invented by chemist Steve Armes, also at Sheffield. (cosmeticsandtoiletries.com)
  • 5. The method defined in claim 1 wherein the lathyrogenic agent is B-aminopropionitrile fumarate. (google.com)
  • Tritiated ß-aminopropionitrile was diffusely distributed throughout bone and was completely removed by saline extraction. (rupress.org)
  • Importantly, treatment of GATA-1(low) mice with beta-aminopropionitrile significantly improves the bone marrow fibrotic phenotype, and MK number in the spleen. (luriechildrens.org)
  • Available data included measurements of tissue volume, biochemical composition, and tensile modulus for bovine calf articular cartilage (AC) explants harvested at three depths and incubated for 13 days in 20% fetal borine serum (FBS) and 20% FBS+ ß-aminopropionitrile. (calpoly.edu)
  • Another type of lathyrism is angiolathyrism, which is similar to osteolathyrism in its effects on connective tissue by means of the toxin beta-aminopropionitrile. (wikipedia.org)
  • It is also caused by the toxin beta-aminopropionitrile. (wikipedia.org)
  • LOX inhibition with beta-aminopropionitrile reduces PDGFR-BB binding to cells and downstream signaling, as well as its proliferative effect on the MK lineage. (luriechildrens.org)
  • Then, the inhibition of the LOXL4 protein in scratch assay experiments (using β-aminopropionitrile or a specific siRNA) allowed us to demonstrate that the pro-healing effect of atRA was mediated, at least in part, by the retinoid-induction of this gene. (archives-ouvertes.fr)
  • Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick aorta : a mongraphic study by Susan Averill Taylor. (musc.edu)
  • Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile. (wikipedia.org)
  • Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica. (musc.edu)
  • Acrylonitrile and ammonia react in a solution of diphenylamine and t-butanol to create beta-aminopropionitrile, which is then alkalized to obtain beta-aminopropionic acid. (lookchem.com)
  • Differential effects of homocysteine and beta aminopropionitrile on preosteoblastic MC3T3-E1 cells. (scienceopen.com)
  • Some species of lathyrus, notably Lathyrus odoratus, are unable to induce human lathyrism but contain a compound, beta-aminopropionitrile (BAPN), that induces pathological changes in bone ('osteolathyrism') and blood vessels ('angiolathyrism') of experimental animals without damaging the nervous system. (elsevier.com)
  • To determine the effects of LOX enzymatic activity in ccRCC, Caki-2 cells were treated with increasing concentrations of beta-aminopropionitrile (BAPN), and cell proliferation, migration, invasion and apoptosis were assessed in vitro . (ncri.org.uk)
  • A paralytic condition of the legs caused by ingestion of lathyrogens, especially BETA-AMINOPROPIONITRILE or beta-N-oxalyl amino-L-alanine, which are found in the seeds of plants of the genus LATHYRUS. (wakehealth.edu)