Aminopropionitrile
Metabolome
Metabolomics
Guanosine Diphosphate Fucose
Guanosine Diphosphate Sugars
Guanosine Diphosphate Mannose
Prostatic Intraepithelial Neoplasia
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Allylamine
Necrosis
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Tunica Media
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
Rats, Sprague-Dawley
Collagen
Procollagen
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
Collagen Type I
Intracranial Aneurysm
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
Cell Wall
Cystatin C
United States Food and Drug Administration
Device Approval
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
Eligibility Determination
Book Industry
Lathyrism
Azetidinecarboxylic Acid
Protein-Lysine 6-Oxidase
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
gamma-Glutamyltransferase
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The smooth muscle cell. III. Elastin synthesis in arterial smooth muscle cell culture. (1/87)
Primate arterial smooth muscle cells and skin fibroblasts were examined for their ability to synthesize elastin in culture. In the presence of the lathyrogen beta-aminopropionitrile, the smooth muscle cells incorporate [3H]lysine into a lysyl oxidase substrate that was present in the medium and associated with the cell layer. A component having a mol wt of 72,000 and an electrophoretic mobility similar to that of authentic tropoelastin was isolated from the labeled smooth muscle cells by coacervation and fractionation with organic solvents. In the absence of beta-aminopropionitrile, long-term cultures of smooth muscle cells incorporated [14C]lysine into desmosine and isodesmosine, the cross-link amino acids unique to elastin. In contrast, no desmosine formation occurred in the fibroblast cultures. These characteristics demonstrate that arterial smooth muscle cells are capable of synthesizing both soluble and cross-lined elastin in culture. (+info)Lysyl oxidase activates the transcription activity of human collagene III promoter. Possible involvement of Ku antigen. (2/87)
Lysyl oxidase is an extracellular enzyme that controls the maturation of collagen and elastin. Lysyl oxidase and collagen III often show similar expression patterns in fibrotic tissues. Therefore, we investigated the influence of lysyl oxidase overexpression on the promoter activity of human COL3A1 gene. Our results showed that when COS-7 cells overexpressed the mature form of lysyl oxidase, the activity of the human COL3A1 promoter was increased up to an average of 12 times when tested by luciferase reporter assay. The effect was specific, because other promoters were not affected. Moreover, lysyl oxidase effect was abolished by beta-aminopropionitrile, a specific inhibitor of its catalytic activity. Electrophoretic mobility shift assay showed a binding activity in the region from -101 to -77 that was significantly increased by lysyl oxidase overexpression. The binding was specifically competed by the cold probe, and the mutagenesis of this region abolished both the binding activity in gel retardation and lysyl oxidase stimulation of COL3A1 promoter in transfection experiments. We identified the binding activity as Ku antigen in its two components: Ku80 and Ku70. This study suggests a new coordinated mechanism by which lysyl oxidase might control the development of fibrosis. (+info)Collagen synthesis in capsules surrounding dimethylbenzanthracene-induced rat breast tumors and the effect of pretreatment with beta-aminopropionitrile. (3/87)
Collagen synthesis is increased over three-fold in capsules surrounding dimethylbenzanthracene-induced rat breast tumors compared to the tumor parenchyma and over six-fold compared to normal breast connective tissue. Increased collagen synthesis is independent of the rate of tumor growth and final tumor size. Pretreatment of animals with beta-aminopropionitrile to inhibit collagen cross-linking caused an 82% decrease in tumor formation and a significant reduction in tumor volume (approximately 0.4 cu cm) compared to controls (approximately 10 cu cm). The four small tumors that did develop in the lathyritic animals had increased collagen synthesis in the interior tumor stroma and reduced collagen synthesis in the tumor capsule. These findings suggest that the collagenous capsule surrounding dimethylbenzanthracene tumors functions as a physical barrier to protect the tumor from the immune system of the host. The apparent antitumor effects of beta-aminopropionitrile may be due to immunopotentiation and/or cytotoxic actions of the drug. (+info)Analysis of the combined osteolathyritic effects of beta-aminopropionitrile and diethyldithiocarbamate on xenopus development. (4/87)
In order to examine the mechanistic basis between combined effects and mechanisms of action, two osteolathyrogens, beta-aminopropionitrile (betaAPN) and diethyldithiocarbamate (DTC), were tested together on Xenopus embryos. In a separate test, DTC was also tested with copper sulfate to determine the importance of copper in DTC-induced osteolathyrism. Frog embryos (Xenopus laevis) were exposed for 96 h, with daily solution removal and replacement. Preserved tadpoles were evaluated for osteolathyritic lesions. For the betaAPN:DTC test, a 1.2-factor matrix design was used, producing two single chemical and seven mixture-response curves. The chi(2) goodness-of-fit test was used to compare the experimental mixture-response curves with theoretical effects for two combined effects models, dose-addition and independence. All seven mixture curves were consistent with expected results for dose-addition, but the correlations were generally not high. For the DTC:copper test, the three mixture-response curves generated showed that added copper increased the DTC-alone EC(50), but there was no corresponding right shift at the top of the response curves, as observed previously with betaAPN and copper. In the betaAPN:DTC and DTC:copper tests, DTC alone showed a biphasic concentration-osteolathyrism curve, and the slope of the response curve for DTC alone in each test was statistically different than the slope for the betaAPN alone response curve. Taken together, the results suggest the potential for a second osteolathyritic effect of DTC that affected the combined toxicity enough to produce a dose-addition correlation without the chemicals necessarily having the same mechanism. (+info)Amine oxidase-like activity of polyphenols. Mechanism and properties. (5/87)
Polyphenols in several oxidation systems gained amine oxidase-like activity, probably due to the formation of the corresponding quinones. In the presence of Cu(II), o- and p-phenolic compounds exhibited amine oxidase-like activity, whereas only the o-phenolic compounds showed the activity in the presence of 1,1-diphenyl-2-picrylhydrazyl radical. The activity was determined by measuring the conversion of benzylamine to benzaldehyde by HPLC. Moreover, gallic acid, chlorogenic acid, and caffeic acid, which are plant polyphenols, converted the lysine residue of bovine serum albumin to alpha-amino-adipic semialdehyde residue, indicating lysyl oxidase-like activity. We also characterized the activity of pyrocatechol, hydroquinone, and pyrogallol in the presence of Cu(II). The oxidative deamination was accelerated at a higher pH, and required O2 and transition metal ions. Furthermore, EDTA markedly inhibited the reaction but not beta-aminopropionitrile, which is a specific inhibitor of lysyl oxidase. Catalase significantly inhibited the oxidation, implying the participation of hydroxyl radical in the reaction, but superoxide dismutase stimulated the oxidation, probably due to its radical formation activity. We discussed the mechanism of the oxidative deamination by polyphenols and the possible significance of the activity for biological systems. (+info)The effect of beta aminoproprionitrile (BAPN) on experimental amyloidosis. (6/87)
Experimental amyloidosis was induced in mice with repeated injections of complete Freund's adjuvant (CFA) reinforced with bacterial vaccine. BAPN administered in a mixture with CFA or on its own before the injection of CFA reduced the incidence of amyloidosis. The reduction in the incidence of amyloidosis following the administration of BAPN may be due to its inhibitory effect on the oxidative deamination of amino acids, which presumably inhibit cross-linking of amyloid fibrils or interfere with metabolic pathways which involve the formations of mucopolysaccharide formation. It is suggested that the defective formation of the mucopolysaccharide-amyloid protein complex inhibits amyloid deposition and induces the activity of beta glucuronidase observed in the present study. The reduced incidence of amyloidosis following BAPN adminsitration cannot be due to lysosomal enzyme degradation of the amyloid as the activity of cathepsin D and acid phosphatase is decreased during this process. (+info)A molecular role for lysyl oxidase in breast cancer invasion. (7/87)
We identified previously an up-regulation in lysyl oxidase (LOX) expression,an extracellular matrix remodeling enzyme, in a highly invasive/metastatic human breast cancer cell line, MDA-MB-231, compared with MCF-7, a poorly invasive/nonmetastatic breast cancer cell line. In this study, we demonstrate that the mRNA expression of LOX and other LOX family members [lysyl oxidase-like (LOXL), LOXL2, LOXL3, and LOXL4] was observed only in breast cancer cells with a highly invasive/metastatic phenotype but not in poorly invasive/nonmetastatic breast cancer cells. LOX and LOXL2 showed the strongest association with invasive potential in both highly invasive/metastatic breast cancer cell lines tested (MDA-MB-231 and Hs578T). To determine whether LOX is directly involved in breast cancer invasion, LOX antisense oligonucleotides were transfected into MDA-MB-231 and Hs578T cells, and found to inhibit invasion through a collagen IV/laminin/gelatin matrix in vitro compared with LOX sense oligonucleotide-treated and untreated controls. In addition, treatment of MDA-MB-231 and Hs578T cells with beta-aminopropionitrile (an irreversible inhibitor of LOX enzymatic activity) decreased invasive activity. Conversely, MCF-7 cells transfected with the murine LOX gene demonstrated a 2-fold increase in invasiveness that was reversible by the addition of beta-aminopropionitrile in a dose-dependent manner. In addition, endogenous LOX mRNA expression was induced when MCF-7 cells were cultured in the presence of fibroblast conditioned medium or conditioned matrix, suggesting a role for stromal fibroblasts in LOX regulation in breast cancer cells. Moreover, the correlation of LOX up-regulation and invasive/metastatic potential was additionally demonstrated in rat prostatic tumor cell lines, and human cutaneous and uveal melanoma cell lines. These results provide substantial new evidence that LOX is involved in cancer cell invasion. (+info)An angiotensin-converting enzyme inhibitor, not an angiotensin II type-1 receptor blocker, prevents beta-aminopropionitrile monofumarate-induced aortic dissection in rats. (8/87)
OBJECTIVE: Cystic medial degeneration (CMD) is a histologic abnormality that is common in aortic diseases such as aortic dilation, aneurysm, or dissection. Although little is known about the mechanism underlying CMD, we have previously demonstrated that angiotensin II signaling via angiotensin II type 2 receptor (AT2R) plays a central role in apoptosis of vascular smooth muscle cells (VSMCs) occurring in CMD associated with Marfan syndrome. The aim of this study is to elucidate the role of angiotensin II signaling in THE pathogenesis of aortic diseases associated with CMD. METHOD: We investigated the effects of angiotensin-converting enzyme inhibitor (ACEI), temocapril (n = 15), angiotensin II receptor type-1 (AT1R) blocker, CS-866 (n = 15), and vehicle control (n = 17) on 0.25% beta-aminopropionitrile monofumarate (BAPN)-induced aortic dissection and histopathologic findings in a rat model. RESULTS: Temocapril significantly prevented aortic dissection (P <.05), CMD (P <.01), and VSMC apoptosis (P <.01) compared with vehicle control in BAPN-fed rats. However, CS-866 did not show any preventive effect. Reversed transcriptase-polymerase chain reaction demonstrated that expression of both AT1R and AT2R was detected in control rat aortas, and that AT2R expression was significantly upregulated in the aortas of BAPN-fed rats (P <.01). Blood pressure was significantly and equally lowered in both temocapril and CS-866 groups compared with control. CONCLUSIONS: Differential expression of angiotensin II receptors and AT2R signaling are involved in the pathogenesis of CMD and aortic dissection in BAPN-fed rats. ACEIs might be of clinical value for the prevention and treatment of aortic diseases related to CMD. (+info)
Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick...
JAIRO | ß-aminopropionitrile投与による鶏胚骨格異常の解析
Bioline International Official Site (site up-dated regularly)
GMD - [1647] 3-aminopropionitrile 2 [9.927]
Effects of induction and inhibition of matrix cross-linking on remodeling of the aqueous outflow resistance by ocular...
Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism<...
EXPERIMENTAL LATHYRISM | JCB
Anti-LOX / Lysyl Oxidase Antibody | Rabbit anti-Human Polyclonal | LSBio
Patent US5120322 - Method and apparatus for treatment of fibrotic lesions - Google Patents
Plus it
Studies Show That Olive Oil Benefits Our Heart and Mind
Salt-soluble elastin from lathyritic chicks | Biochemical Journal
The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer<...
Protein-lysine 6-oxidase
Patent US7208300 - Member of the lysyl oxidase gene family - Google Patents
LOX propeptide - NB110-41568B | acris-antibodies.com
Histochemical Evidence of Aldehyde Blocking Capacity of Lathyrogenic Agents<...
A dual-cell device designed as an oxidase mimic and its use for the study of oxidase-like nanozymes - Chemical Communications ...
Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction
Lysyl Oxidase-Like 2 (LOXL2) ELISA Kits
anti Lysyl Oxidase Like 3 LOXL3 - Journal for the International Association for Laboratory Learning and Technology
Plus it
The role of lysyl oxidase-like 1 DNA copy number variantsin exfoliation glaucoma
Lysyl oxidase‐like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression | The EMBO Journal
Poster Presentation - Events 4 You Limited
Pearl Izumi Elite Gel FF Cycling Glove - Mens - Backed by a 100% Satisfaction Guarantee | TriVillage.com
Lathyrism : Wheeless Textbook of Orthopaedics
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase?
Recombinant Human LOXL2 Protein, His-tagged LOXL2-272H - Creative BioMart
LOX Enzyme May Be Scleroderma Marker, Therapeutic Target, Study Says
Human bone collagen synthesis is a rapid, nutritionally modulated process<...
Medical Advisor Journals, Kyle J. Norton Site, Health Tips for Better Living and Living Health: Hormones
Fabrication of oxidase-like hollow MnCo2O4 nanofibers and their sensitive colorimetric detection of sulfite and l-cysteine -...
Lysyl oxidase interacts with AGEs signaling to modulate collagen synthesis in polycystic ovarian tissue
LOXL1 Polymorphism in Pseudoexfoliation Syndrome - Full Text View - ClinicalTrials.gov
What is meant by staggered ends in collagen molecules?
Lathyrism
It is caused by a different toxin (beta-aminopropionitrile), which affects the linking of collagen, a protein of connective ... It is also caused by the toxin beta-aminopropionitrile. Eating the chickling pea with grain having high concentrations of ... It is caused by the toxin beta-aminopropionitrile which inhibits the copper-containing enzyme lysyl oxidase, responsible for ... which is similar to osteolathyrism in its effects on connective tissue by means of the toxin beta-aminopropionitrile. However, ...
1,3-Diaminopropane
It is prepared by the amination of acrylonitrile followed by hydrogenation of the resulting aminopropionitrile. The potassium ...
Cartilage
... modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile". Osteoarthritis and ...
Sheila MacNeil
They went on to explore how aminopropionitrile in sweet peas could be bound with polymers, and created CryoSkin. They were ...
Neurolathyrism
It is caused by a different toxin (beta-aminopropionitrile) which affects the linking of collagen, a protein of connective ... The cause of this disease is attributed to beta-aminopropionitrile, which inhibits the copper-containing enzyme lysyl oxidase, ... It is a skeletal disorder, caused by the toxin beta-aminopropionitrile (BAPN), and characterized by hernias, aortic dissection ...
Osteolathyrism
The most widely-studied of these compounds is beta-aminopropionitrile (BAPN), which exerts its deleterious effect by an unknown ... beta-aminopropionitrile), which affects the linking of collagen, a protein of connective tissues. The condition results in ...
Angiolathyrism
The main chemical responsible is β-Aminopropionitrile, which prevents collagen cross-linking, thus making the blood vessel, ...
Sweet pea
Seeds of the sweet pea contain beta-aminopropionitrile that prevents the cross-linking of collagen by inhibiting lysyl oxidase ...
C3H6N2
The molecular formula C3H6N2 may refer to: Aminopropionitrile (BAPN) Dihydroimidazol-2-ylidene Imidazolines 2-Imidazoline ...
ATC code M01
... combinations QM01AX90 Pentosan polysulfate QM01AX91 Aminopropionitrile QM01AX92 Grapiprant QM01AX99 Combinations M01BA01 ...
Controlled Drugs and Substances Act
... amino]propionitrile) and any salt thereof Mefenorex (d,l-N-(3-chloropropyl)-α-methylbenzeneethanamine) and any salt thereof ...
Lysyl oxidase
... lysyl oxidase was inhibited either by nutritional copper-deficiency or by supplementation of diets with β-aminopropionitrile ( ...
Psikotropika bahasa Indonesia, ensiklopedia bebas
Fenproporex ((±)-3-[(alpha-methylphenylethyl)amino]propionitrile). *Fludiazepam (7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1- ...
Aminopropionitrile
... , also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional ... Beta-amino-propionitrile (BAPN) found in lathyrus odoratus (common garden sweet pea) is thought to be responsible for ... Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile. Kashin-Beck disease Lysyl oxidase Marfan syndrome ... "Aminopropionitrile - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. ...
Superoxide dismutase
Superoxide is one of the main reactive oxygen species in the cell. As a consequence, SOD serves a key antioxidant role. The physiological importance of SODs is illustrated by the severe pathologies evident in mice genetically engineered to lack these enzymes. Mice lacking SOD2 die several days after birth, amid massive oxidative stress.[26] Mice lacking SOD1 develop a wide range of pathologies, including hepatocellular carcinoma,[27] an acceleration of age-related muscle mass loss,[28] an earlier incidence of cataracts, and a reduced lifespan. Mice lacking SOD3 do not show any obvious defects and exhibit a normal lifespan, though they are more sensitive to hyperoxic injury.[29] Knockout mice of any SOD enzyme are more sensitive to the lethal effects of superoxide-generating compounds, such as paraquat and diquat (herbicides). Drosophila lacking SOD1 have a dramatically shortened lifespan, whereas flies lacking SOD2 die before birth. SOD knockdowns in the worm C. elegans do not cause major ...
Ketorolac
In the US, ketorolac is the only widely available intravenous NSAID. An IV form of paracetamol, which is not an NSAID, became available in Europe in 2009 and then in the US.[13] The Syntex company, of Palo Alto, California developed the ophthalmic solution Acular[25] around 2006, which is currently licensed by Allergan, Inc.[26][27] In 2007, there were concerns about the high incidence of reported side effects. This led to restriction in its dosage and maximum duration of use. In the UK, treatment was initiated only in a hospital, although this was not designed to exclude its use in prehospital care and mountain rescue settings.[1] Dosing guidelines were published at that time.[28] Concerns over the high incidence of reported side effects with ketorolac trometamol led to its withdrawal (apart from the ophthalmic formulation) in several countries, while in others its permitted dosage and maximum duration of treatment have been reduced. From 1990 to 1993, 97 reactions with a fatal outcome were ...
Succinonitrile
Machine translation like Deepl or Google Translate is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia ...
Fenamic acid
... is an organic compound, which, especially in its ester form, is called fenamate.[1]:458 serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. These drugs are commonly referred to as "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid.[2]:235[3]:17[2] ...
Benorilate
... (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1] ...
Rofecoxib
The VIGOR (Vioxx GI Outcomes Research) study, conducted by Bombardier, et al., which compared the efficacy and adverse effect profiles of rofecoxib and naproxen, had indicated a significant 4-fold increased risk of acute myocardial infarction (heart attack) in rofecoxib patients when compared with naproxen patients (0.4% vs 0.1%, RR 0.25) over the 12-month span of the study. The elevated risk began during the second month on rofecoxib. There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. The difference in overall risk was by the patients at higher risk of heart attack, i.e. those meeting the criteria for low-dose aspirin prophylaxis of secondary cardiovascular events (previous myocardial infarction, angina, cerebrovascular accident, transient ischemic attack, or coronary ...
Aspirin
Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionised. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion.[152][153][154] About 50-80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1-0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.[154] As much as 80% of therapeutic doses of salicylic acid is ...
COX-2 inhibitor
The COX-2 enzyme was discovered in 1988 by Daniel Simmons, a Brigham Young University researcher.[23] The mouse COX-2 gene was cloned by UCLA scientist Dr. Harvey Herschman, a finding published in 1991.[24]. The basic research leading to the discovery of COX-2 inhibitors has been the subject of at least two lawsuits. Brigham Young University has sued Pfizer, alleging breach of contract from relations BYU had with the company at the time of Dr. Simmons's work.[25][26] A settlement was reached in April 2012 in which Pfizer agreed to pay $450 million.[27][28] The other litigation is based on United States Pat. No. 6,048,850[29] owned by University of Rochester, which claimed a method to treat pain without causing gastro-intestinal distress by selectively inhibiting COX-2. When the patent issued, the university sued Searle (later Pfizer) in a case called, University of Rochester v. G.D. Searle & Co., 358 F.3d 916 (Fed. Cir. 2004). The court ruled in favor of Searle in 2004, holding in essence that ...
Fenoprofen
... is a nonsteroidal anti-inflammatory drug (NSAID). Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the US as Nalfon. As of 2015 the cost for a typical month of medication in the United States is 50 to US$100.[1] ...
Ketoprofen
... was available over-the-counter in the United States in the form of 12.5 mg coated tablets (Orudis KT and Actron), but this form has been discontinued. It is available by prescription capsules. Ketoprofen is also available as a 2.5% gel for topical application, and it is also available as a patch for topical analgesia and anti-inflammatory action. However, the gel is not sold in the United States. Brand names in Australia are Orudis and Oruvail. It is available in Japan in a transdermal patch Mohrus Tape, made by Hisamitsu Pharmaceutical. It is available in the UK as Ketoflam and Oruvail, in Ireland as Fastum Gel, in Estonia as Keto, Ketonal, and Fastum Gel, in Finland as Ketorin, Keto, Ketomex, and Orudis; in France as Profénid, Bi-Profénid and Ketum; in Italy as Ketodol, Fastum Gel, Lasonil, Orudis and Oki; in Poland, Serbia, Slovenia and Croatia as Knavon and Ketonal; in Romania as Ketonal and Fastum Gel; in Mexico as Arthril; in Norway as Zon and Orudis; in Russia as ОКИ ...
Famprofazone
... (Gewodin, Gewolen) is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.[1][2][3] It has analgesic, anti-inflammatory, and antipyretic effects.[1][2] Famprofazone has been known to produce methamphetamine as an active metabolite, with 15-20% of an oral dose being converted to it.[4][5] As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.[3] ...
Anti-inflammatory
ImSAIDs are a class of peptides being developed by IMULAN BioTherapeutics, LLC, which were discovered to have diverse biological properties, including anti-inflammatory properties. ImSAIDs work by altering the activation and migration of inflammatory cells, which are immune cells responsible for amplifying the inflammatory response.[11][12] The ImSAIDs represent a new category of anti-inflammatory and are unrelated to steroid hormones or nonsteroidal anti-inflammatories. The ImSAIDs were discovered by scientists evaluating biological properties of the submandibular gland and saliva. Early work in this area demonstrated that the submandibular gland released a host of factors that regulate systemic inflammatory responses and modulate systemic immune and inflammatory reactions. It is now well accepted that the immune, nervous, and endocrine systems communicate and interact to control and modulate inflammation and tissue repair. One of the neuroendocrine pathways, when activated, results in the ...
Thiocolchicoside
InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1 ...
Cyanogen
... was first synthesized in 1815 by Joseph Louis Gay-Lussac, who determined its empirical formula and named it. Gay-Lussac coined the word "cyanogène" from the Greek words κυανός (kyanos, blue) and γεννάω (gennao, I create), because cyanide was first isolated by the Swedish chemist Carl Wilhelm Scheele from the pigment "Prussian blue".[14] By the 1850s, cyanogen soap was used by photographers to remove silver stains from their hands.[15] It attained importance with the growth of the fertilizer industry in the late 19th century and remains an important intermediate in the production of many fertilizers. It is also used as a stabilizer in the production of nitrocellulose. In 1910 a spectroscopic analysis of Halley's Comet found cyanogen in the comet's tail, which led to public fear that the Earth would be poisoned as it passed through the tail. Because of the extremely diffuse nature of the tail, there was no effect when the planet passed through it.[16][17]. ...
Mefenamic acid, ang malayang ensiklopedya
Ang Mefenamic acid o Asidong mefenamiko ay isang miyembro ng klaseng deribatibong asidong anthraniliko (o fenamate) ng mga gamot NSAID. Kadalasan itong ginagamit na panlunas sa kaunti hanggang katamtamang kirot, kasama na ang kirot dulot ng sapanahon o pagreregla, at ginagamit rin para malunasan ang mga sakit ng ulo na kaugnay ng pagreregla.[1][2] Hindi ito malawakang ginagamit dahil sa mga naitatalang kasamang epekto.[3][4]:334 Natuklasan at naibenta ito sa pamilihan ng Parke-Davis noong dekada ng 1960 sa ilalim ng pangalang Ponstan, Ponalar, Ponstyl, at Ponstel. Naging heneriko ito noong dekada ng 1980 at nagagamit na sa buong mundo sa ilalim ng ibat-ibang pangalan..[5] Noong 2015, mahigit 200 USD ang halaga ng medikasyon ng mefenamic acid sa Estados Unidos.[6] ...
Aminopropionitrile - Wikipedia
Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional ... Beta-amino-propionitrile (BAPN) found in lathyrus odoratus (common garden sweet pea) is thought to be responsible for ... Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile. Kashin-Beck disease Lysyl oxidase Marfan syndrome ... "Aminopropionitrile - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. ...
Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol | Cancer Research
Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol. Takehito Sasaki and Masahiko ... Young mice chronically treated with β-aminopropionitrile (BAPN) were subsequently given injections of graded doses of ... Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol ... Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol ...
3-Aminopropionitrile Mass Spectrum
CH$NAME: 3-Aminopropionitrile. CH$NAME: 3-Aminopropiononitrile. CH$NAME: beta-Aminopropionitrile. CH$COMPOUND_CLASS: N/A. CH$ ... 3-Aminopropionitrile; LC-ESI-QQ; MS2; CE:50 V; [M+H]+. Mass Spectrum ... RECORD_TITLE: 3-Aminopropionitrile; LC-ESI-QQ; MS2; CE:50 V; [M+H]+. DATE: 2016.01.19 (Created 2007.07.07, modified 2011.05.10) ... 3-Aminopropionitrile with the InChIKey AGSPXMVUFBBBMO-UHFFFAOYSA-N. ...
GMD - [1647] 3-aminopropionitrile 2 [9.927]
Metabolite mapped to [1647] 3-aminopropionitrile 2 [9.927]. metabolite. stereoisomer. isotopomer. 3-aminopropionitrile. ambient ... Details of [1647] 3-aminopropionitrile 2 [9.927]. rotate: click+drag; translate: alt. +click+drag; zoom: mousewheel; save: mol ... Reference spectra of [1647] 3-aminopropionitrile 2 [9.927]. replica. entry date. detection. method. species. ... Synonyms of [1647] 3-aminopropionitrile 2 [9.927]. property. value. Manual Interpretation [JKopka]. Proprionitril, 3-amino- ( ...
Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism<...
Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism. D. Kumar, M. B. Trent, P. J. Boor ... Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism. Toxicology. 1998 Feb 6;125(2-3): ... Allylamine and β-aminopropionitrile induced aortic medial necrosis : Mechanisms of synergism. / Kumar, D.; Trent, M. B.; Boor, ... Kumar, D. ; Trent, M. B. ; Boor, P. J. / Allylamine and β-aminopropionitrile induced aortic medial necrosis : Mechanisms of ...
Reduced Collagen Biosynthesis Is the Hallmark of Cerebral Aneurysm | Arteriosclerosis, Thrombosis, and Vascular Biology
To examine the role of LOX, some rats were fed food containing 0.12% β-aminopropionitrile (BAPN) (Tokyo Chemicals), a LOX ... Treatment with the LOX inhibitor β-aminopropionitrile resulted in enhanced progression of CA. Expression of procollagen type I ... Induction of Experimental CAs in Rats and β-Aminopropionitrile Treatment. Animal experiments complied with Japanese community ...
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Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick...
Aminopropionitrile. Tunica Media--drug effects. Chick Embryo--anatomy & histology. Academic Dissertations Collection MUSC ... Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick ... Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick ... Post a Comment for Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of ...
Establishment of β-aminopropionitrile-induced aortic dissection model in C57Bl/6J mice | Chinese Journal of Cardiology;...
[email protected]#To establish the mouse aorta dissection (AD) model through drinking water containing β-aminopropionitrile (BAPN)[email protected]* ... Establishment of β-aminopropionitrile-induced aortic dissection model in C57Bl/6J mice / 中华心血管病杂志 ... Establishment of β-aminopropionitrile-induced aortic dissection model in C57Bl/6J m ...
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Patent US5120322 - Method and apparatus for treatment of fibrotic lesions - Google Patents
Then a lathyrogenic agent, preferably D-penicillinamine or Beta-aminopropionitrile (BAPN), or Beta-aminopropionitrile fumarate ... b) applying B-aminopropionitrile fumarate onto a catheter;. c) inserting the catheter into the tubular body portion for a ... 5. The method defined in claim 1 wherein the lathyrogenic agent is B-aminopropionitrile fumarate. ... 4 (October 1972). However, serious toxicity problems were encountered with systemically introduced Beta-aminopropionitrile ...
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Popis opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za...
Narodne novine d.d se obvezuju poštivati anonimnost i privatnost korisnika ovih internetskih stranica. O posjetiteljima se neće prikupljati nikakvi osobni podaci osim u slučajevima ako ih posjetitelj dobrovoljno dostavi Narodnim novinama d.d. U slučajevima kad je poznat indentitet posjetitelja/pošiljatelja, njegovi će se podaci koristiti samo u svrhu zbog koje ih je pošiljatelj poslao. Narodne novine d.d. takve podatke mogu koristiti i za što bolji uvid i razumijevanja pojedinačnih potreba i zahtjeva korisnika kao i razvijanja mogućnosti što kvalitetnijega pružanja svojih usluga korisnicima. Narodne novine d.d. se obvezuju da navedene podatke neće učiniti dostupnim bilo kojoj trećoj osobi odnosno strani bez izričitoga pristanka korisnika ...
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A new unifying hypothesis for lathyrism, konzo and tropical ataxic neuropathy: nitriles are the causative agents
Konzo and lathyrism are associated with consumption of cassava and grass pea, respectively. Cassava consumption has also been associated with a third disease, tropical ataxic neuropathy (TAN). This review presents a new unifying hypothesis on the causative agents for these diseases: namely, that the …
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Lathyrism - Wikipedia
It is caused by a different toxin (beta-aminopropionitrile), which affects the linking of collagen, a protein of connective ... It is also caused by the toxin beta-aminopropionitrile. Eating the chickling pea with grain having high concentrations of ... It is caused by the toxin beta-aminopropionitrile which inhibits the copper-containing enzyme lysyl oxidase, responsible for ... which is similar to osteolathyrism in its effects on connective tissue by means of the toxin beta-aminopropionitrile. However, ...
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Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension
Reduction of chronic hypoxic pulmonary hypertension in the rat by β-aminopropionitrile. J Appl Physiol Respir Environ Exerc ... In parallel but in separate rat cohorts, 1 day after monocrotaline injection, β-aminopropionitrile (BAPN; 100 mg/kg/d; Sigma- ... First, using a known pharmacologic inhibitor (β-aminopropionitrile, BAPN) of lysyl oxidase (Lox), the enzyme responsible for ... Reduction of blood pressure and vascular collagen in hypertensive rats by beta-aminopropionitrile. Proc Natl Acad Sci U S A. ...
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Cas 107-95-9,beta-Alanine | lookchem
At 65-70℃/(8.0-14.7kPa), decrease the pressure to recover t-butanol to obtain crude beta-aminopropionitrile. Distill the crude ... Acrylonitrile and ammonia react in a solution of diphenylamine and t-butanol to create beta-aminopropionitrile, which is then ... This method requires 982kg beta-aminopropionitrile for every ton of product, and the yield of alkalization is 90%. ... product under low pressure, collect the 66-105℃/(1.33-4.0kPa) distillation to obtain beta-aminopropionitrile, and maintain ...
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NIOSHTIC-2 Publications Search - 00211279 - In vitro and in vivo inhibition of lysyl oxidase by aminopropionitriles.
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BAPN12
- Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional groups. (wikipedia.org)
- Young mice chronically treated with β-aminopropionitrile (BAPN) were subsequently given injections of graded doses of isoproterenol, and the response of various tissues to IPR in synthesizing DNA was analyzed. (aacrjournals.org)
- To examine the role of LOX, some rats were fed food containing 0.12% β-aminopropionitrile (BAPN) (Tokyo Chemicals), a LOX inhibitor. (ahajournals.org)
- [email protected]#To establish the mouse aorta dissection (AD) model through drinking water containing β- aminopropionitrile ( BAPN ). (bvsalud.org)
- However, treatment of mice with β-aminopropionitrile (BAPN), an inhibitor of matrix cross-linking enzymes, induced subclinical POP. (jci.org)
- In parallel, RRECs were grown in HG medium and transfected with LOX small interfering RNA (siRNA), scrambled siRNA as control, or exposed to β-aminopropionitrile (BAPN), a LOX inhibitor. (arvojournals.org)
- Weanling Sprague-Dawley rats received beta-aminopropionitrile (BAPN) and/or hypertensive treatment, namely, heminephrectomy and administration of deoxycorticosterone acetate-NaCl. (researchmap.jp)
- Using 3-aminopropionitrile fumarate (BAPN)- and angiotensin II (Ang II)-induced AAD animal models, inhibition of ALDH2 was found to retard development of AAD. (onmedica.com)
- In this study, we used genipin or beta-Aminopropionitrile (BAPN) agents to induce or inhibit matrix cross-linking, respectively, to investigate the effects on outflow resistance and ECM remodeling. (elsevier.com)
- Female Sprague-Dawley rats (n=6, age 87 days) were injected twice daily for 43 days with #-aminopropionitrile (BAPN, 333 mg/kg/day i.p.), an inhibitor of lysyl oxidase, which is responsible for the production of collagen cross-links. (cdc.gov)
- Disruption of the ECM by preventing collagen deposition using the lathrytic agent β-aminopropionitrile (BAPN) inhibits LpS1 gene transcription. (elsevier.com)
- The PET experiments were carried out in the presence or absence of β-aminopropionitrile (BAPN), an irreversible inhibitor of LOX. (biomedcentral.com)
Inhibitor1
- Treatment with the LOX inhibitor β-aminopropionitrile resulted in enhanced progression of CA. Expression of procollagen type I, III, and LOX was inhibited by interleukin-1β (IL-1β) in cultured rat aortic smooth muscle cells (RASMCs) in vitro. (ahajournals.org)
Collagen3
- It is caused by a different toxin (beta-aminopropionitrile), which affects the linking of collagen, a protein of connective tissues. (wikipedia.org)
- All of the haplotype variants of LOXL1 (141R-153G, 141R-153D, 141L-153G, and 141L-153D) showed β-aminopropionitrile-inhibitable amine oxidase activity toward elastin, type I collagen, and cadaverine, indicating that each LOXL1 variant functions as an amine oxidase. (molvis.org)
- For example, Riley et al have prevented fibrosis in animal models by administering either proline analogues, which interfere with proper folding of collagen, or beta-aminopropionitrile, which interferes with collagen crosslinking. (cdc.gov)
Rats2
- We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. (utmb.edu)
- A TAI animal model was induced by orally administering ß-aminopropionitrile to rats for 6 weeks. (bvsalud.org)
Lysyl3
- It is caused by the toxin beta-aminopropionitrile which inhibits the copper-containing enzyme lysyl oxidase, responsible for cross-linking procollagen and proelastin. (wikipedia.org)
- A. Sampath Narayanan, R. C. Siegel, and G. R. Martin, "On the inhibition of lysyl oxidase by β -aminopropionitrile," Biochemical and Biophysical Research Communications , vol. 46, no. 2, pp. 745-751, 1972. (hindawi.com)
- Parmi ces gènes, je me suis intéressée à un membre de la famille des lysyl oxydases, LOXL4, qui joue un rôle clé dans la dynamique de la matrice extracellulaire en régulant la réticulation du collagène. (archives-ouvertes.fr)
Aortic1
- ß-aminopropionitrile blocked crosslinking ECM in aorta to cause structural alteration with inflammation within 1 week and then, induced aortic dissection within 4 weeks of initiating treatment, leading to mortality within 6 weeks. (bvsalud.org)
Inhibits1
- The research team identified a compound, 3-aminopropionitrile, that inhibits the enzyme that causes graft contraction and combined it with a biocompatible polymer gel invented by chemist Steve Armes, also at Sheffield. (cosmeticsandtoiletries.com)
Fumarate1
- 5. The method defined in claim 1 wherein the lathyrogenic agent is B-aminopropionitrile fumarate. (google.com)
Bone2
- Tritiated ß-aminopropionitrile was diffusely distributed throughout bone and was completely removed by saline extraction. (rupress.org)
- Importantly, treatment of GATA-1(low) mice with beta-aminopropionitrile significantly improves the bone marrow fibrotic phenotype, and MK number in the spleen. (luriechildrens.org)
Biochemical1
- Available data included measurements of tissue volume, biochemical composition, and tensile modulus for bovine calf articular cartilage (AC) explants harvested at three depths and incubated for 13 days in 20% fetal borine serum (FBS) and 20% FBS+ ß-aminopropionitrile. (calpoly.edu)
Connective tissue1
- Another type of lathyrism is angiolathyrism, which is similar to osteolathyrism in its effects on connective tissue by means of the toxin beta-aminopropionitrile. (wikipedia.org)
Toxin1
- It is also caused by the toxin beta-aminopropionitrile. (wikipedia.org)
Inhibition2
- LOX inhibition with beta-aminopropionitrile reduces PDGFR-BB binding to cells and downstream signaling, as well as its proliferative effect on the MK lineage. (luriechildrens.org)
- Then, the inhibition of the LOXL4 protein in scratch assay experiments (using β-aminopropionitrile or a specific siRNA) allowed us to demonstrate that the pro-healing effect of atRA was mediated, at least in part, by the retinoid-induction of this gene. (archives-ouvertes.fr)
Aorta1
- Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick aorta : a mongraphic study by Susan Averill Taylor. (musc.edu)
Reaction1
- Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile. (wikipedia.org)
Beta3
- Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica. (musc.edu)
- Acrylonitrile and ammonia react in a solution of diphenylamine and t-butanol to create beta-aminopropionitrile, which is then alkalized to obtain beta-aminopropionic acid. (lookchem.com)
- Differential effects of homocysteine and beta aminopropionitrile on preosteoblastic MC3T3-E1 cells. (scienceopen.com)
Beta-Aminopropionitrile3
- Some species of lathyrus, notably Lathyrus odoratus, are unable to induce human lathyrism but contain a compound, beta-aminopropionitrile (BAPN), that induces pathological changes in bone ('osteolathyrism') and blood vessels ('angiolathyrism') of experimental animals without damaging the nervous system. (elsevier.com)
- To determine the effects of LOX enzymatic activity in ccRCC, Caki-2 cells were treated with increasing concentrations of beta-aminopropionitrile (BAPN), and cell proliferation, migration, invasion and apoptosis were assessed in vitro . (ncri.org.uk)
- A paralytic condition of the legs caused by ingestion of lathyrogens, especially BETA-AMINOPROPIONITRILE or beta-N-oxalyl amino-L-alanine, which are found in the seeds of plants of the genus LATHYRUS. (wakehealth.edu)