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Theophylline
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
Herb-Drug Interactions
Cytochrome P-450 CYP3A
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Meconium Aspiration Syndrome
A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.
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Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
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Bronchodilator Agents
Adenosine
Bronchitis, Chronic
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Bundle of His
Small band of specialized CARDIAC MUSCLE fibers that originates in the ATRIOVENTRICULAR NODE and extends into the membranous part of the interventricular septum. The bundle of His, consisting of the left and the right bundle branches, conducts the electrical impulses to the HEART VENTRICLES in generation of MYOCARDIAL CONTRACTION.
Out-of-Hospital Cardiac Arrest
Heart Arrest
Sinoatrial Node
The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).
Emergency Medical Services
Ventricular Fibrillation
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Toxicity Tests
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Diarrhea
Anorexia Nervosa
An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)
Anorexia
Electronic Mail
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
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Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
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Lung Diseases, Obstructive
Inflammation
Brain blood flow and blood pressure during hypoxia in the epaulette shark Hemiscyllium ocellatum, a hypoxia-tolerant elasmobranch. (1/267)
The key to surviving hypoxia is to protect the brain from energy depletion. The epaulette shark (Hemiscyllium ocellatum) is an elasmobranch able to resist energy depletion and to survive hypoxia. Using epi-illumination microscopy in vivo to observe cerebral blood flow velocity on the brain surface, we show that cerebral blood flow in the epaulette shark is unaffected by 2 h of severe hypoxia (0.35 mg O2 l-1 in the respiratory water, 24 C). Thus, the epaulette shark differs from other hypoxia- and anoxia-tolerant species studied: there is no adenosine-mediated increase in cerebral blood flow such as that occurring in freshwater turtles and cyprinid fish. However, blood pressure showed a 50 % decrease in the epaulette shark during hypoxia, indicating that a compensatory cerebral vasodilatation occurs to maintain cerebral blood flow. We observed an increase in cerebral blood flow velocity when superfusing the normoxic brain with adenosine (making sharks the oldest vertebrate group in which this mechanism has been found). The adenosine-induced increase in cerebral blood flow velocity was reduced by the adenosine receptor antagonist aminophylline. Aminophylline had no effect upon the maintenance of cerebral blood flow during hypoxia, however, indicating that adenosine is not involved in maintaining cerebral blood flow in the epaulette shark during hypoxic hypotension. (+info)Randomised controlled trial of aminophylline for severe acute asthma. (2/267)
OBJECTIVES: To determine whether children with severe acute asthma treated with large doses of inhaled salbutamol, inhaled ipratropium, and intravenous steroids are conferred any further benefits by the addition of aminophylline given intravenously. STUDY DESIGN: Randomised, double blind, placebo controlled trial of 163 children admitted to hospital with asthma who were unresponsive to nebulised salbutamol. RESULTS: The placebo and treatment groups of children were similar at baseline. The 48 children in the aminophylline group had a greater improvement in spirometry at six hours and a higher oxygen saturation in the first 30 hours. Five subjects in the placebo group were intubated and ventilated after enrollment compared with none in the aminophylline group. CONCLUSIONS: Aminophylline continues to have a place in the management of severe acute asthma in children unresponsive to initial treatment. (+info)Pharmacokinetics of theophylline metabolites in 8 Chinese patients. (3/267)
AIM: To study theophylline metabolites pharmacokinetics in patients after a therapeutic dose. METHODS: Eight adult patients with mild bronchial asthma and normal liver function were infused aminophylline intravenously (6.6 mumol.kg-1). The plasma concentrations of theophylline and its 4 metabolites: 1,3-dimethyluric acid (DMUA), 3-methylxanthine (3-MX), 1-methyluric acid (MUA), and the intermediate 1-methylxanthine (1-MX) were monitored by HPLC throughout 24 h. RESULTS: The plasma concentration of DMUA was the highest one among the 4 metabolites. 3-MX showed the slowest elimination rate. The plasma concentration of 1-MX throughout a 24-h period showed that there was a picking up of 1-MX (from 0.04 mumol.L-1 to 1.05 mumol.L-1) in the next morning. CONCLUSION: The formation of DMUA was the main metabolites. During night there was an accumulation of 1-MX. (+info)Aminophylline alters the core temperature response to acute hypoxemia in newborn and older guinea pigs. (4/267)
In newborns and adults of a number of species, exposure to acute hypoxemia produces a "regulated" decrease in core temperature, the mechanism of which is unknown. The present experiments were carried out on chronically instrumented newborn (5-10 days of age; n = 27) and older (25-30 days of age; n = 23) guinea pigs to test the hypothesis that adenosine mediates this regulated decrease in core temperature. During an experiment, core temperature was measured by biotelemetry from animals studied in a thermocline during a control period of normoxemia, an experimental period of normoxemia or acute hypoxemia (fraction of inspired oxygen 0.10), and during a recovery period of normoxemia after an intraperitoneal injection of 10 mg/kg aminophylline (i.e., a nonspecific adenosine antagonist) or vehicle. Core temperature decreased significantly during hypoxemia after vehicle in both newborn and older guinea pigs. After aminophylline, however, newborn guinea pigs failed to significantly decrease their core temperature, whereas older guinea pigs exhibited an attenuated yet significant core temperature decrease during hypoxemia. Our data support the hypothesis that adenosine plays an age-dependent role in mediating the regulated decrease in core temperature that occurs in newborn and older guinea pigs during acute hypoxemia. (+info)Adenosine contributes to hypoxia-induced forearm vasodilation in humans. (5/267)
In humans, hypoxia leads to increased sympathetic neural outflow to skeletal muscle. However, blood flow increases in the forearm. The mechanism of hypoxia-induced vasodilation is unknown. To test whether hypoxia-induced vasodilation is cholinergically mediated or is due to local release of adenosine, normal subjects were studied before and during acute hypoxia (inspired O(2) 10.5%; approximately 20 min). In experiment I, aminophylline (50-200 microg. min(-1). 100 ml forearm tissue(-1)) was infused into the brachial artery to block adenosine receptors (n = 9). In experiment II, cholinergic vasodilation was blocked by atropine (0.4 mg over 4 min) infused into the brachial artery (n = 8). The responses of forearm blood flow (plethysmography) and forearm vascular resistance to hypoxia in the infused and opposite (control) forearms were compared. During hypoxia (arterial O(2) saturation 77 +/- 2%), minute ventilation and heart rate increased while arterial pressure remained unchanged; forearm blood flow rose by 35 +/- 6% in the control forearm but only by 5 +/- 8% in the aminophylline-treated forearm (P < 0.02). Accordingly, forearm vascular resistance decreased by 29 +/- 5% in the control forearm but only by 9 +/- 6% in the aminophylline-treated forearm (P < 0.02). Atropine did not attenuate forearm vasodilation during hypoxia. These data suggest that adenosine contributes to hypoxia-induced vasodilation, whereas cholinergic vasodilation does not play a role. (+info)Mutability of different genetic loci in mammalian cells by metabolically activated carcinogenic polycyclic hydrocarbons. (6/267)
The relationship between carcinogenesis and mutagenesis in mammalian cells has been determined with 10 polycyclic hydrocarbons with different degrees of carcinogenicity. Mutagenesis was determined in Chinese hamster cells with genetic markers that affect the surface membrane, nucleic-acid synthesis, and protein synthesis. The mutations were characterized by resistance to ouabain, 8-azaguanine, and temperature. Mutagenesis by the carcinogens required metabolic activation and this was provided by the presence of lethally irradiated metabolizing cells. The degree of carcinogenicity was related to the degree of mutagenicity for all three genetic markers. The most potent carcinogen, 7,12-dimethylbenz[a]anthracene, gave the highest mutagenicity and mutagenicity was obtained with 0.01 mug/ml. Treatment of the cells with aminophylline, which increases polycyclic hydrocarbon metabolism, increased mutagenesis by the carcinogens. It is suggested that such an experimental system with these and other mammalian cells should be useful as a sensitive assay for hazardous environmental chemicals. (+info)Pharmacological properties of some xanthone derivatives. (7/267)
A series of aminoalkanolic derivatives of xanthone were examined in some experimental models of epilepsia, i.e., pilocarpine, aminophylline and pentetrazole-induced seizures. A final objective of this research was to examine the action of these compounds on the central nervous system, namely on spontaneous locomotor activity, amphetamine-induced hyperactivity and narcotic sleep induced by hexobarbital, as well as their influence on the gamma-aminobutyric acid (GABA) level and glutamic acid decarboxylase (GAD) activity in mice brain. The most interesting were the pharmacological results of (R)-2-N-methylamino-1-butanol derivative of 7-chloro-2-methylxanthone [Id], which displayed protective activity against the seizures induced by maximum electroshock and pentetrazole induced seizures; moreover, this compound had a relatively low toxicity and did not exhibit a neurotoxic effect. The influence on the locomotor activity as well as on the amphetamine-induced locomotor hyperactivity in mice was also seen for Id. Compound Id did not decrease the GABA level in mice brain. (+info)Metabolic and respiratory effects of theophylline in the preterm infant. (8/267)
BACKGROUND: Methylxanthines are often administered to preterm infants for the treatment of apnoea. AIMS: To study the effects of theophylline on energy metabolism, physical activity, and lung mechanics in preterm infants. METHODS: Indirect calorimetry was performed for six hours before and after administration of a bolus of theophylline (5 mg/kg) in 18 preterm infants while physical activity was recorded with a video camera. Lung mechanics measurements were performed at baseline and 12 and 24 hours after theophylline treatment. RESULTS: Theophylline increased mean (SEM) energy expenditure by 15 (5) kJ/kg/day and augmented carbohydrate utilisation from 6.8 to 8.0 g/kg/day, but fat oxidation was unchanged. After theophylline treatment, preterm infants had faster respiration, lower transcutaneous CO2, and improved static respiratory compliance without increased physical activity. CONCLUSIONS: A bolus of 5 mg/kg theophylline increased energy expenditure independently of physical activity, increased carbohydrate utilisation, and improved respiratory compliance. The increased energy expenditure could be detrimental to the growth of the preterm infant. (+info)
Effect of aminophylline on brain stem auditory evoked potentials in preterm infants<...
Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators | Cochrane
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February 1993). "Aminophylline for bradyasystolic cardiac arrest refractory to atropine and epinephrine". Annals of Internal ... Burton JH, Mass M, Menegazzi JJ, Yealy DM (August 1997). "Aminophylline as an adjunct to standard advanced cardiac life support ... Khoury MY, Moukarbel GV, Obeid MY, Alam SE (May 2001). "Effect of aminophylline on complete atrioventricular block with ... Mader TJ, Smithline HA, Durkin L, Scriver G (March 2003). "A randomized controlled trial of intravenous aminophylline for ...
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Aminophylline may also work, while estrogen can be effective in women. There is at present no known cure however a change in ... Can make coronary spasms worse aminophylline - may work by inhibiting adenosine receptors. estrogen - may work in women. L- ...
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Morphine, cosyntropin, and aminophylline appear effective in reducing post dural puncture headaches. Evidence does not support ...
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Aminophylline can be used to reverse the effects of dipyridamole and regadenoson). Scanning may then be performed with a ...
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According to a new randomized control trial ketamine and aminophylline are also effective in children with acute asthma who ... Jat, KanaRam; Tiwari, Abhimanyu; Guglani, Vishal (2016). "Ketamine versus aminophylline for acute asthma in children: A ...
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In adult rats, the LD50 of caffeine and aminophylline was the same after 24 h and after 1 week of observation: caffeine 265 mg/ ... "Comparative toxicity of caffeine and aminophylline (theophylline ethylenediamine) in young and adult rats". Biology of the ...
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Aminophylline treatment is associated with more adverse effects compared to inhaled beta-2 agonist treatment. Mast cell ... Nair P, Milan SJ, Rowe BH (December 2012). "Addition of intravenous aminophylline to inhaled beta(2)-agonists in adults with ... Intravenous administration of the drug aminophylline does not provide an improvement in bronchodilation when compared to ...
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Adenosine antagonists such as the methylxanthines theophylline and aminophylline, may help although studies have conflicting ...
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... aminophylline, succinylcholine, reserpine, and phenothiazine-type tranquilizers should be avoided in patients with ...
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Administration of theophylline or aminophylline has been shown to reduce the sedative effects of temazepam and other ...
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Aminophylline may be used to attenuate severe and/or persistent adverse reactions to Adenosine and Lexiscan. The stress test ...
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Other medications that rarely increase the risk of developing atrial fibrillation include adenosine, aminophylline, ...
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Burton JH, Mass M, Menegazzi JJ, Yealy DM (1997). "Aminophylline as an adjunct to standard advanced cardiac life support in ... Mader TJ, Bertolet B, Ornato JP, Gutterman JM (2000). "Aminophylline in the treatment of atropine-resistant bradyasystole". ... Mader TJ, Smithline HA, Durkin L, Scriver G (2003). "A randomized controlled trial of intravenous aminophylline for atropine- ... Khoury MY, Moukarbel GV, Obeid MY, Alam SE (2001). "Effect of aminophylline on complete atrioventricular block with ventricular ...
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Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
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A Moderate Drug Interaction exists between aminophylline and Ventolin. View detailed information regarding this drug ... Using aminophylline together with albuterol may increase cardiovascular side effects such as heart palpitations, increased ... these medications given orally or by injection may sometimes reduce the blood levels and effects of aminophylline. You may need ...
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Aminophylline in the hospital treatment of children with acute asthma BMJ 1994; 308 :1384 ... In 1971 Pierson and colleagues showed that in children with acute asthma, intravenous aminophylline provided additional benefit ... Aminophylline in the hospital treatment of children with acute asthma. BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6941. ...
Aminophylline in Bradyasystolic Cardiac Arrest - Full Text View - ClinicalTrials.gov
Aminophylline is a competitive antagonist of adenosine. The use of aminophylline for bradycardia and heart block has been ... Aminophylline in Bradyasystolic Cardiac Arrest. The safety and scientific validity of this study is the responsibility of the ... Drug: Aminophylline (250mg IV +/- a second dose of 250mg IV) Phase 2 ... Aminophylline. Bronchodilator Agents. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Anti- ...
Aminophylline overdose | Health Encyclopedia | FloridaHealthFinder.gov
Aminophylline and theophylline can be poisonous in large doses.. Where Found. Aminophylline and theophylline are found in ... Aminophylline overdose. Definition. Aminophylline and theophylline are medicines used to treat lung diseases such as asthma. ... Aminophylline or theophylline overdose occurs when someone takes more than the normal or recommended amount of these medicines ... Other products may also contain aminophylline and theophylline.. Symptoms. The most serious life-threatening symptoms of ...
Aminophylline for the Prevention of Apnea During Prostaglandin E1 Infusion | ELECTRONIC ARTICLES | Pediatrics
In the aminophylline group, serum levels were 7.6 ± 1.2 μg/mL. No significant side effects of aminophylline were seen. Infants ... Open circles represent apneic events without intubation in the aminophylline group. No infants in the aminophylline group ... Aminophylline for the Prevention of Apnea During Prostaglandin E1 Infusion. D.S. Lim, Thomas J. Kulik, Dennis W. Kim, John R. ... the use of aminophylline in neonates with ductal-dependent congenital heart disease has not been described. Aminophylline was ...
Interaction between isoprenaline and aminophylline in asthma | Thorax
... aminophylline intravenously (10), isoprenaline and aminophylline (11), or placebo (8). The maximum expiratory flow (V max), the ... The combination of isoprenaline and aminophylline acted synergistically in terms of the percent increase in V max50. However, ... Interaction between isoprenaline and aminophylline in asthma. Using a factorially designed study, 38 patients with bronchial ... smooth muscle tone are mediated by concentrations of cyclic nucleotides and that combinations of isoprenaline and aminophylline ...
Aminophylline Toxicity: Specialist
Another name for Aminophylline Toxicity is Theophylline Toxicity. Physicians from the following specialties evaluate and treat ... Continue to Aminophylline Toxicity Home Care Last Updated: Jul 10, 2009 References Authors: Stephen J. Schueler, MD; John H. ... Aminophylline Toxicity Specialist. Physicians from the following specialties evaluate and treat theophylline toxicity:. * ... PubMed Aminophylline Toxicity References *Henderson JH, McKenzie CA, Hilton PJ, Leach RM. Continuous venovenous haemofiltration ...
Aminophylline Toxicity: Symptoms
Another name for Aminophylline Toxicity is Theophylline Toxicity. Symptoms of theophylline toxicity include: * Abdominal pain ... Continue to Aminophylline Toxicity Treatment Last Updated: May 6, 2010 References Authors: Stephen J. Schueler, MD; John H. ... PubMed Aminophylline Toxicity References *Henderson JH, McKenzie CA, Hilton PJ, Leach RM. Continuous venovenous haemofiltration ...
Aminophylline 100 mg, 100 Tablets | VetDepot.com
VetDepot offers Aminophylline 100 mg, 100 Tablets at the most competitive prices. Get the best deals on all your pet meds at ... Aminophylline pet meds are primarily bronchodilators, but they can also be used to treat heart failure in certain cases.*Treats ... Aminophylline 100 mg, 100 Tablets is a medication that treats bronchospasms to open the airways in dogs and cats suffering from ... ", "prodUrl":"/aminophylline-100-mg-500-tablets.html", "vars": [ {"varInfo":["tablets","500"]} , {"varInfo":["mg","100 ...
Points: Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline |...
Points: Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline Br ... Points: Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline. Br ... Points: Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline ... Points: Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline ...
Aminophylline - Proxim
Aminophylline for Pets - Bronchodilator Pet Medications | VetDepot.com
Get the best prices on Aminophylline cat asthma and dog asthma pet medications today from Vet Depot. No Aminophylline coupons ... Buy discount Aminophylline for pets at the cheapest prices. ... Do not use Aminophylline in animals with a known allergy to it ... Benefits of Aminophylline:. *Opens the airways to improve breathing. *Effective treatment for COPD, pulmonary edema, and other ... Store Aminophylline in a tightly closed container, at room temperature, and away from moisture, light, and heat. Do not keep ...
1800PetMeds: Aminophylline is used to treat pets who have suffered heart failure - 1800PetMeds
Pulsed proton NMR and solid-liquid fat ratio determinations in suppository vehicles and aminophylline suppositories |...
... melting behaviour and release rate of aminophylline suppositories were studied during storage. The fraction of non-crystallized ... Biopharmaceutics of aminophylline suppositories. II.In vitro release rate during storage. Pharm Acta Helv 1977;52:11-4.PubMed ... Decomposition of aminophylline in suppository formulations. J Pharm Sci 1980;69:942-5.PubMedGoogle Scholar ... Biopharmaceutics of aminophylline suppositories I. Introduction andin vitro melting behaviour. Pharm Acta Helv 1976;51:186-92. ...
Study of BCG + Aminophylline Toxicity When Used in the Treatment of Bladder Cancer - Tabular View - ClinicalTrials.gov
Aminophylline has not been given to anyone who has bladder cancer. Aminophylline is approved by the U.S. Food and Drug ... Drug: aminophylline One of three escalating doses of aminophylline (3 mg/kg, 6 mg/kg and 9 mg/kg) administered intravesically ... This is a study about aminophylline instilled into the bladder. Aminophylline has not been proven to be safe or a helpful ... Experimental: BCG + aminophylline Bacillus Calmette-Guerin (BCG) plus one of three escalating doses of aminophylline ...
Effects of aminophyllineAsthmaBronchodilatorDosageDose of aminophyllineDoses of aminophyllineEffect of aminophyllineSuggest that aminophyllineDrugsXanthineEither aminophylline or placeboPlacebo25mg100mgBronchialToxicityComplex of theophylline and ethylenediamineBronchodilatorsTabletEthylenediamine in 2:1 ratioSide effectsTherapeuticCardiacInteractionsSignificantlyGreater water solubilityIntravenouslyAdenosine receptorLungTabletsPatients with acuteTake aminophyllineNonselective phosphodiesterase inhibitorPharmaceuticalDihydrate10mLAdverseOverdoseAnhydrousInfusionInjection USPTreatmentRespiratoryArrhythmiasCOPDEvaluateRelaxesDrugOralPharmacologicalInducesAcutely
Effects of aminophylline9
- they can increase the side effects of aminophylline. (medlineplus.gov)
- However, elderly patients may be more sensitive to the effects of aminophylline than younger adults, which may require caution and an adjustment in the dose for patients receiving aminophylline. (mayoclinic.org)
- In addition, these medications given orally or by injection may sometimes reduce the blood levels and effects of aminophylline. (drugs.com)
- Sarilumab may decrease the blood levels and effects of aminophylline. (drugs.com)
- No significant side effects of aminophylline were seen. (aappublications.org)
- To evaluate the effects of aminophylline (Am) in children hospitalized with asthma. (aappublications.org)
- To reduce the undesirable stimulating effects of aminophylline on the central nervous and cardiovascular systems, intravenous administration of the drug should be slow and should not exceed a rate of 25 mg/min. (medicines.org.uk)
- In biological fluids aminophylline dissociates to theophylline hence the pharmacological effects of aminophylline are those of theophylline. (sgpharma.com)
- To determine the neurophysiological effects of aminophylline on apnoea of prematurity, the brain stem auditory evoked potentials (BAEPs) of 30 apnoeic infants and 34 age matched controls were evaluated and compared. (elsevier.com)
Asthma39
- Aminophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases. (medlineplus.gov)
- Aminophylline controls symptoms of asthma and other lung diseases but does not cure them. (medlineplus.gov)
- Aminophylline and theophylline are medicines used to treat lung diseases such as asthma. (medlineplus.gov)
- Aminophylline is used together with other medicine to treat the symptoms of asthma, bronchitis, emphysema, and other lung diseases. (mayoclinic.org)
- Intravenous aminophylline can be used for acute exacerbation of symptoms and reversible airway obstruction in asthma and other chronic lung disease such as COPD, emphysema and chronic bronchitis. (wikipedia.org)
- Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. (drugbank.ca)
- In 1971 Pierson and colleagues showed that in children with acute asthma, intravenous aminophylline provided additional benefit when added to a regimen of hydrocortisone and sympathomimetic drugs. (bmj.com)
- Using a factorially designed study, 38 patients with bronchial asthma received a single dose of either isoprenaline by inhalation (9), aminophylline intravenously (10), isoprenaline and aminophylline (11), or placebo (8). (bmj.com)
- These observations support the concept that changes in bronchial smooth muscle tone are mediated by concentrations of cyclic nucleotides and that combinations of isoprenaline and aminophylline, rather than the administration of each drug separately, may have therapeutic advantages in the treatment of bronchial asthma. (bmj.com)
- Aminophylline 100 mg, 100 Tablets is a medication that treats bronchospasms to open the airways in dogs and cats suffering from asthma or having other difficulties breathing. (vetdepot.com)
- Aminophylline is a prescription pet medication that is used to treat dog and cat asthma, chronic bronchitis, and other breathing problems. (vetdepot.com)
- Aminophylline is a bronchodilator medication that treats bronchospasms to open the airways in animals that are having trouble breathing due to asthma or another cause. (vetdepot.com)
- Aminophylline works by relaxing the smooth muscles in your pet's airways that contract and impede airflow during an asthma attack or other respiratory event. (vetdepot.com)
- Aminophylline is approved by the U.S. Food and Drug Administration (FDA ) to give directly into the bloodstream for the treatment of asthma. (clinicaltrials.gov)
- We suggest that aminophylline treatment has adverse effects in patients with hypoxaemia subsequent to respiratory disorders such as asthma. (wiley.com)
- The voluminous reports bearing upon the pathogenesis of cardiac asthma, its relationship to bronchial asthma and the value of aminophylline in therapy present basic disagreements regarding both the statistical evaluation and the theoretic concepts. (annals.org)
- Does Aminophylline Benefit Adults Admitted to the Hospital for an Acute Exacerbation of Asthma? (annals.org)
- In the past, aminophylline has been extensively used for the management of acute asthma, despite side effects. (cochrane.org)
- Aminophylline use in children may be appropriate if children have a role in severe acute exacerbations of asthma where response to maximised therapy (inhaled bronchodilators and glucocorticoids) is poor. (cochrane.org)
- In children with a severe asthma exacerbation, the addition of intravenous aminophylline to ß 2 -agonists and glucocorticoids (with or without anticholinergics) improves lung function within 6 hours of treatment. (cochrane.org)
- Since the advent of inhaled ß 2 -agonists, anticholinergic agents and glucocorticoids, the role of aminophylline in paediatric acute asthma has become less clear. (cochrane.org)
- Aminophylline Injection is indicated for relief of bronchospasm associated with asthma and in chronic obstructive pulmonary disease. (medicines.org.uk)
- Does aminophylline cure asthma? (healthtap.com)
- Is a cellulite lotion which contains the asthma drug, aminophylline safe to use? (healthtap.com)
- Aminophylline has been a useful drug for asthma . (healthtap.com)
- Aminophylline treats asthma and COPD. (rxwiki.com)
- Theophylline, its salts, and its derivatives (examples are aminophylline, oxtriphylline) are bronchodilators which relaxe and open the air passages to the lungs to increase the flow of air through them, and thus are used in the treatment and/or prevention of symptoms of bronchial asthma and of reversible bronchospasm associated with chronic bronchitis and emphysema. (chemicalland21.com)
- To evaluate intravenous aminophylline as an adjunct to treatment with metaproterenol sulfate and methylprednisolone for patients with asthma exacerbation or wheezing. (acpjc.org)
- In recent years, clinical investigators have re-evaluated the role of intravenous aminophylline in the emergency room treatment of asthma. (acpjc.org)
- The National Heart, Lung, and Blood Institute's (NHLBI) recently published National Asthma Education Program Expert Panel Report ( 1 ) stated: "When used in combination with repetitively administered β 2 -agonist bronchodilators, intravenous aminophylline causes increased adverse side effects without affecting additive bronchodilation. (acpjc.org)
- The observation that intravenous aminophylline may reduce hospital admissions for patients with an acute exacerbation of asthma or COPD is worthy of debate and further investigation. (acpjc.org)
- IV beta(2)-agonist agents and IV aminophylline may also be considered as additional interventions in this setting and this review compares IV beta-agonist agents and IV aminophylline in the treatment of people with acute asthma. (altmetric.com)
- Your physician should prescribe a fast-acting relief medication or inhaler for sudden asthma or shortness of breath attacks while you're on Aminophylline. (healthery.com)
- AMINOPHYLLINE INJECTION USP (Aminophylline) is used as a bronchodilator in the management of asthma and chronic obstructive pulmonary disease. (sgpharma.com)
- AMINOPHYLLINE INJECTION USP is indicated for the treatment of reversible bronchospasm associated with chronic bronchitis, emphysema, bronchial asthma and chronic obstructive pulmonary disease. (sgpharma.com)
- Bronchodilator, Asthma, Respiratory System manufacturer / supplier in China, offering Western Medicine Aminophylline Tablet B. P. 100mg, GMP Certified Idomethacin 100mg Suppository, GMP Certified Paracetamol 500mg/3ml Injection and so on. (made-in-china.com)
- Aminophylline is an effective drug for the treatment of bronchial asthma, recent experimental studies have shown that in addition to a role of bronchial relaxation, aminophylline, immune and anti-inflammatory role. (dissertationtopic.net)
- With effective drug for the treatment of bronchial asthma, for the aminophylline whether intervention in the epithelial cells, thereby affecting the ability of phagocytosis of apoptotic eosinophils unclear. (dissertationtopic.net)
- Therefore study the role of the eosinophils intervention aminophylline phagocytosis of apoptotic epithelial cells and IL-6 , IL-8 secretion, research aminophylline role in the treatment of bronchial asthma and anti-inflammatory the role of the new ideas of great significance, and provide a new basis for bronchial asthma clinical treatment. (dissertationtopic.net)
Bronchodilator7
- Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. (wikipedia.org)
- Aminophylline functions as a bronchodilator and opens air passages in the lungs. (vetdepot.com)
- Aminophylline directly relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels, thus acting mainly as a bronchodilator, pulmonary vasodilator and smooth muscle relaxant. (bushorchimp.com)
- Aminophylline may be preferred to enhance contractility in the diaphragm/lungs or benefit from it's bronchodilator properties. (healthtap.com)
- Aminophylline 250 MG Injection is a very effective bronchodilator medicine. (salvavidaspharmaceutical.com)
- Aminophylline is considered a xanthine bronchodilator type of medication. (pharmacygeoff.md)
- Aminophylline is a bronchodilator, Aminophylline relaxes bronchial smooth muscle, relieves bronchospasm, and has a stimulant effect on respiration. (made-in-china.com)
Dosage6
- One of the dosage forms available for Aminophylline is Oral Suspension. (wedgewoodpharmacy.com)
- Aminophylline is also available in these dosage forms. (wedgewoodpharmacy.com)
- Aminophylline dosage will depend on your age, weight, response to treatment, drug blood levels, medical condition, and other medicines you may be using. (healthery.com)
- In the elderly, the half-life of Aminophylline may be prolonged (A reduction of dosage may be necessary). (drugspi.org)
- The effective therapeutic dosage of aminophylline is not much different from the toxic dosage, and its toxicity can be caused by excessive dosage of oral administration, rectal administration and intramuscular injection, too short medication interval, too large dosage or too fast intravenous injection, and a few are caused by too high sensitivity to this drug. (medicinephone.com)
- In the case of use in combination with enoxacin and other fluoroquinolin, small doses of ethanol, disulfiram, recombinant interferon alpha, methotrexate, propafenone, thiabendazole, ticlopidine, verapamil and vaccination against influenza intensity aminophylline steps may increase, which may involve reducing its dosage. (pharmru.com)
Dose of aminophylline3
- Likewise, if you have been receiving both medications, the dose of aminophylline may need to be adjusted when sarilumab is discontinued. (drugs.com)
- We also would like to determine the maximum dose of aminophylline that can be safely given and how the drug is absorbed and used by the body as well as document side effects when aminophylline is given in the bladder. (clinicaltrials.gov)
- The highest dose of aminophylline suppressed the killing of S. aureus so that 55 ± 5% of the initial viable bacteria remained as compared with 22 ± 4% in the control animals. (elsevier.com)
Doses of aminophylline3
- Bacillus Calmette-Guerin (BCG) plus one of three escalating doses of aminophylline administered intravesically. (clinicaltrials.gov)
- When therapeutic doses of Aminophylline and/or theophylline are administered simultaneously by more than one route or in more than one preparation, the hazard of serious toxicity is increased. (medicines.org.uk)
- From the lungs of untreated animals 5.0 ± 0.3 x 10 6 PMN were recovered as compared with 3.3 ± 0.1 x 10 6 , 2.5 ± 0.2 x 10 6 , and 1.8 ± 0.1 x 10 6 , respectively, with increasing doses of aminophylline. (elsevier.com)
Effect of aminophylline5
- Certain diets (such as high protein /low carbohydrate or high carbohydrate/low protein) may change the effect of aminophylline . (webmd.com)
- The purpose of this study is to evaluate the effect of aminophylline in patients with out-of-hospital bradyasystolic cardiac arrest. (clinicaltrials.gov)
- We undertook this study to evaluate the effect of aminophylline during cardiopulmonary resuscitation (CPR) of patients with out-of-hospital bradyasystolic cardiac arrest unresponsive to initial therapy. (clinicaltrials.gov)
- In logistic regression, the adjusted odds ratio for the effect of aminophylline on admission rate was 0.22 (CI 0.12 to 0.42). (acpjc.org)
- Appointment of beta-blockers prevent the bronchodilatory effect of aminophylline and may cause bronchospasm. (pharmru.com)
Suggest that aminophylline2
- We have data in mice that suggest that aminophylline slows the growth of tumors when coupled with BCG. (clinicaltrials.gov)
- These results suggest that aminophylline may enhance conduction along central auditory pathways and stimulate the regulatory effect on the respiratory centre of the brain stem. (elsevier.com)
Drugs5
- tell your doctor and pharmacist if you are allergic to aminophylline or any other drugs. (medlineplus.gov)
- Aminophylline belongs to a class of drugs known as xanthines. (webmd.com)
- Aminophylline should not be administered concomitantly with other xanthine drugs. (medicines.org.uk)
- Multiple population: excessive or mistaken aminophylline drugs or coffee. (medicinephone.com)
- Oral estrogen-containing contraceptives, antidiarrheal drugs, intestinal sorbents weaken and H2-histamine blockers, calcium channel blockers slow, mexiletine enhance the effect (associated with the cytochrome P450 enzyme system and alter the metabolism of aminophylline). (pharmru.com)
Xanthine3
- Like other methylated xanthine derivatives, aminophylline is both a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene synthesis, and reduces inflammation and innate immunity and nonselective adenosine receptor antagonist. (wikipedia.org)
- Aminophylline is classified as a xanthine. (healthery.com)
- Caffeine and aminophylline are both derivatives of xanthine, and their pharmacological effects are similar, but only different in action intensity. (medicinephone.com)
Either aminophylline or placebo3
- In a prospective, double-blinded, placebo-controlled study, newborn infants with ductal-dependent congenital heart disease were randomized to receive either aminophylline or placebo during initiation and maintenance of PGE 1 , which was started at 0.01 μg/kg/min and increased to 0.03 μg/kg/min. (aappublications.org)
- Infants were prospectively randomized in a double-blinded fashion to receive either aminophylline or placebo, and this study drug was administered either before or during initiation of PGE 1 therapy. (aappublications.org)
- Rib cage (RC-Ap) and abdominal (AB-Ap) volume displacements, pleural (Ppl), gastric (Pg), and transdiaphragmatic (Pdi) pressure swings, and electromyographic activity of the diaphragm (Edi) and the parasternal (Eps) muscles were measured under control and during infusion of either aminophylline or placebo in a double-blind randomized manner. (elsevier.com)
Placebo10
- This review found evidence that children treated with aminophylline had a greater improvement in lung function than children treated with placebo , when both groups received inhaled bronchodilators and steroids and they responded incompletely to these initial therapies. (cochrane.org)
- The addition of aminophylline to steroids and ß 2 -agonist significantly improved FEV 1 % predicted over placebo at 6-8 hours, 12-18 hours and 24 hours. (cochrane.org)
- Aminophylline led to a greater improvement in PEF% predicted over placebo at 12-18 hours. (cochrane.org)
- 2 patients, 1 receiving placebo and 1 receiving aminophylline, were removed from the study because of respiratory failure requiring mechanical ventilation. (annals.org)
- Aminophylline infusion rates were adjusted by an unblinded investigator to achieve theophylline levels of 72 to 83 µmol/L. Changes were also made in placebo infusion rates to maintain the double-blind design. (annals.org)
- 0.2), or time in the emergency department (median, 205 min vs 220 min, P = 0.11) between the aminophylline and placebo groups, respectively. (acpjc.org)
- The most common reason for admission was failure to clear after 6 h (100% of aminophylline admissions and 77% of placebo-group admissions). (acpjc.org)
- We can only speculate why more patients in the placebo-treated group were admitted when their pulmonary function tests were not worse than those of the aminophylline-treated group. (acpjc.org)
- Methods: In this study we administered (1 mg/kg) of aminophylline in group A, (0.15 mg/kg) of ondansetron in group B and 5 cc of normal saline as placebo in control group. (alliedacademies.org)
- Aminophylline infusion rates were adjusted by an unblinded investigator to achieve theophylline levels of 72 to 83 μmol/L. Changes were also made in placebo infusion rates to maintain the double-blind design. (umn.edu)
25mg1
- a) A loading dose of 6mg/kg body weight of aminophylline may be given by slow intravenous injection at a rate not exceeding 25mg/min. (medicines.org.uk)
100mg2
- Aminophylline Tablets BP 100mg: white round tablet plain on both sides. (made-in-china.com)
- Aminophylline BP 100mg. (made-in-china.com)
Bronchial2
- After ingestion, theophylline is released from aminophylline, and theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. (drugbank.ca)
- Aminophylline is a complex of theophylline and ethylenediamine and is given for its theophylline activity to relax smooth muscle and to relieve bronchial spasm. (medicines.org.uk)
Toxicity2
- Aminophylline can lead to theophylline toxicity. (wikipedia.org)
- Interactions with ciprofloxacin and erythromycin leading to aminophylline toxicity. (oup.com)
Complex of theophylline and ethylenediamine1
- Aminophylline is a 2:1 complex of theophylline and ethylenediamine. (nih.gov)
Bronchodilators2
- Aminophylline belongs to a group of medicines known as bronchodilators. (mayoclinic.org)
- Aminophylline pet meds are primarily bronchodilators, but they can also be used to treat heart failure in certain cases. (vetdepot.com)
Tablet3
- Aminophylline comes as a tablet and syrup to take by mouth and a suppository to insert rectally. (medlineplus.gov)
- What conditions does Aminophylline Tablet treat? (webmd.com)
- List Aminophylline Tablet side effects by likelihood and severity. (webmd.com)
Ethylenediamine in 2:1 ratio1
- Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio. (bionity.com)
Side effects8
- Aminophylline may cause side effects. (medlineplus.gov)
- However, children younger than 1 year of age are more likely to have serious side effects, which may require caution and an adjustment in the dose for patients receiving aminophylline. (mayoclinic.org)
- Using aminophylline together with albuterol may increase cardiovascular side effects such as heart palpitations, increased heart and pulse rates, and blood pressure elevations. (drugs.com)
- So how often do I have to take albuterol, prednisolone and aminophylline in order to reduce its side effects on the body. (healthtap.com)
- We aimed to evaluate the use and side-effects of IV aminophylline in AECOPD presenting with acidotic T2RF who also received NIV. (ersjournals.com)
- Of course, not all these Aminophylline side effects can occur but if they happen, you may require medical attention. (healthery.com)
- Some Aminophylline side effects can happen that usually need no medical attention. (healthery.com)
- Although aminophylline has several physiological effects on the heart tissue, it has been recognized to have some side effects. (org.ir)
Therapeutic2
- Aminophylline has a narrow therapeutic index and serum levels should be monitored regularly, particularly during initiation of therapy. (medicines.org.uk)
- Theophylline, (and hence aminophylline), has a low therapeutic index. (sgpharma.com)
Cardiac7
- Aminophylline causes bronchodilation, diuresis†, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells. (wikipedia.org)
- Aminophylline competitively antagonizes the cardiac actions of adenosine at the cell surface receptors. (wikipedia.org)
- Soar J (2007), "Aminophylline in bradyasystolic cardiac arrest", Emerg. (wikipedia.org)
- The use of aminophylline for bradycardia and heart block has been described, and a number of anecdotal reports and small studies have been published on the use of aminophylline in cardiac arrest. (clinicaltrials.gov)
- This increase in flow could have been brought about only by redistribution of the cardiac output through differential effects on different vascular beds, since unlike papaverine and aminophylline, cetiedil does not increase cardiac output. (aspetjournals.org)
- Aminophylline should be given with caution to patients with peptic ulceration, hyperthyroidism, hypertension, cardiac arrhythmias or other cardiovascular disease, or epilepsy. (made-in-china.com)
- The results of the current study indicated that a slow infusion rate could prevent the cardiac complications of aminophylline, particularly arrhythmias, in neonate rats. (org.ir)
Interactions1
- Interactions are always an issue for a therapist, take for second example aminophylline interacting with darunavir. (top-web.us)
Significantly7
- Key findings Under hypoxic conditions, aminophylline significantly increased the concentration of brain-specific creatine kinase in the serum in a dose- and time-dependent manner. (wiley.com)
- The bactericidal activity of lavaged PMN from the lungs of aminophylline-treated rats challenged with the gram-negative bacterium in vivo was significantly depressed when compared with that in control animals. (elsevier.com)
- Conclusion: This study shows that although (0.15 mg/kg) ondansetron does not reduce the incidence of PDPH, it significantly reduces the severity of headache also shows that aminophylline has no effect on reduction of incidence nor severity of PDPH. (alliedacademies.org)
- Edi and Eps increased significantly with aminophylline, whereas Pdi/Edi ratio remained unchanged. (elsevier.com)
- Additionally, the PR interval and QTc significantly increased in the rats receiving aminophylline for 3 minutes. (org.ir)
- A549 cells phagocytic capacity aminophylline 10-3 mol / L the phagocytic capacity minimum concentration intervention, 10-4 mol / L ,10-5 mol / L significantly increased. (dissertationtopic.net)
- The mean latencies of the peaks and interpeaks of all waves except wave I were significantly lower in the apnoeic infants after than before receiving aminophylline. (elsevier.com)
Greater water solubility2
- Aminophylline is a complex of theophylline-ethylenediamine, it has greater water solubility than Theophylline . (drugspi.org)
- Aminophylline has greater water solubility than theophylline. (sgpharma.com)
Intravenously2
- 65 patients also received aminophylline intravenously, 5.6 mg/kg body weight over 20 min, followed by a constant infusion of 0.9 mg/kg per hour. (acpjc.org)
- Thirty-two male Sprague-Dawley rats (10 days old, 50 g) were divided into 4 groups (8 in each): Group I and Group II were treated with 5 mg/kg of normal saline intravenously for 3 and 20 minutes, correspondingly, and Group III and Group IV were treated with a 5-mg/kg bolus of aminophylline intravenously for 3 and 20 minutes, respectively. (org.ir)
Adenosine receptor2
- Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor. (wikipedia.org)
- Older research on adenosine receptor function, and non-selective adenosine receptor antagonists such as aminophylline, focused mainly on the role of adenosine receptors in the heart, and led to several randomized controlled trials using these receptor antagonists to treat bradyasystolic arrest. (wikipedia.org)
Lung1
- A new study indicates that aminophylline plays an essential role in mitochondrial biogenesis in epithelial cells of the lung. (statpearls.com)
Tablets3
- Aminophylline comes in the form of an oral solution, oral tablets, and extended-release- tablets. (statpearls.com)
- Don't chew or crush Aminophylline tablets. (healthery.com)
- Amnivent SR prolonged release tablets contain the active ingredient aminophylline. (netdoctor.co.uk)
Patients with acute2
- The use of Aminophylline is contra-indicated in patients with acute porphyria. (medicines.org.uk)
- Adjunctive intravenous aminophylline for patients with acute bronchospastic disease may reduce hospital admissions from the emergency department. (acpjc.org)
Take aminophylline4
- Take aminophylline exactly as directed. (medlineplus.gov)
- Continue to take aminophylline even if you feel well. (medlineplus.gov)
- Take aminophylline exactly as prescribed by your doctor. (rxwiki.com)
- Take Aminophylline orally with or without meals, usually two to four times a day or as ordered by your healthcare giver. (healthery.com)
Nonselective phosphodiesterase inhibitor1
- Most term and preterm infants admitted to the neonatal intensive care unit (NICU) suffer from respiratory diseases, and generally aminophylline as a nonselective phosphodiesterase inhibitor is used. (org.ir)
Pharmaceutical1
- Aminophylline can be used as dicuretic and helping to relax the smooth muscle .The aminophylline can relax the bronchus and the smooth muscle of the blood vessel,inhibit the kidney tubules to reabsorb the sodium and the water and enhance the extraction of heart oedema and so on .It is mainly used in pharmaceutical field. (henrikangbio.com)
Dihydrate3
- Each mL contains: Aminophylline (calculated as the dihydrate) 25 mg (equivalent to 19.7 mg of anhydrous theophylline), and is intended for intravenous administration. (nih.gov)
- The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate. (wikipedia.org)
- AMINOPHYLLIN 250 mg/10 mL INJECTION contains 250 mg aminophylline dihydrate in 10 mL. (bushorchimp.com)
10mL2
- Each 10ml of solution contains aminophylline hydrate B.P. 250mg. (medicines.org.uk)
- Aminophylline Injection B.P. 250mg/10ml is for slow intravenous administration. (medicines.org.uk)
Adverse2
- Although further benefits from aminophylline in this setting might be shown by studies of much larger numbers of patients, these should be weighed against the demonstrated adverse effects. (annals.org)
- IV aminophylline requires careful titration and monitoring which does not always happen and may lead to adverse effects. (ersjournals.com)
Overdose3
- Aminophylline or theophylline overdose occurs when someone takes more than the normal or recommended amount of these medicines. (medlineplus.gov)
- Aminophylline overdose for children' my kid is 2 years old and took aminophylline 350 instead of 125 for two days twice daily what's longterm sideeffe? (healthtap.com)
- Get emergency assistance as soon as possible if you have any of these overdose symptoms while taking Aminophylline. (healthery.com)
Anhydrous2
- The molecular formula of anhydrous aminophylline is C16H24N10O4 with a molecular weight of 420.43. (nih.gov)
- If this is not possible and if the clinical situation requires that the drug be administered, a dose of 3.1 mg/kg of aminophylline (equivalent to 2.5mg/kg of anhydrous theophylline) may be considered on the basis that it is likely to increase the serum theophylline concentration by approximately 5mcg/ml when administered as a loading dose. (medicines.org.uk)
Infusion2
- AMINOPHYLLINE INJECTION USP is administered by I.V. injection or infusion. (sgpharma.com)
- The effects of intravenous infusion of aminophylline on respiratory muscle interaction were examined in seven normal subjects breathing at rest. (elsevier.com)
Injection USP1
- AMINOPHYLLINE INJECTION USP is a sterile, clear to slightly yellow colourless solution filled in ampoule of suitable size. (sgpharma.com)
Treatment9
- Aminophylline is also a treatment option for anaphylactic shock. (wikipedia.org)
- You may need a dose adjustment if you have been receiving aminophylline and are starting treatment with sarilumab. (drugs.com)
- Aminophylline has not been proven to be safe or a helpful treatment for bladder cancer. (clinicaltrials.gov)
- To determine the efficacy of intravenous aminophylline in the treatment of patients hospitalized for exacerbation of chronic obstructive pulmonary disease. (annals.org)
- We were unable to show that the administration of parenteral aminophylline provides significant additional benefits when added to an otherwise standard treatment regimen in patients with chronic obstructive pulmonary disease exacerbations. (annals.org)
- Treatment with aminophylline induces the expression of transcriptional coactivator PGC-1α and transcriptional factors NRF1 and TFAM, which requires the activation of the CREB-PGC-1a signaling pathway by aminophylline. (statpearls.com)
- Treatment with aminophylline and isoproterenol improved the overall blood flow in the spinal cord. (elsevier.com)
- After six days of treatment with aminophylline, the brain stem conduction time (interpeak latency of I-V) in apnoeic infants decreased compared with controls of a similar post-conceptional age. (elsevier.com)
- No significant differences were found in the latencies of BAEPs between the apnoeic infants who responded and those who did not respond to aminophylline treatment, however. (elsevier.com)
Respiratory3
- Aminophylline is a central respiratory stimulant and will decrease the incidence of PGE 1 -associated apnea and the need for intubation for apnea in infants with ductal-dependent congenital heart disease. (aappublications.org)
- Concurrent with the discovery of the utility of PGE 1 in ductal-dependent neonates, aminophylline was reported to be a useful respiratory stimulant in premature neonates with apnea of prematurity. (aappublications.org)
- Aminophylline was chosen as a respiratory stimulant for this study because of its excellent safety profile and low cost of serum level assays. (aappublications.org)
Arrhythmias1
- This study aimed to evaluate and compare the effects of fast and slow aminophylline injections on electrocardiographic parameters and arrhythmias in neonate rats. (org.ir)
COPD1
- IV Aminophylline is commonly used in patients presenting with acute exacerbations of COPD (AECOPD). (ersjournals.com)
Evaluate1
- The aim of this study is to evaluate and compare the effect of ondansetron and aminophylline on PDPH. (alliedacademies.org)
Relaxes1
- Aminophylline relaxes the muscles in the airways and opens air passages for better breathing. (healthery.com)
Drug5
- Aminophylline was given as an initial 6 mg/kg intravenous bolus, followed by a 2 mg/kg intravenous dose every 8 hours for 72 hours, at which time the study drug was discontinued. (aappublications.org)
- Patients who have early stage bladder cancer and will be receiving BCG, a bladder cancer therapy as recommended by a doctor, will be asked to participate in a study where they are given the standard BCG followed by the experimental drug, aminophylline. (clinicaltrials.gov)
- Aminophylline is a drug combination of theophylline and ethylenediamine in a ratio of 2 to 1. (statpearls.com)
- aminophylline is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
- Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109282/all/aminophylline. (unboundmedicine.com)
Oral1
- 13 strengths of Aminophylline Oral Suspension are available, ranging from 16 mg/ml to 300 mg/ml. (wedgewoodpharmacy.com)
Pharmacological1
- Objectives To establish whether aminophylline, administered at usual doses for rodents in pharmacological studies, induces brain injury in systemic hypoxaemia in guinea-pigs. (wiley.com)
Induces1
- Conclusions Aminophylline potentially induces brain damage under hypoxic conditions. (wiley.com)
Acutely1
- To test the hypothesis that aminophylline acutely impairs pulmonary antibacterial defenses, mice were challenged by aerosol inhalation with Staphylococcus aureus or Proteus mirabilis and injected intraperitoneally with aminophylline (20, 40, or 80 mg/kg). (elsevier.com)