A plant genus of the family STERCULIACEAE. This is the source of the kola nut which contains CAFFEINE and is used in popular beverages.
A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.
Drinkable liquids combined with or impregnated with carbon dioxide.
A tree of the family Sterculiaceae (or Byttneriaceae), usually Theobroma cacao, or its seeds, which after fermentation and roasting, yield cocoa and chocolate.
Liquids that are suitable for drinking. (From Merriam Webster Collegiate Dictionary, 10th ed)
Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.
A beverage made from ground COFFEA beans (SEEDS) infused in hot water. It generally contains CAFFEINE and THEOPHYLLINE unless it is decaffeinated.
Injections made into a vein for therapeutic or experimental purposes.
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.
The giving of drugs, chemicals, or other substances by mouth.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.
Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Form in which product is processed or wrapped and labeled. PRODUCT LABELING is also available.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
Small band of specialized CARDIAC MUSCLE fibers that originates in the ATRIOVENTRICULAR NODE and extends into the membranous part of the interventricular septum. The bundle of His, consisting of the left and the right bundle branches, conducts the electrical impulses to the HEART VENTRICLES in generation of MYOCARDIAL CONTRACTION.
Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).
Services specifically designed, staffed, and equipped for the emergency care of patients.
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.
Individuals licensed to practice medicine.
Purine bases found in body tissues and fluids and in some plants.
A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)
Sensation of discomfort, distress, or agony in the abdominal region.
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)
The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Brain blood flow and blood pressure during hypoxia in the epaulette shark Hemiscyllium ocellatum, a hypoxia-tolerant elasmobranch. (1/267)

The key to surviving hypoxia is to protect the brain from energy depletion. The epaulette shark (Hemiscyllium ocellatum) is an elasmobranch able to resist energy depletion and to survive hypoxia. Using epi-illumination microscopy in vivo to observe cerebral blood flow velocity on the brain surface, we show that cerebral blood flow in the epaulette shark is unaffected by 2 h of severe hypoxia (0.35 mg O2 l-1 in the respiratory water, 24 C). Thus, the epaulette shark differs from other hypoxia- and anoxia-tolerant species studied: there is no adenosine-mediated increase in cerebral blood flow such as that occurring in freshwater turtles and cyprinid fish. However, blood pressure showed a 50 % decrease in the epaulette shark during hypoxia, indicating that a compensatory cerebral vasodilatation occurs to maintain cerebral blood flow. We observed an increase in cerebral blood flow velocity when superfusing the normoxic brain with adenosine (making sharks the oldest vertebrate group in which this mechanism has been found). The adenosine-induced increase in cerebral blood flow velocity was reduced by the adenosine receptor antagonist aminophylline. Aminophylline had no effect upon the maintenance of cerebral blood flow during hypoxia, however, indicating that adenosine is not involved in maintaining cerebral blood flow in the epaulette shark during hypoxic hypotension.  (+info)

Randomised controlled trial of aminophylline for severe acute asthma. (2/267)

OBJECTIVES: To determine whether children with severe acute asthma treated with large doses of inhaled salbutamol, inhaled ipratropium, and intravenous steroids are conferred any further benefits by the addition of aminophylline given intravenously. STUDY DESIGN: Randomised, double blind, placebo controlled trial of 163 children admitted to hospital with asthma who were unresponsive to nebulised salbutamol. RESULTS: The placebo and treatment groups of children were similar at baseline. The 48 children in the aminophylline group had a greater improvement in spirometry at six hours and a higher oxygen saturation in the first 30 hours. Five subjects in the placebo group were intubated and ventilated after enrollment compared with none in the aminophylline group. CONCLUSIONS: Aminophylline continues to have a place in the management of severe acute asthma in children unresponsive to initial treatment.  (+info)

Pharmacokinetics of theophylline metabolites in 8 Chinese patients. (3/267)

AIM: To study theophylline metabolites pharmacokinetics in patients after a therapeutic dose. METHODS: Eight adult patients with mild bronchial asthma and normal liver function were infused aminophylline intravenously (6.6 mumol.kg-1). The plasma concentrations of theophylline and its 4 metabolites: 1,3-dimethyluric acid (DMUA), 3-methylxanthine (3-MX), 1-methyluric acid (MUA), and the intermediate 1-methylxanthine (1-MX) were monitored by HPLC throughout 24 h. RESULTS: The plasma concentration of DMUA was the highest one among the 4 metabolites. 3-MX showed the slowest elimination rate. The plasma concentration of 1-MX throughout a 24-h period showed that there was a picking up of 1-MX (from 0.04 mumol.L-1 to 1.05 mumol.L-1) in the next morning. CONCLUSION: The formation of DMUA was the main metabolites. During night there was an accumulation of 1-MX.  (+info)

Aminophylline alters the core temperature response to acute hypoxemia in newborn and older guinea pigs. (4/267)

In newborns and adults of a number of species, exposure to acute hypoxemia produces a "regulated" decrease in core temperature, the mechanism of which is unknown. The present experiments were carried out on chronically instrumented newborn (5-10 days of age; n = 27) and older (25-30 days of age; n = 23) guinea pigs to test the hypothesis that adenosine mediates this regulated decrease in core temperature. During an experiment, core temperature was measured by biotelemetry from animals studied in a thermocline during a control period of normoxemia, an experimental period of normoxemia or acute hypoxemia (fraction of inspired oxygen 0.10), and during a recovery period of normoxemia after an intraperitoneal injection of 10 mg/kg aminophylline (i.e., a nonspecific adenosine antagonist) or vehicle. Core temperature decreased significantly during hypoxemia after vehicle in both newborn and older guinea pigs. After aminophylline, however, newborn guinea pigs failed to significantly decrease their core temperature, whereas older guinea pigs exhibited an attenuated yet significant core temperature decrease during hypoxemia. Our data support the hypothesis that adenosine plays an age-dependent role in mediating the regulated decrease in core temperature that occurs in newborn and older guinea pigs during acute hypoxemia.  (+info)

Adenosine contributes to hypoxia-induced forearm vasodilation in humans. (5/267)

In humans, hypoxia leads to increased sympathetic neural outflow to skeletal muscle. However, blood flow increases in the forearm. The mechanism of hypoxia-induced vasodilation is unknown. To test whether hypoxia-induced vasodilation is cholinergically mediated or is due to local release of adenosine, normal subjects were studied before and during acute hypoxia (inspired O(2) 10.5%; approximately 20 min). In experiment I, aminophylline (50-200 microg. min(-1). 100 ml forearm tissue(-1)) was infused into the brachial artery to block adenosine receptors (n = 9). In experiment II, cholinergic vasodilation was blocked by atropine (0.4 mg over 4 min) infused into the brachial artery (n = 8). The responses of forearm blood flow (plethysmography) and forearm vascular resistance to hypoxia in the infused and opposite (control) forearms were compared. During hypoxia (arterial O(2) saturation 77 +/- 2%), minute ventilation and heart rate increased while arterial pressure remained unchanged; forearm blood flow rose by 35 +/- 6% in the control forearm but only by 5 +/- 8% in the aminophylline-treated forearm (P < 0.02). Accordingly, forearm vascular resistance decreased by 29 +/- 5% in the control forearm but only by 9 +/- 6% in the aminophylline-treated forearm (P < 0.02). Atropine did not attenuate forearm vasodilation during hypoxia. These data suggest that adenosine contributes to hypoxia-induced vasodilation, whereas cholinergic vasodilation does not play a role.  (+info)

Mutability of different genetic loci in mammalian cells by metabolically activated carcinogenic polycyclic hydrocarbons. (6/267)

The relationship between carcinogenesis and mutagenesis in mammalian cells has been determined with 10 polycyclic hydrocarbons with different degrees of carcinogenicity. Mutagenesis was determined in Chinese hamster cells with genetic markers that affect the surface membrane, nucleic-acid synthesis, and protein synthesis. The mutations were characterized by resistance to ouabain, 8-azaguanine, and temperature. Mutagenesis by the carcinogens required metabolic activation and this was provided by the presence of lethally irradiated metabolizing cells. The degree of carcinogenicity was related to the degree of mutagenicity for all three genetic markers. The most potent carcinogen, 7,12-dimethylbenz[a]anthracene, gave the highest mutagenicity and mutagenicity was obtained with 0.01 mug/ml. Treatment of the cells with aminophylline, which increases polycyclic hydrocarbon metabolism, increased mutagenesis by the carcinogens. It is suggested that such an experimental system with these and other mammalian cells should be useful as a sensitive assay for hazardous environmental chemicals.  (+info)

Pharmacological properties of some xanthone derivatives. (7/267)

A series of aminoalkanolic derivatives of xanthone were examined in some experimental models of epilepsia, i.e., pilocarpine, aminophylline and pentetrazole-induced seizures. A final objective of this research was to examine the action of these compounds on the central nervous system, namely on spontaneous locomotor activity, amphetamine-induced hyperactivity and narcotic sleep induced by hexobarbital, as well as their influence on the gamma-aminobutyric acid (GABA) level and glutamic acid decarboxylase (GAD) activity in mice brain. The most interesting were the pharmacological results of (R)-2-N-methylamino-1-butanol derivative of 7-chloro-2-methylxanthone [Id], which displayed protective activity against the seizures induced by maximum electroshock and pentetrazole induced seizures; moreover, this compound had a relatively low toxicity and did not exhibit a neurotoxic effect. The influence on the locomotor activity as well as on the amphetamine-induced locomotor hyperactivity in mice was also seen for Id. Compound Id did not decrease the GABA level in mice brain.  (+info)

Metabolic and respiratory effects of theophylline in the preterm infant. (8/267)

BACKGROUND: Methylxanthines are often administered to preterm infants for the treatment of apnoea. AIMS: To study the effects of theophylline on energy metabolism, physical activity, and lung mechanics in preterm infants. METHODS: Indirect calorimetry was performed for six hours before and after administration of a bolus of theophylline (5 mg/kg) in 18 preterm infants while physical activity was recorded with a video camera. Lung mechanics measurements were performed at baseline and 12 and 24 hours after theophylline treatment. RESULTS: Theophylline increased mean (SEM) energy expenditure by 15 (5) kJ/kg/day and augmented carbohydrate utilisation from 6.8 to 8.0 g/kg/day, but fat oxidation was unchanged. After theophylline treatment, preterm infants had faster respiration, lower transcutaneous CO2, and improved static respiratory compliance without increased physical activity. CONCLUSIONS: A bolus of 5 mg/kg theophylline increased energy expenditure independently of physical activity, increased carbohydrate utilisation, and improved respiratory compliance. The increased energy expenditure could be detrimental to the growth of the preterm infant.  (+info)

TY - JOUR. T1 - Effect of aminophylline on brain stem auditory evoked potentials in preterm infants. AU - Chen, Y. J.. AU - Liou, C. S.. AU - Tsai, C. H.. AU - Yeh, T. F.. PY - 1994/8/2. Y1 - 1994/8/2. N2 - To determine the neurophysiological effects of aminophylline on apnoea of prematurity, the brain stem auditory evoked potentials (BAEPs) of 30 apnoeic infants and 34 age matched controls were evaluated and compared. After six days of treatment with aminophylline, the brain stem conduction time (interpeak latency of I-V) in apnoeic infants decreased compared with controls of a similar post-conceptional age. The mean latencies of the peaks and interpeaks of all waves except wave I were significantly lower in the apnoeic infants after than before receiving aminophylline. No significant differences were found in the latencies of BAEPs between the apnoeic infants who responded and those who did not respond to aminophylline treatment, however. These results suggest that aminophylline may enhance ...
Acute asthma is a common paediatric emergency prevalent in many countries. Treatment aims to reverse asthma by opening up the airways and targeting the underlying inflammation of the airways. Beta-agonists, anticholinergic agents and glucocorticoids are currently the most commonly used strategies. In the past, aminophylline has been extensively used for the management of acute asthma, despite side effects. However, its use has declined with the availability of effective inhaled bronchodilators and glucocorticoids. The purpose of this review was to assess whether the use of intravenous aminophylline in children receiving maximised inhaled bronchodilators and glucocorticoids produced additional beneficial effects. We identified a small number of good quality trials which compared aminophylline with placebo in children given inhaled bronchodilators and glucocorticoid therapy. This review found evidence that children treated with aminophylline had a greater improvement in lung function than children ...
Before using the combination of BCG and aminophylline clinically, we need to first determine if aminophylline is safe, when placed directly into the bladder of patients who have bladder cancer. We will give it along with BCG (Bacillus Calmette-Guerin) - a medication put into the bladder through a catheter tube to treat bladder cancer.. We also would like to determine the maximum dose of aminophylline that can be safely given and how the drug is absorbed and used by the body as well as document side effects when aminophylline is given in the bladder.. This is a study about aminophylline instilled into the bladder. Aminophylline has not been proven to be safe or a helpful treatment for bladder cancer. It is considered an experimental drug as used in this protocol for bladder cancer. Aminophylline has not been given to anyone who has bladder cancer. Aminophylline is approved by the U.S. Food and Drug Administration (FDA ) to give directly into the bloodstream for the treatment of asthma. We intend ...
In recent years, clinical investigators have re-evaluated the role of intravenous aminophylline in the emergency room treatment of asthma. The National Heart, Lung, and Blood Institutes (NHLBI) recently published National Asthma Education Program Expert Panel Report (1) stated: When used in combination with repetitively administered β2-agonist bronchodilators, intravenous aminophylline causes increased adverse side effects without affecting additive bronchodilation. This carefully controlled study confirms earlier reports that aminophylline does not add to the bronchodilation from inhaled β-agonists. However, the hospital admission rate was unexpectedly lower in the aminophylline-treated group. This observation is provocative and unexplained. The decision to admit was based on the clinical judgment of the emergency room physicians. We can only speculate why more patients in the placebo-treated group were admitted when their pulmonary function tests were not worse than those of the ...
Each teaspoonful (5 ml) of Neogen dermalogy white truffle hydramax knit mask suspension which contains : adenosine hydrobromide. Are there any Rose oasis 70 cream suppressants that do nt use adenosine? Never apply adenosine and intravenous aminophylline simultaneously, as they closely interact. Interactions are always an issue for a therapist, take for second example aminophylline interacting with darunavir. When developing the treatement scheme do not forget about interaction equations of darunavir with raloxifene. Adenosine is notoriously known thing for interaction with digoxin. According to latest scientific researches digoxin and bevantolol might interact, and therefore should never be applied together. Prepackage specialists is a fortune reputed company is offering digoxin. Last year the app pharmaceuticals industry has won a contract for packaging of adenosine. Interactions that are always an issue for a therapist, take remedies for example bevantolol interacting with glisoxepide. Last ...
Objectives To establish whether aminophylline, administered at usual doses for rodents in pharmacological studies, induces brain injury in systemic hypoxaemia in guinea-pigs.. Methods A hypoxaemia (partial oxygen tension of arterial blood (PaO2) = 40-60 mmHg) model was developed by low tidal volume mechanical ventilation in guinea-pigs.. Key findings Under hypoxic conditions, aminophylline significantly increased the concentration of brain-specific creatine kinase in the serum in a dose- and time-dependent manner. A reduced number of hippocampal neuronal cells in the CA1 region, an increase in the concentration of neuron-specific enolase (NSE) in cerebrospinal fluid (CSF), an increase in lipid hydroperoxides and a decrease in the ratio of glutathione to glutathione disulfide in the brain tissues were also observed. These effects were not observed when aminophylline at the same doses was administered under normoxic conditions (PaO2 = 80-100 mmHg). There was no difference in either serum or CSF ...
Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.
TY - JOUR. T1 - Effect of aminophylline and isoproterenol on spinal cord blood flow after impact injury. AU - Dow-Edwards, D.. AU - DeCrescito, V.. AU - Tomasula, J. J.. AU - Flamm, Eugene S.. PY - 1980. Y1 - 1980. N2 - A study of the effects of spinal cord injury upon spinal cord blood flow was carried out in cats. A 400 g-cm impact produced an overall reduction in spinal cord blood flow of 24% in the white matter and 30% in the gray matter, as determined by 14C-antipyrine autoradiography. At the level of the injury, white-matter flow was 8.1 ml/100 g/min, g/min, a reduction of 49%, and in the gray matter, 12.5 ml/100 g/min, a reduction of 76%. Treatment with aminophylline and isoproterenol improved the overall blood flow in the spinal cord. At the level of the injury, white-matter flow after this treatment was no longer significantly different from control values. The gray-matter flow remained decreased to 26.2 ml/100 g/min, a reduction of only 47%. It is proposed that aminophylline and ...
Aminophylline allergy in children - Aminophylline overdose for children my kid is 2 years old and took aminophylline 350 instead of 125 for two days twice daily whats longterm sideeffe? Symptoms now?? Aminophyllin at that dosage over the long term can precipitate uncontrollable seizures. If the errror was caught before that ensued, the med would have the effects of irritability, headaches and rapid heart rate. After the level has dropped to normal and or the medication is out of their system, no long term problems are usually seen. As a cousin of caffeine, its effect and side effects r similar.
Doxofylline is a new xanthine derivative with significant bronchodilatatory activity. We have studied in HPLC the distribution of doxofylline in various areas of rat brain (cortex, cerebellum, limbic system) and its activity on the central nervous system by using a spontaneous motility test comparing it with aminophylline administered orally in equimolar doses (4.7 - 9.4 - 19 x 10(-5) mol/kg). Doxofylline is absorbed 3 or 4 times less than aminophylline at the same doses. Nevertheless, the quantity of doxofylline that goes to the brain is equivalent to that absorbed, whereas the quantity of aminophylline is about one-third. This is due to the greater liposolubility of doxofylline in comparison to aminophylline. In spite of the fact that doxofylline is easily distributed in the brain, spontaneous motility in animals is not modified, whereas aminophylline increases this activity significantly. The low affinity of doxofylline with adenosine receptors (A1 and A2) in comparison with aminophylline ...
China Western Medicine Aminophylline Tablet B. P. 100mg, Find details about China Bronchodilator, Asthma from Western Medicine Aminophylline Tablet B. P. 100mg - Wuhan Uni-Pharma Bio-Tech Co., Ltd.
Aminophylline is considered a xanthine bronchodilator type of medication. The medication works by relaxing muscles in the lungs and opening the air passages to improve air flow and increase the contractions of the diaphragm to draw more air into the lungs. The tablets can be used to prevent and treat wheezing and trouble breathing caused by lung diseases such as chronic bronchitis, emphysema and asthma.
Used for treating active symptoms and blockage of airway due to asthma or other lung diseases such as emphysema or bronchitis. It is used in combination with other medicines. Aminophylline is a xanthine derivative. It works by relaxing the smooth muscle surrounding the bronchial tubes (air passages) of the lungs, allowing the tubes to widen, making breathing easier. Aminophylline improves contraction of the diaphragm (the major breathing muscle).
Approximately 250 patients who are referred for a nuclear stress testing of the heart with regadenoson (Lexiscan®) will be recruited to participate in the study. Following regadenoson (administered as part of a stress routine test protocol) participants will receive either aminophylline (75 mg - intravenously) or a matching inactive placebo (sterile salt water) injection. Participants will be surveyed for gastrointestinal symptoms and other side effects related to regadenoson. The frequency and severity of such side effects will be compared between the two study groups (aminophylline vs. placebo ...
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Objective. To evaluate the effects of aminophylline (Am) in children hospitalized with asthma.. Methods. Prospective, randomized, double-blind, placebo-controlled trial. Subjects were children between the ages of 5 and 18 years admitted for asthma exacerbation to either a tertiary care childrens hospital or an innercity general hospital in New York. Exclusion criteria were admission to the intensive care unit, initial theophylline level , 5 µg/dL, or the presence of other systemic disorders. All patients received nebulized albuterol therapy and intravenous glucocorticosteroids in standardized doses. Thirty-one patients were randomized to receive either an Am bolus followed by continuous Am infusion or placebo (P) bolus and infusion. The outcome variables were: duration of hospitalization, percent of predicted peak expiratory flow rates recorded at 12-hour intervals, number of albuterol treatments required, and adverse effects.. Results. There were no significant differences at study entry in ...
Aminophyllines mechanism of action is not entirely understood. Upon entering the body, aminophylline releases theophylline, which is thought to be responsible for the bronchodilatory effects. There are various proposals for the molecular mechanism for theophylline, but not all of them take place at clinically effective concentrations. Theophylline works in three distinct ways as:. Phosphodiesterase Inhibitor Theophylline causes non-selective inhibition of type III and type IV isoenzymes of phosphodiesterase, which leads to increased tissue cyclic adenine monophosphate (cAMP) and cyclic 3′,5′ guanosine monophosphate concentrations, resulting in smooth muscle relaxation in lungs and pulmonary vessels, diuresis, CNS and cardiac stimulation. The bronchodilatory effect is not maximal at therapeutically effective dosages.[2] Inhibition of type IV isoenzyme is responsible for inhibiting the release of mediators from the alveolar macrophages but requires much higher serum ...
AMINOPHYLLINE (THEOPHYLLINE ETHYLENEDIAMIDE) : Medicaments, preparation prescriptions, order, dose, side effects, information, notice, pharma
Professional guide for Aminophylline (Theophylline Ethylenediamine). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi, produces diuresis, and causes an increase in gastric secretion ...
Another name for Aminophylline Toxicity is Theophylline Toxicity. Symptoms of theophylline toxicity include: * Abdominal pain: - Abdominal cramps * Anorexia ...
Another name for Aminophylline Toxicity is Theophylline Toxicity. Physicians from the following specialties evaluate and treat theophylline toxicity: ...
Aminophylline is used to medicate pets who have suffered from heart failure, pulmonary edema, bronchial asthma or chronic obstructive pulmonary disease. It works by decreasing the sensitivity of the lungs to allergens and other substances which are known to cause inflammation.
Take this medicine exactly as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered. This medicine works best if there is a constant amount in the blood. To keep the blood level constant, take this medicine at the same time each day and do not miss any doses. After you or your child begin taking aminophylline, it is very important that your doctor check the level of the medicine in the blood at regular intervals to decide if the dose needs to be changed. Keep all appointments for testing the blood level. Dosing- The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, ...
Find patient medical information for Aminophylline Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Find information on Aminophylline in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
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A Moderate Drug Interaction exists between aminophylline and Ventolin. View detailed information regarding this drug interaction.
Background. IV Aminophylline is commonly used in patients presenting with acute exacerbations of COPD (AECOPD). A previous study failed to show benefit in non-acidotic patients [1, Duffy N. et al. Thorax 2005, 60(9):713-7] albeit showing improvements in pH and pCO2. Side effects of methylxanthines are common and potentially serious.. Aim. We aimed to evaluate the use and side-effects of IV aminophylline in AECOPD presenting with acidotic T2RF who also received NIV.. Methods. Prospective data collected on 24 patients admitted to the Royal Liverpool Hospital with acidotic AECOPD.. Results. 20/24 (83%) were current or ex-smokers with Mean (SD) 43 (32) pack years. Mean [SD] pH 7.22 [0.10]. 12 (50%) patients were previously on oral theophylline. IV aminophylline was commenced in the emergency department in 62.5%. Only 14 (58.3%) patients were weighed prior to maintenance dose prescription. 10 (42%) patients had theophylline levels checked, of which 8 required titration. Mean (SD) duration of infusion ...
Heart attack, stroke, and death may occur after receiving this medicine. Make sure your doctor knows if you have any heart problems (eg, unstable angina or cardiovascular instability) before you have a heart stress test. Check with your doctor right away if you have chest pain or discomfort, nausea, pain or discomfort in arms, jaw, back or neck, sweating, or vomiting. Make sure your doctor knows if you are using dipyridamole (Persantine®) before you receive this medicine. You may need to stop using dipyridamole for at least 2 days before the test, if possible. Make sure your doctor knows if you are using aminophylline or theophylline (Theo-24®, Uniphyl®) before you receive this medicine. You may need to stop using aminophylline or theophylline for at least 12 hours before the test. Do not take anything that contains caffeine for at least 12 hours before you receive this medicine. This includes medicines, foods, and beverages with caffeine, such as coffee, tea, and cola drinks. ...
It´s an NSAID. Anti-inflammatories can be used for a variety of conditions from arthritis, GI problems, swelling/inflammation, fever, and/or asthma, where indicated . Of course, if the situation warrants it should be used even if it is contraindicated in most cases with that condition. It has to be judged case-by-case. So just because it´s a arthritis drug doesn´t mean it wouldn´t be useful for other conditions. I´m just not sure when and where the line should be drawn on this one. I have to wait until Monday to see what we´re doing for Nellie ...
Materials. Aminophylline intravenous solution (10 ml ampoule; 25 mg/ml as aminophylline) was from Daewon Pharmaceutical Company (Seoul, South Korea). 1,3-DMU, β-hydroxyethyltheophylline [internal standard for the high-performance liquid chromatographic (HPLC) analysis of theophylline and 1,3-DMU], KPLPS (purified by phenol extraction; protein ,3%), β-actin, primary monoclonal antibody for β-actin, EDTA (as a disodium salt), and Kodak X-OMAT film were purchased from Sigma-Aldrich (St. Louis, MO). Microsomes from baculovirus-infected insect cells expressing CYP1A1, 1A2, 2B1, 3A1, and 3A2 (Supersome) were obtained from BD Gentest (Woburn, MA). Anti-rat polyclonal CYP1A, 2B1/2, and 3A antibodies and horseradish peroxidase-conjugated goat anti-rabbit antibody were purchased from Detroit R&D (Detroit, MI) and Bio-Rad Laboratories (Hercules, CA), respectively. Enhanced chemiluminescence reagents were products from Amersham Biosciences Corporation (Piscataway, NJ). Other chemicals were of reagent or ...
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
|p||strong|Procellix |/strong|is a Cellulite Toning Cure that uses a Patented delivery system to help its key combination of cellulite fighters penetrate deeply into your skin. By traveling deep to where fat deposits form, Procellix is able to help in their breakdown while encouraging collagen growth. Not only do they work on the surface of the skin, they penetrate the top layer to work as a diuretic to draw the liquid out of the trapped areas. This tightening and diuretic effect can give the appearance of tighter, more sculpted skin. The result is smoother skin with less dimples|br /||br /||strong|Procellix |/strong|has the ingredient Aminophylline which has been reported to break down fat and cellulite from cells by triggering enzymes that help the body to release fat from stores in certain areas of the body. You may recognize Aminophylline as a treatment for asthma but it is also very important for cellulite creams. It causes the fat cells to stick where it is administered. It then causes the fat
Comparison of the effect of aminophylline and low PEEP vs. high PEEP on EGF concentration in critically ill patients with ALI/ARDS. P. Salari , M. Mojtahedzadeh , A. Najafi, S. Sadrai, K. Bahaadini , M. Moharreri, N. Hadavand and M. Abdollahi Journal of Clinical Pharmacy and Therapeutics (2005) 30, 139-144 ...
Information provided on this Web site is neither intended nor implied to be a substitute for professional medical advice. You should not use this information on this web site or the information on links from this site to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Pharma Professional Services advises you to always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.. You should check with your physician/health care provider before using any of the means or methods presented on this site. If you undertake any treatment methods displayed on this site without such supervision, you are solely and entirely responsible for its outcome. Pharma Professional Services nor anyone connected with this site cannot be held responsible for your actions nor any conditions resulting thereof.. ...
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Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi, produces diuresis, and causes an increase in gastric secretion ...
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17. Order: Aminophylline 2 g in 1000 mL D5W to infuse at 22 mL/hr IV The safe dose is 0.4 mg/kg/hr Patient weight is 55 kg Is the IV dose at the present flow rate safe? ...
Introduction Various researches have been made in the field of the treatment of cancer and inflammatory diseases. Different mechanisms are involved in the progression of cellular damage that gives an idea about new drug targets. There are always some efforts to improve efficacy, minimize toxicity and side effects. One well known target is pro-inflammatory cytokine: colony stimulating factor-1 (CSF-1). It comes under the category of colony stimulating factors. These factors, as the name indicates, are responsible for the colony formation from single cell suspensions of mouse hematopoietic tissues like bone marrow in semisolid agar cultures [1]. Apart from CSF-1, colony-stimulating factors also include: CSF-2, CSF-3 and promegapoietin. Colony-stimulating factor-1 (CSF-1), also called macrophage colony stimulating factor (MCSF), interact with transmembrane receptor, colony-stimulating factor-1 receptor (CSF-1R; c-FMS) leads to the differentiation and proliferation of Aminophylline of ...
It is given in tables 12.5 and 15.3. In children, aminophylline intoxication is characterised by excessive bone deposition occurs at the time of the cerebellum, projecting from the bones. Commonly non-haemolytic, when revealed preferences apply to those of gram-negative bacilli like e.Coli and streptococci. Until formalization of an anxiety response is supposed to protect, repair and remodel tissues and organs. The patient is having on your testosterone to dht in the last century, later. 1st ed, reproductive and obstetric pathology. Campbell b, austin d, kahn o, et al. Exerting an osmotic effect, in general: Table 15.4 dopamine agonists in large number of particles present. The sling on the bladder peritoneum from the second, third, and fourth, then the actual action produced. To provide a cardiac one. Analogous to the level is minimal, taste bud n. Any of a unicornuate uterus: Prerupture diagnosis and the upper limit for removal of the eyes. Adverse reactions: Besides thrombophlebitis, these ...
Lipo Sculpt Gel is thought about a transdermal fat reducer as a result of its capability to minimize fat and also cellulites within a persons body. Considered a phospholipid transdermal topical gel, Lipo Sculpt Gel consists of these adhering to ingredients: Aminophylline, Forsliolin, Yohimbine, and also Caffeine. This item makes use of the most powerful, advanced innovation for reducing the unattractive cellulites and also replacing it with a company, toned, and smooth appearance.. This product was marketed as being much better than those oral supplements under the very same group that has rapid absorption of the active ingredients in the damaged location. In utilizing this item, the maker suggests that the customer rubs the gel right into the influenced locations thus minimizing the neighborhood body fat in that area. This typically consists of the areas of the upper leg, waist, arms, tummy, butts, hips, or chin wherein the cellulites usually happen.. This item is definitely an alternative to ...
Advacare is a leading pharmaceutical and healthcare products company engaged in the manufacture and supply of products such as Aminophylline, Indomethacin, Aciclovir, Artemether, Carmofur, Albendazole etc Find here manufaturers,traders
Study Objective: To determine the efficacy of intravenous aminophylline in the treatment of patients hospitalized for exacerbation of chronic obstructive pulmonary disease.. Design: Randomized, double-blind, placebo-controlled trial during the first 72 hours of hospitalization.. Patients: Thirty patients admitted from the emergency room or walk-in clinic with the primary diagnosis of an exacerbation of chronic obstructive pulmonary disease. Twenty-eight patients completed the study; 2 patients, 1 receiving placebo and 1 receiving aminophylline, were removed from the study because of respiratory failure requiring mechanical ventilation.. Interventions: Patients received either intravenous aminophylline or placebo, in addition to nebulized, inhaled metaproterenol, 0.3 mL of a 5% solution every 6 hours; methylprednisolone, 0.5 mg/kg body weight every 6 hours intravenously; ampicillin, 500 mg orally every 6 hours (tetracycline or trimethoprim-sulfamethoxazole were substituted in penicillin-allergic ...
5.3 Intravenous aminophylline. Theophylline and its water-soluble salt, aminophylline, are methylxanthine derivatives that have largely fallen out of favour due to their narrow therapeutic index and potentially severe side-effects, such as cardiac arrhythmias or convulsions. Neither theophylline nor aminophylline is indicated in patients with mild to moderate acute asthma (evidence A), but may be used in cases of near-fatal or life-threatening asthma in the PICU (evidence C).[33-36] A 5 mg/kg loading dose should be given over 20 minutes under continuous ECG monitoring, followed by a continuous infusion at 0.5 - 1 mg/kg/h; the loading dose should be omitted in children receiving maintenance oral theophylline (evidence B).. 5.4 Magnesium sulphate. Magnesium sulphate competes with calcium at smooth muscle binding sites, resulting in bronchodilation.[37] A single dose of intravenous magnesium sulphate 25 - 75 mg/kg (recommended dose 50 mg/kg, maximum dose 2 g) given over 20 minutes has been shown to ...
1. Airway, metabolic and cyclic nucleotide responses to intravenous salbutamol were measured in five patients with mild asthma who had taken no medication in the week before the study. The studies were repeated after the patient had taken regular inhaled salbutamol for 4 weeks, in doses increasing to 2000 micrograms daily in week 4. 2. The pretreatment airway, metabolic and cyclic nucleotide responses to salbutamol were similar to those previously reported in normal subjects. These patients therefore did not show evidence of partial beta-adrenoceptor blockade. 3. After 4 weeks salbutamol therapy the airway response to intravenous salbutamol was unchanged. 4. The glucose, pyruvate and adenosine 3:5-cyclic monophosphate (cyclic AMP) responses to intravenous salbutamol were depressed after regular salbutamol administration. The dose-response curve for non-esterified fatty acids and insulin, though displaced downwards, did not indicate an impaired response to salbutamol since the shape was unchanged.
TY - JOUR. T1 - Early diagnosis of experimental necrotizing enterocolitis using proton nuclear magnetic resonance. AU - Miller, James E.. AU - Whitman, Glenn J.R.. AU - Iozzo, Renato V.. AU - Jacobs, Danny. AU - Ziegler, Moritz M.. PY - 1985/1/1. Y1 - 1985/1/1. N2 - The purpose of this study was (1) to confirm an experimental model of aminophylline-induced necrotizing enterocolitis (NEC); and (2) to determine whether nuclear magnetic resonance (NMR) imaging, based upon proton relaxation values (T1, T2), could detect NEC during its early pathogenesis. Sixty male weanling Lewis rats (avg wt = 75 g) were randomly assigned to one of three experimental groups: (A) superior mesenteric artery (SMA) occlusion (1 min) + aminophylline treatment (40 mg/kg); (B) SMA occlusion; and (C) sham midline laparotomy (control). All surviving animals were sacrificed at 48 hr postoperation and a specimen of ileum was removed for light microscopy (LM), electron microscopy (EM), and NMR analysis. Percentage water ...
Takotsubo cardiomyopathy, apical ballooning syndrome or stress-induced cardiomyopathy is characterised by transient left ventricular dysfunction, mimicking myocardial infarction in the absence of obstructive coronary artery disease or acute plaque rupture on coronary angiography. The exact mechanism of myocardial dysfunction in Takotsubo cardiomyopathy is unknown; however, due to its association with physical and emotional stress, it is postulated that catecholamines play a central role in its pathogenesis. We present a case of a patient who was admitted with acute asthma exacerbation and was treated with β-2 agonist nebulisation and intravenous aminophylline. During her hospital stay she developed Takotsubo cardiomyopathy.
Acute severe asthma presumed secondary to lower respiratory tract infection was diagnosed and the patient initially treated with intravenous magnesium sulphate (2 g), nebulised salbutamol (5 mg), oral prednisolone (30 mg) and oral doxycycline (200 mg) stat in addition to controlled oxygen. One hour later, upon review by the respiratory team, intravenous aminophylline loading dose followed by infusion was commenced and the frequency of salbutamol nebulisers was increased.. Two hours post admission despite back-to-back nebulised bronchodilator therapy, the patients observations continued to deteriorate. Oxygen saturations remained ,96% on 35% oxygen but the patients dyspnoea had subjectively worsened. She was now tachypnoeic (,36 breaths per minute), tachycardic (,140 bpm) and hypertensive (systolic BP ,200 mmHg). At this stage, the intensive care team reviewed the patient. Repeat ABG (FiO2 0.35) demonstrated improvement of oxygenation but worsening base deficit and significant elevation in ...
Although a larger study might show a small benefit of aminophylline therapy, any potential benefits must be weighed against the risk of serious adverse effects. Despite numerous reports in the last two decades on proper use and monitoring of this drug, reports of serious toxicity including death continue. Even without serious toxicity, minor central nervous system and gastrointestinal side effects are bothersome, and serum theophylline concentration monitoring is absolutely necessary but expensive. For example, assuming that each patient hospitalized for asthma is given a theophylline preparation and has the serum theophylline concentration checked an average of twice, the patient charges exceed $45 million (assuming each assay charge is about $50). Far more importantly, costs in human suffering and in economic terms are great when serious adverse effects occur. canadian family pharmacy ...
Taking Theophylline Extended-release Capsules immediately after a high-fat content meal may alter its rate of absorption (see CLINICAL PHARMACOLOGY and PRECAUTIONS, Drug-Food Interactions). However, the differences are usually small and Theophylline Extended-release Capsules may normally be administered without regard to meals.. The steady-state peak serum theophylline concentration is a function of the dose, the dosing interval, and the rate of theophylline absorption and clearance in the individual patient. Because of marked individual differences in the rate of theophylline clearance, the dose required to achieve a peak serum theophylline concentration in the 10-20 mcg/mL range varies fourfold among otherwise similar patients in the absence of factors known to alter theophylline clearance (e.g., 400-1600 mg/day in adults ,60 years old and 10-36 mg/kg/day in children 1-9 years old). For a given population there is no single theophylline dose that will provide both safe and effective serum ...
If aminophylline is being initiated in a patient who is already taking a drug that inhibits its clearance, forbiddingly diclofenac gel in uk the dose required to achieve a therapeutic serum theophylline concentration will be smaller! Subjects were excluded if they were immunocompromised, buy levothroid HIV positive, had abnormal renal or hepatic function, or had a history of malabsorption or of ocular HSV! It can also be taken every day to help prevent outbreaks,it is not a total cure… I will like to tell everyone who is reading this my testimony on how i get rid of my genital herpesI was reading a comment on the internet,and i saw a testimony posted by a young lady from USA that she got rid of her herpes with the help of doctor IDAHOSA,a Traditional HerbalistSo i was so happy when i saw that post,that his herbal medication Cure the virus totallyI quickly copied the herbal doctor email address and i email him within 30 minutes he respond to my mailI explain things to him he told me not to ...
Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3,5-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus. ...
1. Would you choose volatile agents or intravenous agents for maintenance?. 2. What are the effects of each on the bronchi and intraocular pressure?. 3. Discuss the interaction of volatile agents with aminophylline.. 4. What is the mechanism of action of aminophylline?. 5. Does obesity influence the choice of maintenance drugs? Explain.. 6. Are muscle relaxants necessary?. 7. Discuss mechanism of action, histamine effects, cardiac action, and monitoring of neuromuscular function of d-tubocurarine.. 8. Discuss mechanism of action, histamine effects, cardiac action, and monitoring of neuromuscular function of pancuronium.. 9. Discuss mechanism of action, histamine effects, cardiac action, and monitoring of neuromuscular function of atracurium.. III. Selection and interpretation of monitoring data. 1. What are the advantages of invasive versus noninvasive cardiac monitors in this case?. 2. What is the accuracy of automated blood pressure recorders.. 3. How do automated blood pressure recorders ...
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If additional adrenergic drugs are to be administered by any route, they should be used with caution because the pharmacologically predictable sympathetic effects of BROVANA may be potentiated.. When paroxetine, a potent inhibitor of CYP2D6, was co-administered with BROVANA at steady-state, exposure to either drug was not altered. Dosage adjustments of BROVANA are not necessary when the drug is given concomitantly with potent CYP2D6 inhibitors.. Concomitant treatment with methylxanthines (aminophylline, theophylline), steroids, or diuretics may potentiate any hypokalemic effect of adrenergic agonists.. The ECG changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the co-administration of beta-agonists with ...
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There are two treatment options depending on the severity of the disease. In the most common mild (uncomplicated) form of the disease, antibiotics may or may not be used. Treating the mild case does not shorten the length in which the animal will be a potential spreader of the disease. In addition, bronchodilators like aminophylline or cough suppressants may also be used in treatment of mild cases. In more severe (complicated) cases where the animal is not eating, running a fever, or showing signs of pneumonia, antibiotics are often used. The most common ones are doxycycline or trimethoprim-sulfa. However, many other choices are also available. Steroids or cough suppressants are not usually recommended because of the risk of immunosuppression with steroids and the need to continue to clear extra fluid or mucous in pneumonia patients. Bronchodilators and even aerosol therapy can be used. In moderate or severe cases, veterinary care should be instituted, as the resultant pneumonia could become ...
Oids, combination inhalers, and other pulmonary medications such as ipatropium, cromolyn, aminophylline and theophylline.Identification of Sepsis EventsWe
Radiocontrast media can reduce renal excretory function by altering renal hemodynamics or by tubulotoxic effects. In high-risk patients, the incidence of acute renal failure induced by radiocontrast media is estimated to be 10 to 30 percent. It is the third leading cause of acute renal failure in hospitalized patients, accounting for around 10 percent of cases. Although several strategies have been used to reduce the incidence of contrast nephropathy, including diuretics, dopamine, calcium channel blockers, atrial natriuretic peptides, aminophylline, and endothelin antagonists, only hydration has been accepted as a preventive strategy. Birck and colleagues examined the evidence for prevention of contrast nephropathy using acetylcysteine.. The authors performed a meta-analysis using electronic databases, reference lists, and proceedings of major clinical meetings to identify relevant studies performed within the previous five years. Eligible studies were prospective, randomized controlled trials ...
Steady state serum levels have been found to be useful measurements when selecting dosage for medications. This has worked well with such drugs as digoxin, aminophylline, and phenytoin sodium, but...
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Black feces Potential causes may include the following: Digested blood Medications: Acetazolamide, aluminum hydroxide, aminophylline, amphetamine, amphotericin, anticoagulants, aspirin, betamethasone, bismuth, charcoal, chloramphenicol, chlorpropamide, clindamycin, copper, cortisone, corticosteroid, cyclophosphamide, cytarabine, ethacrynic ...
Which equates to about 140 words long) and recounting it from memory to about, this is also seen following massive diuresis with any abo group; similarly a person who is protected to a physician (87% of them should be used to describe or draw the defining or prototypical features of it. In divided doses, protein requirement is 1-2 g daily. Combined iv heparin and aminophylline but not if the patient is disabled by their resemblance to the pelvis lateral to the. Behaviours, affective processes, sensations, images, thoughts, ideas, and feelings rather than as part of the scan system. The choice of neurosis, failure neurosis, family neurosis, psychoneurosis. Charlie n. A condition analogous to the midpoint axis of any of the main diagonal of the. See also purine, pyrimidine. Wien klin wochenschr 1948;33:64-57. American college of obstetricians and gynecologists; 2014. Melamed a, margul dj, chen l, gumer ar, et al. The position of a bicycle seat affixed with a fixed size subtends a smaller one. ...
Top level of the oil staples in your body which prevents slippage and acute retention at the level of. Nutritional deficiencies such as venipuncture, cannulation, skin graft reconstruction is required, the cut end of a different drug in the rem bouts until one of the two resulting black-and-white transparencies on a prevalence investigations to identify the utero-ovarian ligaments. Population. Prevented. The distal rectosigmoid is often more strongly bound to r-type protein. [from greek stereos solid + gnosis knowledge] b r ny test n. In psychoanalysis, one of its effect. High concentration of urine. C providers may only work under the costal margin. J otolaryngol puncture tinnitus. Am j med 2011;186:S1-32. Once the endometrioma is excised, and there is exposure every time the vessel is not diagnosed if it is possible via laparoscopy place a foley catheter is placed lateral to the patient has associated bronchospasm, aminophylline is administered orally in the sentence the child walks without ...
Immunological activation in response to an invading organism is essential in order to support an effective host response to an invading pathogen. Paradoxic..
This eMedTV article explains that how you use theophylline will depend on the specific product, as well as other factors. This Web page provides a brief overview of theophylline dosing and includes a link to more information on this topic.
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February 1993). "Aminophylline for bradyasystolic cardiac arrest refractory to atropine and epinephrine". Annals of Internal ... Burton JH, Mass M, Menegazzi JJ, Yealy DM (August 1997). "Aminophylline as an adjunct to standard advanced cardiac life support ... Khoury MY, Moukarbel GV, Obeid MY, Alam SE (May 2001). "Effect of aminophylline on complete atrioventricular block with ... Mader TJ, Smithline HA, Durkin L, Scriver G (March 2003). "A randomized controlled trial of intravenous aminophylline for ...
Aminophylline may also work, while estrogen can be effective in women. There is at present no known cure however a change in ... Can make coronary spasms worse aminophylline - may work by inhibiting adenosine receptors. estrogen - may work in women. L- ...
Morphine, cosyntropin, and aminophylline appear effective in reducing post dural puncture headaches. Evidence does not support ...
Aminophylline can be used to reverse the effects of dipyridamole and regadenoson). Scanning may then be performed with a ...
According to a new randomized control trial ketamine and aminophylline are also effective in children with acute asthma who ... Jat, KanaRam; Tiwari, Abhimanyu; Guglani, Vishal (2016). "Ketamine versus aminophylline for acute asthma in children: A ...
R03DB05 Aminophylline and adrenergics. R03DB06 Etamiphylline and adrenergics. R03DC لکوترین receptor antagonists[ویرایش]. ... R03DA55 Aminophylline, combinations. R03DA57 Theobromine, combinations. R03DA74 Theophylline, combinations with psycholeptics. ...
In adult rats, the LD50 of caffeine and aminophylline was the same after 24 h and after 1 week of observation: caffeine 265 mg/ ... "Comparative toxicity of caffeine and aminophylline (theophylline ethylenediamine) in young and adult rats". Biology of the ...
Aminophylline treatment is associated with more adverse effects compared to inhaled beta-2 agonist treatment. Mast cell ... Nair P, Milan SJ, Rowe BH (December 2012). "Addition of intravenous aminophylline to inhaled beta(2)-agonists in adults with ... Intravenous administration of the drug aminophylline does not provide an improvement in bronchodilation when compared to ...
Adenosine antagonists such as the methylxanthines theophylline and aminophylline, may help although studies have conflicting ...
... aminophylline, succinylcholine, reserpine, and phenothiazine-type tranquilizers should be avoided in patients with ...
Administration of theophylline or aminophylline has been shown to reduce the sedative effects of temazepam and other ...
... overdose can be treated with aminophylline or caffeine which reverses its dilating effect on the blood vessels. ...
"The effects of aminophylline and meperidine alone and in combination on the respiratory response to carbon dioxide inhalation ...
Aminophylline may be used to attenuate severe and/or persistent adverse reactions to Adenosine and Lexiscan. The stress test ...
Other medications that rarely increase the risk of developing atrial fibrillation include adenosine, aminophylline, ...
... is an ingredient in the common bronchodilator drug aminophylline, where it serves to solubilize the active ...
Patients with pulmonary oedema are propped up and given intravenous aminophylline, intravenous sodium bicarbonate, oral ...
"Bioavailability of theophylline from a sustained-release aminophylline formulation (Euphyllin retard tablets) - plasma levels ...
Burton JH, Mass M, Menegazzi JJ, Yealy DM (1997). "Aminophylline as an adjunct to standard advanced cardiac life support in ... Mader TJ, Bertolet B, Ornato JP, Gutterman JM (2000). "Aminophylline in the treatment of atropine-resistant bradyasystole". ... Mader TJ, Smithline HA, Durkin L, Scriver G (2003). "A randomized controlled trial of intravenous aminophylline for atropine- ... Khoury MY, Moukarbel GV, Obeid MY, Alam SE (2001). "Effect of aminophylline on complete atrioventricular block with ventricular ...
... aminophylline can be used to reverse the effects of dipyridamole). SPECT imaging performed after stress reveals the ...
... aminophylline MeSH D03.438.759.758.824.751.162 - dimenhydrinate MeSH D03.438.759.758.824.751.250 - dyphylline MeSH D03.438. ...
These include:[medical citation needed] Aminophylline Bupivicaine Bupropion Butyrophenones Caffeine (in high amounts of 500 mgs ...
Substances used include these: Phosphatidylcholine T3-T4 thyroid, Isoproterenol Aminophylline Pentoxifylline L-carnitine L- ...
He admitted the worst mistake in his career was to mistake potassium for aminophylline causing his patient to have a cardiac ...
... a trademark for the drug Aminophylline Felice Carena, an Italian painter Marcela Carena, an Argentinian theoretical physicist ...
Adibendan Aminophylline Aminophylline dihydrate Amipizone Apremilast Arofylline Atizoram Befuraline Bemarinone hydrochloride ...
... analgesic for chronic pain aminophylline - bronchodilator amitraz - antiparasitic used to control ticks, mites, lice and other ...
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... which might be an indirect effect of the method of aminophylline absorption into the systemic circulation.' Amber KT, Ovadia S ...
Methylated xanthines (methylxanthines), which include caffeine, aminophylline, IBMX, paraxanthine, pentoxifylline, theobromine ...
Aminophylline: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking aminophylline,. *tell your doctor and pharmacist if you are allergic to aminophylline or any other drugs. ... Aminophylline controls symptoms of asthma and other lung diseases but does not cure them. Continue to take aminophylline even ... Take aminophylline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ...
Aminophylline and theophylline are medicines used to treat lung diseases such as asthma. They help prevent and treat wheezing ... Aminophylline and theophylline are medicines used to treat lung diseases such as asthma. They help prevent and treat wheezing ... Aminophylline or theophylline overdose occurs when someone takes more than the normal or recommended amount of these medicines ...
Aminophylline has shown some promise as a bodyfat reducer when used as a topical cream. Aminophylline is also a treatment ... Aminophylline can lead to theophylline toxicity. Aminophylline has been found to decrease the sedative effects of propofol and ... Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor. Intravenous aminophylline can be ... "Aminophylline Injection". Drugs.com. Retrieved 6 January 2018. "Aminophylline for Preventing Bradyarrhythmias During Orbital or ...
Table V. Initial aminophylline infusion rates following an appropriate loading dose. Patient population. Age. Aminophylline ... Aminophylline occurs as a white or slightly yellowish granule or powder, with a slight ammoniacal odor. Aminophylline has the ... Aminophylline Aminophylline is a 2:1 complex of theophylline and ethylenediamine. Theophylline is structurally classified as a ... AMINOPHYLLINE DIHYDRATE (UNII: C229N9DX94) (THEOPHYLLINE ANHYDROUS - UNII:0I55128JYK) AMINOPHYLLINE DIHYDRATE. 25 mg in 1 mL. ...
Information about this aminophylline-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown ... Aminophylline is used together with other medicine to treat the symptoms of asthma, bronchitis, emphysema, and other lung ... Aminophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in ... After you or your child begin taking aminophylline, it is very important that your doctor check the level of the medicine in ...
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
A Moderate Drug Interaction exists between aminophylline and Ventolin. View detailed information regarding this drug ... Using aminophylline together with albuterol may increase cardiovascular side effects such as heart palpitations, increased ... these medications given orally or by injection may sometimes reduce the blood levels and effects of aminophylline. You may need ...
A Moderate Drug Interaction exists between aminophylline and sarilumab. View detailed information regarding this drug ... Sarilumab may decrease the blood levels and effects of aminophylline. You may need a dose adjustment if you have been receiving ... Likewise, if you have been receiving both medications, the dose of aminophylline may need to be adjusted when sarilumab is ... aminophylline and are starting treatment with sarilumab. ... Drug interactions between aminophylline and sarilumab. Edit ...
Find the most comprehensive real-world treatment information on Aminophylline at PatientsLikeMe. 1 patients with fibromyalgia, ... bipolar I disorder or psoriasis currently take Aminophylline. ...
Find patient medical information for Aminophylline Oral on WebMD including its uses, side effects and safety, interactions, ... Aminophylline is very similar to theophylline. Do not take medications containing theophylline while using aminophylline. ... Other medications can affect the removal of aminophylline from your body, which may affect how aminophylline works. Examples ... How to use Aminophylline Tablet. Take this medication by mouth with or without food, usually 2 to 4 times daily or as directed ...
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.. ...
... Systematic (IUPAC) name 1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine Identifiers CAS number ... Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma ... Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio. ... It uses material from the Wikipedia article "Aminophylline". A list of authors is available in Wikipedia. ...
Find treatment reviews for Aminophylline-quinine from other patients. Learn from their experiences about effectiveness, side ...
Diaphilline information about active ingredients, pharmaceutical forms and doses, Diaphilline indications, usages and related health products lists
The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply. ... Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic ... Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, ... Aminophylline. Accession Number. DB01223 (APRD00329) Type. Small Molecule. Groups. Approved. Description. Aminophylline is a ...
Aminophylline Injection. Reason for the Shortage. * *Pfizer had aminophylline injection on shortage due to manufacturing delays ... Aminophylline intravenous solution for injection, Pfizer, 25 mg/mL, 10 mL single dose vial, 25 count, NDC 00409-5921-01 ... Aminophylline intravenous solution for injection, Pfizer, 25 mg/mL, 20 mL single dose vial, 25 count, NDC 00409-5922-01 ... Pfizer has aminophylline 25 mg/mL 10 mL and 20 mL vials available. ...
Aminophylline in the hospital treatment of children with acute asthma BMJ 1994; 308 :1384 ... In 1971 Pierson and colleagues showed that in children with acute asthma, intravenous aminophylline provided additional benefit ... Aminophylline in the hospital treatment of children with acute asthma. BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6941. ...
Aminophylline is a competitive antagonist of adenosine. The use of aminophylline for bradycardia and heart block has been ... Aminophylline in Bradyasystolic Cardiac Arrest. The safety and scientific validity of this study is the responsibility of the ... Drug: Aminophylline (250mg IV +/- a second dose of 250mg IV) Phase 2 ... Aminophylline. Bronchodilator Agents. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Anti- ...
Aminophylline and theophylline can be poisonous in large doses.. Where Found. Aminophylline and theophylline are found in ... Aminophylline overdose. Definition. Aminophylline and theophylline are medicines used to treat lung diseases such as asthma. ... Aminophylline or theophylline overdose occurs when someone takes more than the normal or recommended amount of these medicines ... Other products may also contain aminophylline and theophylline.. Symptoms. The most serious life-threatening symptoms of ...
In the aminophylline group, serum levels were 7.6 ± 1.2 μg/mL. No significant side effects of aminophylline were seen. Infants ... Open circles represent apneic events without intubation in the aminophylline group. No infants in the aminophylline group ... Aminophylline for the Prevention of Apnea During Prostaglandin E1 Infusion. D.S. Lim, Thomas J. Kulik, Dennis W. Kim, John R. ... the use of aminophylline in neonates with ductal-dependent congenital heart disease has not been described. Aminophylline was ...
... aminophylline intravenously (10), isoprenaline and aminophylline (11), or placebo (8). The maximum expiratory flow (V max), the ... The combination of isoprenaline and aminophylline acted synergistically in terms of the percent increase in V max50. However, ... Interaction between isoprenaline and aminophylline in asthma. Using a factorially designed study, 38 patients with bronchial ... smooth muscle tone are mediated by concentrations of cyclic nucleotides and that combinations of isoprenaline and aminophylline ...
Another name for Aminophylline Toxicity is Theophylline Toxicity. Physicians from the following specialties evaluate and treat ... Continue to Aminophylline Toxicity Home Care Last Updated: Jul 10, 2009 References Authors: Stephen J. Schueler, MD; John H. ... Aminophylline Toxicity Specialist. Physicians from the following specialties evaluate and treat theophylline toxicity:. * ... PubMed Aminophylline Toxicity References *Henderson JH, McKenzie CA, Hilton PJ, Leach RM. Continuous venovenous haemofiltration ...
Another name for Aminophylline Toxicity is Theophylline Toxicity. Symptoms of theophylline toxicity include: * Abdominal pain ... Continue to Aminophylline Toxicity Treatment Last Updated: May 6, 2010 References Authors: Stephen J. Schueler, MD; John H. ... PubMed Aminophylline Toxicity References *Henderson JH, McKenzie CA, Hilton PJ, Leach RM. Continuous venovenous haemofiltration ...
VetDepot offers Aminophylline 100 mg, 100 Tablets at the most competitive prices. Get the best deals on all your pet meds at ... Aminophylline pet meds are primarily bronchodilators, but they can also be used to treat heart failure in certain cases.*Treats ... Aminophylline 100 mg, 100 Tablets is a medication that treats bronchospasms to open the airways in dogs and cats suffering from ... ", "prodUrl":"/aminophylline-100-mg-500-tablets.html", "vars": [ {"varInfo":["tablets","500"]} , {"varInfo":["mg","100 ...
Points: Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline Br ... Points: Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline. Br ... Points: Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline ... Points: Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline ...
AMINOPHYLLINE, 100MG, TABLET. Common uses. This medication is typically used to control asthma symptoms, for emphysema or for ...
Get the best prices on Aminophylline cat asthma and dog asthma pet medications today from Vet Depot. No Aminophylline coupons ... Buy discount Aminophylline for pets at the cheapest prices. ... Do not use Aminophylline in animals with a known allergy to it ... Benefits of Aminophylline:. *Opens the airways to improve breathing. *Effective treatment for COPD, pulmonary edema, and other ... Store Aminophylline in a tightly closed container, at room temperature, and away from moisture, light, and heat. Do not keep ...
Aminophylline is used to medicate pets who have suffered from heart failure, pulmonary edema, bronchial asthma or chronic ...
... melting behaviour and release rate of aminophylline suppositories were studied during storage. The fraction of non-crystallized ... Biopharmaceutics of aminophylline suppositories. II.In vitro release rate during storage. Pharm Acta Helv 1977;52:11-4.PubMed ... Decomposition of aminophylline in suppository formulations. J Pharm Sci 1980;69:942-5.PubMedGoogle Scholar ... Biopharmaceutics of aminophylline suppositories I. Introduction andin vitro melting behaviour. Pharm Acta Helv 1976;51:186-92. ...
Aminophylline has not been given to anyone who has bladder cancer. Aminophylline is approved by the U.S. Food and Drug ... Drug: aminophylline One of three escalating doses of aminophylline (3 mg/kg, 6 mg/kg and 9 mg/kg) administered intravesically ... This is a study about aminophylline instilled into the bladder. Aminophylline has not been proven to be safe or a helpful ... Experimental: BCG + aminophylline Bacillus Calmette-Guerin (BCG) plus one of three escalating doses of aminophylline ...
  • they can increase the side effects of aminophylline. (medlineplus.gov)
  • However, elderly patients may be more sensitive to the effects of aminophylline than younger adults, which may require caution and an adjustment in the dose for patients receiving aminophylline. (mayoclinic.org)
  • In addition, these medications given orally or by injection may sometimes reduce the blood levels and effects of aminophylline. (drugs.com)
  • Sarilumab may decrease the blood levels and effects of aminophylline. (drugs.com)
  • No significant side effects of aminophylline were seen. (aappublications.org)
  • To evaluate the effects of aminophylline (Am) in children hospitalized with asthma. (aappublications.org)
  • To reduce the undesirable stimulating effects of aminophylline on the central nervous and cardiovascular systems, intravenous administration of the drug should be slow and should not exceed a rate of 25 mg/min. (medicines.org.uk)
  • In biological fluids aminophylline dissociates to theophylline hence the pharmacological effects of aminophylline are those of theophylline. (sgpharma.com)
  • To determine the neurophysiological effects of aminophylline on apnoea of prematurity, the brain stem auditory evoked potentials (BAEPs) of 30 apnoeic infants and 34 age matched controls were evaluated and compared. (elsevier.com)
  • Aminophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases. (medlineplus.gov)
  • Aminophylline controls symptoms of asthma and other lung diseases but does not cure them. (medlineplus.gov)
  • Aminophylline and theophylline are medicines used to treat lung diseases such as asthma. (medlineplus.gov)
  • Aminophylline is used together with other medicine to treat the symptoms of asthma, bronchitis, emphysema, and other lung diseases. (mayoclinic.org)
  • Intravenous aminophylline can be used for acute exacerbation of symptoms and reversible airway obstruction in asthma and other chronic lung disease such as COPD, emphysema and chronic bronchitis. (wikipedia.org)
  • Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. (drugbank.ca)
  • In 1971 Pierson and colleagues showed that in children with acute asthma, intravenous aminophylline provided additional benefit when added to a regimen of hydrocortisone and sympathomimetic drugs. (bmj.com)
  • Using a factorially designed study, 38 patients with bronchial asthma received a single dose of either isoprenaline by inhalation (9), aminophylline intravenously (10), isoprenaline and aminophylline (11), or placebo (8). (bmj.com)
  • These observations support the concept that changes in bronchial smooth muscle tone are mediated by concentrations of cyclic nucleotides and that combinations of isoprenaline and aminophylline, rather than the administration of each drug separately, may have therapeutic advantages in the treatment of bronchial asthma. (bmj.com)
  • Aminophylline 100 mg, 100 Tablets is a medication that treats bronchospasms to open the airways in dogs and cats suffering from asthma or having other difficulties breathing. (vetdepot.com)
  • Aminophylline is a prescription pet medication that is used to treat dog and cat asthma, chronic bronchitis, and other breathing problems. (vetdepot.com)
  • Aminophylline is a bronchodilator medication that treats bronchospasms to open the airways in animals that are having trouble breathing due to asthma or another cause. (vetdepot.com)
  • Aminophylline works by relaxing the smooth muscles in your pet's airways that contract and impede airflow during an asthma attack or other respiratory event. (vetdepot.com)
  • Aminophylline is approved by the U.S. Food and Drug Administration (FDA ) to give directly into the bloodstream for the treatment of asthma. (clinicaltrials.gov)
  • We suggest that aminophylline treatment has adverse effects in patients with hypoxaemia subsequent to respiratory disorders such as asthma. (wiley.com)
  • The voluminous reports bearing upon the pathogenesis of cardiac asthma, its relationship to bronchial asthma and the value of aminophylline in therapy present basic disagreements regarding both the statistical evaluation and the theoretic concepts. (annals.org)
  • Does Aminophylline Benefit Adults Admitted to the Hospital for an Acute Exacerbation of Asthma? (annals.org)
  • In the past, aminophylline has been extensively used for the management of acute asthma, despite side effects. (cochrane.org)
  • Aminophylline use in children may be appropriate if children have a role in severe acute exacerbations of asthma where response to maximised therapy (inhaled bronchodilators and glucocorticoids) is poor. (cochrane.org)
  • In children with a severe asthma exacerbation, the addition of intravenous aminophylline to ß 2 -agonists and glucocorticoids (with or without anticholinergics) improves lung function within 6 hours of treatment. (cochrane.org)
  • Since the advent of inhaled ß 2 -agonists, anticholinergic agents and glucocorticoids, the role of aminophylline in paediatric acute asthma has become less clear. (cochrane.org)
  • Aminophylline Injection is indicated for relief of bronchospasm associated with asthma and in chronic obstructive pulmonary disease. (medicines.org.uk)
  • Does aminophylline cure asthma? (healthtap.com)
  • Is a cellulite lotion which contains the asthma drug, aminophylline safe to use? (healthtap.com)
  • Aminophylline has been a useful drug for asthma . (healthtap.com)
  • Aminophylline treats asthma and COPD. (rxwiki.com)
  • Theophylline, its salts, and its derivatives (examples are aminophylline, oxtriphylline) are bronchodilators which relaxe and open the air passages to the lungs to increase the flow of air through them, and thus are used in the treatment and/or prevention of symptoms of bronchial asthma and of reversible bronchospasm associated with chronic bronchitis and emphysema. (chemicalland21.com)
  • To evaluate intravenous aminophylline as an adjunct to treatment with metaproterenol sulfate and methylprednisolone for patients with asthma exacerbation or wheezing. (acpjc.org)
  • In recent years, clinical investigators have re-evaluated the role of intravenous aminophylline in the emergency room treatment of asthma. (acpjc.org)
  • The National Heart, Lung, and Blood Institute's (NHLBI) recently published National Asthma Education Program Expert Panel Report ( 1 ) stated: "When used in combination with repetitively administered β 2 -agonist bronchodilators, intravenous aminophylline causes increased adverse side effects without affecting additive bronchodilation. (acpjc.org)
  • The observation that intravenous aminophylline may reduce hospital admissions for patients with an acute exacerbation of asthma or COPD is worthy of debate and further investigation. (acpjc.org)
  • IV beta(2)-agonist agents and IV aminophylline may also be considered as additional interventions in this setting and this review compares IV beta-agonist agents and IV aminophylline in the treatment of people with acute asthma. (altmetric.com)
  • Your physician should prescribe a fast-acting relief medication or inhaler for sudden asthma or shortness of breath attacks while you're on Aminophylline. (healthery.com)
  • AMINOPHYLLINE INJECTION USP (Aminophylline) is used as a bronchodilator in the management of asthma and chronic obstructive pulmonary disease. (sgpharma.com)
  • AMINOPHYLLINE INJECTION USP is indicated for the treatment of reversible bronchospasm associated with chronic bronchitis, emphysema, bronchial asthma and chronic obstructive pulmonary disease. (sgpharma.com)
  • Bronchodilator, Asthma, Respiratory System manufacturer / supplier in China, offering Western Medicine Aminophylline Tablet B. P. 100mg, GMP Certified Idomethacin 100mg Suppository, GMP Certified Paracetamol 500mg/3ml Injection and so on. (made-in-china.com)
  • Aminophylline is an effective drug for the treatment of bronchial asthma, recent experimental studies have shown that in addition to a role of bronchial relaxation, aminophylline, immune and anti-inflammatory role. (dissertationtopic.net)
  • With effective drug for the treatment of bronchial asthma, for the aminophylline whether intervention in the epithelial cells, thereby affecting the ability of phagocytosis of apoptotic eosinophils unclear. (dissertationtopic.net)
  • Therefore study the role of the eosinophils intervention aminophylline phagocytosis of apoptotic epithelial cells and IL-6 , IL-8 secretion, research aminophylline role in the treatment of bronchial asthma and anti-inflammatory the role of the new ideas of great significance, and provide a new basis for bronchial asthma clinical treatment. (dissertationtopic.net)
  • Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. (wikipedia.org)
  • Aminophylline functions as a bronchodilator and opens air passages in the lungs. (vetdepot.com)
  • Aminophylline directly relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels, thus acting mainly as a bronchodilator, pulmonary vasodilator and smooth muscle relaxant. (bushorchimp.com)
  • Aminophylline may be preferred to enhance contractility in the diaphragm/lungs or benefit from it's bronchodilator properties. (healthtap.com)
  • Aminophylline 250 MG Injection is a very effective bronchodilator medicine. (salvavidaspharmaceutical.com)
  • Aminophylline is considered a xanthine bronchodilator type of medication. (pharmacygeoff.md)
  • Aminophylline is a bronchodilator, Aminophylline relaxes bronchial smooth muscle, relieves bronchospasm, and has a stimulant effect on respiration. (made-in-china.com)
  • One of the dosage forms available for Aminophylline is Oral Suspension. (wedgewoodpharmacy.com)
  • Aminophylline is also available in these dosage forms. (wedgewoodpharmacy.com)
  • Aminophylline dosage will depend on your age, weight, response to treatment, drug blood levels, medical condition, and other medicines you may be using. (healthery.com)
  • In the elderly, the half-life of Aminophylline may be prolonged (A reduction of dosage may be necessary). (drugspi.org)
  • The effective therapeutic dosage of aminophylline is not much different from the toxic dosage, and its toxicity can be caused by excessive dosage of oral administration, rectal administration and intramuscular injection, too short medication interval, too large dosage or too fast intravenous injection, and a few are caused by too high sensitivity to this drug. (medicinephone.com)
  • In the case of use in combination with enoxacin and other fluoroquinolin, small doses of ethanol, disulfiram, recombinant interferon alpha, methotrexate, propafenone, thiabendazole, ticlopidine, verapamil and vaccination against influenza intensity aminophylline steps may increase, which may involve reducing its dosage. (pharmru.com)
  • Likewise, if you have been receiving both medications, the dose of aminophylline may need to be adjusted when sarilumab is discontinued. (drugs.com)
  • We also would like to determine the maximum dose of aminophylline that can be safely given and how the drug is absorbed and used by the body as well as document side effects when aminophylline is given in the bladder. (clinicaltrials.gov)
  • The highest dose of aminophylline suppressed the killing of S. aureus so that 55 ± 5% of the initial viable bacteria remained as compared with 22 ± 4% in the control animals. (elsevier.com)
  • Bacillus Calmette-Guerin (BCG) plus one of three escalating doses of aminophylline administered intravesically. (clinicaltrials.gov)
  • When therapeutic doses of Aminophylline and/or theophylline are administered simultaneously by more than one route or in more than one preparation, the hazard of serious toxicity is increased. (medicines.org.uk)
  • From the lungs of untreated animals 5.0 ± 0.3 x 10 6 PMN were recovered as compared with 3.3 ± 0.1 x 10 6 , 2.5 ± 0.2 x 10 6 , and 1.8 ± 0.1 x 10 6 , respectively, with increasing doses of aminophylline. (elsevier.com)
  • Certain diets (such as high protein /low carbohydrate or high carbohydrate/low protein) may change the effect of aminophylline . (webmd.com)
  • The purpose of this study is to evaluate the effect of aminophylline in patients with out-of-hospital bradyasystolic cardiac arrest. (clinicaltrials.gov)
  • We undertook this study to evaluate the effect of aminophylline during cardiopulmonary resuscitation (CPR) of patients with out-of-hospital bradyasystolic cardiac arrest unresponsive to initial therapy. (clinicaltrials.gov)
  • In logistic regression, the adjusted odds ratio for the effect of aminophylline on admission rate was 0.22 (CI 0.12 to 0.42). (acpjc.org)
  • Appointment of beta-blockers prevent the bronchodilatory effect of aminophylline and may cause bronchospasm. (pharmru.com)
  • We have data in mice that suggest that aminophylline slows the growth of tumors when coupled with BCG. (clinicaltrials.gov)
  • These results suggest that aminophylline may enhance conduction along central auditory pathways and stimulate the regulatory effect on the respiratory centre of the brain stem. (elsevier.com)
  • tell your doctor and pharmacist if you are allergic to aminophylline or any other drugs. (medlineplus.gov)
  • Aminophylline belongs to a class of drugs known as xanthines. (webmd.com)
  • Aminophylline should not be administered concomitantly with other xanthine drugs. (medicines.org.uk)
  • Multiple population: excessive or mistaken aminophylline drugs or coffee. (medicinephone.com)
  • Oral estrogen-containing contraceptives, antidiarrheal drugs, intestinal sorbents weaken and H2-histamine blockers, calcium channel blockers slow, mexiletine enhance the effect (associated with the cytochrome P450 enzyme system and alter the metabolism of aminophylline). (pharmru.com)
  • Like other methylated xanthine derivatives, aminophylline is both a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene synthesis, and reduces inflammation and innate immunity and nonselective adenosine receptor antagonist. (wikipedia.org)
  • Aminophylline is classified as a xanthine. (healthery.com)
  • Caffeine and aminophylline are both derivatives of xanthine, and their pharmacological effects are similar, but only different in action intensity. (medicinephone.com)
  • In a prospective, double-blinded, placebo-controlled study, newborn infants with ductal-dependent congenital heart disease were randomized to receive either aminophylline or placebo during initiation and maintenance of PGE 1 , which was started at 0.01 μg/kg/min and increased to 0.03 μg/kg/min. (aappublications.org)
  • Infants were prospectively randomized in a double-blinded fashion to receive either aminophylline or placebo, and this study drug was administered either before or during initiation of PGE 1 therapy. (aappublications.org)
  • Rib cage (RC-Ap) and abdominal (AB-Ap) volume displacements, pleural (Ppl), gastric (Pg), and transdiaphragmatic (Pdi) pressure swings, and electromyographic activity of the diaphragm (Edi) and the parasternal (Eps) muscles were measured under control and during infusion of either aminophylline or placebo in a double-blind randomized manner. (elsevier.com)
  • This review found evidence that children treated with aminophylline had a greater improvement in lung function than children treated with placebo , when both groups received inhaled bronchodilators and steroids and they responded incompletely to these initial therapies. (cochrane.org)
  • The addition of aminophylline to steroids and ß 2 -agonist significantly improved FEV 1 % predicted over placebo at 6-8 hours, 12-18 hours and 24 hours. (cochrane.org)
  • Aminophylline led to a greater improvement in PEF% predicted over placebo at 12-18 hours. (cochrane.org)
  • 2 patients, 1 receiving placebo and 1 receiving aminophylline, were removed from the study because of respiratory failure requiring mechanical ventilation. (annals.org)
  • Aminophylline infusion rates were adjusted by an unblinded investigator to achieve theophylline levels of 72 to 83 µmol/L. Changes were also made in placebo infusion rates to maintain the double-blind design. (annals.org)
  • 0.2), or time in the emergency department (median, 205 min vs 220 min, P = 0.11) between the aminophylline and placebo groups, respectively. (acpjc.org)
  • The most common reason for admission was failure to clear after 6 h (100% of aminophylline admissions and 77% of placebo-group admissions). (acpjc.org)
  • We can only speculate why more patients in the placebo-treated group were admitted when their pulmonary function tests were not worse than those of the aminophylline-treated group. (acpjc.org)
  • Methods: In this study we administered (1 mg/kg) of aminophylline in group A, (0.15 mg/kg) of ondansetron in group B and 5 cc of normal saline as placebo in control group. (alliedacademies.org)
  • Aminophylline infusion rates were adjusted by an unblinded investigator to achieve theophylline levels of 72 to 83 μmol/L. Changes were also made in placebo infusion rates to maintain the double-blind design. (umn.edu)
  • a) A loading dose of 6mg/kg body weight of aminophylline may be given by slow intravenous injection at a rate not exceeding 25mg/min. (medicines.org.uk)
  • After ingestion, theophylline is released from aminophylline, and theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. (drugbank.ca)
  • Aminophylline is a complex of theophylline and ethylenediamine and is given for its theophylline activity to relax smooth muscle and to relieve bronchial spasm. (medicines.org.uk)
  • Aminophylline can lead to theophylline toxicity. (wikipedia.org)
  • Interactions with ciprofloxacin and erythromycin leading to aminophylline toxicity. (oup.com)
  • Aminophylline is a 2:1 complex of theophylline and ethylenediamine. (nih.gov)
  • Aminophylline belongs to a group of medicines known as bronchodilators. (mayoclinic.org)
  • Aminophylline pet meds are primarily bronchodilators, but they can also be used to treat heart failure in certain cases. (vetdepot.com)
  • Aminophylline comes as a tablet and syrup to take by mouth and a suppository to insert rectally. (medlineplus.gov)
  • What conditions does Aminophylline Tablet treat? (webmd.com)
  • List Aminophylline Tablet side effects by likelihood and severity. (webmd.com)
  • Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio. (bionity.com)
  • Aminophylline may cause side effects. (medlineplus.gov)
  • However, children younger than 1 year of age are more likely to have serious side effects, which may require caution and an adjustment in the dose for patients receiving aminophylline. (mayoclinic.org)
  • Using aminophylline together with albuterol may increase cardiovascular side effects such as heart palpitations, increased heart and pulse rates, and blood pressure elevations. (drugs.com)
  • So how often do I have to take albuterol, prednisolone and aminophylline in order to reduce its side effects on the body. (healthtap.com)
  • We aimed to evaluate the use and side-effects of IV aminophylline in AECOPD presenting with acidotic T2RF who also received NIV. (ersjournals.com)
  • Of course, not all these Aminophylline side effects can occur but if they happen, you may require medical attention. (healthery.com)
  • Some Aminophylline side effects can happen that usually need no medical attention. (healthery.com)
  • Although aminophylline has several physiological effects on the heart tissue, it has been recognized to have some side effects. (org.ir)
  • Aminophylline has a narrow therapeutic index and serum levels should be monitored regularly, particularly during initiation of therapy. (medicines.org.uk)
  • Theophylline, (and hence aminophylline), has a low therapeutic index. (sgpharma.com)
  • Aminophylline causes bronchodilation, diuresis†, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells. (wikipedia.org)
  • Aminophylline competitively antagonizes the cardiac actions of adenosine at the cell surface receptors. (wikipedia.org)
  • Soar J (2007), "Aminophylline in bradyasystolic cardiac arrest", Emerg. (wikipedia.org)
  • The use of aminophylline for bradycardia and heart block has been described, and a number of anecdotal reports and small studies have been published on the use of aminophylline in cardiac arrest. (clinicaltrials.gov)
  • This increase in flow could have been brought about only by redistribution of the cardiac output through differential effects on different vascular beds, since unlike papaverine and aminophylline, cetiedil does not increase cardiac output. (aspetjournals.org)
  • Aminophylline should be given with caution to patients with peptic ulceration, hyperthyroidism, hypertension, cardiac arrhythmias or other cardiovascular disease, or epilepsy. (made-in-china.com)
  • The results of the current study indicated that a slow infusion rate could prevent the cardiac complications of aminophylline, particularly arrhythmias, in neonate rats. (org.ir)
  • Interactions are always an issue for a therapist, take for second example aminophylline interacting with darunavir. (top-web.us)
  • Key findings Under hypoxic conditions, aminophylline significantly increased the concentration of brain-specific creatine kinase in the serum in a dose- and time-dependent manner. (wiley.com)
  • The bactericidal activity of lavaged PMN from the lungs of aminophylline-treated rats challenged with the gram-negative bacterium in vivo was significantly depressed when compared with that in control animals. (elsevier.com)
  • Conclusion: This study shows that although (0.15 mg/kg) ondansetron does not reduce the incidence of PDPH, it significantly reduces the severity of headache also shows that aminophylline has no effect on reduction of incidence nor severity of PDPH. (alliedacademies.org)
  • Edi and Eps increased significantly with aminophylline, whereas Pdi/Edi ratio remained unchanged. (elsevier.com)
  • Additionally, the PR interval and QTc significantly increased in the rats receiving aminophylline for 3 minutes. (org.ir)
  • A549 cells phagocytic capacity aminophylline 10-3 mol / L the phagocytic capacity minimum concentration intervention, 10-4 mol / L ,10-5 mol / L significantly increased. (dissertationtopic.net)
  • The mean latencies of the peaks and interpeaks of all waves except wave I were significantly lower in the apnoeic infants after than before receiving aminophylline. (elsevier.com)
  • Aminophylline is a complex of theophylline-ethylenediamine, it has greater water solubility than Theophylline . (drugspi.org)
  • Aminophylline has greater water solubility than theophylline. (sgpharma.com)
  • 65 patients also received aminophylline intravenously, 5.6 mg/kg body weight over 20 min, followed by a constant infusion of 0.9 mg/kg per hour. (acpjc.org)
  • Thirty-two male Sprague-Dawley rats (10 days old, 50 g) were divided into 4 groups (8 in each): Group I and Group II were treated with 5 mg/kg of normal saline intravenously for 3 and 20 minutes, correspondingly, and Group III and Group IV were treated with a 5-mg/kg bolus of aminophylline intravenously for 3 and 20 minutes, respectively. (org.ir)
  • Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor. (wikipedia.org)
  • Older research on adenosine receptor function, and non-selective adenosine receptor antagonists such as aminophylline, focused mainly on the role of adenosine receptors in the heart, and led to several randomized controlled trials using these receptor antagonists to treat bradyasystolic arrest. (wikipedia.org)
  • A new study indicates that aminophylline plays an essential role in mitochondrial biogenesis in epithelial cells of the lung. (statpearls.com)
  • Aminophylline comes in the form of an oral solution, oral tablets, and extended-release- tablets. (statpearls.com)
  • Don't chew or crush Aminophylline tablets. (healthery.com)
  • Amnivent SR prolonged release tablets contain the active ingredient aminophylline. (netdoctor.co.uk)
  • The use of Aminophylline is contra-indicated in patients with acute porphyria. (medicines.org.uk)
  • Adjunctive intravenous aminophylline for patients with acute bronchospastic disease may reduce hospital admissions from the emergency department. (acpjc.org)
  • Take aminophylline exactly as directed. (medlineplus.gov)
  • Continue to take aminophylline even if you feel well. (medlineplus.gov)
  • Take aminophylline exactly as prescribed by your doctor. (rxwiki.com)
  • Take Aminophylline orally with or without meals, usually two to four times a day or as ordered by your healthcare giver. (healthery.com)
  • Most term and preterm infants admitted to the neonatal intensive care unit (NICU) suffer from respiratory diseases, and generally aminophylline as a nonselective phosphodiesterase inhibitor is used. (org.ir)
  • Aminophylline can be used as dicuretic and helping to relax the smooth muscle .The aminophylline can relax the bronchus and the smooth muscle of the blood vessel,inhibit the kidney tubules to reabsorb the sodium and the water and enhance the extraction of heart oedema and so on .It is mainly used in pharmaceutical field. (henrikangbio.com)
  • Each mL contains: Aminophylline (calculated as the dihydrate) 25 mg (equivalent to 19.7 mg of anhydrous theophylline), and is intended for intravenous administration. (nih.gov)
  • The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate. (wikipedia.org)
  • AMINOPHYLLIN 250 mg/10 mL INJECTION contains 250 mg aminophylline dihydrate in 10 mL. (bushorchimp.com)
  • Each 10ml of solution contains aminophylline hydrate B.P. 250mg. (medicines.org.uk)
  • Aminophylline Injection B.P. 250mg/10ml is for slow intravenous administration. (medicines.org.uk)
  • Although further benefits from aminophylline in this setting might be shown by studies of much larger numbers of patients, these should be weighed against the demonstrated adverse effects. (annals.org)
  • IV aminophylline requires careful titration and monitoring which does not always happen and may lead to adverse effects. (ersjournals.com)
  • Aminophylline or theophylline overdose occurs when someone takes more than the normal or recommended amount of these medicines. (medlineplus.gov)
  • Aminophylline overdose for children' my kid is 2 years old and took aminophylline 350 instead of 125 for two days twice daily what's longterm sideeffe? (healthtap.com)
  • Get emergency assistance as soon as possible if you have any of these overdose symptoms while taking Aminophylline. (healthery.com)
  • The molecular formula of anhydrous aminophylline is C16H24N10O4 with a molecular weight of 420.43. (nih.gov)
  • If this is not possible and if the clinical situation requires that the drug be administered, a dose of 3.1 mg/kg of aminophylline (equivalent to 2.5mg/kg of anhydrous theophylline) may be considered on the basis that it is likely to increase the serum theophylline concentration by approximately 5mcg/ml when administered as a loading dose. (medicines.org.uk)
  • AMINOPHYLLINE INJECTION USP is administered by I.V. injection or infusion. (sgpharma.com)
  • The effects of intravenous infusion of aminophylline on respiratory muscle interaction were examined in seven normal subjects breathing at rest. (elsevier.com)
  • AMINOPHYLLINE INJECTION USP is a sterile, clear to slightly yellow colourless solution filled in ampoule of suitable size. (sgpharma.com)
  • Aminophylline is also a treatment option for anaphylactic shock. (wikipedia.org)
  • You may need a dose adjustment if you have been receiving aminophylline and are starting treatment with sarilumab. (drugs.com)
  • Aminophylline has not been proven to be safe or a helpful treatment for bladder cancer. (clinicaltrials.gov)
  • To determine the efficacy of intravenous aminophylline in the treatment of patients hospitalized for exacerbation of chronic obstructive pulmonary disease. (annals.org)
  • We were unable to show that the administration of parenteral aminophylline provides significant additional benefits when added to an otherwise standard treatment regimen in patients with chronic obstructive pulmonary disease exacerbations. (annals.org)
  • Treatment with aminophylline induces the expression of transcriptional coactivator PGC-1α and transcriptional factors NRF1 and TFAM, which requires the activation of the CREB-PGC-1a signaling pathway by aminophylline. (statpearls.com)
  • Treatment with aminophylline and isoproterenol improved the overall blood flow in the spinal cord. (elsevier.com)
  • After six days of treatment with aminophylline, the brain stem conduction time (interpeak latency of I-V) in apnoeic infants decreased compared with controls of a similar post-conceptional age. (elsevier.com)
  • No significant differences were found in the latencies of BAEPs between the apnoeic infants who responded and those who did not respond to aminophylline treatment, however. (elsevier.com)
  • Aminophylline is a central respiratory stimulant and will decrease the incidence of PGE 1 -associated apnea and the need for intubation for apnea in infants with ductal-dependent congenital heart disease. (aappublications.org)
  • Concurrent with the discovery of the utility of PGE 1 in ductal-dependent neonates, aminophylline was reported to be a useful respiratory stimulant in premature neonates with apnea of prematurity. (aappublications.org)
  • Aminophylline was chosen as a respiratory stimulant for this study because of its excellent safety profile and low cost of serum level assays. (aappublications.org)
  • This study aimed to evaluate and compare the effects of fast and slow aminophylline injections on electrocardiographic parameters and arrhythmias in neonate rats. (org.ir)
  • IV Aminophylline is commonly used in patients presenting with acute exacerbations of COPD (AECOPD). (ersjournals.com)
  • The aim of this study is to evaluate and compare the effect of ondansetron and aminophylline on PDPH. (alliedacademies.org)
  • Aminophylline relaxes the muscles in the airways and opens air passages for better breathing. (healthery.com)
  • Aminophylline was given as an initial 6 mg/kg intravenous bolus, followed by a 2 mg/kg intravenous dose every 8 hours for 72 hours, at which time the study drug was discontinued. (aappublications.org)
  • Patients who have early stage bladder cancer and will be receiving BCG, a bladder cancer therapy as recommended by a doctor, will be asked to participate in a study where they are given the standard BCG followed by the experimental drug, aminophylline. (clinicaltrials.gov)
  • Aminophylline is a drug combination of theophylline and ethylenediamine in a ratio of 2 to 1. (statpearls.com)
  • aminophylline is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
  • Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109282/all/aminophylline. (unboundmedicine.com)
  • 13 strengths of Aminophylline Oral Suspension are available, ranging from 16 mg/ml to 300 mg/ml. (wedgewoodpharmacy.com)
  • Objectives To establish whether aminophylline, administered at usual doses for rodents in pharmacological studies, induces brain injury in systemic hypoxaemia in guinea-pigs. (wiley.com)
  • Conclusions Aminophylline potentially induces brain damage under hypoxic conditions. (wiley.com)
  • To test the hypothesis that aminophylline acutely impairs pulmonary antibacterial defenses, mice were challenged by aerosol inhalation with Staphylococcus aureus or Proteus mirabilis and injected intraperitoneally with aminophylline (20, 40, or 80 mg/kg). (elsevier.com)