Aminophenols: Phenols substituted in any position by an amino group.Neoprene: An oil-resistant synthetic rubber made by the polymerization of chloroprene.Aminobenzoates: Derivatives of BENZOIC ACID that contain one or more amino groups attached to the benzene ring structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobenzoate structure.Hydroxylamines: Organic compounds that contain the (-NH2OH) radical.Hydroxybenzoates: Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.Aniline CompoundsDioxygenases: Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.NitrophenolsPseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Pseudomonas putida: A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Burkholderia: A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.

Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates. (1/178)

1. UDP-glucuronosyltransferase activity towards 12 substrates has been assessed in rat liver during the perinatal period. 2. Between days 16 and 20 of gestation, enzyme activities towards the substrates 2-aminophenol, 2-aminobenzoate, 4-nitrophenol, 1-naphthol, 4-methylumbelliferone and 5-hydroxytryptamine (the 'late foetal' group) surge to reach adult values, while activities towards bilirubin, testosterone, beta-oestradiol, morphine, phenolphthalein, and chloramphenicol (the 'neonatal' group) remain negligible or at less than 10% of adult values. 3. By the second postnatal day, enzyme activities towards the neonatal group have attained, or approached adult values. 4. Dexamethasone precociously stimulates in 17-day foetal liver in utero transferase activities in the late foetal, but not the neonatal group. A similar inductive pattern is found for 15-day foetal liver in organ culture. 5. It is suggested that foetal glucocorticoids, whose synthesis markedly increases between days 16 and 20 of gestation, are responsibile for triggering the simultaneous surge of all the hepatic UDP-glucuronosyltransferase activities in the late foetal group. The neonatal group of activities apparently require a different or additional stimulus for their appearance. 6. The relationship of these two groups of transferase activities to other similar groups observed during induction by xenobiotics and enzyme purification is discussed.  (+info)

Potent and selective human beta(3)-adrenergic receptor antagonists. (2/178)

Although the functional presence of beta(3)-adrenergic receptors (beta(3)-AR) in rodents is well established, its significance in human adipose tissue has been controversial. One of the issues confounding the experimental data has been the lack of potent and selective human beta(3)-AR ligands analogous to the rodent-specific agonist BRL37344. Recently, we described a new class of aryloxypropanolamine beta(3)-AR agonists that potently and selectively activate lipolysis in rhesus isolated adipocytes and stimulate the metabolic rate in rhesus monkeys in vivo. In this article, we describe novel and selective beta(3)-AR antagonists with high affinity for the human receptor. L-748,328 and L-748,337 bind the human cloned beta(3)-AR expressed in Chinese hamster ovary (CHO) cells with an affinity of 3.7 +/- 1.4 and 4.0 +/- 0.4 nM, respectively. They display an affinity of 467 +/- 89 and 390 +/- 154 nM for the human beta(1)-AR. Their selectivity for human beta(3)-AR versus beta(2)-AR is greater than 20-fold (99 +/- 43 nM) and 45-fold (204 +/- 75 nM), respectively. These compounds are competitive antagonists capable of inhibiting the functional activation of agonists in a dose-dependent manner in cells expressing human cloned beta(3)-AR. Moreover, both L-748,328 and L-748,337 inhibit the lipolytic response elicited by the beta(3)-AR agonist L-742,791 in isolated nonhuman primate adipocytes. The aryloxypropanolamine benzenesulfonamide ligands illustrated here and elsewhere demonstrate high-affinity human beta(3)-AR binding. In addition, we describe specific 3'-phenoxy substitutions that transform these compounds from potent agonists into selective antagonists.  (+info)

Characterization of hydroxylaminobenzene mutase from pNBZ139 cloned from Pseudomonas pseudoalcaligenes JS45. A highly associated SDS-stable enzyme catalyzing an intramolecular transfer of hydroxy groups. (3/178)

Hydroxylaminobenzene mutase is the enzyme that converts intermediates formed during initial steps in the degradation of nitrobenzene to a novel ring-fission lower pathway in Pseudomonas pseudoalcaligenes JS45. The mutase catalyzes a rearrangement of hydroxylaminobenzene to 2-aminophenol. The mechanism of the reactions and the properties of the enzymes are unknown. In crude extracts, the hydroxylaminobenzene mutase was stable at SDS concentrations as high as 2%. A procedure including Hitrap-SP, Hitrap-Q and Cu(II)-chelating chromatography was used to partially purify the enzyme from an Escherichia coli clone. The partially purified enzyme was eluted in the void volume of a Superose-12 gel-filtration column even in the presence of 0.05% SDS in 25 mM Tris/HCl buffer, which indicated that it was highly associated. When the enzymatic conversion of hydroxylaminobenzene to 2-aminophenol was carried out in 18O-labeled water, the product did not contain 18O, as determined by GC-MS. The results indicate that the reaction proceeded by intramolecular transfer of the hydroxy group from the nitrogen to the C-2 position of the ring. The mechanism is clearly different from the intermolecular transfer of the hydroxy group in the non-enzymatic Bamberger rearrangement of hydroxylaminobenzene to 4-aminophenol and in the enzymatic hydroxymutation of chorismate to isochorismate.  (+info)

Artificial DNAs with metal-assisted base pairs. (4/178)

Two types of artificial beta-C-nucleosides, 2 and 3, were newly synthesized, which possess a metal chelating site (2-aminophenol and catechol, respectively) at the nucleobase moiety. These nucleosides are expected to form metal-assisted base pairs in oligonucleotides and thereby to control high-order structures and functions of DNAs.  (+info)

Biotransformation of hydroxylaminobenzene and aminophenol by Pseudomonas putida 2NP8 cells grown in the presence of 3-nitrophenol. (5/178)

Biotransformation products of hydroxylaminobenzene and aminophenol produced by 3-nitrophenol-grown cells of Pseudomonas putida 2NP8, a strain grown on 2- and 3-nitrophenol, were characterized. Ammonia, 2-aminophenol, 4-aminophenol, 4-benzoquinone, N-acetyl-4-aminophenol, N-acetyl-2-aminophenol, 2-aminophenoxazine-3-one, 4-hydroquinone, and catechol were produced from hydroxylaminobenzene. Ammonia, N-acetyl-2-aminophenol, and 2-aminophenoxazine-3-one were produced from 2-aminophenol. All of these metabolites were also found in the nitrobenzene transformation medium, and this demonstrated that they were metabolites of nitrobenzene transformation via hydroxylaminobenzene. Production of 2-aminophenoxazine-3-one indicated that oxidation of 2-aminophenol via imine occurred. Rapid release of ammonia from 2-aminophenol transformation indicated that hydrolysis of the imine intermediate was the dominant reaction. The low level of 2-aminophenoxazine-3-one indicated that formation of this compound was probably due to a spontaneous reaction accompanying oxidation of 2-aminophenol via imine. 4-Hydroquinone and catechol were reduction products of 2- and 4-benzoquinones. Based on these transformation products, we propose a new ammonia release pathway via oxidation of aminophenol to benzoquinone monoimine and subsequent hydrolysis for transformation of nitroaromatic compounds by 3-nitrophenol-grown cells of P. putida 2NP8. We propose a parallel mechanism for 3-nitrophenol degradation in P. putida 2NP8, in which all of the possible intermediates are postulated.  (+info)

Metabolism of para-aminophenol by rat hepatocytes. (6/178)

Autoxidation of para-aminophenol (PAP) has been proposed to account for the selective nephrotoxicity of this compound. However, other studies suggest that hepatic metabolites of PAP rather than the parent compound may be responsible for renal damage. These studies were designed to investigate PAP metabolism in isolated hepatocytes. We synthesized several proposed metabolites for analysis by HPLC/mass spectrometry and compared those results with HPLC/mass spectrometric analyses of metabolites found after incubating hepatocytes with PAP. Hepatocytes prepared from male Sprague-Dawley rats were incubated in Krebs-Henseleit buffer at 37 degrees C for 5 h with 2.3 mM PAP under an atmosphere of 5% CO2/95% O2. Aliquots were withdrawn at 0.1 h of incubation and then hourly through 5 h of incubation. Reactions were terminated by the addition of acetonitrile. Hepatocyte viability was unaltered with PAP present in the incubation medium. We found that hepatocytes converted PAP to two major metabolites (PAP-GSH conjugates and PAP-N-acetylcysteine conjugates) and several minor metabolites [PAP-O-glucuronide, acetaminophen (APAP), APAP-O-glucuronide, APAP-GSH conjugates, and 4-hydroxyformanilide]. Preincubating hepatoyctes with 1-aminobenzotriazole, an inhibitor of cytochromes P450, did not alter the pattern of PAP metabolism. In conclusion, we found that PAP was metabolized in hepatocytes predominantly to PAP-GSH conjugates and PAP-N-acetylcysteine conjugates in sufficient quantities to account for the nephrotoxicity of PAP.  (+info)

Stimulation of defective Gunn-rat liver uridine diphosphate glucuronyltransferase activity in vitro by alkyl ketones. (7/178)

Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones.  (+info)

Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. (8/178)

The purpose of this study was to evaluate the feasibility of metabonomics technology for developing a rapid-throughput toxicity screen using 2 known hepatotoxicants: carbon tetrachloride (CCl(4)) and alpha-naphthylisothiocyanate (ANIT) and 2 known nephrotoxicants: 2-bromoethylamine (BEA) and 4-aminophenol (PAP). In addition, the diuretic furosemide (FURO) was also studied. Single doses of CCl(4) (0.1 and 0.5 ml/kg), ANIT (10 and 100 mg/kg), BEA (15 and 150 mg/kg), PAP (15 and 150 mg/kg) and FURO (1 and 5 mg) were administered as single IP or oral doses to groups of 4 male Wistar rats/dose. Twenty-four-h urine samples were collected pretest, daily through Day 4, and on Day 10 (high dose CCl(4) and BEA only). Blood samples were taken on Days 1, 2, and 4 or 1, 4, and 10 for clinical chemistry assessment, and the appropriate target organ was examined microscopically. NMR spectra of urine were acquired and the data processed and subjected to principal component analyses (PCA). The results demonstrated that the metabonomic approach could readily distinguish the onset and reversal of toxicity with good agreement between clinical chemistry and PCA data. In at least 2 instances (ANIT and BEA), PCA analysis suggested effects at low doses, which were not as evident by clinical chemistry or microscopic analysis. Furosemide, which had no effect at the doses employed, did not produce any changes in PCA patterns. These data support the contention that the metabonomic approach represents a promising new technology for the development of a rapid throughput in vivo toxicity screen.  (+info)

*Aminophenol

... may refer to any of three isomeric chemical compounds: 2-Aminophenol 3-Aminophenol 4-Aminophenol They are ...

*3-Aminophenol

It is the meta isomer of 2-aminophenol and 4-aminophenol. 3-Aminophenol can be prepared by caustic fusion of 3- ... 3-Aminophenol is an organic compound with formula C6H4(NH2)(OH). It is an aromatic amine and aromatic alcohol. ... 3-Aminophenol at Sigma-Aldrich. Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book ... Locants 2, 3, and 4 are recommended, not o, m, and p. Mitchell, Stephen C.; Waring, Rosemary H. (2000). "Aminophenols". ...

*2-Aminophenol

... is an organic compound with the formula , C=6 , H=4 (OH)N, H=2 . Along with its isomer 4-aminophenol, it is an ... 2-Aminophenol (and its isomer, 4-aminophenol) is industrially synthesized by reducing the corresponding nitrophenol by hydrogen ... 2-Aminophenol has a variety of uses. As a reducing agent, it is marketed under the names of Atomal and Ortol to develop black- ... 2-Aminophenol is an intermediate in the synthesis of dyes. It is particularly useful in yielding metal-complex dyes when ...

*O-aminophenol oxidase

... (EC 1.10.3.4, isophenoxazine synthase, o-aminophenol:O2 oxidoreductase, 2-aminophenol:O2 oxidoreductase, ... O-aminophenol oxidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... Subba Rao, P.V.; Vaidyanathan, C.S. (1967). "Studies on the metabolism of o-aminophenol. Purification and properties of ... Suzuki, H.; Furusho, Y.; Higashi, T.; Ohnishi, Y.; Horinouchi, S. (2006). "A novel o-aminophenol oxidase responsible for ...

*Coordination polymer

Particularly useful are derivatives of aminophenol. Metal complex dyes using copper or chromium are commonly used for producing ...

*Nucleophilic aromatic substitution

In the Bamberger rearrangement N-phenylhydroxylamines rearrange to 4-aminophenols. The nucleophile is water. In the Sandmeyer ...

*2-Hydroxymuconate-6-semialdehyde dehydrogenase

strain 10d: A different modified meta-cleavage pathway for 2-aminophenols". Biosci. Biotechnol. Biochem. 70 (11): 2653-2661. ...

*Glycin

... can be synthesized by reacting p-aminophenol with chloracetic acid in a solvent. Other uses of glycin can be found in ... Glycin is related to 4-aminophenol and Metol. Compared to Metol, glycin has a carboxyl group attached to the methyl group of ... Glycin, or N-(4-hydroxyphenyl)glycine, is N-substituted p-aminophenol. It is a photographic developing agent used in classic ...

*Momme Andresen

He worked on formulations based on p-phenylenediamine and p-aminophenol, among other aromatic amines. He discovered a useful ... formulation based on p-aminophenol. On 27 January 1891, a German patent application describing and claiming it was filed. That ...

*Aniline

Hypochlorous acid gives 4-aminophenol and para-amino diphenylamine. Oxidation with persulfate affords a variety of polyanilines ...

*Bamberger rearrangement

O-protonation 3 can form the nitrenium ion 4, which can react with nucleophiles (H2O) to form the desired 4-aminophenol 5. ... Part 4. Rearrangement of Sterically Hindered Phenylhydroxylamines to 4-Aminophenols in Aqueous Sulphuric Acid Solution". ... which will rearrange to give 4-aminophenols. It is named for the German chemist Eugen Bamberger (1857-1932). N- ...

*Paracetamol

4-Aminophenol may be obtained by the amide hydrolysis of paracetamol. 4-Aminophenol prepared this way, and related to the ... The nitro group is then reduced to an amine, giving 4-aminophenol. Finally, the amine is acetylated with acetic anhydride. ... It has been suggested that contamination of paracetamol with 4-aminophenol, the substance von Mering synthesised it from, may ... This reaction is also used to determine paracetamol in urine samples: After hydrolysis with hydrochloric acid, 4-aminophenol ...

*4-Nitrophenol

It is reduced to 4-aminophenol, then acetylated with acetic anhydride. 4-Nitrophenol is used as the precursor for the ...

*Nitrophenol

The mononitrated phenols are often hydrogenated to the corresponding aminophenols that are also useful industrially. 2,4- ...

*Skin whitening

2012). "Kinetic characterisation of o-aminophenols and aromatic o-diamines as suicide substrates of tyrosinase". Biochim. ... 2-diamine and 2-aminophenol, and 2,3-dihydroxybenzoic acid itself, tetrahydrofolic acid, analogues of pyrimidine and rhodanine ...

*4-Aminosalicylic acid

With heat, aminosalicylic acid is decarboxylated to produce CO2 and 3-aminophenol. PAS has been shown to be a pro-drug and it ... Vetuschi, C.; Ragno, G.; Mazzeo, P. (1988). "Determination of p-aminosalicylic acid and m-aminophenol by derivative UV- ...

*AM404

Chemically, it is the amide formed from 4-aminophenol and arachidonic acid. AM404 was originally reported to be an endogenous ...

*David Lester (biochemist)

Finding that p-aminophenol conjugates were excreted, they refuted the earlier theories that the accumulation of this substance ... The role of p-aminophenol in the production of methemoglobinemia after acetanilid". Journal of Pharmacology and Experimental ...

*Antimicrobial polymer

3.0.CO;2-7. Jeong, J.-H.; Byoun, Y.-S. (2002). "Poly(styrene-alt-maleic anhydride)-4-aminophenol conjugate: synthesis and ...

*Superadditive developer

Examples of Agent 1 include: Phenidone, Dimezone S, Metol, p-aminophenol, glycin, Eikonogen. These agents have nitrogen atoms ...

*Resorcinol

... by the action of nitrous acid on 3-aminophenol or on 1,3-diaminobenzene. Many ortho- and para-compounds of the aromatic series ...

*Novaluron

First, 2-chloro-4-nitrophenol is converted into chloro-4-aminophenol through a reduction reaction. After this first step, an ...

*C6H7NO

The molecular formula C6H7NO may refer to: Aminophenols 2-Aminophenol 3-Aminophenol 4-Aminophenol Nicotinyl alcohol ...

*8-Hydroxyquinoline

It is usually prepared from quinoline-8-sulfonic acid and from Skraup synthesis from 2-aminophenol. 8-Hydroxyquinoline is a ...

*Staveley Coal and Iron Company

The only plant remaining now is a p-aminophenol plant that produces active ingredients for paracetamol production. The site ...
China 2 Aminophenol, China 2 Aminophenol Suppliers and Manufacturers Directory - Source a Large Selection of 2 Aminophenol Products at from China Alibaba.com
Nominated Substances: 2-Acetylamino-4-methylphenol, N-Acetyl-m-aminophenol, 5-(4-Aminobenzamido)-2,3-cresotic acid, 2-Amino-4-chloro-5-nitrophenol, 2-Amino-4-chloro-6-nitrophenol, 2-Amino-6-chloro-4-nitrophenol, 2-Amino-4-chlorophenol, 6-Amino-4-chloro-1-phenol-2-sulfonic acid, 5-Amino-o-cresol, 2-Amino-4,6-dichlorophenol, 2-Amino-4,6-dinitrophenol, 4-Amino-4-hydroxy-3-methyl-diphenylamine, 2-Amino-4-methylphenol, 3-Amino-4-methylphenol, 2-Amino-4-(methylsulfonyl)phenol, 2-Amino-3-nitro-4-methylphenol, 2-Amino-5-nitro-4-methylphenol, 4-Amino-2-nitrophenol, 2-Amino-6-nitro-1-phenol-4-sulfonic acid, 6-Amino-4-nitro-1-phenol-2-sulfonic acid, 3-Aminophenol, p-Aminophenol, 2-Amino-1-phenol-4-sulfonic acid, 3-Amino-5-sulfosalicylic acid, 5-Amino-3-sulfosalicylic acid, 2-Amino-3,4,6-trichlorophenol, 4-(3-Carbazoylamino)phenol, 4-Chloro-2-(2,4-dinitroanilino)phenol, 5-Diethylamino-2-nitroso-4-methylphenol, 5-Diethylamino-2-nitrosophenol, 3-Diethylaminophenol, 3-Dimethylamino-4-methylphenol, ...
A chemical used in the preparation of inhibitors of mammalian carbonic anhydrase isoforms. It is also used in the preparation of quinoline tethered fluorescent carbon dots for regulated anticancer discovery. It is employed in the production of TB drugs, salicylic acid, amino stabilizer and developers. 3-Aminophenol has been used as a stabilizer of chlorine-containing thermoplastics, although its principal use is as an intermediate in the production of 4-amino-2-hydroxybenzoic acid this isomer is also employed as a hair colorant and as a coupler molecule in hair dyes.. ...
Proposed reaction mechanism for catalysis of the ring-cleavage of 2-aminophenol by APD. The O atoms from O2 are highlighted in red. ...
Disclosed are epoxy resin compositions comprising at least one polyglycidyl derivative of an aminophenol having the structure ##STR1## and at least one biphenyl anhydride having the structure ##STR2## wherein m is 1 or 2; wherein A is selected from the group consisting of ##STR3## WHEREIN EACH R.sup.o is individually a monovalent radical selected from the group consisting of hydrogen, halogen, hydroxy, alkyl radical having from 1 to 5 carbon atoms, alkoxy radical having from 1 to 5 carbon atoms and ##STR4## wherein R.sup.1 is an alkyl radical having from 1 to 5 carbon atoms; and wherein each R.sup.2 is individually a monovalent radical selected from the group consisting of hydrogen, halogen, alkyl radical having from 1 to 5 carbon atoms, --NO.sub.2, --COOH --SO.sub.3 H, and --NH.sub.2. The compositions are useful in such applications as molding resins, laminates, adhesives, coatings, and the like. The disclosed epoxy resin-anhydride
Product Name: 3-Aminophenol Synonyms: 1-Amino-3-hydroxybenzene;1-amino-3-hydroxybenzene[qr];3-amino-1-hydroxybenzene[qr];3-amino-pheno;3-hydroxyaniline[qr];3-Hydroxyanilinel AC;3-hydroxybenzenamine;Basf ursol eg CAS: 591-27-5 MF: C6H7NO MW: 109.13...
The kinetics of the auto-oxidation of 2-aminophenol (OAP) to 2-amino-phenoxazin-3-one (APX) was followed in air-saturated aqueous solutions and the influence of temperature and pH on the auto-oxidation rate was studied. The kinetic analysis was based on a spectrophotometric method following the increase of the absorbance of APX. The process follows first order kinetics according to the rate law-d[OAP]/dt=k′[OAP]. The experimental data, within the pH range 4-9.85, were analyzed using both differential and incremental methods. The temperature variation of the overall rate constant was studied at pH=9.85 within the range 25-50°C and the corresponding activation energy was evaluated ...
3-Aminophenol sulfate (2:1) | C12H16N2O6S | CID 163205 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
The ir absorption spectra of the isomeric aminophenols have been recorded in the range 250-4000 cm,sup,−1,/sup,. The observed bands have been analyzed in terms of fundamentals, combinations, and overtones of a number of frequencies. These frequencies have been assigned to different modes of vibrations.. PDF Article ...
This was a phase 3 study in subjects with cystic fibrosis (CF) age 12 years and older who have a G551D-CFTR mutation and percent predicted forced expiratory volumn in 1 second (FEV1) between 40% and 90%.. Based on in vitro studies and pharmacologic, pharmacokinetic (PK), and safety profiles, ivacaftor was selected for clinical development as a possible treatment for patients with CF. Patients with the G551D mutation were the targeted population for this study because ivacaftor is a potentiator of the gating function of the CFTR protein, and the most prevalent mutation with a gating defect in CF is the G551D mutation.. This study was designed to further evaluate the efficacy of ivacaftor in subjects with CF who have a G551D-CFTR gene mutation and to evaluate safety in this population over a longer period than previously studied. ...
This was a phase 3 study in subjects with cystic fibrosis (CF) age 12 years and older who have a G551D-CFTR mutation and percent predicted forced expiratory volumn in 1 second (FEV1) between 40% and 90%.. Based on in vitro studies and pharmacologic, pharmacokinetic (PK), and safety profiles, ivacaftor was selected for clinical development as a possible treatment for patients with CF. Patients with the G551D mutation were the targeted population for this study because ivacaftor is a potentiator of the gating function of the CFTR protein, and the most prevalent mutation with a gating defect in CF is the G551D mutation.. This study was designed to further evaluate the efficacy of ivacaftor in subjects with CF who have a G551D-CFTR gene mutation and to evaluate safety in this population over a longer period than previously studied. ...
In our case report we illustrate a positive effect of ivacaftor on the sinonasal pathology in a 17 year old patient with CF. Her CF genotype showed a heterozygous deltaF508/S1251N mutation, in which the S1251N mutation is a type III mutation and can therefore be influenced by ivacaftor. In addition to her pulmonary symptoms she chronically suffered from headaches and nasal obstruction, most likely caused by chronic rhinosinusitis. During these complaints two CT-sinuses were performed (fig. 1A and 1B), showing opacification of all paranasal sinuses. Despite accurate treatment of the rhinosinusitis, with nasal irrigations, nasal steroids complaints persisted. After 5 months of ivacaftor use, a new CT-sinus (fig. 1C) showed complete resolution of the opacification of the paranasal sinuses and a decrease in symptoms of sinonasal disease. This positive effect of ivacaftor on sinonasal pathology seems promising, therefore more research is needed to evaluate the effect of ivacaftor on the upper airways ...
Cystic Fibrosis (CF) is caused by loss-of-function mutations of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene encoding a phosphorylation-activated, but ATP-gated chloride channel. Previous studies suggested that VX-770 (ivacaftor), a CFTR potentiator now used in clinics, increases the open probability (Po) of CFTR by shifting the gating conformational changes to favor the open channel configuration. Lately, another CFTR potentiator NPPB was reported to enhance CFTR activity through a modus operandi that exploits the ATP hydrolysis-driven, non-equilibrium gating mechanism unique to CFTR. Surprisingly however, NPPB increased the activity of non-hydrolytic G551D-CFTR, the third most common disease-associated mutation. Here, the mechanism of NPPB is investigated by assessing NPPBs interaction with well-studied VX-770. Interestingly, once G551D-CFTR was maximally potentiated by VX-770, NPPB further increases its activity. However, quantitative analysis of this drug-drug ...
hi, can one vary the level of p-aminophenol in parodinal by increasing the amount of paracetamol? or is the process of converting paracetamol to...
Metalloproteins utilize O2 as an oxidant, and they often achieve a 4-electron reduction without H2O2 or oxygen radical release. Several proteins have been designed to catalyze one or two-electron oxidative chemistry, but the de novo design of a protein that catalyzes the net 4-electron reduction of O2 has not been reported yet. We report the construction of a diiron-binding four-helix bundle, made up of two different covalently linked ?2 monomers, through click chemistry. Surprisingly, the prototype protein, DF-C1, showed a large divergence in its reactivity from earlier DFs (DF: due ferri, two iron). DFs release the quinone imine and free H2O2 in the oxidation of 4-aminophenol in the presence of O2, whereas FeIII-DF-C1 sequesters the quinone imine into the active site, and catalyzes inside the scaffold an oxidative coupling between oxidized and reduced 4-aminophenol. The asymmetry of the scaffold allowed a fine-engineering of the substrate binding pocket, that ensures selectivity.Not just a ...
Our main intermediates are Red base KD, Diphenyl ether, Biphenyl, 2-aminophenol, 4,4-Bis(chloromethyl)-1,1-biphenyl(BCMB), p(o,m)-toluic acid, Terephthalaldehyde, 4,4-Biphenyldicarboxaldehyde, 4,4-Dimethylbiphenyl, 3-Chloro-2-methylaniline, o-Anisaldehyde,Decahydronaphthalene, p-Toluoyl Chloride , 2-Chlorothioxanthone, Benzaldehyde-2-sulfonic acid sodium, p(o,m)-Tolunitrile, Ferrocene ...
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Here a novel electrochemical method for the rapid detection of anti-HIV antibodies in serum is presented. The novelty lies in the combination of allosteric enzymes and coulometry to yield a fast, simple and reliable HIV diagnostic method. We have used a previously developed β-galactosidase enzyme that is efficiently activated by anti-HIV antibodies directed against a major B-cell epitope of the gp41 glycoprotein. When these antibodies bind the enzyme, the 3D conformation changes positively affecting the performance of the active site and, consequently, the enzyme activity is stimulated. Using 4-aminophenyl β-d-galactopyranoside (PAPG) as substrate yields p-aminophenol (PAP), which is reversibly oxidised at a very mild potential, ca. 0.37 V vs. Ag/AgCl over a range of electrode materials within the working pH range of β-galactosidase. In the present case, photolithographically produced microelectrode arrays resulted in a detection limit of 4 μM for 4-aminophenol (PAP). The presence of ...
1. Compared with a large number of similar substances p-aminophenol is the most active in inhibiting the oxygen uptake of liver suspension. It has no effect on the production of carbon dioxide.. 2. The quinoid form of the drug is responsible for the inhibition. The optimum concentration is m/10,000.. 3. The inhibition of the oxygen uptake of liver varies between 50 and 60 per cent at pH 6.4 and pH 6.7. Brain and kidney are inhibited 40 and 27 per cent respectively. There is no inhibition at pH 7.8.. 4. A large number of substances which are oxidized by liver including succinate, lactate, amino acids, choline, tyramine and alcohol were unaffected by the quinoid form of p-aminophenol. But the oxidation of xanthine was inhibited completely by a concentration of m/20,000 at pH 6.4 and 6.7 and inhibited 50 per cent at pH 7.8.. 5. Although related substances such as quinone and the oxidized forms of o-aminophenol and p-phenylene diamine inhibit the oxygen uptake of liver to a certain extent they have ...
Vertex Pharmaceuticals' ivacaftor drug, to be marketed as Kalydeco, reduced the incidence of pulmonary flare-ups in cystic fibrosis patients by 55% compared with a placebo, trial results show. It helps those with a certain genetic mutation but could have broader significance, a doctor says.
ORKAMBI (Lumacaftor,Ivacaftor) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Learn about Kalydeco (Ivacaftor) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
We,Suzhou City Xiangcheng Qingtai Fine Chemicals Co.,Ltd ,provide our product catalog : China 3-nitro-4-aminophenol, 3-nitro-4-hydroxyethylaminophenol, China 3-nitro-4-hydroxypropylaminophenol, 2-chloro-5-nitro aniline, China 2-methyl-6-chloro aniline,
Bimetallic nanoparticles have attracted significant attention as their electrochemical and catalytic properties being superior to those of the individual component nanoparticles. In this study, gold-silver hybrid nanoparticles (AuAgNPs) with an Aucore-Agshell nanostructure were successfully synthesized on zinc oxide (ZnO) whiskers. The as-prepared nanocatalyst, denoted [email protected] whisker, exhibits an excellent catalytic efficiency in the aqueous reduction of 4-nitrophenol to 4-aminophenol; the turnover frequency was up to 40 times higher than that of each component nanoparticle. Their unique features were attributed to the electronic ligand effect at the bimetallic interface. In addition, the AuAgNPs were synthesized on a ZnO whisker-containing paper with a fiber-network microstructure, which was prepared via a papermaking technique. The paper-structured AuAgNPs composite possessed both a paper-like practical utility and a good catalytic performance. Furthermore, the on-paper synthesis process for
Pseudomonas knackmussii B13 was the first strain to be isolated in 1974 that could degrade chlorinated aromatic hydrocarbons. This discovery was the prologue for subsequent characterization of numerous bacterial metabolic pathways, for genetic and biochemical studies, and which spurred ideas for pollutant bioremediation. In this study we determined the complete genome sequence of B13 using next generation sequencing technologies and optical mapping. Genome annotation indicated that B13 has a variety of metabolic pathways for degrading monoaromatic hydrocarbons including chlorobenzoate, aminophenol, anthranilate, and hydroxyquinol, but not polyaromatic compounds. Comparative genome analysis revealed that B13 is closest to Pseudomonas denitrificans and Pseudomonas aeruginosa. The B13 genome contains at least 8 genomic islands (prophages and integrative conjugative elements - ICE), which were absent in closely related pseudomonads. We confirm that two ICE are identical copies of the 103-kb ...
The diamagnetic title complexes were obtained from Ru(acac)(2)(CH3CN)(2) and 2-aminophenol or 2-aminothiophenol. X-ray structure analysis of (L-1)Ru(acac)(2) (L-1 = o-iminoquinone) revealed C-C intra-ring, C-O, and C-N distances which suggest a Ru-III-iminosemiquinone oxidation state distribution with antiparallel spin-spin coupling. One-electron oxidation and reduction of both title compounds to paramagnetic monocations [(L)Ru(acac)(2)](+) or monoanions [(L)Ru(acac)(2)](-) occurs reversibly at widely separated potentials (DeltaE , 1.3 V) and leads to low-energy shifted charge transfer bands. In comparison with clearly established Ru-II-semiquinone or Ru-III-catecholate systems the g tensor components 2.23 , g(1) , 2.09, 2.16 , g(2) , 2.07, and 1.97 , g(3) , 1.88 point to considerable metal contributions to the singly occupied MO, corresponding to Ru-III complexes with either o-quinonoid (--, cations) or catecholate-type ligands (--, anions) and only minor inclusion of Ru-IV- or ...
94 STAT. 2558. PUBLIC LAW 96-490-DEC. 2, 1980 (iv) by amending the article description for item 404.32 to read as follows: "Naphthalic anhydride; Phthalic acid; and 4-Sulfo-l,8-naphthalic anhydride"; (v) by striking out "p-Aminobenzoylaminonaphthalene sulfonic acid;" "Aminophenol, substituted;", "3-(N-Ethylanilino)propionic acid, methyl ester;", "l-(p-Nitrophenvl)-2amino-l,3-propanediol;", and "Toluidine carbonate; in item 404.84: (vi) by amending item 404.92- (I) by striking out "p-Acetaminobenzaldehyde;", (II) by inserting "3-(N-Ethylanilino)propionic acid, methyl ester;" immediately after "4-Dimethylaminobenzaldehyde;", (III) by inserting "l-(p-Nitrophenyl)-2-amino-l,3-propanediol;" immediately after "2-Methyl-p-anisidine [NH2=1];", (IV) by striking out "Nitra acid amide (1-Amino9,10-dihydro-N-(3-methoxypropyl)-4-nitro-9, lO-dioxo-2anthramide); and "; and (V) by inserting "; and Toluidine carbonate" immediately after "\-Phenylalanine"; (vii) by amending item 405.28- (I) by inserting ...
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1L4N: Structural studies of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica: the apo, substrate, and product-aldimine complexes.
... - Browse fuzing.com to find O-aminophenol sellers, suppliers, wholesalers, companies, manufacturers, exporters, factories.
CFTRV232D is a rare CF-causing mutation (2) that impairs protein folding and trafficking to the surface membrane (9). The frequency of CFTRV232D occurrence is low in the global population of CF patients but is considered common in cohorts of Spanish CF patients (3). Yet the mechanism by which the V232D mutation causes CF is not well documented, and whether patients with this mutation can be treated with modulators of CFTR folding and channel activity is not clear. V232 is located in TM region 4 of membrane-spanning domain 1 and, therefore, is predicted to be embedded in the lipid bilayer. The V232D mutation is proposed to cause aberrant hydrogen bonding between TM4 and adjacent TM segments in CFTR (24). This folding defect may explain why the vast majority of CFTRV232D is selected for premature degradation and fails to reach the cell surface. Yet a small quantity of CFTRV232D can fold and accumulate at the cell surface. Interestingly, single-channel recordings demonstrate that CFTRV232D is a ...
Abstract CuCo2O4 spinel nanoparticles were successfully preparedvia a sol-gel method, which were firstly employed in catalytic reduction of p-nitrophenol to produce p-aminophenol. CuCo2O4...
-2013 investment focused on key development programs in cystic fibrosis, hepatitis C and autoimmune diseases- -First two Breakthrough Therapy Designations from U.S. FDA granted to ivacaftor monotherapy and to the combination regimen of VX-809 and ivacaftor for the treatment of cystic...
Hi, I have been waiting 8 years for Ivacaftor to be approved for residual function CFTR mutations. The day finally came on May 17th and soon after, we had my son signed up and taking his first dose. We did this with a little trepidation based on the results of a small N-of-1 study (https://www.ncbi.nlm.nih.gov/pubmed/28068001) where Ivacaftor had the opposite effect for 2 of the people in the study; both with the A455E defect. I thought how can that be possible with all the preclinical work
-Agreement provides access to ORKAMBI for people who have two copies of the F508del mutation and expands access to KALYDECO for all eligible patients- LONDON--(BUSINESS WIRE)-- Vertex Pharmaceuticals Incorporated (Nasdaq:VRTX) today announced it has reached an...
Read about how to correctly administer KALYDECO oral granules. See Important Safety Information and full Prescribing Information.
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A combination of two drugs - lumacaftor and ivacaftor - improves lung function in children aged 6-11 with cystic fibrosis within 15 days of treatment, according to a phase 3 trial published in...
In a big win for Cambridge-based Vertex Pharmaceuticals, the US Food and Drug Administration today approved the companys drug Kalydeco (ivacaftor) to treat a rare form of cystic fibrosis. The drug is approved for patients ages 6 and over who carry the G551D gene mutation, and the news follows the approval last year of Vertexs hepatitis C drug Incivek.
Kalydeco (ivacaftor) and lumacaftor address the underlying cause of CF rather than just symptoms of the disease, in which a missing or defective protein called CFTR results in poor flow of salt and water into and out of cells in the lungs. That causes a buildup of thick, sticky mucus that can lead to chronic lung infections, progressive lung damage and death at an early age ...
This information and facts can then be employed to re construct cell signaling events, transcription factors in volved Ivacaftor VX-770 and mechanisms particip
Mouse monoclonal antibody raised against a full-length recombinant EPN3. EPN3 (AAH01038.1, 1 a.a. ~ 208 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00055040-M) - Products - Abnova
The present disclosure provides compositions and methods for the biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid and the purification of biologically derived acetaminophen.
Our research work is divided into three chapters. In the first chapter, synthesis of substituted phenolic compounds including halogenated di- and trihydroxybenzenes, aminophenols, and substituted di-tert-butylphenols, their redox potential, laccase oxidation, and mosquito anti-larval activities are discussed. The synthesized substituted phenols were found to be the substrates but not the inhibitors of laccase. An inverse correlation between the oxidation potential and the laccase oxidation efficiency of halogenated hydroxybenzenes and aminophenols was established. However, substituted di-tert-butylphenols were found to have anti-larval activities in mosquitoes resulting in the death of the larvae just before reaching pupation. Among the di-tert-butyl phenols studied, water insoluble, 2,4-di-tert-butyl-6-(3-methyl-2-butenyl)phenol (16), 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-methylpropanal oxime (14), and 6,8-di-tert-butyl-2,2-dimethyl-3,4-dihydro-2H-chromene (17) caused the mortility of 98%, ...
A method for making poly-aminophenol based hybrid material by in-situ polymerization of aminophenol using palladium acetate as the oxidant is described. The oxidative polymerization of aminophenol leads to the formation of poly-aminophenol, while the reduction of palladium acetate results in the formation of palladium nanoparticles. The palladium nanoparticles were found to be highly dispersed and stabilized throughout the polymer matrix. This hybrid nanocomposite material showed excellent catalytic efficiency with respect to Heck, Suzuki-Miyaura and Sonogoshira coupling reactions.
Exiguobacterium sp. ATCC ® BAA-1283D-5™ Designation: Genomic DNA from Exiguobacterium sp. strain AT1b TypeStrain=False Application:
Exiguobacterium sp. ATCC ® BAA-1283D-5™ Designation: Genomic DNA from Exiguobacterium sp. strain AT1b TypeStrain=False Application:
CFP : Confirmation of a clinical diagnosis of cystic fibrosis   Risk refinement via carrier screening for individuals in the general population   Prenatal diagnosis or familial mutation testing when the familial mutations are included in the 106-mutation panel listed above (if familial mutations are not included in the 106-mutation panel, order FMTT / Familial Mutation, Targeted Testing)   Risk refinement via carrier screening for individuals with a family history when familial mutations are not available   Identification of patients who may respond to CFTR potentiator therapy
0076] Further suitable dyes for colouring hair within the meaning of the present invention are those of neutral nitro dyes. Suitable non-limiting examples are HC Blue No. 2, HC Blue No. 4, HC Blue No. 5, HC Blue No. 6, HC Blue No. 7, HC Blue No. 8, HC Blue No. 9, HC Blue No. 10, HC Blue No. 11, HC Blue No. 12, HC Blue No. 13, HC Brown No. 1, HC Brown No. 2, HC Green No. 1, HC Orange No. 1, HC Orange No. 2, HC Orange No. 3, HC Orange No. 5, HC Red BN, HC Red No. 1, HC Red No. 3, HC Red No. 7, HC Red No. 8, HC Red No. 9, HC Red No. 10, HC Red No. 11, HC Red No. 13, HC Red No. 54, HC Red No. 14, HC Violet BS, HC Violet No. 1, HC Violet No. 2, HC Yellow No. 2, HC Yellow No. 4, HC Yellow No. 5, HC Yellow No. 6, HC Yellow No. 7, HC Yellow No. 8, HC Yellow No. 9, HC Yellow No. 10, HC Yellow No. 11, HC Yellow No. 12, HC Yellow No. 13, HC Yellow No. 14, HC Yellow No. 15, 2-Amino-6-chloro-4-nitrophenol, picramic acid, 1,2-Diamino-4-nitrobenzol, 1,4-Diamino-2-nitrobenzol, 3-Nitro-4-aminophenol, ...
An oil soluble dispersant comprising the reaction products of: (1) oil soluble salts, amides, imides, oxazolines, esters, or mixtures thereof of long chain hydrocarbyl substituted mono- and dicarboxylic acids or their anhydrides; (ii) long chain hydrocarbon having a polyamine attached directly thereto; (iii) Mannich condensation product formed by condensing a long chain hydrocarbyl substituted hydroxy aromatic compound with an aldehyde and a polyalkylene polyamine; and (iv) Mannich condensation product formed by reacting long chain hydrocarbyl substituted mono or dicarboxylic acids or their anhydrides with an aminophenol, which may be optionally hydrocarbyl substituted, to form a long chain hydrocarbyl substituted amide or imide-containing phenol intermediate adduct, and condensing said long chain hydrocarbyl substituted amide or imide-containing phenol adduct with aldehyde and polyamine; said adduct containing at least one reactive group selected from reactive amino groups and reactive hydroxyl groups;
Two complementary approaches for the direct synthesis of 2-dichloro- and 2-trichlorobenzoxazoles from 2-aminophenols and halogenated nitriles are reported. A green, noncatalyzed method was shown to proceed in an alc. solvent without the addn. of exogenous acid or base. This method provides a clean and robust synthesis of these important heterocycles, which contain a key functional group handle at the 2-position. A complementary platinum multifaceted catalysis approach was also developed in which the metal can catalyzes multiple mechanistically distinct processes. This method allows for an improved use of the metal catalyst vs stepwise protocols and provides increased flexibility in the choice of reaction conditions. [on SciFinder(R)]. ...
l Patent No. US 6,635,241 B1: Henkel Kga, Düsseldorf, Germany, patented a method to dye hair by applying an effective amount of aminophenol derivatives and oxidizing them on the hair.
One Chinese firm gave a "certificate of authenticity" but it was absurd. The certificate stated a combination of hydroquinone, potassium bromide, sodium sulfite and sodium carbonate ie just some rudimentary crappy development brew. Does anyone have any information on how HEAP was made? At least then, when Im getting information from these Chinese firms, I can ask the steps that were used in the manufacture if they quote things that are chemically unlikely, Ill steer clear. The fact that about ten Chinese firms have offered me this chemical makes me suspicious. However, there is a CAS number for "2 Beta hydroxy phenyl aminophenol" and also a CAS number for the same chemical in the "cresol" form. If I could only get a CAS number for HEAP Sulphate then at least there is a accurate specification. The problem with dealing with Chinese firms is that they will always have a getout by saying " sorry, we misunderstood". A CAS number eliminates this entirely. Any information appreciated ...
A tridentate benzoxazole-containing aminophenol ligand HLBAP was synthesized and complexed with CuII. The resulting CuII complexes were characterized by X-ray, IR, UV-vis-NIR spectroscopies, and magnetic susceptibility studies, demonstrating that the ligand is oxidized to the o-iminosemiquinone form [LBIS]−
1. Pneumococci in contact with hemoglobin transform this into methemoglobin. This reaction occurs only when the pneumococci are living; it is not induced by the culture fluid or by extracts of the bacteria.. 2. The reaction does not occur when hemoglobin is added to an emulsion of washed pneumococci in salt solution. However, if minute traces of dextrose be added to such a mixture, the reaction quickly occurs. The dextrose may be replaced by any one of a number of other sugars, and also by certain other organic substances, if the latter are added in large amounts. Certain other organic substances are not able to replace dextrose, but it has been impossible to determine any special molecular configuration on which this property depends.. 3. The formation of methemoglobin by pneumococci probably resembles the formation of methemoglobin by certain chemical substances, such as aminophenol.. 4. From the work of others it is probable that the formation of methemoglobin is always a reaction of ...
2] https://www.ncbi.nlm.nih.gov/pubmed/?term=Analytical%20and%20Biological%20Variation%20in%20Repeated%20Sweat%20Chloride%20Concentrations%20in%20Clinical%20Trials%20for%20CFTR%20Modulator% ...
Although all-trans-retinoic acid (ATRA) provides protection against a variety of conditions in vivo, particularly ischemia, the molecular mechanisms underpinning these effects remain unclear. The present studies were designed to assess potential mechanisms by which ATRA affords cytoprotection against renal toxicants in LLC-PK1 cells. Pretreatment of LLC-PK1 cells with ATRA (25 μM) for 24 hr afforded cytoprotection against oncotic cell death induced by p-aminophenol (PAP), 2-(glutathion-S-yl)hydroquinone (MGHQ), and iodoacetamide but not against apoptotic cell death induced by cisplatin. Inhibition of protein synthesis with cycloheximide blunted ATRA protection, indicating essential cell survival pathways must be engaged prior to toxicant exposure in order to provide cytoprotection. Interestingly, ATRA did not prevent the PAP-induced generation of ROS, nor did it alter glutathione levels. Moreover, ATRA had no significant effect on Nrf2 protein expression, and the Nrf2 inducers sulforaphane and ...
It is accepted that acetominiphen (APAP) hepatocellular injury requires bioactivation by cytochromes P450 (P450s), but this remains unproven in primary mouse hepatic parenchymal cells (HPCs). The present study evaluated APAP cytotoxicity and APAP-protein adducts (a biomarker of metabolic bioactivation) using primary mouse HPCs in the presence and absence of a broad-spectrum inhibitor of P450s, 1-aminobenzotriazole (1-ABT). 1-ABT abolished formation of APAP-protein adducts at all concentrations tested, but eliminated cytotoxicity only at the low concentrations, indicating the presence of a P450-independent mechanism at larger APAP concentrations. P450-independent cell death was delayed in onset relative to toxicity observed at smaller concentrations and was related to p-aminophenol formation. In conclusion, APAP hepatocellular injury in vitro occurs by at least two mechanisms, and these findings should be considered when interpreting results from APAP cytotoxicity studies in vitro and in ...
The FDA has approved tezacaftor/ivacaftor and ivacaftor (Symdeko, Vertex Pharmaceuticals, Inc.) to treat the underlying cause of cystic fibrosis (CF) ...
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
Oral granules: Shake the packet gently before you open it. Pour the contents into 1 teaspoon of cold soft food or liquid (such as applesauce, pureed fruits or vegetables, yogurt, water, milk, or juice) and mix together. Give this mixture within 1 hour and make sure all medicine is taken. Give food that contains fat right before or right after you give the mixture ...
Large complex polygons were generated by shortening effect ascribing the differences in APDs with numerous points lying distant from the identity type of the Poincar plot. Moreover, while 0. 01 and 0. 1 mM terfenadine did not somewhat increase STV during 0. 5 Hz, higher levels induced a decrease that became significant at 10 mM. Additionally, throughout the transition towards the steady state reduction in APD in Ivacaftor solubility LVMMs, terfenadine induced a marked upsurge in temporal BVR at 1 Hz. Figure 2A shows that before the shortening effect of 1 mM terfenadine, the progression towards the plateau phase of the AP, although not APD, was affected. Even though between 198 and records 170, the best shift of the development phase became more pronounced, and the plateau phase was depressed, APD wasnt afflicted, and terfenadine caused the loss in AP dome. During the transition to the steady-state decline in APD, large variations in effective APDs were seen. Four out-of 10 myocytes showed this ...
of prostate cancer. When this compound was administered to ovariectomized mature female rats for 2 months researchers found it increased BMD and the biomechanical strength of cortical bone in the femur. These findings show that the effects of S-40503 on bone is applicable to both males and females. Rats treated with only estrogen a hormone used to prevent or minimize bone breakdown (resorption) did not positively affect BMD or cortical bone strength.. Please select the Card Type. Please enter a Security Code. LastName is required field.. When Cardarine is administered in excessively high doses in rats over a relatively long period of time the compound may cause cancer. SARMs and AASs. In the Mk-2866 Phytochemical Selective Androgen Receptor Modulator fitness community this compound is most commonly used to improve exercise endurance and assist in fat loss.. Exact Mass: 338. Molecular Weight: 338. Elemental Analysis: C 49. Shipped under ambient temperature as non-hazardous chemical. This product ...
Follow-up testing to identify mutations in individuals with a clinical diagnosis of cystic fibrosis (CF) and a negative targeted mutation analysis for the common mutations. Identification of mutations in individuals with atypical presentations of CF (eg, congenital bilateral absence of the vas deferens or pancreatitis). Identification of mutations in individuals where detection rates by targeted mutation analysis are low or unknown for their ethnic background. Identification of patients who may respond to cystic fibrosis transmembrane conductance regulator (CFTR) potentiator therapy. This is not the preferred genetic test for carrier screening or initial diagnosis. For these situations, order CFB / Cystic Fibrosis Mutation Analysis, 106-Mutation Panel. ...
Abstract : O-aminophenol has extensive uses as a conducting material and in electrochemical devices. The objectiveof this research was to investigate the influence of biofield energy treatment on the physical thermal and spectralproperties of o-aminophenol. The study was performed in two groups; the control group was remained as untreated,while the treated group was subjected to Mr. Trivedis biofield energy treatment. Subsequently, the control andtreated o-aminophenol samples were characterized by X-ray diffraction (XRD), Differential scanning calorimetry(DSC), Thermogravimetric analysis (TGA), surface area analysis, Fourier transform infrared (FT-IR) spectroscopy,and Ultra violet-visible spectroscopy analysis (UV-vis). The XRD analysis showed an increase in peak intensity ofthe treated o-aminophenol with respect to the control. Additionally, the crystallite size of the treated o-aminophenolwas increased by 34.51% with respect to the control sample. DSC analysis showed a slight increase in the ...
Pseudomonas pseudoalcaligenes CECT5344 tolerates cyanide and is also able to utilize cyanide and cyano-derivatives as a nitrogen source under alkaline conditions. The strain is considered as candidate for bioremediation of habitats contaminated with cyanide-containing liquid wastes. Information on the genome sequence of the strain CECT5344 became available previously. The P. pseudoalcaligenes CECT5344 genome was now resequenced by applying the single molecule, real-time (SMRT()) sequencing technique developed by Pacific Biosciences. The complete and finished genome sequence of the strain consists of a 4,696,984 bp chromosome featuring a GC-content of 62.34%. Comparative analyses between the new and previous versions of the P. pseudoalcaligenes CECT5344 genome sequence revealed additional regions in the new sequence that were missed in the older version. These additional regions mostly represent mobile genetic elements. Moreover, five additional genes predicted to play a role in sulfoxide ...
article{31e17f38-485f-4324-be67-f72cc473b767, abstract = {Both the antibody affinity and the detectability of the label are essential in deciding the final characteristics of a heterogeneous immunoassay. This paper describes an approach to obtain a supplementary enhancement of the signal generated by using an enzyme label, e.g., by including the product of the enzymatic reaction in an additional amplification cycle during the detection step performed with an amperometric biosensor based on glucose dehydrogenase (GDH). An immunoassay format with a labelled analyte derivative that competes with the analyte present in the sample for a limited amount of antibody binding sites was employed. The beta-galactosidase label hydrolyses the substrate aminophenyl-beta-galactopyranoside, and the generated aminophenol enters then into a bioelectrocatalytic amplification cycle at the GDH biosensor. The principle was applied for determination of 4-nitrophenol, with the best minimal concentration of 1.5 microM ...
We report that men who do not have homozygous deletions at GSTT1 (i.e., whose GST-θ protein is presumably expressed and functional) are at increased CaP risk. Although our results are largely hypothesis generating, these findings are consistent with knowledge that GST-θ produces genotoxic metabolites in response to specific exposures (1, 2, 3) . There is substantial evidence that glutathione S conjugates derived from halogenated alkanes, halogenated alkenes, hydroquinones, quinones, aminophenols, and other compounds can cause cellular and DNA damage (reviewed in Ref. 10 ). Many of these compounds are commonly found as occupational exposures, and some are known carcinogens. Glutathione metabolic intermediates from ethylene dibromide, 1,2,3,4-diepoxybutane, methyl bromide, epibromohydrin, 1,3-dichloroacetone, and methylene chloride are mutagenic (1 , 2) . Epidemiological evidence has provided further support that these compounds may be involved in prostate carcinogenesis. For example, cellulose ...
A process for the direct production of aminophenol and N-acetyl-p-aminophenol from nitrophenols using a borate ion additive during hydrogenation to eliminate undesirable by-products and color formation.
Ligands findings suggest the potential for LGD-3303 to be useful either as a single agent or in combination with conventional bisphosphonate therapy. The data suggest that LGD-3303 may provide a safe and effective new drug for the treatment of osteoporosis, including in patients that have had an inadequate response to bisphosphonate treatment.. SARM Program. Ligand has conducted extensive drug research with SARMs. In its research collaboration with TAP Pharmaceutical Products, Ligand discovered the SARM LGD-2941, which TAP is developing in a Phase I clinical trial. Ligand has rights to several SARM molecules. In addition to LGD-3303, Ligand is formulating and optimizing a library of SARM compounds to potentially advance to clinical development.. About Ligand Pharmaceuticals. Ligand discovers and develops new drugs that address critical unmet medical needs of patients in the areas of thrombocytopenia, hepatitis C, cancer, hormone-related diseases, osteoporosis and inflammatory diseases. Ligands ...
Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer. Curr Opin Support Palliat Care. PubMed PMID: 24189892. Mk-2866 Sarms Update basaria S Collins L Dillon EL Orwoll K Storer TW Miciek R Ulloor J Zhang A Eder R Zientek H Gordon G Kazmi S Sheffield-Moore M Bhasin S. The safety pharmacokinetics and effects of LGD-4033 a novel nonsteroidal oral selective androgen receptor modulator in healthy young men. J Gerontol A Biol Sci Med Sci. Epub 2012 Mar 28.. MITT population had stair climb power assessed at baseline and week 16. Among NSCLC subjects 28 were included in the physical function analysis. GTx-024 was well tolerated and showed a statistically significant and clinically relevant improvement in physical function in NSCLC subjects. These data provide evidence that GTx-024 may play an important role in the management of patients with NSCLC. Further research is needed to assess the effect of GTx-024 on overall survival. American Society ...
Many people with cystic fibrosis are counting on cystic fibrosis transmembrane conductance regulator modulators to improve their overall health. Im learning that they have effects I hadnt counted on.
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Cystic fibrosis (CF), a common inherited disease, is caused by mutations in the gene CF transmembrane conductance regulator (CFTR). This gene encodes the CFTR protein, which is located on the apical surface of the epithelial cells and has many functions, the most important of which is thought to be ion transport. Abnormal ion transport leads to accumulation of thick secretions in the airways, infection, inflammation and eventually irreversible lung damage. There is currently no treatment that has been demonstrated to halt the natural progression of the disease; all available successful therapies merely slow down the rate of decline in clinical condition, which still leads to premature death. The first therapy to target the CFTR defect directly has recently been approved in the USA and the European Union: treatment with ivacaftor (marketed as Kalydeco) resulted in significant improvements in lung function, exacerbation rate, weight gain and quality of life in patients with the G551D mutation.1 ...
Vertex Pharmaceuticals Inc. (Nasdaq: VRTX) announced positive data from a Phase 2 trial [1] of a second drug candidate, in addition to Kalydeco, aimed at treating cystic fibrosis. The company said it plans to start pivotal, or Phase 3, trials on VX-809 next year.. VX-809 was tested in combination with Kalydeco, or ivacaftor, a drug for which Vertex received approval earlier this year in both the U.S. [2] and in Europe for treatment of the most common mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, F508del. ...
Results of a new drug trial suggest the next generation of medications, known as CFTR modulators, show potential to correct the genetic defect that causes cystic fibrosis and halt the diseases destructive progression.
VRTX complete enrollment in VX-661 + ivacaftor phase 3 trial in F508del / residual function mutation CF patients [PR, delayed from prior mid-2016 guidance at #NACFC15 and size decreased from N=300 to 200, reiterated 7/2016] ...
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Blood pressure and heart rate: This medication may cause an increase in blood pressure and a decrease in heart rate. If you have increased blood pressure (hypertension) or a low heart rate, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.. Cataracts: Cataracts have been reported in children treated with ivacaftor without lumacaftor. Your doctor may recommend eye examinations before and during treatment with this medication.. Kidney function: The safety and effectiveness of ivacaftor-lumacaftor have not been established for people ...
You only need 6gms per litre (of N-(beta-hydroxyethyl)-o-aminophenol sulfate). Assuming your developing tank takes 500mls - and if you go for the 1:3 dilution "one shot" of Promicrol (superb acutance with no perceptible increase in grain), then I litre will give 4 litres of working solution - ie 8 films can be developed from each litre. I can sell the N-(beta-hydroxyethyl)-o-aminophenol sulfate for $25 per 100gms. (Plus postage) - That will develop over 100 36 exposure films. ie 25c per film (plus the cost of the glycin, sodium sulphite etc - ie very little ...
According to a recently published report, the Nitrobenzene Market is expected to grow at the CAGR of % during 2015-2022. The segmentation of GLOBAL NITROBENZENE MARKET is based on application, type, metal derivatives and geography. The report on GLOBAL NITROBENZENE MARKET Forecast2015-2022 (byapplication, type, metal derivative and geography) provides.... ...
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2-Bromo-1,3,5-tris(2,2-dimethylpropyl)-4-nitrobenzene/ACM40572234 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
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Exiguobacterium sp. RMA utilized 4-chloroindole as its sole source of carbon and energy. The effect of initial concentrations of substrate on the 4-chloroindole degradation was studied and observed that strain PMA was capable of degrading 4-chloroindole up to concentration of 0.5 mM. The degradation pathway of 4-chloroindole was studied for Exiguobacterium sp. PMA based on metabolites identified by gas chromatography-mass spectrometry. 4-Chloroindole was initially dehalogenated to indole that was further degraded via isatin, anthranilic acid, and salicylic acid. The potential of strain PMA to degrade 4-chloroindole in soil was monitored using soil microcosms, and it was observed that the cells of strain PMA efficiently degraded 4-chloroindole in the soil. The results of microcosm studies show that strain PMA may be used for bioremediation of 4-chloroindole-contaminated sites. This is the first report of the bacterial degradation of 4-chloroindole. (C) 2014 Elsevier B.V. All rights reserved ...
Four inks for the production of ZnO semiconducting films have been prepared with zinc acetate dihydrate as precursor salt and one among the following aminoalcohols: aminopropanol (APr), aminomethyl butanol (AMB), aminophenol (APh) and aminobenzyl alcohol (AB) as stabilizing agent. Their thermal decomposition process has been analyzed in situ by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and evolved gas analysis (EGA), whereas the solid product has been analysed ex-situ by X-ray diffraction (XRD) and infrared spectroscopy (IR). Although, except for the APh ink, crystalline ZnO is already obtained at 300 ºC, the films contain an organic residue that evolves at higher temperature in the form of a large variety of nitrogen-containing cyclic compounds. The results indicate that APr can be a better stabilizing agent than ethanolamine (EA). It gives larger ZnO crystal sizes with similar carbon content. However, a common drawback of all the amino stabilizers (EA included) ...
Drug testing for Duchenne MD, Leigh syndrome and Pompe disease moves forward; and two MDA-supported mouse studies suggest leads for myasthenia gravis and periodic paralysis ...
Vishwakarma Singh and co-workers from IIT Bombay have published in Organic and Biomolecular Chemistry on an oxidation of a phenol that yields a Diels-Alder substrate that dimerizes on itself and when the dimer is heated reforms the dienone substrate that undergoes an intramolecular Diels-Alder reaction. So the sequence goes like so: intermolecular Diels-Alder to retro-Diels-Alder…
New advances in cystic fibrosis medical research announced in June have been welcomed by the Cystic Fibrosis Trust as it stands to benefit up to half of all people living with cystic fibrosis in the UK.. The results, released by Vertex Pharmaceuticals Ltd, of a phase III trial for a new treatment for people with cystic fibrosis aged 12 and over with two copies of the F508del mutation, demonstrate that a combination of the drugs ivacaftor and lumacaftor could offer additional treatment to address the underlying cause of the disease and increase lung capacity.. Janet Allen, Director of Care and Research for the Cystic Fibrosis Trust said: "We are pleased to see these promising results, which open up a new front in the fight against cystic fibrosis. This new combination therapy looks set to be an important additional treatment option that could improve the lives of many people with cystic fibrosis. As this leading edge of science continues to be explored and better understood, we are hopeful that a ...
BOSTON and DURHAM, NC - Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) and Parion Sciences today announced that the companies will collaborate to develop investigational epithelial sodium channel (ENaC) inhibitors for the potential treatment of cystic fibrosis (CF) and other pulmonary diseases. Under the agreement, Vertex gains worldwide development and commercial rights to Parions investigational ENaC inhibitors, including P-1037 and P-1055, for CF and other pulmonary diseases. P-1037 is currently being evaluated in an exploratory Phase 2a study in people with CF, regardless of genotype, and Vertex and Parion plan to begin an additional Phase 2a study that adds P-1037 to treatment with the investigational combination of lumacaftor and ivacaftor for people with CF who have two copies of the F508del mutation. Parion will receive an $80 million up-front payment from Vertex with the potential to receive additional development and regulatory milestone payments and tiered royalties related to ...
1-Chloro-2,4-dimethyl-5-nitrobenzene 69383-68-2 NMR spectrum, 1-Chloro-2,4-dimethyl-5-nitrobenzene H-NMR spectral analysis, 1-Chloro-2,4-dimethyl-5-nitrobenzene C-NMR spectral analysis ect.
Restoration of just 5% of wild-type CFTR function dramatically improves lung and gut function in CF patients [71]. Research efforts into CF therapy development have generated drugs that can be divided into the different classes of potentiators or correctors, both of which will be discussed in more detail. In addition, the possibility of developing compounds that activate alternative Cl- and K+ channels to compensate for the loss of CFTR activity is promising according to studies in both HEK 293 cells and IB3-1 cells, which were isolated from a CF patient expressing the ΔF508 mutation. In these studies, the cells show an increase in Cl- transport due to manipulation of ClC-2 channels through extracellular pH or by arachidonic acid, amidation or acid-activated omeprazole [72, 73].. Potentiator drugs act to open up the malfunctioning CFTR channel, thereby promoting better ion and fluid trafficking through epithelia to relieve CF patient symptoms. This class of drugs is important for those CF ...
MolCore offers CAS No.16588-24-2, 4-Bromo-1-chloro-2-nitrobenzene for your research needs.Find product specific information including MFCD05863216,16588-24-2 MSDS,Price,Custom Synthesis.
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TY - JOUR. T1 - Drug Insight. T2 - Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. AU - Bhasin, Shalender. AU - Calof, Olga M.. AU - Storer, Thomas W.. AU - Lee, Martin L.. AU - Mazer, Norman A.. AU - Jasuja, Ravi. AU - Montori, Victor Manuel. AU - Gao, Wenqing. AU - Dalton, James T.. PY - 2006/3. Y1 - 2006/3. N2 - Several regulatory concerns have hindered development of androgens as anabolic therapies, despite unequivocal evidence that testosterone supplementation increases muscle mass and strength in men; it induces hypertrophy of type I and II muscle fibers, and increases myonuclear and satellite cell number. Androgens promote differentiation of mesenchymal multipotent cells into the myogenic lineage and inhibit their adipogenic differentiation, by facilitating association of androgen receptors with β-catenin and activating T-cell factor 4. Meta-analyses indicate that testosterone supplementation increases fat-free mass and muscle ...
Servings Per Container: 0 Pack contains 1 Herbatint Haircolour Gel 60ml, 1 Glycol Developer 60ml, 1 sample of either Royal Cream Conditioner or Shampoo 10ml, 1 pair gloves, 1 leaflet giving directions for use. Other Ingredients: Haircolor Gel: laureth-5, propylene glycol, water, peg-2 oleamine, ethanolamine, walnut extract, rhubarb extract, cinchona extract, aloe extract, meadowfoam extract, birch extract, cetrimonium chloride, echinacea augustifolia extract, hamamelis virginiana extract, sodium sulfite, ascorbic acid, tetrasodium edta, resorcinol, m-o-p aminophenol, 2 amino 3 hydroxypiridine, m-p phenylenediamine. Glycol Developer: water, hydrogen peroxide, etidronic acid, wild marjoram extract, thyme extract, cinnamon extract, rosemary extract, lavender extract, golden seal root extract, peg-40 hydrogenated castor oil, propylene glycol, simethicone. Royal Cream conditioner: water, mallow extracts, rosemary extract, behentrimonium chloride, wheat bran lipids, fragrance. Warnings This product ...
Follistatin on Monkeys. The researchers just injected the gene follistatin (FS344) directly into the monkeys right thigh muscles. It has been shown that follistatin can block myostatin, a molecule that down-regulates muscle growth, but strengthens tendons. Eight weeks after the injection the circumference of the monkeys right thigh muscles, had on average gone up 15 percent compared with the left thigh. A study done on two of the monkeys showed that muscle strength in the right leg was increased by respectively 12 and 36 per cent compared to the untreated leg.. SARM a potentially safer steroid. Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands. They are intended to have the same kind of effects as androgenic drugs like anabolic steroids but be much more selective in their action. None of the SARMs yet developed are truly selective for anabolic effects in muscle or bone tissues without producing any androgenic effects in tissues such as the prostate ...
Aqua/Water,Cetearyl Alcohol, Deceth-3, Propylene Glycol, Laureth-12, Ammonium Hydroxide, Oleth-30, Lauric Acid, Hexadimetherine Chloride, Glycol Distearate, Ethanolamine, Polyquarternium-22, Silicia Dimethyl Silylate, p-Phenylenediamine, CI 77891/Titanium Dioxide, 4-Amino-2-Hydroxytoluene, p-Aminophenol, Ascorbic Acid, Sodium Metabisulfite, 2-Methyl-5-Hydroxyethylaminophenol, Dimethicone, Pentasodium Pentetate, Carbomer, Resorcinol, Vitis Vinifera Seed Oil/Grape Seed Oil, Parfum/Fragrance (C35204/1 ...
Ten nonfluorescent Pseudomonas strains isolated from water-soaked lesions on cotyledons of plants of five Citrullus lanatus (watermelon) plant introductions were characterized and compared phenotypically with 22 other pseudomonads. The strains were distinguished phenotypically from other known plant pathogenic pseudomonads. The watermelon bacterium was aerobic. Cells were rod-shaped, gram negative, and motile by means of a single polar flagellum. They were nonfluorescent and grew at 41°C but not at 4°C. Oxidase production and the 2-ketogluconate reaction were positive. The 10 strains utilized β-alanine, L-leucine, D-serine, n-propanal, ethanol, ethanolamine, citrate, and fructose for growth. No growth occurred with sucrose or glucose. Their deoxyribonucleic acid base composition was 66 ± 1 mol% guanine plus cytosine. The bacterium is phenotypically similar to P. pseudoalcaligenes but differs from it in being pathogenic to watermelon, Cucumis melo (cantaloupe), Cucumis satiwus (cucumber), and
Discuss Anabolic Androgenic Steroids (AAS) and SARMS (Selective androgen receptor modulators). Sponsored by Puritysourcelabs.ru. Voted #1 Source Supplier by the EliteFitness.com Members!

3-Aminophenol sulfate (2:1) | C12H16N2O6S - PubChem3-Aminophenol sulfate (2:1) | C12H16N2O6S - PubChem

3-Aminophenol sulfate (2:1) , C12H16N2O6S , CID 163205 - structure, chemical names, physical and chemical properties, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/3-Aminophenol_sulfate__2_1_

China 2 Aminophenol, China 2 Aminophenol Manufacturers and Suppliers on Alibaba.comChina 2 Aminophenol, China 2 Aminophenol Manufacturers and Suppliers on Alibaba.com

China 2 Aminophenol Suppliers and Manufacturers Directory - Source a Large Selection of 2 Aminophenol Products at from China ... Tags: 2-aminophenol-4-sulfonamide , 98-32-8 , 2-aminophenol-4-sulfonamide 99% /cas: 98-32-8 Offer Them In Bulk ... Alibaba.com offers 248 2 aminophenol products. such as free samples. There are 248 2 aminophenol suppliers, mainly located in ... The top supplying country is China (Mainland), which supply 100% of 2 aminophenol respectively. aminophenol products are most ...
more infohttp://www.alibaba.com/countrysearch/CN/2-aminophenol.html

Nomination Summary for Salmonella assay for group of aminophenols (N82317)Nomination Summary for Salmonella assay for group of aminophenols (N82317)

3-Aminophenol, p-Aminophenol, 2-Amino-1-phenol-4-sulfonic acid, 3-Amino-5-sulfosalicylic acid, 5-Amino-3-sulfosalicylic acid, 2 ... Nomination Summary for Salmonella assay for group of aminophenols (N82317). Nomination Summary for Salmonella assay for group ... Nominated Substances: 2-Acetylamino-4-methylphenol, N-Acetyl-m-aminophenol, 5-(4-Aminobenzamido)-2,3-cresotic acid, 2-Amino-4- ...
more infohttps://ntp.niehs.nih.gov/testing/noms/search/summary/nm-n82317.html

N,O-DIACETYL-4-AMINOPHENOL (CAS 2623-33-8) Market Research Report 2018N,O-DIACETYL-4-AMINOPHENOL (CAS 2623-33-8) Market Research Report 2018

O-DIACETYL-4-AMINOPHENOL (CAS 2623-33-8) Market Research Report 2018 aims at providing comprehensive data on n,o-diacetyl-4- ... N,o-diacetyl-4-aminophenol market forecast. 6. N,O-DIACETYL-4-AMINOPHENOL MARKET PRICES. 6.1. N,o-diacetyl-4-aminophenol prices ... N,o-diacetyl-4-aminophenol prices in other regions. 7. N,O-DIACETYL-4-AMINOPHENOL END-USE SECTOR 7.1. N,o-diacetyl-4- ... 3. N,O-DIACETYL-4-AMINOPHENOL MANUFACTURING METHODS. 4. N,O-DIACETYL-4-AMINOPHENOL PATENTS. Abstract. Description. Summary of ...
more infohttps://marketpublishers.com/report/industry/chemicals_petrochemicals/cbindex_2623-33-8_market_research_report.html

Epoxy resin compositions from glycidyl derivatives of aminophenols cured     with tetracarboxylic dianhydrides - Patent #...Epoxy resin compositions from glycidyl derivatives of aminophenols cured with tetracarboxylic dianhydrides - Patent #...

... derivative of an aminophenol having the structure ##STR1## and at least one biphenyl anhydride having the structure ##STR2## ... The preferred polyglycidyl derivative of aminophenol at the present time is triglycidylp-aminophenol (m is 1).. The biphenyl ... An epoxy resin composition according to claim 18 wherein said polyglycidyl aminophenol is triglycidyl p-aminophenol.. 21. An ... An epoxy resin composition according to claim 24 wherein said polyglycidyl aminophenol is triglycidyl p-aminophenol.. 26. An ...
more infohttp://www.patentgenius.com/patent/4002599.html

Temperature and pH effects on the kinetics of 2-aminophenol auto-oxidation in aqueous solution - Open Chemistry - Tom 1, Numer...Temperature and pH effects on the kinetics of 2-aminophenol auto-oxidation in aqueous solution - Open Chemistry - Tom 1, Numer...

The kinetics of the auto-oxidation of 2-aminophenol (OAP) to 2-amino-phenoxazin-3-one (APX) was followed in air-saturated ... 19] J. Kaizer, R. Csonka, G. Speier: "TEMPO-initiated oxidation of 2-aminophenol to 2-aminophenoxazin-3-one", J. Mol. Cat., Vol ... 12] C.E. Barry, G.N. Parmesh, T.P. Begley: "Phenoxazinone synthase: enzymatic catalysis of an aminophenol oxidative cascade", J ... 17] L. Prati, M. Rossi, N. Ravasio: "Interaction of molecular oxygen with aminophenols mediated by copper metal and copper ...
more infohttp://yadda.icm.edu.pl/yadda/element/bwmeta1.element.-psjd-doi-10_2478_BF02476226

2-Aminophenol - DrugBank2-Aminophenol - DrugBank

aminophenol (CHEBI:18112) / a phenol (2-AMINOPHENOL) Targets. Details1. Nicotinate-nucleotide--dimethylbenzimidazole ... O-aminophenol / Aniline or substituted anilines / Aminophenol / 1-hydroxy-4-unsubstituted benzenoid / 1-hydroxy-2-unsubstituted ... 2-Aminophenol. PDB Entries. 1l4n. Clinical Trials. Clinical Trials Not Available. Pharmacoeconomics. Manufacturers. Not ... o-Aminophenols / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids / Primary amines / Organopnictogen ...
more infohttps://www.drugbank.ca/drugs/DB01726

O-aminophenolO-aminophenol

Browse fuzing.com to find O-aminophenol sellers, suppliers, wholesalers, companies, manufacturers, exporters, factories. ... O-aminophenol. You May Also Be Interested In: medicine packaging organic intermediate Appearance : nearly white powdered ...
more infohttps://www.fuzing.com/O-aminophenol/l/89302505-3251-f867-f2ec-6b09ddf7d578

Rapid Chemoselective Bioconjugation Through Oxidative Coupling of Anilines and AminophenolsRapid Chemoselective Bioconjugation Through Oxidative Coupling of Anilines and Aminophenols

Coupling of anilines to o-aminophenol groups derived from tyrosine residues is also described. The compatibility of this method ... A highly efficient protein bioconjugation method is described involving addition of anilines to o-aminophenols in the presence ... "Rapid Chemoselective Bioconjugation through Oxidative Coupling of Anilines and Aminophenols." Journal of the American Chemical ...
more infohttps://dash.harvard.edu/handle/1/33471164

N-Methyl-p-aminophenol sulfate | C14H20N2O6S - PubChemN-Methyl-p-aminophenol sulfate | C14H20N2O6S - PubChem

N-Methyl-p-aminophenol sulfate , C14H20N2O6S , CID 5930 - structure, chemical names, physical and chemical properties, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/Metol

Aminophenol - WikipediaAminophenol - Wikipedia

Aminophenol may refer to any of three isomeric chemical compounds: 2-Aminophenol 3-Aminophenol 4-Aminophenol They are ...
more infohttps://en.wikipedia.org/wiki/Aminophenol

United States 2-Aminophenol Market Report 2016 : ReportsnReportsUnited States 2-Aminophenol Market Report 2016 : ReportsnReports

Notes: Sales, means the sales volume of 2-Aminophenol Revenue,... ... Check for Discount on United States 2-Aminophenol Market Report ... 1 2-Aminophenol Overview. 1.1 Product Overview and Scope of 2-Aminophenol. 1.2 Classification of 2-Aminophenol. 1.2.1 Type I. ... 2.4 2-Aminophenol Market Competitive Situation and Trends. 2.4.1 2-Aminophenol Market Concentration Rate. 2.4.2 2-Aminophenol ... United States 2-Aminophenol Market Report 2016 Table of Contents. United States 2-Aminophenol Market Report 2016. ...
more infohttp://www.reportsnreports.com/reports/759926-united-states-2-aminophenol-market-report-2016.html

3-Aminophenol - Wikipedia3-Aminophenol - Wikipedia

It is the meta isomer of 2-aminophenol and 4-aminophenol. 3-Aminophenol can be prepared by caustic fusion of 3- ... 3-Aminophenol is an organic compound with formula C6H4(NH2)(OH). It is an aromatic amine and aromatic alcohol. ... 3-Aminophenol at Sigma-Aldrich. Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book ... Locants 2, 3, and 4 are recommended, not o, m, and p. Mitchell, Stephen C.; Waring, Rosemary H. (2000). "Aminophenols". ...
more infohttps://en.wikipedia.org/wiki/3-Aminophenol

Sequence Similarity 









- 1L4N: Crystal Structure of CobT complexed with 2-aminophenol Sequence Similarity Report PageSequence Similarity - 1L4N: Crystal Structure of CobT complexed with 2-aminophenol Sequence Similarity Report Page

1L4N: Structural studies of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica: the apo, substrate, and product-aldimine complexes.
more infohttp://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1L4N&

Specific Chemical Reactivities of Spatially Separated 3-Aminophenol Conformers with Cold Ca+ Ions | ScienceSpecific Chemical Reactivities of Spatially Separated 3-Aminophenol Conformers with Cold Ca+ Ions | Science

Specific Chemical Reactivities of Spatially Separated 3-Aminophenol Conformers with Cold Ca+ Ions ... Specific Chemical Reactivities of Spatially Separated 3-Aminophenol Conformers with Cold Ca+ Ions ... Specific Chemical Reactivities of Spatially Separated 3-Aminophenol Conformers with Cold Ca+ Ions ... Specific Chemical Reactivities of Spatially Separated 3-Aminophenol Conformers with Cold Ca+ Ions ...
more infohttp://science.sciencemag.org/content/342/6154/98.summary?rss=1

CAS 591-27-5 3-Aminophenol Properties,manufacturers,suppliers,fob priceCAS 591-27-5 3-Aminophenol Properties,manufacturers,suppliers,fob price

Find quality 3-Aminophenol CAS:591-27-5 manufacturers, suppliers, exporters, importers, buyers, wholesalers,producers start ... Provide the most valuable information resources about 3-Aminophenol,CAS 591-27-5,Molecular Formula C6H7NO,structure, ... HYDROXYBENZENE 3-AMINOPHENOL 3-HYDROXYANILINE 5-AMINO-PHENOL AMINOPHENOL-3 LABOTEST-BB LTBB000485 M-AMINOPHENOL META AMINO ... DetailDesc: m-Amino phenol Name:m-Aminophenol Synonym: C.I. 76545 C.I. OXIDATION BASE 7 3-AMINO-1-HYDROXYBENZENE M- ...
more infohttp://www.guidechem.com/cas-591/591-27-5.html

Molbank | Free Full-Text | 3-({5-Bromo-4-[pyrrolidin-1-yl]pyrimidin-2-yl}amino)phenolMolbank | Free Full-Text | 3-({5-Bromo-4-[pyrrolidin-1-yl]pyrimidin-2-yl}amino)phenol

3-({5-Bromo-4-[pyrrolidin-1-yl]pyrimidin-2-yl}amino)phenol by Alan M. Jones ... Jones, A.M. 3-({5-Bromo-4-[pyrrolidin-1-yl]pyrimidin-2-yl}amino)phenol. Molbank 2015, 2015, M859. ... "3-({5-Bromo-4-[pyrrolidin-1-yl]pyrimidin-2-yl}amino)phenol." Molbank 2015, no. 2: M859. ... 3-({5-Bromo-4-[pyrrolidin-1-yl]pyrimidin-2-yl}amino)phenol. Molbank. 2015; 2015(2):M859. ...
more infohttps://www.mdpi.com/1422-8599/2015/2/M859

IDEALS @ Illinois: Ir-driven Dynamics Of The 3-aminophenol-ammonia ComplexIDEALS @ Illinois: Ir-driven Dynamics Of The 3-aminophenol-ammonia Complex

Merrill, W.G.; Crim, F.; Case, A.; Heid, C.G. IR-DRIVEN DYNAMICS OF THE 3-AMINOPHENOL-AMMONIA COMPLEX. Proceedings of the ... We report on gas-phase experiments investigating the predissociation and possible IR-driven isomerization of the 3-aminophenol- ... Ir-driven Dynamics Of The 3-aminophenol-ammonia Complex. Welcome to the IDEALS Repository. ... Ir-driven Dynamics Of The 3-aminophenol-ammonia Complex. Merrill, W G ...
more infohttps://www.ideals.illinois.edu/handle/2142/50869

NOPR: Syntheses and dyeing characteristics of arylene bisazo 3-aminophenols and their polycondensates with formaldehydeNOPR: Syntheses and dyeing characteristics of arylene bisazo 3-aminophenols and their polycondensates with formaldehyde

Five arylene bisazo 3-aminophenols (IVa-e) and their corresponding polycondensates with formaldehyde (Va-e) were prepared and ... Syntheses and dyeing characteristics of arylene bisazo 3-aminophenols and their polycondensates with formaldehyde. ...
more infohttp://nopr.niscair.res.in/handle/123456789/32310

US3615498A - Color developers containing substituted nbenzyl-p-aminophenol competing developing agents 
      - Google PatentsUS3615498A - Color developers containing substituted nbenzyl-p-aminophenol competing developing agents - Google Patents

l N-benzyl-p-aminophenol hydrochloride 0.85 Cyan Color Developer 2 N-piperonyl-p-aminophenol hydrochloride 0 R5 50 3 6-(p- ... N-piperonyl-p-aminophenol EXAMPLE 1 A multilayer color photographic film was formed of the following layers (in the order given ... v Reproduced N0 Compensating developer (AP (3) l N-benzyl-p-aminophenol 1.05 0.63 l 5 g ig; 2 1.05 1.13 1.15 0.32 0.30 2 6-(p- ... N-benzyl-p-aminophenol is widely used as one such compensating developer. It is generally known that the compensating ...
more infohttps://patents.google.com/patent/US3615498A/en

Global Para Amino Phenol Industry 2015 Market Survey Study Analysis and Overview | Mar 4, 2015 - ReleaseWireGlobal Para Amino Phenol Industry 2015 Market Survey Study Analysis and Overview | Mar 4, 2015 - ReleaseWire

1.4 Para Amino Phenol Industry Overview. Chapter Two Para Amino Phenol International and China Market Analysis. 2.1 Para Amino ... Chapter One Para Amino Phenol Industry Overview. 1.1 Para Amino Phenol Definition. 1.2 Para Amino Phenol Classification and ... 5.1 Para Amino Phenol Product Specifications. 5.2 Para Amino Phenol Manufacturing Process Analysis. 5.3 Para Amino Phenol Cost ... 2.2.5 Para Amino Phenol China Market Development Trend. 2.2.6 China Para Amino Phenol New Project and Project Plan. 2.3 Para ...
more infohttp://www.sbwire.com/press-releases/release-584441.htm

EMEA (Europe, Middle East and Africa) Para Amino Phenol (PAP) Market Report 2017 - QY ResearchEMEA (Europe, Middle East and Africa) Para Amino Phenol (PAP) Market Report 2017 - QY Research

Table EMEA Para Amino Phenol (PAP) Sale Price (USD/MT) by Type (2012-2017). Table EMEA Para Amino Phenol (PAP) Sales (K MT) and ... Table EMEA Para Amino Phenol (PAP) Sale Price (USD/MT) by Players (2012-2017). Table EMEA Para Amino Phenol (PAP) Sales (K MT) ... Figure France Para Amino Phenol (PAP) Sales (K MT) and Growth Rate (2012-2017). Figure UK Para Amino Phenol (PAP) Sales (K MT) ... Figure UAE Para Amino Phenol (PAP) Sales (K MT) and Growth Rate (2012-2017). Figure Iran Para Amino Phenol (PAP) Sales (K MT) ...
more infohttps://www.qyresearchreports.com/report/emea-europe-middle-east-and-africa-para-amino-phenol-pap-market-report-2017.htm

Protein modification with o-aminophenols. (a)The N-term | Open-iProtein modification with o-aminophenols. (a)The N-term | Open-i

a)The N-terminus of several proteins was PEGylated using o-aminophenol-functionalized 5 kDa PEG and ferricyanide. (b) ... fig3: Protein modification with o-aminophenols. (a)The N-terminus of several proteins was PEGylated using o-aminophenol- ... fig3: Protein modification with o-aminophenols. (a)The N-terminus of several proteins was PEGylated using o-aminophenol- ... b) Modificationof wild type proteins with 5 kDa o-aminophenol-PEGwas monitored by SDS-PAGE. The products appear as higher MW ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4353012_ja-2014-00728c_0008&req=4

Synthesis and electrochromic properties of poly-o-aminophenol | ScholarBank@NUSSynthesis and electrochromic properties of poly-o-aminophenol | [email protected]

Zhang, A.Q.,Cui, C.Q.,Chen, Y.Z.,Lee, J.Y. (1994-08-08). Synthesis and electrochromic properties of poly-o-aminophenol. Journal ... The electropolymerization of o-aminophenol is markedly different from that of aniline and other aniline derivatives owing to ... The growth of poly-o-aminophenol (POAP) therefore proceeds mainly through the reactions between the growing polymer and ...
more infohttp://scholarbank.nus.edu.sg/handle/10635/67573
  • 3-Aminophenol has been used as a stabilizer of chlorine-containing thermoplastics, although its principal use is as an intermediate in the production of 4-amino-2-hydroxybenzoic acid this isomer is also employed as a hair colorant and as a coupler molecule in hair dyes. (guidechem.com)
  • A highly efficient protein bioconjugation method is described involving addition of anilines to o-aminophenols in the presence of sodium periodate. (harvard.edu)
  • Protein modification with o-aminophenols. (nih.gov)
  • A number of reports indicate that 4-aminophenol might be a key intermediate in the biodegradation of nitrobenzenes and amines ( 7 , 19 , 25 ). (asm.org)
  • 3-Aminophenol can be prepared by caustic fusion of 3-aminobenzenesulfonic acid (i.e. heating with NaOH to 245 °C for 6 hours) or from resorcinol via a substitution reaction with ammonium hydroxide. (wikipedia.org)
  • Several proteins werereacted with o-aminophenol-functionalized 5 kDa PEGunder the optimized reaction conditions (Figure 3). (nih.gov)
  • b) Modificationof wild type proteins with 5 kDa o-aminophenol-PEGwas monitored by SDS-PAGE. (nih.gov)
  • Only at basic pH in the presence of both the o-aminophenol substrate and the oxidant was modification observed.Additionally, the proline-terminal variant showed significantly improvedreactivity compared to that of the wild-type N-terminus. (nih.gov)
  • Guliev, A. 2013-12-28 00:00:00 Polyconjugated oligomers containing aromatic links with hydroxyl and amino functional groups were synthesized by oxidative polycondensation of 4-aminophenol. (deepdyve.com)