A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.
Amino-substituted glyoxylic acid derivative.
An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19.
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Condensation products of aromatic amines and aldehydes forming azomethines substituted on the N atom, containing the general formula R-N:CHR. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.
Respirators to protect individuals from breathing air contaminated with harmful dusts, fogs, fumes, mists, gases, smokes, sprays, or vapors.
Using ice skates, roller skates, or skateboards in racing or other competition or for recreation.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Clothing designed to protect the individual against possible exposure to known hazards.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.
Sulfonic acid derivatives that are substituted with an aliphatic hydrocarbon group.
Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.
Organic esters or salts of sulfonic acid derivatives containing an aliphatic hydrocarbon radical.
Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)
The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.
Detailed account or statement or formal record of data resulting from empirical inquiry.
Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The circulation or wide dispersal of information.
The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Epithelial cell line originally derived from porcine kidneys. It is used for pharmacologic and metabolic studies.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Established cell cultures that have the potential to propagate indefinitely.
The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.
A cell line derived from cultured tumor cells.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.
The initial stages of the growth of SEEDS into a SEEDLINGS. The embryonic shoot (plumule) and embryonic PLANT ROOTS (radicle) emerge and grow upwards and downwards respectively. Food reserves for germination come from endosperm tissue within the seed and/or from the seed leaves (COTYLEDON). (Concise Dictionary of Biology, 1990)
Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.
The state of failure to initiate and complete the process of growth, reproduction, or gemination of otherwise normal plants or vegetative structures thereof.
Derivatives of ethylene, a simple organic gas of biological origin with many industrial and biological use.
The study of the origin, structure, development, growth, function, genetics, and reproduction of plants.
A plant species of the genus LEPIDIUM, family BRASSICACEAE that is a fast-growing, often weedy native of western Asia. It is widely grown, especially in its curl-leaved form, and used as a garnish
Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.
A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Habitat of hot water naturally heated by underlying geologic processes. Surface hot springs have been used for BALNEOLOGY. Underwater hot springs are called HYDROTHERMAL VENTS.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats. (1/114)

cis-3-(9H-Purin-6-ylthio)acrylic acid (PTA) is a structural analog of azathioprine, a prodrug of the antitumor and immunosuppressive drug 6-mercaptopurine (6-MP). In this study, we examined the in vitro and in vivo metabolism of PTA in rats. Two metabolites of PTA, 6-MP and the major metabolite, S-(9H-purin-6-yl)glutathione (PG), were formed in a time- and GSH-dependent manner in vitro. Formation of 6-MP and PG occurred nonenzymatically, but 6-MP formation was enhanced 2- and 7-fold by the addition of liver and kidney homogenates, respectively. Purified rat liver glutathione S-transferases enhanced 6-MP formation from PTA by 1.8-fold, whereas human recombinant alpha, mu, and pi isozymes enhanced 6-MP formation by 1.7-, 1.3-, and 1.3-fold, respectively. In kidney homogenate incubations, PG accumulation was only observed during the first 15 min because of further metabolism by gamma-glutamyltranspeptidase, dipeptidase, and beta-lyase to yield 6-MP, as indicated by the use of the inhibitors acivicin and aminooxyacetic acid. Based on these results and other lines of evidence, two different GSH-dependent pathways are proposed for 6-MP formation: an indirect pathway involving PG formation and further metabolism to 6-MP, and a direct pathway in which PTA acts as a Michael acceptor. HPLC analyses of urine of rats treated i.p. with PTA (100 mg/kg) showed that 6-MP was formed in vivo and excreted in urine without apparent liver or kidney toxicity. Collectively, these studies show that PTA is metabolized to 6-MP both in vitro and in vivo and may therefore be a useful prodrug of 6-MP.  (+info)

GABA agonists differentially modify blood glucose levels of diabetic rats. (2/114)

This study described the effects of GABA agonists on glucose plasma concentrations of streptozotocin-induced diabetic rats. Low doses of an indirect GABA agonist, AOAA (aminooxyacetic acid); a GABA(A) and a GABA(B) agent, THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridone) and baclofen, respectively; and a benzodiazepine were administered to non-diabetic and to diabetic rats. Plasma glucose concentrations were estimated during fasting and after an oral glucose load. Diazepam (1 mg/kg), baclofen (1 mg/kg) and AOAA (30 mg/kg), significantly decreased glycemia after oral glucose overload of streptozotocin-induced diabetes. None of the GABA-acting agents tested changed fasting or glucose overload glycemia of normal rats. Diazepam was the only drug to increase the fasting blood glucose concentration of diabetic rats. Treatment with AOAA or diazepam was accompanied by increased insulin plasma concentrations in diabetic rats to levels similar to the ones of non-diabetic animals. These results demonstrate that benzodiazepines and other GABA drugs act the endocrine pancreas in vivo, ultimately increasing plasma insulin and decreasing high blood glucose levels of diabetic rats. The acute and prolonged effects of the multitude of drugs acting on the GABA(A)-benzodiazepine-chloride ionophore complex remain to be broadly investigated as a therapeutic tool in diabetes.  (+info)

Beta-cyanoalanine synthase: purification and characterization. (3/114)

Beta-cyano-L-alanine synthase [L-cysteine hydrogen-sulfide-lyase (adding HCN), EC 4.4.1.9] was purified about 4000-fold from blue lupine seedlings. The enzyme was homoegeneous on gel electrophoresis and free of contamination by other pyridoxal-P-dependent lyases. The enzyme has a molecular weight of 52,000 and contains 1 mole of pyridoxal-P per mole of protein; its isoelectric point is situated at pH 4.7. Its absorption spectrum has two maxima, at 280 and 410 nm. L-Cysteine is the natural primary (amino acid) substrate; beta-chloro- and beta-thiocyano can serve (with considerably lower affinity) instead of cyanide as cosubstrates for cyanoalanine synthase. The synthase is refractory to DL-cycloserine and D-penicillamine, potent inhibitors of many pyridoxal-P-dependent enzymes. Cyanoalanine synthase catalyzes slow isotopic alpha-H exchange in cysteine and in end-product amino acids; the rates of alpha-H exchange in nonreacted (excess) cysteine are markedly increased in the presence of an adequate cosubstrate; no exchange is observed of H atoms in beta-position.  (+info)

The oscillatory behavior of pancreatic islets from mice with mitochondrial glycerol-3-phosphate dehydrogenase knockout. (4/114)

Glucose stimulation of pancreatic beta cells induces oscillations of the membrane potential, cytosolic Ca(2+) ([Ca(2+)](i)), and insulin secretion. Each of these events depends on glucose metabolism. Both intrinsic oscillations of metabolism and repetitive activation of mitochondrial dehydrogenases by Ca(2+) have been suggested to be decisive for this oscillatory behavior. Among these dehydrogenases, mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), the key enzyme of the glycerol phosphate NADH shuttle, is activated by cytosolic [Ca(2+)](i). In the present study, we compared different types of oscillations in beta cells from wild-type and mGPDH(-/-) mice. In clusters of 5-30 islet cells and in intact islets, 15 mM glucose induced an initial drop of [Ca(2+)](i), followed by an increase in three phases: a marked initial rise, a partial decrease with rapid oscillations and eventually large and slow oscillations. These changes, in particular the frequency of the oscillations and the magnitude of the [Ca(2+)] rise, were similar in wild-type and mGPDH(-/-) mice. Glucose-induced electrical activity (oscillations of the membrane potential with bursts of action potentials) was not altered in mGPDH(-/-) beta cells. In single islets from either type of mouse, insulin secretion strictly followed the changes in [Ca(2+)](i) during imposed oscillations induced by pulses of high K(+) or glucose and during the biphasic elevation induced by sustained stimulation with glucose. An imposed and controlled rise of [Ca(2+)](i) in beta cells similarly increased NAD(P)H fluorescence in control and mGDPH(-/-) islets. Inhibition of the malate-aspartate NADH shuttle with aminooxyacetate only had minor effects in control islets but abolished the electrical, [Ca(2+)](i) and secretory responses in mGPDH(-/-) islets. The results show that the two distinct NADH shuttles play an important but at least partially redundant role in glucose-induced insulin secretion. The oscillatory behavior of beta cells does not depend on the functioning of mGPDH and on metabolic oscillations that would be generated by cyclic activation of this enzyme by Ca(2+).  (+info)

Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells. (5/114)

Trichloroethylene (Tri) caused modest cytotoxicity in freshly isolated human proximal tubular (hPT) cells, as assessed by significant decreases in lactate dehydrogenase (LDH) activity after 1 h of exposure to 500 microM Tri. Oxidative metabolism of Tri by cytochrome P-450 to form chloral hydrate (CH) was only detectable in kidney microsomes from one patient out of four tested and was not detected in hPT cells. In contrast, GSH conjugation of Tri was detected in cells from every patient tested. The kinetics of Tri metabolism to its GSH conjugate S-(1,2-dichlorovinyl)glutathione (DCVG) followed biphasic kinetics, with apparent Km and Vmax values of 0.51 and 24.9 mM and 0.10 and 1.0 nmol/min per mg protein, respectively. S-(1,2-dichlorovinyl)-L-cysteine (DCVC), the cysteine conjugate metabolite of Tri that is considered the penultimate nephrotoxic species, caused both time- and concentration-dependent increases in LDH release in freshly isolated hPT cells. Preincubation of hPT cells with 0.1 mM aminooxyacetic acid did not protect hPT cells from DCVC-induced cellular injury, suggesting that another enzyme besides the cysteine conjugate beta-lyase may be important in DCVC bioactivation. This study is the first to measure the cytotoxicity and metabolism of Tri and DCVC in freshly isolated cells from the human kidney. These data indicate that the pathway involved in the cytotoxicity and metabolism of Tri in hPT cells is the GSH conjugation pathway and that the cytochrome P-450-dependent pathway has little direct role in renal Tri metabolism in humans.  (+info)

The effect of culture age, chloramphenicol and B6 inhibitors on intra- and extracellular keto and amino acids of Escherichia coli B. (6/114)

Keto acids and free amino acids were assayed in the cells and the medium of Escherichia coli B growing in the presence of chloramphenicol, cycloserines, aminooxyacetate, and limiting nitrogen source. Under these growth-limiting conditions the cells accumulated ketoglutarate and 'ketovaline' but no other keto acids. In all experiments only ketoglutarate, pyruvate, and 'ketovaline' were found in the medium. Amino acids are released into the medium in the early phases of growth and the composition of the extracellular amino acids is similar to that of the amino acid pool. The concentrations of free amino acids were 10-3-10-4 times higher in the cell than in the medium. The internal pool composition is fixed under all growth-limiting conditions. In the presence of the drugs the cells release amino acids into the medium.  (+info)

Use of sulfhydryl reagents to investigate branched chain alpha-keto acid transport in mitochondria. (7/114)

The goal of this paper was to determine the contribution of the mitochondrial branched chain aminotransferase (BCATm) to branched chain alpha-keto acid transport within rat heart mitochondria. Isolated heart mitochondria were treated with sulfhydryl reagents of varying permeability, and the data suggest that essential cysteine residues in BCATm are accessible from the cytosolic face of the inner membrane. Treatment with 15 nmol/mg N-ethylmaleimide (NEM) inhibited initial rates of alpha-ketoisocaproate (KIC) uptake in reconstituted mitochondrial detergent extracts by 70% and in the intact organelle by 50%. KIC protected against inhibition suggesting that NEM labeled a cysteine residue that is inaccessible when substrate is bound to the enzyme. Additionally, the apparent mitochondrial equilibrium KIC concentration was decreased 50-60% after NEM labeling, and this difference could not be attributed to effects of NEM on matrix pH or KIC oxidation. In fact, NEM was a better inhibitor of KIC oxidation than rotenone. Measuring matrix aspartate and glutamate levels revealed that the effects of NEM on the steady-state KIC concentration resulted from inhibition of BCATm catalyzed transamination of KIC with matrix glutamate to form leucine. Furthermore, circular dichroism spectra of recombinant human BCATm with liposomes showed that the commercial lipids used in the reconstituted transport assay contain BCAT amino acid substrates. Thus BCATm is distinct from the branched chain alpha-keto acid carrier but may interact with the inner mitochondrial membrane, and it is necessary to inhibit or remove transaminase activity in both intact and reconstituted systems prior to quantifying transport of alpha-keto acids which are transaminase substrates.  (+info)

Contribution of glutamate dehydrogenase to mitochondrial glutamate metabolism studied by (13)C and (31)P nuclear magnetic resonance. (8/114)

The relative contribution of glutamate dehydrogenase (GDH) and the aminotransferase activity to mitochondrial glutamate metabolism was investigated in dilute suspensions of purified mitochondria from potato (Solanum tuberosum) tubers. Measurements of glutamate-dependent oxygen consumption by mitochondria in different metabolic states were complemented by novel in situ NMR assays of specific enzymes that metabolize glutamate. First, a new assay for aminotransferase activity, based on the exchange of deuterium between deuterated water and glutamate, provided a method for establishing the effectiveness of the aminotransferase inhibitor amino-oxyacetate in situ, and thus allowed the contribution of the aminotransferase activity to glutamate oxidation to be assessed unambiguously. Secondly, the activity of GDH in the mitochondria was monitored in a coupled assay in which glutamine synthetase was used to trap the ammonium released by the oxidative deamination of glutamate. Thirdly, the reversibility of the GDH reaction was investigated by monitoring the isotopic exchange between glutamate and [(15)N]ammonium. These novel approaches show that the oxidative deamination of glutamate can make a significant contribution to mitochondrial glutamate metabolism and that GDH can support the aminotransferases in funneling carbon from glutamate into the TCA cycle.  (+info)

Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. Subsequently, the level of GABA is increased in tissues. At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. Aminooxyacetic acid is a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes. Aminooxyacetic acid inhibits aspartate aminotransferase, another PLP-dependent enzyme, which is an essential part of the malate-aspartate shuttle. The inhibition of the malate-aspartate shuttle prevents the reoxidation of cytosolic NADH by the mitochondria in nerve terminals. Also in the nerve terminals, ...
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam ...
Background: H2S is a neuromodulator that may inhibit intestinal motility. H2S production in colon is yielded by cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) enzymes and sulfate-reducing bacteria (SRB). Toll-like receptors (TLRs) recognize intestinal microbiota. The aim of this work was to evaluate the influence of TLR2 and TLR4 on the endogenous and SRB-mediated synthesis of H2S and its consequences on the colonic motility of mouse. Methods: Muscle contractility studies were performed in colon from WT, Tlr2-/-, and Tlr4-/- mice. The mRNA levels of TLR2, TLR4, CBS, CSE, and SRB were measured by real-time PCR. Free sulfide levels in colon and feces were determined by colorimetric assays. Results: NaHS and GYY4137, donors of H2S, reduced the contractility of colon. Aminooxyacetic acid (AOAA), inhibitor of CBS, and D-L propargylglycine (PAG), inhibitor of CSE, increased the contractility of colon. In vivo treatment with NaHS or GYY4137 inhibited the spontaneous contractions and ...
The authors claim in the results section of the abstract that probenecid diminished (P , 0.05) compound A-induced glucosuria. Figure 3, however, shows that there was no statistical significance assigned to this effect. The authors state that aminooxyacetic acid decreased compound A-dependent proteinuria and glucosuria; yet Figure 4shows that these decreases were not statistically significant, a further finding that is not consistent with compound A-induced nephrotoxicity being mediated by the renal cysteine conjugate [small beta, Greek]-lyase pathway of metabolism. Moreover, the authors purport that aminobenzotriazole had no consistent effect on the nephrotoxicity of compound A, which seems to suggest that the cytochrome P450 metabolism of compound A or its metabolites, or both, does not have a role in compound A-induced nephrotoxicity. Nevertheless, the manuscript actually shows that the preadministration of this cytochrome P450 inhibitor significantly decreased the histologic necrosis ...
1. Rat kidney-cortex slices incubated with d-malate alone formed very little glucose. d-Malate, however, augmented gluconeogenesis from l-lactate and inhibited gluconeogenesis from pyruvate and l-malate. 2. d-Malate had little effect on the rate of the tricarboxylic acid cycle with or without other substrates added. 3. d-Malate inhibited the activity of the l-malate dehydrogenase in a high-speed-supernatant fraction from kidney cortex. 4. It was concluded that d-malate inhibited either the operation of the cytoplasmic l-malate dehydrogenase or malate outflow from the mitochondria in the intact kidney-cortex cell. This supports the hypothesis of Lardy, Paetkau & Walter (1965) and Krebs, Gascoyne & Notton (1967) on the role of malate as carrier for carbon and reducing equivalents in gluconeogenesis. 5. Gluconeogenesis from l-lactate in kidney-cortex slices was strongly inhibited by a low concentration (0.1mm) of amino-oxyacetate, whereas glucose formation from pyruvate, malate, aspartate and ...
Purpose: Glutamine addiction in c-MYC-overexpressing breast cancer is targeted by the aminotransferase inhibitor, aminooxyacetate (AOA). However, the mechanism of ensuing cell death remains unresolved.. Experimental Design: A correlation between glutamine dependence for growth and c-MYC expression was studied in breast cancer cell lines. The cytotoxic effects of AOA, its correlation with high c-MYC expression, and effects on enzymes in the glutaminolytic pathway were investigated. AOA-induced cell death was assessed by measuring changes in metabolite levels by magnetic resonance spectroscopy (MRS), the effects of amino acid depletion on nucleotide synthesis by cell-cycle and bromodeoxyuridine (BrdUrd) uptake analysis, and activation of the endoplasmic reticulum (ER) stress-mediated pathway. Antitumor effects of AOA with or without common chemotherapies were determined in breast cancer xenografts in immunodeficient mice and in a transgenic MMTV-rTtA-TetO-myc mouse mammary tumor model.. Results: ...
In this study aminotransferase inhibitors were used to determine the relative importance of different aminotransferases in providing nitrogen for de novo glutamate synthesis in the retina. Aminooxyacetate, which inhibits all aminotransferases, blocke
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The oxidation of L-glutamate and L-glutamine by enterocyte mitochondria was supported by malate. The stimulation of the rate of oxidation of the two amino acids by small amounts of added malate was 93% and 76% respectively. This could not be accounted for by the oxidation of the small amounts of malate added. Amino-oxyacetate added initially inhibited malate-supported oxidation of L-glutamate by 81% and that of L-glutamine by 38%. The inhibition of L-glutamate oxidation was partially reversed by L-glutamine. The dicarboxylate-carrier inhibitor 2-phenylsuccinate inhibited the malate-supported oxidation of both amino acids, but appeared to be slightly stimulatory to L-glutamine oxidation when added initially. The inhibition of L-glutamate oxidation was reversed by L-glutamine. The mitochondrial uncoupler FCCP (carbonyl cyanide p-trifluoromethoxyphenylhydrazone) inhibited malate-supported oxidation of L-glutamate by 78% when added initially. The oxidation of L-glutamine was completely inhibited. ...
Eboli, M L.; Paradies, G; and Papa, S, Transport of anionic substrates and glutamate metabolism in mitochondria from ascites tumor cells. (1976). Subject Strain Bibliography 1976. 2337 ...
Als verantwortungsbewusster Inverkehrbringer der NADH - Produkte nach der orginalen Formulierung arbeiten die Prof. Birkmayer Laboratorien eng mit renommierten Experten der Rechtswissenschaften sowie aus dem Bereich der Life Science zusammen ...
We often focus on the problem of addiction more than the results of successful recovery. True, sobriety is a wonderful transformation characteristic of the beauty of humanity. However, the challenge of achieving long-term sobriety can seem unbelievable to those who suffer from addiction.
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April 2003Employees of Canadian airline WestJet Airlines contacted us when they learned, just two days in advance, that the company planned to
Similar to AOA treatment, knocking down GOT2 could also effectively inhibit the malate-aspartate shuttle, resulting in a significant increase (by 1.3‐fold; P , 0.01) in the cytosolic NADH level in Panc‐1 cells (Supplementary Fig S8A). Concomitantly, GOT2 knockdown led to a substantial reduction in the mitochondrial NADH level (by 33%; P , 0.01) (Supplementary Fig S8B), affirming the vital role of GOT2 in controlling the net transfer of cytosolic NADH into mitochondria. As a result, GOT2 knockdown significantly reduced ATP production (by 26%; P , 0.01) in Panc‐1 cells (Supplementary Fig S8C). Moreover, in these stable Panc‐1 cells with GOT2 knockdown, we found that re‐expression of acetylation‐mimetic 3KQ mutant GOT2 led to a significant (P , 0.05) reduction in the cytosolic NADH level as compared to wild‐type‐rescued cells when treated without or with glucose (i.e., 0 and 12 mM glucose) (Fig 4B). Meanwhile, 3KQ mutant GOT2‐rescued cells displayed a significant (P , 0.05 or P , ...
The lozalojo/mem package contains the following man pages: add.alpha calcular.indicadores calcular.indicadores.2.timings calcular.map calcular.optimo calcular.optimo.criterio calcular.optimo.derivada calcular.optimo.original calcular.optimo.pendiente comparar.metodos epimem epitiming extraer.datos.curva.map extraer.datos.epi extraer.datos.optimo.map extraer.datos.post.epi extraer.datos.pre.epi fill.missing flucyl flucylraw full.series.graph iconfianza iconfianza.aritmetica iconfianza.completo iconfianza.geometrica iconfianza.logx iconfianza.percentil.boot iconfianza.percentil.kc iconfianza.x max.fix.na max.n.valores memevolution memgoodness memintensity memmodel mem-package memstability memsurveillance memsurveillance.animated memtiming memtrend min.fix.na min.n.valores missings.inside normalizar optimal.tickmarks optimum.by.inspection output.ci processPlots roc.analysis semana.absoluta suavizado transformdata transformdata.back transformseries transformseries.odd transformseries.twowaves
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The activity of malate-aspartate shuttle is modulated by arginine methylation of Malate dehydrogenase 1 (MDH1). Protein arginine N-methyltransferase CARM1 methylates and inhibits MDH1 by disrupting its dimerization, which represses malate-aspartate shuttle and inhibits mitochondrial respiration of pancreatic cancer cells.. Contributed by: Soumya Khot ...
The European Space Agencys Envisat satellite, which bounces radar waves off the Yellowstone calderas floor, another way to measure elevation change.. The measurements showed that from mid-2004 through 2006, the Yellowstone caldera floor rose as fast as 2.8 inches (7 centimeters) per year - and by a total of 7 inches (18 centimeters) during the 30-month period, Chang says.. The uplift is still going on today but at a little slower rate, says Smith, adding there is no way to know when it will stop.. Smith says the fastest rate of uplift previously observed at Yellowstone was about 0.8 inch (2 centimeters) per year between 1976 and 1985. He says that Yellowstones recent upward motion may seem small, but is twice as fast as the average rate of horizontal movement along Californias San Andreas fault.. The current uplift is faster than ever observed at Yellowstone, but may not be the fastest ever, since humans werent around for its three supervolcano eruptions.. Chang, Smith and colleagues ...
0040]FIG. 6 is a flowchart of transmission timing adjustment processing according to the present embodiment. Reception timing detection unit 12 detects the reception timing of a received downlink radio frame (S100). Reception signal demodulation unit 14 demodulates the received signal (S101). If transmission timing information is included in the control signal, reception signal demodulation unit 14 sends the above transmission timing information to transmission timing adjustment unit 15. Transmission timing adjustment unit 15 decides the presence or absence of transmission timing information at each predetermined decision interval (S102). If the transmission timing information is sent, transmission timing adjustment unit 15 adjusts the transmission timing to a specified value included in the transmission timing information (S103). If the transmission timing information is not sent, transmission timing adjustment unit 15 decides whether the handover processing is in progress, based on the ...
Seven military conscripts from Dagestan landed in prison last year for forcing fellow sailors in the Baltic Fleet to spell out the word Caucasus with their bodies. The militarys top prosecutor warned in February that ethnic tensions were a main reason for hazing.
Studies on a 27-year-old man with a 3-year history of exercise-induced muscle pain, passage of red urine and elevated serum creatine kinase are described. Histological examination of a biopsy from quadriceps revealed non-specific myopathic changes with occasional clusters of subsarcolemmal mitochondria. The phosphorylase stain was normal. Phosphorous nuclear magnetic resonance (NMR) spectroscopy studies of gastrocnemius and flexor digitorum superficialis muscles showed no abnormalities at rest. During aerobic exercise there was an abnormally rapid decrease in phosphocreatine concentration but the pH remained within the normal range. There was a build-up of phosphomonoester (probably glucose 6-phosphate), usually indicative of a block in glycolysis. However, a primary defect in the glycolytic pathway seemed unlikely because muscle acidified normally during ischaemic exercise. Recovery from exercise was unusual in that phosphocreatine resynthesis and inorganic phosphate disappearance followed similar
Incretins, hormones released by the stomach after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. 1988; Porte, 1991) and is usually a target for its treatment. According to the consensus model of TBC-11251 glucose-induced insulin secretion (GIIS), GIIS depends on a series of cautiously orchestrated cell responses: mitochondrially generated ATP results in closure of ATP-sensitive K+ (KATP) channels, which in change causes membrane depolarization, electrical activity, and opening of voltage-dependent Ca2+ channels (VDCCs), with the resultant elevation of [Ca2+]i initiating Ca2+-induced insulin granule exocytosis (Henquin, 2000). Thus, ATP produced by glucose metabolism is usually a crucial transmission in GIIS. Pancreatic cells are equipped with two highly active NADH shuttles linked to glycolysis: the malate-aspartate shuttle and the glycerol phosphate shuttle, both of which contribute to ATP production. Whereas inhibition of either one ...
integral component of membrane, mitochondrial inner membrane, L-aspartate transmembrane transporter activity, L-glutamate transmembrane transporter activity, aspartate transport, L-glutamate transmembrane transport, malate-aspartate shuttle
Shuttle found in: HIROBO HELIS SHUTTLE PLUS 60 Econo Power Manufacturer/Model By Series, HIROBO HELIS SHUTTLE ZX Econo Power Manufacturer/Model By..
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The extremely halophilic archaeon Natrialba aegyptiaca secretes the L-homo type of poly-g-glutamate (PGA) as an extremolyte. We examined the enzymes involved in glutamate metabolism and verified the presence of L-glutamate dehydrogenases, L-aspartate aminotransferase, and L-glutamate synthase. However, neither glutamate racemase nor D-amino acid aminotransferase activity was detected, suggesting the absence of sources of D-glutamate. In contrast, D-glutamate-rich PGA producers mostly possess such intracellular sources of D-glutamate. The results of our present study indicate that the D-glutamate-anabolic enzyme
Glutamine and glutamate are known to play important roles in cancer biology. However, no detailed information is available in terms of their levels of involvement in various biological processes across different cancer types, whereas such knowledge could be critical for understanding the distinct characteristics of different cancer types. Our computational study aimed to examine the functional roles of glutamine and glutamate across different cancer types. We conducted a comparative analysis of gene expression data of cancer tissues versus normal control tissues of 11 cancer types to understand glutamine and glutamate metabolisms in cancer. Specifically, we developed a linear regression model to assess differential contributions by glutamine and/or glutamate to each of seven biological processes in cancer versus control tissues. While our computational predictions were consistent with some of the previous observations, multiple novel predictions were made: (1) glutamine is generally not involved in
View Notes - lecture14_10_21_08 from CHM 6620 at Wayne State University. Lecture 14 Overview: -glycolysis regulation -glucose synthesis -gluconeogenesis regulation Control of the glycolytic pathway
Aminoethoxyvinylglycine (AVG), Aminooxyacetic acid (AOA), and silver salts are ethylene inhibitors. Inhibiting ethylene ... Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme ... SAM is then converted to 1-aminocyclopropane-1-carboxylic acid (ACC) by the enzyme ACC synthase (ACS). The activity of ACS ... Smoke contains ethylene, and once this was realized the smoke was replaced with ethephon or naphthalene acetic acid, which ...
"Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals". Neuropharmacology. 10 (1): ... Sheng-Dun Lin, et al., Bioactive components and antioxidant properties of g-aminobutyric acid (GABA) tea leaves. LWT - Food ... began developing GABA-rich tea in 1984 and successfully produced a new type tea in which almost all glutamic acid has been ... Effect of green tea rich in gamma-aminobutyric acid on blood pressure of Dahl saltsensitive rats. Am J Hypertens. 1995, 8: 74- ...
Aminooxyacetic acid Gabaculine Phenelzine Phenylethylidenehydrazine (PEH) Rosmarinic acid Valproic acid Vigabatrin "4- ... As a transaminase, GABA-T's role is to move functional groups from an amino acid and a α-keto acid, and vice versa. In the case ... This succinate will then enter mitochondrion and become part of the citric acid cycle. The critic acid cycle can then produce 2 ... Amino acid residues found in the active site of 4-aminobutyrate transaminase include Lys-329, which are found on each of the ...
Inhibitors of the 4-aminobutyrate transaminase isoform include aminooxyacetic acid, gabaculine, phenelzine, ... phenylethylidenehydrazine (PEH), rosmarinic acid, valproic acid and vigabatrin. Some GABA transaminase inhibitors may be used ...
ACC Synthase is also competitively inhibited by aminoethoxyvinylglycine (AVG) and aminooxyacetic acid (AOA), inhibitors to many ... α-keto-γ-methylthiobutyric acid, and S-adenosylhomocysteine. ACC Synthase is 450-516 amino acid long sequence depending on the ... Aminocyclopropane-1-carboxylic acid synthase (ACC synthase, ACS) (EC 4.4.1.14) is an enzyme that catalyzes the synthesis of 1- ... 1-aminocyclopropane-1-carboxylic acid synthase, 1-aminocyclopropane-1-carboxylate synthetase, aminocyclopropanecarboxylic acid ...
Aminoethoxyvinylglycine (AVG), Aminooxyacetic acid (AOA), and silver salts are ethylene inhibitors.[44][45] Inhibiting ethylene ... Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol). *Unsorted benzodiazepine site positive ... Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme ... Ethylene appears to have been discovered by Johann Joachim Becher, who obtained it by heating ethanol with sulfuric acid;[48] ...
The molecular formula C2H5NO3 (molar mass: 91.066 g/mol, exact mass: 91.02694 u) may refer to: Aminooxyacetic acid (AOA or AOAA ...
Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated ... gamma-Aminobutyric acid, or γ-aminobutyric acid /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, or GABA /ˈɡæbə/, is the chief inhibitory ... Although in chemical terms, GABA is an amino acid (as it has both a primary amine and a carboxylic acid functional group), it ... By convention the term "amino acid", when used without a qualifier, refers specifically to an alpha amino acid. GABA is not an ...
Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-gamma-aminobutyric acid in normal and amino oxyacetic acid- ... gamma-Hydroxybutyric acid or γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring ... Beta-Hydroxybutyric acid γ-Hydroxyvaleric acid (GHV) γ-Valerolactone (GVL) Riviello, Ralph J. (2010). Manual of forensic ... May 2003). "A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand". ...
... aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. Aminooxyacetic acid is a general ... I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino- ... Also in 1936, Kitagawa and Takani described the preparation of aminooxyacetic acid by the condensation of benzhydroxamic acid ... and was prepared by the hydrolysis of ethylbenzhydroximinoacetic acid. In 1936, Anchel and Shoenheimer used aminooxyacetic acid ...
... aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. Aminooxyacetic acid is a general ... I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino- ... Also in 1936, Kitagawa and Takani described the preparation of aminooxyacetic acid by the condensation of benzhydroxamic acid ... and was prepared by the hydrolysis of ethylbenzhydroximinoacetic acid. In 1936, Anchel and Shoenheimer used aminooxyacetic acid ...
... thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem] ... Carboxylic acids. Direct Parent. Carboxylic acids. Alternative Parents. Monocarboxylic acids and derivatives / Organic oxides ... Aminooxyacetic_acid. PDB Entries. 1h0c / 1j04 / 1wyv. Clinical Trials. Clinical Trials Not Available. Pharmacoeconomics. ... Aminooxyacetic acid. Accession Number. DB02079 (EXPT00528) Type. Small Molecule. Groups. Experimental. Description. A compound ...
... oxyacetic acid , C18H14N2O4 , CID 53962608 - structure, chemical names, physical and chemical properties, classification, ...
... oxyacetic acid , C7H13NO5 , CID 107938017 - structure, chemical names, physical and chemical properties, classification, ...
... or aminooxyacetic acid (AOA) were added to banana culture medium. The highest numbers of shoots per explants shoot length and ... or aminooxyacetic acid (AOA) were added to banana culture medium. The highest numbers of shoots per explants shoot length and ... Effects of ethylene inhibitors, silver nitrate (AgNO3), cobalt chloride (CoCl2) and aminooxyacetic acid (AOA), on in vitro ...
... or aminooxyacetic acid (AOA) were added to banana culture medium. The highest numbers of shoots per explants shoot length and ... or aminooxyacetic acid (AOA) were added to banana culture medium. The highest numbers of shoots per explants shoot length and ... Effects of ethylene inhibitors, silver nitrate (AgNO3), cobalt chloride (CoCl2) and aminooxyacetic acid (AOA), on in vitro ... Satoh S,Esashi Y (1980). a-Aminoisobutyric acid: A probable competitive inhibitor of conversion of 1 -aminocyclo propane-1 - ...
Aminooxyacetic acid (АОА), inhibitor of 1-aminocyclopropane-1-carboxilic acid (AСС) synthesis, suppresses self-incompatibility- ... Wu L, Williams JS, Wang N, Khatri WA, San Román D, T-h K (2018) Use of domain-swapping to identify candidate amino acids ... Kovaleva LV, Zakharova EV, Voronkov AC, Timofeeva GV, Andreev IM (2017) Role of abscisic acid and ethylene in the control of ... found that preliminary treatment before self-pollination of stigmas of petunia self-incompatible line with aminooxyacetic acid ...
... acetic acid, 98% 1g Alfa Aesar™ Bis(Boc-aminooxy)acetic acid, 98% Monocarboxylic acids and derivatives ... 1-dimethylethoxy carbonyl amino oxy-acetic acid, bis-boc-aminooxyacetic acid, bis tert-butoxycarbonyl amino oxy acetic acid, ... 1-dimethylethoxy carbonyl amino oxy-acetic acid, bis-boc-aminooxyacetic acid, bis tert-butoxycarbonyl amino oxy acetic acid, ... bis-boc-amino-oxyacetic acid, bis-boc-aoa, bis 1,1-dimethylethoxy carbonyl amino oxy acetic acid, bis 1, ...
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam ...
US Patent for Amino thioxomethyl amino oxyacetic acid derivatives Patent (Patent # 6,472,430) Amino thioxomethyl amino ... N-methyl Aminooxy Acetic Acid Hydrochloride (5, R1=Me). A mixture of ethyl N-methyl N-ethoxy carbonyl aminooxy acetate ( ... A solution of N-methyl aminooxy acetic acid hydrochloride (9.5 g) in ethanol (100 mL) was saturated with hydrogen chloride. The ... This invention specifically relates to amino thioxomethyl amino oxyacetic acid derivatives that elevate HDL cholesterol ...
Alcoholism , Aminooxyacetic Acid , Animals , Hippocampus , Learning , Male , Maze Learning , Memory , Rats , Rats, Sprague- ... Effects of aminooxyacetic acid on the learning and memory ability and its possible mechanism in rats with chronic alcoholism / ... Effects of aminooxyacetic acid on the learning and memory ability and its possible mechani ... [email protected]#To investigate the effects of aminooxyacetic acid (AOAA) on learning and memory ability and possible mechanisms in ...
... clonazepam with amino-oxyacetic acid again Synergistic anticonvulsant action of diazepam & clonazepam with amino-oxyacetic acid ... butyric acid (GABA) transaminase inhibitor viz., aminooxyacetic acid (AOAA), and the result was compared with that produced by ... Acetates/therapeutic use , Aminooxyacetic Acid/therapeutic use , Animals , Clonazepam/therapeutic use , Diazepam/therapeutic ... Aminooxyacetic Acid / Isoniazid / Animals Language: English Year: 1989 Type: Article ...
Global "Aminooxyacetic Acid(AOA) Market 2020-2025" Research Report categorizes the global Aminooxyacetic Acid(AOA) market by ... Global Aminooxyacetic Acid(AOA) Market Huge Growth Opportunity between 2020-2025 LP INFORMATION recently released a research ... report on the Aminooxyacetic Acid(AOA) market analysis, which studies the Aminooxyacetic Acid(AOA)s industry coverage, current ... Global "Acid Violet 43 Market 2020-2025" Research Report categorizes the global Acid Violet 43 market by key players, product ...
... aminooxyacetic acid (AOAC), α-cyano-4-hydroxycinnamic acid (4-HOCA), theonyl-trifluoroacetone (TTFA), and carbonyl cyanide m- ... AOAC, aminooxyacetic acid; AT, α-tocopherol; CCCP, carbonyl cyanide m-chlorophenylhydrazone; DAG, diacylglycerol; DCF-DA, 5-( ... Bicinchoninic acid (BCA) kit was obtained from Pierce. Enhanced chemiluminescence (ECL) and PKC activity kits were purchased ... Kadri-Hassani N, Leger CL, Descomps B: The fatty acid bimodal action on superoxide production by human adherent monocytes under ...
In tissue homogenates, the non-specific KAT inhibitor aminooxyacetic acid (AOAA; 1 mM) reduced KYNA production from L-KYN and D ... Addition of DAAO inhibitors (benzoic acid, kojic acid or 3-methylpyrazole-5-carboxylic acid; 5 µM each) attenuated KYNA ... Addition of DAAO inhibitors (benzoic acid, kojic acid or 3-methylpyrazole-5-carboxylic acid; 5 µM each) attenuated KYNA ... In tissue homogenates, the non-specific KAT inhibitor aminooxyacetic acid (AOAA; 1 mM) reduced KYNA production from L-KYN and D ...
Aminooxyacetic acid (C13408). 3-Mercaptopropionic acid (M5801). γ-Acetylenic GABA (A230). GABA (A2129). │ │---------------→. │ ... Aminooxyacetic acid (C13408). 3-Mercaptopropionic acid (M5801). γ-Vinyl GABA (V8261). GABAculine (A3539). ... Aminooxyacetic acid (C13408). α-Ketoglutarate (m) (K1750). │ │---------------→. ↓. Dicarboxylate carrier. Malate (02300). ... Another problem with amino-oxyacetic acid is that it potently inhibits both glutamate decarboxylase and GABA-transaminase (see ...
... aminooxyacetic acid (AOAC), α-cyano-4-hydroxycinnamic acid (4-HOCA), theonyl-trifluoroacetone (TTFA), and carbonyl cyanide m- ... AOAC, aminooxyacetic acid; AT, α-tocopherol; CCCP, carbonyl cyanide m-chlorophenylhydrazone; DAG, diacylglycerol; DCF-DA, 5-( ... Bicinchoninic acid (BCA) kit was obtained from Pierce. Enhanced chemiluminescence (ECL) and PKC activity kits were purchased ... Kadri-Hassani N, Leger CL, Descomps B: The fatty acid bimodal action on superoxide production by human adherent monocytes under ...
... were performed in the presence and absence of aminooxyacetic acid. As shown in Table 3, aminooxyacetic acid was able to ... aminooxyacetic acid. MTT. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. MSeCys. Se-methyl-l-selenocysteine. H2 ... At this concentration aminooxyacetic acid alone had no effect on the cell viability of both cell lines (Fig. 3, A and B). ... Furthermore, 250 μM aminooxyacetic acid, a well known potent inhibitor of PLP-dependent β-lyases, was shown to reduce the ...
1-Aminocyclopropane-1-carboxylic acid. AOA. Aminooxyacetic acid. ARF. Adventitious root formation ... De Klerk GJ, Ter Brugge J, Marinova S (1997) Effectiveness of indoleacetic acid, indolebutyric acid and naphthaleneacetic acid ... acetic acid and indole-3-butyric acid on internal levels of the respective auxins and their conjugation with aspartic acid ... Cuttings with indolbutyric acid in five media. Ciênc Rural 29:207-211. doi: 10.1590/S0103-84781999000200004 Google Scholar ...
Inhibitors: aminooxyacetic acid and vigabatrin. Vigabatrin used to treat epilepsy 27 Which GABA receptors are IONOTROPIC? ...
It has been clearly demonstrated that dormancy is induced by abscisic acid (ABA) during seed development on the mother plant. ... It has been clearly demonstrated that dormancy is induced by abscisic acid (ABA) during seed development on the mother plant. ... amino-oxyacetic acid), ACO activity (CoCl2; α-AIB: α-aminoisobutyric acid), or ethylene action (2,5 NBD: 2,5-norbornadiene; STS ... ABA, abscisic acid; ABI3, ABA insensitive3; ABI5, ABA insensitive5; ACC, 1-aminocyclopropane 1-carboxylic acid; ACO, ACC ...
at 19-21 days of age, mutants have prolonged periods of great rigor or stiffness; therapy with aminooxyacetic acid is helpful ...
Aminoethoxyvinylglycine (AVG), Aminooxyacetic acid (AOA), and silver salts are ethylene inhibitors. Inhibiting ethylene ... Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme ... SAM is then converted to 1-aminocyclopropane-1-carboxylic acid (ACC) by the enzyme ACC synthase (ACS). The activity of ACS ... Smoke contains ethylene, and once this was realized the smoke was replaced with ethephon or naphthalene acetic acid, which ...
Aminooxyacetic Acid (administration & dosage, pharmacology) *Animals. *Anoxia (complications) *Hydrogen Sulfide (administration ...
aminooxyacetic acid. HPLC. high performance liquid chromatography. FAB-MS. fast atom bombardment-mass spectrometry. FMO. flavin ...
Aminooxyacetic Acid 6. NG-Nitroarginine Methyl Ester (L-NAME) 7. Thioredoxins 8. Oxygen ...
Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated ... gamma-Aminobutyric acid, or γ-aminobutyric acid /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, or GABA /ˈɡæbə/, is the chief inhibitory ... Although in chemical terms, GABA is an amino acid (as it has both a primary amine and a carboxylic acid functional group), it ... By convention the term "amino acid", when used without a qualifier, refers specifically to an alpha amino acid. GABA is not an ...
The binding of 2-aminooxyacetic acid.AOA, a mimic of β-alanine, is a known inhibitor of aminotransferases (72) and also ... a number of β-amino acids and α-amino acids were tested (Table 1). The results show that VpAT acts exclusively on β-amino acids ... The simplest β-amino acid, β-alanine, occurs in carnosine, coenzyme A, and pantothenic acid. Other β-amino acids are present in ... and 2-aminooxyacetic acid (AOA) were purchased from Sigma-Aldrich. (S)-β-Phenylalanine and (R)-β-phenylalanine were purchased ...
Aminoethoxyvinylglycine (AVG), Aminooxyacetic acid (AOA), and silver salts are ethylene inhibitors.[44][45] Inhibiting ethylene ... Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol). *Unsorted benzodiazepine site positive ... Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme ... Ethylene appears to have been discovered by Johann Joachim Becher, who obtained it by heating ethanol with sulfuric acid;[48] ...
  • Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. (wikipedia.org)
  • aminooxyacetic acid (AOAA), and the result was compared with that produced by the two drugs independently. (bvsalud.org)
  • During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased. (bvsalud.org)
  • At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. (wikipedia.org)
  • Aminooxyacetic acid is a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes. (wikipedia.org)
  • Aminooxyacetic acid was previously used in a clinical trial to reduce symptoms of Huntington's disease by increasing GABA levels in the brain. (wikipedia.org)
  • The protective effect of two benzodiazepine compounds , diazepam and clonazepam was tested against isoniazid (INH)- induced convulsions in rats pretreated with the gamma-amino- butyric acid ( GABA ) transaminase inhibitor viz. (bvsalud.org)
  • Another problem with amino-oxyacetic acid is that it potently inhibits both glutamate decarboxylase and GABA-transaminase (see Table below). (sigmaaldrich.com)
  • It appears that glutamate formed from glutamine may be metabolized in the tricarboxylic acid (TCA) cycle prior to its conversion to GABA, which may allow new alternative regulatory mechanisms. (sigmaaldrich.com)
  • However, in the case of the carbonyl-trapping agent aminooxyacetic acid its Ki value for inhibition of GABA-transaminase is 10-fold lower than that for glutamate decarboxylase. (sigmaaldrich.com)
  • Gamma-aminobutyric acid (GABA) regulation of anion flux through ALMT proteins requires a specific amino acid motif in ALMTs that shares similarity with a GABA binding site in mammalian GABA A receptors. (plantcell.org)
  • It acts by inhibiting reuptake at the gamma-aminobutyric acid (GABA) transporter (GAT-1). (springer.com)
  • Glutamic acid decarboxylase 65, 67, and GABA-transaminase mRNA expression and total enzyme activity in the goldfish (Carassius auratus) brain. (nih.gov)
  • There were region-specific changes of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD), with increased GAD-67-immunopositive interneurons in the stratum oriens of the CA1 region of the hippocampus, accompanied by nonsignificant reduction of GAD-67 synapses in the CA3 region. (jneurosci.org)
  • γ-aminobutyric acid (GABA) is intimately involved in basal ganglia function. (scirp.org)
  • Our previous study using a unilaterally lesioned rat model of PD indicated that elevating GABA levels by GABA transaminase inhibitor, aminooxyacetic acid significantly attenuated L-DOPA-induced ERK phosphorylation in the striatum and substantia nigra (SN). (scirp.org)
  • Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian brain (Roberts et al. (psychiatrictimes.com)
  • Gamma-aminobutyric acid is synthesized by decarboxylation of glutamate by cytosolic glutamic acid decarboxylase (GAD) and is metabolized by the mitochondrial enzyme GABA-transaminase (GABA-T) to succinic semialdehyde, which in turn can enter the Krebs cycle to ultimately regenerate glutamate. (psychiatrictimes.com)
  • GAT-1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft. (thefullwiki.org)
  • The invention concerns a method for treating depression or senile dementia using a compound which acts selectively as an agonist of gamma aminobutyric acid (GABA) at GABA autoreceptors with the proviso that the compound is not fengabine and progabide. (justia.com)
  • Among these acute effects are a marked change in the release, synthesis and level of gamma aminobutyric acid (GABA) in the brain. (justia.com)
  • GABA (Gamma-AminoButyric Acid) is an inhibitory neurotransmitter that has a calming and relaxing effect in the brain. (drjockers.com)
  • Our gut microbiome plays an important role with GABA production and helps to convert glutamine and glutamic acid into GABA. (drjockers.com)
  • GABA is synthesized from the amino acid glutamate with the enzyme glutamate decarboxylase (GAD) and pyridoxal phosphate (which is the activated form of vitamin B6) as the key cofactor. (drjockers.com)
  • Various nonproteinogenic β-amino acids occur naturally as free metabolites and as components of biosynthetic products ( 1 ). (asm.org)
  • Other β-amino acids are present in bioactive peptides, such as the protease inhibitor bestatin, which contains a (2 S ,3 R )-3-amino-2-hydroxy-4-phenylbutanoyl group, and microcystin, a cyclic nonribosomal peptide that acts as a phosphatase inhibitor and contains both an aliphatic and an aromatic β-amino acid moiety ( 2 - 4 ). (asm.org)
  • Other β-amino acids occur as building blocks in β-lactam antibiotics ( 4 , 7 ) and in antifungal compounds, such as jasplakinolide ( 8 ). (asm.org)
  • Various amino acids were found to inhibit both brain and liver AspD. (nus.edu.sg)
  • Balcar, V.J., 2002, Molecular pharmacology of the Na + -dependent transport of acidic amino acids in the mammalian central nervous system. (springer.com)
  • This was done using only natural amino acids, thereby allowing for both synthetic and recombinant production. (diva-portal.org)
  • An easy fluorimetric assay for measuring D-amino acid oxidase (DAAO) activity by using one of the D-amino acids - D-kynurenine (D-KYN) - as a substrate was applied to assess DAAO activity in the cerebrum, cerebellum, and brainstem of Sprague-Dawley (SD) male rats. (go.jp)
  • Some cancers are attracted to glutamine, one of the 20 common amino acids that code for a genetic sequence or code. (wikibooks.org)
  • In fact, glutamine plays an important role in up-taking essential amino acids and activating TOR kinase, which is a specific enzyme that is necessary for balancing protein synthesis and degradation. (wikibooks.org)
  • Typically these compounds are in the form of nucleotides and essential amino acids. (wikibooks.org)
  • Glutamic acid becomes the primary donor of nitrogen for synthesizing nonessential amino acids. (wikibooks.org)
  • Transaminases are specific enzyme that aid in transferring the amino group of glutamic acid to α-ketoacids which are used to create nonessential amino acids. (wikibooks.org)
  • Through the study of yeast, it was concluded that there needs to be a sufficient level of amino acids for TORC1 to be properly activated. (wikibooks.org)
  • Studies of cell lines of mTORC1 showed that cells depended not only on the presence of essential amino acids but also glutamine at the same time. (wikibooks.org)
  • From studying how glutamine is taken up through an importer called SLC1A5 showed that glutamine was exported using SLC7A5 which exchanges glutamine for uptake of essential amino acids. (wikibooks.org)
  • Additionally, glutamine serves as an important nitrogen donor for assembly of amino acids, nucleotides and nicotinamide. (biomedcentral.com)
  • In protein science , an Imino Acid (Secondary Amino Acid) is a molecule, related to amino acids (differing in the bonding to the nitrogen), that contains both an imino (>C=NH) and a carboxyl (-C(=O)-OH) functional group, which occurs as either an acyclic acid or a cyclic imino acid . (wellnessadvocate.com)
  • quinolinic acid (QUIN)] and neuroprotective [kynurenic acid (KYNA)] KP metabolites. (pnas.org)
  • Because of this, cancer cells can then secrete extra glycolytic metabolites in the from of lactic acid. (wikibooks.org)
  • In addition, the histopathological result was consistent with that of the serum metabolomic analysis, and the changes in serum metabolites in each sausage diet group and the NDMA group were consistently associated with disorders of lipids, amino acid, and energy metabolism. (foodandnutritionresearch.net)
  • The mitochondrial tricarboxylic acid cycle (TCA cycle) provides additional metabolites that funnel into lipid, amino acid and nucleotide synthesis. (biomedcentral.com)
  • Bis(Boc-aminooxy)acetic acid employed as a protecting reagent and intermediate pharmaceuticals and chemical research. (fishersci.dk)
  • In this study, experiments were conducted both in vitro (using cell cultures) and in vivo (using mice) to test the effect of a chemical compound called " (aminooxy)acetic acid " (AOA). (medicalnewstoday.com)
  • The phytotoxicity of acifluorfen and oxyfluorfen [2-chloro-l-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene] to spinach is counteracted by appropriate treatments with (aminooxy)acetic acid, L-2-(aminooxy)-3-phenylpropionic acid, or silver nitrate and by heat shock. (elsevier.com)
  • Under certain conditions soybean injury is ameliorated by combining (aminooxy)acetic acid with acifluorfen and silver nitrate with oxyfluorfen. (elsevier.com)
  • Complete submergence of rice plants under water for 10 days in presence of an ethylene-biosynthetic inhibitor, aminooxy acetic acid (AOA), resulted in appreciable lowering of lodging during post-submergence period when compared with plants submerged without AOA. (bdsbmb.org)
  • Aminooxy acetic acid (AOA) - chilling-chlorophyll-ethylene- gibberellic acid (GA) - germination-lodging - submergence. (bdsbmb.org)
  • A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. (drugbank.ca)
  • The level of GAD67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels. (nih.gov)
  • Effects of increased gamma-aminobutyric acid levels on GAD67 protein and mRNA levels in rat cerebral cortex. (nih.gov)
  • Choi, S. and Silverman, R.B., 2002, Inactivation and inhibition of gamma-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues. (springer.com)
  • The Emerging Role of GABAergic Mechanisms in Mood Disorders by Po W. Wang, M.D., and Terence A. Ketter, M.D. Gamma-aminobutyric acid is a major inhibitory neurotransmitter widely distributed in the mammalian central nervous system. (psychiatrictimes.com)
  • Gamma-aminobutyric acid binds to neuronal and glial recognition sites. (psychiatrictimes.com)
  • The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain. (thefullwiki.org)
  • Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition. (thefullwiki.org)
  • 1998). "Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex. (thefullwiki.org)
  • Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation. (thefullwiki.org)
  • Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes. (thefullwiki.org)
  • The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV. (thefullwiki.org)
  • Also, the inhibition of aspartate aminotransferase by aminooxyacetic acid has clinical implications for the treatment of breast cancer, since a decrease in glycolysis disrupts breast adenocarcinoma cells more than normal cells. (wikipedia.org)
  • Moreover, selective inhibition of aspartate aminotransferase with aminooxyacetic acid ameliorated experimental autoimmune encephalomyelitis in a therapeutic mouse model by reprograming the differentiation of pro-inflammatory T helper 17 cells, that boost the immune system, towards induced anti-inflammatory regulatory T cells. (wikipedia.org)
  • Papapetropoulos A, Zhou J, Hellmich MR, Szabo C. ( 2016 ) Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach. (utmb.edu)
  • It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with. (drugbank.ca)
  • Its pharmacological effect is thought to be mediated through inhibition of the enzyme cyclooxygenase (COX), the enzyme responsible for catalyzes the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway. (drugbank.ca)
  • Aminooxyacetic acid can also inhibit 1-aminocyclopropane-1-carboxylate synthase preventing ethylene synthesis, which can increase the vase life of cut flowers. (wikipedia.org)
  • This compound belongs to the class of organic compounds known as carboxylic acids. (drugbank.ca)
  • ureidooxy carboxylic acids (3) and their derivatives as plant growth regulators and herbicides. (justia.com)
  • In organic chemistry , Acyclic Acids (Ethanoic Acids) , as organic compounds are 2 carbon straight-chain saturated carboxylic acids , that have an open-chain molecular structures as opposed to ring-shaped structures. (wellnessadvocate.com)
  • effects of ethylene inhibitors, silver nitrate (agno3), cobalt chloride (cocl2) and aminooxyacetic acid (aoa), on in vitro shoot induction and rooting of banana (musa acuminata l. (academicjournals.org)
  • Expression of CsHA1 , CsFRO1 , and CsIRT1 is diminished in Fe-deficient roots by treatment with ethylene inhibitors, such as Co (cobalt) or AOA (aminooxyacetic acid). (unl.edu)
  • The addition of specific DAAO inhibitors, such as 3-methylpyrazole-5-carboxylic acid and 4 H -thieno [3, 2-b] pyrrole-5-carboxylic acid (Compound 8), significantly attenuated the fluorescence intensity of KYNA, suggesting that DAAO present in the rat brain homogenates was responsible for the production of KYNA. (go.jp)
  • However relaxation responses were reduced by L-NNA (100 µM) an inhibitor of nitric oxide (NO) synthesis (40-50% reduction), zinc protoprophyrin IX (10 µM) an inhibitor of carbon monoxide (CO) synthesis (20-40% reduction) and also propargylglycine (30 µM) and aminooxyacetic acid (30 µM), inhibitors of hydrogen sulphide (H2S) synthesis (15-20% reduction). (edu.au)
  • The perception of this gaseous two-carbon hormone is achieved by a group of membrane-associated dimeric ethylene receptors that resemble bacterial two-component signaling systems and are composed of hybrid histidine (or aspartic acid) kinases, a histidine-containing phosphor-transfer domain, and response regulators ( 2 ). (mcponline.org)
  • It was found that preliminary treatment before self-pollination of stigmas of petunia self-incompatible line with aminooxyacetic acid (AOA), inhibitor of ACC synthesis, led to stimulation of pollen tubes growth when the latter did not exhibit any hallmarks of PCD. (springer.com)
  • ACC synthesis increases with high levels of auxins, especially indole acetic acid (IAA) and cytokinins. (wikipedia.org)
  • 3 R )-3-[(1 R )-1-( tert -Butyldimethylsilyl)oxy-1-(2-methoxy-4,5-methylenedioxyphenyl)methyl]-2-methylene-4-butanolide, which is a key intermediate for the synthesis of 1,2-oxidized furofuran lignan, was stereoselectively synthesized from L -glutamic acid by applying direct methylenation to butanolide. (go.jp)
  • c) treatment with H2S synthesis inhibitor aminooxyacetic acid (ΑΟΑΑ) or propargylglycine (PAG) and d) H2S donor sodium thiosulfate (STS) or GYY3147. (bvsalud.org)
  • Synergistic anticonvulsant action of diazepam & clonazepam with amino-oxyacetic acid against isoniazid-induced convulsions in rats. (bvsalud.org)
  • 2019 ) Effects of aminooxyacetic acid on hippocampal mitochondria in rats with chronic alcoholism: the analysis of learning and memory-related genes. (academictree.org)
  • Behavioral and pharmacological effects of centrally administered aminooxyacetic acid in rats. (cookleave.info)
  • This is particularly serious for aminooxyacetic acid, which at high concentrations will inhibit all pyridoxal phosphate-dependent enzymes. (sigmaaldrich.com)
  • however, the article published in Anesthesiology, January 1997, clearly showed that aminooxyacetic acid did not inhibit compound A-mediated renal necrosis or glucosuria, a finding suggesting that pathways of metabolism other than that mediated by renal cysteine conjugate [small beta, Greek]-lyase contributed to the nephrotoxicity of compound A. (asahq.org)
  • The protective activity against cisplatin-induced cytotoxicity and ROS generation was blocked by aminooxyacetic acid, a selective inhibitor of pyridoxal 5′-phosphate-dependent cysteine conjugate β-lyases, further supporting the role of β-lyase in the observed chemoprotection. (aspetjournals.org)
  • The invention is also directed to the use of the receptor for diagnostics of Helicobacter pylori, to a method of producing chondroitin oligosaccharides from chondroitin sulphates, and a method for production of amidated glucuronic acid comprising oligosaccharides and monosaccharides from glucuronic acid comprising polysaccharides. (sumobrain.com)
  • Aminooxyacetic acid inhibits aspartate aminotransferase, another PLP-dependent enzyme, which is an essential part of the malate-aspartate shuttle. (wikipedia.org)
  • Some examples of α-ketoacids include pyruvate, oxaloacetate, or gamma-semialdehyde which are also used to synthesize nonessential acids such as alanine, serine or aspartate. (wikibooks.org)
  • It has been clearly demonstrated that dormancy is induced by abscisic acid (ABA) during seed development on the mother plant. (frontiersin.org)
  • Plant senescence is regulated by a coordinated genetic program mediated in part by changes in ethylene, abscisic acid (ABA), and cytokinin content. (plantphysiol.org)
  • Senescence is accompanied by changes in endogenous ethylene, abscisic acid (ABA), and cytokinins, and these changes are believed to mediate signaling events that control the process. (plantphysiol.org)
  • The plant growth regulator abscisic acid (ABA) can cause physiological responses that protect plants against CI or LTI. (core.ac.uk)
  • Kynurenic acid (KYNA), an astrocyte-derived, endogenous antagonist of α7 nicotinic acetylcholine and excitatory amino acid receptors, regulates glutamatergic, GABAergic, cholinergic and dopaminergic neurotransmission in several regions of the rodent brain. (frontiersin.org)
  • In this assay, DAAO produces kynurenic acid (KYNA) from D-KYN, and the fluorescence originating from KYNA can then be used to evaluate DAAO activity. (go.jp)
  • The crystal structure was used to rationalize the stereo- and regioselectivity of V. paradoxus aminotransferase and to define a sequence motif with which new aromatic β-amino acid-converting aminotransferases may be identified. (asm.org)
  • Bixel, M.G., Hutson, S.M. and Hamprecht, B., 1997, Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture. (springer.com)
  • In contrast, an inhibitor of aminotransferase (AT), aminooxyacetic acid, did not decrease KYNA production from D-KYN, meaning that AT could not metabolize D-KYN to KYNA under the present conditions. (go.jp)
  • Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme Met adenosyltransferase. (wikipedia.org)
  • SAM is then converted to 1-aminocyclopropane-1-carboxylic acid (ACC) by the enzyme ACC synthase (ACS). (wikipedia.org)
  • Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. (nih.gov)
  • This invention specifically relates to amino thioxomethyl amino oxyacetic acid derivatives that elevate HDL cholesterol concentration and which may be useful for the treatment of atherosclerotic conditions such as, coronary heart disease. (justia.com)
  • Aminooxyacetic acid has been shown to cause excitotoxic lesions of the striatum, similar to Huntington's disease, potentially due to its impairment of mitochondrial energy metabolism. (wikipedia.org)
  • The medium was evaluated for its ability to support growth of the yeast phase of P. brasiliensis at 37 °C. Cultures were followed for 240 h and growth patterns were determined by measuring optical density, dry weight, nucleic acids and protein. (microbiologyresearch.org)
  • The present study was undertaken to investigate the effect of established anticonvulsants, such as valproic acid, carbamazepine, gabapentin, diazepam, lacosamide and pregabalin against pentylenetetrazole (6 mM) seizures in adult zebrafish. (ijpsonline.com)
  • Kuhse, J., Schmieden, V. & Betz, H. A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit. (nature.com)
  • Schmieden, V., Kuhse, J. & Betz, H. Agonist pharmacology of neonatal and adult glycine receptor α subunits: identification of amino acid residues involved in taurine activation. (nature.com)
  • However, alternative routes, including KYNA formation from D-kynurenine (D-KYN) by D-amino acid oxidase (DAAO) and the direct transformation of kynurenine to KYNA by reactive oxygen species (ROS), have been demonstrated in the rat brain. (frontiersin.org)
  • Also in the nerve terminals, aminooxyacetic acid prevents the mitochondria from utilizing pyruvate generated from glycolysis, thus leading to a bioenergetic state similar to that of hypoglycemia. (wikipedia.org)
  • mTORC1 is typically a major regulator of cell growth and activates protein translation but inhibits the response of macrophages to excess amino acid production. (wikibooks.org)
  • Mice lacking the neuronal NOS (nNOS) isoform have a phenotype that could be explained by decreased availability of glutamate, an amino acid that is also an excitatory neurotransmitter. (sciencemag.org)
  • Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. (drugbank.ca)
  • By grafting the amino acid sequence -GSECG to the C-terminal of our model-protein, a HER2-binding Affibody molecule, we enabled site specific labeling with both trivalent radiometals and with 99m Tc. (diva-portal.org)
  • Glutamate is derived from and can be converted to glutamine, and oxidation of glutamate feeds into the energy-providing TCA (tricarboxylic acid) cycle. (sciencemag.org)
  • These are compounds containing a carboxylic acid group with the formula -C(=O)OH. (drugbank.ca)
  • Among the compounds disclosed is 5-chloro-2-methylphenyl thioureido acetic acid (2). (justia.com)
  • In view of the growing importance of pharmaceutical compounds containing β-amino acid groups, there is demand for new tools for their production in enantiopure form. (asm.org)
  • The objective of this study was to investigate the effects of amino acid compositions and their concentration on the Bt toxin content in Bt cotton to gain a better physiological understanding of the observed phenomenon. (usda.gov)
  • It has been studied by Otto Warburg, a notable German physiologist and Nobel Laureate, that cancer cells seem to uptake more glucose and produce more lactic acid than regular cells or tissues. (wikibooks.org)
  • Also in 1936, Kitagawa and Takani described the preparation of aminooxyacetic acid by the condensation of benzhydroxamic acid and ethyl bromoacetate, followed by hydrolysis by hydrochloric acid. (wikipedia.org)
  • Aminooxyacetic acid also has anticonvulsant properties. (wikipedia.org)