Aminooxyacetic Acid
Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats. (1/114)
cis-3-(9H-Purin-6-ylthio)acrylic acid (PTA) is a structural analog of azathioprine, a prodrug of the antitumor and immunosuppressive drug 6-mercaptopurine (6-MP). In this study, we examined the in vitro and in vivo metabolism of PTA in rats. Two metabolites of PTA, 6-MP and the major metabolite, S-(9H-purin-6-yl)glutathione (PG), were formed in a time- and GSH-dependent manner in vitro. Formation of 6-MP and PG occurred nonenzymatically, but 6-MP formation was enhanced 2- and 7-fold by the addition of liver and kidney homogenates, respectively. Purified rat liver glutathione S-transferases enhanced 6-MP formation from PTA by 1.8-fold, whereas human recombinant alpha, mu, and pi isozymes enhanced 6-MP formation by 1.7-, 1.3-, and 1.3-fold, respectively. In kidney homogenate incubations, PG accumulation was only observed during the first 15 min because of further metabolism by gamma-glutamyltranspeptidase, dipeptidase, and beta-lyase to yield 6-MP, as indicated by the use of the inhibitors acivicin and aminooxyacetic acid. Based on these results and other lines of evidence, two different GSH-dependent pathways are proposed for 6-MP formation: an indirect pathway involving PG formation and further metabolism to 6-MP, and a direct pathway in which PTA acts as a Michael acceptor. HPLC analyses of urine of rats treated i.p. with PTA (100 mg/kg) showed that 6-MP was formed in vivo and excreted in urine without apparent liver or kidney toxicity. Collectively, these studies show that PTA is metabolized to 6-MP both in vitro and in vivo and may therefore be a useful prodrug of 6-MP. (+info)GABA agonists differentially modify blood glucose levels of diabetic rats. (2/114)
This study described the effects of GABA agonists on glucose plasma concentrations of streptozotocin-induced diabetic rats. Low doses of an indirect GABA agonist, AOAA (aminooxyacetic acid); a GABA(A) and a GABA(B) agent, THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridone) and baclofen, respectively; and a benzodiazepine were administered to non-diabetic and to diabetic rats. Plasma glucose concentrations were estimated during fasting and after an oral glucose load. Diazepam (1 mg/kg), baclofen (1 mg/kg) and AOAA (30 mg/kg), significantly decreased glycemia after oral glucose overload of streptozotocin-induced diabetes. None of the GABA-acting agents tested changed fasting or glucose overload glycemia of normal rats. Diazepam was the only drug to increase the fasting blood glucose concentration of diabetic rats. Treatment with AOAA or diazepam was accompanied by increased insulin plasma concentrations in diabetic rats to levels similar to the ones of non-diabetic animals. These results demonstrate that benzodiazepines and other GABA drugs act the endocrine pancreas in vivo, ultimately increasing plasma insulin and decreasing high blood glucose levels of diabetic rats. The acute and prolonged effects of the multitude of drugs acting on the GABA(A)-benzodiazepine-chloride ionophore complex remain to be broadly investigated as a therapeutic tool in diabetes. (+info)Beta-cyanoalanine synthase: purification and characterization. (3/114)
Beta-cyano-L-alanine synthase [L-cysteine hydrogen-sulfide-lyase (adding HCN), EC 4.4.1.9] was purified about 4000-fold from blue lupine seedlings. The enzyme was homoegeneous on gel electrophoresis and free of contamination by other pyridoxal-P-dependent lyases. The enzyme has a molecular weight of 52,000 and contains 1 mole of pyridoxal-P per mole of protein; its isoelectric point is situated at pH 4.7. Its absorption spectrum has two maxima, at 280 and 410 nm. L-Cysteine is the natural primary (amino acid) substrate; beta-chloro- and beta-thiocyano can serve (with considerably lower affinity) instead of cyanide as cosubstrates for cyanoalanine synthase. The synthase is refractory to DL-cycloserine and D-penicillamine, potent inhibitors of many pyridoxal-P-dependent enzymes. Cyanoalanine synthase catalyzes slow isotopic alpha-H exchange in cysteine and in end-product amino acids; the rates of alpha-H exchange in nonreacted (excess) cysteine are markedly increased in the presence of an adequate cosubstrate; no exchange is observed of H atoms in beta-position. (+info)The oscillatory behavior of pancreatic islets from mice with mitochondrial glycerol-3-phosphate dehydrogenase knockout. (4/114)
Glucose stimulation of pancreatic beta cells induces oscillations of the membrane potential, cytosolic Ca(2+) ([Ca(2+)](i)), and insulin secretion. Each of these events depends on glucose metabolism. Both intrinsic oscillations of metabolism and repetitive activation of mitochondrial dehydrogenases by Ca(2+) have been suggested to be decisive for this oscillatory behavior. Among these dehydrogenases, mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), the key enzyme of the glycerol phosphate NADH shuttle, is activated by cytosolic [Ca(2+)](i). In the present study, we compared different types of oscillations in beta cells from wild-type and mGPDH(-/-) mice. In clusters of 5-30 islet cells and in intact islets, 15 mM glucose induced an initial drop of [Ca(2+)](i), followed by an increase in three phases: a marked initial rise, a partial decrease with rapid oscillations and eventually large and slow oscillations. These changes, in particular the frequency of the oscillations and the magnitude of the [Ca(2+)] rise, were similar in wild-type and mGPDH(-/-) mice. Glucose-induced electrical activity (oscillations of the membrane potential with bursts of action potentials) was not altered in mGPDH(-/-) beta cells. In single islets from either type of mouse, insulin secretion strictly followed the changes in [Ca(2+)](i) during imposed oscillations induced by pulses of high K(+) or glucose and during the biphasic elevation induced by sustained stimulation with glucose. An imposed and controlled rise of [Ca(2+)](i) in beta cells similarly increased NAD(P)H fluorescence in control and mGDPH(-/-) islets. Inhibition of the malate-aspartate NADH shuttle with aminooxyacetate only had minor effects in control islets but abolished the electrical, [Ca(2+)](i) and secretory responses in mGPDH(-/-) islets. The results show that the two distinct NADH shuttles play an important but at least partially redundant role in glucose-induced insulin secretion. The oscillatory behavior of beta cells does not depend on the functioning of mGPDH and on metabolic oscillations that would be generated by cyclic activation of this enzyme by Ca(2+). (+info)Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells. (5/114)
Trichloroethylene (Tri) caused modest cytotoxicity in freshly isolated human proximal tubular (hPT) cells, as assessed by significant decreases in lactate dehydrogenase (LDH) activity after 1 h of exposure to 500 microM Tri. Oxidative metabolism of Tri by cytochrome P-450 to form chloral hydrate (CH) was only detectable in kidney microsomes from one patient out of four tested and was not detected in hPT cells. In contrast, GSH conjugation of Tri was detected in cells from every patient tested. The kinetics of Tri metabolism to its GSH conjugate S-(1,2-dichlorovinyl)glutathione (DCVG) followed biphasic kinetics, with apparent Km and Vmax values of 0.51 and 24.9 mM and 0.10 and 1.0 nmol/min per mg protein, respectively. S-(1,2-dichlorovinyl)-L-cysteine (DCVC), the cysteine conjugate metabolite of Tri that is considered the penultimate nephrotoxic species, caused both time- and concentration-dependent increases in LDH release in freshly isolated hPT cells. Preincubation of hPT cells with 0.1 mM aminooxyacetic acid did not protect hPT cells from DCVC-induced cellular injury, suggesting that another enzyme besides the cysteine conjugate beta-lyase may be important in DCVC bioactivation. This study is the first to measure the cytotoxicity and metabolism of Tri and DCVC in freshly isolated cells from the human kidney. These data indicate that the pathway involved in the cytotoxicity and metabolism of Tri in hPT cells is the GSH conjugation pathway and that the cytochrome P-450-dependent pathway has little direct role in renal Tri metabolism in humans. (+info)The effect of culture age, chloramphenicol and B6 inhibitors on intra- and extracellular keto and amino acids of Escherichia coli B. (6/114)
Keto acids and free amino acids were assayed in the cells and the medium of Escherichia coli B growing in the presence of chloramphenicol, cycloserines, aminooxyacetate, and limiting nitrogen source. Under these growth-limiting conditions the cells accumulated ketoglutarate and 'ketovaline' but no other keto acids. In all experiments only ketoglutarate, pyruvate, and 'ketovaline' were found in the medium. Amino acids are released into the medium in the early phases of growth and the composition of the extracellular amino acids is similar to that of the amino acid pool. The concentrations of free amino acids were 10-3-10-4 times higher in the cell than in the medium. The internal pool composition is fixed under all growth-limiting conditions. In the presence of the drugs the cells release amino acids into the medium. (+info)Use of sulfhydryl reagents to investigate branched chain alpha-keto acid transport in mitochondria. (7/114)
The goal of this paper was to determine the contribution of the mitochondrial branched chain aminotransferase (BCATm) to branched chain alpha-keto acid transport within rat heart mitochondria. Isolated heart mitochondria were treated with sulfhydryl reagents of varying permeability, and the data suggest that essential cysteine residues in BCATm are accessible from the cytosolic face of the inner membrane. Treatment with 15 nmol/mg N-ethylmaleimide (NEM) inhibited initial rates of alpha-ketoisocaproate (KIC) uptake in reconstituted mitochondrial detergent extracts by 70% and in the intact organelle by 50%. KIC protected against inhibition suggesting that NEM labeled a cysteine residue that is inaccessible when substrate is bound to the enzyme. Additionally, the apparent mitochondrial equilibrium KIC concentration was decreased 50-60% after NEM labeling, and this difference could not be attributed to effects of NEM on matrix pH or KIC oxidation. In fact, NEM was a better inhibitor of KIC oxidation than rotenone. Measuring matrix aspartate and glutamate levels revealed that the effects of NEM on the steady-state KIC concentration resulted from inhibition of BCATm catalyzed transamination of KIC with matrix glutamate to form leucine. Furthermore, circular dichroism spectra of recombinant human BCATm with liposomes showed that the commercial lipids used in the reconstituted transport assay contain BCAT amino acid substrates. Thus BCATm is distinct from the branched chain alpha-keto acid carrier but may interact with the inner mitochondrial membrane, and it is necessary to inhibit or remove transaminase activity in both intact and reconstituted systems prior to quantifying transport of alpha-keto acids which are transaminase substrates. (+info)Contribution of glutamate dehydrogenase to mitochondrial glutamate metabolism studied by (13)C and (31)P nuclear magnetic resonance. (8/114)
The relative contribution of glutamate dehydrogenase (GDH) and the aminotransferase activity to mitochondrial glutamate metabolism was investigated in dilute suspensions of purified mitochondria from potato (Solanum tuberosum) tubers. Measurements of glutamate-dependent oxygen consumption by mitochondria in different metabolic states were complemented by novel in situ NMR assays of specific enzymes that metabolize glutamate. First, a new assay for aminotransferase activity, based on the exchange of deuterium between deuterated water and glutamate, provided a method for establishing the effectiveness of the aminotransferase inhibitor amino-oxyacetate in situ, and thus allowed the contribution of the aminotransferase activity to glutamate oxidation to be assessed unambiguously. Secondly, the activity of GDH in the mitochondria was monitored in a coupled assay in which glutamine synthetase was used to trap the ammonium released by the oxidative deamination of glutamate. Thirdly, the reversibility of the GDH reaction was investigated by monitoring the isotopic exchange between glutamate and [(15)N]ammonium. These novel approaches show that the oxidative deamination of glutamate can make a significant contribution to mitochondrial glutamate metabolism and that GDH can support the aminotransferases in funneling carbon from glutamate into the TCA cycle. (+info)
Aminooxyacetic acid - Wikipedia
Aminooxyacetic acid hemichloride
TLR2 and TLR4 interact wi… - University of Gothenburg, Sweden
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lecture14 10 21 08 - Lecture 14 Overview-glycolysis regulation-glucose synthesis-gluconeogenesis regulation Control of the...
Aminooxyacetic acid
... aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. Aminooxyacetic acid is a general ... I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino- ... Also in 1936, Kitagawa and Takani described the preparation of aminooxyacetic acid by the condensation of benzhydroxamic acid ... and was prepared by the hydrolysis of ethylbenzhydroximinoacetic acid. In 1936, Anchel and Shoenheimer used aminooxyacetic acid ...
Ethylene as a plant hormone
Aminoethoxyvinylglycine (AVG), Aminooxyacetic acid (AOA), and silver salts are ethylene inhibitors. Inhibiting ethylene ... Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme ... SAM is then converted to 1-aminocyclopropane-1-carboxylic acid (ACC) by the enzyme ACC synthase (ACS). The activity of ACS ... Smoke contains ethylene, and once this was realized the smoke was replaced with ethephon or naphthalene acetic acid, which ...
GABA tea
"Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals". Neuropharmacology. 10 (1): ... Sheng-Dun Lin, et al., Bioactive components and antioxidant properties of g-aminobutyric acid (GABA) tea leaves. LWT - Food ... began developing GABA-rich tea in 1984 and successfully produced a new type tea in which almost all glutamic acid has been ... Effect of green tea rich in gamma-aminobutyric acid on blood pressure of Dahl saltsensitive rats. Am J Hypertens. 1995, 8: 74- ...
Gamma-Hydroxybutyric acid
Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-gamma-aminobutyric acid in normal and amino oxyacetic acid- ... gamma-Hydroxybutyric acid (or γ-hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid) is a naturally occurring ... Beta-Hydroxybutyric acid γ-Hydroxyvaleric acid (GHV) γ-Valerolactone (GVL) β-Hydroxy β-methylbutyric acid (HMB) "Pingers, ... May 2003). "A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand". ...
Γ-Aminobutyric acid
Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated ... Although in chemical terms, GABA is an amino acid (as it has both a primary amine and a carboxylic acid functional group), it ... By convention the term "amino acid", when used without a qualifier, refers specifically to an alpha amino acid. GABA is not an ... γ-Aminobutyric acid (gamma-aminobutyric acid) /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, or GABA /ˈɡæbə/, is the chief inhibitory ...
4-aminobutyrate transaminase
Aminooxyacetic acid Gabaculine Phenelzine Phenylethylidenehydrazine (PEH) Rosmarinic acid Valproic acid Vigabatrin "4- ... As a transaminase, GABA-T's role is to move functional groups from an amino acid and a α-keto acid, and vice versa. In the case ... This succinate will then enter mitochondrion and become part of the citric acid cycle. The critic acid cycle can then produce 2 ... Amino acid residues found in the active site of 4-aminobutyrate transaminase include Lys-329, which are found on each of the ...
1-Aminocyclopropane-1-carboxylate synthase
ACC Synthase is also competitively inhibited by aminoethoxyvinylglycine (AVG) and aminooxyacetic acid (AOA), inhibitors to many ... α-keto-γ-methylthiobutyric acid, and S-adenosylhomocysteine. ACC Synthase is 450-516 amino acid long sequence depending on the ... 1-aminocyclopropane-1-carboxylic acid synthase, 1-aminocyclopropane-1-carboxylate synthetase, aminocyclopropanecarboxylic acid ... The reaction catalyzed by 1-aminocyclopropane-1-carboxylic acid synthase (ACS) is the committed and rate-limiting step in the ...
C2H5NO3
The molecular formula C2H5NO3 (molar mass: 91.07 g/mol, exact mass: 91.0269 u) may refer to: Aminooxyacetic acid (AOA or AOAA) ...
List of MeSH codes (D02)
... aminooxyacetic acid MeSH D02.241.081.038.440 - edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... aminooxyacetic acid MeSH D02.092.570.394 - hydroxamic acids MeSH D02.092.570.394.150 - bufexamac MeSH D02.092.570.394.265 - ... hexuronic acids MeSH D02.241.081.844.915.400.500 - iduronic acid MeSH D02.241.081.901.177 - aconitic acid MeSH D02.241.081.901. ...
Fmoc-2-(aminooxy)acetic acid | Amino Acids | Proteomics | Products | MoBiTec Molecular Biotechnology
Boc-Gly-OH Novabiochem 4530-20-5
Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic...
FX11, oligomycin, aminooxyacetic acid (AOA) and phenformin plates were read 4 d later on the IncuCyte S3 using phase object ... and IC50 values for aminooxyacetic acid (AOA) (d), oligomycin (e) and phenformin (f); n = 3 biological replicates per cell line ... phenformin and aminooxyacetic acid were obtained from Sigma, trans-ISRIB was obtained from Cayman Chemical and GCN2iB was ... formic acid in water and mobile phase B consisting of 0.1% formic acid in acetonitrile. The following gradient was used: mobile ...
三共研究所年報 - Webcat Plus
Agrochemicals Effects of Aminooxyacetic Acid and its Derivatives on Flowering in Pharbitis nil / Tadashi AMAGASA ... Microbiology & Fermentation Isolation of 2-Acetylamino-3-hydroxy-4-methyloct-6-enolic Acid, a Der-ivative of the C9-Amino Acid ... Note Synthesis and Diuretic Activity of 4-Oxo-1H-cyclopent[de]indolo[3,2,1-ij]quinoline-11-carboxylic Acids / Yasuo SHIMOJI ... Agrochemicals Quantitative Evaluation of the Weak Acid Hypothesis as the Mechanism for 2,4-D Absorption by Corn Root ...
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.241.81.114.968.249 Aminolevulinic Acid D2.241.607.547.276 D2.241.755.547.276 Aminooxyacetic Acid D2.241.81.38.350 D2.241. ... D10.251.400.143 Butyric Acid D2.241.81.160.140 D2.241.81.114.750 D10.251.400.241.140 D10.251.400.143.500 Caffeic Acids D2.241. ... B5.80.750.450 Keto Acids D2.241.607 D2.241.755 Ketoglutaric Acids D2.241.607.465 D2.241.755.465 L-Selectin D23.50.301.264. ... D2.705.675 Phosphoric Acid Esters D2.705.673 D2.705.400 (Replaced for 2012 by Organophosphates) Phosphorous Acids D2.705.676 ...
DeCS
Aminooxyacetic Acid - Preferred Concept UI. M0000955. Scope note. A compound that inhibits aminobutyrate aminotransferase ... A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid ... activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. ...
Pharmacological Actions of Hydrogen Sulfide Donors on Sympathetic Neurotransmission in the Bovine Anterior Uvea, In Vitro -...
104091-08-9 | Fmoc-D-Glu(OtBu)-OH | Next Peptide
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Ácido gama-aminobutírico - Wikipédia, a enciclopédia livre
Kuriyama K, Sze PY (janeiro de 1971). «Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated ... Kuriyama K, Sze PY (janeiro de 1971). «Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated ... Sapse AM (2000). Molecular Orbital Calculations for Amino Acids and Peptides. [S.l.]: Birkhäuser. ISBN 978-0-8176-3893-1. [ ... Bown AW, Shelp BJ (setembro de 1997). «The Metabolism and Functions of γ-Aminobutyric Acid». Plant Physiol. 115 (1): 1-5. PMC ...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
... aminooxyacetic acid (AOAA, inhibitor of CBS), and L-aspartic acid (L-Asp, inhibitor of 3-MPST) were used to determine the role ... In this study, aminooxyacetic acid (AOAA, an inhibitor of cystathionine-ß-synthase), dl-propargylglycine (PAG, an inhibitor of ... Furthermore, aminooxyacetic acid (an inhibitor of CBS) dose-dependently inhibited thyroid carcinoma cell growth. CBS can ... Hyaluronic acid (HA) is widely adopted in tissue engineering and drug delivery. 5-(4-Hydroxyphenyl)-3H-1, 2-dithiol-3-thione ( ...
ADC Linker | ADCs| CSNpharm
t-Boc-aminooxyacetic acid N-hydroxysuccinimide ester is a heterobifunctional linker.. CSN26860. Sulfo-SMCC sodium 92921-24-9. ... Bis-(PEG6-acid)-SS 2055014-97-4. Bis-(PEG6-acid)-SS is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug ... BCN-PEG4-acid 1881221-47-1. BCN-PEG4-acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug ... Acid-propionylamino-Val-Cit-OH 2098907-84-5. Acid-propionylamino-Val-Cit-OH is a cleavable ADC linker used in the synthesis of ...
Hydroxylamines | Harvard Catalyst Profiles | Harvard Catalyst
Review on postharvest quality and handling of apple
Aminooxyacetic acid (AOA) acid and Naphthaleneacetic are used to control ethylene through inhibition of ethylene biosynthesis. ... During fruit ripening and storage, titratable acid content of the fruit declines gradually leading to reduced fruit flavor [11 ... Soluble solid includes organic acids inorganic salts and sugars. Starch degradation as maturity progresses increases the ...
Dissertation sur la Science - Page 4 of 7 - bibliothequer
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.241.81.114.968.249 Aminolevulinic Acid D2.241.607.547.276 D2.241.755.547.276 Aminooxyacetic Acid D2.241.81.38.350 D2.241. ... D10.251.400.143 Butyric Acid D2.241.81.160.140 D2.241.81.114.750 D10.251.400.241.140 D10.251.400.143.500 Caffeic Acids D2.241. ... B5.80.750.450 Keto Acids D2.241.607 D2.241.755 Ketoglutaric Acids D2.241.607.465 D2.241.755.465 L-Selectin D23.50.301.264. ... D2.705.675 Phosphoric Acid Esters D2.705.673 D2.705.400 (Replaced for 2012 by Organophosphates) Phosphorous Acids D2.705.676 ...
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.241.81.114.968.249 Aminolevulinic Acid D2.241.607.547.276 D2.241.755.547.276 Aminooxyacetic Acid D2.241.81.38.350 D2.241. ... D10.251.400.143 Butyric Acid D2.241.81.160.140 D2.241.81.114.750 D10.251.400.241.140 D10.251.400.143.500 Caffeic Acids D2.241. ... B5.80.750.450 Keto Acids D2.241.607 D2.241.755 Ketoglutaric Acids D2.241.607.465 D2.241.755.465 L-Selectin D23.50.301.264. ... D2.705.675 Phosphoric Acid Esters D2.705.673 D2.705.400 (Replaced for 2012 by Organophosphates) Phosphorous Acids D2.705.676 ...
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.241.81.114.968.249 Aminolevulinic Acid D2.241.607.547.276 D2.241.755.547.276 Aminooxyacetic Acid D2.241.81.38.350 D2.241. ... D10.251.400.143 Butyric Acid D2.241.81.160.140 D2.241.81.114.750 D10.251.400.241.140 D10.251.400.143.500 Caffeic Acids D2.241. ... B5.80.750.450 Keto Acids D2.241.607 D2.241.755 Ketoglutaric Acids D2.241.607.465 D2.241.755.465 L-Selectin D23.50.301.264. ... D2.705.675 Phosphoric Acid Esters D2.705.673 D2.705.400 (Replaced for 2012 by Organophosphates) Phosphorous Acids D2.705.676 ...
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.241.81.114.968.249 Aminolevulinic Acid D2.241.607.547.276 D2.241.755.547.276 Aminooxyacetic Acid D2.241.81.38.350 D2.241. ... D10.251.400.143 Butyric Acid D2.241.81.160.140 D2.241.81.114.750 D10.251.400.241.140 D10.251.400.143.500 Caffeic Acids D2.241. ... B5.80.750.450 Keto Acids D2.241.607 D2.241.755 Ketoglutaric Acids D2.241.607.465 D2.241.755.465 L-Selectin D23.50.301.264. ... D2.705.675 Phosphoric Acid Esters D2.705.673 D2.705.400 (Replaced for 2012 by Organophosphates) Phosphorous Acids D2.705.676 ...
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.241.81.114.968.249 Aminolevulinic Acid D2.241.607.547.276 D2.241.755.547.276 Aminooxyacetic Acid D2.241.81.38.350 D2.241. ... D10.251.400.143 Butyric Acid D2.241.81.160.140 D2.241.81.114.750 D10.251.400.241.140 D10.251.400.143.500 Caffeic Acids D2.241. ... B5.80.750.450 Keto Acids D2.241.607 D2.241.755 Ketoglutaric Acids D2.241.607.465 D2.241.755.465 L-Selectin D23.50.301.264. ... D2.705.675 Phosphoric Acid Esters D2.705.673 D2.705.400 (Replaced for 2012 by Organophosphates) Phosphorous Acids D2.705.676 ...
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.241.81.114.968.249 Aminolevulinic Acid D2.241.607.547.276 D2.241.755.547.276 Aminooxyacetic Acid D2.241.81.38.350 D2.241. ... D10.251.400.143 Butyric Acid D2.241.81.160.140 D2.241.81.114.750 D10.251.400.241.140 D10.251.400.143.500 Caffeic Acids D2.241. ... B5.80.750.450 Keto Acids D2.241.607 D2.241.755 Ketoglutaric Acids D2.241.607.465 D2.241.755.465 L-Selectin D23.50.301.264. ... D2.705.675 Phosphoric Acid Esters D2.705.673 D2.705.400 (Replaced for 2012 by Organophosphates) Phosphorous Acids D2.705.676 ...
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.241.81.114.968.249 Aminolevulinic Acid D2.241.607.547.276 D2.241.755.547.276 Aminooxyacetic Acid D2.241.81.38.350 D2.241. ... D10.251.400.143 Butyric Acid D2.241.81.160.140 D2.241.81.114.750 D10.251.400.241.140 D10.251.400.143.500 Caffeic Acids D2.241. ... B5.80.750.450 Keto Acids D2.241.607 D2.241.755 Ketoglutaric Acids D2.241.607.465 D2.241.755.465 L-Selectin D23.50.301.264. ... D2.705.675 Phosphoric Acid Esters D2.705.673 D2.705.400 (Replaced for 2012 by Organophosphates) Phosphorous Acids D2.705.676 ...
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.241.81.114.968.249 Aminolevulinic Acid D2.241.607.547.276 D2.241.755.547.276 Aminooxyacetic Acid D2.241.81.38.350 D2.241. ... D10.251.400.143 Butyric Acid D2.241.81.160.140 D2.241.81.114.750 D10.251.400.241.140 D10.251.400.143.500 Caffeic Acids D2.241. ... B5.80.750.450 Keto Acids D2.241.607 D2.241.755 Ketoglutaric Acids D2.241.607.465 D2.241.755.465 L-Selectin D23.50.301.264. ... D2.705.675 Phosphoric Acid Esters D2.705.673 D2.705.400 (Replaced for 2012 by Organophosphates) Phosphorous Acids D2.705.676 ...
MeSH Browser
Acetic Acid [D02.241.081.018.165] * Acetic Anhydrides [D02.241.081.018.193] * Aminooxyacetic Acid [D02.241.081.018.207] ... Carboxylic Acids [D02.241] * Hydroxy Acids [D02.241.511] * Benzilates [D02.241.511.085] * Glycolates [D02.241.511.316] * ... Hydroxyacetic Acids Related Concept UI. M0569917. Registry Number. 0. Terms. Hydroxyacetic Acids Preferred Term Term UI T815973 ... Carboxylic Acids [D02.241] * Acids, Acyclic [D02.241.081] * Acetates [D02.241.081.018] * Acetamides [D02.241.081.018.110] ...
Acta Biologica Cracoviensia s. Botanica - PAS Journals
... and hair elongation in the presence of Cd2+ were reduced by the ethylene inhibitors CoCl2 at 15 μM and aminooxyacetic acid (AOA ... Encapsulated shoot buds were cultured on onethird- strength MS agar medium (1/3 MS) supplemented with indole-3-butyric acid ( ... 5 EFFECT OF PEA APHID INFESTATION ON ACTIVITY OF AMINO ACID DECARBOXYLASES IN PEA TISSUES ... due to leaching of compounds from callus was encountered and ameliorated through incorporation of 2.84 μM ascorbic acid. Leaf- ...
Picamilon - Nootropics Expert
v] Kuriyama K., Sze P.Y. "Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals" ... xi] Kuriyama K., Sze P.Y. "Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals" ... Picamilon is an analogue of GABA and nicotinic acid (Vitamin B3 or niacin). The addition of niacin allows GABA to cross the ... The nicotinic acid (niacin) in Picamilon boosts blood flow, enhances cell metabolism and oxygen supply in the brain. Resulting ...
Phosphonoacetic Acid | Profiles RNS
"Phosphonoacetic Acid" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Phosphonoacetic Acid" by people in this website by year, and ... Below are the most recent publications written about "Phosphonoacetic Acid" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Phosphonoacetic Acid". ...
Bovine Metabolome Database: Search Results for metabolites
Acetic acid has … Matched name: … Acetic acid … Matched synonyms: … Glacial acetic acid ... Acetic acid glacial ... Acetic acid ... Matched synonyms: … 2-(Aminooxy)acetic acid ... Aminooxy-acetic acid … BMDB0000894. 73122-61-9 ... Matched synonyms: … 2-(3-Pyridyl)acetic acid ... 2-(Pyridin-3-yl)acetic acid ... a-(3-Pyridyl)acetic acid … ... Matched synonyms: … (Dimethylamino)acetic acid ... 2-(Dimethylamino)acetic acid ... 2-(N,N-Dimethylamino)acetic acid … ...
Acetic acid4
- Derivatives of ACETIC ACID which contain an hydroxy group attached to the methyl carbon. (nih.gov)
- Searching metabolites for 'acetic acid' returned 100 results. (bovinedb.ca)
- Acetic acid is a drug which is used to treat infections in the ear canal. (bovinedb.ca)
- Acetic acid exists in all living species, ranging from bacteria to humans. (bovinedb.ca)
GABA2
- Pretreatment with aminooxyacetic acid (AOAA), a GABA transaminase inhibitor, antagonised picrotoxin-induced myoclonus. (who.int)
- Picamilon (nicotinyl-y-aminobutyric acid, or N-nicotinoyl-GABA) is a combination of the inhibitory neurotransmitter GABA with nicotinic acid ( Vitamin B 3 or niacin). (nootropicsexpert.com)
Inhibitor1
- Ethephon (Eth) at various doses will serve as the group of interest and Aminooxyacetic acid (AoA) will act as the ethylene inhibitor. (bibliothequer.com)
Ester2
- t-Boc-aminooxyacetic acid N-hydroxysuccinimide ester is a heterobifunctional linker. (csnpharm.cn)
- Maleimidoacetic acid N-hydroxysuccinimide ester is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules. (csnpharm.cn)
Group1
- 1-Ethoxyethylidene, a New Group for the Stepwise SPPS of Aminooxyacetic Acid Containing Peptides. (univ-grenoble-alpes.fr)
Blood1
- The nicotinic acid (niacin) in Picamilon boosts blood flow, enhances cell metabolism and oxygen supply in the brain. (nootropicsexpert.com)
AOAA2
- Cysteine S-conjugate beta-lyase was inhibited by aminooxyacetic acid (AOAA). (unipr.it)
- Systemic administration of muscimol (2 and 5 mg/kg), THIP (5-15 mg/kg) and aminooxyacetic acid (AOAA) (25 mg/kg) but not baclofen (2.5-15 mg/kg) inhibited the pargyline (65 mg/kg)-induced accumulation of tele-methylhistamine (t-MH). (elsevier.com)
Hydroxylamine4
- Glutamate dehydrogenase activity (GDH) was determined in mouse brain homogenates (1 : 5 w : v on phosphates 0.05 M pH = 7.6 buffer) with different concentrations of pyridoxal phosphate (PPAL), hydroxylamine (OHAMINE) and aminooxyacetic acid (AAOA) with glutamic acid as substrate, using a spectrophotometric method (see Section 2 ). (hindawi.com)
- sodium chloride-hydroxylamine hydrochloride-sulfuric acid solution and Hg (II) is reduced to Hg° with stannous chloride in a continuous flow manifold. (volbyplzensko.cz)
- Synonyms:(Aminooxy)acetic acid hemihydrochloride, Hydroxylamine-O-acetic acid hemihydrochloride, (Carboxymethoxy)amine hemihydrochloride. (volbyplzensko.cz)
- In chemistry, Hydroxylammonium Chloride (HONH 2 -HCl) is an ammonium compound cosisting of a hydrochloric acid salt of hydroxylamine , which may be used to prepare oximes and hydroxmic acids in organic synthesis. (wellnessadvocate.com)
Sodium1
- Soaking discs in various solutions and then treating with carbon dioxide and revealed that deastringency was inhibited by aminooxyacetic acid, sodium cyanide and hot water treatments (70-100℃for 10 min) but not by cycloheximide and Tween-60. (atri.org.tw)
Aminooxy5
- This CAS 2-(Aminooxy)acetic acid World Consumption Report provides data on the net consumption of CAS 645-88-5 - 2-(Aminooxy)acetic acid Substance(s) in each of the countries listed. (researchandmarkets.com)
- The Substance(s) covered (2-(Aminooxy)acetic acid ) are classified by the CAS Registry Number. (researchandmarkets.com)
- Equivalent EINECS: N/A The CAS 2-(Aminooxy)acetic acid World Consumption Reports gives 6 pages of data for each of about 200 countries, plus thousands of database tables and spreadsheets. (researchandmarkets.com)
- This is an entry level product which provides users with commercial intelligence on 2-(Aminooxy)acetic acid markets and industries about 200 countries. (researchandmarkets.com)
- 2-(Aminooxy)acetic acid Market Consumption data is given for each year 1997 to the Current Year and then a forecast to 2028. (researchandmarkets.com)
Salts1
- The liquid phase may be used for further reactions such as oxidations, hydroxamic acid production or neutralization to other hydroxylammonium salts. (volbyplzensko.cz)
Amino acid1
- DCVC, in contrast, was not transported by the organic anion system, but may be transported by one or more amino acid systems. (nih.gov)
Glucose2
- Electrophysiological experiments Rats were killed by decapitation, and the brains were removed and placed into Chrysin 7-O-beta-gentiobioside ice-cold oxygenated sucrose Krebs medium made up of (mM): sucrose 202, KCl 2, KH2PO4 1.25, MgSO4 10, CaCl2 0.5, NaHCO3 26, ascorbic acid 0.5, glucose 10. (recob-tlse.org)
- Slices were then transferred to a recovery chamber kept at room heat and made up of oxygenated Krebs answer (mM): NaCl 124, KCl 2, KH2PO4 1.25, MgSO4 1, CaCl2 2, NaHCO3 26, ascorbic acid 0.5, glucose 10. (recob-tlse.org)
Ethylene1
- The objective of this work was to evaluate the effect of 1-Methylcyclopropene (1-MCP), amino-oxyacetic acid (AOA), and ethylene on the physico-chemical quality of fresh sweet potato and its relationship with fried color score in processed chips of cv. (scielo.org)
Brain2
- Glutamate decarboxylase activity in glial cells and in brain cells was inhibited more than 95% by 1 mm amino-oxyacetic acid. (nih.gov)
- The nicotinic acid (niacin) in Picamilon boosts blood flow, enhances cell metabolism and oxygen supply in the brain. (nootropicsexpert.com)
19971
- 1997). Although not verified experimentally in these studies, XA was assumed to be formed by the irreversible transamination of its immediate bioprecursor 3-HK by the same enzyme(s) that convert the pivotal KP metabolite L-kynurenine to kynurenic acid (Guidetti et al. (recob-tlse.org)
Presence1
- The presence of 2-(fluoromethoxy)3,3,3-trifluoropropanoic acid and 3,3,3-trifluorolactic acid in human urine was confirmed by gas chromatography-mass spectrometry. (asahq.org)
Total1
- This graph shows the total number of publications written about "Peracetic Acid" by people in this website by year, and whether "Peracetic Acid" was a major or minor topic of these publications. (jefferson.edu)
Cell1
- Activities of en- zymes important in neuronal cell metabolism are useful param- eters for following cell maturation and exploring steps in differ- entiation in such cultures. (nih.gov)
Activity2
- After pretreatment of the anesthetized rat with amino-oxyacetic acid (Sigma, 60 mg/kg, i.p.), diazepam partially or totally blocked spontaneous DR activity. (erowid.org)
- A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. (nih.gov)