Aminooxyacetic Acid
4-Aminobutyrate Transaminase
Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
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Reactive Oxygen Species
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Protein Kinase C
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Isoenzymes
Cells, Cultured
Oxidative Stress
LLC-PK1 Cells
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Kidney Tubules, Proximal
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Seeds
Germination
The initial stages of the growth of SEEDS into a SEEDLINGS. The embryonic shoot (plumule) and embryonic PLANT ROOTS (radicle) emerge and grow upwards and downwards respectively. Food reserves for germination come from endosperm tissue within the seed and/or from the seed leaves (COTYLEDON). (Concise Dictionary of Biology, 1990)
Abscisic Acid
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Lepidium sativum
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Saccharomyces cerevisiae Proteins
Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats. (1/114)
cis-3-(9H-Purin-6-ylthio)acrylic acid (PTA) is a structural analog of azathioprine, a prodrug of the antitumor and immunosuppressive drug 6-mercaptopurine (6-MP). In this study, we examined the in vitro and in vivo metabolism of PTA in rats. Two metabolites of PTA, 6-MP and the major metabolite, S-(9H-purin-6-yl)glutathione (PG), were formed in a time- and GSH-dependent manner in vitro. Formation of 6-MP and PG occurred nonenzymatically, but 6-MP formation was enhanced 2- and 7-fold by the addition of liver and kidney homogenates, respectively. Purified rat liver glutathione S-transferases enhanced 6-MP formation from PTA by 1.8-fold, whereas human recombinant alpha, mu, and pi isozymes enhanced 6-MP formation by 1.7-, 1.3-, and 1.3-fold, respectively. In kidney homogenate incubations, PG accumulation was only observed during the first 15 min because of further metabolism by gamma-glutamyltranspeptidase, dipeptidase, and beta-lyase to yield 6-MP, as indicated by the use of the inhibitors acivicin and aminooxyacetic acid. Based on these results and other lines of evidence, two different GSH-dependent pathways are proposed for 6-MP formation: an indirect pathway involving PG formation and further metabolism to 6-MP, and a direct pathway in which PTA acts as a Michael acceptor. HPLC analyses of urine of rats treated i.p. with PTA (100 mg/kg) showed that 6-MP was formed in vivo and excreted in urine without apparent liver or kidney toxicity. Collectively, these studies show that PTA is metabolized to 6-MP both in vitro and in vivo and may therefore be a useful prodrug of 6-MP. (+info)GABA agonists differentially modify blood glucose levels of diabetic rats. (2/114)
This study described the effects of GABA agonists on glucose plasma concentrations of streptozotocin-induced diabetic rats. Low doses of an indirect GABA agonist, AOAA (aminooxyacetic acid); a GABA(A) and a GABA(B) agent, THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridone) and baclofen, respectively; and a benzodiazepine were administered to non-diabetic and to diabetic rats. Plasma glucose concentrations were estimated during fasting and after an oral glucose load. Diazepam (1 mg/kg), baclofen (1 mg/kg) and AOAA (30 mg/kg), significantly decreased glycemia after oral glucose overload of streptozotocin-induced diabetes. None of the GABA-acting agents tested changed fasting or glucose overload glycemia of normal rats. Diazepam was the only drug to increase the fasting blood glucose concentration of diabetic rats. Treatment with AOAA or diazepam was accompanied by increased insulin plasma concentrations in diabetic rats to levels similar to the ones of non-diabetic animals. These results demonstrate that benzodiazepines and other GABA drugs act the endocrine pancreas in vivo, ultimately increasing plasma insulin and decreasing high blood glucose levels of diabetic rats. The acute and prolonged effects of the multitude of drugs acting on the GABA(A)-benzodiazepine-chloride ionophore complex remain to be broadly investigated as a therapeutic tool in diabetes. (+info)Beta-cyanoalanine synthase: purification and characterization. (3/114)
Beta-cyano-L-alanine synthase [L-cysteine hydrogen-sulfide-lyase (adding HCN), EC 4.4.1.9] was purified about 4000-fold from blue lupine seedlings. The enzyme was homoegeneous on gel electrophoresis and free of contamination by other pyridoxal-P-dependent lyases. The enzyme has a molecular weight of 52,000 and contains 1 mole of pyridoxal-P per mole of protein; its isoelectric point is situated at pH 4.7. Its absorption spectrum has two maxima, at 280 and 410 nm. L-Cysteine is the natural primary (amino acid) substrate; beta-chloro- and beta-thiocyano can serve (with considerably lower affinity) instead of cyanide as cosubstrates for cyanoalanine synthase. The synthase is refractory to DL-cycloserine and D-penicillamine, potent inhibitors of many pyridoxal-P-dependent enzymes. Cyanoalanine synthase catalyzes slow isotopic alpha-H exchange in cysteine and in end-product amino acids; the rates of alpha-H exchange in nonreacted (excess) cysteine are markedly increased in the presence of an adequate cosubstrate; no exchange is observed of H atoms in beta-position. (+info)The oscillatory behavior of pancreatic islets from mice with mitochondrial glycerol-3-phosphate dehydrogenase knockout. (4/114)
Glucose stimulation of pancreatic beta cells induces oscillations of the membrane potential, cytosolic Ca(2+) ([Ca(2+)](i)), and insulin secretion. Each of these events depends on glucose metabolism. Both intrinsic oscillations of metabolism and repetitive activation of mitochondrial dehydrogenases by Ca(2+) have been suggested to be decisive for this oscillatory behavior. Among these dehydrogenases, mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), the key enzyme of the glycerol phosphate NADH shuttle, is activated by cytosolic [Ca(2+)](i). In the present study, we compared different types of oscillations in beta cells from wild-type and mGPDH(-/-) mice. In clusters of 5-30 islet cells and in intact islets, 15 mM glucose induced an initial drop of [Ca(2+)](i), followed by an increase in three phases: a marked initial rise, a partial decrease with rapid oscillations and eventually large and slow oscillations. These changes, in particular the frequency of the oscillations and the magnitude of the [Ca(2+)] rise, were similar in wild-type and mGPDH(-/-) mice. Glucose-induced electrical activity (oscillations of the membrane potential with bursts of action potentials) was not altered in mGPDH(-/-) beta cells. In single islets from either type of mouse, insulin secretion strictly followed the changes in [Ca(2+)](i) during imposed oscillations induced by pulses of high K(+) or glucose and during the biphasic elevation induced by sustained stimulation with glucose. An imposed and controlled rise of [Ca(2+)](i) in beta cells similarly increased NAD(P)H fluorescence in control and mGDPH(-/-) islets. Inhibition of the malate-aspartate NADH shuttle with aminooxyacetate only had minor effects in control islets but abolished the electrical, [Ca(2+)](i) and secretory responses in mGPDH(-/-) islets. The results show that the two distinct NADH shuttles play an important but at least partially redundant role in glucose-induced insulin secretion. The oscillatory behavior of beta cells does not depend on the functioning of mGPDH and on metabolic oscillations that would be generated by cyclic activation of this enzyme by Ca(2+). (+info)Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells. (5/114)
Trichloroethylene (Tri) caused modest cytotoxicity in freshly isolated human proximal tubular (hPT) cells, as assessed by significant decreases in lactate dehydrogenase (LDH) activity after 1 h of exposure to 500 microM Tri. Oxidative metabolism of Tri by cytochrome P-450 to form chloral hydrate (CH) was only detectable in kidney microsomes from one patient out of four tested and was not detected in hPT cells. In contrast, GSH conjugation of Tri was detected in cells from every patient tested. The kinetics of Tri metabolism to its GSH conjugate S-(1,2-dichlorovinyl)glutathione (DCVG) followed biphasic kinetics, with apparent Km and Vmax values of 0.51 and 24.9 mM and 0.10 and 1.0 nmol/min per mg protein, respectively. S-(1,2-dichlorovinyl)-L-cysteine (DCVC), the cysteine conjugate metabolite of Tri that is considered the penultimate nephrotoxic species, caused both time- and concentration-dependent increases in LDH release in freshly isolated hPT cells. Preincubation of hPT cells with 0.1 mM aminooxyacetic acid did not protect hPT cells from DCVC-induced cellular injury, suggesting that another enzyme besides the cysteine conjugate beta-lyase may be important in DCVC bioactivation. This study is the first to measure the cytotoxicity and metabolism of Tri and DCVC in freshly isolated cells from the human kidney. These data indicate that the pathway involved in the cytotoxicity and metabolism of Tri in hPT cells is the GSH conjugation pathway and that the cytochrome P-450-dependent pathway has little direct role in renal Tri metabolism in humans. (+info)The effect of culture age, chloramphenicol and B6 inhibitors on intra- and extracellular keto and amino acids of Escherichia coli B. (6/114)
Keto acids and free amino acids were assayed in the cells and the medium of Escherichia coli B growing in the presence of chloramphenicol, cycloserines, aminooxyacetate, and limiting nitrogen source. Under these growth-limiting conditions the cells accumulated ketoglutarate and 'ketovaline' but no other keto acids. In all experiments only ketoglutarate, pyruvate, and 'ketovaline' were found in the medium. Amino acids are released into the medium in the early phases of growth and the composition of the extracellular amino acids is similar to that of the amino acid pool. The concentrations of free amino acids were 10-3-10-4 times higher in the cell than in the medium. The internal pool composition is fixed under all growth-limiting conditions. In the presence of the drugs the cells release amino acids into the medium. (+info)Use of sulfhydryl reagents to investigate branched chain alpha-keto acid transport in mitochondria. (7/114)
The goal of this paper was to determine the contribution of the mitochondrial branched chain aminotransferase (BCATm) to branched chain alpha-keto acid transport within rat heart mitochondria. Isolated heart mitochondria were treated with sulfhydryl reagents of varying permeability, and the data suggest that essential cysteine residues in BCATm are accessible from the cytosolic face of the inner membrane. Treatment with 15 nmol/mg N-ethylmaleimide (NEM) inhibited initial rates of alpha-ketoisocaproate (KIC) uptake in reconstituted mitochondrial detergent extracts by 70% and in the intact organelle by 50%. KIC protected against inhibition suggesting that NEM labeled a cysteine residue that is inaccessible when substrate is bound to the enzyme. Additionally, the apparent mitochondrial equilibrium KIC concentration was decreased 50-60% after NEM labeling, and this difference could not be attributed to effects of NEM on matrix pH or KIC oxidation. In fact, NEM was a better inhibitor of KIC oxidation than rotenone. Measuring matrix aspartate and glutamate levels revealed that the effects of NEM on the steady-state KIC concentration resulted from inhibition of BCATm catalyzed transamination of KIC with matrix glutamate to form leucine. Furthermore, circular dichroism spectra of recombinant human BCATm with liposomes showed that the commercial lipids used in the reconstituted transport assay contain BCAT amino acid substrates. Thus BCATm is distinct from the branched chain alpha-keto acid carrier but may interact with the inner mitochondrial membrane, and it is necessary to inhibit or remove transaminase activity in both intact and reconstituted systems prior to quantifying transport of alpha-keto acids which are transaminase substrates. (+info)Contribution of glutamate dehydrogenase to mitochondrial glutamate metabolism studied by (13)C and (31)P nuclear magnetic resonance. (8/114)
The relative contribution of glutamate dehydrogenase (GDH) and the aminotransferase activity to mitochondrial glutamate metabolism was investigated in dilute suspensions of purified mitochondria from potato (Solanum tuberosum) tubers. Measurements of glutamate-dependent oxygen consumption by mitochondria in different metabolic states were complemented by novel in situ NMR assays of specific enzymes that metabolize glutamate. First, a new assay for aminotransferase activity, based on the exchange of deuterium between deuterated water and glutamate, provided a method for establishing the effectiveness of the aminotransferase inhibitor amino-oxyacetate in situ, and thus allowed the contribution of the aminotransferase activity to glutamate oxidation to be assessed unambiguously. Secondly, the activity of GDH in the mitochondria was monitored in a coupled assay in which glutamine synthetase was used to trap the ammonium released by the oxidative deamination of glutamate. Thirdly, the reversibility of the GDH reaction was investigated by monitoring the isotopic exchange between glutamate and [(15)N]ammonium. These novel approaches show that the oxidative deamination of glutamate can make a significant contribution to mitochondrial glutamate metabolism and that GDH can support the aminotransferases in funneling carbon from glutamate into the TCA cycle. (+info)
Aminooxyacetic acid - Wikipedia
Aminooxyacetic acid hemichloride
TLR2 and TLR4 interact wi… - University of Gothenburg, Sweden
Renal Cysteine Conjugate β-lyase and Compound A Nephrotoxicity | Anesthesiology | American Society of Anesthesiologists
Gluconeogenesis in the kidney cortex. Effects of d-malate and amino-oxyacetate | Biochemical Journal
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Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina.
Bleach & Disinfectants - Cleaning Supplies - Household Products
The oxidation of glutamine and glutamate in relation to anion transport in enterocyte mitochondria | Biochemical Journal
Transport of anionic substrates and glutamate metabolism in mitochondr by M L. Eboli, G Paradies et al.
The malate-aspartate NADH shuttle - NADH Wiki
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SIRT3‐dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth | The...
Man pages for lozalojo/mem
Patient Scheduling Call Center Jobs, Employment in East Amherst, NY | Indeed.com
Malate Aspartate Shuttle - iMedScholar
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An unusual metabolic myopathy: a malate-aspartate shuttle defect. - Nuffield Department of Clinical Neurosciences
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Kynurenine aminotransferase 3/glutamine transaminase L/cysteine conjugate beta-lyase 2 is a major glutamine transaminase in the...
Life | Free Full-Text | Pivotal Enzyme in Glutamate Metabolism of Poly-g-Glutamate-Producing Microbes
Systematic analyses of glutamine and glutamate metabolisms across different cancer types | Cancer Communications | Full Text
lecture14 10 21 08 - Lecture 14 Overview-glycolysis regulation-glucose synthesis-gluconeogenesis regulation Control of the...
Ethylene as a plant hormone
Aminoethoxyvinylglycine (AVG), Aminooxyacetic acid (AOA), and silver salts are ethylene inhibitors. Inhibiting ethylene ... Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme ... SAM is then converted to 1-aminocyclopropane-1-carboxylic acid (ACC) by the enzyme ACC synthase (ACS). The activity of ACS ... Smoke contains ethylene, and once this was realized the smoke was replaced with ethephon or naphthalene acetic acid, which ...
GABA tea
"Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals". Neuropharmacology. 10 (1): ... Sheng-Dun Lin, et al., Bioactive components and antioxidant properties of g-aminobutyric acid (GABA) tea leaves. LWT - Food ... began developing GABA-rich tea in 1984 and successfully produced a new type tea in which almost all glutamic acid has been ... Effect of green tea rich in gamma-aminobutyric acid on blood pressure of Dahl saltsensitive rats. Am J Hypertens. 1995, 8: 74- ...
4-aminobutyrate transaminase
Aminooxyacetic acid Gabaculine Phenelzine Phenylethylidenehydrazine (PEH) Rosmarinic acid Valproic acid Vigabatrin "4- ... As a transaminase, GABA-T's role is to move functional groups from an amino acid and a α-keto acid, and vice versa. In the case ... This succinate will then enter mitochondrion and become part of the citric acid cycle. The critic acid cycle can then produce 2 ... Amino acid residues found in the active site of 4-aminobutyrate transaminase include Lys-329, which are found on each of the ...
GABA transaminase
Inhibitors of the 4-aminobutyrate transaminase isoform include aminooxyacetic acid, gabaculine, phenelzine, ... phenylethylidenehydrazine (PEH), rosmarinic acid, valproic acid and vigabatrin. Some GABA transaminase inhibitors may be used ...
1-aminocyclopropane-1-carboxylate synthase
ACC Synthase is also competitively inhibited by aminoethoxyvinylglycine (AVG) and aminooxyacetic acid (AOA), inhibitors to many ... α-keto-γ-methylthiobutyric acid, and S-adenosylhomocysteine. ACC Synthase is 450-516 amino acid long sequence depending on the ... Aminocyclopropane-1-carboxylic acid synthase (ACC synthase, ACS) (EC 4.4.1.14) is an enzyme that catalyzes the synthesis of 1- ... 1-aminocyclopropane-1-carboxylic acid synthase, 1-aminocyclopropane-1-carboxylate synthetase, aminocyclopropanecarboxylic acid ...
اتیلن - ویکیپدیا، دانشنامهٔ آزاد
Aminoethoxyvinylglycine (AVG), Aminooxyacetic acid (AOA), and silver salts are ethylene inhibitors.[44][45] Inhibiting ethylene ... Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol). *Unsorted benzodiazepine site positive ... Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme ... Ethylene appears to have been discovered by Johann Joachim Becher, who obtained it by heating ethanol with sulfuric acid;[48] ...
C2H5NO3
The molecular formula C2H5NO3 (molar mass: 91.066 g/mol, exact mass: 91.02694 u) may refer to: Aminooxyacetic acid (AOA or AOAA ...
gamma-Aminobutyric acid
Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated ... gamma-Aminobutyric acid, or γ-aminobutyric acid /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, or GABA /ˈɡæbə/, is the chief inhibitory ... Although in chemical terms, GABA is an amino acid (as it has both a primary amine and a carboxylic acid functional group), it ... By convention the term "amino acid", when used without a qualifier, refers specifically to an alpha amino acid. GABA is not an ...
Gamma-Hydroxybutyric acid
Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-gamma-aminobutyric acid in normal and amino oxyacetic acid- ... gamma-Hydroxybutyric acid or γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring ... Beta-Hydroxybutyric acid γ-Hydroxyvaleric acid (GHV) γ-Valerolactone (GVL) Riviello, Ralph J. (2010). Manual of forensic ... May 2003). "A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand". ...
Aminooxyacetic acid
... aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. Aminooxyacetic acid is a general ... I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino- ... Also in 1936, Kitagawa and Takani described the preparation of aminooxyacetic acid by the condensation of benzhydroxamic acid ... and was prepared by the hydrolysis of ethylbenzhydroximinoacetic acid. In 1936, Anchel and Shoenheimer used aminooxyacetic acid ...
Aminooxyacetic acid - Wikipedia
... aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. Aminooxyacetic acid is a general ... I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino- ... Also in 1936, Kitagawa and Takani described the preparation of aminooxyacetic acid by the condensation of benzhydroxamic acid ... and was prepared by the hydrolysis of ethylbenzhydroximinoacetic acid. In 1936, Anchel and Shoenheimer used aminooxyacetic acid ...
Aminooxyacetic acid - DrugBank
... thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem] ... Carboxylic acids. Direct Parent. Carboxylic acids. Alternative Parents. Monocarboxylic acids and derivatives / Organic oxides ... Aminooxyacetic_acid. PDB Entries. 1h0c / 1j04 / 1wyv. Clinical Trials. Clinical Trials Not Available. Pharmacoeconomics. ... Aminooxyacetic acid. Accession Number. DB02079 (EXPT00528) Type. Small Molecule. Groups. Experimental. Description. A compound ...
2-[(2-Phenylquinoline-4-carbonyl)amino]oxyacetic acid | C18H14N2O4 - PubChem
2-[(2-Propoxyacetyl)amino]oxyacetic acid | C7H13NO5 - PubChem
African Journal of Biotechnology - effects of ethylene inhibitors, silver nitrate (agno3), cobalt chloride (cocl2) and...
... or aminooxyacetic acid (AOA) were added to banana culture medium. The highest numbers of shoots per explants shoot length and ... or aminooxyacetic acid (AOA) were added to banana culture medium. The highest numbers of shoots per explants shoot length and ... Effects of ethylene inhibitors, silver nitrate (AgNO3), cobalt chloride (CoCl2) and aminooxyacetic acid (AOA), on in vitro ...
African Journal of Biotechnology - effects of ethylene inhibitors, silver nitrate (agno3), cobalt chloride (cocl2) and...
... or aminooxyacetic acid (AOA) were added to banana culture medium. The highest numbers of shoots per explants shoot length and ... or aminooxyacetic acid (AOA) were added to banana culture medium. The highest numbers of shoots per explants shoot length and ... Effects of ethylene inhibitors, silver nitrate (AgNO3), cobalt chloride (CoCl2) and aminooxyacetic acid (AOA), on in vitro ... Satoh S,Esashi Y (1980). a-Aminoisobutyric acid: A probable competitive inhibitor of conversion of 1 -aminocyclo propane-1 - ...
Aminooxyacetic acid (АОА), inhibitor of 1-aminocyclopropane-1-carboxilic acid (AСС) synthesis, suppresses self-incompatibility...
Aminooxyacetic acid (АОА), inhibitor of 1-aminocyclopropane-1-carboxilic acid (AСС) synthesis, suppresses self-incompatibility- ... Wu L, Williams JS, Wang N, Khatri WA, San Román D, T-h K (2018) Use of domain-swapping to identify candidate amino acids ... Kovaleva LV, Zakharova EV, Voronkov AC, Timofeeva GV, Andreev IM (2017) Role of abscisic acid and ethylene in the control of ... found that preliminary treatment before self-pollination of stigmas of petunia self-incompatible line with aminooxyacetic acid ...
Alfa Aesar™ Bis(Boc-aminooxy)acetic acid, 98% 1g Alfa Aesar™ Bis(Boc-aminooxy)acetic acid, 98%
... acetic acid, 98% 1g Alfa Aesar™ Bis(Boc-aminooxy)acetic acid, 98% Monocarboxylic acids and derivatives ... 1-dimethylethoxy carbonyl amino oxy-acetic acid, bis-boc-aminooxyacetic acid, bis tert-butoxycarbonyl amino oxy acetic acid, ... 1-dimethylethoxy carbonyl amino oxy-acetic acid, bis-boc-aminooxyacetic acid, bis tert-butoxycarbonyl amino oxy acetic acid, ... bis-boc-amino-oxyacetic acid, bis-boc-aoa, bis 1,1-dimethylethoxy carbonyl amino oxy acetic acid, bis 1, ...
Aminooxyacetic acid hemichloride
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam ...
US Patent for Amino thioxomethyl amino oxyacetic acid derivatives Patent (Patent # 6,472,430 issued October 29, 2002) - Justia...
US Patent for Amino thioxomethyl amino oxyacetic acid derivatives Patent (Patent # 6,472,430) Amino thioxomethyl amino ... N-methyl Aminooxy Acetic Acid Hydrochloride (5, R1=Me). A mixture of ethyl N-methyl N-ethoxy carbonyl aminooxy acetate ( ... A solution of N-methyl aminooxy acetic acid hydrochloride (9.5 g) in ethanol (100 mL) was saturated with hydrogen chloride. The ... This invention specifically relates to amino thioxomethyl amino oxyacetic acid derivatives that elevate HDL cholesterol ...
Effects of aminooxyacetic acid on the learning and memory ability and its possible mechanism in rats with chronic alcoholism |...
Alcoholism , Aminooxyacetic Acid , Animals , Hippocampus , Learning , Male , Maze Learning , Memory , Rats , Rats, Sprague- ... Effects of aminooxyacetic acid on the learning and memory ability and its possible mechanism in rats with chronic alcoholism / ... Effects of aminooxyacetic acid on the learning and memory ability and its possible mechani ... [email protected]#To investigate the effects of aminooxyacetic acid (AOAA) on learning and memory ability and possible mechanisms in ...
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Synergistic anticonvulsant action of diazepam & clonazepam with amino-oxyacetic acid against isoniazid-induced convulsions in...
... clonazepam with amino-oxyacetic acid again Synergistic anticonvulsant action of diazepam & clonazepam with amino-oxyacetic acid ... butyric acid (GABA) transaminase inhibitor viz., aminooxyacetic acid (AOAA), and the result was compared with that produced by ... Acetates/therapeutic use , Aminooxyacetic Acid/therapeutic use , Animals , Clonazepam/therapeutic use , Diazepam/therapeutic ... Aminooxyacetic Acid / Isoniazid / Animals Language: English Year: 1989 Type: Article ...
LP Information - press releases - openPR.com
Global "Aminooxyacetic Acid(AOA) Market 2020-2025" Research Report categorizes the global Aminooxyacetic Acid(AOA) market by ... Global Aminooxyacetic Acid(AOA) Market Huge Growth Opportunity between 2020-2025 LP INFORMATION recently released a research ... report on the Aminooxyacetic Acid(AOA) market analysis, which studies the Aminooxyacetic Acid(AOA)s industry coverage, current ... Global "Acid Violet 43 Market 2020-2025" Research Report categorizes the global Acid Violet 43 market by key players, product ...
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... aminooxyacetic acid (AOAC), α-cyano-4-hydroxycinnamic acid (4-HOCA), theonyl-trifluoroacetone (TTFA), and carbonyl cyanide m- ... AOAC, aminooxyacetic acid; AT, α-tocopherol; CCCP, carbonyl cyanide m-chlorophenylhydrazone; DAG, diacylglycerol; DCF-DA, 5-( ... Bicinchoninic acid (BCA) kit was obtained from Pierce. Enhanced chemiluminescence (ECL) and PKC activity kits were purchased ... Kadri-Hassani N, Leger CL, Descomps B: The fatty acid bimodal action on superoxide production by human adherent monocytes under ...
Frontiers | Alternative kynurenic acid synthesis routes studied in the rat cerebellum | Frontiers in Cellular Neuroscience
In tissue homogenates, the non-specific KAT inhibitor aminooxyacetic acid (AOAA; 1 mM) reduced KYNA production from L-KYN and D ... Addition of DAAO inhibitors (benzoic acid, kojic acid or 3-methylpyrazole-5-carboxylic acid; 5 µM each) attenuated KYNA ... Addition of DAAO inhibitors (benzoic acid, kojic acid or 3-methylpyrazole-5-carboxylic acid; 5 µM each) attenuated KYNA ... In tissue homogenates, the non-specific KAT inhibitor aminooxyacetic acid (AOAA; 1 mM) reduced KYNA production from L-KYN and D ...
Glutamate/GABA Synthesis and Metabolism | Sigma-Aldrich
Aminooxyacetic acid (C13408). 3-Mercaptopropionic acid (M5801). γ-Acetylenic GABA (A230). GABA (A2129). │ │---------------→. │ ... Aminooxyacetic acid (C13408). 3-Mercaptopropionic acid (M5801). γ-Vinyl GABA (V8261). GABAculine (A3539). ... Aminooxyacetic acid (C13408). α-Ketoglutarate (m) (K1750). │ │---------------→. ↓. Dicarboxylate carrier. Malate (02300). ... Another problem with amino-oxyacetic acid is that it potently inhibits both glutamate decarboxylase and GABA-transaminase (see ...
α-Tocopherol Decreases Superoxide Anion Release in Human Monocytes Under Hyperglycemic Conditions Via Inhibition of Protein...
... aminooxyacetic acid (AOAC), α-cyano-4-hydroxycinnamic acid (4-HOCA), theonyl-trifluoroacetone (TTFA), and carbonyl cyanide m- ... AOAC, aminooxyacetic acid; AT, α-tocopherol; CCCP, carbonyl cyanide m-chlorophenylhydrazone; DAG, diacylglycerol; DCF-DA, 5-( ... Bicinchoninic acid (BCA) kit was obtained from Pierce. Enhanced chemiluminescence (ECL) and PKC activity kits were purchased ... Kadri-Hassani N, Leger CL, Descomps B: The fatty acid bimodal action on superoxide production by human adherent monocytes under ...
Plus it
... were performed in the presence and absence of aminooxyacetic acid. As shown in Table 3, aminooxyacetic acid was able to ... aminooxyacetic acid. MTT. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. MSeCys. Se-methyl-l-selenocysteine. H2 ... At this concentration aminooxyacetic acid alone had no effect on the cell viability of both cell lines (Fig. 3, A and B). ... Furthermore, 250 μM aminooxyacetic acid, a well known potent inhibitor of PLP-dependent β-lyases, was shown to reduce the ...
Adventitious rooting of conifers: influence of physical and chemical factors | SpringerLink
1-Aminocyclopropane-1-carboxylic acid. AOA. Aminooxyacetic acid. ARF. Adventitious root formation ... De Klerk GJ, Ter Brugge J, Marinova S (1997) Effectiveness of indoleacetic acid, indolebutyric acid and naphthaleneacetic acid ... acetic acid and indole-3-butyric acid on internal levels of the respective auxins and their conjugation with aspartic acid ... Cuttings with indolbutyric acid in five media. Ciênc Rural 29:207-211. doi: 10.1590/S0103-84781999000200004 Google Scholar ...
Excitatory And Inhibitory AAs Flashcards by Amy Hannaford | Brainscape
Frontiers | ABA crosstalk with ethylene and nitric oxide in seed dormancy and germination | Plant Science
It has been clearly demonstrated that dormancy is induced by abscisic acid (ABA) during seed development on the mother plant. ... It has been clearly demonstrated that dormancy is induced by abscisic acid (ABA) during seed development on the mother plant. ... amino-oxyacetic acid), ACO activity (CoCl2; α-AIB: α-aminoisobutyric acid), or ethylene action (2,5 NBD: 2,5-norbornadiene; STS ... ABA, abscisic acid; ABI3, ABA insensitive3; ABI5, ABA insensitive5; ACC, 1-aminocyclopropane 1-carboxylic acid; ACO, ACC ...
000536 - C57BL/6J-Glra1|spd-ot|/J
Ethylene as a plant hormone - Wikipedia
Aminoethoxyvinylglycine (AVG), Aminooxyacetic acid (AOA), and silver salts are ethylene inhibitors. Inhibiting ethylene ... Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme ... SAM is then converted to 1-aminocyclopropane-1-carboxylic acid (ACC) by the enzyme ACC synthase (ACS). The activity of ACS ... Smoke contains ethylene, and once this was realized the smoke was replaced with ethephon or naphthalene acetic acid, which ...
Endogenous preoptic hydrogen sulphide attenuates hypoxia-induced hyperventilation. | CureHunter
Plus it
sodium sulfide
Summary Report | CureHunter
gamma-Aminobutyric acid - Wikipedia
Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated ... gamma-Aminobutyric acid, or γ-aminobutyric acid /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, or GABA /ˈɡæbə/, is the chief inhibitory ... Although in chemical terms, GABA is an amino acid (as it has both a primary amine and a carboxylic acid functional group), it ... By convention the term "amino acid", when used without a qualifier, refers specifically to an alpha amino acid. GABA is not an ...
Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus | Applied and...
The binding of 2-aminooxyacetic acid.AOA, a mimic of β-alanine, is a known inhibitor of aminotransferases (72) and also ... a number of β-amino acids and α-amino acids were tested (Table 1). The results show that VpAT acts exclusively on β-amino acids ... The simplest β-amino acid, β-alanine, occurs in carnosine, coenzyme A, and pantothenic acid. Other β-amino acids are present in ... and 2-aminooxyacetic acid (AOA) were purchased from Sigma-Aldrich. (S)-β-Phenylalanine and (R)-β-phenylalanine were purchased ...
اتیلن - ویکیپدیا، دانشنامهٔ آزاد
Aminoethoxyvinylglycine (AVG), Aminooxyacetic acid (AOA), and silver salts are ethylene inhibitors.[44][45] Inhibiting ethylene ... Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol). *Unsorted benzodiazepine site positive ... Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme ... Ethylene appears to have been discovered by Johann Joachim Becher, who obtained it by heating ethanol with sulfuric acid;[48] ...
AOAAGABAAmino acidsMetabolitesAminooxyGamma-aminInhibitionPreventing ethyleneCarboxylic acidsInhibitorsAsparticSynthesisRatsInhibitInhibitor of pyridoxalGlucuronic acidAspartateAbscisic acidKynurenic acidAminotransferaseEnzymeGlutamic acid decarboxOxyaceticEnergy metabolismNucleic acidsValproic acidPharmacologyKYNAMitochondriaInhibitsNeurotransmitterTransporterProteinGlutamateCompoundsInvestigate the effectsLactic acidHydrochloric acidAnticonvulsant
AOAA3
- Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. (wikipedia.org)
- aminooxyacetic acid (AOAA), and the result was compared with that produced by the two drugs independently. (bvsalud.org)
- During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased. (bvsalud.org)
GABA21
- At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. (wikipedia.org)
- Aminooxyacetic acid is a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes. (wikipedia.org)
- Aminooxyacetic acid was previously used in a clinical trial to reduce symptoms of Huntington's disease by increasing GABA levels in the brain. (wikipedia.org)
- The protective effect of two benzodiazepine compounds , diazepam and clonazepam was tested against isoniazid (INH)- induced convulsions in rats pretreated with the gamma-amino- butyric acid ( GABA ) transaminase inhibitor viz. (bvsalud.org)
- Another problem with amino-oxyacetic acid is that it potently inhibits both glutamate decarboxylase and GABA-transaminase (see Table below). (sigmaaldrich.com)
- It appears that glutamate formed from glutamine may be metabolized in the tricarboxylic acid (TCA) cycle prior to its conversion to GABA, which may allow new alternative regulatory mechanisms. (sigmaaldrich.com)
- However, in the case of the carbonyl-trapping agent aminooxyacetic acid its Ki value for inhibition of GABA-transaminase is 10-fold lower than that for glutamate decarboxylase. (sigmaaldrich.com)
- Gamma-aminobutyric acid (GABA) regulation of anion flux through ALMT proteins requires a specific amino acid motif in ALMTs that shares similarity with a GABA binding site in mammalian GABA A receptors. (plantcell.org)
- It acts by inhibiting reuptake at the gamma-aminobutyric acid (GABA) transporter (GAT-1). (springer.com)
- Glutamic acid decarboxylase 65, 67, and GABA-transaminase mRNA expression and total enzyme activity in the goldfish (Carassius auratus) brain. (nih.gov)
- There were region-specific changes of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD), with increased GAD-67-immunopositive interneurons in the stratum oriens of the CA1 region of the hippocampus, accompanied by nonsignificant reduction of GAD-67 synapses in the CA3 region. (jneurosci.org)
- γ-aminobutyric acid (GABA) is intimately involved in basal ganglia function. (scirp.org)
- Our previous study using a unilaterally lesioned rat model of PD indicated that elevating GABA levels by GABA transaminase inhibitor, aminooxyacetic acid significantly attenuated L-DOPA-induced ERK phosphorylation in the striatum and substantia nigra (SN). (scirp.org)
- Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian brain (Roberts et al. (psychiatrictimes.com)
- Gamma-aminobutyric acid is synthesized by decarboxylation of glutamate by cytosolic glutamic acid decarboxylase (GAD) and is metabolized by the mitochondrial enzyme GABA-transaminase (GABA-T) to succinic semialdehyde, which in turn can enter the Krebs cycle to ultimately regenerate glutamate. (psychiatrictimes.com)
- GAT-1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft. (thefullwiki.org)
- The invention concerns a method for treating depression or senile dementia using a compound which acts selectively as an agonist of gamma aminobutyric acid (GABA) at GABA autoreceptors with the proviso that the compound is not fengabine and progabide. (justia.com)
- Among these acute effects are a marked change in the release, synthesis and level of gamma aminobutyric acid (GABA) in the brain. (justia.com)
- GABA (Gamma-AminoButyric Acid) is an inhibitory neurotransmitter that has a calming and relaxing effect in the brain. (drjockers.com)
- Our gut microbiome plays an important role with GABA production and helps to convert glutamine and glutamic acid into GABA. (drjockers.com)
- GABA is synthesized from the amino acid glutamate with the enzyme glutamate decarboxylase (GAD) and pyridoxal phosphate (which is the activated form of vitamin B6) as the key cofactor. (drjockers.com)
Amino acids17
- Various nonproteinogenic β-amino acids occur naturally as free metabolites and as components of biosynthetic products ( 1 ). (asm.org)
- Other β-amino acids are present in bioactive peptides, such as the protease inhibitor bestatin, which contains a (2 S ,3 R )-3-amino-2-hydroxy-4-phenylbutanoyl group, and microcystin, a cyclic nonribosomal peptide that acts as a phosphatase inhibitor and contains both an aliphatic and an aromatic β-amino acid moiety ( 2 - 4 ). (asm.org)
- Other β-amino acids occur as building blocks in β-lactam antibiotics ( 4 , 7 ) and in antifungal compounds, such as jasplakinolide ( 8 ). (asm.org)
- Various amino acids were found to inhibit both brain and liver AspD. (nus.edu.sg)
- Balcar, V.J., 2002, Molecular pharmacology of the Na + -dependent transport of acidic amino acids in the mammalian central nervous system. (springer.com)
- This was done using only natural amino acids, thereby allowing for both synthetic and recombinant production. (diva-portal.org)
- An easy fluorimetric assay for measuring D-amino acid oxidase (DAAO) activity by using one of the D-amino acids - D-kynurenine (D-KYN) - as a substrate was applied to assess DAAO activity in the cerebrum, cerebellum, and brainstem of Sprague-Dawley (SD) male rats. (go.jp)
- Some cancers are attracted to glutamine, one of the 20 common amino acids that code for a genetic sequence or code. (wikibooks.org)
- In fact, glutamine plays an important role in up-taking essential amino acids and activating TOR kinase, which is a specific enzyme that is necessary for balancing protein synthesis and degradation. (wikibooks.org)
- Typically these compounds are in the form of nucleotides and essential amino acids. (wikibooks.org)
- Glutamic acid becomes the primary donor of nitrogen for synthesizing nonessential amino acids. (wikibooks.org)
- Transaminases are specific enzyme that aid in transferring the amino group of glutamic acid to α-ketoacids which are used to create nonessential amino acids. (wikibooks.org)
- Through the study of yeast, it was concluded that there needs to be a sufficient level of amino acids for TORC1 to be properly activated. (wikibooks.org)
- Studies of cell lines of mTORC1 showed that cells depended not only on the presence of essential amino acids but also glutamine at the same time. (wikibooks.org)
- From studying how glutamine is taken up through an importer called SLC1A5 showed that glutamine was exported using SLC7A5 which exchanges glutamine for uptake of essential amino acids. (wikibooks.org)
- Additionally, glutamine serves as an important nitrogen donor for assembly of amino acids, nucleotides and nicotinamide. (biomedcentral.com)
- In protein science , an Imino Acid (Secondary Amino Acid) is a molecule, related to amino acids (differing in the bonding to the nitrogen), that contains both an imino (>C=NH) and a carboxyl (-C(=O)-OH) functional group, which occurs as either an acyclic acid or a cyclic imino acid . (wellnessadvocate.com)
Metabolites4
- quinolinic acid (QUIN)] and neuroprotective [kynurenic acid (KYNA)] KP metabolites. (pnas.org)
- Because of this, cancer cells can then secrete extra glycolytic metabolites in the from of lactic acid. (wikibooks.org)
- In addition, the histopathological result was consistent with that of the serum metabolomic analysis, and the changes in serum metabolites in each sausage diet group and the NDMA group were consistently associated with disorders of lipids, amino acid, and energy metabolism. (foodandnutritionresearch.net)
- The mitochondrial tricarboxylic acid cycle (TCA cycle) provides additional metabolites that funnel into lipid, amino acid and nucleotide synthesis. (biomedcentral.com)
Aminooxy6
- Bis(Boc-aminooxy)acetic acid employed as a protecting reagent and intermediate pharmaceuticals and chemical research. (fishersci.dk)
- In this study, experiments were conducted both in vitro (using cell cultures) and in vivo (using mice) to test the effect of a chemical compound called " (aminooxy)acetic acid " (AOA). (medicalnewstoday.com)
- The phytotoxicity of acifluorfen and oxyfluorfen [2-chloro-l-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene] to spinach is counteracted by appropriate treatments with (aminooxy)acetic acid, L-2-(aminooxy)-3-phenylpropionic acid, or silver nitrate and by heat shock. (elsevier.com)
- Under certain conditions soybean injury is ameliorated by combining (aminooxy)acetic acid with acifluorfen and silver nitrate with oxyfluorfen. (elsevier.com)
- Complete submergence of rice plants under water for 10 days in presence of an ethylene-biosynthetic inhibitor, aminooxy acetic acid (AOA), resulted in appreciable lowering of lodging during post-submergence period when compared with plants submerged without AOA. (bdsbmb.org)
- Aminooxy acetic acid (AOA) - chilling-chlorophyll-ethylene- gibberellic acid (GA) - germination-lodging - submergence. (bdsbmb.org)
Gamma-amin12
- A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. (drugbank.ca)
- The level of GAD67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels. (nih.gov)
- Effects of increased gamma-aminobutyric acid levels on GAD67 protein and mRNA levels in rat cerebral cortex. (nih.gov)
- Choi, S. and Silverman, R.B., 2002, Inactivation and inhibition of gamma-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues. (springer.com)
- The Emerging Role of GABAergic Mechanisms in Mood Disorders by Po W. Wang, M.D., and Terence A. Ketter, M.D. Gamma-aminobutyric acid is a major inhibitory neurotransmitter widely distributed in the mammalian central nervous system. (psychiatrictimes.com)
- Gamma-aminobutyric acid binds to neuronal and glial recognition sites. (psychiatrictimes.com)
- The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain. (thefullwiki.org)
- Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition. (thefullwiki.org)
- 1998). "Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex. (thefullwiki.org)
- Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation. (thefullwiki.org)
- Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes. (thefullwiki.org)
- The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV. (thefullwiki.org)
Inhibition5
- Also, the inhibition of aspartate aminotransferase by aminooxyacetic acid has clinical implications for the treatment of breast cancer, since a decrease in glycolysis disrupts breast adenocarcinoma cells more than normal cells. (wikipedia.org)
- Moreover, selective inhibition of aspartate aminotransferase with aminooxyacetic acid ameliorated experimental autoimmune encephalomyelitis in a therapeutic mouse model by reprograming the differentiation of pro-inflammatory T helper 17 cells, that boost the immune system, towards induced anti-inflammatory regulatory T cells. (wikipedia.org)
- Papapetropoulos A, Zhou J, Hellmich MR, Szabo C. ( 2016 ) Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach. (utmb.edu)
- It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with. (drugbank.ca)
- Its pharmacological effect is thought to be mediated through inhibition of the enzyme cyclooxygenase (COX), the enzyme responsible for catalyzes the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway. (drugbank.ca)
Preventing ethylene1
- Aminooxyacetic acid can also inhibit 1-aminocyclopropane-1-carboxylate synthase preventing ethylene synthesis, which can increase the vase life of cut flowers. (wikipedia.org)
Carboxylic acids3
- This compound belongs to the class of organic compounds known as carboxylic acids. (drugbank.ca)
- ureidooxy carboxylic acids (3) and their derivatives as plant growth regulators and herbicides. (justia.com)
- In organic chemistry , Acyclic Acids (Ethanoic Acids) , as organic compounds are 2 carbon straight-chain saturated carboxylic acids , that have an open-chain molecular structures as opposed to ring-shaped structures. (wellnessadvocate.com)
Inhibitors4
- effects of ethylene inhibitors, silver nitrate (agno3), cobalt chloride (cocl2) and aminooxyacetic acid (aoa), on in vitro shoot induction and rooting of banana (musa acuminata l. (academicjournals.org)
- Expression of CsHA1 , CsFRO1 , and CsIRT1 is diminished in Fe-deficient roots by treatment with ethylene inhibitors, such as Co (cobalt) or AOA (aminooxyacetic acid). (unl.edu)
- The addition of specific DAAO inhibitors, such as 3-methylpyrazole-5-carboxylic acid and 4 H -thieno [3, 2-b] pyrrole-5-carboxylic acid (Compound 8), significantly attenuated the fluorescence intensity of KYNA, suggesting that DAAO present in the rat brain homogenates was responsible for the production of KYNA. (go.jp)
- However relaxation responses were reduced by L-NNA (100 µM) an inhibitor of nitric oxide (NO) synthesis (40-50% reduction), zinc protoprophyrin IX (10 µM) an inhibitor of carbon monoxide (CO) synthesis (20-40% reduction) and also propargylglycine (30 µM) and aminooxyacetic acid (30 µM), inhibitors of hydrogen sulphide (H2S) synthesis (15-20% reduction). (edu.au)
Aspartic1
- The perception of this gaseous two-carbon hormone is achieved by a group of membrane-associated dimeric ethylene receptors that resemble bacterial two-component signaling systems and are composed of hybrid histidine (or aspartic acid) kinases, a histidine-containing phosphor-transfer domain, and response regulators ( 2 ). (mcponline.org)
Synthesis4
- It was found that preliminary treatment before self-pollination of stigmas of petunia self-incompatible line with aminooxyacetic acid (AOA), inhibitor of ACC synthesis, led to stimulation of pollen tubes growth when the latter did not exhibit any hallmarks of PCD. (springer.com)
- ACC synthesis increases with high levels of auxins, especially indole acetic acid (IAA) and cytokinins. (wikipedia.org)
- 3 R )-3-[(1 R )-1-( tert -Butyldimethylsilyl)oxy-1-(2-methoxy-4,5-methylenedioxyphenyl)methyl]-2-methylene-4-butanolide, which is a key intermediate for the synthesis of 1,2-oxidized furofuran lignan, was stereoselectively synthesized from L -glutamic acid by applying direct methylenation to butanolide. (go.jp)
- c) treatment with H2S synthesis inhibitor aminooxyacetic acid (ΑΟΑΑ) or propargylglycine (PAG) and d) H2S donor sodium thiosulfate (STS) or GYY3147. (bvsalud.org)
Rats3
- Synergistic anticonvulsant action of diazepam & clonazepam with amino-oxyacetic acid against isoniazid-induced convulsions in rats. (bvsalud.org)
- 2019 ) Effects of aminooxyacetic acid on hippocampal mitochondria in rats with chronic alcoholism: the analysis of learning and memory-related genes. (academictree.org)
- Behavioral and pharmacological effects of centrally administered aminooxyacetic acid in rats. (cookleave.info)
Inhibit2
- This is particularly serious for aminooxyacetic acid, which at high concentrations will inhibit all pyridoxal phosphate-dependent enzymes. (sigmaaldrich.com)
- however, the article published in Anesthesiology, January 1997, clearly showed that aminooxyacetic acid did not inhibit compound A-mediated renal necrosis or glucosuria, a finding suggesting that pathways of metabolism other than that mediated by renal cysteine conjugate [small beta, Greek]-lyase contributed to the nephrotoxicity of compound A. (asahq.org)
Inhibitor of pyridoxal1
- The protective activity against cisplatin-induced cytotoxicity and ROS generation was blocked by aminooxyacetic acid, a selective inhibitor of pyridoxal 5′-phosphate-dependent cysteine conjugate β-lyases, further supporting the role of β-lyase in the observed chemoprotection. (aspetjournals.org)
Glucuronic acid1
- The invention is also directed to the use of the receptor for diagnostics of Helicobacter pylori, to a method of producing chondroitin oligosaccharides from chondroitin sulphates, and a method for production of amidated glucuronic acid comprising oligosaccharides and monosaccharides from glucuronic acid comprising polysaccharides. (sumobrain.com)
Aspartate2
- Aminooxyacetic acid inhibits aspartate aminotransferase, another PLP-dependent enzyme, which is an essential part of the malate-aspartate shuttle. (wikipedia.org)
- Some examples of α-ketoacids include pyruvate, oxaloacetate, or gamma-semialdehyde which are also used to synthesize nonessential acids such as alanine, serine or aspartate. (wikibooks.org)
Abscisic acid4
- It has been clearly demonstrated that dormancy is induced by abscisic acid (ABA) during seed development on the mother plant. (frontiersin.org)
- Plant senescence is regulated by a coordinated genetic program mediated in part by changes in ethylene, abscisic acid (ABA), and cytokinin content. (plantphysiol.org)
- Senescence is accompanied by changes in endogenous ethylene, abscisic acid (ABA), and cytokinins, and these changes are believed to mediate signaling events that control the process. (plantphysiol.org)
- The plant growth regulator abscisic acid (ABA) can cause physiological responses that protect plants against CI or LTI. (core.ac.uk)
Kynurenic acid2
- Kynurenic acid (KYNA), an astrocyte-derived, endogenous antagonist of α7 nicotinic acetylcholine and excitatory amino acid receptors, regulates glutamatergic, GABAergic, cholinergic and dopaminergic neurotransmission in several regions of the rodent brain. (frontiersin.org)
- In this assay, DAAO produces kynurenic acid (KYNA) from D-KYN, and the fluorescence originating from KYNA can then be used to evaluate DAAO activity. (go.jp)
Aminotransferase3
- The crystal structure was used to rationalize the stereo- and regioselectivity of V. paradoxus aminotransferase and to define a sequence motif with which new aromatic β-amino acid-converting aminotransferases may be identified. (asm.org)
- Bixel, M.G., Hutson, S.M. and Hamprecht, B., 1997, Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture. (springer.com)
- In contrast, an inhibitor of aminotransferase (AT), aminooxyacetic acid, did not decrease KYNA production from D-KYN, meaning that AT could not metabolize D-KYN to KYNA under the present conditions. (go.jp)
Enzyme2
- Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme Met adenosyltransferase. (wikipedia.org)
- SAM is then converted to 1-aminocyclopropane-1-carboxylic acid (ACC) by the enzyme ACC synthase (ACS). (wikipedia.org)
Glutamic acid decarbox1
- Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. (nih.gov)
Oxyacetic1
- This invention specifically relates to amino thioxomethyl amino oxyacetic acid derivatives that elevate HDL cholesterol concentration and which may be useful for the treatment of atherosclerotic conditions such as, coronary heart disease. (justia.com)
Energy metabolism1
- Aminooxyacetic acid has been shown to cause excitotoxic lesions of the striatum, similar to Huntington's disease, potentially due to its impairment of mitochondrial energy metabolism. (wikipedia.org)
Nucleic acids1
- The medium was evaluated for its ability to support growth of the yeast phase of P. brasiliensis at 37 °C. Cultures were followed for 240 h and growth patterns were determined by measuring optical density, dry weight, nucleic acids and protein. (microbiologyresearch.org)
Valproic acid1
- The present study was undertaken to investigate the effect of established anticonvulsants, such as valproic acid, carbamazepine, gabapentin, diazepam, lacosamide and pregabalin against pentylenetetrazole (6 mM) seizures in adult zebrafish. (ijpsonline.com)
Pharmacology2
- Kuhse, J., Schmieden, V. & Betz, H. A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit. (nature.com)
- Schmieden, V., Kuhse, J. & Betz, H. Agonist pharmacology of neonatal and adult glycine receptor α subunits: identification of amino acid residues involved in taurine activation. (nature.com)
KYNA1
- However, alternative routes, including KYNA formation from D-kynurenine (D-KYN) by D-amino acid oxidase (DAAO) and the direct transformation of kynurenine to KYNA by reactive oxygen species (ROS), have been demonstrated in the rat brain. (frontiersin.org)
Mitochondria1
- Also in the nerve terminals, aminooxyacetic acid prevents the mitochondria from utilizing pyruvate generated from glycolysis, thus leading to a bioenergetic state similar to that of hypoglycemia. (wikipedia.org)
Inhibits1
- mTORC1 is typically a major regulator of cell growth and activates protein translation but inhibits the response of macrophages to excess amino acid production. (wikibooks.org)
Neurotransmitter1
- Mice lacking the neuronal NOS (nNOS) isoform have a phenotype that could be explained by decreased availability of glutamate, an amino acid that is also an excitatory neurotransmitter. (sciencemag.org)
Transporter1
- Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. (drugbank.ca)
Protein1
- By grafting the amino acid sequence -GSECG to the C-terminal of our model-protein, a HER2-binding Affibody molecule, we enabled site specific labeling with both trivalent radiometals and with 99m Tc. (diva-portal.org)
Glutamate1
- Glutamate is derived from and can be converted to glutamine, and oxidation of glutamate feeds into the energy-providing TCA (tricarboxylic acid) cycle. (sciencemag.org)
Compounds3
- These are compounds containing a carboxylic acid group with the formula -C(=O)OH. (drugbank.ca)
- Among the compounds disclosed is 5-chloro-2-methylphenyl thioureido acetic acid (2). (justia.com)
- In view of the growing importance of pharmaceutical compounds containing β-amino acid groups, there is demand for new tools for their production in enantiopure form. (asm.org)
Investigate the effects1
- The objective of this study was to investigate the effects of amino acid compositions and their concentration on the Bt toxin content in Bt cotton to gain a better physiological understanding of the observed phenomenon. (usda.gov)
Lactic acid1
- It has been studied by Otto Warburg, a notable German physiologist and Nobel Laureate, that cancer cells seem to uptake more glucose and produce more lactic acid than regular cells or tissues. (wikibooks.org)
Hydrochloric acid1
- Also in 1936, Kitagawa and Takani described the preparation of aminooxyacetic acid by the condensation of benzhydroxamic acid and ethyl bromoacetate, followed by hydrolysis by hydrochloric acid. (wikipedia.org)
Anticonvulsant1
- Aminooxyacetic acid also has anticonvulsant properties. (wikipedia.org)