Aminoimidazole Carboxamide
Glutamate Formimidoyltransferase
Phosphoribosylaminoimidazolecarboxamide Formyltransferase
Hydroxymethyl and Formyl Transferases
Ribonucleotides
Carbon-Nitrogen Ligases
Phosphoribosylglycinamide Formyltransferase
Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor
Agelas
Purines
Imidazoles
Carboxy-Lyases
Ligases
Salmonella enterica
Ribonucleosides
Amino Acid Sequence
AMP-Activated Protein Kinases
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
Adenylate Kinase
Phenformin
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
GTP Cyclohydrolase
(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
Glucose
Muscle, Skeletal
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Glucose Clamp Technique
Tubercidin
Folate Receptor 1
Folate Receptors, GPI-Anchored
Reduced Folate Carrier Protein
Uveitis
Retinol-Binding Proteins
Proteins which bind with RETINOL. The retinol-binding protein found in plasma has an alpha-1 mobility on electrophoresis and a molecular weight of about 21 kDa. The retinol-protein complex (MW=80-90 kDa) circulates in plasma in the form of a protein-protein complex with prealbumin. The retinol-binding protein found in tissue has a molecular weight of 14 kDa and carries retinol as a non-covalently-bound ligand.
Base Sequence
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Constipation
Serotonin Agents
Clinical Trials, Phase IV as Topic
Planned post-marketing studies of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale. These studies are often conducted to obtain additional data about the safety and efficacy of a product. This concept includes phase IV studies conducted in both the U.S. and in other countries.
Ritanserin
Quipazine
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Laxatives
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
RNA Polymerase II
Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer. (1/623)
The purpose of this study is to characterize the absorption, metabolism, and excretion of carbon 14-labeled temozolomide (14C-TMZ) administered p.o. to adult patients with advanced solid malignancies. On day 1 of cycle 1, six patients received a single oral 200-mg dose of 14C-TMZ (70.2 microCi). Whole blood, plasma, urine, and feces were collected from days 1-8 and on day 14 of cycle 1. Total radioactivity was measured in all samples. TMZ, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC), and 4-amino-5-imidazole-carboxamide (AIC) concentrations were determined in plasma, and urine and plasma samples were profiled for metabolite/degradation products. Maximum TMZ plasma concentrations were achieved between 0.33 to 2 h (mean, 1.2 h), and half-life, apparent volume of distribution, and oral clearance values averaged 1.9 h, 17 liters/m2, and 104 ml/min/m2, respectively. A first-order absorption, one-compartment linear model, which included first-order formation of MTIC from TMZ and elimination of MTIC via degradation to AIC, and a peripheral distribution compartment for AIC, adequately described the plasma TMZ, MTIC, and AIC concentrations. MTIC systemic clearance was estimated to be 5384 ml/min/m2, and the half-life was calculated to be 2.5 min. Metabolite profiles of plasma at 1 and 4 h after treatment showed that 14C-derived radioactivity was primarily associated with TMZ, and a smaller amount was attributed to AIC. Profiles of urine samples from 0-24 h revealed that 14C-TMZ-derived urinary radioactivity was primarily associated with unchanged drug (5.6%), AIC (12%), or 3-methyl-2,3-dihydro-4-oxoimidazo[5,1-d]tetrazine-8-carboxyl ic acid (2.3%). The recovered radioactive dose (39%) was principally eliminated in the urine (38%), and a small amount (0.8%) was excreted in the feces. TMZ exhibits rapid oral absorption and high systemic availability. The primary elimination pathway for TMZ is by pH-dependent degradation to MTIC and further degradation to AIC. Incomplete recovery of radioactivity may be explained by the incorporation of AIC into nucleic acids. (+info)Apoptosis induced by growth factor withdrawal in fibroblasts overproducing fructose 2,6-bisphosphate. (2/623)
Fructose 2,6-bisphosphate is a potent endogenous stimulator of glycolysis. A high aerobic glycolytic rate often correlates with increased cell proliferation. To investigate this relationship, we have produced clonal cell lines of Rat-1 fibroblasts that stably express transgenes coding for 6-phosphofructo-2-kinase, which catalyzes the synthesis of fructose 2,6-bisphosphate, or for fructose 2,6-bisphosphatase, which catalyzes its degradation. While serum deprivation in culture reduced the growth rate of control cells, it caused apoptosis in cells overproducing fructose 2,6-bisphosphate. Apoptosis was inhibited by 5-amino-4-imidazolecarboxamide riboside, suggesting that 5'-AMP-activated protein kinase interferes with this phenomenon. (+info)Effect of AMPK activation on muscle glucose metabolism in conscious rats. (3/623)
The effect of AMP-activated protein kinase (AMPK) activation on skeletal muscle glucose metabolism was examined in awake rats by infusing them with 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR; 40 mg/kg bolus and 7.5 mg. kg-1. min-1 constant infusion) along with a variable infusion of glucose (49.1 +/- 2.4 micromol. kg-1. min-1) to maintain euglycemia. Activation of AMPK by AICAR caused 2-deoxy-D-[1,2-3H]glucose (2-DG) uptake to increase more than twofold in the soleus and the lateral and medial gastrocnemius compared with saline infusion and occurred without phosphatidylinositol 3-kinase activation. Glucose uptake was also assessed in vitro by use of the epitrochlearis muscle incubated either with AICAR (0.5 mM) or insulin (20 mU/ml) or both in the presence or absence of wortmannin (1.0 microM). AICAR and insulin increased muscle 2-DG uptake rates by approximately 2- and 2.7-fold, respectively, compared with basal rates. Combining AICAR and insulin led to a fully additive effect on muscle glucose transport activity. Wortmannin inhibited insulin-stimulated glucose uptake. However, neither wortmannin nor 8-(p-sulfophenyl)-theophylline (10 microM), an adenosine receptor antagonist, inhibited the AICAR-induced activation of glucose uptake. Electrical stimulation led to an about threefold increase in glucose uptake over basal rates, whereas no additive effect was found when AICAR and contractions were combined. In conclusion, the activation of AMPK by AICAR increases skeletal muscle glucose transport activity both in vivo and in vitro. This cellular pathway may play an important role in exercise-induced increase in glucose transport activity. (+info)5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. (4/623)
It has previously been reported that exercise causes an increase in glucose uptake in skeletal muscle and also an increase in 5' AMP-activated protein kinase (AMPK) activity. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICA-riboside), an analog of adenosine, is taken up into cells and phosphorylated to form AICA-riboside monophosphate (ZMP), which can also activate AMPK. This study was designed to determine whether the increase in glucose uptake observed with AMPK activation by AICA-riboside is due to GLUT4 translocation from an intracellular location to the plasma membranes, similar to that seen in response to contraction. Rat hindlimbs were perfused with Krebs-Henseleit bicarbonate containing 4% bovine serum albumin, washed bovine erythrocytes, 8 mmol/l glucose, and +/-2 mmol/AICA-riboside or +/-60 nmol/l insulin. Perfusion medium containing AICA-riboside was found to significantly increase AMPK activity, glucose uptake, and GLUT4 translocation in skeletal muscle above basal levels. Insulin-perfused muscles showed significant increases in glucose uptake and GLUT4 translocation, but AMPK activation was not significantly changed from basal levels. These results provide evidence that the increased glucose uptake observed with AMPK activation by AICA-riboside in perfused rat hindlimb muscles is due to an increase in the translocation of GLUT4 to surface membranes. (+info)Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. (5/623)
Insulin increases glucose uptake through the translocation of GLUT-4 via a pathway mediated by phosphatidylinositol 3-kinase (PI3K). In contrast, myocardial glucose uptake during ischemia and hypoxia is stimulated by the translocation of GLUT-4 to the surface of cardiac myocytes through a PI3K-independent pathway that has not been characterized. AMP-activated protein kinase (AMPK) activity is also increased by myocardial ischemia, and we examined whether AMPK stimulates glucose uptake and GLUT-4 translocation. In isolated rat ventricular papillary muscles, 5-aminoimidazole-4-carboxyamide-1-beta-D-ribofuranoside (AICAR), an activator of AMPK, as well as cyanide-induced chemical hypoxia and insulin, increased 2-[(3)H]deoxyglucose uptake two- to threefold. Wortmannin, a PI3K inhibitor, did not affect either the AICAR- or the cyanide-stimulated increase in deoxyglucose uptake but eliminated the insulin-stimulated increase in deoxyglucose uptake. Immunofluorescence studies demonstrated translocation of GLUT-4 to the myocyte sarcolemma in response to stimulation with AICAR, cyanide, or insulin. Preincubation of papillary muscles with the kinase inhibitor iodotubercidin or adenine 9-beta-D-arabinofuranoside (araA), a precursor of araATP (a competitive inhibitor of AMPK), decreased AICAR- and cyanide-stimulated glucose uptake but did not affect basal or insulin-stimulated glucose uptake. In vivo infusion of AICAR caused myocardial AMPK activation and GLUT-4 translocation in the rat. We conclude that AMPK activation increases cardiac muscle glucose uptake through translocation of GLUT-4 via a pathway that is independent of PI3K. These findings suggest that AMPK activation may be important in ischemia-induced translocation of GLUT-4 in the heart. (+info)Improvement by 5-amino-4-imidazole carboxamide riboside of the contractile dysfunction that follows brief periods of ischemia through increases in ecto-5-nucleotidase activity and adenosine release in canine hearts. (6/623)
5-Amino-4-imidazole carboxamide (AICA) riboside increases adenosine release in ischemic myocardium, suggesting that AICA riboside improves contractile dysfunction. In 49 open-chest dogs, contractile function assessed by fractional shortening (FS) was observed 3 h after the onset of reperfusion following 15 min of occlusion of the left anterior descending coronary artery. During reperfusion, the treatment with AICA riboside increased adenosine concentration in the coronary venous blood (536+/-44 vs. 281+/-21 pmol/ml at 3 min of reperfusion, p<0.001) and peak coronary hyperemic flow (367+/-13 vs. 300+/-21 ml/100 g per min, p<0.001) when compared with the untreated group. FS at 3h of reperfusion increased in the AICA riboside group (21.1+/-2.3 vs. 12.8+/-0.6% in the untreated group, p<0.001). AICA riboside increased myocardial ecto-5'-nucleotidase activity. Administration of adenosine also augmented coronary hyperemic flow and increased FS to the levels of the AICA riboside group. Either 8-phenyltheophylline (an antagonist of adenosine receptors) or alpha,beta-methylene-adenosine 5'-diphosphate (an inhibitor of ecto-5'-nucleotidase) completely abolished the increased coronary hyperemic flow and improvements of myocardial contractile function due to AICA riboside. Thus it was concluded that AICA riboside improves the contractile dysfunction that follows a brief period of ischemia via adenosine-dependent mechanisms. (+info)Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis. (7/623)
OBJECTIVE: The mechanism of anti-inflammatory effects of methotrexate (MTX) at low dose may relate to a decrease in availability of the purine precursor or it may depend on accumulation of 5-aminoimidazole-4-carboxamide (AICAR) and the anti-inflammatory nucleoside adenosine. The aim of this study was to evaluate the possible mechanism of action by analysis of changes in blood concentrations of purine and pyrimidine metabolites during MTX treatment. METHODS: Venous blood samples were collected from rheumatoid arthritis patients before and at different times for up to 7 days after the start of MTX treatment. Whole blood concentrations of adenosine, uridine, hypoxanthine, uric acid and erythrocyte nucleotides were measured by HPLC. RESULTS: The initial blood adenosine concentration was 0.073 +/- 0.013 microM and no differences were observed during MTX treatment. However, a decrease in uric acid concentration was observed from 205.5+/-13.5 to 160. 9+/-13.5 microM (P<0.05) within 24 h after MTX administration. The hypoxanthine concentration decreased in parallel with uric acid, while the uridine concentration decreased 48 h after MTX administration. No accumulation of AICAR-triphosphate (ZTP) was observed in the erythrocytes. CONCLUSIONS: MTX decreases circulating purine and pyrimidine concentrations, and their availability for DNA and RNA synthesis, which may affect immune cell proliferation and protein (cytokine) expression. The absence of adenosine concentration changes and lack of ZTP formation is evidence against an AICAR/adenosine mechanism, although localized adenosine concentration changes cannot be excluded. (+info)Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. (8/623)
This study was designed to determine whether chronic chemical activation of AMP-activated protein kinase (AMPK) would increase glucose transporter GLUT-4 and hexokinase in muscles similarly to periodic elevation of AMPK that accompanies endurance exercise training. The adenosine analog, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), has previously been shown to be taken up by cells and phosphorylated to form a compound (5-aminoimidazole-4-carboxamide ribonucleotide) that mimics the effect of AMP on AMPK. A single injection of AICAR resulted in a marked increase in AMPK in epitrochlearis and gastrocnemius/plantaris muscles 60 min later. When rats were injected with AICAR (1 mg/g body wt) for 5 days in succession and were killed 1 day after the last injection, GLUT-4 was increased by 100% in epitrochlearis muscle and by 60% in gastrocnemius muscle in response to AICAR. Hexokinase was also increased approximately 2. 5-fold in the gastrocnemius/plantaris. Gastrocnemius glycogen content was twofold higher in AICAR-treated rats than in controls. Chronic chemical activation of AMPK, therefore, results in increases in GLUT-4 protein, hexokinase activity, and glycogen, similarly to those induced by endurance training. (+info)
The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on fatty acid oxidation in hepatocytes isolated from...
PGC-1α is required for AICAR induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle
Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-beta...
AMP-Activated Protein Kinase Activation by AICAR Increases Both Muscle Fatty Acid and Glucose Uptake in White Muscle of Insulin...
4-Amino-5-imidazolecarboxamide hydrochloride (CAS 72-40-2) Market Research Report 2018
LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR
AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages |...
AICAR (5-aminoimidazole-4-carboxamide riboside) - AnabolicMinds.com
Effects of an AICAR treatment on the differentiation of | Open-i
AICAR phosphate (Acadesine phosphate) | AMPK Activator | MedChemExpress
IJMS | Free Full-Text | Ultraviolet (UV) and Hydrogen Peroxide Activate Ceramide-ER Stress-AMPK Signaling Axis to Promote...
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AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2 | Molecular Cancer Research
AICAR & Liraglutide - Exercise & Weight Loss From The Syringe. 50% Body Fat Reduction in 8 Weeks! Is the Pharmacological...
AICAR - ILQO PHARMA
5-Amino-4-imidazolecarboxamide hydrochloride | Phion
1-O-acetyl 2, 3, 5-tri-O-benzoyl-β-D-[UL-13C5] ribofuranoside - Creative Proteomics
Abstract 19979: Rapid ERα-AMPK Signaling Stimulates Vasorelaxation via ERK-Mediated Pathway | Circulation
Top 3 Best AMPK Activator in 2021
Effects of siRNA-AdipoR1 transfection or AICAR treatmen | Open-i
Aicar [Archive] - RX Muscle Forums
N-(2-Ethyl-6-methylphenyl)-2,3-dimethyl-4H-thieno[3,2-c]thiopyran-6-carboxamide | C19H21NOS2 | ChemSpider
TRC | Details of CAS = 138689-15-3, ChemicalName = (5α,17β)-N-Methoxy-N-methyl-3-oxo-4-azaandrost-1-ene-17-carboxamide, synonym...
2r)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide (CAS No. 98717-16-9) Suppliers @ ChemicalRegister.com
Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis<...
The 5 adenosine monophosphate-activated protein kinase: Regulating th by Leonidas G. Karagounis and John Alan Hawley
Inhibition of AMP-activated protein kinase at the allosteric drug-binding site promotes islet insulin release<...
Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in...
5-aminoimidazole ribose 5-phosphate | definition of 5-aminoimidazole ribose 5-phosphate by Medical dictionary
A possible role for AMP-activated protein kinase in exercise-induced glucose utilization: insights from humans and transgenic...
AMP-activated protein kinase and hepatic genes involved in glucose metabolism | Biochemical Society Transactions
Regulation of adenosine 5,monophosphate-activated protein kinase and lipogenesis by androgens contributes to visceral obesity...
AICA-Riboside - CAS 2627-69-2 - Calbiochem CAS 2627-69-2 | 123040
A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner - Lunds universitet
Amino-4-Imidazolecarboxamide Ribotide Directly Inhibits Coenzyme A Biosynthesis in Salmonella enterica | Journal of Bacteriology
An Aspirin a Day? | Science Signaling
Regular exercise can protect the heart against external stimuli, but the | FGFR signaling promotes the growth of triple negative
9 Pillars Archives - National Health and Wellness Club
Structural Insight into AMPK Regulation: ADP Comes into Play<...
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
Expression of AMP-activated Protein Kinase (AMPK) Protein in Lung Adenocarcinoma - Full Text View - ClinicalTrials.gov
A 769662 | AMP-activated protein kinase (AMPK) activator | Hello Bio
AMPK and metabolic adaptation of muscle to exercise, Aicar effects | superhumangear
MOTS-c (human) |AMPK activator | Hello Bio
Research programme: AMP-activated protein kinase stimulants - Connexios/Boehringer Ingelheim - AdisInsight
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AMPK alpha 1 + AMPK alpha 2抗体[34.2]|Anti-AMPK alpha 1 + AMPK alpha 2抗体[34.2]
AMP-activated Protein Kinase (AMPK) Signaling (Homo sapiens) - WikiPathways
Tieno[2,3-B]pyridíndiónové aktivátory AMPK a ich terapeutické použitie - 28.12.2010 - E 15669 - Databáza patentov Slovenska
Bupivacaine impurity B (2RS)-N-(2,6-dimethylphenyl)piperidine-2-carboxamide- CAS Number 65797-42-4
6-METHOXYQUINOLINE-3-CARBOXAMIDE 71083-30-2 MSDS, Safety Technical Specifications MSDS
6-(2-hydroxyethylamino)pyridazine-3-carboxamide 75680-97-6 H-NMR | C-NMR Spectral Analysis NMR Spectrum
SMART: AMPKBI domain annotation
USP7-USP47 inhibitor | USP7 inhibitor | USP7/47 inhibitor compound 14 | CAS [1247825-37-1] | Axon 2991 | Axon Ligand™ with |98%...
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IUCr) Acta Crystallographica Section D Volume 67, Part 5, May 2011
AMPK alpha 2抗体|Abcam中国|Anti-AMPK alpha 2抗体
Gentaur Molecular :QED \ AMPK alpha 2 \ 13010
Legere Pharmaceuticals: June 2017
N-(2,6-DICHLOROPYRIDIN-3-YL)-1H-IMIDAZOLE-5-CARBOXAMIDE - Alfa Chemistry
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ampk indicaciones y contraindicaciones | eXiire
Tina Beck, DDS
AICA ribonucleotide
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is ... 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? ... 5-Aminoimidazole-4-carboxamide-1- β - d -ribofuranoside Increases Myocardial Glucose Uptake during Reperfusion and Induces Late ... 2006)doi:10.1152/ajpheart.00906.2005 Longnus SL, Wambolt RB, Parsons HL, Brownsey RW, Allard MF 5-Aminoimidazole-4-carboxamide ...
Acadesine
August 2007). "5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake ... Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP- ... Cronstein BN, Kamen BA (December 2007). "5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting ... Corton JM, Gillespie JG, Hawley SA, Hardie DG (April 1995). "5-aminoimidazole-4-carboxamide ribonucleoside. A specific method ...
Phosphoribosylaminoimidazolecarboxamide formyltransferase
The systematic name of this enzyme class is 10-formyltetrahydrofolate:5-phosphoribosyl-5-amino-4-imidazole-carb oxamide N- ... aminoimidazolecarboxamide ribonucleotide transformylase, and. *transformylase,. *bifunctional purine biosynthesis protein PURH, ...
Inosine monophosphate synthase
Rayl EA, Moroson BA, Beardsley GP (Mar 1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide ... It has two functions: EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase EC 3.5.4.10 - IMP ... Vergis JM, Bulock KG, Fleming KG, Beardsley GP (2001). "Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/ ... "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase". Rasmussen HH, van Damme ...
4-Amino-5-hydroxymethyl-2-methylpyrimidine
Bazurto JV, Heitman NJ, Downs DM (September 2015). Metcalf WW (ed.). "Aminoimidazole Carboxamide Ribotide Exerts Opposing ... In bacteria, HMP-P arises by conversion of the purine biosynthetic precursor 5-aminoimidazole ribotide (AIR) through the action ...
Temozolomide
... and 5-aminoimidazole-4-carboxamide (AIC). Other metabolites include temozolomide acid and unidentified hydrophilic substances. ... imidazole-4-carboxamide (MTIC). MTIC splits into monomethylhydrazine, probably the active methylating agent, ...
Reduced folate carrier family
... reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide ...
Chemotherapy
It primarily inhibits the enzyme thymidylate synthase, but also has effects on DHFR, aminoimidazole carboxamide ribonucleotide ...
Adenylosuccinate lyase
... to 5-aminoimidazole-4-carboxamide ribotide (AICAR) and fumarate. AICAR proceeds through three more reactions before it becomes ... In the first reaction, ASL converts 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR) ...
Biosynthesis
... forming N-succinyl-5-aminoimidazole-4-carboxamide ribonucleotide (SAICAR). SAICAR lyase removes the carbon skeleton of the ... leaving the amino group and forming 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). AICAR transformylase transfers a ... Firestine, SM; Poon, SW; Mueller, EJ; Stubbe, J; Davisson, VJ (Oct 4, 1994). "Reactions catalyzed by 5-aminoimidazole ... forming the 5-membered imidazole ring 5-aminoimidazole ribonucleotide (AIR). N5-CAIR synthetase transfers a carboxyl group, ...
Ribonucleotide
... the removal of the carbon skeleton of aspartate by SAICAR lyase results in 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR ... as 5-aminoimidazole ribonucleotide (AIR). A carboxyl group is attached to AIR by N5-CAIR synthetase to form N5- ... along with amino group from aspartate forms an amide bond to create N-succinyl-5-aminoimidazale-4-carboxamide ribonucleotide ( ... forming N-formylaminoimidazole-4-carboxamide ribonucleotide (FAICAR). Lastly, closure of the second ring structure is carried ...
Ribavirin
... and replacement with an amino group results in the natural purine synthetic precursor 5-aminoimidazole-4-carboxamide-1-β-D- ... The most successful ribavirin derivative to date is the 3-carboxamidine derivative of the parent 3-carboxamide, first reported ... 4-triazole-3-carboxamide". Science. 177 (4050): 705-6. Bibcode:1972Sci...177..705S. doi:10.1126/science.177.4050.705. PMID ...
List of MeSH codes (D03)
... aminoimidazole carboxamide MeSH D03.383.129.308.040 - antazoline MeSH D03.383.129.308.080 - biotin MeSH D03.383.129.308.090 - ...
MT-RNR1
... purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide ...
Proline oxidase
Activation of AMP-activated protein kinase (AMPK), the cellular energy sensor, by 5-aminoimidazole-4-carboxamide ribonucleoside ...
TIM barrel
5-aminoimidazole-4-carboxamide ribonucleotide (ProFAR) to N-[(5-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide ...
Adenylosuccinate lyase deficiency
... both of which involve the β-elimination of fumarate to produce aminoimidazole carboxamide ribotide (AICAR) from SAICAR or ...
Chemotherapy
It primarily inhibits the enzyme thymidylate synthase, but also has effects on DHFR, aminoimidazole carboxamide ribonucleotide ...
5-Aminoimidazole 4-Carboxamide Ribonucleotide Formyltransferase ELISA Kits | Biocompare.com
Compare 5-Aminoimidazole 4-Carboxamide Ribonucleotide Formyltransferase ELISA Kits from leading suppliers on Biocompare. View ... 5-Aminoimidazole 4-Carboxamide Ribonucleotide Formyltransferase ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a ... Your search returned 13 5-Aminoimidazole 4-Carboxamide Ribonucleotide Formyltransferase ELISA ELISA Kit across 5 suppliers. ...
AICAR (5-aminoimidazole-4-carboxamide riboside) - AnabolicMinds.com
Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5...
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1...
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) is an activator of AMP activated protein kinase (AMPK) and a ... Cell cycle regulation via p53 phosphorylation by a 5-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1 ... Aminoimidazole Carboxamide/analogs & derivatives*. *Aminoimidazole Carboxamide/pharmacology*. *Carcinoma, Hepatocellular/ ...
ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase)
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase), Authors: Jean-Loup Huret. Published in: ... ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). Written. 2001-08. Jean-Loup Huret. ... ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). Atlas Genet Cytogenet Oncol Haematol ... Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase.. Sugita T, Aya H, ...
Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside | Molecular...
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? ... Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside inhibits cancer cell proliferation in ... Because of its ability to mimic a low energy status of the cell, the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide ( ... Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside. Annelies ...
5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men |...
ZMP, 5-aminoimidazole-4-carboxamide ribonucleoside. Skeletal muscle is the major site of whole-body glucose disposal during ... Bergeron R, Previs SF, Cline GW, Perret P, Russell RR 3rd, Young LH, Shulman GI: Effect of 5-aminoimidazole-4-carboxamide-1-β-d ... 5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men. ... 5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men ...
Buy Online TRC - 5-Aminoimidazole-4-carboxamide-15N2 Hydrochloride (>90%) | LGC...
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate...
Aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase), one of the two folate-dependent enzymes in the de ... Aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase), one of the two folate-dependent enzymes in the de ... Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate ...
Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and...
Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and ... Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and ... Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and ... Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and ...
Inhibitory Effect of Aminoimidazole Carboxamide Ribonucleotide (AICAR) on Endotoxin-Induced Uveitis in Rats | IOVS | ARVO...
Nath N Giri S Prasad R Salem ML Singh AK Singh I . 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with ... Giri S Nath N Smith B Viollet B Singh AK Singh I . 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits ... Inhibitory Effect of Aminoimidazole Carboxamide Ribonucleotide (AICAR) on Endotoxin-Induced Uveitis in Rats ... Inhibitory Effect of Aminoimidazole Carboxamide Ribonucleotide (AICAR) on Endotoxin-Induced Uveitis in Rats ...
Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and...
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP is widely used as an activator of AMP-kinase ( ... Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and ... Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and ... Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and ...
Metabolomics Identifies Pyrimidine Starvation as the Mechanism of 5-Aminoimidazole-4-Carboxamide-1-β-Riboside-Induced Apoptosis...
Aminoimidazole carboxamide ribonucleoside toxicity: a model for study of pyrimidine starvation. J Cell Physiol 1981;107:335-44. ... AICAr (5-aminoimidazole-4-carboxamide-1-β-riboside) is a nucleoside that is taken up by cells by adenosine transporters and ... 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP- ... 5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved ...
Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-beta...
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR, an activator of AMP-activated protein kinase), can also induce ... 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR, an activator of AMP-activated protein kinase), can also induce ... Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-beta- ... Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-beta- ...
Augmentation of Reduced Folate Carrier-Mediated Folate/Antifolate Transport through an Antiport Mechanism with 5-Aminoimidazole...
5-aminoimidazole-4-carboxamide riboside. MTX. methotrexate. ZMP. 5-aminoimidazole-4-carboxamide ribotide monophosphate. 5- ... 5-aminoimidazole-4-carboxamide ribotide diphosphate. ZTP. 5-aminoimidazole-4-carboxamide ribotide triphosphate. mTOR. mammalian ... 2005) 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP- ... 1981) Aminoimidazole carboxamide ribonucleoside toxicity: a model for study of pyrimidine starvation. J Cell Physiol 107:335- ...
Effect of Topical 5-Aminoimidazole-4-carboxamide-1-β-d-Ribofuranoside in a Mouse Model of Experimental Dry Eye | IOVS | ARVO...
Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats. Invest Ophthalmol ... Purpose.: To investigate the efficacy of topical 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) in a mouse model ... Giri S, Nath N, Smith B, Viollet B, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits ... Nath N, Giri S, Prasad R, Salem ML, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator ...
Aminoimidazole Carboxamide | Profiles RNS
"Aminoimidazole Carboxamide" by people in this website by year, and whether "Aminoimidazole Carboxamide" was a major or minor ... "Aminoimidazole Carboxamide" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Nath N, Giri S, Prasad R, Salem ML, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator ... Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation ...
5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts |...
Our previous studies demonstrated that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAr) induced differentiation of ... 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts. * ... Dembitz, V., Lalic, H., Kodvanj, I. et al. 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of ... Lalic H, Dembitz V, Lukinovic-Skudar V, Banfic H, Visnjic D. 5-Aminoimidazole-4-carboxamide ribonucleoside induces ...
RCSB PDB - AMZ Ligand Summary Page
Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis<...
Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis. Jun Suzuki, Takeru Yoshimura, Marina ... Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis. Investigative Ophthalmology and Visual ... Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis. / Suzuki, Jun; Yoshimura, Takeru; ... title = "Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis",. abstract = "PURPOSE. To ...
Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL)...
AICAR, 5-Aminoimidazole-4-Carboxamide-1-β-4-Ribofuranoside; AK, adenosine kinase; AMPK, AMP activated protein kinase; PI3K, ... Rattan R, Giri S, Singh AK, Singh I: 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation ... Corton JM, Gillespie JG, Hawley SA, Hardie DG: 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating ... Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL ...
Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside...
T1 - Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside ... Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside ... Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside ... Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside ...
siRNA targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) - Patent application
0030]In various embodiments, siRNAs that target 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP ... Patent application title: siRNA targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ( ... Patent application title: siRNA targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ( ...
AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) ameliorates hyperglycemia and hyperinsulinemia in type 2 diabetic mice
Role of Serotonergic Agents in Primary Chronic Constipation
"Requirement for Rhizobial Production of 5-Aminoimidazole-4-Carboxamide" by Mary Jo Rosovitz, Jeffrey D. Newman et al.
... and by examining several mutants defective in various pathways of 5-aminoimidazole-4-carboxamide ribonucleolide (AICAR) ... Exogenous application of the purine precursor 5-aminoimidazole-4-carboxamide (AICA) riboside restores infection and enhances ... Exogenous application of the purine precursor 5-aminoimidazole-4-carboxamide (AICA) riboside restores infection and enhances ... Requirement for Rhizobial Production of 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) for Infection of Bean ...
Reactome | 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5...
On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver ... phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and 10-formyltetrahydrofolate to form 5-phosphoribosyl-5- ... 5-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate =, 5-phosphoribosyl-5-formaminoimidazole- ... 5-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5-phosphoribosyl-5-formaminoimidazole- ...
Sex Differences and Role of Estradiol in Hypoglycemia-Associated Counter-Regulation | SpringerLink
5-Aminoimidazole-4-carboxamide-riboside. AMPK. Adenosine 5′-monophosphate-activated protein kinase ... 1H-indole-2-carboxamide). The Journal of Pharmacology and Experimental Therapeutics, 321, 45-50.CrossRefPubMedGoogle Scholar ... Caudal fourth ventricular administration of the AMPK activator 5-aminoimiazole-4-carboxamide-riboside regulates glucose and ...
AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin |...
... we aimed to evaluate the therapeutic potential of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an activator of AMP- ... In this study, we aimed to evaluate the therapeutic potential of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an ... The adenosine monophosphate analogue 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) activates AMP-dependent protein ...
AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages |...
... which occurred independently of its conversion to AMPK-activating 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl ... 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) is an established pharmacological activator of AMP-activated ... 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) was one of the first pharmacological AMPK activators12. Once it is ... Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 53, 4158- ...
AICAR40
- We show in this study that the intracerebroventricular infusion of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), a pharmacological AMP-activated kinase activator, increased insulin-stimulated muscle glycogen synthesis and insulin sensitivity during a hyperinsulinemic clamp. (nih.gov)
- 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) is an activator of AMP activated protein kinase (AMPK) and a regulator of de novo purine synthesis. (nih.gov)
- Activation of AMP-activated protein kinase (AMPK) in rodent muscle by exercise, metformin, 5-aminoimidazole-4-carboxamide 1-β- d -ribofuranoside (AICAR), and adiponectin increases glucose uptake. (diabetesjournals.org)
- AMPK may be pharmacologically activated by AICAR, which undergoes intracellular metabolism to 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP), which mimics the AMP effects on AMPK signaling ( 12 ). (diabetesjournals.org)
- Aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase), one of the two folate-dependent enzymes in the de novo purine biosynthesis pathway, is a promising target for anti-neoplastic chemotherapy. (nih.gov)
- Activation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide-1-β- d -ribofuranoside (AICAR) increases glucose transport in skeletal muscle via an insulin-independent pathway. (diabetesjournals.org)
- Recent evidence indicates that pharmacological activation of AMP-activated protein kinase (AMPK) by 5-aminoimidazole-4-carboxamide-1-β- d -ribofuranoside (AICAR) stimulates glucose transport activity in skeletal muscle ( 11 12 13 ) and heart ( 14 ) in the absence of phosphoinositide 3-kinase activation, suggesting that this action is independent of the insulin-signaling pathway. (diabetesjournals.org)
- To investigate the anti-inflammatory effect of aminoimidazole carboxamide ribonucleotide (AICAR), an analog of adenosine monophosphate (AMP), in endotoxin-induced uveitis (EIU). (arvojournals.org)
- 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. (harvard.edu)
- To investigate the mechanism by which 5-aminoimidazole-4-carboxamide-1-β-riboside (AICAr) induces apoptosis in multiple myeloma cells, we conducted an unbiased metabolomics screen. (aacrjournals.org)
- 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR, an activator of AMP-activated protein kinase), can also induce microvascular recruitment, at doses that do not acutely activate glucose transport in rat muscle. (garvan.org.au)
- 5-Aminoimidazole-4-carboxamide riboside (AICAR), an agent with diverse pharmacological properties, augments transport of folates and antifolates. (aspetjournals.org)
- Transport stimulation correlated with the accumulation of 5-aminoimidazole-4-carboxamide ribotide monophosphate (ZMP), the monophosphate derivative of AICAR, within cells as established by liquid chromatography. (aspetjournals.org)
- To investigate the efficacy of topical 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) in a mouse model of experimental dry eye (EDE). (arvojournals.org)
- Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. (healthsciencessc.org)
- Our previous studies demonstrated that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAr) induced differentiation of monocytic cell lines by activating the ATR/Chk1 via pyrimidine depletion. (biomedcentral.com)
- 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate and analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. (rcsb.org)
- The purpose of the present study was to examine the effect of AMPK activation with the administration of AMPK activator 5-aminoimidazole-4- carboxamide-1-β-d-ribofuranoside (AICAR) to rats on skeletal muscle SIRT1 protein expression as well as peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α) and glucose transporter 4 (GLUT4) protein expression and hexokinase activity. (elsevier.com)
- The uniqueness of AICA riboside as an effector was shown by testing varying concentrations of AICA riboside and purines for this effect, and by examining several mutants defective in various pathways of 5-aminoimidazole-4-carboxamide ribonucleolide (AICAR) synthesis. (marquette.edu)
- and Noel, K. Dale, "Requirement for Rhizobial Production of 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) for Infection of Bean" (1995). (marquette.edu)
- The phosphoribosylaminoimidazolecarboxamide formyltransferase activity of cytosolic ATIC (bifunctional purine biosynthesis protein PURH) catalyzes the reaction of 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and 10-formyltetrahydrofolate to form 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) and tetrahydrofolate. (reactome.org)
- In this study, we aimed to evaluate the therapeutic potential of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an activator of AMP-activated protein kinase, for ameliorating high-fat diet (HFD)-induced pathophysiology in mice. (springer.com)
- 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) is an established pharmacological activator of AMP-activated protein kinase (AMPK). (nature.com)
- Here we report a potent suppression of lipopolysaccharide (LPS)-induced inflammatory gene expression by AICAR in primary human macrophages, which occurred independently of its conversion to AMPK-activating 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl monophosphate. (nature.com)
- Once it is taken up by the cell, AICAR undergoes phosphorylation by adenosine kinase to form 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl monophosphate (ZMP). (nature.com)
- Abstract In the present study, the effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on long-chain fatty acid oxidation by hepatocytes isolated from suckled neonatal pig liver (a low ketogenic and lipogenic tissue) was tested. (uwi.edu)
- In order to determine whether AMPK activation reverses lipid-induced mTOR activation, L6 myotubes were exposed to 0.4 mM palmitate to activate mTORC1/2 in the absence or presence of 5′-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR). (calstate.edu)
- ATIC [5-aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase)-inosine monophosphate cyclohydrolase (IMPCH)] is a bifunctional enzyme that catalyzes the penultimate and final steps in the de novo purine biosynthesis pathway and thus is an attractive anticancer target. (scripps.edu)
- Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha(2) activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. (nih.gov)
- 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. (wikipedia.org)
- 2006)doi:10.1152/ajpheart.00906.2005 Longnus SL, Wambolt RB, Parsons HL, Brownsey RW, Allard MF 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms. (wikipedia.org)
- Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. (wikipedia.org)
- Chemical activation of AMPK with the compound 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) leads to increased glucose uptake ( 15 - 19 ) and enhanced insulin sensitivity in muscle ( 20 , 21 ). (diabetesjournals.org)
- A potential role of AMPK in suppression of inflammatory responses has been suggested by studies using the pharmacological activator of AMPK, 5-aminoimidazole-4-carboxamide ribose (AICAR). (jimmunol.org)
- However, AICAR is taken up by cells and converted to AMP analog 5-aminoimidazole-4-carboxamide-1-β- d -ribofuranotide, which mimics the effect of AMP, thus AICAR is a nonspecific activator of AMPK and has the potential to activate other AMP-sensitive enzymes ( 15 ). (jimmunol.org)
- It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to aden. (genecards.org)
- Aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a by-product of histidine biosynthesis. (asm.org)
- Methotrexate polyglutamates are potent inhibitors of the enzyme aminoimidazole carboxamide ribonucleotide (AICAR) transformylase, among others. (thefreedictionary.com)
- 5-Aminoimidazole-4-carboxamide riboside or acadesine (AICAR) induces apoptosis in chronic lymphocytic leukemia (CLL) cells. (biomedsearch.com)
- Aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase (ATIC) is a bifunctional enzyme with folate-dependent AICAR transformylase and IMP cyclohydrolase activities that catalyzes the last two steps of purine biosynthesis. (embl-heidelberg.de)
Riboside6
- Because of its ability to mimic a low energy status of the cell, the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside was proposed as an antineoplastic agent switching off major energy-consuming processes associated with the malignant phenotype (lipid production, DNA synthesis, cell proliferation, cell migration, etc. (aacrjournals.org)
- In a recent attempt to explore the feasibility of targeting the energy sensing system as a strategy in the treatment of cancer, cancer cells were treated with 5-aminoimidazole-4-carboxamide (AICA) riboside, a cell-permeable nucleoside ( 1 - 3 ). (aacrjournals.org)
- Exogenous application of the purine precursor 5-aminoimidazole-4-carboxamide (AICA) riboside restores infection and enhances the development of bean ( Phas-eolus vulgaris ) root nodules elicited by Rhizobium etli purine auxotrophs. (marquette.edu)
- A 5-aminoimidazole-4-carboxamide (AICA) riboside, a purine nucleoside analog, and a nucleotide biosynthesis precursor with B cell pro-apoptotic activity. (cancer.gov)
- 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting agent for therapy of patients with acute lymphoblastic leukemia: are we there and are there pitfalls? (wikipedia.org)
- Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an AMP analogue, mimicking a low energy status of the cell. (aacrjournals.org)
Ribonucleoside3
- Bai A, Yong M, Ma AG, Ma Y, Weiss CR, Guan Q, Bernstein CN, Peng Z. Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis. (healthsciencessc.org)
- Nath N, Giri S, Prasad R, Salem ML, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis. (healthsciencessc.org)
- 5-aminoimidazole-4-carboxamide ribonucleoside. (wikipedia.org)
Imidazole-4-carboxamide3
- D-ribofuranosyl)imidazole-4-carboxamide and 5-amino-1-(.beta. (wikipedia.org)
- 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide. (uniprot.org)
- Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. (genecards.org)
Ribotide isomerase1
- HisA is a phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ( EC:5.3.1.16 ), involved in the fourth step of histidine biosynthesis. (ebi.ac.uk)
Ribonucleotide formyltransferase2
- Your search returned 13 5-Aminoimidazole 4-Carboxamide Ribonucleotide Formyltransferase ELISA ELISA Kit across 5 suppliers. (biocompare.com)
- Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase. (embl-heidelberg.de)
Transformylase2
- Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. (embl-heidelberg.de)
- The bifunctional enzyme aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) is responsible for catalysis of the last two steps in the de novo purine pathway. (embl-heidelberg.de)
Adenosine1
- Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis. (nih.gov)
ATIC1
- ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide. (wikibooks.org)
Protein5
- Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranosi. (nih.gov)
- Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. (healthsciencessc.org)
- 5-Aminoimidazole-4-carboxamide-1- β - d -ribofuranoside Increases Myocardial Glucose Uptake during Reperfusion and Induces Late Pre-conditioning : Potential Role of AMP-Activated Protein Kinase. (wikipedia.org)
- Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart. (wikipedia.org)
- The yeast His7 protein is a bifunctional protein which catalyzes an amido-transferase reaction that generates imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide. (ebi.ac.uk)
SAICAR1
- SAICAR is converted from 5-aminoimidazole-4-carboxyribonucleotide (CAIR) via phosphoribosylaminoimidazolesuccinocarboxamide synthetase (EC: 6.3.2.6) or SAICAR synthase. (hmdb.ca)
Folate1
- Another feature glycinamide ribonucleotide and 5-amino-4-imidazole of intracellular folate metabolism is the compart- carboxamide ribonucleotide), pyrimidine nucleotide mentation of folate coenzymes between the cytosol biosynthesis (methylation of deoxyuridylic acid to thy- and the mitochondria. (yudu.com)
Synthetase1
- Significantly increased recovery of activity of key pathway enzymes (particularly of labile aminoimidazole ribonucleotide synthetase) coupled with improved assay methods and the use of Percoll in addition to sucrose for gradient centrifugation have together contributed to much higher reaction rates and more definitive analyses of particulate fractions. (plantphysiol.org)
Moieties1
- Larvicidal and fungicidal activity of compounds with hydrazine carboxamide and diazenecarboxamide moieties. (thefreedictionary.com)
Thesaurus1
- Aminoimidazole Carboxamide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (healthsciencessc.org)
Experimental2
- Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis. (healthsciencessc.org)
- 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. (healthsciencessc.org)
Investigate1
- To investigate the Pharmacokinetics of L19IL2, dacarbazine and 5-aminoimidazole -4 carboxamide (AIC). (clinicaltrials.gov)
Generation1
- Environmental Protection Agency and Canadian Pest Management Regulatory Agency registration process for bixafen, a new pyrazole carboxamide fungicide that belongs to a new generation of succinate dehydrogenase inhibitors (SDHI). (thefreedictionary.com)
Ribonucleotide3
- br>Tthe cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of a bifunctional purine-biosynthesis enzyme from E. coli which possesses aminoimidazole-4-carboxamide ribonucleotide transformylase. (iaea.org)
- 5-Aminoimidazole-4-carboxamide ribonucleotide or AICAR 50MG / AICAR POWDER is an analogue of adenosine monophosphate. (kihorsemed.com)
- Aica-Ribonucleotide, or AICAR (aminoimidazole carboxamide ribonucleotide), acts as a protein kinase agent activated by AMP. (sarmsupplements.co.uk)